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Antibacterial Effect

Ollie Y Yu, Irene S Zhao, May L Mei, Edward C M Lo, C H Chu
OBJECTIVES: To investigate the remineralising effect and bacterial growth inhibition of 38% silver diamine fluoride (SDF) solution and 5% sodium fluoride (NaF) varnish on artificial dentine caries lesions. METHODS: Demineralised dentine blocks were treated with SDF + NaF (Group 1), SDF (Group 2), NaF (Group 3) and water (Group 4) and subjected to a Streptococcus mutans biofilm challenge. Lesion depth, precipitates' characteristics and matrix (collagen)-to-mineral ratio were evaluated by micro-computer tomography (micro-CT), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), respectively...
August 13, 2018: Journal of Dentistry
Nazanin Zargar, Motahare Rayat Hosein Abadi, Mohammad Sabeti, Zahra Yadegari, Alireza Akbarzadeh Baghban, Omid Dianat
This study compared the antibacterial effect of 2% clindamycin and 2% and 100% concentration of triple antibiotic paste (TAP) on an Enterococcus faecalis biofilm. Dentinal tubules of 100 root specimens were infected and randomly assigned to five groups. A total of 1000 mg mL-1 of TAP, 20 mg mL-1 of TAP and clindamycin, calcium hydroxide or methylcellulose (control) were placed in the root canal for 1 week. After treatment, dentine shavings were collected from 200 and 400 μm dentine depth and the number of colony-forming units (CFU) per mg was determined...
August 16, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
Tian-Tian Yue, Xiao Li, Xiao-Xiong Wang, Xu Yan, Miao Yu, Jian-Wei Ma, Yu Zhou, Seeram Ramakrishna, Yun-Ze Long
Electrospinning provides an effective method for generating nanofibers from solution of carboxymethyl chitosan/polyoxyethylene oxide (CMCS/PEO). The goal of this work is to explore the potential application of electrospun CMCS/PEO nanofiber membrane in fruit fresh-keeping. The microstructure, antibacterial activity, hydrophilia, and air permeability of the nanofiber membrane have been tested. For comparison, the fresh-keeping effects of commercial cling wrap and CMCS/PEO nanofiber membranes on strawberries' rotting rate and weight loss rate have been studied...
August 15, 2018: Nanoscale Research Letters
Balasubramani Govindasamy, Deepak Paramasivam, Aiswarya Dilipkumar, Karthik Raja Ramalingam, Kamaraj Chinnaperumal, Perumal Pachiappan
Presently, the discovery of effective drugs and pesticides from eco-friendly biological sources is an important challenge in the field of life sciences. The present research was aimed for standardizing an innovative approach in the evaluation of the biological potentiality of the metabolites of fish-associated bacteria. We have identified 17 skin-associated bacteria from the freshwater fish, giant danio, Devario aquipinnatus. They were screened through biofilm forming and extracellular enzyme producing ability...
August 15, 2018: Environmental Science and Pollution Research International
Cijun Shuai, Yuanzhuo Zhou, Youwen Yang, Chengde Gao, Shuping Peng, Guoyong Wang
Bone implants are expected to possess antibacterial ability and favorable biodegradability. Ag possesses broad-spectrum antibacterial effects through destroying the respiration and substance transport of bacteria. In this study, Ag was introduced into Mg-3Zn-0.5Zr (ZK30) via selective laser melting technology. Results showed that ZK30-Ag exhibited a strong and stable antibacterial activity against the bacterium Escherichia coli. Moreover, the degradation resistance was enhanced due to the comprehensive effect of positive shifted corrosion potential (from -1...
2018: BioMed Research International
Sofia Cosentino, Silvia Viale, Maura Deplano, Maria Elisabetta Fadda, Maria Barbara Pisano
Fungal spoilage is one of the main causes of economic losses worldwide in the food industry. In the last years, consumer's demands for preservative-free processed foods have increased as a result of growing awareness about the health hazards associated with chemicals. Lactic acid bacteria have been extensively studied for their antibacterial and antifungal potential in order to be used as biopreservatives. The first objective of this study was to investigate in vitro the antifungal activity of autochthonous Lactobacillus strains against moulds commonly associated with cheese spoilage...
2018: BioMed Research International
Marzieh Sobhani, Mahdi Abbas-Mohammadi, Samad Nejad Ebrahimi, Atousa Aliahmadi
Background and Objectives: Due to the importance of finding new and more effective antifungal and antibacterial compounds against invasive vaginitis strains, this study was conducted for fast screening of plant samples. Materials and Methods: Thirty Iranian plant samples were successively extracted by n -hexane, ethyl acetate and methanol to obtain a total of 90 extracts. Each extract was prepared in six concentrations and evaluated for antifungal activity via a micro-broth dilution method...
