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Rachel E Roditi, Jennifer J Shin
PURPOSE OF REVIEW: To examine the relationship between otitis media, allergic rhinitis, and age. RECENT FINDINGS: Otitis media and allergic rhinitis are prevalent conditions with a controversial relationship. Some data suggest that these entities are significantly associated, either through allergic rhinitis inducing Eustachian tube dysfunction or through allergic pathophysiology simultaneously occurring intranasally and in the ear. Other studies, however, have refuted this relationship...
October 20, 2018: Current Allergy and Asthma Reports
Adity Bose, Priti Sengupta, Uttam Pal, Sanjib Senapati, Mohd Ahsan, Santanu Roy, Upasana Das, Kamalika Sen
Cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. Here we have studied the binding interactions of a small biologically important phenolic molecule, Thymol (Th), with both α and β cyclodextrins (CDs), which are well known drug delivery vehicles. Extent of encapsulation has been determined using several spectroscopic techniques. In fluorescence experiments, significant increase in fluorescence intensities have been discerned for both the CDs but there had been a much early saturation for αCD...
October 12, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Van Du Nguyen, Hyun-Ki Min, Chang-Sei Kim, Jiwon Han, Jong-Oh Park, Eunpyo Choi
An effective nanoparticle-based drug delivery platform holds great promise for non-invasive cancer therapy. This study explores the breast tumor regression in vivo by synergistic photothermal-chemotherapy based on liposomal nanocomplex (folic acid-gold nanorods-anticancer drug-liposome). The proposed liposomal nanocomplex can enhance the tumor targeting by functionalizing folic acid (FA) molecules on the surface of liposome that encapsulates both gold nanorods (AuNRs) and the doxorubicin (DOX) to combine the photothermal therapy and the chemotherapy, respectively...
October 9, 2018: Colloids and Surfaces. B, Biointerfaces
Lungile Nomcebo Thwala, Diego Pan Delgado, Kevin Leone, Ilaria Marigo, Federico Bennetti, Miguel Chenlo, Clara V Alvarez, Sulay Tovar, Carlos Dieguez, Noémi Stefania Csaba, Maria Jose Alonso
Peptides represent a promising therapeutic class with the potential to alleviate many severe diseases. A key limitation of these active molecules relies on the difficulties for their efficient oral administration. The objective of this work has been the rational design of polymer nanocapsules (NCs) intended for the oral delivery of peptide drugs. For this purpose, we selected insulin glulisine as a model peptide. The polymer shell of the NCs was made of a single layer of protamine, a cationic polypeptide selected for its cell penetration properties, or a double protamine/polysialic acid (PSA) layer...
October 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Pratibha Chauhan, Akhilesh Kumar Tamrakar, Sunil Mahajan, G B K S Prasad
AIM: The present study was undertaken to develop a Curcumin nanoparticle system with chitosan as a hydrophilic carrier. In addition, the anti-diabetic potential of curcumin loaded chitosan nanoparticles were assessed in comparison to those of free curcumin by examining the anti-hyperglycemic efficacy using in vitro assays. METHODS: Curcumin loaded chitosan nanoparticles were prepared and characterized for particle size by transmission electron microscopy, FT-IR, differential scanning calorimetry and therapeutic effects of curcumin loaded chitosan nanoparticles was evaluated by measuring the level of GLUT-4 present at the plasma membrane in L6myc myotubes followed by western blotting...
October 18, 2018: Life Sciences
V T Anju, Parasuraman Paramanantham, Sb Lal Sruthil, Alok Sharan, Marzouq H Alsaedi, Turki M S Dawoud, Asad Syed, Busi Siddhardha
BACKGROUND: The global threat of antimicrobial resistance especially due to the bacterial biofilms has engaged researchers in the search of new treatment modalities. Antimicrobial photodynamic inactivation (aPDI) is one of the alternative treatment modalities which kills bacteria by generating endogenous ROS. In this work authors evaluated the antibacterial and antibiofilm efficacy of rose Bengal (RB) conjugated to CNT against E. coli. METHODS: The interaction of anionic dye to the CNT was studied using UV-Visible spectroscopy, HR-TEM, FTIR and spectrofluorometry...
October 17, 2018: Photodiagnosis and Photodynamic Therapy
Liat Soudry-Kochavi, Natalya Naraykin, Rosanna Di Paola, Enrico Gugliandolo, Alessio Peritore, Salvatore Cuzzocrea, Ehud Ziv, Taher Nassar, Simon Benita
One of the major disadvantages associated with macromolecules therapy is that most of them can only be administered parenterally. Exenatide, an efficient anti-diabetic drug, incretin mimetic, is currently administered subcutaneously (SC) causing compliance issues. Nanoparticles (NPs) are considered a promising solution for oral delivery of this drug. In order to overcome exenatide's inability to cross the enterocytes and to increase its stability in the gastrointestinal (GI) tract, we encapsulated exenatide into a nano-in-micro delivery system...
