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Bronchopulmonary dysplasia AND preterm infant

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https://www.readbyqxmd.com/read/30517142/components-of-the-antepartum-intrapartum-and-postpartum-exposome-impact-on-distinct-short-term-adverse-neonatal-outcomes-of-premature-infants-a-prospective-cohort-study
#1
Unzila Ali Nayeri, Catalin S Buhimschi, Guomao Zhao, Irina A Buhimschi, Vineet Bhandari
We aimed to test the hypothesis that determinants of the perinatal clinical exposome related to the underlying etiology of premature birth (PTB) impact differently on select neonatal outcomes. We conducted a prospective longitudinal study of 377 singleton preterm neonates [gestational age (GA) at birth: 23-34 weeks] separated into three distinct contemporaneous newborn cohorts: i) spontaneous PTB in the setting of intra-amniotic infection/inflammation (yes-IAI, n = 116); ii) spontaneous PTB in the absence of IAI (no-IAI, n = 130), and iii) iatrogenic PTB for preeclampsia (iPTB-PE, n = 131)...
2018: PloS One
https://www.readbyqxmd.com/read/30513521/nasal-high-flow-therapy-as-primary-respiratory-support-for-preterm-infants-without-the-need-for-rescue-with-nasal-continuous-positive-airway-pressure
#2
Sanja Zivanovic, Alexandra Scrivens, Raffaella Panza, Peter Reynolds, Nicola Laforgia, Kevin N Ives, Charles C Roehr
AIM: To evaluate the effectiveness of nasal high-flow therapy (nHFT) as primary respiratory support for preterm infants with respiratory distress syndrome (RDS) in two tertiary neonatal units. METHODS: A retrospective outcome analysis of initial respiratory support strategies was performed in two tertiary neonatal units in the UK: John Radcliffe Hospital (JRH), Oxford and St Peter's Hospital (SPH), Chertsey. Infants born between 28+0 and 36+6 weeks gestational age (GA) between May 2013 and June 2015 were included...
December 4, 2018: Neonatology
https://www.readbyqxmd.com/read/30513032/cognitive-skills-in-preterm-infants-with-bronchopulmonary-dysplasia-at-1-year-adjusted-and-2-years-chronological-age
#3
Namirembe J Kazibwe, Phani S Veeranki, Karen E Smith
OBJECTIVE: The objective of this study was to evaluate for decline in cognitive scores from 12 to 24 months of age for preterm infants ≤32 weeks gestational age for those with and without bronchopulmonary dysplasia. STUDY DESIGN: In an observational retrospective study, detailed medical data was collected from the electronic medical records of preterm infants born between January 2009 and December 2015 who had cognitive evaluations using Bayley Scales of Infant Development, 3rd ed (BISD-3) at 12 months corrected gestational age and 24 months chronological age...
December 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30511932/the-effect-of-thyroid-functions-on-osteopenia-of-prematurity-in-preterm-infants
#4
Ufuk Çakır, Cuneyt Tayman
Background It is known that thyroid hormones have effects on bone development. In particular, the effect of thyroid hormones on osteopenia of prematurity (OOP) has not been examined in preterm infants. Our study aimed to examine the relationship between OOP and congenital hypothyroidism (CH) in preterm infants. Methods Very low birth weight infants (VLBW, <1500 g) were included in the study. Thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels were measured on postnatal day 5. Serum calcium, phosphorus and alkaline phosphatase (ALP) levels were studied as standard screening parameters for OOP at postnatal week 4...
December 4, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30505940/effects-of-bronchopulmonary-dysplasia-on-swallow-breath-interaction-and-phase-of-respiration-with-swallow-during-non-nutritive-suck
#5
Eric W Reynolds, Debbie Grider, Rhonda Caldwell, Gilson Capilouto, Abhijit Patwardhan, Richard Charnigo
Objectives: The objective of this study is to describe swallow:breath interaction (SwBr) and phase of respiration incident to swallow (POR) during non-nutritive suck in infants with bronchopulmonary dysplasia and determine if speech-language intervention can modify the characteristics of non-nutritive suck in these infants. Methods: Logistic regression models were used to describe SwBr and POR in 16 low-risk preterm (LRP) infants and 43 infants with bronchopulmonary dysplasia...
