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https://www.readbyqxmd.com/read/29144589/-sphingosine-1-phosphate-immobilized-on-nanotopographical-scaffolds-improve-myogenic-differentiation
#1
Min Suk Lee, Hee Seok Yang
The skeletal muscle consists of highly aligned dense cables of collagen fibers with nanometer feature size to support muscle fibers. The skeletal myocyte can be greatly affected to differentiate by their surrounding topographical structure. To improve myogenic differentiation, we fabricated cell culture platform that sphingosine-1-phosphate (S1P) which regulated myocyte behavior was immobilized on a biomimetic nanopatterned polyurethaneacrylate (PUA) substrate using 3,4-dihydroxyphenylalanine (L-DOPA) for providing topographical and biological cues synergistically...
November 16, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29129019/genetic-characterization-of-bank-vole-virus-bavv-a-new-paramyxovirus-isolated-from-kidneys-of-bank-voles-in-russia
#2
Sergey Alkhovsky, Alexander Butenko, Aykaz Eremyan, Alexey Shchetinin
A genome of bank vole virus (BaVV), isolated from kidney tissues of bank voles (Myodes glareolus) in Russia in 1973, was sequenced. The genomic organization of BaVV (3'-N-P/V/C-M-F-G-L-5', 16,992 nt in length; GenBank accession number MF943130) is most similar to that of Mossman virus (MoV) and Nariva virus (NarPV), two ungrouped paramyxoviruses isolated from rodents in Australia and Trinidad, respectively. The proteins of BaVV have the highest level of sequence identity (ranging from 23-28% for G protein to 66-73% for M protein) to proteins of MoV and NarPV...
November 11, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29127356/a-transcriptomic-study-of-myogenic-differentiation-under-the-overexpression-of-ppar%C3%AE-by-rna-seq
#3
Kan He, Guoying Wu, Wen-Xing Li, Daogang Guan, Wenwen Lv, Mengting Gong, Shoudong Ye, Aiping Lu
To study the cellular and molecular function of peroxisome proliferator-activated receptor γ (PPARγ) in skeletal muscle differentiation, we have generated inducible gain-of-function to overexpress PPARγ in C2C12 myoblasts. In order to identify PPARγ targets, RNA sequencing (RNA-seq) was used to evaluate and quantify the transcriptomes and expression patterns during myogenic differentiation under the overexpression of PPARγ. The formation of myotubes and the expression of muscle-specific myogenic genes such as MyoD and MyoG may be inhibited by PPARγ overexpression...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127046/function-of-the-myogenic-regulatory-factors-myf5-myod-myogenin-and-mrf4-in-skeletal-muscle-satellite-cells-and-regenerative-myogenesis
#4
REVIEW
Peter S Zammit
Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal myogenic lineage and control of muscle differentiation during development. These factors are also involved in specification of the muscle satellite cell lineage, which becomes the resident stem cell compartment in adult skeletal muscle. While MYF5, MYOD, Myogenin and MRF4 have subtle roles in mature muscle, they again play a crucial role in directing satellite cell function to regenerate skeletal muscle: linking the genetic control of developmental and regenerative myogenesis...
November 7, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29127045/the-myogenic-regulatory-factors-determinants-of-muscle-development-cell-identity-and-regeneration
#5
REVIEW
J Manuel Hernández-Hernández, Estela G García-González, Caroline E Brun, Michael A Rudnicki
The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis. The dynamics of their temporal and spatial expression as well as their biochemical properties have allowed the identification of a precise and hierarchical relationship between the four MRFs. This relationship establishes the myogenic lineage as well as the maintenance of the terminal myogenic phenotype...
