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Bronchopulmonary dysplasia AND preterm infant

Ben Peleg, Omer Globus, Maya Granot, Leah Leibovitch, Ram Mazkereth, Irit Eisen, Iris Morag, Orly Stern, Chava Rozen, Ayala Maayan-Metzger, Tzipora Strauss
OBJECTIVE: To evaluate the impact of a quality improvement intervention during the first hour of life ("Golden Hour") on short-term preterm neonatal outcome. STUDY DESIGN: A comprehensive protocol designed for initial stabilization and treatment of preterm infants that included cord blood sampling, use of a dedicated resuscitation room and improved team communication using Crew Resource Management tools. The infants admitted before and after implementation of the protocol were retrospectively compared in a matched case-control design...
October 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
C Casper, I Sarapuk, H Pavlyshyn
INTRODUCTION: Skin-to-skin contact (SSC) is a cornerstone of neurodevelopment and family-oriented care for preterm infants. The purpose of the present study was to investigate the effectiveness of skin-to-skin contact in preterm babies depending on regularity, duration, and the period of the first contact. MATERIALS AND METHODS: This retrospective study involved 26 premature infants with gestational age 24/0-28/6 weeks who were treated in the neonatal intensive care unit and neonatal department...
October 16, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Eduardo Cuestas, Belén Aguilera, Manuel Cerutti, Alina Rizzotti
OBJECTIVE: To determine whether a sustained neonatal systemic inflammatory response was associated with poor postnatal growth among infants born very preterm during the first year of life. STUDY DESIGN: We studied prospectively 192 infants born preterm (birth weight ≤1.5 kg and gestational age ≤31 weeks). Weight, length, and head circumference were measured at birth, term, 4, and 12 months of corrected age. Serial C-reactive protein and procalcitonin were measured at 1, 3, 7, 14, and 28 days of age and averaged for each infant...
October 16, 2018: Journal of Pediatrics
Ronald I Clyman, Melissa Liebowitz, Joseph Kaempf, Omer Erdeve, Ali Bulbul, Stellan Håkansson, Johanna Lindqvist, Aijaz Farooqi, Anup Katheria, Jason Sauberan, Jaideep Singh, Kelly Nelson, Andrea Wickremasinghe, Lawrence Dong, Denise C Hassinger, Susan W Aucott, Madoka Hayashi, Anne Marie Heuchan, William A Carey, Matthew Derrick, Erika Fernandez, Meera Sankar, Tina Leone, Jorge Perez, Arturo Serize
OBJECTIVE: To compare early routine pharmacologic treatment of moderate-to-large patent ductus arteriosus (PDA) at the end of week 1 with a conservative approach that requires prespecified respiratory and hemodynamic criteria before treatment can be given. STUDY DESIGN: A total of 202 neonates of <28 weeks of gestation age (mean, 25.8 ± 1.1 weeks) with moderate-to-large PDA shunts were enrolled between age 6 and 14 days (mean, 8.1 ± 2.2 days) into an exploratory randomized controlled trial...
October 16, 2018: Journal of Pediatrics
Ranniery Acuña-Cordero, Monica P Sossa-Briceño, Carlos E Rodríguez-Martínez
BACKGROUND: There have been few research studies aimed at obtaining a better understanding of the prediction of subsequent respiratory morbidity at follow-up in infants with a previous history of bronchopulmonary dysplasia (BPD) living in low- and middle-income countries (LMIC). The aim of the present study was to identify predictors of hospitalization for acute lower respiratory infections (ALRIs) in a population of infants with a history of BPD living in a LMIC. METHODS: In a prospective cohort study, we determined independent predictors of the number of hospitalizations for ALRIs during the first two years of life in a population of infants with a history of BPD living in Bogota, Colombia...
October 9, 2018: Early Human Development
Peter M Mourani, Erica W Mandell, Maxene Meier, Adel Younoszai, John T Brinton, Brandie D Wagner, Sanne Arjaans, Brenda B Poindexter, Steven H Abman
RATIONALE: Early pulmonary vascular disease (PVD) after preterm birth is associated with a high risk for developing bronchopulmonary dysplasia (BPD), but its relationship with late respiratory outcomes during early childhood remains uncertain. OBJECTIVE: To determine whether PVD at 7 days after preterm birth is associated with late respiratory disease (LRD) during early childhood. METHODS: Prospective study of preterm infants born before 34 weeks postmenstrual age (PMA)...
