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https://www.readbyqxmd.com/read/28938094/picky-hsp90-every-game-with-another-mate
#1
Martina Radli, Stefan G D Rüdiger
In this issue of Molecular Cell, Sahasrabudhe et al. (2017) present a dramatically renovated functional cycle for the molecular chaperone Hsp90, which stimulates re-thinking of the mechanism of this vital protein folding machine.
September 21, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28937263/imaging-features-of-breast%C3%A2-cancers-on-digital%C3%A2-breast%C3%A2-tomosynthesis%C3%A2-according-to%C3%A2-molecular%C3%A2-subtype-association-with%C3%A2-breast%C3%A2-cancer%C3%A2-detection
#2
Su Hyun Lee, Jung Min Chang, Sung Ui Shin, A Jung Chu, Ann Yi, Nariya Cho, Woo Kyung Moon
OBJECTIVE: To evaluate imaging features of breast cancers on digital breast tomosynthesis (DBT) according to molecular subtype and to determine whether the molecular subtype affects breast cancer detection on DBT. METHODS: This was an institutional review board-approved study with a waiver of informed consent. DBT findings of 288 invasive breast cancers were reviewed according to BI-RADS lexicon. Detectability of breast cancer was quantified by the number of readers (0-3) who correctly detected the cancer in an independent blinded review...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936628/the-rate-of-velocity-development-associates-with-muscle-echo-intensity-but-not-muscle-cross-sectional-area-in-older-men
#3
Jacob A Mota, Hayden K Giuliani, Gena R Gerstner, Eric D Ryan
The examination of mechanisms contributing to the age-related reductions in rapid velocity development is limited. The purpose of this study was to examine the influence of muscle cross-sectional area (CSA) and echo intensity (EI) on plantarflexor rate of velocity development (RVD) in older adults. Twenty-two men (mean ± SD age = 69 ± 3 years) performed three maximal plantarflexion voluntary isokinetic muscle actions at a velocity of 2.09 rad · s(-1). Peak RVD was determined as the peak derivative of the velocity-time curve from the onset of velocity development to the onset of the load range...
September 21, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28936543/us-li-rads-ultrasound-liver-imaging-reporting-and-data-system-for-screening-and-surveillance-of-hepatocellular-carcinoma
#4
Tara A Morgan, Katherine E Maturen, Nirvikar Dahiya, Maryellen R M Sun, Aya Kamaya
Ultrasound is the most widely used imaging tool for hepatocellular carcinoma (HCC) screening and surveillance. Until now, this method has lacked standardized guidelines for interpretation, reporting, and management recommendations [1-5]. To address this need, the American College of Radiology (ACR) has developed the Ultrasound Liver Imaging Reporting and Data System (US LI-RADS) algorithm. The proposed algorithm has two components: detection scores and visualization scores. The detection score guides management and has three categories: US-1 Negative, US-2 Subthreshold, and US-3 Positive...
September 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28936219/a-high-density-genetic-map-derived-from-rad-sequencing-and-its-application-in-qtl-analysis-of-yield-related-traits-in-vigna-unguiculata
#5
Lei Pan, Nian Wang, Zhihua Wu, Rui Guo, Xiaolu Yu, Yu Zheng, Qiuju Xia, Songtao Gui, Chanyou Chen
Cowpea [Vigna unguiculata (L.) Walp.] is an annual legume of economic importance and widely grown in the semi-arid tropics. However, high-density genetic maps of cowpea are still lacking. Here, we identified 34,868 SNPs (single nucleotide polymorphisms) that were distributed in the cowpea genome based on the RAD sequencing (restriction-site associated DNA sequencing) technique using a population of 170 individuals (two cowpea parents and 168 F2:3 progenies). Of these, 17,996 reliable SNPs were allotted to 11 consensus linkage groups (LGs)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28932985/lung-cancer-screening-with-mri-results-of-the-first-screening-round
#6
Michael Meier-Schroers, Rami Homsi, Dirk Skowasch, Jens Buermann, Matthias Zipfel, Hans Heinz Schild, Daniel Thomas
PURPOSE: To evaluate the suitability of MRI for lung cancer screening in a high-risk population. MATERIALS AND METHODS: A 5-year lung cancer screening program comparing MRI and low-dose CT (LDCT) in a high-risk population was initiated. 224 subjects were examined with MRI and LDCT. Acquired MRI sequences were T2w MultiVane XD, balanced steady-state-free precession, 3D T1w GRE, and DWI with a maximum in-room-time of 20 min. Categorization and management of nodules were based on Lung-RADS...
