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Head and neck neoplasms

Mohammed Bu Bshait, Hassan Alyami, Emad Al-Osail, Haytham Al Arfaj
INTRODUCTION: Hypoglossal nerve palsy (HNP) is a rare complication of airway management. Multiple factors have been postulated to contribute to its occurrence. Herein, we present a case of ipsilateral HNP following left hemithyroidectomy. CASE PRESENTATION: A 47-year-old women presented complaining of left thyroid swelling for 1 year with no symptoms of compression or hormonal impairment. Ultrasound of the neck showed a 3 × 2 cm nodule in the left thyroid lobe without lymphadenopathy...
August 11, 2018: International Journal of Surgery Case Reports
Sara Massironi, Stefano Partelli, Maria C Petrone, Alessandra Zilli, Dario Conte, Massimo Falconi, Paolo G Arcidiacono
BACKGROUND/OBJECTIVES: The pancreatic localization of serotonin-staining neuroendocrine neoplasms is extremely rare. This is a retrospective study aimed at analyzing the endoscopic ultrasound appearance of pancreatic serotoninoma. METHODS: Between 2010 and 2016, all consecutive patients with histologically proven pancreatic serotoninoma who had undergone endoscopic ultrasound were enrolled. RESULTS: Eight patients (six F, median age 68.5 years) had a diagnosis of pancreatic serotoninoma and underwent endoscopic ultrasound examinations...
August 11, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Adeyi A Adoga, Daniel D Kokong, Nuhu D Ma'an, Olugbenga A Silas, Ayuba M Dauda, John P Yaro, Joyce G Mugu, Chukwunonso J Mgbachi, Caleb J Yabak
Introduction: This study aims to evaluate the epidemiology, treatment, and factors that determine the outcomes of head and neck cancers (HNC). Patients and Methods: Retrospective analytical review of HNC managed at the Jos University Teaching Hospital between May 2007 and April 2017 using the International Classification of Diseases version 10. Results: Of 487 head and neck neoplasms, 129 (26.5%) were malignant and 122 health records met the criteria for analysis consisting of 83 (68...
July 2018: South Asian Journal of Cancer
Yu-Ting Chen, Jian-Ni Yao, Yu-Tao Qin, Kai Hu, Fang Wu, Ye-Ying Fang
MicroRNAs (miRNAs) are confirmed to be tumor promoters or suppressors in multiple squamous cell carcinomas (SCCs). miR-99a-5p has been demonstrated to be downregulated in cancerous tissues, but its functional role in head and neck SCC (HNSCC) and its mechanism of action have not been fully elucidated. Here, we studied the expression of miR-99a-5p in HNSCC and performed a clinical value assessment and then extracted mature expression data from The Cancer Genome Atlas (TCGA) and microarrays from Gene Expression Omnibus (GEO)...
August 2018: FEBS Open Bio
Jing Yang, Carmen Sarita-Reyes, David Kindelberger, Qing Zhao
Background: Malignant biphasic tumor also known as carcinosarcoma is an uncommon neoplasm that is composed of both malignant epithelial and mesenchymal components. Most reported cases of carcinosarcoma affect the female genital tract; however, other sites including head and neck, lung, and breast have been described. Carcinosarcoma of the thyroid is an extremely rare and aggressive malignancy with an ominous clinical course similar to anaplastic carcinoma. Case presentation: We report a case of a 45-year-old female who was found to have a biphasic thyroid carcinosarcoma...
2018: Thyroid Research
Raissa Borges Curtarelli, Jussara Maria Gonçalves, Luciane Geanini Pena Dos Santos, Maria Gorete Savi, Jacques Eduardo Nör, Luis André Mendonça Mezzomo, Mabel Mariela Rodríguez Cordeiro
Malignant neoplasms may be composed of several cell groups, including cancer stem cells (CSC). These cells have been related with the capacity of metastasis, relapse and resistance to multiple drugs during chemotherapy. This study aims to identify CSC biomarkers and their expression pattern in human head and neck carcinomas. This study was conducted following the PRISMA checklist. The search for articles was carried out in five databases (PubMed, Scopus, Web of Science, Lilacs and Scielo). The articles found were selected in two phases: 1) reading the titles and / or abstract and 2) reading the full text...
