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Hanna Knihtilä, Anne Kotaniemi-Syrjänen, Anna S Pelkonen, Mika J Mäkelä, L Pekka Malmberg
BACKGROUND: Clinical significance of small airway obstruction in mild pediatric asthma is unclear. OBJECTIVE: To evaluate small airway properties in children with mild-tomoderate asthmatic symptoms, and the association of small airway function with asthma control and exercise-induced bronchoconstriction (EIB). METHODS: Children (5-10 years) with either recurrent wheezing (n=42) or persistent troublesome cough (n=16), and healthy controls (n=19) performed impulse oscillometry (IOS), spirometry, and multiple-breath nitrogen washout (MBNW) test...
July 27, 2018: Annals of Allergy, Asthma & Immunology
Gerald S Zavorsky, Ralph D Zimmerman, Derek G Shendell, Lynda T Goodfellow
BACKGROUND: Prolonged endurance running may acutely reduce spirometric lung values. This study examined changes in spirometry before and immediately after prolonged endurance exercise (running and/or walking). Specifically, we examined potential factors that predict the presence of at least a 10% postexercise reduction in FEV1 . METHODS: After institutional review board approval, recruitment occurred at a pre-race exposition, where informed consent was obtained...
July 24, 2018: Respiratory Care
Beatriz Gullón, Patricia Gullón, Gemma Eibes, Cristóbal Cara, Antonia De Torres, Juan Carlos López-Linares, Encarnación Ruiz, Eulogio Castro
A large amount of olive-derived biomass is generated yearly in Spain, which could be used as a potential source of bioactive compounds. The present work evaluates the recovery of natural antioxidants from olive tree pruning (OTP) and olive mill leaves (OML). For this purpose, the effect of different solvents on the total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity was evaluated. The solvent was found to have a significant effect (p < 0.05) on the TPC, TFC, and the DPPH, ABTS, and FRAP activity, affording similar results for the extracts from the two by-products...
July 17, 2018: Science of the Total Environment
Maisi Muniz Cabral David, Evelim Leal de Freitas Dantas Gomes, Maryjose Carvalho Mello, Dirceu Costa
BACKGROUND: Asthma is characterized by hyperresponsiveness of the airways, and exercise-induced bronchospasm (EIB) is a symptom that limits a large proportion of asthmatic patients, especially children. Continuous positive airway pressure (CPAP) leads to a reduction in the reactivity of the airways. The aim of this study was to evaluate the effect of outpatient treatment with CPAP and bilevel pressure combined with respiratory physical therapy for children and adolescents with asthma following bronchial hyperresponsiveness caused by an exercise bronchoprovocation test...
January 2018: Therapeutic Advances in Respiratory Disease
Kyubo Kim, Hong Je Cho, Jung Won Yoon, Sun Hee Choi, Youn Ho Sheen, ManYong Han, Heysung Baek
BACKGROUND: Exercise-induced bronchoconstriction (EIB) is diagnosed via exercise challenge on a treadmill. However, such testing requires complex equipment and sufficient healthcare resources. The fraction of exhaled nitric oxide (FeNO) test and mannitol bronchial provocation test (BPT) may serve as a surrogate of exercise testing. METHODS: We compared the diagnostic utilities of the FeNO test and mannitol BPT in predicting EIB in asthmatic children. We retrospectively analysed data from 60 asthmatic children aged 6-16 years...
May 22, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Edil de Albuquerque Rodrigues Filho, José Ângelo Rizzo, Adriana Velozo Gonçalves, Marco Aurélio de Valois Correia Junior, Emanuel Sávio Cavalcanti Sarinho, Décio Medeiros
BACKGROUND: Respiratory complaints after exercise are common in patients with rhinitis. Exercise-induced bronchospasm (EIB) may be one of the causes. OBJECTIVES: To evaluate EIB prevalence in a group of children and adolescents with allergic rhinitis, to compare the treadmill running (TR) and eucapnic voluntary hyperventilation (EVH) challenge methods as diagnostic tools and to assess the association between respiratory complaints on exercise and EIB. METHODS: Patients aged between 10 and 20 years were studied at the Pulmonology Department of the Hospital das Clínicas -UFPE- Recife, Brazil...