June 2018: Iranian Journal of Microbiology
Sheida Mohammadi, Nima Hosseini Jazani, Mehri Kouhkan, Leila Ashrafi Babaganjeh
Background and Objectives: Bacterial resistance is an emerging public health problem worldwide. Metallic nanoparticles and nanoalloys open a promising field due to their excellent antimicrobial effects. The aim of the present study was to investigate the antibacterial effects of Ag-Cu nanoalloys, which were biosynthesized by Lactobacillus casei ATCC 39392, on some of the important bacterial pathogens, including Escherichia coli , Burkholderia cepacia, Listeria monocytogenes and Brucella abortus ...
June 2018: Iranian Journal of Microbiology
Blessing O Oyedemi, Sunday O Oyedemi, Johnson V Chibuzor, Ifeoma I Ijeh, Roger M Coopoosamy, Ayobami O Aiyegoro
Oral and skin infections contribute significantly to the global health challenges responsible for the current trend of increased morbidity and premature death. The purpose of this study was to document medicinal plants used in the management of oral and skin infections in Ebem-Ohafia Local Government Area (LGA), Abia State, and to characterize the in vitro antioxidant and antibacterial activity. The thin layer chromatography (TLC) profiling of ten of the selected folklore medicine was carried out using a various solvent system of different polarity index...
2018: TheScientificWorldJournal
Maria João Catalão, Madalena Pimentel
Mycobacteriophages are viruses that specifically infect mycobacteria, which ultimately culminate in host cell death. Dedicated enzymes targeting the complex mycobacterial cell envelope arrangement have been identified in mycobacteriophage genomes, thus being potential candidates as antibacterial agents. These comprise lipolytic enzymes that target the mycolic acid-containing outer membrane and peptidoglycan hydrolases responsive to the atypical mycobacterial peptidoglycan layer. In the recent years, a remarkable progress has been made, particularly on the comprehension of the mechanisms of bacteriophage lysis proteins activity and regulation...
August 14, 2018: Viruses
Rashid Ahmed, Muhammad Tariq, Imran Ali, Rehana Asghar, P Noorunnisa Khanam, Robin Augustine, Anwarul Hasan
Non-healing wound is a serious complication of diabetes, associated with extremely slow wound closure, and a high rate of infection, resulting in amputation or losses of limbs, high health care cost and poor quality of patient's life. In the present study, we hypothesized that nanofiber mats composed of a combination of chitosan, polyvinyl alcohol (PVA) and Zinc oxide (ZnO) could be an effective option for faster healing of diabetic wounds due to the wound healing activities of chitosan-PVA nanofibers and antibacterial properties of ZnO...
August 12, 2018: International Journal of Biological Macromolecules
Davide Carta, Paola Brun, Matteo Dal Pra, Giulia Bernabè, Ignazio Castagliuolo, Maria Grazia Ferlin
Our aim was to identify new multi-target compounds endowed with both anti-inflammatory and anti-bacterial activities for treatment of human infections. Diflunisal, a nonsteroidal anti-inflammatory agent, has recently been repurposed for its anti-virulence properties against methicillin-resistant Staphylococcus aureus . Effective synthesis of some aza-analogs of the anti-inflammatory drug diflunisal was carried out following the route involving key oxazole intermediates to obtain o - and m -hydroxypyridinecarboxylic acid derivatives...
June 1, 2018: MedChemComm
Youchao Deng, Dingding Kang, Jie Shi, Wenqing Zhou, Aijun Sun, Jianhua Ju, Xiangcheng Zhu, Ben Shen, Yanwen Duan, Yong Huang
A dozen oxime, hydrazine and hydrazide derivatives of platensimycin (PTM) analogues were synthesized, some of which showed strong antibacterial activities and were shown to be stable under the bioassay conditions. Docking analysis revealed that they have certain new interactions with β-ketoacyl-[acyl carrier protein] synthase II (FabF), suggesting that Schiff base formation on its terpene scaffold is an effective strategy to diversify PTM structure.
May 1, 2018: MedChemComm
G M L Consoli, G Granata, R Picciotto, A R Blanco, C Geraci, A Marino, A Nostro
The growing antibiotic resistance phenomenon continues to stimulate the search for new compounds and strategies to combat bacterial infections. In this study, we designed and synthesized a new polycationic macrocyclic compound ( 2 ) bearing four N -methyldiethanol ammonium groups clustered and circularly organized by a calix[4]arene scaffold. The in vitro activity of compound 2 , alone and in combination with known antibiotics (ofloxacin, chloramphenicol or tetracycline), was assessed against strains of Staphylococcus aureus (ATCC 6538 and methicillin-resistant isolate 15), S...
