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Developmental outcome AND preterm infant

Tanusha Ramdin, Daynia Ballot, David Rakotsoane, Lethile Madzudzo, Nicolette Brown, Tobias Chirwa, Peter Cooper, Victor Davies
BACKGROUND: Late preterm infants, previously considered low risk, have been identified to be at risk of developmental problems in infancy and early childhood. There is limited information on the outcome of these infants in low and middle income countries. METHODS: Bayley scales of infant and toddler development, version III, were done on a group of late preterm infants in Johannesburg, South Africa. The mean composite cognitive, language and motor sub-scales were compared to those obtained from a group of typically developed control infants...
October 15, 2018: BMC Pediatrics
Laurel Gower, Dorothea Jenkins, Jamie L Fraser, Viswanathan Ramakrishnan, Patty Coker-Bolt
OBJECTIVE: To evaluate the Specific Test of Early Infant Motor Performance (STEP), a rapid screening test of preterm infants at risk for developmental delay. STUDY DESIGN: We prospectively studied 23 preterm infants' performance on the STEP and the Test of Infant Motor Performance (TIMP) at term and 3 months, and on the Bayley-III at 12 months. We investigated the psychometric qualities of the STEP and determined STEP cutoff scores for low and high-performing infants...
October 9, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Elaine M Boyle, Ranveer S Sanghera
Until recently, there has been a strongly held belief on the part of neonatal and paediatric clinicians that outcomes for infants born close to term are not different from those of babies born at full term. In the last decade, however, this assumption has been challenged by reports suggesting that this is not correct, and highlighting differences in morbidity and mortality both in the short and long term. This has led to development of new terminology to more accurately reflect the impact of immaturity associated with birth at 32-33 weeks (moderately preterm) and 34-36 weeks (late preterm) of gestation...
October 4, 2018: Minerva Pediatrica
Roberto Palumbi, Antonia Peschechera, Mariella Margari, Francesco Craig, Arcangelo Cristella, Maria Giuseppina Petruzzelli, Lucia Margari
BACKGROUND: Over the last decade, several studies investigated the outcomes in children born very preterm. Only recently there has been an increasing interest in the late preterm infants (born between 34 + 0 and 36 + 6 weeks). This population is at high risk of morbidity and mortality in the first years of life. Other studies reported that they are also at risk of long-term developmental problem. Therefore, the aim of this study is to describe the neurodevelopmental and emotional-behavioral outcome in a sample of late preterm patients...
October 8, 2018: BMC Pediatrics
Anett Nagy, Anna Mária Beke, Renáta Cserjési, Rózsa Gráf, Magda Kalmár
INTRODUCTION: Owing to the rapid progress of the medical science and technology, the chances of survival of the extremely low birth weight (<1000 g) preterm babies have dramatically improved. Nevertheless, the research findings on their long-term developmental outcome are inconsistent. AIM: Our study has attempted to contribute to the understanding of the developmental mechanisms in the extremely low birth weight preterm infants and to the prediction of the developmental outcomes taking into account of the risk factors of development...
October 2018: Orvosi Hetilap
Andrea F Duncan, Carla M Bann, Allison Dempsey, Myriam Peralta-Carcelen, Susan Hintz
OBJECTIVE: To investigate associations in toddlers born extremely preterm (<28 weeks) between neonatal neuroimaging and 18- to 22-month developmental and behavioral outcomes. STUDY DESIGN: Cohort analysis from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Surfactant Positive Airway Pressure and Pulse Oximetry Trial Neuroimaging and Neurodevelopmental Outcomes Study of infants born extremely preterm...
October 3, 2018: Journal of Pediatrics
Umamaheswari Balakrishnan, Prakash Amboiram, Binu Ninan, Anupama Chandrasekharan, Rajeswaran Rangaswamy, Lalitha Subramanian
INTRODUCTION: Preterm infants are at increased risk of adverse neuro-developmental outcome (NDO). Cranial ultrasound has limited predictability. The aim of the study is to evaluate whether MRI done at term equivalent age (TEA) predicts NDO at 18-22 months of corrected gestational age (CGA). METHOD: This cohort study of preterm infants born at ≤ 32 weeks of gestation and/or birth weight < 1500 grams between April 2011 and August 2012, was conducted in a tertiary care institute in India...