November 7, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29125995/a-human-ips-cell-myogenic-differentiation-system-permitting-high-throughput-drug-screening
#6
Tomoya Uchimura, Jun Otomo, Masae Sato, Hidetoshi Sakurai
Muscular dystrophy is a disease characterized by progressive muscle weakness and degeneration. There are currently no available treatments for most muscular diseases, such as muscular dystrophy. Moreover, current therapeutics are focused on improving the quality of life of patients by relieving the symptoms or stress caused by the disease. Although the causative genes for many muscular diseases have been identified, the mechanisms underlying their pathogenesis remain unclear. Patient-derived induced pluripotent stem cells (iPSCs) have become a powerful tool for understanding the pathogenesis of intractable diseases, as well as for phenotype screening, which can serve as the basis for developing new drugs...
October 28, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29108230/apigenin-enhances-skeletal-muscle-hypertrophy-and-myoblast-differentiation-by-regulating-prmt7
#7
Young Jin Jang, Hyo Jeong Son, Yong Min Choi, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha
Apigenin, a natural flavone abundant in various plant-derived foods including parsley and celery, has been shown to prevent inflammation and inflammatory diseases. However, the effect of apigenin on skeletal muscle hypertrophy and myogenic differentiation has not previously been elucidated. Here, we investigated the effects of apigenin on quadricep muscle weight and running distance using C57BL/6 mice on an accelerating treadmill. Apigenin stimulated mRNA expression of MHC (myosin heavy chain) 1, MHC2A, and MHC2B in the quadricep muscles of these animals...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100953/dietary-methionine-restriction-effects-on-glucose-tolerance-lipid-content-and-micro-rna-composition-in-the-muscle-of-rainbow-trout
#8
M N Latimer, B M Cleveland, P R Biga
Lean muscle mass plays an important role in overall health, as altered skeletal muscle metabolism can impact both the incidence and prevention of conditions related to metabolic health. Intriguingly, dietary methionine restriction (MR) has been shown to ameliorate this phenotype over time potentially through mechanisms related to changes in myogenic precursor cell (MPC) differentiation status. Recently the role of micro-RNAs (miRs) in regulating the expression of muscle specific transcription factors myoD and myogenin as well as signaling molecules involved in skeletal muscle differentiation has been reported in vitro...
October 31, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29097153/finding-myod-and-lessons-learned-along-the-way
#9
REVIEW
Andrew B Lassar
In 1987, Robert Davis, Hal Weintraub and I reported the identification of MyoD, a transcription factor that could reprogram fibroblasts into skeletal muscle cells. In this recollection, I both summarize the prior work of Helen Blau, Woody Wright, Peter Jones and Charlie Emerson that inspired my entry into this field, and the subsequent events that led to finding MyoD. Lastly, I highlight some of the principles in developmental biology that have emerged during the past 30 years, which are particularly relevant to skeletal muscle biology...
November 1, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29080996/impact-of-local-heating-and-cooling-on-skeletal-muscle-transcriptional-response-related-to-myogenesis-and-proteolysis
#10
Roksana B Zak, B M Hassenstab, L K Zuehlke, M W S Heesch, R J Shute, T L Laursen, D T LaSalle, D R Slivka
PURPOSE: To determine the impact of local muscle heating and cooling on myogenic and proteolytic gene responses following resistance exercise. METHODS: Recreationally trained males (n = 12), age 25.3 ± 1.5, % body fat 13.6 ± 1.92, completed four sets of 8-12 repetitions of unilateral leg press and leg extension while heating one leg, and cooling the other. Muscle biopsies were taken from the vastus lateralis of each leg pre and 4 h post exercise. RESULTS: MyoD, FOXO1, and MuRF1 mRNA increased with exercise regardless of temperature (p < 0...
October 28, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29079444/temporal-regulation-of-chromatin-during-myoblast-differentiation
#11
REVIEW
Akihito Harada, Yasuyuki Ohkawa, Anthony N Imbalzano
The commitment to and execution of differentiation programmes involves a significant change in gene expression in the precursor cell to facilitate development of the mature cell type. In addition to being regulated by lineage-determining and auxiliary transcription factors that drive these changes, the structural status of the chromatin has a considerable impact on the transcriptional competence of differentiation-specific genes, which is clearly demonstrated by the large number of cofactors and the extraordinary complex mechanisms by which these genes become activated...
