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https://www.readbyqxmd.com/read/29470623/long-distance-longitudinal-prostate-mri-quality-assurance-from-startup-to-12-months
#1
Nicole E Curci, Patrick Gartland, Prasad R Shankar, Jeffrey S Montgomery, David C Miller, Arvin K George, Matthew S Davenport
PURPOSE: To evaluate a 12-month long-distance prostate MRI quality assurance (QA) program. METHODS: The need for IRB approval was waived for this prospective longitudinal QA effort. One academic institution experienced with prostate MRI [~ 1000 examinations/year (Site 2)] partnered with a private institution 240 miles away that was starting a new prostate MRI program (Site 1). Site 1 performed all examinations (N = 249). Four radiologists at Site 1 created finalized reports, then sent images and reports to Site 2 for review on a rolling basis...
February 22, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29469852/air-wedge-with-variable-refractive-index-for-precise-laser-beam-steering-in-a-small-range
#2
Olga Iwasińska-Kowalska
This paper provides the results of work on a new method for metrological laser beam steering for the purpose of angular stabilization. Frequency stabilized metrological lasers are used for interference measurements of length and angle. Angular deviation of the beam may cause cosine errors when measuring displacements. This paper presents a method for metrological laser beam deflection with an air wedge of variable refractive index. The change in the index is achieved by changing the air pressure in the wedge volume...
February 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29468047/exploring-the-phylogeography-of-a-hexaploid-freshwater-fish-by-rad-sequencing
#3
Connor Seamus Stobie, Carel J Oosthuizen, Michael J Cunningham, Paulette Bloomer
The KwaZulu-Natal yellowfish ( Labeobarbus natalensis ) is an abundant cyprinid, endemic to KwaZulu-Natal Province, South Africa. In this study, we developed a single-nucleotide polymorphism (SNP) dataset from double-digest restriction site-associated DNA (ddRAD) sequencing of samples across the distribution. We addressed several hidden challenges, primarily focusing on proper filtering of RAD data and selecting optimal parameters for data processing in polyploid lineages. We used the resulting high-quality SNP dataset to investigate the population genetic structure of L...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29467588/pulmonary-arterial-enlargement-is-associated-with-acute-chest-pain-in-patients-without-obstructive-coronary-artery-disease
#4
Narasa Madam, Wassim Mosleh, Natdanai Punnanithinont, Andres Carmona-Rubio, Zaid H Said, Umesh C Sharma
Background: Pulmonary hypertension (PH) is an underdiagnosed cause for chest pain in patients without significant coronary artery disease (CAD). Studies showed that enlarged pulmonary arterial (PA) and right ventricular chamber sizes correlate with the severity of PH. Therefore, we studied the association between chest pain, right ventricular dimensions (RVDs), and PA size on coronary coronary tomographic angiography (CCTA). Methods: The CCTA of 87 patients presenting with chest pain without evidence of obstructive CAD was examined...
2018: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/29465980/reductive-amination-combining-dimethylation-for-quantitative-analysis-of-early-stage-glycated-proteins
#5
Qing-He Tong, Tian-Yang Yan, Tao Tao, Lei Zhang, Li-Qi Xie, Haojie Lu
Due to the critical role glycation plays in many serious pathological conditions, such as diabetes, it is of great significance to discov-er protein glycation at early stage for precaution and prediction of the disease. Here, a method of reductive amination combining dimethylation (RAD) was developed for the quantification of early stage glycated proteins. The quantitative analysis was first car-ried out by reducing the samples using NaBH3CN or NaBD3CN, resulting in 1 Da mass shift and the stabilization of early stage pro-tein glycation...
