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Tian-Yi Ding, Zhi-Gang Zhao, Mao-Fei Ran, Yao-Yue Yang
Designing highly efficient and low-cost catalysts is essential toward realizing the practical application of hydrogen generation by formic acid decomposition (FAD) under ambient conditions. Herein, we report the synthesis of a hybrid material of Pd nanoparticles encapsulated within carbon nanotubes (CNTs) (Pd-CNTs-in). Transmission electron microscopy images show that most Pd nanoparticles (mean diameter 4.2 ± 0.8 nm) are located inside the nanotubes. Temperature-programmed reduction studies of H2 reveal that the average reduction temperature of the Pd(II) species adsorbed on the interior wall of the CNTs is 12 °C lower than those adsorbed on the outer walls of the CNT...
December 4, 2018: Journal of Colloid and Interface Science
Neda Kalhor, Cesar A Moran
Eight cases of primary thymic epithelial neoplasms corresponding to seven thymomas and one thymic carcinoma with sebaceous differentiation are presented. The patients are five men and three women between the ages of 45 and 63years (average: 54years) who presented with non-specific symptomatology related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Grossly, all the tumors were described as round to oval measuring from 3.5 to 6.0cm in greatest diameter...
December 8, 2018: Human Pathology
Haoyu Wang, Renee-Tyler Tan Morales, Xin Cui, Jiongxian Huang, Weiyi Qian, Jie Tong, Weiqiang Chen
Macrophages are a predominant immune cell population that drive inflammatory responses and exhibit transitions in phenotype and function during tissue remodeling in disease and repair. Thus, engineering an immunomodulatory biomaterial has significant implications for resolving inflammation. Here, a biomimetic and photoresponsive hyaluronan (HA) hydrogel nanocomposite with tunable 3D extracellular matrix (ECM) adhesion sites for dynamic macrophage immunomodulation is engineered. Photodegradative alkoxylphenacyl-based polycarbonate (APP) nanocomposites are exploited to permit user-controlled Arg-Gly-Asp (RGD) adhesive peptide release and conjugation to a HA-based ECM for real-time integrin activation of macrophages encapsulated in 3D HA-APP nanocomposite hydrogels...
December 7, 2018: Advanced Healthcare Materials
Gangfeng Ouyang, Guosheng Chen, Siming Huang, Xiaoxue Kou, Songbo Wei, Shuyao Huang, Shuqi Jiang, Jun Shen, Fang Zhu
Herein, we reported an amino acid-boosted biomimetic strategy that enabled to rapidly encapsulate or coencapsulate a broad range of proteins and enzymes into microporous metal-organic frameworks (MOFs) with ultrahigh loading efficiency. It relied on the accelerating prenucleated clusters around proteins, through the form of metallothioneins-like self-assembly. We demonstrated that the encapsulated proteins/enzymes could well maintain their native conformations, and the tightness of structural confinement within porous MOFs endowed the enzymes with excellent bioactivity even in harsh conditions (e...
December 11, 2018: Angewandte Chemie
Ryan Djemili, Lucas Kocher, Stéphanie Durot, Anssi Peuroren, Kari Rissanen, Valérie Heitz
The allosteric control of the receptor property of two flexible covalent cages is reported. These receptors consist of two Zn(II) porphyrins connected by four linkers of two different sizes, each incorporating two 1,2,3-triazolyl ligands. Siver(I) ions act as an effector, responsible for an on/off encapsulation mechanism of neutral guest molecules. Binding silver(I) ions to the triazoles opens the cages and triggers the coordination of pyrazine or the encapsulation of N,N'-dibutyl-1,4,5,8-naphthalene diimide...
December 10, 2018: Chemistry: a European Journal
Roderick Adrian Slavcev
The dawn of nanoparticle-encapsulated genes is a revolutionary move in gene therapy. It promises to specifically and safely transport genetic cargo through biological systems within a non-viral "Trojan horse" system.
2018: Experientia. Supplementum
Denis E Reyna, Evripidis Gavathiotis
Apoptosis, a form of programmed cell death that is important for development and homeostasis, is regulated by the BCL-2 family of proteins. Over twenty BCL-2 family members have been classified in three groups based on structural homology and function. The multidomain antiapoptotic proteins promote survival, whereas the multidomain and the BH3-only proapoptotic members induce cell death. Because the interaction among the BCL-2 family members occurs primarily at the mitochondrial outer membrane, biochemical assays using artificial liposomes have been developed to study the functional relationship between these proteins...