October 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Gorka Orive, Edorta Santos-Vizcaino, Jose Luis Pedraz, Rosa Maria Hernandez, Julia E Vela Ramirez, Alireza Dolatshahi-Pirouz, Ali Khademhosseini, Nicholas A Peppas, Dwaine F Emerich
Millions of people worldwide suffer from debilitating, progressive, and often permanent loss of vision without any viable treatment options. The complex physiological barriers of the eye contribute to the difficulty in developing novel therapies by limiting our ability to deliver therapeutics in a sustained and controlled manner; especially when attempting to deliver drugs to the posterior eye or trying to regenerate the diseased retina. Cell-based therapies offer a significant potential advancement in these situations...
October 17, 2018: Progress in Retinal and Eye Research
Koya Obara, Natsuko Tohgi, Kyoumi Shirai, Sumiyuki Mii, Yuko Hamada, Nobuko Arakawa, Ryoichi Aki, Shree Ram Singh, Robert M Hoffman, Yasuyuki Amoh
Our previous studies showed that nestin-expressing hair follicle-associated-pluripotent (HAP) stem cells, which reside in the bulge area of the hair follicle, could restore injured nerve and spinal cord and differentiate into cardiac muscle cells. Here we transplanted mouse green fluorescent protein (GFP)-expressing HAP stem-cell colonies enclosed on polyvinylidene fluoride membranes (PFM) into the severed thoracic spinal cord of nude mice. After seven weeks of implantation, we found the differentiation of HAP stem cells into neurons and glial cells...
October 19, 2018: Stem Cell Reviews
Esther Cazares-Cortes, Maria Nerantzaki, Jérôme Fresnais, Claire Wilhelm, Nébéwia Griffete, Christine Ménager
Herein, original magnetic drug delivery nanomaterials for cancer therapy are developed and compared, with the purpose to show active control over drug release by using an alternative magnetic field (AMF). The rationale is to combine polymers and superparamagnetic nanoparticles to trigger such drug release under AMF. Two magnetic nanosystems are thus presented: magnetic nanogels made of thermosensitive and biocompatible polymers and core-shell nanoparticles with a magnetic core and a molecularly imprinted polymer as shell...
October 18, 2018: Nanomaterials
Junyi Li, Caicai Zhao, Liping Wei, Xiang Li, Fuguo Liu, Min Zhang, Xuebo Liu, Yutang Wang
In the current research, a new cichoric acid (CA) encapsulation system was investigated. The optimal condition for the formation of lactoferrin-cichoric acid nanoparticles (LF-CA NPs) was determined by controlling the solution pH, the thermal treatment conditions, and the concentration of CA. Fluorescence indicated that the electrostatic force and the hydrophobic force were the main forces in the formation of LF-CA NPs. LF-CA NPs prepared under different conditions were spherical in shape with smaller particle sizes and good zeta potential demonstrating good colloidal stability...
October 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Meiyu Gai, Wenhao Li, Johannes Frueh, Gleb B Sukhorukov
Surface mediated drug delivery is important for a large variety of applications, especially in medicine to control cell growth, prevent blood platelet activation on implants or for self-disinfecting devices (e.g. catheters). In industrial applications, controlled release of substances from surfaces is needed in a broad range of applications from anti-corrosion systems to anti-biofouling. Polyelectrolyte multilayers (PEM) based microcontainers (MCs) require several days production time, while MCs composed out of polylactic acid (PLA) are entirely hydrophobic, offering no functionality...
October 10, 2018: Colloids and Surfaces. B, Biointerfaces
B Sundararajan, Anil Kumar Moola, K Vivek, B D Ranjitha Kumari
The present study, emphasis on the encapsulation of Ocimum basilicum L. leaf essential oil by utilizing Polysorbate 80 and its evaluation of antibacterial (MIC), antioxidants and larvicidal activity against C. quinquefasciatus. After the encapsulation, nanoemulsion characterized by using a Zeta potential analyzer and Scanning Electron Microscope (SEM). Nanoemulsion was exhibited significantly more antibacterial activity (MIC) against different enteric bacterial pathogens, Enterococcus faecalis (MTCC-2729), Staphylococcus aureus (MTCC-441), Salmonella paratyphi (MTCC-735), Klebsiella pneumoniae (MTCC-432) and antioxidant ability of the formulated nanoemulsion and essential oil was tested and results of DPPH, Hydroxyl radical scavenging activity, Superoxide scavenging activity and FRAP activities exhibits highest antioxidant activity...