October 3, 2018: Journal of Maternal-fetal & Neonatal Medicine
Rachel E Lean, Rachel A Paul, Tara A Smyser, Christopher D Smyser, Cynthia E Rogers
OBJECTIVE: To assess the extent to which social and family factors explain variability in cognitive, language, and motor development among very preterm (<30 weeks of gestation) children from 2 to 5 years of age. STUDY DESIGN: As part of a longitudinal study, very preterm children recruited as neonates were assessed at 2 (n = 87) and 5 (n = 83) years of age using standardized tests of cognitive, language, and motor ability alongside demographically matched full term (FT) children (n = 63)...
September 21, 2018: Journal of Pediatrics
Giuseppina Sgandurra, Elena Beani, Matteo Giampietri, Riccardo Rizzi, Giovanni Cioni
BACKGROUND: Congenital brain lesions expose infants to be at high-risk for being affected by neurodevelopmental disorders such as cerebral palsy (CP). Early interventions programs can significantly impact and improve their neurodevelopment. Recently, in the framework of the European CareToy (CT) Project ( ), a new medical device has been created to deliver an early, intensive, customized, intervention program, carried out at home by parents but remotely managed by expert and trained clinicians...
September 5, 2018: BMC Pediatrics
Danielle deCampo, Misun Hwang
Prematurity is associated with significant neurological injury and impaired neurodevelopment. In neonatology, ultrasonography is frequently used to assess for neurological injury. Ultrasonography allows rapid bedside imaging without radiation. Its limitations include the need for operator experience, lack of quantification, and lower prognostic power when compared with magnetic resonance imaging. Elastography is one of several technical advances used to enhance the diagnostic capability of traditional ultrasound...
July 10, 2018: Pediatric Neurology
Jai K Das, Zahra Hoodbhoy, Rehana A Salam, Afsah Zulfiqar Bhutta, Nancy G Valenzuela-Rubio, Zita Weise Prinzo, Zulfiqar A Bhutta
BACKGROUND: Ready-to-use lipid-based nutrient supplements (LNS) are a highly nutrient-dense supplement, which could be a good source of macro- and micronutrients for pregnant women who need to supplement their nutrient intake. OBJECTIVES: To assess the effects of LNS for maternal, birth and infant outcomes in pregnant women. Secondary objectives were to explore the most appropriate composition, frequency and duration of LNS administration. SEARCH METHODS: In May 2018, we searched CENTRAL, MEDLINE, Embase, 22 other databases and two trials registers for any published and ongoing studies...
August 31, 2018: Cochrane Database of Systematic Reviews
Alice C Burnett, Jeanie L Y Cheong, Lex W Doyle
Although very preterm birth and very low birthweight are recognized risk factors for longer term developmental difficulties, there is a wide spectrum of outcomes for children and adolescents born preterm. Biological and social variables have the potential to explain this variability. Although current understanding of these influences and how they interact is incomplete, perinatal factors are related to permanent neurosensory impairments such as cerebral palsy, blindness, and deafness. Cognitive and academic outcomes are variably associated with biological and social variables across development, and the most robust correlates of behavior and mental health difficulties include early behavioral problems and family influences...
September 2018: Clinics in Perinatology
Sara B DeMauro
The rate of bronchopulmonary dysplasia (BPD) in preterm infants is increasing; this trend reflects, in part, improved survival among extremely premature infants. BPD is associated with adverse developmental and medical outcomes in early childhood and at least through school age. Therefore, BPD imposes a significant burden on infants and children, their families, and society. Many interventions to decrease BPD and the sequelae of BPD have been studied; few to date have been proved to decrease both BPD and later disability...
September 2018: Clinics in Perinatology
Mostafa A Abolfotouh, Saif Al Saif, Waleed A Altwaijri, Mohammed A Al Rowaily
BACKGROUND: Survival of preterm neonates has steadily improved over the past five decades, due to changes in the neonatal intensive care. However, in Saudi Arabia, there are no written guidelines on the definition of the lower limit of viability, and there has been a call for such a limit. The aims of this study were: (1) to determine lower limits of viability and survival in extremely low birthweight (ELBW) infants, and (2) to determine incidence of neurodevelopmental and cognitive abnormalities within 3-6 years after birth...
