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Antibacterial Effect

Bin Lee, Jae Sam Hwang, Dong Gun Lee
Periplanetasin-2 is a 15-mer antimicrobial peptide (AMP), derived from the American cockroach Periplaneta americana. This novel AMP exhibits potent antibacterial effect against several pathogenic bacteria including Escherichia coli. Distinct from the targeting cell membrane, which is the general antibacterial mechanism of AMP, periplanetasin-2 exerts its antibacterial activity via apoptosis-like death, which is physiologically and mechanistically similar to eukaryotic apoptosis. E. coli cells treated with periplanetasin-2 showed features of apoptosis in a concentration-dependent manner, such as membrane depolarization, DNA fragmentation, caspase-like protein activation, and phosphatidylserine externalization...
December 15, 2018: Applied Microbiology and Biotechnology
Apoorva Goel, Mukesh Kumar Meher, Payal Gupta, Khushboo Gulati, Vikas Pruthi, Krishna Mohan Poluri
Maturation of bacterial biofilms and their resistance to recurrent antimicrobial agents results in convoluted infectious diseases. In the current study, kappa-Carrageenan (κ-Carrageenan/CRG), was used to formulate CRG-silver nanocomposites through a facile microwave green synthesis approach. CRG-Ag nanoparticles of size 50 ± 10 nm were obtained by using CRG as a reducing and stabilizing agent. CRG-Ag nanoparticles were highly effective against both S. aureus and P. aeruginosa mediated biofilms and acted as a broad spectrum antibacterial agent even after six months...
February 15, 2019: Carbohydrate Polymers
Lin Lin, Xuefang Mao, Yanhui Sun, Govindan Rajivgandhi, Haiying Cui
This study was aimed to develop novel antibacterial packaging materials in order to reduce the microbial contamination of food surface. Chrysanthemum essential oil (CHEO) was successfully incorporated into chitosan nanofibers (CS/NF) through electrospinning which was demonstrated by SEM and AFM analysis. The antibacterial mechanism of CHEO against Listeria monocytogenes (L. monocytogenes) was explored as well. The cell membrane permeability of L. monocytogenes appeared to be increased by CHEO. In addition, respiratory metabolism of L...
December 8, 2018: International Journal of Food Microbiology
Alex Carignan, Robert Sabbagh, Vincent Masse, Nicolas Gagnon, Louis-Philippe Montpetit, Marc-Andre Smith, Mathieu Raymond, Catherine Allard, Cybèle Bergeron, Jacques Pépin
BACKGROUND: Rates of infection following ultrasound-guided transrectal prostate needle biopsy (TRUSPB) are increasing. We aimed to evaluate the effectiveness of fosfomycin tromethamine (FMT) prophylaxis in preventing post-TRUSPB infectious complications. METHODS: This nested case-control study included patients who underwent TRUSPB in a Canadian tertiary care hospital, and developed post-TRUSPB bacteremia or urinary tract infections. Four prophylaxis periods included: i) ciprofloxacin, low-resistance period (CIPRO-LOW), 2002-2009; ii) ciprofloxacin, high-resistance period (CIPRO-HIGH), 2010-October 2013; iii) oral FMT, one dose (FOSFO1), December 2013-September 2015; and iv) oral FMT, two doses (FOSFO2), October 2015-June 2016...
December 12, 2018: Journal of Global Antimicrobial Resistance
Prabhat Upadhyay, Sunil Kumar Mishra, Awadhesh Kumar Mishra, Pradeep Kumar, Nidhi Pandey, Kavindra Nath Tiwari, Ragini Tilak, Suresh Purohit, G P Dubey
Reinwardtia indica (Lineceae) is a medicinal plant cultivated in the Himalayan region. It is effectively used in folk medicines for the treatment of various health complications. In the present study, the shade dried leaves and stem were extracted in three different solvents such as ethyl acetate, ethanol, and hydro-alcoholic. The antioxidant efficacy of these extracts was confirmed by using different in vitro assays: DPPH free radical scavenging, superoxide radical scavenging, lipid peroxidation, metal ion chelating capability and reducing power determination...