2019: Methods in Molecular Biology
Ning Liao, Baolong Luo, Jing Gao, Xiaojuan Li, Zhixia Zhao, Yan Zhang, Yongqing Ni, Fengwei Tian
OBJECTIVES: Four kinds of oligosaccharides were used as co-encapsulating agents to test the effect of extrusion-based microencapsulation on protection of Lactobacillus fermentum L7 against exposure to simulated gastric and intestinal juices as well as long-term refrigeration storage at 4 °C. RESULTS: The combination of alginate with galacto-oligosaccharides, isomalto-oligosaccharides, fructo-oligosaccharides, and xylo-oligosaccharides, or alginate alone exhibited good properties of the beads...
December 10, 2018: Biotechnology Letters
Hyoryong Lee, Hyunchul Choi, Mikyoung Lee, Sukho Park
Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradability are also being developed. Among them, microrobots that swell and deswell in response to temperature changes caused by external near infrared (NIR) stimuli, focused ultrasound, and an alternating magnetic field, have been receiving a great amount of interest as drug carriers for therapeutic cell delivery...
November 16, 2018: Biomedical Microdevices
Guan Wang, Yingli Fu, Steven M Shea, Shashank Sathyanarayana Hegde, Dara L Kraitchman
OBJECTIVES: Peripheral artery disease (PAD) affects 12-14% of the world population, and many are not eligible for conventional treatment. For these patients, microencapsulated stem cells (SCs) offer a novel means to transplant mismatched therapeutic SCs to prevent graft immunorejection. Using c-arm CT and 19 F-MRI for serial evaluation of dual X-ray/MR-visible SC microcapsules (XMRCaps) in a non-immunosuppressed rabbit PAD model, we explore quantitative evaluation of capsule integrity as a surrogate of transplanted cell fate...
December 10, 2018: Magma
Adina Bianca Boşca, Alina Simona Şovrea, Viorel Miclăuş, Flavia Ruxanda, Carmen Mihaela Mihu, Carmen Stanca Melincovici, Anne Marie Constantin, Bianca Nausica Petrescu, Radu Septimiu Câmpian, Alina Elena Pârvu, Aranka Ilea
Giant cell granulomas in the oral cavity are reactive hyperplastic lesions that arise either peripherally in the mucoperiosteum or centrally in the bone. The peripheral giant cell granuloma (PGCG) is a benign lesion induced by local chronic irritation. It may develop at any age, and tends to be more frequent in females. Central giant cell granuloma (CGCG) is a reactive lesion of unknown etiology. It commonly occurs in children and young adults. It is also predominant in females and frequently located in the anterior part of the mandible...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Ana Maria Roşca, Raluca Ţuţuianu, Irina Domnica Titorencu
In modern society, the healing of chronic wounds is still a major cause of discomfort for the patients and a financial burden for the care system. Current approaches use either organic tissue-engineered skin substitutes or stem cells based therapy. It has been shown that mesenchymal stem cells (MSCs) are able to improve the wound healing process by secreting factors with anti-inflammatory, anti-fibrotic and pro-angiogenic activities either as soluble molecules (growth factors, cytokines) or encapsulated within membrane vesicles (microparticles, exosomes)...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Xiu Han, Yujie Jiang, Shuyi Li, Yu Zhang, Xiaonan Ma, Ziheng Wu, Zhenghong Wu, Xiaole Qi
The fabrication of aptamers on DNA nanostructures through the DNA origami method has shown great potential for in vitro and in vivo tumor targeting delivery. Herein, tetrahedral multivalent DNA (Td) nanocages modified with different numbers of MUC1-aptamers (nApt-Td) were obtained via the self-assembly of nucleic acid backbones containing the aptamer DNA fragment without complicated chemical modification steps. Then, doxorubicin (DOX) was encapsulated in the modified nApt-Td nanocages via non-covalent interactions...
December 11, 2018: Nanoscale
Justin L Madrigal, Shahin Shams, Roberta S Stilhano, Eduardo A Silva
Gene therapy using viral vectors has been licensed for clinical use both in the European Union and the United States. Lentivectors (LV) and adeno-associated vectors (AAV) are two promising and FDA approved gene-therapy viral vectors. Many future applications of these vectors will benefit from targeting specific regions of interest within the body. Therefore, building on the early success of these vectors may depend on finding effective delivery systems to localize therapeutic administration. Degradable alginate hydrogels have been tested as appealing delivery vehicles for the controlled delivery of vector payloads...
