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Sadeq Ali Al-Maweri, Sajna Ashraf, Amara Swapna Lingam, Ahmed Alqutaibi, Saleem Abdulrab, Nader Alaizari, Esam Halboub
The management of oral submucous fibrosis (OSF) is quite challenging, and as yet, no effective therapy is available for its management. The present systematic review and meta-analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF. A comprehensive search in Pubmed/Medline, Scopus, and Web of Science databases was conducted to identify the relevant randomized clinical trials. RevMan 5.3 software was used for data analysis. Six randomized controlled trials fulfilled the inclusion criteria...
October 17, 2018: Journal of Oral Pathology & Medicine
Rafael Bayarri-Olmos, Nikolaj Kirketerp-Moller, Laura Pérez-Alós, Karsten Skjodt, Mikkel-Ole Skjoedt, Peter Garred
Collectin-11 (CL-11) is a pattern recognition molecule of the lectin pathway of complement with diverse functions spanning from host defense to embryonic development. CL-11 is found in the circulation in heterocomplexes with the homologous collectin-10 (CL-10). Abnormal CL-11 plasma levels are associated with the presence of disseminated intravascular coagulation, urinary schistosomiasis, and congenital disorders. Although there has been a marked development in the characterization of CL-11 there is still a scarcity of clinical tools for its analysis...
2018: Frontiers in Immunology
Wiesław Kurzątkowski, Ümit Kartoğlu, Paulina Górska, Małgorzata Główka, Katarzyna Woźnica, Aleksandra A Zasada, Grażyna Szczepańska, Grzegorz Trykowski, Marianna Gniadek, Mikołaj Donten
Accidental freezing of aluminum-based vaccines occurs during their storage and transportation, in both developed and developing countries. Freezing damages the freeze-sensitive aluminum adjuvanted vaccines, through separation of lattice between aluminum adjuvant and antigen, leading to formation of aluminum aggregates, and loss of potency. In this study, we examined Alhydrogel™ ([AlO(OH)]xnH2 O, aluminum hydroxide, hydrated for adsorption) stored under recommended conditions, and exposed to freezing temperature until solid-frozen...
October 12, 2018: Vaccine
Zhenhong Sun, Cuilian Yu, Wei Wang, Guangfu Yu, Tingting Zhang, Lin Zhang, Jiguo Zhang, Kai Wei
Influenza A virus causes periodic outbreaks and seriously threatens human health. The drug-resistant mutants have shown an epidemic trend because of the abuse of chemical drugs. Aloe polysaccharides (APS) extracted from Aloe vera leaves have evident effects on the therapy of virus infection. However, the activity of APS in anti-influenza virus has yet to be investigated. Here, we refined polysaccharides from A. vera leaf. In vitro test revealed that APS could inhibit the replication of a H1N1 subtype influenza virus, and the most obvious inhibitory effect was observed in the viral adsorption period...
2018: Frontiers in Microbiology
Sara Castiglia, Aloe Adamini, Deborah Rustichelli, Laura Castello, Katia Mareschi, Giuseppe Pinnetta, Marco Leone, Alessandra Mandese, Ivana Ferrero, Giulia Mesiano, Franca Fagioli
Following publication of the original article [1], the authors reported that all of the authors' names were processed incorrectly so that their given and family names were interchanged. In this Correction the correct author names are shown. The original publication of this article has been corrected.
October 10, 2018: Journal of Translational Medicine
Marcela Silvina Rial, María Luján Scalise, Micaela López Alarcón, Mónica Inés Esteva, Jacqueline Búa, Alejandro Francisco Benatar, Nilda Graciela Prado, Adelina Rosa Riarte, Laura Edith Fichera
This study evaluated the effectiveness of low doses of benznidazole (BNZ) on continuous administration (BNZc), combined with allopurinol (ALO), in C57BL/6J and C3H/HeN mice infected with Trypanosoma cruzi Nicaragua strain and T. cruzi Sylvio-X10/4 clone. TcN-C57BL/6J was also treated with intermittent doses of BNZ (BNZit). The drug therapy started 3 months post infection (pi) in the chronic phase of mice with heart disease progression, followed-up at 6 months pi. TcN-C57BL/6J treated with BNZc was also monitored up to 12 months pi by serology and electrocardiogram...
October 10, 2018: Parasitology
William J Scheideler, Matthew W McPhail, Rajan Kumar, Jeremy Smith, Vivek Subramanian
Inorganic transparent metal oxides represent one of the highest performing material systems for thin-film flexible electronics. Integrating these materials with low-temperature processing and printing technologies could fuel the next generation of ubiquitous transparent devices. In this work, we investigate the integration of UV-annealing with inkjet printing, demonstrating how UV-annealing of high- k AlO x dielectrics facilitates the fabrication of high-performance InO x transistors at low processing temperatures and improves bias-stress stability of devices with all-printed dielectrics, semiconductors, and source/drain electrodes...
