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https://www.readbyqxmd.com/read/29679618/is-it-time-to-perform-only-mri-targeted-cores-our-experience-in-1032-men-submitted-to-prostate-biopsy
#1
Pietro Pepe, Antonio Garufi, Gian Domenico Priolo, Antonio Galia, Filippo Fraggetta, Michele Pennisi
PURPOSE: Diagnostic accuracy of mpMRI (multiparametric magnetic resonance imaging) in the diagnosis of clinically significant prostate cancer (csPCa) has been evaluated and compared with transperineal saturation prostate biopsy (SPBx). MATERIALS AND METHODS: From January 2011 to Febraury 2018 1032 men (median age 63 years) with median PSA of 8.6 ng/ml underwent repeat SPBx (reference test) for the suspicion of cancer. All the patients underwent 3.0 Tesla pelvic mpMRI before SPBx and the lesions with PI-RADS (Prostate Imaging-Reporting and Data System) score ≥ 3 were submitted to additional targeted fusion prostate biopsy (TPBx)...
April 18, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29677897/re-intravesical-rad-ifn%C3%AE-syn3-for-patients-with-high-grade-bacillus-calmette-guerin-refractory-or-relapsed-non-muscle-invasive-bladder-cancer-a-phase-ii-randomized-study
#2
https://www.readbyqxmd.com/read/29675659/interobserver-and-intermodality-agreement-of-standardized-algorithms-for-non-invasive-diagnosis-of-hepatocellular-carcinoma-in-high-risk-patients-ceus-li-rads-versus-mri-li-rads
#3
Barbara Schellhaas, Matthias Hammon, Deike Strobel, Lukas Pfeifer, Christian Kielisch, Ruediger S Goertz, Alexander Cavallaro, Rolf Janka, Markus F Neurath, Michael Uder, Hannes Seuss
OBJECTIVES: We compared the interobserver agreement for the recently introduced contrast-enhanced ultrasound (CEUS)-based algorithm CEUS-LI-RADS (Liver Imaging Reporting and Data System) versus the well-established magnetic resonance imaging (MRI)-LI-RADS for non-invasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients. METHODS: Focal liver lesions in 50 high-risk patients (mean age 66.2 ± 11.8 years; 39 male) were assessed retrospectively with CEUS and MRI...
April 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29675485/comparison-of-the-pregnancy-outcomes-between-the-medical-and-surgical-treatments-in-tubal-ectopi-pregnancy
#4
Azadeh Yousefnezhad, Azar Pirdehghan, Mahboubeh Roshandel Rad, Aemeh Eskandari, Shahnaz Ahmadi
Background: Various treatments have been proposed to treat ectopic pregnancy, but their impact on future pregnancies is still the subject of controversy. Objective: The aim of this study is to compare the medical and surgical treatment methods and their impact on the subsequent fertility results and complications in women with a history of ectopic pregnancy. Materials and Methods: In this analytical, cross-sectional study, 370 women with the history of ectopic pregnancy, (treared with single dose of methotrexate or salpingectomy by laparotomy), that referred to Al-Zahra Hospital, Rasht, Guilan between 2009 to 2013 were enrolled...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29674600/incidence-and-comorbidity-of-reactive-attachment-disorder-based-on-national-health-insurance-claims-data-2010-2012-in-korea
#5
Minha Hong, Duk Soo Moon, Hyejung Chang, Seung Yup Lee, Seong Woo Cho, Kyung-Sook Lee, Jin-Ah Park, Sang Min Lee, Geon Ho Bahn
Objective: We aimed to investigate the current diagnostic incidence and medical and psychiatric comorbidities of reactive attachment disorder (RAD) using the National Health Insurance Review and Assessment (HIRA) claims data. Methods: To examine the diagnostic incidence, we selected patients who were under 10-year-old and had at least one medical claim containing a 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) code for RAD (F94...
April 20, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29673997/breast-lesion-shape-and-margin-evaluation-bi-rads-based-metrics-understate-radiologists-actual-levels-of-agreement
#6
Mohammad Rawashdeh, Sarah Lewis, Maha Zaitoun, Patrick Brennan
BACKGROUND: While there is much literature describing the radiologic detection of breast cancer, there are limited data available on the agreement between experts when delineating and classifying breast lesions. The aim of this work is to measure the level of agreement between expert radiologists when delineating and classifying breast lesions as demonstrated through Breast Imaging Reporting and Data System (BI-RADS) and quantitative shape metrics. METHODS: Forty mammographic images, each containing a single lesion, were presented to nine expert breast radiologists using a high specification interactive digital drawing tablet with stylus...
April 13, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29673217/genetic-evaluation-of-natural-populations-of-the-endangered-conifer-thuja-koraiensis-using-microsatellite-markers-by-restriction-associated-dna-sequencing
#7
Lu Hou, Yanhong Cui, Xiang Li, Wu Chen, Zhiyong Zhang, Xiaoming Pang, Yingyue Li
Thuja koraiensis Nakai is an endangered conifer of high economic and ecological value in Jilin Province, China. However, studies on its population structure and conservation genetics have been limited by the lack of genomic data. Here, 37,761 microsatellites (simple sequence repeat, SSR) were detected based on 875,792 de novo-assembled contigs using a restriction-associated DNA (RAD) approach. Among these SSRs, 300 were randomly selected to test for polymorphisms and 96 obtained loci were able to amplify a fragment of expected size...
