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https://www.readbyqxmd.com/read/30499390/ionophores-as-potent-anti-malarials-a-miracle-in-the-making
#1
Hina Bharti, Aakriti Singal, Mohsin Raza, P C Ghosh, Alo Nag
Plasmodium has a complex life cycle that spans between mosquito and human. For survival and pathogenesis it banks upon dynamic alterations in ionic transport across organelle and plasma membrane. Being a fundamental contributor of crucial biological processes in parasite, ionic balance facilitates parasite invasion, augmentation and transmission. Past few decades have witnessed tremendous advancement in understanding the relevance of ionic transit in parasites. Perhaps, not surprisingly, disruption of ionic homeostasis was thought to be detrimental for parasite...
November 29, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/30488924/interface-engineering-for-a-stable-chemical-structure-of-oxidized-black-phosphorus-via-self-reduction-in-alo-x-atomic-layer-deposition
#2
Dae-Kyoung Kim, Jimin Chae, Seok-Bo Hong, Hanbum Park, Kwang-Sik Jeong, Hyun-Woo Park, Se-Ra Kwon, Kwun-Bum Chung, Mann-Ho Cho
We evaluated the change in the chemical structure between dielectrics (AlOx and HfOx) grown by atomic layer deposition (ALD) and oxidized black phosphorus (BP), as a function of air exposure time. Chemical and structural analyses of the oxidized phosphorus species (PxOy) were performed using atomic force microscopy, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, first-principles density functional theory calculations, and the electrical characteristics of field-effect transistors (FETs)...
November 29, 2018: Nanoscale
https://www.readbyqxmd.com/read/30482970/characterization-of-aloe-vera-chitosan-composite-films-and-their-use-for-reducing-the-disease-caused-by-fungi-in-papaya-maradol
#3
Keila Monzón-Ortega, Miguel Salvador-Figueroa, Didiana Gálvez-López, Raymundo Rosas-Quijano, Isidro Ovando-Medina, Alfredo Vázquez-Ovando
Composite films with Aloe vera (A), chitosan (Ch) and essential oils (EOs) were formulated. Six of the twelve combinations tested formed films: A70Ch30, A70Ch30-15, A60Ch40, A60Ch40-15, A50Ch50, and A50Ch50-15. The A60Ch40-15 film showed the best physicochemical characteristics as well as the greatest in vitro antifungal activity. Although the A90Ch10 and A80Ch20-15 mixtures did not form films, their solutions showed high antifungal activity in vitro. Based on multivariate analysis of the data, A60Ch40-15, A90Ch10 and A80Ch20-15 films were selected as coating treatments for papaya during storage at 30 ± 2 °C and 80% RH...
December 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/30480250/long-term-non-invasive-treatment-via-intranasal-administration-of-nerve-growth-factor-protects-the-human-brain-in-frontotemporal-dementia-associated-with-corticobasal-syndrome-a-pilot-study
#4
Alberto de Bellis, Massimo de Bellis, Luigi Aloe
Background: Nerve growth factor (NGF) is known for playing a critical protective role on a number of brain neurons in mammals, including humans. NGF can be delivered to the CNS via nasal route and has a neuroprotective action in case of neurodegenerative diseases. Objective: The aim of this study is to investigate for the first time whether purified NGF can play a neuroprotective role on human brain neurons affected by neurodegenerative diseases when administered via nasal route...
March 31, 2018: JAD Reports
https://www.readbyqxmd.com/read/30472593/infrared-and-raman-spectroscopic-studies-of-mn-2-ions-doped-in-strontium-alumino-borate-glasses-describes-the-role-of-al-2-o-3
#5
Mohamad Raheem Ahmed, B Ashok, Shaik Kareem Ahmmad, Abdul Hameed, M Narasimha Chary, Md Shareefuddin
Strontium alumino borate glasses doped with Mn2+ ions (SABM) have been prepared and characterized by XRD, density, Electron paramagnetic resonance (EPR), FT-IR and Raman to investigate the spectral and physical properties of the present glass samples. The FTIR spectra revealed the presence of BO3 and BO4 structural units in SABM glasses. The IR peak at ~467 and ~679 cm-1 assigned as the vibration of metal cations (Sr2+ ), MnO bond vibrations and bending vibration of AlO in [AlO4 ] units. The Raman band ~786 cm-1 establishes the presence of AlO4 units...
