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Head and neck neoplasms

V De Giorgi, L Salvati, A Barchielli, A Caldarella, A Gori, F Scarfì, I Savarese, N Pimpinelli, C Urso, D Massi
BACKGROUND: Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs) over the years. OBJECTIVE: The aim of our study was to evaluate incidence and survival of CACsand investigate their association with other skin neoplasms. METHODS: Population based study. Data on incident cases of CACs were obtained from the Tuscany Cancer Registry (TCR) between 1985 and 2010. In order to determine if the occurence of squamous cell carcinoma (SCC) among patients with CAC is higher or lower than expected in the general population, standardized incidence ratio (SIR) was calculated...
October 16, 2018: British Journal of Dermatology
Berhan Pirimoglu, Mecit Kantarci
Schwannoma is usually an uncommon benign encapsulated slow-growing neural tumor that originates from Schwann cells of peripheral, cranial, and autonomic nerves. It constitutes 1% to 8% of all head and neck neoplasms. Extracranial schwannoma are very rarely seen originating from the infraorbital nerve. Most of the schwannomas are usually solitary and not associated with NF1. The typical presentation is a slow-growing soft-tissue mass. Treatment of schwannoma is surgical resection.
October 12, 2018: Journal of Craniofacial Surgery
Ioannis Gkouveris, Nikolaos G Nikitakis, Jaya Asservatham, Kalu U E Ogbureke
The expression of proinflammatory cytokines in various malignant neoplasms is widely considered to represent the host immune response to tumor development. The role of interferon (IFN)γ in head and neck squamous cell carcinoma, and its association with endoplasmic reticulum (ER) stress pathways, remains a subject of ongoing investigation. Dentin sialophosphoprotein (DSPP), which is a member of the small integrin‑binding N‑linked glycoproteins family, has been implicated in malignant transformation and invasion of oral squamous cell carcinoma (OSCC)...
October 10, 2018: International Journal of Oncology
Tatiana M Villatoro, Stacey K Mardekian
Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of β -catenin, similar to other tumors that show this type of metaplasia, but the underlying mechanism responsible for this finding is not completely understood. We present two cases of low-grade non-ITAC with squamoid morules coexpressing CDX2 and nuclear β -catenin by immunohistochemistry, both of which were found to harbor a mutation in CTNNB1 , the gene encoding β -catenin...
2018: Case Reports in Pathology
Piyapan Prueksapanich, Thanawat Luangsukrerk, Rapat Pittayanon, Anapat Sanpavat, Rungsun Rerknimitr
Background/Aims: This study aimed to evaluate the diagnostic accuracy of dual-focus narrow-band imaging (dNBI) and Lugol'schromoendoscopy (LCE) combined with probe-based confocal laser endomicroscopy (pCLE) to screen for esophageal squamous cell neoplasms (ESCNs) in patients with a history of head and neck cancer. Methods: From March to August 2016, dNBI was performed. Next, LCE was performed, followed by pCLE and biopsy. Histology has historically been the gold standard to diagnose ESCN...
October 5, 2018: Clinical Endoscopy
Craig S Derkay, Andrew E Bluher
PURPOSE OF REVIEW: Recurrent respiratory papillomatosis (RRP) is the most common as well as the costliest benign airway neoplasm in the United States [Ivancic et al. (2018). Laryngoscope Investig Otolaryngol 3:22; Derkay (1995). Arch Otolaryngol Head Neck Surg 121:1386]. In addition, it is potentially deadly, with risk of airway obstruction as well as a 3-7% risk of malignant conversion [Schraff et al. (2004). Arch Otolaryngol Head Neck Surg 130:1039]. This review highlights exciting advancements over the past 1-2 years in scientific understanding of the pathophysiology, epidemiology, natural history, prevention, and treatment of this difficult disease...
October 8, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
Kanika Singh, Mukta Pujani, Varsha Chauhan, Charu Agarwal, Shruti Dhingra
Papillary thyroid carcinoma (PTC) arising within follicular adenoma is a rare histological subset of papillary carcinoma. A 24-year-old female (euthyroid and asymptomatic) presented with a solitary mass in the right lobe of thyroid for 2 years. Fine-needle aspiration cytology (FNAC) suggested features of hyperplasia of thyroid. Hemithyroidectomy was performed. Histopathological examination revealed two distinct areas and was reported as encapsulated variant of papillary carcinoma along with follicular adenoma...