September 2018: Journal of Nature and Science
https://www.readbyqxmd.com/read/30496424/impact-of-mode-of-conception-on-neonatal-and-neurodevelopmental-outcomes-in-preterm-infants
#6
Lisa Molines, Simon Nusinovici, Marie Moreau, Mathilde Remy, Pascale May-Panloup, Cyril Flamant, Jean-Christophe Roze, Patrick Van Bogaert, Pierre-Emmanuel Bouet, Géraldine Gascoin
STUDY QUESTION: Is assisted conception associated with neonatal morbidity and mortality and with neurodevelopmental impairment at 2 years of corrected age in preterm infants born before 34 weeks of gestational age? SUMMARY ANSWER: Assisted conception is not associated with an increase in neonatal morbidity and mortality and is even significantly associated with a better 2-year neurodevelopmental outcome in preterm infants. WHAT IS KNOWN ALREADY: Assisted conception appears to increase the rate of preterm births, though few studies have analysed outcomes for these preterm infants...
November 29, 2018: Human Reproduction
https://www.readbyqxmd.com/read/30487291/sustained-inflations-and-avoiding-mechanical-ventilation-to-prevent-death-or-bronchopulmonary-dysplasia-a-meta-analysis
#7
REVIEW
Hendrik S Fischer, Georg M Schmölzer, Po-Yin Cheung, Christoph Bührer
Sustained inflations and avoidance of endotracheal mechanical ventilation (eMV) are delivery room interventions aimed at preventing bronchopulmonary dysplasia (BPD). Their effectiveness is the subject of the present meta-analysis.The databases MEDLINE, EMBASE and CENTRAL were searched for randomised controlled trials (RCTs) of preterm infants that compared: 1) sustained inflations with intermittent positive-pressure ventilation; and 2) a non-intubated strategy of respiratory support with one that prescribed eMV at an earlier stage...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30477618/-clinical-features-and-prognosis-of-bronchopulmonary-dysplasia-complicated-by-pulmonary-hypertension-in-preterm-infants
#8
Chen-Hong Wang, Li-Ping Shi, Xiao-Lu Ma, Li-Zhong DU
OBJECTIVE: To study the clinical features and prognosis of bronchopulmonary dysplasia (BPD) complicated by pulmonary hypertension (PH) in preterm infants. METHODS: A retrospective analysis was performed on the clinical data of 191 preterm infants with BPD. RESULTS: In the 191 preterm infants with BPD, 37 (19.4%), all with moderate or severe BPD, developed PH beyond 36 weeks' corrected age. The incidence rates of PH in infants with moderate and severe BPD were 5...
November 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30471715/rhigf-1-rhigfbp-3-in-preterm-infants-a-phase-2-randomized-controlled-trial
#9
David Ley, Boubou Hallberg, Ingrid Hansen-Pupp, Carlo Dani, Luca A Ramenghi, Neil Marlow, Kathryn Beardsall, Faizah Bhatti, David Dunger, Jason D Higginson, Ajit Mahaveer, Olachi J Mezu-Ndubuisi, Peter Reynolds, Carmen Giannantonio, Mirjam van Weissenbruch, Norman Barton, Adina Tocoian, Mohamed Hamdani, Emily Jochim, Alexandra Mangili, Jou-Ku Chung, Mark A Turner, Lois E H Smith, Ann Hellström
OBJECTIVE: To investigate recombinant human insulin-like growth factor 1 complexed with its binding protein (rhIGF-1/rhIGFBP-3) for the prevention of retinopathy of prematurity (ROP) and other complications of prematurity among extremely preterm infants. STUDY DESIGN: This phase 2 trial was conducted from September 2014 to March 2016. Infants born at a gestational age of 230/7  weeks to 276/7  weeks were randomly allocated to rhIGF-1/rhIGFBP-3 (250 µg/kg/ 24 hours, continuous intravenous infusion from <24 hours of birth to postmenstrual age 296/7  weeks) or standard neonatal care, with follow-up to a postmenstrual age of 404/7  weeks...