August 3, 2018: Stem Cell Reviews
Dinesh Kumar, Anita Vallacha
Dermatofibrosarcoma protuberans (DFSP) is a rare malignant neoplasm of skin, subcutaneous tissue and dermis, with more potential of local infiltration, appears most frequently on the trunk, followed by extremities, head, neck, and extremely rare in breast. It often occurs in young adults and middle-aged adults. The standard of treatment for this disease is local surgical excision with 2-3 cm wide margins. We present a case of 49-year lady with right breast well-circumscribed, firm, tender, mobile, and progressive lump that was benign-looking, on physical examination as well as on mammography...
August 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Raffaele Giusti, Paolo Bossi, Marco Mazzotta, Marco Filetti, Daniela Iacono, Paolo Marchetti
Background: Head and neck (H&N) cancers account for about 5% of all malignant tumours. Pain is one of the most feared consequences of H&N neoplasms and is experienced by up to 80% of patients and worsens their quality of life inhibiting speaking, eating, drinking or swallowing. Nevertheless, pain is still often underestimated and undertreated. Objectives: The role of opioids in cancer pain has been well established but evidences about the role and the relative effectiveness of opioids such as fentanyl in the context of H&N cancer pain remains unclear...
August 2018: British Journal of Pain
Celso Muller Bandeira, Adriana Ávila de Almeida, Celina Faig Lima Carta, Alaor Aparecido Almeida, Fellipe Augusto Tocchini de Figueiredo, Valeria Cristina Sandrim, Antonio José Gonçalves, Janete Dias Almeida
Heavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group)...
July 28, 2018: Environmental Science and Pollution Research International
Meriem Mokhtech, Catherine E Mercado, James W Lynch, Nancy P Mendenhall, William M Mendenhall
BACKGROUND: Classic Hodgkin lymphoma is a malignant neoplasm of the lymphatic system that commonly presents with cervical and mediastinal lymphadenopathy. Primary extranodal disease of the head and neck is rare, with only a few cases reported in the literature. In this case report, we describe the presentation, treatment, and clinical outcome of a patient who presented with extranodal Hodgkin lymphoma of the maxillary sinus. METHODS: We report a case of extranodal classic Hodgkin lymphoma of the maxillary sinus treated with 2 cycles of chemotherapy and consolidative radiotherapy (RT)...
July 26, 2018: Head & Neck
Kim Menard, Brian K Flesner, Anastasia Glahn, Bonnie Boudreaux, Jeffrey N Bryan
5-Fluorouracil (5-FU) is used in combination chemotherapy protocols for human head and neck cancer and other epithelial neoplasms. However, a paucity of literature describing use of this drug in veterinary oncology exists, likely due to previous reports of fatal neurotoxicity in both dogs and cats, mainly due to ingestion of human creams. The primary aim of this retrospective study was to report the safety of concurrent 5-FU and carboplatin in canine carcinomas. Secondarily, we aimed to look at the efficacy of the combination using overall response rate in treated dogs...
July 24, 2018: Veterinary and Comparative Oncology
Akshay Gopinathan Nair, Indumati Gopinathan, Rima Singh, Rima S Pathak
Adenoid cystic carcinoma (ACC) is an uncommon malignant neoplasm composed of basaloid epithelial and myoepithelial cells. The palate is the most commonly involved intraoral site for ACC. Here, we document the case of an advanced ACC arising from the hard palate that presented with right-sided sixth nerve palsy in a 75-year-old male with no other systemic illnesses. ACC of the head and neck involving the cavernous sinus and presenting as isolated sixth nerve palsy is exceedingly rare. In the absence of vasculopathic or ischemic risk factors, regardless of the age of the patient; neuroimaging should be performed in cases of isolated nontraumatic sixth nerve palsy...
August 2018: Indian Journal of Ophthalmology
Km Nitschinsk, A Idris, Na McMillan
Translational cancer research has benefitted significantly from the generation of preclinical models that recapitulate the native tumour environment. While conventional cell models have contributed substantially to the current understanding of cancer biology and therapeutic development, a missing link between cell culture and their clinical applications is evident. Patient derived xenograft (PDX) models represent this missing link as they enable the examination of patient tumour tissue in a native environment without significantly affecting the cellular complexity, genomics, and stromal architecture of the neoplasms...
July 18, 2018: Cancer Letters
E Innocent, A N Manasseh, E V Badoe, Y Daniel, K B Vandi, A Olanrewaju, E U Graham
BACKGROUND: The designation Rabdomyosarcoma (RMS) is used to describe the malignant mesenchymal neoplasm that exhibits varying degree of skeletal muscle differentiation. RMS is the commonest malignancy of soft tissues afflicting children and adolescent up until age 20. It constitutes 5-10% of pediatric malignancies, and 7-9.5% of pediatric soft tissue sarcomas. The site of origin of RMS can be one of three possibilities: myogenous; extramyogenous; and ectopic (heterotopia). This was a retrospective study of consecutive cases of RMS seen at the Histopathology Department of the Jos University Teaching Hospital, Jos, between January 2007 and December 2016...