May 2018: Respiratory Medicine
Anna R Jackson, James H Hull, James G Hopker, John W Dickinson
Our aim was to evaluate the prevalence of exercise-induced bronchoconstriction (EIB) in elite football players and assess subsequent impact of therapy on airway health and exercise performance. 97 male professional football players completed an airway health assessment with a eucapnic voluntary hyperpnoea (EVH) challenge to diagnose EIB. Players demonstrating a positive result (EVH+ ) were prescribed inhaler therapy depending on severity, including inhaled corticosteroids and inhaled short-acting β2 -agonists, and underwent repeat assessment after 9 weeks of treatment...
April 2018: ERJ Open Research
Beatriz Gullón, Gemma Eibes, Izaskun Dávila, María Teresa Moreira, Jalel Labidi, Patricia Gullón
Hydrothermal treatment is an environmentally friendly technology that allows the solubilisation of hemicellulosic oligosaccharides with potential for their use as prebiotics. The purpose of this study was to solubilize oligosaccharides and antioxidant compounds from chestnut shells by a hydrothermal processing. The highest content of oligosaccharides (18.3 g/L), with a relatively low level of monosaccharides (2.4 g/L) and degradation products (0.5 g/L) was obtained at 180 °C (severity of 3.08). In addition, the liquors presented a high content of phenolic and flavonoid compounds with good antioxidant properties...
July 15, 2018: Carbohydrate Polymers
Matteo Bonini, Omar S Usmani
Proper endotyping of EIB and precision medicine strategies would allow subjects to fully profit from the very beneficial effects of exercise, without incurring health risks or affecting performances
January 2018: ERJ Open Research
Oluwafemi Oluwole, Donna C Rennie, Ambikaipakan Senthilselvan, Roland Dyck, Anna Afanasieva, Shelley Kirychuk, George Katselis, Joshua A Lawson
BACKGROUND: Studies have reported protective and adverse associations between microbial exposure and childhood asthma. However, among children with asthma the relationships between endotoxin and exercise-induced bronchospasm (EIB) is less clear. OBJECTIVE: We investigated the association between exposure to endotoxin in house dust with atopy and EIB in children with asthma. METHODS: A cross-sectional survey was conducted among schoolchildren (aged 7-17 years) in the province of Saskatchewan, Canada...
July 2018: Environmental Research
Michael D Kennedy, Jessie M S Gill, Alastair N H Hodges
Background: Diagnosing Airway hyper-responsiveness (AHR) requires bronchial provocation tests that are performed at rest and after exercise or hyperventilation in either a lab or field setting. Presently, it is unclear whether the proposed AHR field test for swimming induces sufficient provocation due to lack of intensity. Thus we aimed to examine how the 8 minute field swim test compared to all out racing and a lower intensity practice exposure affected AHR. We hypothesized that the race would affect AHR the most thereby highlighting the importance of maximal effort in swim AHR...
June 2017: Journal of Exercise Science and Fitness
Fred H Brennan, Jeffrey Alent, Michael J Ross
Exercise-induced asthma (EIA) and exercise-induced bronchospasm (EIB)/bronchoconstriction (EIC) describes two clinical entities by which exercise triggers bronchial hyperresponsiveness. Exercise is a common trigger of bronchospasm in the asthmatic (EIA), as well as athletes without the underlying inflammation associated with asthma (EIC/EIB). Approximately 10% to 20% of the general population have EIA or EIB (). The approach to the diagnosis and subsequent management relies on the clinician's ability to recognize clinical signs and symptoms, then selecting the correct diagnostic test...
March 2018: Current Sports Medicine Reports
Constanze Eib, Claudia Bernhard-Oettel, Linda L Magnusson Hanson, Constanze Leineweber
Organizational justice perceptions are considered a predictor of health and well-being. To date, empirical evidence about whether organizational justice perceptions predict health or health predicts organizational justice perceptions is mixed. Furthermore, the processes underlying these relationships are largely unknown. In this article, we study whether bidirectional relationships can be explained by 2 different mediation mechanisms. First, based on the allostatic load model, we suggest that the relationships between organizational justice perceptions and different health indicators are mediated through mental preoccupation with work...
March 5, 2018: Journal of Occupational Health Psychology
J Zhang, Y K Fan, P Wang, Q Q Chen, G Wang, A E Xu, L Q Chen, R Hu, W Chen, Z Q Song, F Hao
BACKGROUND: China has one of the largest populations with tuberculosis worldwide. Cutaneous tuberculosis (CTB) is a rare manifestation of mycobacterial infection. Although CTB is well described, it is important to periodically revisit the prevailing clinical and epidemiological features in most populated countries such as China, India, and Indonesia, where tuberculosis is still a major health problem. OBJECTIVE: This retrospective study aimed to re-evaluate the CTB cases in China in the past 50 years to obtain a comprehensive insight into this multiplex entity...