November 19, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30471528/insights-about-urinary-hippuric-and-citric-acid-as-biomarkers-of-fruit-and-vegetable-intake-in-patients-with-kidney-stones-the-role-of-age-and-sex
#6
Angela Guerra, Andrea Ticinesi, Franca Allegri, Antonio Nouvenne, Beatrice Prati, Silvana Pinelli, Roberta Merli, Claudio Tana, Fulvio Lauretani, Rosalia Aloe, Loris Borghi, Tiziana Meschi
OBJECTIVES: Urinary hippuric acid (HA) and citrate can represent useful biomarkers of fruit and vegetable (FAV) intake in nephrolithiasis. However, their clinical significance across the life span has been poorly investigated. The aim of this study was to investigate the association between the two biomarkers with FAV intake across different age groups and sexes in a large group of stone formers (SFs). METHODS: SFs undergoing baseline 24-h urinary collection for metabolic profile of lithogenic risk at our institution were consecutively enrolled for a 6-y time span (N = 1185; 625 men)...
August 22, 2018: Nutrition
https://www.readbyqxmd.com/read/30469366/assessing-the-aflatoxin-b%C3%A2-adsorption-capacity-between-biosorbents-using-an-in-vitro-multicompartmental-model-simulating-the-dynamic-conditions-in-the-gastrointestinal-tract-of-poultry
#7
Anai Zavala-Franco, Daniel Hernández-Patlán, Bruno Solís-Cruz, Raquel López-Arellano, Guillermo Tellez-Isaias, Alma Vázquez-Durán, Abraham Méndez-Albores
Experiments were carried out to evaluate the effectiveness of three different biosorbents (banana peel, Pyracantha leaves, and Aloe powder) in removing aflatoxin B₁ (AFB₁). A noncommercial mycotoxin binder (zeolite) was used as a reference material. A laboratory model that simulated the in vivo conditions of the poultry gastrointestinal tract was utilized to prove the removal efficiency of the biosorbents when added to AFB₁-contaminated diet (100 µg/kg). The concentration of AFB₁ was determined using antibody-based immunoaffinity column and spectrofluorometry methodologies...
November 21, 2018: Toxins
https://www.readbyqxmd.com/read/30467933/a-mechanistic-theory-of-personality-dependent-movement-behaviour-based-on-dynamic-energy-budgets
#8
Andrea Campos-Candela, Miquel Palmer, Salvador Balle, Alberto Álvarez, Josep Alós
Consistent between-individual differences in movement are widely recognised across taxa. In addition, foraging plasticity at the within-individual level suggests a behavioural dependency on the internal energy demand. Because behaviour co-varies with fast-slow life history (LH) strategies in an adaptive context, as theoretically predicted by the pace-of-life syndrome hypothesis, mass/energy fluxes should link behaviour and its plasticity with physiology at both between- and within-individual levels. However, a mechanistic framework driving these links in a fluctuating ecological context is lacking...
November 22, 2018: Ecology Letters
https://www.readbyqxmd.com/read/30464815/the-extent-of-mangrove-change-and-potential-for-recovery-following-severe-tropical-cyclone-yasi-hinchinbrook-island-queensland-australia
#9
Emma Asbridge, Richard Lucas, Kerrylee Rogers, Arnon Accad
Cyclones are significant drivers of change within mangrove ecosystems with the extent of initial damage determined by storm severity, location and distribution (exposure), and influenced by species composition and structure (e.g., height). The long-term recovery of mangroves is often dependent upon hydrological regimes, as well as the frequency of storm events. On February 3, 2011, Tropical Cyclone Yasi (Category 5) made landfall on the coast of north Queensland Australia with its path crossing the extensive mangroves within and surrounding Hinchinbrook Island National Park...
November 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/30448435/alum-functionalized-graphene-oxide-nanocomplexes-for-effective-anticancer-vaccination
#10
Xiaoli Wang, Fengqiang Cao, Mengmeng Yan, Yijia Liu, Xianghui Zhu, Hongfan Sun, Guilei Ma
Aluminum-based adjuvant (e.g., aluminum oxyhydroxide (AlO(OH), known as the commercial Alhydrogel® (Alum)) is the first adjuvant to be used in human vaccines. Although Alum shows a robust induction of antibody-mediated immunity, its weak stimulation of cell-mediated immunity makes it a questionable adjuvant for cancer immunotherapy. Herein, we described a novel formulation of Alum-based adjuvant by preparing AlO(OH)-modified graphene oxide (GO) nanosheets (GO-AlO(OH)), which, in addition to maintaining the induction of humoral immune response by AlO(OH), could further elicit the cellular immune response by GO...
