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Kang Chen, Jie Wang, Shiyan Li, Yang Wang, Yiqi Zhang, Qing Shen
Tetracyclines abuse is frequently occurred in aquaculture against bacteria, rickettsiae, spirochetes and mycoplasmas. In this study, a high-throughput sample preparation method was developed using 96-well plate solid-phase extraction (p-SPE) and the extract was anal. yzed by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The experimental conditions were optimized such that the pH is 4, the eluting solvent is methanol (2 mL), and the sorbent is hydrophilic-lipophilic balance (HLB) microsphere...
December 4, 2018: Electrophoresis
Carsten Schmelter, Sebastian Funke, Jana Treml, Anja Beschnitt, Natarajan Perumal, Caroline Manicam, Norbert Pfeiffer, Franz H Grus
Proper sample preparation protocols represent a critical step for liquid chromatography-mass spectrometry (LC-MS)-based proteomic study designs and influence the speed, performance and automation of high-throughput data acquisition. The main objective of this study was to compare two commercial solid-phase extraction (SPE)-based sample preparation protocols (comprising SOLAµTM HRP SPE spin plates from Thermo Fisher Scientific and ZIPTIP® C18 pipette tips from Merck Millipore) for analytical performance, reproducibility, and analysis speed...
December 3, 2018: International Journal of Molecular Sciences
Vincenzo Ferrone, Roberto Cotellese, Annadomenica Cichella, Paolo Raimondi, Maura Carlucci, Paola Palumbo, Giuseppe Carlucci
A simple and rapid ultra high-performance liquid chromatographic (UHPLC) for the simultaneous determination of meropenem and ciprofloxacin in human plasma was developed and validate. All the analytes were separated in less than 5 min. A solid-phase extraction method was applied from samples preparation. Analytical separation was performed on a Poroshell SB C18 column (50 x 2.1 mm, 2.7 μm particle size) with PDA detection. Meropenem and ciprofloxacin were carried out at a wavelength 300 and 277 nm, respectively...
December 4, 2018: Biomedical Chromatography: BMC
Pappula Nagaraju, Balaji Kodali, Peda Varma Datla, Surya Prakasarao Kovvasu
An accurate, highly sensitive, and precise method for quantitative analysis of tramadol (TMD) and gabapentin (GBP) by high performance liquid chromatography and tandem mass spectrometry in human plasma was proposed and validated successfully using venlafaxine and pregabalin as internal standards (ISTDs), respectively. An aliquot of 200 μ L of plasma was mixed with internal standard dilution and extraction was performed by using solid phase extraction (SPE) technique. Peak resolution was achieved on Phenomenex PFP column (50×4...
2018: International Journal of Analytical Chemistry
Hina Javed, Aminul Islam, Anjali Chauhan, Suneel Kumar, Sushil Kumar
Graphene oxide (GO) was immobilized innovatively through azo spacer arm onto the surface of polymeric Amberlite XAD-16 resin in order to expose all oxygen functionalities freely available for metal ions coordination and further modification with picolylamine which governs selectivity. The GO Amberlite XAD-16 picolylamine enables the development of SPE column coupled with ICP-OES for preconcentration and determination of Pb (II) and Cu (II) in water and fish samples. Elution was performed by mild acid (2M HCl) no other carcinogenic organic solvent was used, prevents ligand leaching...
December 3, 2018: Scientific Reports
Idalina Bragança, Paulo C Lemos, Cristina Delerue-Matos, Valentina F Domingues
3-Phenoxybenzoic acid (3-PBA) is a shared metabolite of several synthetic pyrethroid pesticides (SPs) resulting from environmental degradation of parent compounds and thus occurs frequently as a residue in samples. Hence, the importance of 3-PBA evaluation after pyrethroid application. There is a gap of analytical methods to determine 3-PBA in soil samples. Therefore, an analytical method that combines the solid-phase extraction (SPE) and gas chromatography-mass spectrometry (GC/MS) detection has been developed for the determination of 3-PBA in soil samples...
November 30, 2018: Environmental Science and Pollution Research International
Jing-Jing Pan, Zhong-Yi Sun, Xiao-Yu Zhou, Yu-Hua Hu, Rui Cheng, Xiao-Qing Chen, Yang Yang
Background: The objective of this study is to evaluate the value of neutrophil gelatinase-associated lipocalin (NGAL) for becoming a good endogenous marker of renal function in asphyxial preterm babies. Materials and Methods: This is a two-center retrospective study. Between October 2016 and October 2017, 71 asphyxial preterm infants were included in asphyxia group. Seventy babies were randomly included in control group. Samples were tested at 24, 48, and 96 h after birth...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Dianwei Zhang, Huilin Liu, Weitao Geng, Yanping Wang
Molecular imprinting is a technique for polymerization using a template molecule to produce cavities in the polymer with high selectivity. The successful synthesis of a dual-function molecularly-imprinted optopolymer (MIOP) based on quantum dots-grafted covalent-organic frameworks as adsorbents has allowed the simultaneous detection of tyramine by optosensing and solid-phase extraction coupled with high performance liquid chromatography (SPE-HPLC). The MIOP, obtained by a one-pot reverse microemulsion polymerization, selectively measured tyramine from fermented meat products...
