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Roberto Corradini
Polyamide analogs of DNA, or peptide nucleic acid (PNA), were first proposed in 1991 by a group of chemists and biochemists in a memorable Science paper [1].[…].
August 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Santu Bera, Sudipta Mondal, Sigal Rencus-Lazar, Ehud Gazit
The unique physiochemical properties and multiscale organization of layered materials draw the attention of researchers across a wide range of scientific disciplines. Layered structures are commonly found in diverse biological systems where they fulfill various functions. A prominent example of layered biological materials is the organization of proteins and polypeptides into the archetypal aggregated amyloidal structures. While the organization of proteins into amyloid structures was initially associated with various degenerative disorders, it was later revealed that proteins not related to any disease could also form identical layered assemblies...
August 10, 2018: Accounts of Chemical Research
Francesca De Falco, Gennaro Gentile, Roberto Avolio, Maria Emanuela Errico, Emilia Di Pace, Veronica Ambrogi, Maurizio Avella, Mariacristina Cocca
Washing processes of synthetic clothes have been identified as the main source of microplastic pollution in marine ecosystems. Textile microfibres have been found in marine sediments and organisms, posing a real threat for the environment. The development of mitigation approaches is strongly needed to prevent the impact of microplastics. In this work, an innovative finishing treatment of polyamide fabrics is proposed to mitigate the microplastic impact, by preventing the damage of fabrics during washings. The treatment is based on the use of pectin, a natural polysaccharide present in the cell walls of plants...
October 15, 2018: Carbohydrate Polymers
Edgar Franco, Rosmery Dussán, Maribel Amú, Diana Navia
Polymeric nanofibers are widely studied in the textile industry since with them, it is possible to get a great variety of functionalities. In this paper, polyamide 6/66 (PA 6/66) solutions at different concentrations (12, 17, and 22% wt.) were made, to get nanofibers through the basic electrospinning process which were characterized by scanning electron microscope (SEM) and productivity. Afterwards, nanofiber bundles were produced using the electrospinning sol-gel process, which were characterized by SEM and tensile test...
August 8, 2018: Nanoscale Research Letters
Christine Devouge-Boyer, Sarah Mouda, Olivier Gueguen, Stéphane Marcotte
A method was developed for the determination of iodine in polyamide (PA). This method is needed as PA containing iodine (such as CuI/KX (X = I or Br) heat stabilizing agent), may represent a risk of corrosion for electronic parts in the automotive industry. The method involved a microwave assisted digestion method using nitric acid followed by inductively coupled plasma mass spectrometry (ICP-MS) analysis. A dilution in 0.5% NH3 was needed prior to ICP-MS analysis to suppress memory effect. The limit of quantification was estimated to be 0...
November 1, 2018: Talanta
Cheng Lv, Jie Yang, Rui Liu, Qun Lu, Yue Ding, Jiuliang Zhang, Jianling Deng
The adsorption and desorption characteristics of six different resins (NKA-9, XAD-2, AB-8, D3520, DM-130 and Polyamide) were investigated, in order to screen one resin compared favorably with XAD-2 resin for the purification of flavonoids from honey. The adsorption capacity was XAD-2 > AB-8 > DM-130 > D3520 > NKA-9 > Polyamide, and the desorption ratios of XAD-2, AB-8 and DM-130 had no significant differences, which was higher than those of D3520, NKA-9 and Polyamide. By analyzing kinetic adsorption using pseudo-first-order, pseudo-second-order and particle diffusion kinetics models combined with kinetic desorption, the adsorption and desorption behavior of AB-8 was similar to that of XAD-2, which was excellent than other four resins...
December 1, 2018: Food Chemistry
Anderson Abel Souza de Souza Machado, Chung Wai Lau, Jennifer Till, Werner Kloas, Anika Lehmann, Roland Becker, Matthias C Rillig
Soils are essential components of terrestrial ecosystems that experience strong pollution pressure. Microplastic contamination of soils is being increasingly documented, with potential consequences for soil biodiversity and function. Notwithstanding, data on effects of such contaminants on fundamental properties potentially impacting soil biota are lacking. The present study explores the potential of microplastics to disturb vital relationships between soil and water, as well as its consequences for soil structure and microbial function...
July 27, 2018: Environmental Science & Technology
Youdan Zheng, Rui Wang, Xiangyu Dong, Lixin Wu, Xu Zhang
The rapidly growing fields of aerospace, energy and electronic devices raise the demand for materials with ever-increasing mechanical properties, electrical and thermal conductivity. However, the combination of unusually high performance is difficult to attain. In this study, using pre-built three-dimensional (3D) closely packed interconnected multi-walled carbon nanotubes (MWNTs) networks as backbone for assembly of polymer matrix, a novel, green (solvent-free) and energy-saving method to prepare robust, highly electrically and thermally conductive polyamide nanocomposites is reported...
