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Head and neck neoplasms

Alexander T Kessler, Alok A Bhatt
The salivary glands are small structures in the head and neck, but can give rise to a wide variety of benign and malignant pathology. When this occurs, patients may present with palpable swelling, although it is quite common that they are asymptomatic and a salivary gland mass was discovered as an incidental finding on imaging performed for another reason. It is, therefore, critical that radiologists pay careful attention to the salivary glands and have working knowledge of the key differentiating features of the most common neoplastic and nonneoplastic etiologies of salivary gland masses...
2018: Journal of Clinical Imaging Science
Massimo Ralli, Massimo Fusconi, Irene Claudia Visconti, Salvatore Martellucci, Marco de Vincentiis, Antonio Greco
'Juvenile' nasopharyngeal angiofibroma, which accounts for <1% of all head and neck neoplasms, occurs predominantly in males between 10 and 18 years of age. The small number of patients older than 30 years confirms that presentation after this age is exceptional. Only rare cases of nasopharyngeal angiofibroma in female patients have been documented to date, and some authors believe that sex chromosome studies are indicated in such cases. The pathogenesis of nasopharyngeal angiofibroma remains unknown, but it has been hypothesized that it is a testosterone-dependent tumor...
December 2018: Molecular and Clinical Oncology
J Clarke, S Medford, S Islam, C Ramsingh, M Christopher
BACKGROUND: Lymphomas are malignant neoplasms of the lymphocyte cell lines affecting the lymph nodes, spleen and other nonhemopoietic tissues. Of the extranodal lymphomas found in the head and neck region, 3-5% of malignant lymphomas arise in the oral and paraoral region, mainly from Waldeyer's ring. The involvement of the base of the tongue is extremely rare. SUMMARISED CASE: Case 1: 64 year old female who presented initially with an enlarged occipital lymph node which gradually became generalized cervical lymphadenopathy with initial histology confirmed reactive lymphoid hyperplasia...
November 30, 2018: International Journal of Surgery Case Reports
Juliana de Brito Rangel, Luiz Claudio Santos Thuler, Jorge Francisco da Cunha Pinto
OBJECTIVE: Several studies have shown a higher prevalence of hepatitis C virus (HCV) infection among patients with head and neck cancer (HNC) compared to the general population. In Brazil, the prevalence of HCV infection is considered low (1.38%). The aim of this study was to determine HCV prevalence and how this can modify outcomes of patients with HNC. STUDY DESIGN: Retrospective cohort. METHODS: Patients with a diagnosis of malignant neoplasm in the head and neck (HN) region and who had serology performed for HCV were included...
December 2018: Oral Oncology
Matteo Brucoli, Giovanni Borello, Paolo Boffano, Arnaldo Benech
Tuberculosis (TB) continues to be a major health problem for the developing world and a a rise in the number of cases has been noted in the western hemisphere too. TB can affect most organs in the head and neck region, such as the lymph nodes, larynx, middle ear, oral cavity and pharynx. In particular, as for cervical tuberculosis lymphadenopathy, a predominant involvement of the posterior triangle, supraclavicular, and internal jugular group of nodes bilaterally can be observed. As the early manifestation of Head and Neck TB is often similar to neoplasms, clinical consideration usually occurs only after an ineffective anti-inflammatory treatment, fine-needle aspiration, or biopsy / resection...
December 1, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
Ezra E W Cohen, Denis Soulières, Christophe Le Tourneau, José Dinis, Lisa Licitra, Myung-Ju Ahn, Ainara Soria, Jean-Pascal Machiels, Nicolas Mach, Ranee Mehra, Barbara Burtness, Pingye Zhang, Jonathan Cheng, Ramona F Swaby, Kevin J Harrington
BACKGROUND: There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour activity and manageable toxicity in early-phase trials. We aimed to compare the efficacy and safety of pembrolizumab versus standard-of-care therapy for the treatment of head-and-neck squamous cell carcinoma. METHODS: We did a randomised, open-label, phase 3 study at 97 medical centres in 20 countries...