April 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
E B Hunt, B Murphy, C Murphy, T Crowley, O Cronin, S Hay, M Stack, B Bowen, N J Ronan, E Greene, J A Eustace, B J Plant, D M Murphy
Exercise-Induced Bronchoconstriction (EIB) is an acute, transient airway narrowing occurring after exercise which may impact athletic performance. Studies report 10% of the general population and up to 90% of asthmatics experience EIB. Ninety-two players from three elite hurling squads underwent a spirometric field-based provocation test with real-time heart rate monitoring and lactate measurements to ensure adequate exertion. Players with a new diagnosis of EIB and those with a negative field-test but with a previous label of EIB or asthma underwent further reversibility testing and if negative, methacholine challenge...
December 18, 2017: Irish Medical Journal
Andréanne Côté, Julie Turmel, Louis-Philippe Boulet
Transient airway narrowing can occur during or following exercise, a phenomenon called exercise-induced bronchoconstriction (EIB). The main mechanism of EIB is considered to be airway dehydration, resulting from increased ventilation during exercise. In asthma, such water loss causes an increase in airway fluid osmolarity, inducing airway smooth muscle contraction following the release of mediators from airway inflammatory cells. Asthmatics frequently experience EIB, but it may also be observed in others not reporting asthma symptoms, particularly elite endurance athletes...
February 2018: Seminars in Respiratory and Critical Care Medicine
Georgi P Georgiev, R Shane Tubbs, Alexandar Iliev, Georgi Kotov, Boycho Landzhov
PURPOSE: The extensor indicis proprius (EIP) is a muscle of the forearm that originates from the posterior surface of the ulna and the adjacent interosseous membrane and attaches to the index finger. Many anatomical variations of this muscle have been reported in the literature. The extensor digitorum brevis manus (EDBM) is a variant muscle found on the back of the wrist and hand. These muscle variants should be considered in the context of clinical syndromes and reconstructive hand surgery...
March 2018: Surgical and Radiologic Anatomy: SRA
Karine B de Aguiar, Marina Anzolin, Linjie Zhang
AIM: This systematic review and meta-analysis aimed to estimate the global prevalence of exercise-induced bronchoconstriction (EIB) in children and adolescents. METHOD: We searched PubMed, Google Scholar, and the Virtual Health Library-BIREME from inception to December 23, 2017. We selected observational studies that reported the prevalence of EIB (diagnosed by exercise challenge test) in children and adolescents aged 5-18 years. We conducted random-effects meta-analyses to estimate the pooled prevalence of EIB and 95% CI...
April 2018: Pediatric Pulmonology
Bernd Lachmann, Rayna Sariyska, Christopher Kannen, Konrad Błaszkiewicz, Boris Trendafilov, Ionut Andone, Mark Eibes, Alexander Markowetz, Mei Li, Keith M Kendrick, Christian Montag
Virtually everybody would agree that life satisfaction is of immense importance in everyday life. Thus, it is not surprising that a considerable amount of research using many different methodological approaches has investigated what the best predictors of life satisfaction are. In the present study, we have focused on several key potential influences on life satisfaction including bottom-up and top-down models, cross-cultural effects, and demographic variables. In four independent (large scale) surveys with sample sizes ranging from N = 488 to 40,297, we examined the associations between life satisfaction and various related variables...
December 23, 2017: Behavioral Sciences
Susana Eibes, Núria Gallisà-Suñé, Miquel Rosas-Salvans, Paula Martínez-Delgado, Isabelle Vernos, Joan Roig
Centrosomes [1, 2] play a central role during spindle assembly in most animal cells [3]. In early mitosis, they organize two symmetrical microtubule arrays that upon separation define the two poles of the forming spindle. Centrosome separation is tightly regulated [4, 5], occurring through partially redundant mechanisms that rely on the action of microtubule-based dynein and kinesin motors and the actomyosin system [6]. While centrosomes can separate in prophase or in prometaphase after nuclear envelope breakdown (NEBD), prophase centrosome separation optimizes spindle assembly and minimizes the occurrence of abnormal chromosome attachments that could end in aneuploidy [7, 8]...
January 8, 2018: Current Biology: CB
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