July 27, 2018: ACS Applied Materials & Interfaces
Mustafa Bozdemir
To know the impact of processing parameters of PA6G under different humidity conditions is important as it is vulnerable to humidity up to 7 %. This study investigated the effect of cutting parameters to surface roughness quality in wet and dry conditions. Artificial Neural Network (ANN) modeling is also developed with the obtained results from the experiments. Humidity condition, tool type, cutting speed, cutting rate, and depth of cutting parameters were used as input and average surface roughness value were used as output of the ANN model...
2018: Computational Intelligence and Neuroscience
Zhe Yang, Zhi-Wen Zhou, Hao Guo, Zhikan Yao, Xiao-Hua Ma, Xiaoxiao Song, Shien-Ping Feng, Chuyang Y Tang
Conventional thin-film composite (TFC) membranes suffer from the trade-off relationship between permeability and selectivity, known as the "upper bound". In this work, we report a high performance thin-film composite membrane prepared on a tannic acid (TA)-Fe nanoscaffold (TFCn ) to overcome such upper bound. Specifically, a TA-Fe nanoscaffold was first coated onto a polysulfone substrate, followed by performing an interfacial polymerization reaction between trimesoyl chloride (TMC) and piperazine (PIP)...
August 6, 2018: Environmental Science & Technology
Maria Kanelli, Mina Mandic, Margarita Kalakona, Sozon Vasilakos, Dimitris Kekos, Jasmina Nikodinovic-Runic, Evangelos Topakas
In the present study, crude bacterial extract containing violacein is investigated for the preparation of antimicrobial polyamide fabrics. The optimal culture conditions of Janthinobacterium lividum (JL) for maximum biomass and violacein production were found to be 25°C, pH 7.0, while the addition of ampicillin of 0.2 mg mL-1 in the small scale increased violacein production 1.3-fold. In scale-up trials, the addition of 1% (v/v) glycerol in a fed-batch bioreactor, resulted in fivefold extracted crude violacein increase with final concentration of 1...
2018: Frontiers in Microbiology
Tamyris de Souza E Silva Pegado, Kurt Schmid, Kirk O Winemiller, David Chelazzi, Alessandra Cincinelli, Luigi Dei, Tommaso Giarrizzo
This study investigated occurrence of microplastic particles in digestive tracts of fishes from the Amazon River estuary. A total of 189 fish specimens representing 46 species from 22 families was sampled from bycatch of the shrimp fishery. Microplastic particles removed from fish gastrointestinal tracts were identified using Attenuated Total Reflectance - Fourier Transform Infrared (ATR-FTIR). In total, 228 microplastic particles were removed from gastrointestinal tracts of 26 specimens representing 14 species (30% of those examined)...
August 2018: Marine Pollution Bulletin
Ragab E Abou-Zeid, Sawsan Dacrory, Korany A Ali, Samir Kamel
2,3,6‑Tricarboxy cellulose nanofiber (TPC-CNFs) was prepared by 2,2,6,6-tetramethylpiperidine‑1‑oxyl (TEMPO) oxidation of dissolving cellulose pulp (selective at C-6) followed by periodate-chlorite oxidation (selective on C-2 and C-3). Characterization of the prepared samples were carried out using, atomic force microscope (AFM), carboxylate content determination, FTIR spectroscopy, X-ray diffraction and light transmittance spectra. Also, the mechanical properties of TEMPO-oxidized of cellulose nanofiber (T-CNFs) and TPC-CNFs with and without polyamide-amine-epichlorohydrin crosslinker (PAE) films were determined which the tensile strength were 8...
July 20, 2018: International Journal of Biological Macromolecules
Kokiladevi Alagarswamy, Ken-Ichi Shinohara, Shihori Takayanagi, Masaki Fukuyo, Atsushi Okabe, Bahityar Rahmutulla, Natsumi Yoda, Rui Qin, Naoki Shiga, Masahiro Sugiura, Hiroaki Sato, Kazuko Kita, Takayoshi Suzuki, Tetsuhiro Nemoto, Atsushi Kaneda
Epigenome regulates gene expression to determine cell fate, and accumulation of epigenomic aberrations leads to diseases, including cancer. NCD38 inhibits lysine-specific demethylase-1 (LSD1), a histone demethylase targeting H3K4me1 and H3K4me2, but not H3K4me3. In this study, we conjugated NCD38 with a potent small molecule called pyrrole (Py) imidazole (Im) polyamide, to analyze whether targets of the inhibitor could be regulated in a sequence-specific manner. We synthesized two conjugates using β-Ala (β) as a linker, i...