October 28, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29079088/seasonal-shift-of-diet-in-bank-voles-explains-trophic-fate-of-anthropogenic-osmium
#12
Frauke Ecke, Åsa M M Berglund, Ilia Rodushkin, Emma Engström, Nicola Pallavicini, Dieke Sörlin, Erik Nyholm, Birger Hörnfeldt
Diet shifts are common in mammals and birds, but little is known about how such shifts along the food web affect contaminant exposure. Voles are staple food for many mammalian and avian predators. There is therefore a risk of transfer of contaminants accumulated in voles within the food chain. Osmium is one of the rarest earth elements with osmium tetroxide (OsO4) as the most toxic vapor-phase airborne contaminant. Anthropogenic OsO4 accumulates in fruticose lichens that are important winter food of bank voles (Myodes glareolus)...
October 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29073096/staufen1-inhibits-myod-translation-to-actively-maintain-muscle-stem-cell-quiescence
#13
Antoine de Morrée, Cindy T J van Velthoven, Qiang Gan, Jayesh S Salvi, Julian D D Klein, Igor Akimenko, Marco Quarta, Stefano Biressi, Thomas A Rando
Tissue regeneration depends on the timely activation of adult stem cells. In skeletal muscle, the adult stem cells maintain a quiescent state and proliferate upon injury. We show that muscle stem cells (MuSCs) use direct translational repression to maintain the quiescent state. High-resolution single-molecule and single-cell analyses demonstrate that quiescent MuSCs express high levels of Myogenic Differentiation 1 (MyoD) transcript in vivo, whereas MyoD protein is absent. RNA pulldowns and costainings show that MyoD mRNA interacts with Staufen1, a potent regulator of mRNA localization, translation, and stability...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29071380/satellite-cell-response-to-concurrent-resistance-exercise-and-high-intensity-interval-training-in-sedentary-overweight-obese-middle-aged-individuals
#14
Jamie K Pugh, Steve H Faulkner, Mark C Turner, Myra A Nimmo
PURPOSE: Sarcopenia can begin from the 4-5th decade of life and is exacerbated by obesity and inactivity. A combination of resistance exercise (RE) and endurance exercise is recommended to combat rising obesity and inactivity levels. However, work continues to elucidate whether interference in adaptive outcomes occur when RE and endurance exercise are performed concurrently. This study examined whether a single bout of concurrent RE and high-intensity interval training (HIIT) alters the satellite cell response following exercise compared to RE alone...
October 25, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29069832/acylated-and-unacylated-ghrelin-inhibit-atrophy-in-myotubes-co-cultured-with-colon-carcinoma-cells
#15
Xianliang Zeng, Sizeng Chen, Yang Yang, Zhao Ke
Cancer cachexia is a result of increased protein degradation and decreased protein synthesis. The multifunctional circulating hormone ghrelin promotes synthesis and inhibits degradation of muscle protein, but its mechanism of action is not fully understood. Here, we investigated whether co-culturing C2C12 myotubes with CT26 colon carcinoma cells induces myotube atrophy, and whether acylated ghrelin (AG) and unacylated ghrelin (UnAG) had anti-atrophic effects. We found that co-culture induced myotube atrophy and increased tumor necrosis factor-alpha (TNF-α) and myostatin concentrations in the culture medium...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29051115/an-herbal-formula-consisting-of-schisandra-chinensis-turcz-baill-lycium-chinense-mill-and-eucommia-ulmoides-oliv-alleviates-disuse-muscle-atrophy-in-rats
#16
Seongguk Cho, Riwon Hong, Poorm Yim, Mijung Yeom, Bombi Lee, Woong Mo Yang, Jongki Hong, Hyang Sook Lee, Dae-Hyun Hahm
ETHNOPHARMACOLOGICAL RELEVANCE: Schisandra chinensis (Turcz.) Baill (SC), Lycium chinense Mill (LC) and Eucommia ulmoides Oliv (EU) are representative tonic herbal medicines that help to strengthen body muscles and bones making them stronger according to the Donguibogam, a tradition medical book of the Joseon Dynasty in Korea. AIM OF STUDY: To evaluate effects of an herbal formula consisting of SC, LC and EU on muscle atrophy in C2C12 myotubes and in a rat model of immobilization-induced muscle atrophy...