November 21, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30467342/genetic-variation-in-crhr1-is-associated-with-short-term-respiratory-response-to-corticosteroids-in-preterm-infants-at-risk-for-bronchopulmonary-dysplasia
#10
Tamorah Lewis, William Truog, Mike Norberg, Philip L Ballard, Dara Torgerson
BACKGROUND: Bronchopulmonary dysplasia (BPD) is an orphan disease and advances in prevention and treatment are lacking. The clinical efficacy of systemic corticosteroid therapy to reduce the severity of lung disease and BPD is highly variable. Our objective was to assess whether candidate SNPs in corticosteroid metabolism and response genes are associated with short-term phenotypic response to systemic corticosteroids in infants at high risk for BPD. METHODS: Pharmacogenetic analysis of data from a large randomized controlled trial (TOLSURF) in infants treated with dexamethasone or hydrocortisone using multivariate linear regression...
November 22, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30464331/preventing-bronchopulmonary-dysplasia-new-tools-for-an-old-challenge
#11
REVIEW
María Álvarez-Fuente, Laura Moreno, Jane A Mitchell, Irwin K Reiss, Paloma Lopez, Dolores Elorza, Liesbeth Duijts, Alejandro Avila-Alvarez, Luis Arruza, Manuel Ramírez Orellana, Eugenio Baraldi, Patrizia Zaramella, Santiago Rueda, Álvaro Gimeno-Díaz de Atauri, Hercília Guimarães, Gustavo Rocha, Elisa Proença, Bernard Thébaud, Maria Jesús Del Cerro
Bronchopulmonary dysplasia (BPD) is the most prevalent chronic lung disease in infants and presents as a consequence of preterm birth. Due to the lack of effective preventive and treatment strategies, BPD currently represents a major therapeutic challenge that requires continued research efforts at the basic, translational, and clinical levels. However, not all very low birth weight premature babies develop BPD, which suggests that in addition to known gestational age and intrauterine and extrauterine risk factors, other unknown factors must be involved in this disease's development...
November 21, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30464016/airway-microbiome-in-adult-survivors-of-extremely-preterm-birth-the-epicure-study
#12
Sylvia A D Rofael, Timothy D McHugh, Rachael Troughton, Joanne Beckmann, David Spratt, Neil Marlow, John R Hurst
Bronchopulmonary Dysplasia(BPD) is a major complication of preterm birth that leads to lifelong respiratory morbidity. The EPICure study has investigated the longitudinal health outcomes of infants born extremely preterm (<26 weeks-gestation). Our aim was to characterise the airway microbiome in young adults born extremely preterm (EP), with and without neonatal BPD, in comparison to matched term-born controls.Induced sputum was collected from 92 young adults age 19 years (51 EP and 41 controls). Typical respiratory pathogens were detected using quantitative-PCR...
November 21, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30460724/effects-of-antenatal-azithromycin-for-ureaplasma-spp-on-neonatal-outcomes
#13
Sung-Ha Kim, Jiyoung Chun, Keun-Hyeok Ko, Tae-Jung Sung
BACKGROUND: Ureaplasma spp. in the maternal genitourinary tract has come to the attention for is becoming more evident as a cause of preterm labor, spontaneous abortion, chorioamnionitis and adverse outcomes. However, a few controversies still remain, namely, whether it should be treated aggressively or not. The aim of this study was to evaluate the effects of maternal azithromycin (AZ) treatment for Ureaplasma colonization on neonatal morbidities including bronchopulmonary dysplasia (BPD)...
November 20, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/30459472/gene-expression-signatures-point-to-a-male-sex-specific-lung-mesenchymal-cell-pdgf-receptor-signaling-defect-in-infants-developing-bronchopulmonary-dysplasia
#14
Christina T Fulton, Tracy X Cui, Adam M Goldsmith, Jennifer Bermick, Antonia P Popova
Male sex is a risk factor for development of bronchopulmonary dysplasia (BPD), a common chronic lung disease following preterm birth. We previously found that tracheal aspirate mesenchymal stromal cells (MSCs) from premature infants developing BPD show reduced expression of PDGFRα, which is required for normal lung development. We hypothesized that MSCs from male infants developing BPD exhibit a pathologic gene expression profile deficient in PDGFR and its downstream effectors, thereby favoring delayed lung development...