December 12, 2018: Microbial Pathogenesis
Renato Rocha Martins, Lunara Teles Silva, Flavio Marques Lopes
Background Drug-related problems are mostly preventable or predictable circumstances that may impact on health outcomes. Clinical pharmacy activities such as medication therapy management can identify and solve these problems, with potential to improve medication safety and effectiveness. Objective To evaluate ability of medication therapy management service to detect drug-related problems and prevent adverse drug events. This study also aimed to assess the risk factors for drugrelated problem occurrence. Setting Medical intensive care unit of a public tertiary hospital in Brazil...
December 15, 2018: International Journal of Clinical Pharmacy
Maria Luísa Leite, Diana Gabriela Soares, Carla Caroline de Oliveira Duque, Ester Alves Ferreira Bordini, Giovana Anovazzi, Fernanda Gonçalves Basso, Denise Madalena Palomari Spolidorio, Josimeri Hebling, Carlos Alberto de Souza Costa
OBJECTIVES: To assess the biological, antimicrobial, and mechanical effects of the treatment of deep dentin with simvastatin (SV) before application of a glass-ionomer cement (GIC). MATERIALS AND METHODS: Dentin discs were adapted to artificial pulp chambers and SV (2.5 or 1.0 mg/mL) was applied to the occlusal surface, either previously conditioned or not with EDTA (±EDTA). The extracts (culture medium + SV that diffused through dentin) was obtained and then applied to cultured odontoblast-like MDPC-23 cells...
December 14, 2018: Clinical Oral Investigations
Tamoghna Ghosh, Santosh Kumar Srivastava, Amit Gaurav, Alok Kumar, Piyush Kumar, Ajit Singh Yadav, Ranjana Pathania, Naveen Kumar Navani
Inappropriate and disproportionate use of antibiotics is contributing immensely to the development of antibiotic resistance in bacterial species associated with food contamination. Use of natural products in combination can be a potent alternative hurdle strategy to inactivate foodborne pathogens. Here, we explored pro-oxidant properties of essential oil <u>l</u>inalool and <u>v</u>itamin C in combination with <u>c</u>opper (LVC) in combating foodborne pathogens Vibrio fluvialis and a Salmonella enterica subsp...
December 14, 2018: Applied and Environmental Microbiology
Samuggam Sumitha, Sethu Vasanthi, Sivadasan Shalini, Suresh V Chinni, Subash C B Gopinath, Periasamy Anbu, Mohammed Baidi Bahari, Rajak Harish, Sathasivam Kathiresan, Veerasamy Ravichandran
In the present study, we have developed a green approach for the synthesis of silver nanoparticles (DSAgNPs) using aqueous extract of Durio zibethinus seed and determined its antibacterial, photocatalytic and cytotoxic effects. Surface plasmon resonance confirmed the formation of DSAgNPs with a maximum absorbance (λmax ) of 420 nm. SEM and TEM images revealed DSAgNPs were spherical and rod shaped, with a size range of 20 nm and 75 nm. The zeta potential was found to be -15.41 mV. XRD and EDX analyses confirmed the nature and presence of Ag and AgCl...
December 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Marina Pereira Rocha, Priscilla Rodrigues Valadares Campana, Denise de Oliveira Scoaris, Vera Lucia de Almeida, Julio Cesar Dias Lopes, Julian Mark Hugh Shaw, Claudia Gontijo Silva
This paper reports the in silico prediction of biological activities of lignans from Diphylleia cymosa and Podophyllum hexandrum combined with an in vitro bioassays. The extracts from the leaves, roots and rhizomes of both species were evaluated for their antibacterial, anticholinesterasic, antioxidant and cytotoxic activities. A group of 27 lignans was selected for biological activities prediction using the Active-IT system with 1987 ligand-based bioactivity models. The in silico approach was properly validated and several ethnopharmacological uses and known biological activities were confirmed, whilst others should be investigated for new drugs with potential clinical use...
