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Larynx squamous cell carcinoma

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https://www.readbyqxmd.com/read/30333880/the-role-of-protein-p16-ink4a-in-non-oropharyngeal-head-and-neck-squamous-cell-carcinoma-in-southern-china
#1
Hang Yang, Ye Cao, Zhi-Ming Li, Ya-Jun Li, Wen-Qi Jiang, Yan-Xia Shi
Cyclin-dependent kinase inhibitor 2A (p16INK4a ) protein is a surrogate immunohistochemical marker of human papillomavirus infection in oropharynx squamous cell carcinoma (OPSCC). However, the effects of p16INK4a in non-OPSCC require additional analysis. In addition, major gaps remain in the literature, including small volumes of data for China. Therefore, the present study evaluated the frequency of p16INK4a positivity in patients with non-OPSCC in Southern China, and assessed its prognostic value. p16INK4a expression status in patients with non-OPSCC was determined by immunohistochemistry...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30332498/survival-of-patients-with-head-and-neck-cancer-treated-with-definitive-radiotherapy-and-concurrent-cisplatin-or-concurrent-cetuximab-a-surveillance-epidemiology-and-end-results-medicare-analysis
#2
Michael Xiang, F Christopher Holsinger, A Dimitrios Colevas, Michelle M Chen, Quynh-Thu Le, Beth M Beadle
BACKGROUND: Cisplatin and cetuximab are both systemic therapies commonly used in combination with radiation (RT) for the definitive treatment of head and neck cancers, but their comparative efficacy is unclear. METHODS: Patients with locoregionally advanced (American Joint Committee on Cancer stage III-IVB) squamous cell carcinomas of the oropharynx, larynx, or hypopharynx were identified in the Surveillance, Epidemiology, and End Results-Medicare database. Patients received either cisplatin or cetuximab concurrent with RT, as determined by Medicare claims...
October 17, 2018: Cancer
https://www.readbyqxmd.com/read/30324779/dysplastic-changes-in-patients-with-recurrent-laryngeal-leukoplakia-importance-of-long-term-follow-up
#3
Basel Jabarin, Jacob Pitaro, Tal Marom, Limor Muallem-Kalmovich
BACKGROUND: Leukoplakia of the vocal cords may represent a pre-cancerous lesion of the larynx. The management of cases of recurrent leukoplakia with pathologically proven dysplasia is still controversial. OBJECTIVES: To present a series of patients with recurrent vocal cord leukoplakia and to examine their malignant transformation rate in relation to the clinical characteristics, risk factors, and histological findings. METHODS: A retrospective cohort study was conducted between 1999 and 2017...
October 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/30311577/surveillance-of-hpv-positive-head-and-neck-squamous-cell-carcinoma-with-circulating-and-salivary-dna-biomarkers
#4
Daniele Borsetto, Jordan Cheng, Karl Payne, Paul Nankivell, Nikolas Batis, Kanishka Rao, Shreerang Bhide, Feng Li, Yong Kim, Hisham Mehanna, David Wong
Head and neck squamous cell carcinoma (HNSCC) manifests in the mucosal epithelial lining of the oral cavity, oropharynx, hypopharynx, nasopharynx or larynx and has a tremendous disease burden worldwide. Smoking and alcohol consumption were once major risk factors, but HPV-associated infection has emerged as the major contributor to HNSCC occurrence in developed countries. Circulating biomarker evaluations in biofluids, also known as liquid biopsy, are an attractive alternative for cancer screening as they are minimally invasive, potentially low cost, and easily repeatable on a serial basis...
2018: Critical Reviews in Oncogenesis
https://www.readbyqxmd.com/read/30282158/-primary-laryngeal-non-hodgkin-s-lymphoma-a-case-report
#5
Q R Chen, H Yang, D Lv
Non-Hodgkin' s lymphoma is a kind of disease which might manifest in varied form. Unlike squamous cell carcinoma, the majority of laryngeal tumors, non-Hodgkin' s lymphoma in larynx is extremely rare. Here we present a primary laryngeal non-Hodgkin' s lymphoma, a 66-year-old female, with a history of recurrent sore throat and hoarseness for over 1 year. Laryngoscope and computed tomography result were presented, and surgical resection was performed under the suspension laryngoscope using CO₂ laser. According to the pathological immunohistochemistry result, the final diagnosis was laryngeal non-Hodgkin' s lymphoma...