September 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28932980/understanding-clinical-mammographic-breast-density-assessment-a-deep-learning-perspective
#7
Aly A Mohamed, Yahong Luo, Hong Peng, Rachel C Jankowitz, Shandong Wu
Mammographic breast density has been established as an independent risk marker for developing breast cancer. Breast density assessment is a routine clinical need in breast cancer screening and current standard is using the Breast Imaging and Reporting Data System (BI-RADS) criteria including four qualitative categories (i.e., fatty, scattered density, heterogeneously dense, or extremely dense). In each mammogram examination, a breast is typically imaged with two different views, i.e., the mediolateral oblique (MLO) view and cranial caudal (CC) view...
September 20, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28929865/false-positive-screens-and-lung-cancer-risk-in-the-national-lung-screening-trial-implications-for-shared-decision-making
#8
Paul F Pinsky, Christina R Bellinger, David P Miller
Objectives Low-dose computed tomography lung cancer screening has been shown to reduce lung cancer mortality but has a high false-positive rate. The precision medicine approach to low-dose computed tomography screening assesses subjects' benefits versus harms based on their personal lung cancer risk, where harms include false-positive screens and resultant invasive procedures. We assess the relationship between lung cancer risk and the rate of false-positive LDCT screens. Methods The National Lung Screening Trial randomized high-risk subjects to three annual screens with low-dose computed tomography or chest radiographs...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28929330/development-of-a-rapid-analysis-method-for-bone-resection-margins-for-oral-squamous-cell-carcinoma-by-immunoblotting
#9
Claudia Haase, Bernd Lethaus, Ruth Knüchel-Clarke, Frank Hölzle, Angela Cassataro, Till Braunschweig
The purpose of this proof-of-principle study was to develop a rapid and approachable method to analyse bone resection margins in patients with oral squamous cell carcinoma (OSCC) in an intraoperative setting, similar to assessing frozen sections of soft tissue. Bone excision and risk of remaining tumour cells could be minimised, thus improving reconstruction measures and facilitating convalescence. Frozen, sawed wafers of porcine bone artificially combined with porcine skin (simulating OSCC properties) were used to develop and evaluate a new molecular method: protein transfer from non-decalcified, sawed wafers onto a membrane stained by immunofluorescence (Tissue-ProtTrans)...
September 19, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28929047/determining-frequency-of-genes-of-ctx-m-and-ctx-m-15-of-producing-enterobacteriaceae-of-isolated-extended-spectrum-beta-lactamases-from-clinical-samples-of-patients-referred-to-training-hospitals-of-medical-sciences-university-khorramabad-iran
#10
Seyed Mojtaba Mosavian, Azam Rezvani-Rad
OBJECTIVE: The purpose of conducting this research was evaluation of the frequency of extended-spectrum beta-lactamases (ESBLs) in separated Enterobacteriaceae isolates from clinical samples in Khorramabad city and determination of their antimicrobial resistance pattern. MATERIALS AND METHODS: In this study, 240 isolates belonging to Enterobacteriaceae family were collected in time duration between March and June in 2014. The isolates were identified by standard biochemical tests...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28926202/retinal-dysfunction-characterizes-subtypes-of-dominant-optic-atrophy
#11
Maria Lucia Cascavilla, Vincenzo Parisi, Giacinto Triolo, Lucia Ziccardi, Enrico Borrelli, Antonio Di Renzo, Nicole Balducci, Costanza Lamperti, Stefania Bianchi Marzoli, Fatima Darvizeh, Alfredo A Sadun, Valerio Carelli, Francesco Bandello, Piero Barboni
PURPOSE: To assess preganglionic retinal function using multifocal electroretinogram (mfERG) in patients affected by dominant optic atrophy (DOA) stratified by OPA1 gene mutation. METHODS: Multifocal electroretinogram (mfERG) was recorded in 18 DOA patients (DOA group, 35 eyes) and 25 age-matched healthy subjects (control group, 25 eyes). Patients were stratified in two groups based on gene mutation: missense mutation (DOA-M group, 11 eyes) and mutation causing haploinsufficiency (DOA-H group, 24 eyes)...
