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Drug Delivery Application

Wanderson M Silva, Cassiana S Sousa, Leticia C Oliveira, Siomar C Soares, Gustavo F M H Souza, Guilherme C Tavares, Cristiana P Resende, Edson L Folador, Felipe L Pereira, Henrique Figueiredo, Vasco Azevedo
Lactococcus lactis is a bacteria with high biotechnological potential, where is frequently used in the amino acid production and production of fermented dairy products, as well as drug delivery systems and mucosal vaccine vector. The knowledge of a functional core proteome is important extremely for both fundamental understanding of cell functions and for synthetic biology applications. In this study, we characterized the L. lacits proteome from proteomic analysis of four biotechnological strains L. lactis: L...
October 19, 2018: Microbial Biotechnology
Yu-Lin Su, Shang-Hsiu Hu
Theranostic nanoparticles recently received great interest for uniting unique functions to amplify therapeutic efficacy and reduce side effects. Despite the enhanced permeability and retention (EPR) effect, which amplifies the accumulation of nanoparticles at the site of a tumor, tumor heterogeneity caused by the dense extracellular matrix of growing cancer cells and the interstitial fluid pressure from abnormal angiogenesis in the tumor inhibit drug/particle penetration, leading to inhomogeneous and limited treatments...
October 18, 2018: Pharmaceutics
Vijay Mishra, Kuldeep K Bansal, Asit Verma, Nishika Yadav, Sourav Thakur, Kalvatala Sudhakar, Jessica M Rosenholm
Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide...
October 18, 2018: Pharmaceutics
Meiyu Gai, Wenhao Li, Johannes Frueh, Gleb B Sukhorukov
Surface mediated drug delivery is important for a large variety of applications, especially in medicine to control cell growth, prevent blood platelet activation on implants or for self-disinfecting devices (e.g. catheters). In industrial applications, controlled release of substances from surfaces is needed in a broad range of applications from anti-corrosion systems to anti-biofouling. Polyelectrolyte multilayers (PEM) based microcontainers (MCs) require several days production time, while MCs composed out of polylactic acid (PLA) are entirely hydrophobic, offering no functionality...
October 10, 2018: Colloids and Surfaces. B, Biointerfaces
B Sundararajan, Anil Kumar Moola, K Vivek, B D Ranjitha Kumari
The present study, emphasis on the encapsulation of Ocimum basilicum L. leaf essential oil by utilizing Polysorbate 80 and its evaluation of antibacterial (MIC), antioxidants and larvicidal activity against C. quinquefasciatus. After the encapsulation, nanoemulsion characterized by using a Zeta potential analyzer and Scanning Electron Microscope (SEM). Nanoemulsion was exhibited significantly more antibacterial activity (MIC) against different enteric bacterial pathogens, Enterococcus faecalis (MTCC-2729), Staphylococcus aureus (MTCC-441), Salmonella paratyphi (MTCC-735), Klebsiella pneumoniae (MTCC-432) and antioxidant ability of the formulated nanoemulsion and essential oil was tested and results of DPPH, Hydroxyl radical scavenging activity, Superoxide scavenging activity and FRAP activities exhibits highest antioxidant activity...
October 16, 2018: Microbial Pathogenesis
S Pawłowska, T A Kowalewski, F Pierini
Over the past few decades, there has been strong interest in the development of new micro- and nanomaterials for biomedical applications. Their use in the form of capsules, particles or filaments suspended in body fluids is associated with conformational changes and hydrodynamic interactions responsible for their transport. The dynamics of fibres or other long objects in Poiseuille flow is one of the fundamental problems in a variety of biomedical contexts, such as mobility of proteins, dynamics of DNA or other biological polymers, cell movement, tissue engineering, and drug delivery...
October 19, 2018: Soft Matter
Anne Clavreul, Emilie Roger, Milad Pourbaghi-Masouleh, Laurent Lemaire, Clément Tétaud, Philippe Menei
Anticancer agents that target both tumor cells and angiogenesis are of potential interest for glioblastoma (GB) therapy. One such agent is sorafenib (SFN), a tyrosine kinase inhibitor. However, poor aqueous solubility and undesirable side effects limit its clinical application, including local treatment. We encapsulated SFN in lipid nanocapsules (LNCs) to overcome these drawbacks. LNCs are nanocarriers formulated according to a solvent-free process, using only components that have received regulatory approval...
