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https://www.readbyqxmd.com/read/30503361/noradrenaline-reuptake-inhibition-increases-control-of-impulsive-action-by-activating-d-1-like-receptors-in-the-infralimbic-cortex
#1
Hitomi Sasamori, Yu Ohmura, Takayuki Yoshida, Mitsuhiro Yoshioka
Higher impulsivity is a risk factor for criminal involvement, substance abuse, and suicide. However, only a few drugs are clinically available for the treatment of deficient impulse control. We recently proposed a strategy for identifying potential drugs to treat such disorders by investigating clinically available drugs that increase extracellular dopamine levels in the medial prefrontal cortex and stimulate dopamine D1 -like receptors without increasing extracellular dopamine levels in the ventral striatum...
November 29, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30462746/the-kcnh3-inhibitor-asp2905-shows-potential-in-the-treatment-of-attention-deficit-hyperactivity-disorder
#2
Shinji Takahashi, Makoto Ohmiya, Sokichi Honda, Keni Ni
N-(4-fluorophenyl)-N'-phenyl-N"-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine [ASP2905] is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3) that was originally identified in our laboratory. KCNH3 is concentrated in the forebrain, and its overexpression in mice leads to cognitive deficits. In contrast, Kcnh3 knockout mice exhibit enhanced performance in cognitive tasks such as attention. These data suggest that KCNH3 plays important roles in cognition...
2018: PloS One
https://www.readbyqxmd.com/read/30365404/cardiovascular-effects-of-drugs-used-to-treat-attention-deficit-hyperactivity-disorder-part-1-epidemiology-pharmacology-and-impact-on-hemodynamics-and-ventricular-repolarization
#3
Thomas B Fay, Martin A Alpert
Attention-deficit/hyperactivity disorder (ADHD) is a clinical syndrome characterized by persistent inattention, impulsivity and hyperactivity. It is most commonly encountered in children and adolescents, but may persist into adulthood. A variety of psychostimulant and non-psychostimulant medications have proven to be successful in reducing inattention, impulsivity and hyperactivity in those with ADHD. Psychostimulants used to treat ADHD include methylphenidate and related drugs and various amphetamine preparations...
October 25, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/30346335/the-role-of-atomoxetine-for-parkinson-disease-related-executive-dysfunction-a-systematic-review
#4
Carly B Warner, Andreina A Ottman, Jamie N Brown
BACKGROUND: Atomoxetine selectively inhibits the reuptake of norepinephrine. Given the noradrenergic system's role in executive function, pharmacotherapy options that affect norepinephrine are of particular clinical interest in Parkinson disease-related executive dysfunction. OBJECTIVE: The aim of this study was to assess the efficacy and safety of atomoxetine for Parkinson disease-related executive dysfunction. METHODS: MEDLINE (1946 to May 2018) and EMBASE (1947 to May 2018) were queried using the search term combination: Parkinson's disease, Parkinson disease, inhibition, impulse behavior, impulse control disorder, executive function, executive dysfunction, cognition, cognitive dysfunction, cognitive defect, response inhibition, strategic planning, strategy, or verbal fluency and atomoxetine hydrochloride or atomoxetine...
December 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30332620/light-up-adhd-ii-neuropharmacological-effects-measured-by-near-infrared-spectroscopy-is-there-a-biomarker
#5
REVIEW
Silvia Grazioli, Maddalena Mauri, Alessandro Crippa, Eleonora Maggioni, Massimo Molteni, Paolo Brambilla, Maria Nobile
BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD. METHODS: We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD...
October 9, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30314873/facial-nerve-palsy-associated-with-atomoxetine-induced-hypertension
#6
Hironobu Kobayashi, Katsunori Fujii, Masayo Kobayashi, Naoki Saito, Kentaro Okunushi, Ryota Ebata, Tadashi Shiohama, Daisuke Sawada, Naoki Shimojo
BACKGROUND: Peripheral facial nerve palsy is characterized by unilateral facial paresis due to ipsilateral facial nerve dysfunction. Most cases are idiopathic; however, some have specific etiologies, such as herpesvirus infection, immunological disorders, and hypertension. Atomoxetine is a norepinephrine reuptake inhibitor that is used in the treatment of attention deficit hyperactivity disorder (ADHD). This drug is known to cause adverse effects, such as nausea, appetite loss, headache, insomnia, and hypertension...