January 1, 2018: MedChemComm
Aijaz Ahmad, Mohmmad Younus Wani, Mrudula Patel, Abilio J F N Sobral, Adriano G Duse, Faisal Mohammed Aqlan, Abdullah Saad Al-Bogami
The occurrence of invasive fungal diseases, particularly in immunocompromised patients, is life-threatening and increases the economic burden. The rising problem of multi-drug resistance is becoming a major concern for clinicians. In addition, a repertoire of antifungal agents is far less in number than antibacterial drugs. To combat these problems, combination therapy has gained a lot of interest. We previously reported the synergistic interaction of some mono- and bis-dihydropyrimidinone and thione derivatives with fluconazole and amphotericin B for combination antifungal therapy...
December 1, 2017: MedChemComm
H M Manukumar, B Chandrasekhar, K P Rakesh, A P Ananda, M Nandhini, P Lalitha, S Sumathi, Hua-Li Qin, S Umesha
Staphylococcus aureus is a commonly found pathogen that can cause food-spoilage and life threatening infections. However, the potential molecular effects of natural active thymol molecules and chitosan silver nanoparticles (C@AgNPs) in bacteria remain unclear. This gap in the literature has prompted us to study the effects of thymol loaded chitosan silver nanoparticles (T-C@AgNPs) against biofilm associated proteins in methicillin-resistant S. aureus (Bap-MRSA) 090 and also their toxicity, anti-cancer activity, and validation of their in silico molecular docking...
December 1, 2017: MedChemComm
Yu-Ting Wang, Yan Fang, Meng Zhao, Ming-Xue Li, Yu-Mei Ji, Qiu-Xia Han
In this paper, synthesis and characterization of metal complexes [Cu2 (L)3 ]ClO4 ( 1 ), [Ga(L)2 ]NO3 ·2H2 O ( 2 ) and [In(L)2 ]NO3 ·H2 O ( 3 ) (HL = 2-acetylpyridine N (4)-phenylthiosemicarbazone) was carried out, including elemental analysis, spectral analysis (IR, UV-vis, NMR), and X-ray crystallography. Complex 1 contains one S-bridged binuclear [Cu2 (L)3 ]+ unit, where two Cu atoms display diverse coordination geometries: one being square planar geometry and the other octahedral geometry. Both 2 and 3 are mononuclear complexes, and the metal centers in 2 and 3 are chelated by two NNS tridentate ligands possessing a distorted octahedral geometry...
November 1, 2017: MedChemComm
Rong Wang, Shuang Hou, Xiaojing Dong, Daijie Chen, Lei Shao, Liujia Qian, Zhong Li, Xiaoyong Xu
A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712). Some of the synthesized compounds exhibited synergistic activity. When 4 μg ml-1 compound B1 was combined with PB, it showed potent antibacterial activity, achieving 64-fold reduction of the MIC of PB. Furthermore, compound B1 showed prominent synergistic efficacy in both concentration gradient and time-kill curves in vitro ...
November 1, 2017: MedChemComm
Ning Sun, Yuan-Yuan Zheng, Ruo-Lan Du, Sen-Yuan Cai, Kun Zhang, Lok-Yan So, Kwan-Choi Cheung, Chao Zhuo, Yu-Jing Lu, Kwok-Yin Wong
The filamenting temperature-sensitive mutant Z (FtsZ) protein is generally recognized as a promising antimicrobial drug target. In the present study, a small organic molecule (tiplaxtinin) was identified for the first time as an excellent cell division inhibitor by using a cell-based screening approach from a library with 250 compounds. Tiplaxtinin possesses potent antibacterial activity against Gram-positive pathogens. Both in vitro and in vivo results reveal that the compound is able to disrupt dynamic assembly of FtsZ and Z-ring formation effectively through the mechanism of stimulating FtsZ polymerization and impairing GTPase activity...
October 1, 2017: MedChemComm
Shanmugapriya Perumal, Roziahanim Mahmud, Nornisah Mohamed
Pseudomonas aeruginosa is naturally resistant to many classes of antipseudomonal antibiotics due to the species ability to easily acquire resistance. Plant-based antibacterial agent in combination with the existing antibiotic proposes an alternative treatment regimen for the eradication of resistant bacterial infections. The antibacterial effects of the isolated epicatechin 3-gallate compound from Euphorbia hirta in combination with cefepime were investigated in vitro against resistant P. aeruginosa . The fractional inhibitory concentration index of the combination was determined using checkerboard broth microdilution method...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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