June 29, 2018: Oncotarget
Chuanjie Fang, Jian Sun, Bin Zhang, Yuchen Sun, Liping Zhu, Hideto Matsuyama
Developing nanofiltration (NF) membranes with highly efficient and precise separation ability is of great significance for the molecular and ionic separations. In this work, positively charged composite NF membranes were engineered via soaking of polysulfone (PSF) ultrafiltration membranes in poly(N-vinyl imidazole) (PVI) solutions followed by a quaternization crosslinking step. The PVI was firmly attached to the PSF membrane by this method and acted as an active separation layer of the composite NF membrane...
July 18, 2018: Journal of Colloid and Interface Science
Juliana C Soares, Leonardo E O Iwaki, Andrey C Soares, Valquiria C Rodrigues, Matias E Melendez, José Humberto T G Fregnani, Rui M Reis, Andre L Carvalho, Daniel S Corrêa, Osvaldo N Oliveira
We report the fabrication of immunosensors based on nanostructured mats of electrospun nanofibers of polyamide 6 and poly(allylamine hydrochloride) coated either with multiwalled carbon nanotubes (MWCNTs) or gold nanoparticles (AuNPs), whose three-dimensional structure was suitable for the immobilization of anti-CA19-9 antibodies to detect the pancreatic cancer biomarker CA19-9. Using impedance spectroscopy, the sensing platform was able to detect CA19-9 with a detection limit of 1.84 and 1.57 U mL-1 for the nanostructured architectures containing MWCNTs and AuNPs, respectively...
October 31, 2017: ACS Omega
Eun Young Hong, Jin Young Kim, Roopali Upadhyay, Byung Jun Park, Jong Min Lee, Byung-Gee Kim
Ornithine decarboxylase (ODC) converts C5 ornithine into C4 putrescine, a monomer for polyamide synthesis. However, ODC also has minor activity towards cell metabolite C6 lysine and yields C5 cadaverine. The accumulation of cadaverine in the reaction solution causes increase in the operational cost of subsequent distillation process for putrescine purification. Here, to increase ODC substrate specificity toward ornithine over lysine, molecular modelling and protein network analysis, specifically k-clique community analysis, around the substrate tunnel were performed...
September 10, 2018: Journal of Biotechnology
Wenyue Jiang, Lihui Si, Pengdong Li, Bing Bai, Jiale Qu, Bao Hou, Hui Zou, Xing Fan, Zhiqiang Liu, Zhongying Liu, Lu Gao
Fenugreek is a well-known medicinal plant used for treatment of diabetes. In this study, the antidiabetic effect of fenugreek flavonoids was investigated by metabonomics based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Fenugreek flavonoids were purified using polyamide resin and D101 macroporous adsorption resin, characterized by UPLC-Q-TOF-MS, and administered to streptozotocin (STZ)-induced diabetic rats for 28 days. Pharmacological study results indicated that fenugreek flavonoids exerted a strong antidiabetic effect characterized by significant reduction of fasting blood glucose (P < 0...
August 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Zhehong Cheng, Wei Wang, Chunlei Wu, Xiaohua Zou, Lijing Fang, Wu Su, Pu Wang
Epstein-Barr virus (EBV) establishes latent infection and is associated with several types of lymphomas and carcinomas. EBV nuclear antigen 1 (EBNA1) is expressed in all EBV-positive tumor cells. EBNA1 binds to the origin of virus plasmid replication (OriP) on the EBV episome to initiate virus DNA replication and regulates virus gene expression as a transcriptional activator. In this study, we designed and synthesized a pyrrole-imidazole polyamide-Hoechst 33258 conjugate named EIP-2 (2), which specifically binds to the OriP region with high affinity, to interrupt EBNA1-OriP binding in vitro and in vivo...
July 30, 2018: Journal of Medicinal Chemistry
Mubbshir Saleem, Maria Cristina Lavagnolo, Giuseppe Concheri, Piergiorgio Stevanato, Andrea Squartini, Alessandro Spagni
This study investigated a novel bioreactor configuration coupled with a side-stream dynamic membrane (DM) for Anammox enrichment as an alternative for conventional membrane. Bioreactor was fed with synthetic feed and seeded with a mix of anaerobic and aerobic sludge. In situ mechanical cleaning was employed for DM cleaning. DM development and performance was analysed over two polyamide-nylon meshes (200 and 52 µm). Solid-liquid separation of 52 µm mesh outperformed 200 µm with an average effluent turbidity of 2...
October 2018: Bioresource Technology
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