October 9, 2018: Brain & Development
https://www.readbyqxmd.com/read/30267796/atomoxetine-prevents-working-memory-loss-in-hyperactive-rats-mediating-plastic-changes-in-prefrontal-cortex-pyramidal-neurons
#7
Néstor I Martínez-Torres, David González-Tapia, Nallely Vázquez-Hernández, Ignacio González-Burgos
Attention Deficit Hyperactivity Disorder (ADHD) causes impaired visuospatial working memory (VWM), which primarily maps to the prefrontal cortex. However, little is known about the synaptic processes underlying cognitive loss in ADHD, or those ultimately involved in the preventive effect observed through the clinical use of Atomoxetine (ATX). To investigate the plasticity underlying ADHD related cognitive loss, and that potentially involved in the preventive action of Atomoxetine, allocentric VWM was assessed, as well as the dendritic spine number and proportional density on pyramidal neurons in the prefrontal cerebral cortex layer III of neonatal 6-hydroxydopamine-lesioned rats...
December 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/30198448/therapy-for-fatigue-and-cognitive-dysfunction-in-postural-orthostatic-tachycardia-syndrome
#8
Jeffrey R Boris, Thomas Bernadzikowski
IntroductionSevere fatigue and cognitive dysfunction are frequent symptoms in patients with postural orthostatic tachycardia syndrome. They can be debilitating, and often do not resolve despite improvement in haemodynamic symptoms. Our analysis was intended to assess clinical outcomes of medication treatment for these symptoms in a large, single-centre paediatric programme.Materials and MethodsWe performed a retrospective review of patients treated for fatigue and cognitive dysfunction. Patients aged 18 years or younger at the time of initial diagnosis were included...
September 10, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/30178479/systematic-review-of-the-screening-diagnosis-and-management-of-adhd-in-children-with-epilepsy-consensus-paper-of-the-task-force-on-comorbidities-of-the-ilae-pediatric-commission
#9
Stéphane Auvin, Elaine Wirrell, Kirsten A Donald, Madison Berl, Hans Hartmann, Kette D Valente, Patrick Van Bogaert, J Helen Cross, Makiko Osawa, Hideaki Kanemura, Masao Aihara, Marilisa M Guerreiro, Pauline Samia, Kollencheri Puthenveettil Vinayan, Mary Lou Smith, Lionel Carmant, Michael Kerr, Bruce Hermann, David Dunn, Jo M Wilmshurst
Attention-deficit/hyperactivity disorder (ADHD) is a common and challenging comorbidity affecting many children with epilepsy. A working group under the International League Against Epilepsy (ILAE) Pediatric Commission identified key questions on the identification and management of ADHD in children with epilepsy. Systematic reviews of the evidence to support approaches to these questions were collated and graded using criteria from the American Academy of Neurology Practice Parameter. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) requirements were followed, with PROSPERO registration (CRD42018094617)...
October 2018: Epilepsia
https://www.readbyqxmd.com/read/30172446/management-of-attention-deficit-disorder-and-attention-deficit-hyperactivity-disorder-drug-intoxication-in-dogs-and-cats-an-update
#10
REVIEW
Laura Stern, Mary Schell
Amphetamines and the nonamphetamine atomoxetine are commonly used in the treatment of attention-deficit disorder/attention-deficit/hyperactivity disorder in humans. Because these medications are often found in homes, dog and cat exposure to these medications is a common intoxication. Amphetamine intoxication can cause life-threatening central nervous system and cardiovascular stimulation, even when small amounts are ingested.