February 21, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29464748/prospective-randomized-study-evaluating-ultrasound-versus-fluoroscopy-guided-sacral-interstim%C3%A2-lead-placement-a-pilot-study
#6
Jaschar Shakuri-Rad, Arman Cicic, Jannah Thompson
OBJECTIVE: To investigate the use of intraoperative ultrasound during stage I InterStim® sacral lead placement. METHODS: A total of 40 patients were randomly assigned to undergo InterStim® lead placement utilizing fluoroscopy or ultrasound guidance. Patients were blinded for the duration of the study. The surgeon and staff were blinded until after induction of anesthesia. Patients met criteria for refractory overactive bladder, fecal incontinence, or both. The ICIQ-OABqol, OABSS, and FIQL validated questionnaires were used pre- and post-operatively...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29463881/stroma-modifies-relationships-between-risk-factor-exposure-and-age-related-epithelial-involution-in-benign-breast
#7
Lynn Chollet-Hinton, Samantha Puvanesarajah, Rupninder Sandhu, Erin L Kirk, Bentley R Midkiff, Karthik Ghosh, Kathleen R Brandt, Christopher G Scott, Gretchen L Gierach, Mark E Sherman, Celine M Vachon, Melissa A Troester
Delayed age-related lobular involution has been previously associated with elevated breast cancer risk. However, intraindividual variability in epithelial involution status within a woman is undefined. We developed a novel measure of age-related epithelial involution, density of epithelial nuclei in epithelial areas using digital image analysis in combination with stromal characteristics (percentage of section area comprising stroma). Approximately 1800 hematoxylin and eosin stained sections of benign breast tissue were evaluated from 416 participants having breast surgery for cancer or benign conditions...
February 20, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29463177/the-combination-of-targeted-and-systematic-prostate-biopsies-is-the-best-protocol-for-the-detection-of-clinically-significant-prostate-cancer
#8
Alexandre Fourcade, Charlotte Payrard, Valentin Tissot, Marie-Aimée Perrouin-Verbe, Nicolas Demany, Sophie Serey-Effeil, Pierre Callerot, Jean-Baptiste Coquet, Laurent Doucet, Charles Deruelle, Vincent Joulin, Michel Nonent, Georges Fournier, Antoine Valeri
OBJECTIVE: Compared with standard systematic transrectal ultrasound (TRUS)-guided biopsies (SBx), targeted biopsies (TBx) using magnetic resonance imaging (MRI)/TRUS fusion could increase the detection of clinically significant prostate cancer (PCa-s) and reduce non-significant PCa (PCa-ns). This study aimed to compare the performance of the two approaches. MATERIALS AND METHODS: A prospective, single-center study was conducted on all consecutive patients with PCa suspicion who underwent prebiopsy multiparametric MRI (mpMRI) using the Prostate Imaging Reporting and Data System (PI-RADS)...
February 20, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29462667/a-proximity-extension-assay-pea-based-method-for-quantification-of-bevacizumab
#9
Ivana Mikačić, Robert Belužić, Oliver Vugrek, Đuro Plavljanić
INTRODUCTION: Proximity Extension Assay (PEA) is a direct one-step protein quantification method using a pair of DNA oligonucleotides linked to antibodies against the target molecule. It requires polyclonal or two monoclonal antibodies (mAbs) that bind to target epitopes close enough to form a DNA duplex which is quantified by real-time PCR. Bevacizumab, an anti-cancer drug, is a mAb against vascular endothelial growth factor with common cardiovascular adverse effects. It is widely used off-label to treat neovascular eye disorders by intravitreal application of small doses...
February 17, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29461172/radiomics-based-on-adapted-diffusion-kurtosis-imaging-helps-to-clarify-most-mammographic-findings-suspicious-for-cancer
#10
Sebastian Bickelhaupt, Paul Ferdinand Jaeger, Frederik Bernd Laun, Wolfgang Lederer, Heidi Daniel, Tristan Anselm Kuder, Lorenz Wuesthof, Daniel Paech, David Bonekamp, Alexander Radbruch, Stefan Delorme, Heinz-Peter Schlemmer, Franziska Hildegard Steudle, Klaus Hermann Maier-Hein
Purpose To evaluate a radiomics model of Breast Imaging Reporting and Data System (BI-RADS) 4 and 5 breast lesions extracted from breast-tissue-optimized kurtosis magnetic resonance (MR) imaging for lesion characterization by using a sensitivity threshold similar to that of biopsy. Materials and Methods This institutional study included 222 women at two independent study sites (site 1: training set of 95 patients; mean age ± standard deviation, 58.6 years ± 6.6; 61 malignant and 34 benign lesions; site 2: independent test set of 127 patients; mean age, 58...