September 2018: Indian Journal of Surgical Oncology
Lisa M Rooper, Vickie Y Jo, Cristina R Antonescu, Vania Nose, William H Westra, Raja R Seethala, Justin A Bishop
Adamantinoma-like Ewing sarcoma (ALES) is a rare tumor that demonstrates the EWSR1-FLI1 translocation characteristic of Ewing sarcoma despite overt epithelial differentiation including diffuse expression of cytokeratins and p40. Most cases of ALES described to date have occurred in the head and neck where they can mimic a wide range of small round blue cell tumors. Because distinguishing ALES from basaloid salivary gland carcinomas can be particularly difficult, we analyzed a series of 10 ALESs that occurred in the salivary glands with the aim of identifying features that allow for better recognition of this entity...
October 3, 2018: American Journal of Surgical Pathology
Congcong Liu, Lianqi Yan, Qing Liu, Jing Li, Hongtao Jin, Jingcheng Wang, Youwen Deng
RATIONALE: Microcystic/reticular schwannoma (MRS) is a rare histological variant of schwannoma which was initially described in 2008 with a predilection for the visceral organs. This distinct tumor had been reported to mainly affect gastrointestinal tract, subcutaneous and soft tissue, various glands and head and neck region. However, MRS involving spine is extremely rare. PATIENT CONCERNS: The authors report the first case of MRS occurring in the lumbar (L) spinal canal of a 40-year-old male who presented with continuous pain and numbness in both feet for 2...
September 2018: Medicine (Baltimore)
K Devaraja, Prem Sagar, Chirom Amit Singh, Rajeev Kumar
Rhinosporidiosis is a communicable disease prevalent in tropical countries that affects one or more mucocutaneous sites such as the nasal cavity, pharynx, skin, bronchus, genitals, and bone, in isolation or together. We report a case of multicentric rhinosporidiosis involving the nasal cavity, oropharynx, larynx, and cheek skin without disseminated disease outside the head and neck. Although the appearance of mucocutaneous lesions in our patient was similar to that of papilloma or neoplasm, the distinct clinicopathologic characteristics of the rhinosporidiosis guided us in managing the case successfully...
September 2018: Ear, Nose, & Throat Journal
Pavandeep Gill, Marie Abi Daoud
Cellular neurothekeoma is a benign cutaneous neoplasm that typically occurs on the head, neck, and upper body of young adults with a slight female predominance. It is a rare lesion to diagnose and multiple neurothekeomas in one patient is an even more uncommon finding. We present a case of multiple neurothekeomas in a middle-aged woman with lower extremity involvement and summarize the current literature on multiple neurothekeoma patients. A 46-year-old female presented with nearly one dozen skin-coloured papules on the head, upper limb, and lower limb...
October 1, 2018: Journal of Cutaneous Pathology
A Portincasa, L Cecchino, E M C Trecca, F Lembo, L Annacontini, F Ciancio, F Corsi, M Cassano, D Parisi
INTRODUCTION: The authors present a "four-step" integrated surgical protocol to treat a rare case of multiple giant eccrine spiradenoma (ES) of the head and neck in a young patient. PRESENTATION OF CASE: An 18-year-old female patient presented with multiple swellings in the head and neck regions. The patient had a severe psychological trauma with a negative impact on her social life. Physical examination revealed multiple papulo-nodular swellings measuring between 5 cm × 8 cm and up to 10 cm × 20 cm in size with cerebriform aspect and soft consistency...
September 12, 2018: International Journal of Surgery Case Reports
Hunter John Piegols, Marilia Takada, Maciej Parys, Thomas Dexheimer, Vilma Yuzbasiyan-Gurkan
Feline oral squamous cell carcinomas (FOSCC) are highly aggressive neoplasms with short survival times despite multimodal treatment. FOSCC are similar to squamous cell carcinomas of the head and neck (SCCHN) in humans, which also present therapeutic challenges. The current study was undertaken to identify novel chemotherapeutics using FOSCC cell lines. A high throughput drug screen using 1,952 drugs was performed to identify chemotherapeutics for further investigation. Two of the drugs identified in the drug screen, actinomycin D and methotrexate, and two drugs with similar molecular targets to drugs found to be efficacious in the screening, dinaciclib and flavopiridol, were selected for further investigation...
September 4, 2018: Oncotarget
Lingqiong Zhao, Jie Liu, Shu Chen, Chun Fang, Xianquan Zhang, Zhibin Luo
Purpose: NANOG is a tumor marker and indicates poor prognosis in various neoplasms; however, the evidence is controversial. This meta-analysis investigated the association of NANOG expression and clinicopathological features, and it impact on survival of patients with malignant tumors. Methods: Studies published through May 31, 2018 were retrieved from PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure. Two researchers independently screened the content and quality of studies and extracted data...