November 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/30126223/antihyperalgesic-activity-of-atomoxetine-on-diabetes-induced-neuropathic-pain-contribution-of-noradrenergic-and-dopaminergic-systems
#11
Mustafa Burak Barbaros, Özgür Devrim Can, Umut İrfan Üçel, Nazlı Turan Yücel, Ümide Demir Özkay
Atomoxetine is a selective noradrenaline reuptake inhibitor drug. Based on the knowledge that agents increasing monoamine levels in the central nervous system have therapeutic potential for neuropathic pain, it is planned to investigate the possible efficacy of atomoxetine on diabetes-induced hyperalgesia, in this study. Randall-Selitto (mechanical noxious stimuli) and Hargreaves (thermal noxious stimuli) tests were used to evaluate nociceptive perception of rats. Obtained data indicated that streptozotocin-induced diabetes causes significant decreases in the paw withdrawal threshold and paw withdrawal latency values of the animals, respectively...
August 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30125623/the-atxn7-overexpressing-mice-showed-hyperactivity-and-impulsivity-which-were-ameliorated-by-atomoxetine-treatment-a-possible-animal-model-of-the-hyperactive-impulsive-phenotype-of-adhd
#12
Irene Joy I Dela Peña, Chrislean Jun Botanas, June Bryan de la Peña, Raly James Custodio, Ike Dela Peña, Zae Young Ryoo, Bung-Nyun Kim, Jong Hoon Ryu, Hee Jin Kim, Jae Hoon Cheong
Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder characterized by varying levels of hyperactivity, inattention, and impulsivity. Patients with ADHD are often classified as (1) predominantly hyperactive-impulsive, (2) predominantly inattentive, and (3) combined type. There is a growing interest in developing specific animal models that would recapitulate specific clinical forms of ADHD, with the goal of developing specific therapeutic strategies. In our previous study, we have identified Ataxin-7 (Atxn7) as a hyperactivity-associated gene...
January 10, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/30122296/-supervised-off-label-prescribing-of-methylphenidate-in-adult-adhd
#13
L Carton, T Dondaine, S Deheul, C Marquié, F Brigadeau, A Amad, D Devos, T Danel, R Bordet, O Cottencin, S Gautier, O Ménard
OBJECTIVE: Off-label prescription is a common practice in psychiatry, raising health and economic concerns. Collegial consultation could allow a framed prescription of treatments that are not authorized in specific indications. Attention Deficit Hyperactivity in adult populations (ADHD) is a striking example of a pathology where off-label prescription is frequent. First considered to be a childhood disorder, the awareness of this condition in adults is increasing, leading to the development of new clinical practices and treatments...
August 16, 2018: L'Encéphale
https://www.readbyqxmd.com/read/30102629/incidence-of-heart-failure-and-cardiomyopathy-following-initiation-of-medications-for-attention-deficit-hyperactivity-disorder-a-descriptive-study
#14
Andrew D Mosholder, Lockwood Taylor, Glenn Mannheim, Lisa Ortendahl, Tiffany S Woodworth, Sengwee Toh
PURPOSE/BACKGROUND: Stimulant abuse is associated with cardiomyopathy, but cardiomyopathy rates with therapeutic use of stimulants for attention-deficit/hyperactivity disorder (ADHD) are poorly characterized. Labels for methylphenidate, amphetamine, and atomoxetine caution against use in patients with cardiovascular disease. We sought to assess the incidence of new-onset heart failure or cardiomyopathy among initiators of these medications. METHODS/PROCEDURES: Using the Sentinel distributed database, we analyzed new-onset heart failure or cardiomyopathy among initiators of selected ADHD medications (amphetamine products including lisdexamfetamine, methylphenidate, and atomoxetine), by duration of use (0-90, 91-180, 181-270, 271-365, 366-730, and 731-1095 days) and age group (<22, 22-44, 45-64, and ≥65 years)...