October 18, 2018: ACS Applied Materials & Interfaces
Azin Niazi, Vafa Baradaran Rahimi, Sina Soheili-Far, Nafiseh Askari, Pouria Rahmanian-Devin, Zahra Sanei-Far, Amirhossein Sahebkar, Hassan Rakhshandeh, Vahid Reza Askari
Averagely 80% to 90% of breastfeeding women experience the nipple pain and fissures. The important factor for successful breastfeeding is to treat this problem. This study has done as a review with the aim of analysis of the clinical trials in the field of the prevention and treatment of the nipple fissures and pain due to the importance of breastfeeding. For this purpose, the key words of sore, nipples, fissure, trauma, wound, prevention, treatment, therapeutics, therapy, clinical trial, breastfeeding and their Persian synonyms and all of their possible combinations were searched in the national databases: SID and Iran Medex and Magiran, and in the international databases: PubMed, Scopus, Medline, Science direct by May 2017...
September 2018: Journal of Pharmacopuncture
Dulce C Macias-Ceja, Dolores Ortiz-Masiá, Pedro Salvador, Laura Gisbert-Ferrándiz, Carlos Hernández, Martin Hausmann, Gerhard Rogler, Juan V Esplugues, Joaquín Hinojosa, Rafael Alós, Francisco Navarro, Jesus Cosin-Roger, Sara Calatayud, María D Barrachina
Succinate, an intermediate of the tricarboxylic acid cycle, is accumulated in inflamed areas and its signaling through succinate receptor (SUCNR1) regulates immune function. We analyze SUCNR1 expression in the intestine of Crohn's disease patients and its role in murine intestinal inflammation and fibrosis. We show that both serum and intestinal succinate levels and SUCNR1 expression in intestinal surgical resections were higher in CD patients than in controls. SUCNR1 co-localized with CD86, CD206, and α-SMA+ cells in human intestine and we found a positive and significant correlation between SUCNR1 and α-SMA expression...
October 2, 2018: Mucosal Immunology
Surovi Saikia, Manobjyoti Bordoloi, Rajeev Sarmah, Bhaskor Kolita
Hit, Lead & Candidate Discovery Plant-based antiviral therapy is the current need for holistic health care management, which can be achieved through screening of phytochemicals and designing of antiviral peptides. There exist certain host's factors which are directly involved for rapid viral replication causing worldwide pandemic. A total of 177 phytochemicals from Ocimum sanctum (L.), Tinospora cordifolia (Thunb.) Miers, Cinnamomum camphora (L.) J. Presl., Allium sativum (L.), Curcuma longa (L.), and Aloe vera (L...
October 1, 2018: Drug Development Research
Yu-Huan Zhao, Peng Liu
In this paper, we present an adaptive ship detection method for single-look complex synthetic aperture radar (SAR) images. First, noncircularity is analyzed and adopted in ship detection task; besides, similarity variance weighted information entropy (SVWIE) is proposed for clutter reduction and target enhancement. According to the analysis of scattering of SVWIE and noncircularity, SVWIE-noncircularity (SN) decomposition is developed. Based on the decomposition, two components, the high-noncircularity SVWIE amplitude ( h ) and the low-noncircularity SVWIE amplitude ( l ), are obtained...
September 30, 2018: Sensors
Somayeh Baghersad, S Hajir Bahrami, Marziyeh Ranjbar Mohammadi, Mohammad Reza Mohaddes Mojtahedi, Peiman Brouki Milan
Nowadays, aloe-vera (AV) is exploited extensively in nanofibrous structures for skin substitutes. However, the lack of electrospinnability and appropriate mechanical characteristics are the key limitations for this natural extract to be used in the form of nanofibrous mats. In this study, two commercially available biopolymers, gelatin (Gel) and poly(ε‑caprolactone) (PCL), were chosen to improve these issues and double-nozzle electrospinning technique was used to fabricate hybrid scaffold from Gel/AV blend and PCL solutions...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Juan Zhang, Lihua Guo, Quanwu Zhang, Kangdong Liu, Ziming Dong
Natural compounds which can block cell transformation due to potential for chemoprevention have received increased attention. The present study aimed to investigate whether aloe emodin, which is present in aloe latex or the roots of the Rheum palmatum L. are able to block epidermal growth factor (EGF)‑ and tissue plasminogen activator‑induced JB6 C141 cell transformation. The aloe emodin treatment was applied to the JB6 C141 cell neoplastic model. The toxicity of aloe emodin was determined. The present study detected the expression level of AKT serine/threonine kinase 1 (AKT), lysine‑tRNA ligase MSK1 (MSK1) and cyclin D1 using western blotting...