September 19, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28925897/role-of-apoptosis-in-the-pathogenesis-of-common-variable-immunodeficiency-cvid
#12
Mazdak Ganjalikhani-Hakemi, Reza Yazdani, Mohammad Esmaeili, Hassan Abolhassani, Wiliam Rae, Gholamreza Azizi, Majid Zaki Dizaji, Mohammadreza Shaghaghi, Faezeh Abbasi-Rad, Abbas Rezaei, Sanaz Afshar-Qasemloo, Saeed Mohammadi, Nima Rezaei, Asghar Aghamohammadi
BACKGROUND: Common variable immunodeficiency (CVID) is a heterogeneous immune deficiency characterized by hypogammaglobulinemia. Since B cell maturation and differentiation is defective in this disorder, we evaluated apoptosis in B cells of patients with CVID compared with healthy donors (HD). METHODS: Determination of peripheral blood B-cell subsets in CVID and HDs, was performed using flow cytometry. We compared total apoptosis, early apoptosis and late apoptosis/necrosis in unstimulated and stimulated B-cells of patients with CVID and HDs...
September 19, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28921850/prospective-comparison-of-transperineal-mri-ultrasound-fusion-biopsy-and-transrectal-systematic-biopsy-in-biopsy-na%C3%A3-ve-patients
#13
Angelika Borkowetz, Boris Hadaschik, Ivan Platzek, Marieta Toma, Georgi Torsev, Theresa Renner, Roman Herout, Martin Baunacke, Michael Laniado, Gustavo Baretton, Jan Philipp Radtke, Claudia Kesch, Markus Hohenfellner, Michael Froehner, Heinz-Peter Schlemmer, Manfred Wirth, Stefan Zastrow
OBJECTIVES: To evaluate the value of multiparametric magnetic resonance imaging (mpMRI) for the detection of significant prostate cancer (PCa) and to compare transperineal MRI/ultrasound-fusion biopsy (fusPbx) to conventional transrectal systematic biopsy (sysPbx) in biopsy-naïve patients. PATIENTS AND METHODS: This multicentre, prospective trial investigated biopsy-naïve patients with suspicion of PCa undergoing transperineal fusPbx in combination with transrectal sysPbx (comPbx)...
September 16, 2017: BJU International
https://www.readbyqxmd.com/read/28921530/sympatric-parallel-diversification-of-major-oak-clades-in-the-americas-and-the-origins-of-mexican-species-diversity
#14
Andrew L Hipp, Paul S Manos, Antonio González-Rodríguez, Marlene Hahn, Matthew Kaproth, John D McVay, Susana Valencia Avalos, Jeannine Cavender-Bares
Oaks (Quercus, Fagaceae) are the dominant tree genus of North America in species number and biomass, and Mexico is a global center of oak diversity. Understanding the origins of oak diversity is key to understanding biodiversity of northern temperate forests. A phylogenetic study of biogeography, niche evolution and diversification patterns in Quercus was performed using 300 samples, 146 species. Next-generation sequencing data were generated using the restriction-site associated DNA (RAD-seq) method. A time-calibrated maximum likelihood phylogeny was inferred and analyzed with bioclimatic, soils, and leaf habit data to reconstruct the biogeographic and evolutionary history of the American oaks...
September 18, 2017: New Phytologist
https://www.readbyqxmd.com/read/28919827/is-a-mechanical-assist-device-better-than-manual-chest-compression-a-randomized-controlled-trial
#15
Chaiyaporn Yuksen, Thidathit Prachanukool, Kasamon Aramvanitch, Nuttamon Thongwichit, Kittisak Sawanyawisuth, Yuwares Sittichanbuncha
BACKGROUND: Chest compression quality is a determinant of survival from sudden cardiac arrest. The CPR RsQ Assist Device (CPR RAD) is a new cardiopulmonary resuscitation device for chest compression. It is operated manually but it does not pull up on the chest on the up stroke. The aim of this study was to compare the CPR RAD with standard manual compression in terms of chest compression quality in a manikin model. METHODS: Participants were randomly assigned to either the device or manual chest compression group...