February 20, 2018: Radiology
https://www.readbyqxmd.com/read/29460074/the-role-of-breast-tomosynthesis-in-a-predominantly-dense-breast-population-at-a-tertiary-breast-centre-breast-density-assessment-and-diagnostic-performance-in-comparison-with-mri
#11
Daniel Förnvik, Masako Kataoka, Mami Iima, Akane Ohashi, Shotaro Kanao, Masakazu Toi, Kaori Togashi
OBJECTIVES: To compare breast density measured on digital breast tomosynthesis (DBT) (BI-RADS-based breast composition and fully-automatic estimation) and magnetic resonance imaging (MRI) (BI-RADS amount of fibroglandular tissue), and to evaluate the diagnostic performance in terms of sensitivity and specificity of DBT and MRI in a predominantly dense breast population. METHODS: Between 2015 and 2016, 152 women with 103 breast malignancies, who underwent 3-T breast MRI and DBT within 2 months' time, were enrolled in this study...
February 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29457964/liver-imaging-reporting-and-data-system-patient-outcomes-for-category-4-and-5-nodules
#12
Sang Hyun Choi, Jae Ho Byun, Young-Suk Lim, So Jung Lee, So Yeon Kim, Hyung Jin Won, Yong Moon Shin, Pyo-Nyun Kim
Purpose To determine the outcomes after initial therapy in patients with chronic liver disease and retrospectively assigned Liver Imaging Reporting and Data System (LI-RADS; version 2014) category 4 (LR-4) and 5 (LR-5) nodules at gadoxetate disodium-enhanced MR imaging. Materials and Methods In this retrospective study, 260 patients with a single LR-4 (n = 132) or LR-5 (n = 128) nodule who were assigned a LI-RADS category were included. Patients were identified between January 2012 and December 2012, and were initially treated by resection, liver transplant, radiofrequency ablation (RFA), or transcatheter arterial chemoembolization (TACE) according to the Barcelona Clinic Liver Cancer staging system...
February 19, 2018: Radiology
https://www.readbyqxmd.com/read/29457927/structural-fingerprints-interactions-and-signaling-networks-of-ras-family-proteins-beyond-ras-isoforms
#13
Saeideh Nakhaei-Rad, Fereshteh Haghighi, Parivash Nouri, Soheila Rezaei Adariani, Jana Lissy, Neda S Kazemein Jasemi, Radovan Dvorsky, Mohammad Reza Ahmadian
No abstract text is available yet for this article.
February 19, 2018: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29457229/radiomics-analysis-of-pulmonary-nodules-in-low-dose-ct-for-early-detection-of-lung-cancer
#14
Wookjin Choi, Jung Hun Oh, Sadegh Riyahi, Chia-Ju Liu, Feng Jiang, Wengen Chen, Charles White, Andreas Rimner, James G Mechalakos, Joseph O Deasy, Wei Lu
PURPOSE: To develop a radiomics prediction model to improve pulmonary nodule (PN) classification in low-dose CT. To compare the model with the American College of Radiology (ACR) Lung CT Screening Reporting and Data System (Lung-RADS) for early detection of lung cancer. METHODS: We examined a set of 72 PNs (31 benign and 41 malignant) from the Lung Image Database Consortium image collection (LIDC-IDRI). 103 CT radiomic features were extracted from each PN. Before the model building process, distinctive features were identified using a hierarchical clustering method...
February 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/29456204/renoprotective-effect-of-nigella-sativa-against-cisplatin-induced-nephrotoxicity-and-oxidative-stress-in-rat
#15
Sara Hosseinian, Mousa-Al-Reza Hadjzadeh, Noma Mohamadian Roshan, Majid Khazaei, Samira Shahraki, Reza Mohebbati, Abolfazl Khajavi Rad
Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. sativa) is an herbaceous plant with many pharmacologic effects. In the present study, we evaluated the protective effects of aqueous-ethanolic extract of N. sativa and Vitamin E on cisplatin-induced nephrotoxicity in rats. Eighty male rats were divided into eight groups: control, cisplatin (6 mg/kg; ip), preventive Vitamin E (100 mg/kg), preventive N. sativa (100,200 mg/kg), preventive + treatment Vitamin E, and preventive + treatment N...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29455934/corrigendum-to-low-molar-excess-of-4-oxo-2-nonenal-and-4-hydroxy-2-nonenal-promote-oligomerization-of-alpha-synuclein-through-different-pathways-free-rad-biol-med-2017-421-431
#16
Leire Almandoz-Gil, Hedvig Welander, Elisabeth Ihse, Payam Emami Khoonsari, Sravani Musunuri, Christofer Lendel, Jessica Sigvardson, Mikael Karlsson, Martin Ingelsson, Kim Kultima, Joakim Bergström
No abstract text is available yet for this article.