September 27, 2018: Molecular Medicine Reports
Davood Hekmatpou, Fatemeh Mehrabi, Kobra Rahzani, Atefeh Aminiyan
BACKGROUND: One of the most common orthopedic problems is the incidence of pressure ulcer followed by immobility. This study aimed to investigate the effect of Aloe Vera gel on the prevention of pressure ulcer in patients hospitalized in the orthopedic ward. METHOD: This study is a randomized, triple-blind clinical trial which was done on 80 purposefully selected patients in orthopedic ward in Arak town, Iran, 2016. Patients were randomly assigned into two intervention and control groups based on blocking sampling method...
September 29, 2018: BMC Complementary and Alternative Medicine
Khursheed Ali, Bilal Ahmed, Mohammad Saghir Khan, Javed Musarrat
Biogenic hematite (α-Fe2 O3 ) nanoparticles (NPs) of average size <10 nm were synthesized using green approach with Aloe vera extract (ALE). The aim of the study was to assess the protective effect of extracellular polymeric substances (EPS) against antibacterial and antibiofilm activities of ALE-α-Fe2 O3 NPs in normal EPS producers (pristine) and experimentally modified (low-EPS) Pseudomonas aeruginosa (P. aeruginosa) cells and the mechanism of cell killing. Formation of ALE-α-Fe2 O3 NPs has been validated by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and Fourier-transformed infrared spectroscopy (FTIR) analysis...
November 2018: Journal of Photochemistry and Photobiology. B, Biology
Isobel C Monotti, Stewart D Ryan, Chris A Preston
OBJECTIVE: To report the outcome of dogs treated with triple pelvic osteotomy (TPO) for dorsal luxation after total hip replacement (THR). STUDY DESIGN: Retrospective clinical case series. ANIMALS: Seventeen client-owned animals. METHODS: Medical records were searched at a single institution for dogs that had been treated with TPO for dorsal THR luxation. The angle of lateral opening (ALO), version angle (VA), and inclination angle (IA) were measured from radiographs after THR and TPO and corrected for pelvic rotation...
September 28, 2018: Veterinary Surgery: VS
C Verity Bennett, Sabine Maguire, Diane Nuttall, Daniel M Lindberg, Steven Moulton, Lalit Bajaj, Alison M Kemp, Stephen Mullen
INTRODUCTION: Appropriate first aid can reduce the morbidity of burns, however, there are considerable variations between international first aid recommendations. We aim to identify, and compare first aid practices in children who present to Emergency Departments (ED) with a burn. METHODS: A prospective cross-sectional study of 500 children (0-16 completed years) presenting with a burn to a paediatric ED in the UK (Cardiff) and the USA (Denver, Colorado), during 2015-2017...
September 25, 2018: Burns: Journal of the International Society for Burn Injuries
Eric Teplicki, Qianli Ma, David E Castillo, Mina Zarei, Adam P Hustad, Juan Chen, Jie Li
INTRODUCTION: Aloe vera is sometimes used as a folk remedy for minor wounds and burns, but its mechanisms of action in wound healing are unclear. OBJECTIVE: In this study, the authors evaluate the effects of A vera on wound healing. MATERIALS AND METHODS: In vitro analyses of cell proliferation and migration were conducted on normal human primary skin fibroblasts and keratinocytes in growth media with A vera solution and preservatives at various concentrations...
September 2018: Wounds: a Compendium of Clinical Research and Practice
Belén Fernández-Castilla, Ariel M Aloe, Lies Declercq, Laleh Jamshidi, Patrick Onghena, S Natasha Beretvas, Wim Van den Noortgate
The synthesis of standardized regression coefficients is still a controversial issue in the field of meta-analysis. The difficulty lies in the fact that the standardized regression coefficients belonging to regression models that include different sets of covariates do not represent the same parameter, and thus their direct combination is meaningless. In the present study, a new approach called concealed correlations meta-analysis is proposed that allows for using the common information that standardized regression coefficients from different regression models contain to improve the precision of a combined focal standardized regression coefficient estimate...
September 24, 2018: Behavior Research Methods
Surabhi Singh, Amlan Gupta, Bhuvanesh Gupta
Scar preventive dextran based bionanocomposite dressings containing aloe vera (AV) and manuka honey (MH) were developed as wound care devices. This work was a challenge to fabricate herbal dressing that promotes healing, which at the same time is biocompatible, non-toxic, biodegradable, and cost effective in terms of the simplicity of application in complex chronic wound situations. With this aim, we synthesized in-situ crosslinked dextran/nanosoy/glycerol/chitosan (DNG/Ch) nanocomposite membranes via solvent casting technique followed by subsequent addition of AV and MH to obtain DNG/Ch/AV and DNG/Ch/MH herbal dressings...
September 21, 2018: International Journal of Biological Macromolecules
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