August 22, 2018: BMC Pediatrics
M J Taylor, M M Vandewouw, J M Young, D Card, J G Sled, M M Shroff, C Raybaud
PURPOSE: Brain metabolites show very rapid maturation over infancy, particularly following very preterm (VPT) birth, and can provide an index of brain injury. The utility of magnetic resonance imaging (MRS, magnetic resonance spectroscopy) in predicting outcome in VPT-born infants is largely limited to 2-year outcomes. We examined the value of MRS in VPT followed longitudinally to 4 years. METHODS: MRS datasets were acquired in 45 VPT infants (< 32 weeks gestational age) longitudinally: at birth, at term-equivalent and at 4 years of age...
October 2018: Neuroradiology
Hassib Chehade, Umberto Simeoni, Jean-Pierre Guignard, Farid Boubred
Cardiovascular and chronic kidney diseases are part of non-communicable chronic diseases, the leading causes of premature death worldwide. They are recognized as having early origins through altered developmental programming, due to adverse environmental conditions during development. Preterm birth is increasingly recognized as such an adverse factor. Rates of preterm birth have increased the last decades, however, with the improvement in perinatal and neonatal care, a growing cohort have survived to the neonatal period and are now entering adulthood...
August 13, 2018: Current Pediatric Reviews
Rita C Silveira, Eliane Wagner Mendes, Rubia Nascimento Fuentefria, Nadia Cristina Valentini, Renato S Procianoy
BACKGROUND: Preterm infants are high risk for delayed neurodevelopment. The main goal is to develop a program of early intervention for very preterm infants that allows families to apply it continuously at home, and quantify the results of early parental stimulation on improvement of cognition and motor skills. METHODS: Randomized clinical Trial including inborn preterm infants with gestational age less than 32 weeks or birth weight less than 1500 g at 48 h after birth...
August 9, 2018: BMC Pediatrics
Ling-Ju Chuang, Shih-Hao Wang, Mi-Chia Ma, Chia-Ni Lin, Chih-Ling Chen, Mei-Chih Huang
AIMS AND OBJECTIVES: To determine the comparative efficacy of developmental care versus standard care for reducing pain and stress in preterm infants during examinations for retinopathy of prematurity (ROP). BACKGROUND: ROP examinations are routinely performed in neonatal intensive care units to detect these lesions. Pain scores recorded during and after eye examinations have revealed physiological and behavioural manifestations of pain and stress. DESIGN: A randomised crossover trial was conducted...
August 9, 2018: Journal of Clinical Nursing
Alan Hall Jobe
Antenatal corticosteroids (ACS) are standard of care for women at risk of preterm delivery between 24 -34 weeks gestation. Their use decreases preterm morbidities and mortality. However, ACS treatments mimic a stress response by increasing fetal steroid levels at early gestational ages when the fetus is normally protected from high glucocorticoid levels. Within the context of concept of the developmental origins of adult health and disease, ACS are effective stressors in fetal animal models that alter developmental programs and outcome in adult animals...
August 8, 2018: Canadian Journal of Physiology and Pharmacology
Sanjeet Panda, Preeti Dohare, Samhita Jain, Nirzar Parikh, Pranav Singla, Rana Mehdizadeh, Damon W Klebe, George M Kleinman, Bokun Cheng, Praveen Ballabh
Development of cortical interneurons continues until the end of human pregnancy. Premature birth deprives the newborns from the supply of maternal estrogen and a secure intrauterine environment. Indeed, preterm infants suffer from neurobehavioral disorders. This can result from both preterm birth and associated postnatal complications, which might disrupt recruitment and maturation of cortical interneurons. We hypothesized that interneuron subtypes, including parvalbumin-positive (PV+ ), somatostatin-positive (SST+ ), calretinin-positive (CalR+ ), and neuropeptide Y-positive (NPY+ ) interneurons, were recruited in the upper and lower cortical layers in a distinct manner with advancing gestational age...
August 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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