October 10, 2018: American Journal of Respiratory and Critical Care Medicine
Mohan Pammi, Charitharth Vivek Lal, Brandie D Wagner, Peter M Mourani, Pablo Lohmann, Ruth Ann Luna, Amy Sisson, Binoy Shivanna, Emily B Hollister, Steven H Abman, James Versalovic, Gary J Connett, Vineet Bhandari, Namasivayam Ambalavanan
OBJECTIVES: To summarize evidence regarding microbial dysbiosis of the airway associated with bronchopulmonary dysplasia (BPD) and to explore heterogeneity among studies. STUDY DESIGN: We included studies that evaluated the airway microbiome in preterm infants who developed BPD using culture-independent molecular techniques and reported alpha- and beta-diversity metrics and microbial profiles. RESULTS: The 6 included studies had substantial clinical and methodological heterogeneity...
October 5, 2018: Journal of Pediatrics
Anett Nagy, Anna Mária Beke, Renáta Cserjési, Rózsa Gráf, Magda Kalmár
INTRODUCTION: Owing to the rapid progress of the medical science and technology, the chances of survival of the extremely low birth weight (<1000 g) preterm babies have dramatically improved. Nevertheless, the research findings on their long-term developmental outcome are inconsistent. AIM: Our study has attempted to contribute to the understanding of the developmental mechanisms in the extremely low birth weight preterm infants and to the prediction of the developmental outcomes taking into account of the risk factors of development...
October 2018: Orvosi Hetilap
Mireille Guillot, Martin Offringa, Thierry Lacaze-Masmonteil, Bernard Thébaud
Bronchopulmonary dysplasia (BPD) is the most common complication of extreme prematurity. Currently, there is no specific treatment available. Preclinical studies support cell-therapy as a promising therapy for BPD in preterm infants. A successful translation to a safe and effective clinical intervention depends on multiple factors including the perspective of neonatal health care providers. A 2 hour workshop with 40 Canadian neonatologists was held to enhance the design of a phase II trial of stem cells for babies at risk for BPD, with a focus on the population to target and the outcomes to measure in such a trial...
October 5, 2018: Canadian Journal of Physiology and Pharmacology
Richard B Parad, Abigail B Winston, Leslie A Kalish, Munish Gupta, Ivana Thompson, Yvonne Sheldon, Joann Morey, Linda J Van Marter
OBJECTIVE: To assess heritable contributions to bronchopulmonary dysplasia (BPD) risk in a twin cohort restricted to gestational age at birth <29 weeks. STUDY DESIGN: A total of 250 twin pairs (192 dichorionic, 58 monochorionic) born <29 weeks gestational age with known BPD status were identified. Three statistical methods applicable to twin cohorts (χ2 test, intraclass correlations [ICCs], and ACE modeling [additive genetic or A, common environmental or C, and unique environmental or E components]) were applied...
September 26, 2018: Journal of Pediatrics
Nam Hyo Kim, Young Ah Youn, Su Jin Cho, Jong-Hee Hwang, Ee-Kyung Kim, Ellen Ai-Rhan Kim, Soon Min Lee
The critical need to emphasize preterm infant follow-up after neonatal intensive care unit (NICU) discharge assures early identification of and intervention for neurodevelopmental disability. The aims of this study were to observe the follow-up rates in high-risk follow-up clinics, and analyze factors associated with non-compliance to follow-up among very low birth weight (VLBW) infants. The data was prospectively collected for 3063 VLBW infants between January 2013 and December 2014 from 57 Korean neonatal network (KNN) centers at a corrected age of 18-24 months...
2018: PloS One
Eduardo Villamor-Martinez, Monica Fumagalli, Owais Mohammed Rahim, Sofia Passera, Giacomo Cavallaro, Pieter Degraeuwe, Fabio Mosca, Eduardo Villamor
Although chorioamnionitis (CA) is a well-known risk factor for white matter disease of prematurity, the association with intraventricular hemorrhage (IVH) is controversial and has not been yet systematically reviewed. We performed a systematic review and meta-analysis of studies exploring the association between CA and IVH. A comprehensive literature search was conducted using PubMed/MEDLINE and EMBASE, from their inception to 1 July 2017. Studies were included if they examined preterm infants and reported primary data that could be used to measure the association between exposure to CA and the presence of IVH...
2018: Frontiers in Physiology
Kengo Inagaki, Chad Blackshear, Charlotte V Hobbs
OBJECTIVE: To assess whether symptomatic congenital cytomegalovirus infection (cCMV) is associated with bronchopulmonary dysplasia (BPD) and mortality in very preterm infants (gestational age ≤32 weeks). STUDY DESIGN: We performed a retrospective study using the Kids' Inpatient Database for 2003, 2006, 2009, and 2012. Diagnoses of BPD and symptomatic cCMV were determined using the International Classification of Diseases, Ninth Revision, Clinical Modification codes...