November 30, 2018: Lancet
Romesh P Nalliah, Deepti Shroff, Kyle Stein, Sangeetha Chandrasekaran, Sankeerth Rampa, Veerajalandhar Allareddy, Veerasathpurush Allareddy
PURPOSE: In the United States, 2.1 million people develop substance abuse disorders that are associated with prescribed opioids. The objective of the present study was to identify the factors associated with opioid abuse and dependence (OAD) in those hospitalized for head and neck cancer (HNC). Although measures are being implementing to reduce opioid prescribing, the use of these drugs in individuals with HNC can be valuable. However, little is known about OAD among this cohort of individuals...
December 2018: Journal of Oral and Maxillofacial Surgery
Alessandro Franchi, Justin A Bishop, Hedley Coleman, Uta Flucke, Lisa F Licitra, José Luis Llorente Pendás, Edward B Stelow, Mary Toner, Ilan Weinreb, Bruce M Wenig, Lester D R Thompson
The International Collaboration on Cancer Reporting was established to internationally unify and standardize the pathologic reporting of cancers based on collected evidence, as well as to allow systematic multi-institutional intercountry data collection to guide cancer care in the future. This data set has been developed by the collaborative efforts of an international multidisciplinary panel of experts involved in the care of patients with carcinomas of the nasal cavity and paranasal sinuses (sinonasal tract)...
November 30, 2018: Archives of Pathology & Laboratory Medicine
Ruta Gupta, Ann Sandison, Bruce M Wenig, Lester D R Thompson
The International Collaboration on Cancer Reporting (ICCR) was established to internationally unify and standardize the pathologic reporting of cancers based on collected evidence, as well as to allow systematic multi-institutional intercountry data collection to guide cancer care in the future. Such collaborative efforts are particularly essential for developing an evidence base for rare neoplasms, or those with marked geographic variation in incidence, such as the tumors of the ear and the temporal bone. The ear and the temporal bone, including the external auditory canal and the middle and inner ear, with the closely associated facial nerve, internal carotid artery, and internal jugular vein, is one of the most complex anatomic structures in the head and neck...
November 30, 2018: Archives of Pathology & Laboratory Medicine
Shouzhou Liu, Wenchao Duan
Laryngeal squamous cell carcinoma (LSCC) is a very common neoplasm of the head and neck in the world. Long noncoding RNAs play key roles in cell infiltration, fate, apoptosis, and invasion. However, the functional role and expression of LINC00339 remains unclear in LSCC. In this study, we showed that the expression level of LINC00339 was upregulated in LSCC tissues and cell lines. LINC00339 silencing suppressed the proliferation, invasion, and epithelial-mesenchymal transition (EMT) progression of LSCC cells...
November 28, 2018: Journal of Cellular Biochemistry
John Oommen, Hafiz Mohammed, Shanker Ayyappan Kutty, Abraham Mammen, Kader Kalathingal, Chandrabose Vellani Thamunni, Anand Sivadasan, Santhy Nair
Teratomas are rare congenital neoplasms. Head and neck locations of the tumor are uncommon with combined intracranial and extracranial extensions being even more rare. The authors present a case of teratoma involving the temporal, buccal, maxillary, orbital and extending to the intracranial regions, which was successfully managed by surgical resection.
November 22, 2018: Journal of Craniofacial Surgery
Peter P Luk, Christina I Selinger, Wendy A Cooper, Annabelle Mahar, Carsten E Palme, Sandra A O'Toole, Jonathan R Clark, Ruta Gupta
Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms...
November 22, 2018: Head and Neck Pathology
Dong Hwi Kim, Ji Sung Lee, Jong Weon Shin, Jean A Kim, Young Joon Jun
Kaposiform hemangioendothelioma (KHE) is a very rare, locally aggressive vascular neoplasm. It occurs mostly in children and is rarely observed in adults. It typically originates on the skin, later affecting the deep soft tissue of the extremities, head or neck, and retroperitoneum by infiltrative growth. It is locally aggressive, does not regress spontaneously, and tends to metastasize locally as well as to the regional lymph nodes. In this article, we report a case of adult-onset KHE with neurofibromatosis type 1...