February 15, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29455537/synthesis-and-biophysical-characterization-of-an-odd-numbered-1-3-diamidophospholipid
#17
Frederik Neuhaus, Dennis Mueller, Radu Tanasescu, Sandor Balog, Takashi Ishikawa, Gerald Brezesinski, Andreas Zumbuehl
Nanomedicine suffers from low drug delivery efficiencies. Mechanoresponsive vesicles could provide an alternative way to release active compounds triggered by the basic physics of the human body. 1,3-Diamidophospholipids with C16 tails proved to be an effective building block for mechanoresponsive vesicles, but their low main phase transition temperature prevents an effective application in humans. As the main phase transition temperature of a membrane depends on the fatty acyl chain length we synthesized a C17 homologue of a 1,3-diamidophospholipid: Rad-PC-Rad...
February 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29455472/double-digest-rad-sequencing-outperforms-microsatellite-loci-at-assigning-paternity-and-estimating-relatedness-a-proof-of-concept-in-a-highly-promiscuous-bird
#18
Derrick J Thrasher, Bronwyn G Butcher, Leonardo Campagna, Michael S Webster, Irby J Lovette
Information on genetic relationships among individuals is essential to many studies of the behavior and ecology of wild organisms. Parentage and relatedness assays based on large numbers of SNP loci hold substantial advantages over the microsatellite markers traditionally used for these purposes. We present a double-digest restriction site-associated DNA sequencing (ddRAD-seq) analysis pipeline that, as such, simultaneously achieves the SNP discovery and genotyping steps and which is optimized to return a statistically powerful set of SNP markers (typically 150-600 after stringent filtering) from large numbers of individuals (up to 240 per run)...
February 17, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29453458/il-2-inducible-kinase-itk-is-critical-for-hiv-1-infection-of-jurkat-t-cells
#19
Anika Hain, Melanie Krämer, René M Linka, Saeideh Nakhaei-Rad, Mohammad Reza Ahmadian, Dieter Häussinger, Arndt Borkhardt, Carsten Münk
Successful replication of Human immunodeficiency virus (HIV)-1 depends on the expression of various cellular host factors, such as the interleukin-2 inducible T-cell kinase (ITK), a member of the protein family of TEC-tyrosine kinases. ITK is selectively expressed in T-cells and coordinates signaling pathways downstream of the T-cell receptor and chemokine receptors, including PLC-1 activation, Ca 2+ -release, transcription factor mobilization, and actin rearrangements. The exact role of ITK during HIV-1 infection is still unknown...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29451396/vacuum-assisted-breast-biopsy-vab-excision-of-subcentimeter-microcalcifications-as-an-alternative-to-open-biopsy-for-atypical-ductal-hyperplasia
#20
Schiaffino Simone, Massone Elena, Gristina Licia, Fregatti Piero, Rescinito Giuseppe, Alessandro Villa, Friedman Daniele, Calabrese Massimo
OBJECTIVE: To report the results of the conservative management with mammographic checks of patients with ADH diagnosed by vacuum assisted breast biopsy (VAB), without residual calcifications. METHODS: The authors accessed the institutional database of radiological, surgical and pathologic anatomy. Inclusion criteria were: ADH diagnosed by VAB on a single group of microcalcifications, without residual post-procedure; follow-up at least of 12 months. Exclusion criteria were the presence of personal history of breast cancer or other high risk lesions; association with other synchronous lesions, both more and less advanced proliferative lesions...
February 16, 2018: British Journal of Radiology
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