December 11, 2018: Biomaterials Science
Yu Sakurai, Tomoya Hada, Akari Kato, Yuta Hagino, Wataru Mizumura, Hideyoshi Harashima
Although metastatic cancer is a major cause of death for cancer patients, no efficacious treatment for metastasis is available. We previously showed that the growth of a primary tumor could be inhibited by the administration of an anti-angiogenic small interfering RNA (siRNA) that is encapsulated in an RGD peptide-modified lipid nanoparticle (RGD-LNP). We herein report on the delivery of siRNA by an RGD-LNP to the vasculature is also effective for treating metastatic tumors. We compared the RGD-LNP with the polyethylene glycol (PEG)ylated LNP (PEG-LNP) in terms of accumulation in a lung-metastasized model...
December 21, 2018: Molecular Therapy Oncolytics
Estela Climent, Mandy Hecht, Heike Witthuhn, Kornelia Gawlitza, Knut Rurack
The synthesis, characterization, and application of mesoporous materials containing boron-dipyrromethene (BODIPY) moieties that allow the sensitive and selective detection of HgII in aqueous environments by fluorescence enhancement is reported. For this purpose, BODIPY dye I containing a thia-aza crown ether receptor as the fluorescent probe for the detection of HgII in aqueous environments is encapsulated into mesoporous materials to avoid self-quenching or aggregation in water. Determination of HgII is accomplished within a few seconds with high selectivity and sensitivity, reaching a limit of detection of 12 ppt...
December 2018: ChemistryOpen
Surajit Ghosh, Xuemin Wang, Jinyan Wang, Phuong-Diem Nguyen, Colleen M Janczak, Craig A Aspinwall
Phospholipid nanoshells, for example, liposomes, provide a versatile enabling platform for the development of nanometer-sized biosensors and molecular delivery systems. Utilization of phospholipid nanoshells is limited by the inherent instability in complex biological environments, where the phospholipid nanoshell may disassemble and degrade, thus releasing the contents and destroying sensor function. Polymer scaffold stabilization (PSS), wherein the phospholipid nanoshells are prepared by partitioning reactive monomers into the lipid bilayer lamella followed by radical polymerization, has emerged to increase phospholipid nanoshell stability...
November 30, 2018: ACS Omega
Monica Argenziano, Chiara Lombardi, Benedetta Ferrara, Francesco Trotta, Fabrizio Caldera, Marco Blangetti, Hinanit Koltai, Yoram Kapulnik, Ronit Yarden, Luca Gigliotti, Umberto Dianzani, Chiara Dianzani, Cristina Prandi, Roberta Cavalli
Strigolactones (SLs) are carotenoid-derived plant hormones that exhibit anti-cancer activities. We previously demonstrated that two SL analogues, MEB55 and ST362, inhibit the growth and survival of various cancer cell lines. However, these compounds have low aqueous solubility and stability at physiological pH. Here, we generated SL-loaded glutathione/pH-responsive nanosponges (GSH/pH-NS) to selectively deliver SLs to prostate cancer cells and enhance their therapeutic efficacy. The SLs were readily incorporated into the GSH/pH-NS...
November 9, 2018: Oncotarget
Anne-Claire Groo, Nada Matougui, Anita Umerska, Patrick Saulnier
Introduction: Resistance to traditional antibiotics is an increasingly serious problem. Antimicrobial peptides (AMPs) have emerged as a new therapeutic class with great potential against infectious diseases, as they are less prone to induce resistance. Nanotechnology-based delivery strategies can improve the efficiency and stability of AMPs, particularly against proteolytic degradation. Lipid nanocapsules (LNCs) are a new generation of biomimetic nanocarriers and were used in this study to deliver peptides...
2018: International Journal of Nanomedicine
Mohamadreza Amin, Mahsa Bagheri, Mercedeh Mansourian, Mahmoud Reza Jaafari, Timo Lm Ten Hagen
Introduction: PEGylated liposomes are widely used and studied as carriers for chemotherapeutics. While pharmacokinetics of the encapsulated drug is drastically altered resulting in favorable circulation time, improved tumor accumulation, and better manageable or reduced side effects, therapeutic efficacy has been disappointing. Major drawbacks are a failure to reach the tumor cell, limited penetration depth, and impaired uptake by tumor cells. Materials and methods: Here, we study the implication of HIV-1 transactivator of transcription (TAT)-derived peptides inserted on PEGylated liposomal doxorubicin (PLD) and followed in vitro and in vivo fate...
2018: International Journal of Nanomedicine
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