March 30, 2019: Food Chemistry
Peipei Sun, Chi-Chun Wong, Yuelian Li, Yongjin He, Xuemei Mao, Tao Wu, Yuanyuan Ren, Feng Chen
In this study, the microalga Nitzschia laevis (N. laevis) can accumulate a marine carotenoid fucoxanthinol. In particular, fucoxanthinol was firstly isolated from microalgae, accompanied by its derivative fucoxanthin. The identification and quantification of fucoxanthinol and fucoxanthin were determined by ultra-performance liquid chromatography coupled to photodiode array detector-quadrupole/travelling-wave ion mobility mass spectrometry/time-of-flight mass spectrometry (UPLC-PDA-TWIMS-QTOF-MS). Furthermore, a cost-effective approach mediated with solid-phase extraction (SPE) and thin-layer chromatography (TLC) technique was used to isolate and purify fucoxanthinol and fucoxanthin from the extracts of N...
March 30, 2019: Food Chemistry
Shijuan Zhang, Ting Xu, Qian Liu, Jiammin Liu, Fengli Lu, Mingbo Yue, Yanxin Li, Zhiwei Sun, Jinmao You
A new cationic gemini surfactant-resorcinol/formaldehyde resin was designed and synthesized. Cationic gemini surfactant was introduced into the resorcinol/formaldehyde resin for the first time and led to the retention of negatively charged endocrine disrupting compounds (EDCs) through electrostatic interactions, hydrogen bonding and π-π interactions. The synthesized material showed good performance in the dispersive micro-solid phase extraction (D-μ-SPE) of EDCs such as alkylphenol and phenoxy acid herbicides from food packaging migrants...
March 30, 2019: Food Chemistry
Tomáš Sosna, Marcel Mikeska, Ondčrej Dutko, Gražyna Simha Martynková, Katečrina Škrlová, Karla Čech Barabaszová, Katečrina Dčedková, Pavlína Peikertová, Daniela Plachá
Most of drugs are only slightly soluble in the circulatory system of the human body. This reduces the efficiency of their use and that is why new ways how to increase their solubility are investigated. One way to improve the solubility of the drug is to reduce its particle size. Conventional techniques such as crushing or grinding usually do not guarantee a narrow particle size distribution, which is required for pharmaceuticals. Application of supercritical fluids, especially of supercritical CO₂, seems to be convenient method for the preparation of pharmaceuticals submicron particles or nanoparticles...
May 1, 2019: Journal of Nanoscience and Nanotechnology
Zhiming Yan, Biqing Hu, Qianlian Li, Sunxian Zhang, Jie Pang, Chunhua Wu
In this work, covalent organic frameworks SNW-1 incorporated polyacrylonitrile (SNW-1@PAN) nanofiber was synthesized and used as pipette tip solid phase extraction (PT-SPE) adsorbent for preconcentration of five sulfonamides (SAs) in meat samples. The SNW-1@PAN nanofiber was fabricated via two steps, including the hydrothermal synthesis of SNW-1 and co-electrospinning of the SNW-1/PAN mixture. The three dimensional networks of electrospun nanofiber provide both low backpressure and rapid mass transfer in PT-SPE application, thus preventing the problems of high backpressure and leakage caused by directly packing SNW-1 into PT-SPE cartridge...
November 22, 2018: Journal of Chromatography. A
Eriko Kashihara, Kohei Fujita, Hiroshi Koyama, Tadashi Mio
Septic pulmonary embolism (SPE) is a rare condition, indicating bacteraemia. We report a rare case of Staphylococcus aureus bacteraemia causing SPE and multiple abscesses in a previously healthy patient. A previously healthy 33-year-old man presented to our hospital with fever and back pain for 3 weeks. Chest contrast-enhanced computed tomography image was suggestive of SPE, and the blood culture showed methicillin-susceptible S. aureus . Additional focus identification revealed pyogenic spondylitis and abscesses in the psoas muscles...
December 2018: Oxford Medical Case Reports
Susan Hurley, Debbie Goldberg, Miaomiao Wang, June-Soo Park, Myrto Petreas, Leslie Bernstein, Hoda Anton-Culver, David O Nelson, Peggy Reynolds
BACKGROUND: Per- and poly- fluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Their potential as breast carcinogens is unclear. Our objective was to evaluate the risk of breast cancer associated with serum PFAS concentrations in a nested case-control study within the California Teachers Study. METHODS: Participants were 902 women with invasive breast cancer (cases) and 858 with no such diagnosis (controls) who provided 10 mL of blood and were interviewed during 2011-2015, an average of 35 months after case diagnosis...
