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Antibacterial Effect

Selvaraj Arokiyaraj, Rajaraman Bharanidharan, Paul Agastian, Hakdong Shin
BACKGROUND: In the present study, hexane: methanol (50:50) leaf extract of Marisela minuta has been evaluated for its chemical composition, antioxidant effect and the antimicrobial mechanism of action against food borne pathogenic bacteria. RESULTS: The phytochemical evaluation of extract by GC/MS revealed the major abundance of benzoic acid-4-ethoxyethyl ester (43.39%) and farnesol acetate (18.42%). The extract exhibited potential antioxidant and free radical scavenging properties with promising antibacterial activities against the test pathogens with Pseudomonas aeruginosa being the most susceptible with maximum inhibition zone (17 mm) and IC50 value of 125 µg, respectively...
October 20, 2018: Chemistry Central Journal
Weixi Gao, Yan He, Fengli Li, Chenwei Chai, Jinwen Zhang, Jieru Guo, Chunmei Chen, Jianping Wang, Hucheng Zhu, Zhengxi Hu, Yonghui Zhang
By feeding 1-methyl-l-tryptophan (1-MT) into cultures of the arthropod-associated fungus Chaetomium globosum TW1-1, three novel cytochalasan alkaloids, termed as armochaetoglosins A-C (1-3), together with five known analogues, namely prochaetoglobosin I (4), chaetoglobosin T (5), chaetoglobosin C (6), armochaetoglobin Y (7), and chaetoglobosin Vb (8), were isolated and characterized. Their structures including absolute configurations were elucidated by means of NMR spectroscopy, single-crystal X-ray crystallography, and comparison of the experimental electronic circular dichroism (ECD) spectra...
October 10, 2018: Bioorganic Chemistry
Rohit Tripathi, Aadesh Narayan, Indrajit Bramhecha, Javed Sheikh
Linen fabric lacks functional properties which can be imparted using CeO2 nanoparticles; however, the efficiency and durability against the repeated washing is always a big limitation. Wash-durable functionalization thus can be achieved by surface modification using chitosan-based recipes which can also impart additional functional properties to linen. In the present work, the modification of linen fabric was achieved using a chitosan-based recipe followed by in-situ synthesis of CeO2 nanoparticles on chitosan-treated fabrics...
October 18, 2018: International Journal of Biological Macromolecules
Ya-Ping Gou, Ji-Yao Li, Mohamed M Meghil, Christopher W Cutler, Hockin H K Xu, Franklin R Tay, Li-Na Niu
OBJECTIVE: Secondary caries and degradation of hybrid layers are two major challenges in achieving durable resin-dentin bonds. The objectives of the present study were to investigate the effects of a 2% quaternary ammonium silane (QAS) cavity cleanser on bacteria impregnated into dentin blocks and the gelatinolytic activity of the hybrid layers. METHODS: Microtensile bond strength was first performed to evaluate if the 2% QAS cavity cleanser adversely affected bond strength...
October 17, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Jun Wang, Ningning Huang, Jia Xiong, Hongkui Wei, Siwen Jiang, Jian Peng
The intestinal epithelial barrier plays a critical role in the etiopathogenesis of ulcerative colitis. This study aims to explore the potential effects and underlying mechanisms of medium chain fatty acids (caprylic acid and nonanoic acid) on intestinal epithelial barrier function. Using the porcine jejunal epithelial cell line IPEC-J2, a well-established model, challenged with Escherichia coli ATCC 43889 (O157:H7), we found that treatment with caprylic acid (C8) and nonanoic acid (C9) significantly reduced bacterial translocation, enhanced antibacterial activity, and remarkably increased the secretion of porcine β-defensins 1 (pBD-1) and pBD-2...
October 17, 2018: International Immunopharmacology
Jinlong Shao, Bing Wang, Carla J M Bartels, Ewald M Bronkhorst, John A Jansen, X Frank Walboomers, Fang Yang
Various strategies have been explored to prevent pin tract infections (PTI), including the use of antibacterial sleeves. However, an ideal animal model to evaluate the efficacy of antibacterial strategies is still lacking. This study aimed to construct an animal model with a consistent induction of infection after bacterial challenge. Further, the efficacy of silver and chlorhexidine loaded chitosan sleeves was evaluated to prevent PTI around a percutaneous implant. Titanium pins wrapped with sleeves were implanted in anterior lateral rabbit tibia...
October 17, 2018: Acta Biomaterialia
En Hyung Chang, Joanne Huang, Zixiang Lin, Angela C Brown
BACKGROUND: Catechins, polyphenols derived from tea leaves, have been shown to have antibacterial properties, through direct killing of bacteria as well as through inhibition of bacterial toxin activity. In particular, certain catechins have been shown to have bactericidal effects on the oral bacterium, Aggregatibacter actinomycetemcomitans, as well as the ability to inhibit a key virulence factor of this organism, leukotoxin (LtxA). The mechanism of catechin-mediated inhibition of LtxA has not been shown...