August 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/30271885/hpv-impacts-survival-of-stage-ivc-non-oropharyngeal-hnscc-cancer-patients
#6
Adam R Burr, Paul M Harari, Huaising C Ko, Shuai Chen, Menggang Yu, Andrew M Baschnagel, Randall J Kimple, Matthew E Witek
Objectives: Human papillomavirus (HPV) status is a favorable prognostic marker for patients with oropharyngeal squamous cell carcinoma (OPSCC) and non-metastatic head and neck non-OPSCC. We evaluated the impact of HPV status on overall survival (OS) for patients with Stage IVC non-OPSCC. Materials and methods: Patients diagnosed with Stage IVC non-OPSCC and known HPV status between 2010-2013 were identified in the National Cancer Database. Univariate and multivariate analyses were performed to determine factors associated with OS...
2018: Otorhinolaryngology-Head and Neck Surgery
https://www.readbyqxmd.com/read/30256015/presence-of-helicobacter-pylori-in-the-stomach-and-laryngeal-mucosal-linings-in-patients-with-laryngeal-cancer
#7
Ivana Pajić Matić, Davor Jelić, Ivo Matić, Siniša Maslovara, Tihana Mendeš
Helicobacter (H.) pylori is the cause of one of the most common chronic bacterial infections in humans. Risk factors for the development of laryngeal cancer are cigarette smoke, alcohol, and human papillomavirus. Several papers report on H. pylori isolated in tooth plaque, saliva, middle ear and sinuses. Many articles describe the presence of H. pylori in laryngeal cancer cases, however, without noting the possible source of infection, i.e. stomach or oral cavity. The aim of this study was to determine which patients and to what extent simultaneously developed H...
March 2018: Acta Clinica Croatica
https://www.readbyqxmd.com/read/30250544/transforming-growth-factor-%C3%AE-signaling-in-head-and-neck-squamous-cell-carcinoma-insights-into-cellular-responses
#8
REVIEW
Xin Pang, Ya-Ling Tang, Xin-Hua Liang
Head and neck squamous cell carcinoma (HNSCC) arises in the oral cavity, salivary glands, larynx, pharynx, nasal cavity and paranasal sinuses, and is characterized by high morbidity and metastasis rates. Transforming growth factor-β (TGF-β) is a homodimeric protein known to be a multifunctional regulator in target cells and to serve a pivotal role in numerous types of cancer, including HNSCC. The role of TGF-β signaling in carcinogenesis can change from tumor-suppressing to tumor-promoting. In addition, TGF-β induces epithelial-mesenchymal transition and restrains immune surveillance on malignant cells...
October 2018: Oncology Letters
https://www.readbyqxmd.com/read/30241033/laryngeal-sarcomas-a-case-series-of-5-cases
#9
Badr AbdullGaffar, Tasnim Keloth
Primary sarcomas of the larynx are rare and miscellaneous. The most common is chondrosarcoma. Other sarcomas are very rare. Sarcomas can have heterogeneous morphologic features of spindle, small round, epithelioid, pleomorphic and giant cells. Laryngeal sarcomas may mimic carcinomas, lymphomas, small cell carcinoma, mesothelioma and melanoma. This imposes diagnostic challenges for unfamiliar pathologists particularly in small laryngeal biopsies. Our aim was to study the different types of sarcomas that can involve the larynx in our institution, to investigate their diagnostic challenges and potential pitfalls and to find helpful histologic clues to avoid misinterpretation and missed diagnosis...
September 14, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/30239887/cisplatin-every-3-weeks-versus-weekly-with-definitive-concurrent-radiotherapy-for-squamous-cell-carcinoma-of-the-head-and-neck
#10
Joshua M Bauml, Ravi Vinnakota, Yeun-Hee Anna Park, Susan E Bates, Tito Fojo, Charu Aggarwal, Sewanti Limaye, Nevena Damjanov, Jessica Di Stefano, Christine Ciunci, Eric M Genden, Juan P Wisnivesky, Rocco Ferrandino, Ronac Mamtani, Corey J Langer, Roger B Cohen, Keith Sigel
Background: Concurrent chemoradiotherapy is an established component of the nonoperative management of locally advanced head and neck squamous cell carcinoma (HNSCC), but the standard dose of 100 mg/m2 cisplatin every 3 weeks is associated with clinically significant toxicity. Interest in a more tolerable regimen has led to the widespread use of weekly lower dose cisplatin, but few randomized trials have compared these approaches. Methods: We examined outcomes of patients with stage III-IVb HNSCC treated with definitive intent chemoradiotherapy using either high-dose cisplatin (HDC) or low-dose cisplatin (LDC), using population-based Veterans Affairs data...