October 16, 2018: Microbial Pathogenesis
Heping Wang, Xuechen Gong, Xia Guo, Chun Liu, Yan-Ying Fan, Jin Zhang, Baolong Niu, Wenfeng Li
In this study, we fabricated a series of novel sodium alginate/ZnO hydrogel beads to optimize the release profile of curcumin (Cur) and to avoid the burst release associated with pure hydrogels, which were used to mitigate the weaknesses of Cur, such as rapid physiological clearance and sensitivity to ultraviolet (UV) light and alkaline solutions. The results show that the composite hydrogel beads exhibit good pH sensitivity and controlled-release capacity, which could prolong the residence time of Cur in the gastrointestinal tract...
October 16, 2018: International Journal of Biological Macromolecules
Kensuke Yotsumoto, Kenta Ishii, Miho Kokubo, Sakiko Yasuoka
Polymeric micelles, which form through the self-assembly of poly(ethylene glycol)-poly(amino acid) block copolymers, are systemic nanocarriers in targeted cancer therapy. These micelles can encapsulate therapeutic compounds, such as lipophilic substances, charged compounds, and metal complexes, that have characteristics of increased solubility, sustained release, and improved tissue distribution. However, few studies have been conducted on the local distribution of polymeric micelles. Thus, we evaluated the skin penetration pattern of hydrophobic drugs in polymeric micelles...
October 16, 2018: International Journal of Pharmaceutics
Manoj Kumar Neog, Mahaboobkhan Rasool
The current study aimed to target the delivery of p-coumaric acid (CA), a dietary polyphenol to the synovial macrophages of AIA rats via mannose incorporated liposomal delivery system (ML) with reference to osteoclastogenesis and bone resorption. In vivo imaging and in vitro drug release study indicated the efficiency of mannosylated liposomes to localize at the site of inflammation and increased sustain drug release respectively. Morphological assessment of isolated synovial macrophages with respect to CD86 (synovial macrophages) and CD51 (pre-/osteoclast) indicated that p-coumaric acid encapsulated mannnosylated liposomes (ML-CA) inhibited the osteoclasts differentiation...
October 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Daniel M Chevrier, Lluís Raich, Carme Rovira, Anindita Das, Zhentao Luo, Qiaofeng Yao, Amares Chatt, Jianping Xie, Rongchao Jin, Jaakko Akola, Peng Zhang
Due to the small size and large surface area of thiolate-protected Au nanoclusters (NCs), the protecting ligands are expected to play a substantial role in modulating the structure and properties, particularly in the solution phase. How-ever, little is known on how thiolate ligands explicitly modulate the structural properties of the NCs at atomic level, alt-hough this information is critical for predicting the performance of AuNCs in application settings including as a catalyst interacting with small molecules and as a sensor interacting with biomolecular systems...
October 19, 2018: Journal of the American Chemical Society
Pravin Vejan, Rosazlin Abdullah, Tumirah Khadiran, Salmah Ismail
Sustainable crop production for a rapidly growing human population is one of the current challenges faced by the agricultural sector. However, many of the chemical agents used in agriculture can be hazardous to humans, non-targeted organism and environment. Plant growth promoting rhizobacteria have demonstrated role in promoting plant growth and health under various stress conditions including disease. Unfortunately, bacteria viability degrades due to temperature and other environmental factors (Bashan et al...
October 19, 2018: Letters in Applied Microbiology
Jiangyan Wang, Lei Liao, Yuzhang Li, Jie Zhao, Feifei Shi, Kai Yan, Allen Pei, Guangxu Chen, Guodong Li, Zhiyi Lu, Yi Cui
Nanostructure-design of a pre-reserved hollow space to accommodate 300% volume change of silicon anodes has created exciting promises for high energy batteries. However, challenges with weak mechanical stability during the calendering process of electrode fabrication and poor volumetric energy density remain to be solved. Here we fabricated a pressure-resistant silicon structure by designing a dense silicon shell coating onto secondary micrometer particles, each consisting of many silicon nanoparticles. The silicon skin layer significantly improves mechanical stability, while the inner porous structure efficiently accommodates the volume expansion...
October 19, 2018: Nano Letters
Yuxiang Chen, M Lisa Phipps, James H Werner, Saumen Chakraborty, Jennifer S Martinez
Metal nanoclusters containing a few to several hundred atoms with sizes ranging from sub-nanometer to ∼2 nm occupy an intermediate size regime that bridges larger plasmonic nanoparticles and smaller metal complexes. With strong quantum confinement, metal nanoclusters exhibit molecule-like properties. This Account focuses on noble metal nanoclusters that are synthesized within a single stranded DNA template. Compared to other ligand protected metal nanoclusters, DNA-templated metal nanoclusters manifest intriguing physical and chemical properties that are heavily influenced by the design of DNA templates...
October 19, 2018: Accounts of Chemical Research
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