November 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30459388/early-red-cell-transfusion-is-associated-with-development-of-severe-retinopathy-of-prematurity
#15
Christopher Lust, Zachary Vesoulis, Ronald Jackups, Steve Liao, Rakesh Rao, Amit M Mathur
OBJECTIVE: To evaluate the association between early (within 10 d) pRBC transfusion and the development of severe ROP. STUDY DESIGN AND METHODS: This was a single-center retrospective study. Inclusion criteria were preterm infants born ≤32 weeks gestation or weighing ≤1500 g. Severe ROP was defined as infants requiring retinal laser ablation or bevacizumab injection. Logistic regression was used to identify the association between transfusions and severe ROP...
November 20, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30446300/modulators-of-inflammation-in-bronchopulmonary-dysplasia
#16
REVIEW
Rashmin C Savani
Over 50 years after its first description, Bronchopulmonary Dysplasia (BPD) remains a devastating pulmonary complication in preterm infants with respiratory failure and develops in 30-50% of infants less than 1000-gram birth weight. It is thought to involve ventilator- and oxygen-induced damage to an immature lung that results in an inflammatory response and ends in aberrant lung development with dysregulated angiogenesis and alveolarization. Significant morbidity and mortality are associated with this most common chronic lung disease of childhood...
November 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/30429870/fgf10-and-human-lung-disease-across-the-life-spectrum
#17
REVIEW
Lawrence S Prince
Lung diseases impact patients across the lifespan, from infants in the first minutes of life through the aged population. Congenital abnormalities of lung structure can cause lung disease at birth or make adults more susceptible to chronic disease. Continuous inhalation of atmospheric components also requires the lung to be resilient to cellular injury. Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/30416016/variability-of-tidal-breathing-parameters-in-preterm-infants-and-associations-with-respiratory-morbidity-during-infancy-a-cohort-study
#18
Jakob Usemann, Andrea Suter, Emanuela Zannin, Elena Proietti, Sotirios Fouzas, Sven Schulzke, Philipp Latzin, Urs Frey
OBJECTIVE: To test whether low variability of tidal volume (VT ) and capnographic indices are predictive of subsequent respiratory morbidity in preterm infants. STUDY DESIGN: In a birth cohort of 133 preterm infants, lung function was performed at 44 weeks postmenstrual age. Associations between the coefficient of variation (CV) of VT (CVVT ) and of expired CO2 volume per breath (CVVE,CO2 ) with rehospitalization, wheeze, and inhalation therapy during infancy were assessed using logistic regression...
November 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30416014/effect-of-prophylaxis-for-early-adrenal-insufficiency-using-low-dose-hydrocortisone-in-very-preterm-infants-an-individual-patient-data-meta-analysis
#19
Michele L Shaffer, Olivier Baud, Thierry Lacaze-Masmonteil, Outi M Peltoniemi, Francesco Bonsante, Kristi L Watterberg
OBJECTIVE: To assess the effect of prophylaxis for early adrenal insufficiency using low-dose hydrocortisone on survival without bronchopulmonary dysplasia (BPD) in very preterm infants using an individual patient data meta-analysis. STUDY DESIGN: All existing randomized controlled trials testing the efficacy of the prophylaxis of early adrenal insufficiency using low-dose hydrocortisone on survival without BPD were considered for inclusion when data were available...
November 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30404739/the-impact-of-time-interval-between-extubation-and-reintubation-on-death-or-bronchopulmonary-dysplasia-in-extremely-preterm-infants
#20
Wissam Shalish, Lara Kanbar, Lajos Kovacs, Sanjay Chawla, Martin Keszler, Smita Rao, Bogdan Panaitescu, Alyse Laliberte, Doina Precup, Karen Brown, Robert E Kearney, Guilherme M Sant'Anna
OBJECTIVE: To explore the relation between time to reintubation and death or bronchopulmonary dysplasia (BPD) in extremely preterm infants. STUDY DESIGN: This was a subanalysis from an ongoing multicenter observational study. Infants with birth weight ≤1250 g, requiring mechanical ventilation, and undergoing their first elective extubation were prospectively followed throughout hospitalization. Time to reintubation was defined as the time interval between first elective extubation and reintubation...
November 5, 2018: Journal of Pediatrics
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