September 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30231315/personalizing-postoperative-treatment-of-head-and-neck-cancers
#11
Ellie Maghami, Shlomo A Koyfman, Jared Weiss
Head and neck cancer (HNC) treatment is a complex multidisciplinary undertaking. Although overtreatment can result in functional and cosmetic defects, undertreatment can result in cancer recurrence. Surgery and chemoradiotherapy are both accepted standards for the curative intent treatment of locally advanced mucosal squamous cell carcinoma of the head and neck, but are often prioritized differently depending on the site of tumor origin (e.g., oral cavity/sinonasal vs. oropharynx/larynx), tumor burden, tumor biology, quality-life considerations, and patient preference...
May 23, 2018: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/30221531/epidemiology-of-head-and-neck-cancers-in-northern-iran-a-10-year-trend-study-from-golestan-province
#12
Mohammad-Hossein Taziki, Abdolreza Fazel, Fatemeh Salamat, Seyed-Mehdi Sedaghat, Mohammad Ashaari, Hossein Poustchi, Ramin Shakeri, Reza Hoseinpoor, Susan Hasanpour-Heidari, Gholamreza Roshandel
BACKGROUND: Golestan province, in Northern Iran, is a high-risk area for esophageal squamous cell carcinoma (SCC). SCC is also the most common histological type of cancers of the head and neck region including cancers of oral cavity, oropharynx, hypopharynx and larynx. We aimed to present the incidence rate of head and neck SCC (HNSCC) in Golestan province during 2004 and 2013. METHODS: Data on HNSCC were obtained from Golestan population-based cancer registry (GPCR)...
September 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/30220121/-significance-of-hpv-and-cell-cycle-related-proteins-in-basaloid-squamous-cell-carcinoma-of-the-larynx
#13
L F Cui, H Chang, H Y Zhao, C L Qu, Y Gao, H G Liu
Objective: To study the significance of HPV and cell cycle related proteins in basaloid squamous cell carcinoma (BSCC) of the larynx. Methods: Twenty-nine cases of laryngeal BSCC from Beijing Tongren Hospital from January 2005 to December 2011 were reviewed. HPV typing by polymerase chain reaction-reverse dot blot (PCR-RDB) and p53, Ki-67, p16, p21 and cyclin D1 expression by immunohistochemistry were performed. The relationship between these indicators, various pathologic parameters (TNM, tumor size, tumor site and lymph node metastasis) and HPV status was analyzed...
September 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/30174259/nodal-metastases-distribution-in-laryngeal-cancer-requiring-total-laryngectomy-therapeutic-implications-for-the-n0-neck
#14
D Riviere, J Mancini, L Santini, A Loth Bouketala, A Giovanni, P Dessi, N Fakhry
OBJECTIVES: Neck dissection is a controversial surgical procedure in patients with squamous cell carcinoma of the Larynx free of any node metastasis detected in preoperative staging. The aim of this study was to investigate the distributions of lymph node metastases in laryngeal squamous cell carcinoma and improve the rationale for elective treatment of N0 neck. MATERIAL AND METHODS: Retrospective single-center series of Seventy-eight successive patients with laryngeal squamous cell carcinoma who underwent neck dissection between 2008 and 2015...
August 30, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/30138436/expression-of-immunohistochemical-markers-in-non-oropharyngeal-head-and-neck-squamous-cell-carcinoma-in-ghana
#15
Osei Owusu-Afriyie, W K B A Owiredu, Kwabena Owusu-Danquah, Rita Larsen-Reindorf, Peter Donkor, Emmanuel Acheampong, Solomon E Quayson
BACKGROUND: Head and neck cancers include carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx. Studies on molecular expression of prognostic tumour markers in Ghana are scarce. The purpose of this study was to determine the expression of p53, p16, EGFR, Cyclin-D1 and HER2 among patients with non-oropharyngeal head and neck squamous cell carcinoma (HNSCC). METHODOLOGY: Tissue microarrays from 154 histologically confirmed non-oropharyngeal HNSCC at the Komfo Anokye Teaching Hospital from 2006-2014 were constructed using duplicate cores of representative and viable areas from tumours...