December 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Marta Martínez-Pérez, Ana Conde, María-Angeles Arenas, Ignacio Mahíllo-Fernandez, Juan-José de-Damborenea, Ramón Pérez-Tanoira, Concepción Pérez-Jorge, Jaime Esteban
OBJECTIVE: Implant-related infection is a devastating complication in orthopedic surgery. Aiming to minimize this problem, many material modifications have been developed. Here we report a study of a surface modification of Ti-6 Al-4 V alloy using a methodology that enables the study of interactions between bacteria and the material in the presence of eukaryotic cells. METHODS: We mixed different concentrations of collection or clinical strains of staphylococci isolated from implant-related infections with preosteoblastic cells using a previously published methodology, analyzing the minimal concentration of bacteria able to colonize the surface of the material through image analysis...
January 1, 2019: Colloids and Surfaces. B, Biointerfaces
Tingting Yang, Donghui Wang, Xuanyong Liu
Titanium and its alloys are widely used in many clinical applications, but implant-associated infection may lead to implant failure. Because of the increasing concern about antibiotic resistant pathogen, photothermal therapy (PTT) as a new treatment strategy has received considerable attention. In this work, gold nanorods (GNRs) photoexcited by the near-infrared (NIR) light were immobilized on Ti surface by electrostatic surface self-assembly technique. Field emission scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) were used to explore the morphology and composition of the GNRs-modified surface...
January 1, 2019: Colloids and Surfaces. B, Biointerfaces
Agni Kumar Biswal, Sampa Saha
Biodegradable polymer based 'controlled release packaging' technology has ability to release packaging actives in controlled manner to prolong the food shelf-life. Currently available systems are not sufficiently capable of releasing multiple actives in sustainable fashion. Hence, the purpose of this study was to develop dual actives (antioxidant and antibacterial) loaded multilayered microparticles in one step and to release them at rates suitable for long-term inhibition of bacterial growth as well as lipid oxidation in food...
December 4, 2018: Colloids and Surfaces. B, Biointerfaces
Takashi Azuma, Kana Otomo, Mari Kunitou, Mai Shimizu, Kaori Hosomaru, Shiori Mikata, Mao Ishida, Kanae Hisamatsu, Ayami Yunoki, Yoshiki Mino, Tetsuya Hayashi
Environmental fate of 58 pharmaceutical compounds (PhCs) grouped into 11 therapeutic classes in the three different waters, hospital effluent, sewage treatment plant (STP) and river water, was estimated by combination of their quantitative concentration analysis and evaluation of their extent of contribution as loading sources. At the same time, distribution of six classes of antimicrobial-resistant bacteria (AMRB) in the same water samples was estimated by screening of individual PhC-resistant microbes grown on each specific chromogenic medium...
December 3, 2018: Science of the Total Environment
Srivithya Vellampatti, Gopalakrishnan Chandrasekaran, Sekhar Babu Mitta, Sreekantha Reddy Dugasani, Vinoth-Kumar Lakshmanan, Sung Ha Park
DNA nanotechnology has laid a platform to construct a variety of custom-shaped nanoscale objects for functionalization of specific target materials to achieve programmability and molecular recognition. Herein, we prepared DNA nanostructures [namely, synthetic DNA rings (RDNA) and DNA duplexes extracted from salmon (SDNA)] containing metal ions (M2+ ) such as Cu2+ , Ni2+ , and Zn2+ as payloads for delivery to exterminate highly pathologic hospital bacterial strains (e.g., Escherichia coli and Bacillus subtilis) and prostate cancer cells (i...