November 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30447936/enhanced-recovery-after-hepatic-surgery
#11
R Brustia, K Slim, O Scatton
INTRODUCTION: In a majority of cases, enhanced recovery after surgery program (ERP) leads to a reduced rate of postoperative complications and shortened hospital stays following digestive surgery. The program's preoperative, perioperative and postoperative measures are implemented by the members of a motivated multidisciplinary team. Having shown its merits in digestive surgery, ERP would be particularly useful in liver surgery due to the elevated rates of morbidity and mortality this type of operation continues to entail...
November 14, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/30445775/pharmaceutical-standardization-and-physicochemical-characterization-of-traditional-ayurvedic-marine-drug-incinerated-conch-shell-shankha-bhasma
#12
Sandeep Chavan, Sonali Tayade, Vidya Gupta, Vineeta Deshmukh, Sadanand Sardeshmukh
Natural resources such as plants, animals and minerals have always been used by mankind to develop drugs and marine world is no exception. Marine by-products like conches, pearls, mother of pearl shells, corals and so forth have been used by traditional Ayurvedic practitioners for centuries. The unique methods of these preparations are scientifically designed to eliminate unwanted impurities and convert them into bioavailable form. In this study, Conch ( Xanchus pyrum ) was used as a marine resource of calcium carbonate and was converted pharmaceutically from its aragonite form to calcite...
November 15, 2018: Marine Drugs
https://www.readbyqxmd.com/read/30445288/metabolism-and-mutual-biotransformations-of-anthraquinones-and-anthrones-in-rhubarb-by-human-intestinal-flora-using-uplc-q-tof-ms
#13
Zhenghai Huang, Yang Xu, Qing Wang, Xiaoyan Gao
Anthraquinones and anthrones are the main active components of rhubarb. To investigate the metabolism and possible mutual biotransformations pathways of anthraquinones and anthrones by human intestinal flora, 9 representative constituents (aloe-emodin, rhein, emodin, chrysophanol, physcion, sennosides A, B, C and D) were studied. An ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) with mass spectrometryElevated Energy (MSE ) technology was employed to separate and identify their metabolites...
October 26, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/30444474/hospital-doors-under-pressure-policies-and-trends-in-the-major-tertiary-care-hospital-in-albania
#14
EDITORIAL
I Akshija, A Dibra
OBJECTIVES: Quantification of elective and emergency hospital admissions as a resultant of patients' diagnostic and therapeutic pathways (referral system) and patients' preferences to choose the health-care provider. DESIGN: Retrospective analysis of routine hospital discharge data. Findings were analyzed with descriptive statistical methods. SETTING: University Hospital Center, "Mother Teresa", Albania, a secondary and tertiary health care provider to the capital Tirana and tertiary health care provider for the rest of Albania...
September 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/30423728/preparation-and-characterization-of-aloe-vera-acetate-and-electrospinning-fibers-as-promising-antibacterial-properties-materials
#15
Nargess Aghamohamadi, Naser Sharifi Sanjani, Reza Faridi Majidi, Saman Ahmad Nasrollahi
In this work, the anti-bacterial effect of Aloe vera derivate fibers produced by the electrospinning method was reported. Aloe vera Polyvinylpyrrolidone (Av/PVP) and Aloe vera acetate-Polyvinylpyrrolidone (AvAc/PVP) electrospun fibers were prepared with different concentrations and their microstructure and mechanical properties were studied. Various methods such as differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), water contact angle (CA) tests, Fourier-Transform Nuclear Magnetic Resonance (FT-NMR), scanning electron microscope (SEM), X-ray diffraction (XRD), CHNSO and Fourier-Transform Infrared Spectroscopy (FT-IR) were used to characterize prepared samples...