October 17, 2018: Biochimica et biophysica acta. General subjects
Parisa Parsa, Azin Paydayesh, Seyed Mohammad Davachi
Hydrogels have been used in many biomedical applications such as drug delivery and tissue engineering in recent decades. To improve the physiochemical and antimicrobial properties of these hydrogels and developing their applications, hybrid systems consisting of hydrogels, biodegradable nanoparticles and antibiotics were synthesized. In this regard, nanocomposite hydrogels based on PVA, 5% chitosan nanoparticles (NC) and various contents of tetracycline were prepared using freezing-thawing cycles and characterized using Fourier transform infrared spectroscopy (FTIR), gel fraction, swelling, antibacterial and cell viability studies, contact angle measurements, scanning electron microscopy, hydrolytic degradation and release studies...
October 17, 2018: International Journal of Biological Macromolecules
Diana Silva, Hermínio C de Sousa, Maria Helena Gil, Luís F Santos, Guilhermina Martins Moutinho, Ana Paula Serro, Benilde Saramago
In this study we investigated the possibility of using polyelectrolytes with antibacterial properties to form layer-by-layer (LbL) coatings on contact lens materials with the objective of controlling the release of ophthalmic drugs, while minimizing bacterial growth. A silicone-based hydrogel recently proposed by our group was chosen as a drug releasing soft contact lens (SCL) material and three drugs were tested: moxifloxacin hydrochloride (MXF), chlorhexidine diacetate monohydrate (CHX), and diclofenac sodium salt (DIC)...
October 17, 2018: International Journal of Pharmaceutics
Kai Chen, Yu Yuan, Ziyi Wang, Dezhi Song, Jinmin Zhao, Zhen Cao, Junhao Chen, Qiang Guo, Li Chen, Jennifer Tickner, Jiake Xu
Excessive osteoclast formation and function are considered as the main causes of bone lytic disorders such as osteoporosis and osteolysis. Therefore, the osteoclast is a potential therapeutic target for the treatment of osteoporosis or other osteoclast-related diseases. Helvolic acid (HA), a mycotoxin originally isolated from Aspergillus fumigatus , has been discovered as an effective broad-spectrum antibacterial agent and has a wide range of pharmacological properties. Herein, for the first time, HA was demonstrated to be capable of significantly inhibiting receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and bone resorption in vitro by suppressing nuclear factor of activated T cells 1 (NFATc1) activation...
October 20, 2018: Journal of Cellular Physiology
Wentao Jiang, Yufei Wang, Junyuan Luo, Xinwei Li, Xuedong Zhou, Wei Li, Linglin Zhang
Dental caries is a biofilm-mediated disease that occurs when acidogenic/aciduric bacteria obtain an ecological advantage over commensal species. In previous studies, the effects of the antimicrobial peptide GH12 on planktonic bacteria and monospecies biofilms were confirmed. The objectives of this study were to investigate the effects of GH12 on a cariogenic multispecies biofilm and to preliminarily explain the mechanism. In this biofilm model, Streptococcus mutans ATCC 70061 was the representative of cariogenic bacteria, while Streptococcus gordonii ATCC 35105 and Streptococcus sanguinis JCM 5708 were selected as healthy microbiota...
October 19, 2018: Applied and Environmental Microbiology
P Chastagner, D Michel, A Contet, A Lozniewski, T Hadou, C Schmitt, A Phulpin, F Fouyssac, L Mansuy
BACKGROUND: Infection is the major cause of treatment-related mortality in childhood acute leukemia, mainly due to bacterial translocation across the intestinal mucosa. Only a few studies have reported the impact of different antibacterial prophylaxis treatments on digestive tract flora and infection-related mortality. PROCEDURES: We performed a retrospective analysis of two different digestive tract decontamination modalities (selective or total digestive decontamination) in a large single-center series of 323 children during the induction treatment of acute leukemia between January 1995 and December 2014...
October 16, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Nguyen Cong Minh, Van Hoa Nguyen, Simona Schwarz, Willem F Stevens, Trang Si Trung
In this study, low molecular weight chitosan salt (LMWC-HCl) highly soluble in water was prepared from low molecular weight chitosan (LMWC) in the solid state exposed to hydrogen chloride gas as a reagent. The effects of chitosan particle size, exposure conditions, reaction temperature and reaction time were investigated on the solubility and the molecular weight of obtained products. The formation of the chloride salt was observed after 3 h in a range of temperatures from 4 to 50 °C. The solubility of prepared LMWC-HCl was over 98% for all samples, much higher than that of the original LMWC...
October 16, 2018: International Journal of Biological Macromolecules
Xiunan Jiang, Yiting Shen, Haixing Wang, Caihong Wang, Xiaoxia Ye, Zheng Xiang
Kaurenoic acid (KA), a kaurane diterpene found in several medicinal plants, is an active ingredient with potential anti-inflammatory, anticonvulsant, antibacterial and antitumor activities. In this work, an ultra-performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) was firstly developed and validated to quantify kaurenoic acid in rat plasma. Rhein was chosen as the internal standard (IS) and the plasma was processed with one-step acetonitrile protein precipitation; the chromatographic separation was achieved on a HSS T3 (2...