April 17, 2018: Genes
https://www.readbyqxmd.com/read/29672977/phytotherapeutics-in-cancer-invasion-and-metastasis
#8
REVIEW
Bahare Salehi, Paolo Zucca, Mehdi Sharifi-Rad, Raffaele Pezzani, Sadegh Rajabi, William N Setzer, Elena Maria Varoni, Marcello Iriti, Farzad Kobarfard, Javad Sharifi-Rad
Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29670836/construction-and-development-of-a-cardiac-tissue-specific-and-hypoxia-inducible-expression-vector
#9
Shahrooz Ghaderi, Neda Alidadiani, Jafar Soleimani Rad, Hamid Reza Heidari, Nafi Dilaver, Behzad Mansoori, Reza Rhabarghazi, Rezayat Parvizi, Vahid Khaze Shahgoli, Behzad Baradaran
Purpose: Cardiovascular gene therapy is a sophisticated approach, thanks to the safety of vectors, stable transgene expression, delivery method, and different layers of the heart. To date, numerous expression vectors have been introduced in biotechnology and biopharmacy industries in relation to genetic manipulation. Despite the rapid growth of these modalities, they must be intelligently designed, addressing the cardiac-specific transgene expression and less side effects. Herein, we conducted a pilot project aiming to design a cardiac-specific hypoxia-inducible expression cassette...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29669437/development-of-hydrogels-oleogels-and-bigels-as-local-drug-delivery-systems-for-periodontitis
#10
Rania Hamed, Ala'a AbuRezeq, Ola Tarawneh
Periodontal disease is a chronic inflammation of gum and tissues that surround and support the teeth. Nonsteroidal anti-inflammatory drugs (NSAIDs) can be used in the treatment of periodontitis to ease swelling and inflammation. One approach of treating periodontitis is loading the NSAIDs in local drug delivery systems. Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel)...
April 19, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29669013/information-dropout-patterns-in-rad-phylogenomics-and-a-comparison-with-multilocus-sanger-data-in-a-species-rich-moth-genus
#11
Kyung Min Lee, Sami M Kivelä, Vladislav Ivanov, Axel Hausmann, Lauri Kaila, Niklas Wahlberg, Marko Mutanen
A rapid shift from traditional Sanger sequencing-based molecular methods to the phylogenomic approach with large numbers of loci is underway. Among phylogenomic methods, RAD (Restriction site Associated DNA) sequencing approaches have gained much attention as they enable rapid generation of up to thousands of loci randomly scattered across the genome and are suitable for non-model species. RAD data sets however suffer from large amounts of missing data and rapid locus dropout along with decreasing relatedness among taxa...
April 14, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29667880/motion-artifacts-lesion-type-and-parenchymal-enhancement-in-breast-mri-what-does-really-influence-diagnostic-accuracy
#12
Paola Clauser, Matthias Dietzel, Michael Weber, Clemens G Kaiser, Pascal At Baltzer
Background Motion artifacts can reduce image quality of breast magnetic resonance imaging (MRI). There is a lack of data regarding their effect on diagnostic estimates. Purpose To evaluate factors that potentially influence readers' diagnostic estimates in breast MRI: motion artifacts; amount of fibroglandular tissue; background parenchymal enhancement; lesion size; and lesion type. Material and Methods This Institutional Review Board-approved, retrospective, cross-sectional, single-center study included 320 patients (mean age = 55...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29667616/using-the-prostate-imaging-reporting-and-data-system-version-2-pi-rids-v2-to-detect-prostate-cancer-can-prevent-unnecessary-biopsies-and-invasive-treatment
#13
Chang Liu, Shi-Liang Liu, Zhi-Xian Wang, Kai Yu, Chun-Xiang Feng, Zan Ke, Liang Wang, Xiao-Yong Zeng
Prostate cancer (PCa) is one of the most common cancers among men globally. The authors aimed to evaluate the ability of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) to classify men with PCa, clinically significant PCa (CSPCa), or no PCa, especially among those with serum total prostate-specific antigen (tPSA) levels in the "gray zone" (4-10 ng ml-1 ). A total of 308 patients (355 lesions) were enrolled in this study. Diagnostic efficiency was determined. Univariate and multivariate analyses, receiver operating characteristic curve analysis, and decision curve analysis were performed to determine and compare the predictors of PCa and CSPCa...
April 13, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29667373/heritability-estimates-from-genome-wide-relatedness-matrices-in-wild-populations-application-to-a-passerine-using-a-small-sample-size
#14
C Perrier, B Delahaie, A Charmantier
Genomic developments have empowered the investigation of heritability in wild populations directly from genome wide relatedness matrices (GRM). Such GRM based approaches can in particular be used to improve or substitute approaches based on social pedigree (PED-social). However, measuring heritability from GRM in the wild has not been widely applied yet, especially using small samples and in non-model species. Here, we estimated heritability for four quantitative traits (tarsus length, wing length, bill length and body mass), using PED-social, a pedigree corrected by genetic data (PED-corrected) and a GRM from a small sample (n = 494) of blue tits from natural populations in Corsica genotyped at nearly 50,000 filtered SNPs derived from RAD-seq...