November 2018: Drug Delivery
Jun-Yong Wu, Yong-Jiang Li, Le Yang, Yi-Yun Hu, Xiong-Bin Hu, Tian-Tian Tang, Jie-Min Wang, Xin-Yi Liu, Da-Xiong Xiang
Puerarin (PUE) and tetramethylpyrazine (TMP) are central nervous system (CNS) drugs used in cerebrovascular diseases. Poor brain-blood barrier (BBB) permeability limited their clinical application. Borneol and α-asarone have been proposed as an oral brain-targeting enhancer. In this study, we aimed to first evaluate the 'orifice-opening' effect of borneol and α-asarone, both aromatic resuscitation drugs, on improvement of brain delivery of PUE and TMP and second to investigate whether the enhancing effects were associated with adenosine receptors (ARs)-mediated trans-BBB pathway...
November 2018: Drug Delivery
Jing Chen, Yue Tang, Yun Liu, Yushun Dou
Nucleic acid-based therapeutics present huge potential in the treatment of pulmonary diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are often fatal and widely prevalent. The susceptibility of nucleic acids to degradation and the complex structure of lungs retard the effective pulmonary delivery of nucleic acid drug. To overcome these barriers, different strategies have been exploited to increase the delivery efficiency using chemically synthesized nucleic acids, vector encapsulation, proper formulation, and administration route...
October 18, 2018: AAPS PharmSciTech
Ki-Taek Kim, Min-Hwan Kim, Ju-Hwan Park, Jae-Young Lee, Hyun-Jong Cho, In-Soo Yoon, Dae-Duk Kim
Background: 20( S )-Protopanaxadiol (20 S -PPD) is a fully deglycosylated ginsenoside metabolite and has potent dermal antiaging activity. However, because of its low aqueous solubility and large molecular size, a suitable formulation strategy is required to improve its solubility and skin permeability, thereby enhancing its skin deposition. Thus, we optimized microemulsion (ME)-based hydrogel (MEH) formulations for the topical delivery of 20 S -PPD. Methods: MEs and MEHs were formulated and evaluated for their particle size distribution, morphology, drug loading capacity, and stability...
October 2018: Journal of Ginseng Research
Rakesh K Pathak, Uttara Basu, Anis Ahmad, Shrita Sarkar, Anil Kumar, Bapurao Surnar, Saba Ansari, Katarzyna Wilczek, Michael E Ivan, Brian Marples, Nagesh Kolishetti, Shanta Dhar
Multimodal therapies are used to treat advanced cancers including castration-resistant prostate cancer to manage the biological characteristics of the tumors like inflammation, bone metastases, and participation of metabolically altered cancer stem cells (CSCs) that have integral roles in disease dissemination and progression. We developed a multifunctional polymer-based self-assembled technology to deliver a predefined stoichiometric combination of a chemotherapy and an anti-inflammatory agent in a stimuli responsive manner, to complement and improve the currently established treatment methods of prostate cancer...
September 5, 2018: Biomaterials
Yiliang Lin, Jan Genzer, Weihua Li, Ruirui Qiao, Michael D Dickey, Shi-Yang Tang
Gallium-based liquid metals are attractive due to their unique combination of metallic and fluidic properties. Liquid metal nanoparticles (LM NPs), produced readily using sonication, find use in soft electronics, drug delivery, and other applications. However, LM NPs in aqueous solutions tend to oxidize and precipitate over time, which hinders their utility in systems that require long-term stability. Here, we introduce a facile route to rapidly produce an aqueous suspension of stable LM NPs within five minutes...
October 18, 2018: Nanoscale
A Bryja, M Dyszkiewicz-Konwińska, Y Huang, P Celichowski, M J Nawrocki, M Jankowski, K Błochowiak, K Mehr, P Ramlau, A Nowicki, D Bukowska, P Antosik, K Osmola, M Bruska, M Zabel, M Nowicki, B Kempisty
Extraordinary abilities for continuous proliferation and differentiation, associated with constant renewal triggered by stimulation from the mastication process, together with the relative lack of aesthetic complications associated with post-surgery healing, have highlighted buccal pouch mucosa as a potential source of explants that could be used in transplantation and tissue engineering. Additionally, this tissue plays a major role in the oral drug delivery process, which brings special interest to its molecular properties in the context of new drug development...