May 2018: West African Journal of Medicine
Eric Adjei Boakye, Paula Buchanan, Leslie Hinyard, Nosayaba Osazuwa-Peters, Mario Schootman, Jay F Piccirillo
Importance: Second primary malignant neoplasms (SPMNs) are the leading cause of death in survivors of head and neck squamous cell carcinoma (HNSCC). Recently, human papillomavirus (HPV) has emerged as a risk factor for oropharyngeal squamous cell carcinoma and has different prognosis from classic tobacco/alcohol-associated HNSCC. This suggests that there also may be different risks and burden of SPMNs among patients who's HNSCC were from HPV or tobacco and/or alcohol. Objective: To assess SPMN risks and burden in a large US cohort of patients with a first potentially HPV-associated HNSCC vs non-HPV-associated HNSCC...
July 19, 2018: JAMA Otolaryngology—Head & Neck Surgery
Shahd M Hafiz, Eman S Bablghaith, Amal J Alsaedi, Mohammad H Shaheen
Giant-cell tumor of soft tissue (GCT-ST) is a rare neoplasm that was first described in 1972. Due to its histological and immune-histochemical similarities with GCT of bones, GCT-ST is thought to be its counterpart. This review article aims to recognize the characteristics of this rare tumor along with a favorable way to diagnose and treat. We reviewed 12 cases of GCT-ST in the head and neck. This tumor involves both sexes at any age. Histopathology in many cases revealed the presence of mononuclear cells and spindle cells...
July 2018: International Journal of Health Sciences
Rizwan Ishtiaq, Kalika Sarma, Ike Uzoaru, Waseem Khaliq
Extramedullary plasmacytoma (EP) is a rare neoplasm characterized by monoclonal proliferation of plasma cells without features of multiple myeloma. EP constitutes 3% of all plasma cell tumors. Most of the cases of EP occur in the head and neck regions, especially in the aerodigestive tract. We present a case of recurrent epistaxis for 6 months and extensive workup revealed EP of the right nasal cavity. Primary care physicians and otolaryngologists should be aware of this very rare but a plausible cause of epistaxis and keep EP in the differential diagnosis of recurrent epistaxis...
July 25, 2018: Postgraduate Medicine
Jian-Qing Qiu, Yu-Qiu Zhou, Ting-Yan Yue, Jiao Pei, Chun-Yan Shui, Xiao-Song Li, Tao Zhang
OBJECTIVE: To compare the effect of different approaches of missing data replacement on the regression coefficient estimates r of "length of stay" on "hospital expenditure". METHODS: Data were extracted from the medical records of patients with head and neck neoplasms who were admitted to Sichuan Cancer Hospital. R 3.4.1 was used for generating and processing simulated datasets. Various scenarios were established by setting up different proportions of missing data and missing mechanisms using Monte Carlo method...
May 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Theodora Tzanavari, Jason Tasoulas, Chrysoula Vakaki, Chrysovalantou Mihailidou, Gerasimos Tsourouflis, Stamatios Theocharis
Adipokines constitute a family of protein factors secreted by white adipose tissue (WAT), that regulate the functions of WAT and other sites. Leptin, adiponectin, resistin, are the main adipokines present in serum and saliva, targeting several tissues and organs, including vessels, muscles, liver and pancreas. Besides body mass regulation, adipokines affect glucose homeostasis, inflammation, angiogenesis, cell proliferation and apoptosis, and other crucial cell procedures. Their involvement in tumor formation and growth is well established and deregulation of adipokine and adipokine receptors' expression is observed in several malignancies including those located in the head and neck region...
July 13, 2018: Current Medicinal Chemistry
Nisha Raghani, Manish J Raghani, Sruthi Rao, Santhosh Rao
Hemangiopericytomas (HPCs)/Solitary fibrous tumor are rare neoplasms of vascular origin that occur in head-and-neck region. These tumors arise from capillary pericytes and are difficult to distinguish from other tumors of vascular origin. HPC, initially described by Stout and Murray in 1942, usually occur in the fifth decade of life and account for 3%-5% of all soft-tissue sarcomas and 1% of all vascular tumors. The tumors usually occur in limbs, pelvis, or head-and-neck region; 15%-30% of all HPCs occur in head and neck...
January 2018: Annals of Maxillofacial Surgery
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