2018: OncoTargets and Therapy
Sylvia L Asa, Shereen Ezzat, Ozgur Mete
Paragangliomas are neuroendocrine neoplasms, derived from paraganglia of the sympathetic and parasympathetic nervous systems. They are most commonly identified in the head and neck, being most frequent in the carotid body, followed by jugulotympanic paraganglia, vagal nerve and ganglion nodosum, as well as laryngeal paraganglia. Abdominal sites include the well-known urinary bladder tumors that originate in the Organ of Zuckerkandl. However, other unusual sites of origin include peri-adrenal, para-aortic, inter-aortocaval, and paracaval retroperitoneal sites, as well as tumors in organs where they may not be expected in the differential diagnosis of neuroendocrine neoplasms, such as thyroid, parathyroid, pituitary, gut, pancreas, liver, mesentery, lung, heart and mediastinum...
September 13, 2018: Journal of Clinical Medicine
Ayush Naik, Virendra Bhandari, R Y Saadvik, K L Gupta, Mehlam Kausar, Manika Batra
Background: Advancement in diagnostic and therapeutic modalities lead to increased cancer survivors who have 20% higher risk of developing second primary malignancy (SPM). Aim: To look for the incidence, epidemiological factors, treatment-related factors, and common risk factors responsible for the development of the SPM in Malwa region. Materials and Methods: Records of 7709 patients who visited the Department of Oncology between May 2008 and August 2015 were analyzed and looked for the presence of SPM based on Warren and Gates criteria for head and neck and International Agency for Research on Cancer definition for other sites...
July 2018: Journal of Cancer Research and Therapeutics
Anna Rzepakowska, Ewa Osuch-Wójcikiewicz, Zuzanna Krupa, Aneta Durmaj, Kazimierz Niemczyk
INTRODUCTION: Parapharyngeal space (PPS) is the anatomical area lateral to the upper pharynx and clinically important due to PPS tumors. They account for less than 1% of head and neck neoplasms. Both benign and malignant neoplasms may arise there and typical for this localization is diversity of histological origin. Complete surgical excision is still the basis of treatment. AIM OF THE STUDY: Evaluation of the results of surgical treatment of PPS tumors in the Department of Otolaryngology at the Medical University over the period 2015-2017...
May 16, 2018: Otolaryngologia Polska
Carla Bento Nelem-Colturato, Patrícia Maluf Cury, Thiago Machado Pereira, Isabelle Silva Cosso, Kellin Pivato, Luiz Evaristo Ricci Volpato, Alvaro Henrique Borges
Background: Field cancerization is a phenomenon in which prolonged exposure to carcinogens induces changes throughout the epithelium leaving the field ready for the appearance of premalignant or malignant lesions. These alterations can promote the development of multiple carcinomas and explain the appearance of recurrences and second primary tumors. The objective of this study was to report the case of a patient who developed six oral cavity tumors in five years of treatment and, also, demonstrate the immunohistochemical changes for p53 and Ki-67, routinely used to assess dysplasic regions...
2018: Case Reports in Pathology
Amy B Farkas, Laura K House, Majid Khan, Ali G Saad, Ellen Parker, David Joyner
Liposarcoma of the larynx is a rare entity, typically well differentiated with a good prognosis. We present a patient who presented to ENT clinic with a 3-month history of hoarseness. Contrast-enhanced computed tomography of the neck demonstrated a 2.5-cm mass of the true vocal cord, which biopsy demonstrated to be dedifferentiated liposarcoma of the larynx. The patient went on to total laryngectomy with planned adjuvant radiation therapy. The presentation and imaging findings of laryngeal liposarcoma are nonspecific, but this neoplasm should be considered in the differential of masses in the head and neck...
June 2018: Radiology Case Reports
Tabita Joy, Jagdish Vishnu Tupkari, Amrut V Hanchate, Pooja Siwach
Rhabdomyosarcoma is a malignant neoplasm of mesenchymal cells, showing varying degrees of striated muscle cell differentiation. It predominantly occurs in children while rarely found in adults and involvement of the oral cavity accounts for only 10%-12% of all head-and-neck cases. Herewith, we present a rare case of spindle cell rhabdomyosarcoma in a 52-year old male, involving the mandibular gingiva, and describe the clinical, radiological, histopathological and immunohistochemical findings.
May 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
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