Read by QxMD icon Read

Zinc oxide

T Yasui, R M Ehrhardt, G R Bowman, M Vázquez-Añon, J D Richards, C A Atwell, T R Overton
Trace minerals have important roles in immune function and oxidative metabolism; however, little is known about the relationships between supplementation level and source with outcomes in dairy cattle. Multiparous Holstein cows (n=48) beginning at 60 to 140 days in milk were utilized to determine the effects of trace mineral amount and source on aspects of oxidative metabolism and responses to intramammary lipopolysaccharide (LPS) challenge. Cows were fed a basal diet meeting National Research Council (NRC) requirements except for no added zinc (Zn), copper (Cu) or manganese (Mn)...
October 16, 2018: Animal: An International Journal of Animal Bioscience
Xuejun Jiang, Qianghu Tang, Jun Zhang, Hong Wang, Lulu Bai, Pan Meng, Xia Qin, Ge Xu, Diptiman D Bose, Bin Wang, Chengzhi Chen, Zhen Zou
Pulmonary exposure to zinc oxide nanoparticles (ZnONPs) could cause acute lung injury (ALI), but the underlying molecular mechanism remains unclear. Herein, we established a ZnONPs-induced ALI mouse model, characterized by the histopathological changes (edema and infiltration of inflammatory cells in lung tissues), and the elevation of total protein and cytokine interleukin-6 in bronchoalveolar lavage fluid in time- and dose-dependent manners. This model also exhibited features like the disturbance of redox-state (reduced of glutathione to glutathione disulfide ratio, elevation of heme oxygenase-1 and superoxide dismutase 2), the decrease of adenosine triphosphate synthesis and the release of zinc ions in the lung tissues...
October 14, 2018: Nanotoxicology
Łukasz Lewandowski, Marta Kepinska, Halina Milnerowicz
Copper-zinc superoxide dismutase (Cu,Zn-SOD) plays a protective role in various types of tissue protecting them from oxidative damage. Alterations in copper-zinc superoxide dismutase (SOD1 and SOD3) activity and its expression has been observed in pathological occurrences most prevalent in modern society, including: inflammatory bowel disease, obesity and its implications - diabetes and hypertension, and chronic obstructive pulmonary disease. Moreover, several SOD1 and SOD3 gene polymorphisms have been associated with the risk of developing a particular type of disease, or its exacerbation...
October 13, 2018: European Journal of Clinical Investigation
Shreyasi Asthana, Zaved Hazarika, Parth Sarathi Nayak, Jyoti Roy, Anupam Nath Jha, Bibekanand Mallick, Suman Jha
BACKGROUND: Injection localized amyloidosis is one of the most prevalent disorders in type II diabetes mellitus (TIIDM) patients relying of insulin injections. Previous studies have reported that nanoparticles can play a role in the amyloidogenic process of proteins. Hence, the present study deals with the effect of zinc oxide nanoparticles (ZnONP) on the amyloidogenicity and cytotoxicity of insulin. METHODS: ZnONP is synthesized and characterized using XRD, Zeta Sizer, UV-Visible spectroscope and TEM...
October 10, 2018: Biochimica et biophysica acta. General subjects
Beimi Cui, Qiaona Pan, David Clarke, Marisol Ochoa Villarreal, Saima Umbreen, Bo Yuan, Weixing Shan, Jihong Jiang, Gary J Loake
Nitric oxide (NO) orchestrates a plethora of incongruent plant immune responses, including the reprograming of global gene expression. However, the cognate molecular mechanisms remain largely unknown. Here we show a zinc finger transcription factor (ZF-TF), SRG1, is a central target of NO bioactivity during plant immunity, where it functions as a positive regulator. NO accumulation promotes SRG1 expression and subsequently SRG1 occupies a repeated canonical sequence within target promoters. An EAR domain enables SRG1 to recruit the corepressor TOPLESS, suppressing target gene expression...
October 12, 2018: Nature Communications
Rania Ben Saad, Anis Ben Hsouna, Walid Saibi, Karim Ben Hamed, Faical Brini, Thaura Ghneim-Herrera
Agricultural soil pollution by heavy metals is a severe global ecological problem. We recently showed that overexpression of LmSAP, a member of the stress-associated protein (SAP) gene family isolated from Lobularia maritima, in transgenic tobacco led to enhanced tolerance to abiotic stress. In this study, we characterised the response of LmSAP transgenic tobacco plants to metal stresses (cadmium (Cd), copper (Cu), manganese (Mn), and zinc (Zn)). In L. maritima, LmSAP expression increased after 12 h of treatment with these metals, suggesting its involvement in the plant response to heavy metal stress...