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/28919584/reduced-ifn-%C3%AE-production-in-chronic-brucellosis-patients
#16
Ehsanollah Ghaznavi Rad, Khadijeh Khosravi, Nader Zarinfar, Ghasem Mosayebi
BACKGROUND: Brucella is a well-known intracellular bacterium entailing acute and chronic illnesses in humans and domestic animals. The infection chronicity may be affected by the cell-mediated immunity and cytokine patterns. OBJECTIVE: To evaluate the patterns of T-helper cytokines in patients suffering from chronic and acute brucellosis. METHODS: In this cross-sectional study, 22 individuals with acute brucellosis, 21 individuals with chronic brucellosis, and 21 healthy individuals with the same genetic background were recruited from October 2015 to April 2016...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28918649/characterizing-verified-head-impacts-in-high-school-girls-lacrosse
#17
Shane V Caswell, Andrew E Lincoln, Hannah Stone, Patricia Kelshaw, Margot Putukian, Lisa Hepburn, Michael Higgins, Nelson Cortes
BACKGROUND: Girls' high school lacrosse players have higher rates of head and facial injuries than boys. Research indicates that these injuries are caused by stick, player, and ball contacts. Yet, no studies have characterized head impacts in girls' high school lacrosse. PURPOSE: To characterize girls' high school lacrosse game-related impacts by frequency, magnitude, mechanism, player position, and game situation. STUDY DESIGN: Descriptive epidemiology study...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28918156/exploration-of-the-bovine-colostrum-proteome-and-effects-of-heat-treatment-time-on-colostrum-protein-profile
#18
R Tacoma, S L Gelsinger, Y W Lam, R A Scuderi, D B Ebenstein, A J Heinrichs, S L Greenwood
Heat treatment of colostrum is performed on modern dairy farms to reduce pathogenic contamination before hand-feeding the colostrum to newborn calves; however, limited data are available concerning effects of heat treatment on biologically active proteins in colostrum. The objective of this exploratory study was to investigate effects of heat treatment and length of heat treatment on colostrum protein profile. Colostrum samples were collected from Holstein cows within 12 h after parturition and assigned to the following groups: heat treatment at 60°C for 0 (untreated control), 30, 60, or 90 min...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28918014/artificial-zinc-finger-transcription-factor-of-a20-suppresses-restenosis-in-sprague-dawley-rats-after-carotid-injury-via-the-ppar%C3%AE-pathway
#19
Zhaoyou Meng, Pan Gao, Lin Chen, Jing Peng, Jialu Huang, Min Wu, Kangning Chen, Zhenhua Zhou
The inhibition of inflammation and vascular smooth muscle cell (VSMC) proliferation is an ideal strategy to suppress intimal hyperplasia after percutaneous transluminal angioplasty (PTA). Evidence has indicated that overexpression of A20 suppresses neointima formation, but its low transfection efficiency limits its application. Hence, we upregulated A20 expression via transfection of rAd.ATF (recombinant adenovirus vector of artificial transcription factor) and rAd.A20 in rat carotid arteries after balloon dilatation (in vivo) and isolated VSMCs (in vitro)...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28915441/femtosecond-mega-electron-volt-electron-microdiffraction
#20
X Shen, R K Li, U Lundström, T J Lane, A H Reid, S P Weathersby, X J Wang
To understand and control the basic functions of physical, chemical and biological processes from micron to nano-meter scale, an instrument capable of visualizing transient structural changes of inhomogeneous materials with atomic spatial and temporal resolutions, is required. One such technique is femtosecond electron microdiffraction, in which a short electron pulse with femtosecond-scale duration is focused into a micron-scale spot and used to obtain diffraction images to resolve ultrafast structural dynamics over a localized crystalline domain...
September 1, 2017: Ultramicroscopy
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