September 27, 2018: Journal of Pediatrics
Xiaonan Mao, Jie Qiu, Li Zhao, Junjie Xu, Jiao Yin, Yang Yang, Mingshun Zhang, Rui Cheng
Introduction: Vitamin D deficiency and inflammation are involved with bronchopulmonary dysplasia (BPD) in preterm neonates; however, the clinical evidence still remains scarce. We hypothesized that vitamin D and inflammatory cytokines may be risk factors for BPD in infants. Methods: Preterm infants born between 28 and 31 weeks' gestation were recruited between January 2016 and 2017. Blood samples were all collected at corresponding time points. Vitamin D was measured using an automatic biochemical analyzer, and inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-10) were measured using ELISA...
2018: Frontiers in Pediatrics
Daniel E Ehrmann, Peter M Mourani, Steven H Abman, Brenda B Poindexter, Lindsey A Morrow, Brandie D Wagner, Michael V Di Maria
OBJECTIVE: To test the hypothesis that specific echocardiographic measurements of right ventricular (RV) mechanics at 36 weeks postmenstrual age (PMA) are associated with the severity of bronchopulmonary dysplasia (BPD). STUDY DESIGN: A subset of 93 preterm infants (born between 27 and 29 weeks of gestation) was selected retrospectively from a prospectively enrolled cohort. BPD was defined using the National Institutes of Health workshop definition, with modifications for oxygen reduction testing and altitude...
September 21, 2018: Journal of Pediatrics
Yu Suzuki, Kenji Horie, Yukari Yada, Yumi Kono, Chikako Hirashima, Rie Usui, Shigeki Matsubara, Akihide Ohkuchi
Our aim was to investigate the association between vaginal Ureaplasma species (spp.) and the subsequent occurrence of chorioamnionitis (CAM), perinatal death, neonatal morbidity, and long-term neurodevelopmental impairments (NDIs) at 3 years of age. We analyzed 55 pregnant women with singleton pregnancy who had preterm premature rupture of the membranes (pPROM) at < 28+0  weeks of gestation, and delivered between 22+0 and 31+6 weeks at our tertiary hospital in 2007-2016. NDIs were defined as either cerebral palsy or developmental delay evaluated at 1...
September 22, 2018: European Journal of Clinical Microbiology & Infectious Diseases
James I Hagadorn, Mihoko V Bennett, Elizabeth A Brownell, Kurlen S E Payton, William E Benitz, Henry C Lee
OBJECTIVE: To test the hypothesis that neonatal intensive care unit (NICU)-specific changes in patent ductus arteriosus (PDA) management are associated with changes in local outcomes in preterm infants. STUDY DESIGN: This retrospective repeated-measures study of aggregated data included infants born 400-1499 g admitted within 2 days of delivery to NICUs participating in the California Perinatal Quality Care Collaborative. The period 2008-2015 was divided into four 2-year epochs...
September 20, 2018: Journal of Pediatrics
Petter Brattström, Chiara Russo, David Ley, Matteo Bruschettini
AIM: Though caffeine is a consolidated treatment in preterm infants, the efficacy and safety of a higher dose have not been systematically appraised. METHODS: A systematic review was conducted to compare high (loading dose >20 mg/kg and maintenance >10 mg/kg/day) versus low dose of caffeine. MEDLINE, EMBASE, Central, and conference proceedings for randomized controlled trials (RCTs) and quasi-RCTs were searched. Two authors independently screened the records, extracted the data and assessed the risk of bias...
September 22, 2018: Acta Paediatrica
Manuel Blesa, Gemma Sullivan, Devasuda Anblagan, Emma J Telford, Alan J Quigley, Sarah A Sparrow, Ahmed Serag, Scott I Semple, Mark E Bastin, James P Boardman
Preterm infants are at increased risk of alterations in brain structure and connectivity, and subsequent neurocognitive impairment. Breast milk may be more advantageous than formula feed for promoting brain development in infants born at term, but uncertainties remain about its effect on preterm brain development and the optimal nutritional regimen for preterm infants. We test the hypothesis that breast milk exposure is associated with improved markers of brain development and connectivity in preterm infants at term equivalent age...
September 18, 2018: NeuroImage
Mesut Dursun, Sinan Uslu, Ali Bulbul, Muhittin Celik, Umut Zubarioglu, Evrim Kiray Bas
Aims: To compare the effect of early nasal intermittent positive pressure ventilation (nIPPV) and nasal continuous positive airway pressure (nCPAP) in terms of the need for endotracheal ventilation in the treatment of respiratory distress syndrome (RDS) in preterm infants born between 24 and 32 gestational weeks. Methods: This is a randomized, controlled, prospective, single-centered study. Forty-two infants were randomized to nIPPV and 42 comparable infants to nCPAP (birth weight 1356 ± 295 and 1359 ± 246 g and gestational age 29...
September 17, 2018: Journal of Tropical Pediatrics
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