October 9, 2018: Journal of Pharmaceutical and Biomedical Analysis
Ge Gao, Yao-Wen Jiang, Hao-Ran Jia, Fu-Gen Wu
A near-infrared (NIR) light-triggerable thermo-sensitive hydrogel-based drug reservoir that can realize on-demand antibiotics release and hyperthermia-assisted bacterial inactivation was prepared to combat bacterial infection and promote wound healing. The drug reservoir was fabricated by mixing ciprofloxacin (Cip, a potent antibiotic)-loaded polydopamine (PDA) nanoparticles (NPs) and glycol chitosan (GC) to form an injectable hydrogel (PDA NP-Cip/GC hydrogel, abbreviated as Gel-Cip). On the one hand, the positive charge of GC and the adsorbability of PDA NPs made bacteria be readily trapped on the surface of Gel-Cip...
October 2, 2018: Biomaterials
Andreas Schinkovitz, Pierre Le Pogam, Séverine Derbré, Emilie Vessieres, Patricia Blanchard, Sangeetha-Laura Thirumaran, Dimitri Breard, Marie-Chistine Aumond, Martin Zehl, Ernst Urban, Amandeep Kaur, Nathalie Jäger, Stefanie Hofer, Brigitte Kopp, Hermann Stuppner, Isabelle Baglin, Denis Seraphin, Sophie Tomasi, Daniel Henrion, Joël Boustie, Pascal Richomme
Secondary metabolites from lichens are known for exhibiting various biological effects such as anti-inflammatory, antioxidant and antibacterial activities. Despite this wide range of reported biological effects, their impact on the formation of advanced glycation end products (AGEs) remains vastly unexplored. The latter are known contributors to lifestyle and age-related diseases such as Alzheimer and Parkinson. Moreover, the development of atherosclerosis and arterial stiffness is causally linked to the formation of AGEs...
October 16, 2018: Fitoterapia
Sawssen Hajji, Sameh Ben Khedir, Ibtissem Hamza-Mnif, Marwa Hamdi, Ines Jedidi, Rim Kallel, Sami Boufi, Moncef Nasri
The aim of the present study was to prepare chitosan-PVA‑silver nanoparticles (CS-AgNPs) through green method. Chitosan and PVA polymers acted as stabilizing agents. DLS and TEM analyses showed that CS-AgNPs were homogeneously dispersed in matrix with an average size of 190-200 nm. The CS-AgNPs were tested for their antioxidant and antibacterial properties and the results revealed that they exhibited higher antioxidant activity than CS powder. Moreover, CS-AgNPs were characterized by a low cytotoxicity effect at 5-200 μg/ml against Chinese Hamster Ovary (CHO-K1) cells...
October 16, 2018: Biochimica et biophysica acta. General subjects
Oihana Basabe-Burgos, Jakub Zebialowicz, Guido Stichtenoth, Tore Curstedt, Peter Bergman, Jan Johansson, Anna Rising
BACKGROUND: Pulmonary surfactant spreads rapidly over the airway epithelium, a property that could be harnessed to transport drugs into the lungs. For efficient drug delivery, an interaction between pulmonary surfactant and the drug to be administered is likely needed. On the other hand, the interaction should not compromise the activity of surfactant or the drug once delivered in vivo. The antibiotics gentamicin (an aminoglycoside) and polymyxin E represent drugs that could benefit from being delivered directly to the lung, thereby increasing local concentrations and reducing systemic side effects...
October 19, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Xian Chen, Cheng Sun, Pedro Laborda, Yancun Zhao, Ian Palmer, Zheng Qing Fu, Jingping Qiu, Fengquan Liu
Xanthomonas oryzae pv. oryzae ( Xoo ) causes rice bacterial blight (BB), one of the most widespread and destructive diseases in rice-growing regions worldwide. Melatonin enhances pathogen resistance by inducing plant innate immunity, but the direct effect of melatonin on plant pathogenic bacteria is poorly understood. In this study, we investigated the direct effects of melatonin on Xoo . Exogenous melatonin at 200 μg/mL significantly inhibited the proliferation of Xoo and reduced the mRNA expression of five genes involved in cell division...
2018: Frontiers in Microbiology
Bo Qiu, Xiong-Feng Xu, Rong-Hui Deng, Gan-Qing Xia, Xi-Fu Shang, Pang-Hu Zhou
In the present work, flexible chitosan/ZnO nanocomposite films were prepared by a green and facile method through in situ precipitation of nano-ZnO (nZnO) in the chitosan film. Zn(Ac)2 was added in chitosan solution to provide Zn2+ , thus Zn2+ was fixed in the chitosan matrix and converted into nZnO through interaction with NaOH with heating. The structure and properties of the hybrid films were characterized by Field emission scanning electron microscope (FESEM), atomic force microscope (AFM), Fourier transform infra-red (FT-IR), X-ray diffraction (XRD) and tensile testing...
October 15, 2018: International Journal of Biological Macromolecules
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