December 14, 2018: ACS Applied Materials & Interfaces
Maryam Labibzadeh, Gholam Abbas Kaydani, Mohammad Savari, Alireza Ekrami
Enterococcus faecalis and Enterococcus faecium are among the main agents associated with nosocomial infections with high mortality in immunocompromised patients. Antibiotic resistance, especially against gentamicin and vancomycin among Enterococci , is a risk factor that could increase the morbidity and mortality rate. 179 Enterococci isolates from burn patients were included in this study. Antibiotic susceptibility testing was done using the disk diffusion test and minimum inhibitory concentration (MIC) was evaluated by agar microdilution...
2018: Polish Journal of Microbiology
Qian Wang, Shumei Cui, Li Zhou, Keke He, Liya Song, Haiyan Liang, Congfen He
BACKGROUND/AIMS: Healthy skin harbors numerous microbes known to maintain its health and prevent attacks from external pathogens. The influence of chemical preservatives commonly used in cosmetic products on facial resident flora remains poorly characterized. In this study, we aimed to investigate the antibacterial activity of five such preservatives on in vitro cultivated skin-resident bacteria. METHODS: Both Gram-positive and Gram-negative bacteria were isolated on blood agar, tryptic soy agar, and nutrient agar; Gram-negative bacteria were then selected on Hank's balanced salt solution containing antibiotics and Reasoner's 2A...
December 12, 2018: Journal of Cosmetic Dermatology
Shilpi Tiwari, Chethana S Murthy, H L Usha, A K Shivekshith, N Naveen Kumar, L Vijayalakshmi
Aim of the Study: Bacteria that persist at the time of obturation increase the possibility of persistent apical periodontitis. An ideal sealer should be able to kill these remaining bacteria that are present on the dentinal walls as well as inside the dentinal tubules. This could be possible if a sealer has antimicrobial properties with optimum flow characteristics. Hence, the aim of this in vitro study was to assess the antimicrobial efficacy of epoxy resin-based sealer: AH Plus and Perma Evolution against Enterococcus faecalis on the 1st , 3rd , 5th , and 7th day and also to compare the flow characteristics of both epoxy resin-based sealers...
November 2018: Journal of Conservative Dentistry: JCD
Una Glamočlija, Subhash Padhye, Selma Špirtović-Halilović, Amar Osmanović, Elma Veljović, Sunčica Roca, Irena Novaković, Boris Mandić, Iztok Turel, Jakob Kljun, Snežana Trifunović, Emira Kahrović, Sandra Kraljević Pavelić, Anja Harej, Marko Klobučar, Davorka Završnik
Thymoquinone ( TQ ), a natural compound with antimicrobial and antitumor activity, was used as the starting molecule for the preparation of 3-aminothymoquinone ( ATQ ) from which ten novel benzoxazole derivatives were prepared and characterized by elemental analysis, IR spectroscopy, mass spectrometry and NMR (¹H, 13 C) spectroscopy in solution. The crystal structure of 4-methyl-2-phenyl-7-isopropyl-1,3-benzoxazole-5-ol ( 1a ) has been determined by X-ray diffraction. All compounds were tested for their antibacterial, antifungal and antitumor activities...
December 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mohamed E Khalifa, Adil A Gobouri, Fahad M Kabli, Tarik A Altalhi, Abdulraheem S A Almalki, Mahmoud A Mohamed
The paper describes the synthesis and biological evaluation of some new benzimidazole derivatives as potent clinical drugs that are useful in the treatment of some microbial infections and tumor inhibition. The starting compound 2-(bromomethyl)-1 H -benzimidazole ( 1 ) was prepared, and hence underwent interesting functionalization reactions to afford several series of benzimidazole-5-(aryldiazenyl)thiazole derivatives: 3a ⁻ c , 7a ⁻ c , and 8a ⁻ c . The antibacterial activities of the synthesized compounds were evaluated by calculation of the inhibition zone diameter (mm) and the determination of minimum inhibitory concentration (µg/mL) against selected pathogenic bacteria Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria)...
December 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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