September 29, 2018: Journal of Plant Physiology
Nan You, Hui Yao, Yun Wang, Hong-Tao Fan, Chang-Song Wang, Ting Sun
The pollution of antibiotics, including tetracyclines (TCs), in aquatic environments has become an issue of concern in recent years. Herein, an in situ sampling of TCs in pig breeding wastewater that utilizes the technique of diffusive gradients in thin films (DGT), based on commercial nanosized ZnO (nanoZnO) particles as the potential effective binding agent and a polyethersulfone (PES) membrane as the diffusion layer, was developed. The diffusion coefficients of tetracycline (TC), oxytetracycline (OTC) and chlortetracycline (CTC) in a PES membrane at 25 °C were (1...
September 25, 2018: Science of the Total Environment
Hoda H Anan, Rania A Zidan, Samia A Abd El-Baset, Manar M Ali
Despite its wide range of application, cyclophosphamide (CP) exhibits a wide range of adverse effects including reproductive toxicity. The emerging field of zinc oxide nanoparticles (ZnO NPs) therapy may provide a new hope for prevention of CP induced gonadal toxicity. Herein, we aim to investigate the possible role of ZnO NPs as a new strategy to protect against CP induced testicular injury. Sixty adult male albino rats were divided into 3 groups; control, CP treated and CP + ZnO NPs treated groups. CP group was injected with CP (5 mg/kg/day), whereas CP + ZnO NPs group was concomitantly injected with CP and ZnO NPs (5 mg/kg/day)...
October 2018: Tissue & Cell
Myung Hwangbo, Everett Caleb Claycomb, Yina Liu, Theodore E G Alivio, Sarbajit Banerjee, Kung-Hui Chu
Microbial and emerging chemical contaminants are unwanted constituents in reclaimed wastewater, due to the health concerns of using the water for agricultural irrigation, aquifer recharges, and potable water. Removal of these contaminants is required but it is currently challenging, given that there is no simple treatment technology to effectively remove the mixture of these contaminants. This study examined the effectiveness of ZnO-assisted photocatalytic degradation of several constituents, including 1,4-dioxane, trihalomethanes (THMs), triclosan (TCS), triclocarban (TCC), antibiotic resistant bacteria (ARB) and antibiotic resistant genes (ARGs), under low intensity of UV exposure...
February 1, 2019: Science of the Total Environment
Yue Meng, Se Wang, Zhuang Wang, Nan Ye, Hao Fang
The present study investigated the impacts of dissolved organic matters (DOM) on joint toxicity involved in zinc oxide nanoparticles (ZnO NPs) and tetrabromobisphenol A (TBBPA) at relevant low-exposure concentrations (<1 mg/L). It was found that ZnO NPs in single and combined systems exhibited severe inhibition effects on a freshwater microalgae Scenedesmus obliquus. However, the presence of DOM slightly alleviated the growth inhibition toxicity induced by the binary mixtures of ZnO NPs and TBBPA. Ultrastructure analysis revealed that ZnO NPs caused structural damage to cells, including plasmolysis, membrane destruction, and the disruption of thylakoid in the chloroplast, regardless of the presence of coexisting substances...
September 25, 2018: Environmental Toxicology and Pharmacology
Andrea Matos, Vanessa Moreira da Silveira Gonçalves, Gisele Souza, Suelem Pereira da Cruz, Sabrina Cruz, Andréa Ramalho
INTRODUCTION: the purpose of this study was to assess the vitamin A (VA) nutritional status of patients with coronary artery disease (CAD) and its correlation with the severity of the disease, taking into consideration zinc concentration and oxidative stress. METHODS: the patients were preoperative inpatients awaiting myocardial revascularization surgery. The serum concentrations of retinol, β-carotene, zinc, malondialdehyde (MDA) and C-reactive protein (CRP) were quantified...
October 8, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Yi Jia, Jie Dai, Liangliang Zhang, Huan Xia
Aging has been related to zinc deficiency, resulting in protein oxidation and age-related decline of methionine sulfoxide reductase (Msr) activity. This study was designed to investigate the levels of methionine sulfoxide reductase B1 (MsrB1) mRNA and oxidized proteins in human lens epithelial (hLE) cells after treatment with exogenous zinc. The role of exogenous zinc in regulation of MsrB1 gene expression and protein oxidation in hLE cells was studied by MTT assay, oxidized protein measurement kit, and real-time PCR...
October 10, 2018: Biological Trace Element Research
M Ugarte, K Geraki, G Jeffery
We present further analyses of a previous experiment published in 2016 where the distribution, concentration and correlation of iron, zinc, copper and sulphur in the choroid of the eye in young and aged old world primates (Macaca fascicularis) was studied with synchrotron X-ray fluorescence with a 2 μm resolution. The results indicate that iron accumulates in hotspots in the choroid with age with fluorescence intensity ranging from 2- to 7-fold (1002-3752 ppm) the mean level in the choroidal stroma (500 ppm) and maximum iron levels in blood vessel lumina...