April 17, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29666558/verification-of-a-novel-point-of-care-hba-1c-device-in-real-world-clinical-practice-by-comparison-to-three-high-performance-liquid-chromatography-instruments
#15
Yufei Wang, Wei Peng, Junling Tang, Lu Dong, Chengchen Gu, Xin Zhang, Jian Zhou, Weiping Jia
Introduction: A real world clinical study was designed and conducted to evaluate the performance of a novel point-of-care device for determination of glycated haemoglobin A1c (HbA1c ), A1C EZ 2.0, in daily clinical practice. Materials and methods: Five hundred and fourteen subjects were included in this study, and divided into three groups. HbA1c was measured by A1C EZ 2.0 and three different high performance liquid chromatography (HPLC) devices: Bio-Rad Variant II Turbo, Tosoh HLC-723 G8 and Premier Hb9210 separately...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29666297/phase-ii-study-of-everolimus-in-metastatic-malignant-melanoma-ncctg-n0377-alliance
#16
Jesus Vera Aguilera, Ravi D Rao, Jacob B Allred, Vera J Suman, Harold E Windschitl, Judith S Kaur, William J Maples, Val J Lowe, Edward T Creagan, Lori A Erickson, Svetomir Markovic
LESSONS LEARNED: Everolimus does not have sufficient activity to justify its use as single agent in metastatic melanoma.Patients treated with 10 mg per day dose were most likely to require dose reductions.Everolimus appeared to reduce the numbers of regulatory T cells in approximately half of the treated patients; unfortunately, these effects were not correlated with clinical outcomes. BACKGROUND: Everolimus (RAD-001) is an orally active rapamycin analogue shown in preclinical data to produce cytostatic cell inhibition, which may be potentially beneficial in treating melanoma...
April 17, 2018: Oncologist
https://www.readbyqxmd.com/read/29665024/micrornas-mapping-out-the-road-to-als
#17
EDITORIAL
Nassim Rad, Michael D Weiss
No abstract text is available yet for this article.
April 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29664342/downgrading-of-breast-masses-suspicious-for-cancer-by-using-optoacoustic-breast-imaging
#18
Gisela L G Menezes, Ruud M Pijnappel, Carla Meeuwis, Robertus Bisschops, Jeroen Veltman, Philip T Lavin, Marc J van de Vijver, Ritse M Mann
Purpose To assess the ability of optoacoustic (OA) ultrasonography (US) to help correctly downgrade benign masses classified as Breast Imaging Reporting and Data System (BI-RADS) 4a and 4b to BI-RADS 3 or 2. Materials and Methods OA/US technology uses laser light to detect relative amounts of oxygenated and deoxygenated hemoglobin in and around suspicious breast masses. In this prospective, multicenter study, results of 209 patients with 215 breast masses classified as BI-RADS 4a or 4b at US are reported. Patients were enrolled between 2015 and 2016...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29664338/impact-of-clinical-history-on-maximum-pi-rads-version-2-score-a-six-reader-120-case-sham-history-retrospective-evaluation
#19
Prasad R Shankar, Ravi K Kaza, Mahmoud M Al-Hawary, William R Masch, Nicole E Curci, Mishal Mendiratta-Lala, Michelle D Sakala, Timothy D Johnson, Matthew S Davenport
Purpose To assess the impact of clinical history on the maximum Prostate Imaging Recording and Data System (PI-RADS) version 2 (v2) score assigned to multiparametric magnetic resonance (MR) imaging of the prostate. Materials and Methods This retrospective cohort study included 120 consecutively selected multiparametric prostate MR imaging studies performed between November 1, 2016, and December 31, 2016. Sham clinical data in four domains (digital rectal examination, prostate-specific antigen level, plan for biopsy, prior prostate cancer history) were randomly assigned to each case by using a balanced orthogonal design...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29661602/automated-breast-ultrasound-interpretation-times-a-reader-performance-study
#20
Ashley I Huppe, Marc F Inciardi, Mark Redick, Melissa Carroll, Jennifer Buckley, Jacqueline D Hill, Jason B Gatewood
RATIONALE AND OBJECTIVES: This study aimed to determine the average time for breast radiologists of varied experience to interpret automated breast ultrasound (ABUS) examinations. MATERIALS AND METHODS: A reader performance study was conducted on female patients, with ACR BI-RADS 4 breast density classifications of C or D, who received both an ABUS screening examination and a digital mammogram from 2013 to 2014 at an academic institution. Three faculty breast radiologists with varied levels of ABUS experience (advanced, intermediate, novice) read all ABUS examinations, with interpretation times and final impressions (categorized as "normal" or "abnormal") recorded for each examination...
April 13, 2018: Academic Radiology
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