2018: PloS One
https://www.readbyqxmd.com/read/30134232/prevalence-and-prognostic-significance-of-hpv-in-laryngeal-squamous-cell-carcinoma-in-northeast-china
#16
Fangjia Tong, Jingshu Geng, Bingqing Yan, Huihuang Lou, Xiaohang Chen, Chenwei Duan, Jing He, Siwei Zhang, Huanhuan Xie, Huining Li, Dawei Yuan, Fengmin Zhang, Hongxue Meng, Lanlan Wei
BACKGROUND/AIMS: Human papillomavirus (HPV) is an etiological risk factor for a subset of head and neck squamous cell carcinomas. HPV has been proven to be a powerful prognostic biomarker for oropharyngeal cancer, but its role in the larynx has not been explored in depth. Here, we sought to evaluate the prevalence and genotype distribution of HPV in patients with laryngeal squamous cell carcinoma (LSCC) in northeast China. METHODS: HPV DNA in specimens from 211 patients diagnosed with LSCC was analyzed by the polymerase chain reaction and in situ hybridization, and p16 overexpression was evaluated by immunohistochemistry...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30132891/prognostic-value-of-18-f-fdg-pet-ct-parameters-in-patients-who-undergo-salvage-treatments-for-recurrent-squamous-cell-carcinoma-of-the-larynx-and-hypopharynx
#17
Jae Ryung Lee, Turki M Almuhaimid, Jong-Lyel Roh, Jungsu S Oh, Soo-Jong Kim, Jae Seung Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Recurrent laryngeal/hypopharyngeal squamous cell carcinoma (LHSCC) is commonly associated with poor survival outcomes. We evaluated the prognostic role of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) parameters quantitatively measured in patients who underwent salvage treatments for recurrent LHSCC. METHODS: This study involved 100 consecutive LHSCC patients who underwent 18 F-FDG PET/CT for recurrent staging and subsequent salvage treatments...
September 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30115475/induction-chemotherapy-with-carboplatin-nab-paclitaxel-and-cetuximab-for-at-least-n2b-nodal-status-or-surgically-unresectable-squamous-cell-carcinoma-of-the-head-and-neck
#18
Jared Weiss, Jill Gilbert, Allison Mary Deal, Mark Weissler, Chris Hilliard, Bhishamjit Chera, Barbara Murphy, Trevor Hackman, Jay Justin Liao, Juneko Grilley Olson, David Neil Hayes
BACKGROUND: Although induction studies of TPF in SCCHN have not improved outcomes compared to chemoradiotherapy alone, phase II studies of weekly carboplatin (CbP), paclitaxel and cetuximab (C225) have shown promising results. Nano-albumin-paclitaxel (nab-paclitaxel) based chemotherapy has demonstrated a higher response rate (RR) than solvent-based paclitaxel in squamous cell carcinoma of the lung with favorable toxicity. MATERIALS AND METHODS: Patients with treatment naïve SCCHN of any site with ≥N2b disease or that was unresectable by strict criteria were eligible...
September 2018: Oral Oncology
https://www.readbyqxmd.com/read/30101013/induction-chemotherapy-in-patients-with-resectable-laryngeal-cancer-a-meta-analysis
#19
Pei Gao, Liang Gong, Xuefeng Wang
Head and neck squamous cell carcinoma (SCC) ranks 6th among the most frequently diagnosed carcinomas globally. Laryngeal carcinoma is quite common, and 95% of the cases are SCCs. Since the introduction of larynx-preserving surgery, induction chemotherapy (IC) has played a substantial role. The aim of IC is to shrink or downstage primary laryngeal carcinomas, increasing the chances of complete surgical removal, particularly in cases with advanced but potentially resectable lesions. The aim of the present study was to investigate the value of IC in patients with resectable laryngeal cancer...
August 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30098765/impact-of-obesity-on-outcomes-for-patients-with-head-and-neck-cancer
#20
Daniel F Hicks, Richard Bakst, John Doucette, Benjamin H Kann, Brett Miles, Eric Genden, Krzysztof Misiukiewicz, Marshall Posner, Vishal Gupta
OBJECTIVES: The prognostic role of obesity in head and neck squamous cell carcinoma (HNSCC) is not well defined. This study aims to determine its effect on disease-specific outcomes such as recurrence-free survival (RFS), locoregional recurrence-free survival (LRRFS), and distant metastasis-free survival (DMFS) in addition to overall survival (OS). METHODS: For patients with newly diagnosed HNSCC undergoing radiation therapy (RT) at a single institution, body mass index (BMI) at diagnosis was categorized as normal (18...
August 2018: Oral Oncology
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