October 10, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Hui Wang, Sofia Abassi, Jang-Seu Ki
Superoxide dismutase (SOD) acts as the first line of defence against reactive oxygen species (ROS) within cells. In this study, we characterized a novel SOD gene (PmCuZnSOD) from the dinoflagellate, Prorocentrum minimum, and examined its structural features, putative origin, and gene expression. The SOD cDNA is 895 bp in length, containing dinoflagellate splice-leader (dinoSL) sequence, 714-bp ORF (237 aa), and poly (A) tail. In addition, PmCuZnSOD is coded on the dinoflagellate nuclear genome without introns and in a non-tandem repeat manner; however, the encoded protein is probably localized in chloroplasts...
October 7, 2018: Gene
Dilip Kumar Ghosh, Sunil Kokane, Pranav Kumar, Ali Ozcan, Ashish Warghane, Manali Motghare, Swadeshmukul Santra, Ashwani Kumar Sharma
Huanglongbing (HLB, also known as citrus greening) is considered to be the most devastating disease that has significantly damaged the citrus industry globally. HLB is caused by the Candidatus Liberibacter asiaticus (CLas), the fastidious phloem-restricted gram-negative bacterium, vectored by the asian citrus psyllid. To date, there is no effective control available against CLas. To alleviate the effects of HLB on the industry and protect citrus farmers, there is an urgent need to identify or develop inhibitor molecules to suppress or eradicate CLas from infected citrus plant...
2018: PloS One
Abani Kumar Patar, Anupama Sharma, Donkupar Syiem, Surya Bhan
Chlorophyllin is a water-soluble mixture of sodium-copper salts of chlorophyll with antioxidant and antimutagen properties. In this study, an attempt has been made to evaluate the effect of chlorophyllin on hyperglycemia-induced oxidative stress and apoptosis in liver of streptozotocin (STZ)-administered mice. In STZ-induced diabetes, two causative factors for pancreatic β-cell deaths are DNA alkylation and profound reactive oxygen species (ROS) generation. In this study, chlorophyllin treatment was found to be able to modulate oxidative stress and apoptosis in liver of diabetic mice...
October 10, 2018: BioFactors
Magdalena Szumska, Aleksandra Damasiewicz-Bodzek, Justyna Czubilińska, Michał Długaszek, Kaja Gawlik, Anna Krywult, Konrad Synowiec, Tomasz Wielkoszyński, Krystyna Tyrpień-Golder
Pregnancy-associated plasma protein A (PAPP-A) is a high-molecular zinc-binding metalloproteinase that was first detected in the serum of pregnant women. It can also be detected in men and non-pregnant women. Recently, a growing interest in determining the concentration of PAPP-A as a marker of oxidative stress and atherosclerotic processes has been observed. Among the factors that could potentially influence the PAPP-A formation is the exposure to tobacco smoke. Some components of tobacco smoke have an immediate effect on the body and also direct influence on the cardiovascular system...
October 9, 2018: Cardiovascular Toxicology
Virendra Kumar Parashar, Martin Gijs
Dynamic deposition of ZnO nanostructures with varying morphologies (nanorods, nanocones, nanopencils, nanosheets, etc.), diameters, lengths and aerial densities on ITO-PET substrates has been achieved using a continuous flow microreactor in which we maintained a homeostatic zinc concentration and varied the other reactants' concentrations.
October 10, 2018: Chemical Communications: Chem Comm
N C N Perera, G I Godahewa, Sumi Jung, Myoung-Jin Kim, Bo-Hye Nam, Jehee Lee
Complement system orchestrates the innate and adaptive immunity via the activation, recruitment, and regulation of immune molecules to destroy pathogens. However, regulation of the complement is essential to avoid injuries to the autologous tissues. The present study unveils the characteristic features of an important complement component, anaphylatoxin inactivator from red lip mullet at its molecular and functional level. Mullet carboxypeptidase N1 (MuCPN1) cDNA sequence possessed an open reading frame of 1347 bp, which encoded a protein of 449 amino acids with a predicted molecular weight of 51 kDa...
October 6, 2018: Fish & Shellfish Immunology
Qi Sun, Jianmei Li, Tao Le
Certain types of nanoparticles, especially nanoscale zinc oxide (ZnONP), are widely reported to be capable of the inhibition of harmful bacteria, yeasts and filamentous fungi. The unique physicochemical and biological properties of ZnONP also make them attractive to the food industry for use as a promising antifungal agent. This review thoroughly introduced the preparation methods and antifungal properties of ZnONP, and analyzed its possible antifungal mechanisms. The applicability of ZnONP in food packaging, nutritional supplements and as an antimicrobial additive are also documented...
October 9, 2018: Journal of Agricultural and Food Chemistry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"