October 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30097390/comparative-efficacy-and-tolerability-of-medications-for-attention-deficit-hyperactivity-disorder-in-children-adolescents-and-adults-a-systematic-review-and-network-meta-analysis
#15
Samuele Cortese, Nicoletta Adamo, Cinzia Del Giovane, Christina Mohr-Jensen, Adrian J Hayes, Sara Carucci, Lauren Z Atkinson, Luca Tessari, Tobias Banaschewski, David Coghill, Chris Hollis, Emily Simonoff, Alessandro Zuddas, Corrado Barbui, Marianna Purgato, Hans-Christoph Steinhausen, Farhad Shokraneh, Jun Xia, Andrea Cipriani
BACKGROUND: The benefits and safety of medications for attention-deficit hyperactivity disorder (ADHD) remain controversial, and guidelines are inconsistent on which medications are preferred across different age groups. We aimed to estimate the comparative efficacy and tolerability of oral medications for ADHD in children, adolescents, and adults. METHODS: We did a literature search for published and unpublished double-blind randomised controlled trials comparing amphetamines (including lisdexamfetamine), atomoxetine, bupropion, clonidine, guanfacine, methylphenidate, and modafinil with each other or placebo...
September 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/30037827/amplification-and-suppression-of-distinct-brainwide-activity-patterns-by-catecholamines
#16
Ruud L van den Brink, Sander Nieuwenhuis, Tobias H Donner
The widely projecting catecholaminergic (norepinephrine and dopamine) neurotransmitter systems profoundly shape the state of neuronal networks in the forebrain. Current models posit that the effects of catecholaminergic modulation on network dynamics are homogeneous across the brain. However, the brain is equipped with a variety of catecholamine receptors with distinct functional effects and heterogeneous density across brain regions. Consequently, catecholaminergic effects on brainwide network dynamics might be more spatially specific than assumed...
August 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29982276/orthostatic-hypotension-in-the-hypertensive-patient
#17
Italo Biaggioni
Orthostatic hypotension (OH) is an important and common medical problem, particularly in the frail elderly with multiple comorbidities and polypharmacy. OH is an independent risk factor for falls and overall mortality. Hypertension is among the most common comorbidities associated with OH, and its presence complicates the management of these patients because treatment of one can worsen the other. However, there is evidence that uncontrolled hypertension worsens OH so that both should be managed. The limited data available suggest that angiotensin receptor blockers and calcium channel blockers are preferable antihypertensives for these patients...
November 13, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29944175/pharmacological-treatment-for-attention-deficit-hyperactivity-disorder-adhd-in-children-with-comorbid-tic-disorders
#18
REVIEW
Sydney T Osland, Thomas Dl Steeves, Tamara Pringsheim
BACKGROUND: This is an update of the original Cochrane Review published in Issue 4, 2011.Attention deficit hyperactivity disorder (ADHD) is the most prevalent of the comorbid psychiatric disorders that complicate tic disorders. Medications commonly used to treat ADHD symptoms include stimulants such as methylphenidate and amphetamine; non-stimulants, such as atomoxetine; tricyclic antidepressants; and alpha agonists. Alpha agonists are also used as a treatment for tics. Due to the impact of ADHD symptoms on the child with tic disorder, treatment of ADHD is often of greater priority than the medical management of tics...
June 26, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29940719/effects-of-atomoxetine-on-height-and-weight-in-korean-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-retrospective-chart-review
#19
Kukju Kweon, Je Sik Yoon, Kee Jeong Park, Seon-Ok Kim, Jin-Ho Choi, Hyo-Won Kim
Objective: We aimed to investigate the long-term effects of atomoxetine on growth in Korean children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Methods: The medical records of 82 subjects (mean age, 9.0±2.0 years; 64 boys) with ADHD treated with atomoxetine for at least 1 year at the Department of Psychiatry at Asan Medical Center were retrospectively reviewed. Height and weight data were prospectively obtained and retrospectively gathered and converted to age- and gender-corrected z scores using norms from Korean youths...
June 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29927781/long-term-tolerability-and-safety-of-pharmacological-treatment-of-adult-attention-deficit-hyperactivity-disorder-a-6-year-prospective-naturalistic-study
#20
Dan Edvinsson, Lisa Ekselius
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a behavioral disorder typically treated with stimulants and atomoxetine. Data on long-term tolerability and safety of such pharmacological treatment in subjects diagnosed in adulthood are limited. METHODS: A cohort of adults diagnosed with ADHD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria was followed-up on an average of 6 years after first evaluation. Of 168 adults, 112 (67%) who initiated medication were available for follow-up...
August 2018: Journal of Clinical Psychopharmacology
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