September 2018: Journal of Biological Regulators and Homeostatic Agents
Thomas Schlake, Andreas Thess, Moritz Thran, Ingo Jordan
While active immunization elicits a lasting immune response by the body, passive immunotherapy transiently equips the body with exogenously generated immunological effectors in the form of either target-specific antibodies or lymphocytes functionalized with target-specific receptors. In either case, administration or expression of recombinant proteins plays a fundamental role. mRNA prepared by in vitro transcription (IVT) is increasingly appreciated as a drug substance for delivery of recombinant proteins. With its biological role as transient carrier of genetic information translated into protein in the cytoplasm, therapeutic application of mRNA combines several advantages...
October 17, 2018: Cellular and Molecular Life Sciences: CMLS
Yi Liu, Shan-Hui Hsu
Hydrogels, which are crosslinked polymer networks with high water contents and rheological solid-like properties, are attractive materials for biomedical applications. Self-healing hydrogels are particularly interesting because of their abilities to repair the structural damages and recover the original functions, similar to the healing of organism tissues. In addition, self-healing hydrogels with shear-thinning properties can be potentially used as the vehicles for drug/cell delivery or the bioinks for 3D printing by reversible sol-gel transitions...
2018: Frontiers in Chemistry
Gayatri Patel, Bindu Kumari N Yadav
In recent years, researchers have been used polymeric nanofibers for various drug delivery and tissue engineering scaffolds applications. Nanofibers exhibit a wide range of unique features and properties, such as the simplicity of their fabrication, the diversity of materials suitable for processing into fibers, possession of high surface area and a complex pore structure. Nanofibers possess effective drug-loading capacity and targeting, controlled release as well as stability that have attracted much attention for their application for drug delivery...
October 17, 2018: Recent Patents on Nanotechnology
Jianghua Li, Chao Cai, Jiarui Li, Jun Li, Jia Li, Tiantian Sun, Lihao Wang, Haotian Wu, Guangli Yu
This review discusses different forms of nanomaterials generated from chitosan and its derivatives for controlled drug delivery. Nanomaterials are drug carriers with multiple features, including target delivery triggered by environmental, pH, thermal responses, enhanced biocompatibility, and the ability to cross the blood-brain barrier. Chitosan (CS), a natural polysaccharide largely obtained from marine crustaceans, is a promising drug delivery vector for therapeutics and diagnostics, owing to its biocompatibility, biodegradability, low toxicity, and structural variability...
October 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Maria Nerantzaki, Eirini Skoufa, Kyriakos-Vasileios Adam, Stavroula Nanaki, Apostolos Avgeropoulos, Margaritis Kostoglou, Dimitrios Bikiaris
In the present study, the newly synthesized castor oil-derived thioether-containing ω-hydroxyacid (TEHA) block copolymers with polycaprolactone (TEHA-b-PCL), with methoxypoly(ethylene glycol) (mPEG), (TEHA-b-mPEG) and with poly(ethylene glycol) (PEG) (TEHA-b-PEG-b-TEHA), were investigated as polymeric carriers for fabrication of naltrexone (NLX)-loaded microspheres by the single emulsion solvent evaporation technique. These microspheres are appropriate for the long-term treatment of opioid/alcohol dependence...
October 16, 2018: Materials
Małgorzata Szulc, Aneta Zakrzewska, Jacek Zborowski
Traditional methods of non-surgical treatment of periodontitis, including mechanical scaling/root planing (SRP), do not guarantee remission of the disease. Local delivery of antimicrobial agents in periodontitis entails antimicrobial therapy placed directly in periodontal pockets. The advantage of this form of treatment is that the concentration of the drug after application significantly exceeds the minimum inhibitory concentration (MIC) and persists for up to several weeks. Therefore, many systems of locally applied devices, using a variety of antibiotics or antiseptics have been developed...
July 2018: Dental and medical problems
Aliye Uc, Dana K Andersen, Drucy Borowitz, Marshall J Glesby, Julia Mayerle, Robert Sutton, Stephen J Pandol
A workshop was sponsored by the Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, on July 25, 2018, in Pittsburgh, Penn. The workshop was designed to bring together a multidisciplinary group of experts to accelerate the development of therapeutics for clinical application in inflammatory diseases of the exocrine pancreas. Three separate working groups (acute pancreatitis, recurrent acute pancreatitis, and chronic pancreatitis) were formed to address the needs, gaps, and opportunities...
November 2018: Pancreas
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