November 27, 2018: Environmental Health: a Global Access Science Source
Hongwei Wang, Jianeng Tan, Xianchao Shang, Xuan Zheng, Xinmin Liu, Jing Wang, Xiaodong Hou, Yongmei Du
Here, a porous organic cage (POC)-incorporated polymeric monolith was fabricated in a syringe through the introduction of the POC into poly(ethylene glycol dimethacrylate) monolith in a one-step traditional free-radical polymerization proceess. The resulting monolithic phases were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), nitrogen adsorption/desorption experiments and thermogravimetric analysis (TGA), which confirmed the successful incorporation of the POC in the monolithic matrix...
November 20, 2018: Journal of Chromatography. A
Mingzhang Gao, Min Wang, Barbara E Glick-Wilson, Jill A Meyer, Jonathan S Peters, Paul R Territo, Mark A Green, Gary D Hutchins, Hamideh Zarrinmayeh, Qi-Huang Zheng
The overexpression of P2X7R is associated with neuroinflammation and plays an important role in various neurodegenerative diseases. The [18 F]fluoropropyl derivative of GSK1482160, [18 F]IUR-1602, has been first prepared and examined as a new potential P2X7R radioligand. The reference standard IUR-1602 was synthesized from tert-butyl (S)-5-oxopyrrolidine-2-carboxylate, fluoropropylbromide, and 2-chloro-3-(trifluoromethyl)benzylamine with overall chemical yield 13% in three steps. The target tracer [18 F]IUR-1602 was synthesized from desmethyl-GSK1482160 with 3-[18 F]fluoropropyl tosylate, prepared from propane-1,3-diyl bis(4-methylbenzenesulfonate) and K[18 F]F/Kryptofix2...
November 16, 2018: Applied Radiation and Isotopes
Z N Kon, C Pasrija, G J Bittle, S Vemulapalli, M V Grau-Sepulveda, R Matsouaka, K B Deatrick, B S Taylor, J S Gammie, B P Griffith
BACKGROUND: There has been renewed interest in surgical pulmonary embolectomy (SPE) for the treatment of pulmonary embolism, but the real-world incidence and outcomes of SPE have yet to be well described using a large, granular dataset. We, therefore, examined the modern experience with SPE in North America as reported to the Society of Thoracic Surgery Adult Cardiac Surgery Database (STS ACSD). METHODS: The STS ACSD was queried for all isolated SPE for the treatment of acute pulmonary embolism (2011-2015)...
November 23, 2018: Annals of Thoracic Surgery
Rodrigo Rodrigues Gomes Costa, Frederico Ribeiro Neto
OBJECTIVES: The study aimed to test the cross-validation of a specific one maximum repetition (1RM) predictive equation based on the 4- to 12-maximum repetition test (4-12RM) for men with spinal cord injury (SCI). STUDY DESIGN: Cross-sectional study. SETTING: Rehabilitation Hospital Network. PARTICIPANTS: Fifty-eight men aged 31.9 (20.0-38.0) years (median and quartile) with SCI were enrolled in the study. INTERVENTIONS: None...
November 26, 2018: Journal of Spinal Cord Medicine
Dawei Chen, Hong Miao, Yunfeng Zhao, Yongning Wu
Recently, the phenomenon of acute poisoning events caused by glyphosate (GLY) had frequently occurred all over the world. The present work reported a simple liquid chromatography-high resolution mass spectrometry (LC-HRMS) method for direct determination of GLY and its metabolite aminomethylphosphonic acid (AMPA) in human urine by combining cold-induced phase separation (CIPS) with hydrophilic pipette tip solid-phase extraction (PTSPE). First, a urine sample was mixed with acetonitrile at a 80% concentration to precipitate proteins...
November 16, 2018: Journal of Chromatography. A
Minsu Park, Tae Seok Seo
An integrated microfluidic device, consisting of a solid-phase extraction (SPE) unit for metal ion pretreatment, a micropump, a micromixer, and a detachable graphene oxide quantum dot (GOQD) array chip was constructed for selective and sensitive detection of As3+ , Cd2+ , and Pb2+ . The entire process could be sequentially and automatically completed by actuating a pneumatic micropump. Effect of the pH for metal ion capture and pumping scheme for recovery efficiency were investigated on a chip. The ion As3+ , Cd2+ , and Pb2+ whose concentrations ranged from 10-2 µM to 102 µM were successfully recovered with high efficiency over 80%...
November 15, 2018: Biosensors & Bioelectronics
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