November 2018: Archives of Plastic Surgery
Debasis Gochhait, Ramkumar Govindarajalou, Rakhee Kar, Vidhyalakshmi Rangarajan, Priyadarshini Dehuri, Biswajit Dubashi
Plasma cell neoplasms may have a spectrum of clinical presentation ranging from asymptomatic proliferation to single/multiple mass lesions in medullary/ extramedullary sites. Extramedullary plasmacytoma (EMP) is a rare tumor of the soft tissue without theinvolvement of bone marrow which most commonly affects the head and neck region and may precede multiple myeloma (MM) (1). Thyroid can rarely be a site for EMP or may be infiltrated by systemic multiple myeloma. These patients are predominantly males and are usually well beyond middle age...
November 21, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
C Y Shui, C Li, R H Sun, Y Q Zhou
Sinonasal neoplasms are common tumors in the head and neck.The types of tumor pathological tissues are complex and diverse, and the incidence of malignant tumors is relatively low.The malignant tumor of paranasal sinuses is occult, and most of them are locally advanced.Although surgery is the main treatment for such diseases, the specific treatment plan is still controversial.This article reviews the treatment of sinonasal malignancy.
November 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Zvonimir L Milas, Thomas D Shellenberger
No abstract text is available yet for this article.
February 2019: Oral and Maxillofacial Surgery Clinics of North America
Aruna Nambirajan, Moanaro Longchar, Karan Madan, Saumya Ranjan Mallick, Aanchal Kakkar, Sandeep Mathur, Deepali Jain
BACKGROUND: Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is the primary modality for mediastinal lymph node staging in lung carcinoma. We aimed to evaluate its utility in extra-pulmonary malignancies (EPM). METHODS: Database search of EBUS-TBNA aspirations (2013-2017) done in patients with known/suspected EPMs and mediastinal lymphadenopathy/masses was performed. All archived cytology/histology material was reviewed and categorized as positive, negative and unsatisfactory...
November 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Natasha D Dombrowski, Nikolaus E Wolter, Alexandria L Irace, Michael J Cunningham, Sara O Vargas, Antonio R Perez-Atayde, Caroline D Robson, Reza Rahbar
OBJECTIVE: Pleomorphic adenoma is the most common benign salivary gland neoplasm in children. Recurrence and malignant transformation are concerns necessitating proper treatment. The goal of this research was to discuss the presentation, evaluation, and management of pediatric pleomorphic adenoma of the head and neck. METHODS: Retrospective chart review of patients under 20 years of age treated for pleomorphic adenoma of the head and neck between 1998 and 2017. Data assessed included demographics, clinical presentation, imaging, treatment, complications, recurrence, and follow-up...
November 15, 2018: Laryngoscope
Andrea Ronchi, Iacopo Panarese, Gabriella Aquino, Antonio Gambardella, Franco Franco, Immacolata Cozzolino
Synovial sarcoma (SS) is a mesenchymal neoplasm usually affecting adolescents and young adults, with one third of cases occuring in the first two decades of life. SS is characterized by the specific balanced chromosomal translocation t(X;18)(p11;q11), resulting in the fusion of SYT gene on chromosome 18 with SSX1, SSX2 or SSX4 gene on chromosome X. SS predominantly arises in the soft tissue around large joints of the lower extremities. Other sites include head and neck, thorax, heart or pericardium, abdomen and pelvis...
November 12, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
I V Reshetov, N S Sukortseva, D S Svyatoslavov, A A Shevalgin, P A Nasilevskiy
The robotic technologies every day exert an increasingly greater influence on the surgical technique, with the well documented clinical applicability in reconstructive plastic surgery and oncology. At the Department of plastic surgery of I.M. Sechenov First Moscow state medical university, we have gained an extensive experience with the surgical treatment of the patients requiring the major oral robotic intervention. A novel application has recently been documented for the purpose of robotic surgical assistance to the patients presenting with oncological pathology including cancer of the oropharyngeal wall at the early stages of development (T1N0M0)...
2018: Vestnik Otorinolaringologii
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