January 1, 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30408789/genistein-modifies-hamster-behavioral-and-expression-of-inflammatory-factors-following-sub-chronic-unpredictable-mild-stress
#16
Raffaella Alò, Merylin Zizza, Gilda Fazzari, Rosa Maria Facciolo, Marcello Canonaco
Previous studies have pointed to the protective role of genistein against stress adaptations despite neuromolecular mechanisms are not yet fully known. With this work, we evaluated the influence of such a phytoestrogen on hamster behavioral and molecular activities following exposure to sub-chronic unpredictable mild stress (sCUMS). <br><br>Methods: Motor behaviors of hamsters (n = 28) were analyzed using elevated plus-maze (EPM), hole board test (HB) and forced swim test (FST). In addition, neurodegeneration events were assessed with amino cupric silver stain (ACS) while expression variations of tropomyosin receptor-B kinase (TrkB), nuclear factor kappa- light-chain-enhancer of activated B1 cells (NF-kB1), and heat shock protein 70 (Hsp70) mRNAs were highlighted in limbic neuronal fields via in situ hybridization (ISH)...
November 8, 2018: Neuroendocrinology
https://www.readbyqxmd.com/read/30407344/prognostic-value-of-the-systematic-immune-inflammation-index-among-patients-with-operable-colon-cancer-a-retrospective-study
#17
Ming-Yue Tao, Zhong-Hong Wang, Meng-Hui Zhang, Tian-Heng Ma, Xiao-Zhong Yang, Shang-Nong Wu, Xiao-Fei Chen, Hong-Gang Wang
The systematic immune-inflammation index (SII) has been used to predict the prognosis of patients with various cancers. This study aimed to determine whether the preoperative SII was associated with postoperative survival among patients with operable colon cancer.This retrospective study included 118 age- and sex-matched healthy subjects and 118 patients who underwent radical surgery for colon cancer between January 2011 and December 2013. The preoperative SII was calculated based on counts of neutrophils, lymphocytes, and platelets in the peripheral blood...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30404637/aloe-emodin-induces-apoptosis-in-human-oral-squamous-cell-carcinoma-scc15-cells
#18
Qihong Li, Jun Wen, Kaitao Yu, Yao Shu, Wulin He, Hongxing Chu, Bin Zhang, Cheng Ge
BACKGROUND: Oral and pharyngeal cancer is the most common malignant human cancers. Chemotherapy is an effective approach for anti-oral cancer therapy, while the drug tolerance and resistance remain a problem for oral cancer patients. Aloe-emodin, rhein and physcion are classified as anthraquinones, which are the main pharmacodynamic ingredients of Rheum undulatum L.. This study was undertaken to investigate whether aloe-emodin, rhein and physcion show inhibiting growth and inducing apoptosis in oral squamous cell carcinoma SCC15 cells...
November 7, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/30402868/endogenous-nerve-growth-factor-stimulation-effects-on-auditory-pathway-neural-cells-in-a-mouse-model
#19
F Salvinelli, V Frari, F Capuano, B Salvinelli, M L Rocco, L Aloe
OBJECTIVE: In the present study, we investigated whether high-pressure hypotonic saline solution (Hphss) affects the basal level of Nerve Growth Factor (NGF) and expression of receptors in the cochlea, bark earing, retina, and visual cortex. MATERIALS AND METHODS: For this study, we used three weeks old female Sprague Dawley (SD) rats (n = 12). Rats were housed in polypropylene cages and were kept under standard conditions (12 h light:12 h dark cycle) with free access to water and food (Purina chow food)...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30397457/evaluating-the-ability-of-community-protected-forests-in-cambodia-to-prevent-deforestation-and-degradation-using-temporal-remote-sensing-data
#20
Minerva Singh, Damian Evans, Jean-Baptiste Chevance, Boun Suy Tan, Nicholas Wiggins, Leaksmy Kong, Sakada Sakhoeun
Community forests are known to play an important role in preserving forests in Cambodia, a country that has seen rapid deforestation in recent decades. The detailed evaluation of the ability of community-protected forests to retain forest cover and prevent degradation in Cambodia will help to guide future conservation management. In this study, a combination of remotely sensing data was used to compare the temporal variation in forest structure for six different community forests located in the Phnom Kulen National Park (PKNP) in Cambodia and to assess how these dynamics vary between community-protected forests and a wider study area...
October 2018: Ecology and Evolution
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