October 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29044517/circfut10-reduces-proliferation-and-facilitates-differentiation-of-myoblasts-by-sponging-mir-133a
#17
Hui Li, Jiameng Yang, Xuefeng Wei, Chengchuang Song, Dong Dong, Yongzhen Huang, Xianyong Lan, Martin Plath, Chuzhao Lei, Yun Ma, Xinglei Qi, Yueyu Bai, Hong Chen
Circular RNAs (circRNAs) have been identified in various tissues and cell types from human, monkey, porcine and mouse. However, knowledge on circRNAs in bovine muscle development is limited. We downloaded and analyzed the circRNAs sequencing data of bovine skeletal muscle tissue, and further characterized the role of a candidate circRNA (circFUT10) in muscle development. Quantitative real-time PCR (qPCR) and western blot assays were used to confirm the expression of genes involved in myoblasts differentiation and proliferation...
October 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29036192/viral-infection-upregulates-myostatin-promoter-activity-in-orange-spotted-grouper-epinephelus-coioides
#18
Yi-Tien Chen, Chao-Fen Lin, Young-Mao Chen, Chih-En Lo, Wan-Erh Chen, Tzong-Yueh Chen
Myostatin is a negative regulator of myogenesis and has been suggested to be an important factor in the development of muscle wasting during viral infection. The objective of this study was to characterize the main regulatory element of the grouper myostatin promoter and to study changes in promoter activity due to viral stimulation. In vitro and in vivo experiments indicated that the E-box E6 is a positive cis-and trans-regulation motif, and an essential binding site for MyoD. In contrast, the E-box E5 is a dominant negative cis-regulatory...
2017: PloS One
https://www.readbyqxmd.com/read/29021711/ginsenoside-rg1-from-panax-ginseng-enhances-myoblast-differentiation-and-myotube-growth
#19
Ga-Yeon Go, Sang-Jin Lee, Ayoung Jo, Jaecheol Lee, Dong-Wan Seo, Jong-Sun Kang, Si-Kwan Kim, Su-Nam Kim, Yong Kee Kim, Gyu-Un Bae
BACKGROUND: Ginsenoside Rg1 belongs to protopanaxatriol-type ginsenosides and has diverse pharmacological activities. In this report, we investigated whether Rg1 could upregulate muscular stem cell differentiation and muscle growth. METHODS: C2C12 myoblasts, MyoD-transfected 10T1/2 embryonic fibroblasts, and HEK293T cells were treated with Rg1 and differentiated for 2 d, subjected to immunoblotting, immunocytochemistry, or immunoprecipitation. RESULTS: Rg1 activated promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promote the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29019255/expression-profiles-and-associations-of-muscle-regulatory-factor-mrf-genes-with-growth-traits-in-tibetan-chickens
#20
Runfeng Zhang, Rui-Wen Li, Lifeng Zhi, Ya-Ou Xu, Ya Qiu Lin, Lianhong Chen
1. Muscle regulatory factors (MRFs), including Myf5, Myf6 (MRF4/herculin), MyoD, and MyoG (myogenin), play pivotal roles in muscle growth and development. Therefore, they are considered as candidate genes for meat production traits in livestock and poultry. 2. The objective of this study was to investigate the expression profiles of these genes in skeletal muscles (breast muscle and thigh muscle) at 5 developmental stages (0, 81, 119, 154, and 210 d old) of Tibetan chickens. Relationships between expressions of these genes and growth and carcass traits in these chickens were also estimated...
October 11, 2017: British Poultry Science
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