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Haldun Arpacı, Yaran Koban, Abdullah Tok, Abdullah Beyoğlu
OBJECTIVES: The aim of this study was to investigate whether severe preeclampsia (SPE) affects intraocular pressure (IOP) and ocular perfusion pressure (OPP). MATERIAL AND METHODS: This prospective and comparative study included 64 pregnant females, allocated into 2 groups as Group 1 (31 pregnant women with SPE) and Group 2 (33 normotensive pregnant women). IOP, systolic and diastolic blood pressure, OPP of all the subjects were measured after 20 weeks of gestation and prior to labor and medical therapy...
2018: Ginekologia Polska
Feudjio Ndemanou Yolande, Bhattacharyya Sayantan, Ghosh Paramita, Sarkar Deblina, Mouokeu Raymond Simplice, Tume B Christopher, Murmu Nabendu
Cancer is a disease resulting from the deregulation of cell growth control, caused by an interaction between dietary, genetic, and environmental risk factors. Melanoma accounts for about 4% of cancers diagnosed; however they represent 75% of skin cancer-related deaths, with the incidence and death rates having increased globally over the past few decades. Spondias cytherea is a plant from the family Anacardiaceae. Its usage in the treatment of wounds, sores, and burns is reported from several countries, but the anticancer effects of the fruit have not yet been studied...
2018: Journal of Environmental Pathology, Toxicology and Oncology
Ayemeh Bagheri Hashkavayi, Jahan Bakhsh Raoof
In this paper, we report the application of a reusable electrochemical aptasensor for detection of tryptophan by using [Fe(bpy)3 ](p-CH3 C6 H4 SO2 )2 as an electroactive indicator and based on the target-compelled aptamer displacement. The aptasensor fabricated by self-assembling the thiolated probe on the surface of graphite screen-printed electrode modified with gold nanoparticles/multiwalled carbon nanotubes and chitosan nanocomposite (AuNPs/MWCNTs-Chit/SPE). Afterward, Trp aptamer (Apt) immobilized on the modified electrode surface through hybridization...
October 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
Dongmei Jiang, Dizhe Wei, Liuqing Wang, Shuai Ma, Yuanfang Du, Meng Wang
One-step solid-phase extraction (SPE) using a multiwalled carbon nanotube (MWCNT) for simultaneous analysis of 21 mycotoxins, including nine trichothecenes, zearalenone (ZEN) and its derivatives, four aflatoxins, and two ochratoxins, in corn and wheat was developed. Several key parameters affecting the performance of the one-step SPE procedure-types of MWCNT, combinations with five sorbents (octadecylsilyl (C18 ), hydrophilic⁻lipophilic balance (HLB), mixed-mode cationic exchange (MCX), silica gel, and amino-propyl (NH₂)), and filling amounts of the MWCNTs-were thoroughly investigated...
October 10, 2018: Toxins
Zengwei Li, Chan Lei, Na Wang, Xiongli Jiang, Yue Zeng, Zhenzhen Fu, Likou Zou, Li He, Shuliang Liu, Xiaolin Ao, Kang Zhou, Shujuan Chen
In this study, an efficient, selective, and simple analytical method for the extraction of chloramphenicol (CAP) from food using magnetic molecularly imprinted polymers (MMIPs) as the solid-phase extraction (SPE) sorbent was successfully developed. MMIPs with varying ratios of methacrylic acid to acrylamide were prepared by suspension polymerization on the surface of double-bond-modified Fe3 O4 magnetic nanoparticles. Further, these MMIPs were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy, as well as using a vibrating sample magnetometer...
October 3, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Ningge Jian, Liangliang Qian, Chunmin Wang, Ruixian Li, Qian Xu, Jian Li
Core-shell polyaniline/polyacrylonitrile nanofibers mat (PANI/Pan NFsM) was prepared for extraction of hydrophilic non-steroidal anti-inflammatory drugs (NSAIDs) in environmental water. Superior adsorption and desorption performance of PANI/Pan NFsM was confirmed by both static and dynamic adsorption/desorption experiments. These properties proved PANI/Pan NFsM was a potentially efficient and fast solid phase extraction (SPE) adsorbent for NSAIDs. Under the optimized conditions, only 3 mg of PANI/Pan NFsM could easily extract eight target analytes in 10 mL of water sample without any pre-treatment, and the analytes retained on NFsM could be easily eluted by 500 μL of 1% acetic acid methanol for direct UPLC-MS/MS analysis...
September 26, 2018: Journal of Hazardous Materials
Luis Honda, Mercedes Becerra-Herrera, Pablo Richter
A method combining liquid chromatography with a dual-probe ultraspray electrospray ionization (ESI) source and time-of-flight high-resolution mass spectrometry (LC-ESI-TOF/MS) was developed for the simultaneous determination of four steroidal sex hormones, estrone (E1), 17β-estradiol (E2), 17α-ethinyl estradiol (EE2), and estriol (E3), as well as five of their hydroxylated metabolites, 2-hydroxyestrone (2-OHE1), 4-hydroxyestrone (4-OHE1), 16α-hydroxyestrone (16-OHE1), 2-hydroxyestradiol (2-OHE2), and 4-hydroxyestradiol (4-OHE2), in water samples in a short chromatographic run of 10 min...
October 10, 2018: Analytical and Bioanalytical Chemistry
Leticia Díez-Quijada, Remedios Guzmán-Guillén, Ana I Prieto Ortega, María Llana-Ruíz-Cabello, Alexandre Campos, Vítor Vasconcelos, Ángeles Jos, Ana M Cameán
Cyanotoxins are a large group of noxious metabolites with different chemical structure and mechanisms of action, with a worldwide distribution, producing effects in animals, humans, and crop plants. When cyanotoxin-contaminated waters are used for the irrigation of edible vegetables, humans can be in contact with these toxins through the food chain. In this work, a method for the simultaneous detection of Microcystin-LR (MC-LR), Microcystin-RR (MC-RR), Microcystin-YR (MC-YR), and Cylindrospermopsin (CYN) in lettuce has been optimized and validated, using a dual solid phase extraction (SPE) system for toxin extraction and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for analysis...
October 8, 2018: Toxins
Wei Liu, Ruya Wang, Fan Hu, Pinping Wu, Tao Huang, Meriem Fizir, Hua He
The co-adsorption of mixed nonionic surfactant and imidazolium-based ionic liquid, Triton X100 (TX100), with 1-cetyl-3-methylimidazolium bromide (C16 mimBr) adsorbed onto the surface of magnetic halloysite nanotubes (MHNTs) was used as an efficient adsorbent for simultaneous determination of amlodipine and nimodipine in urine. The designed adsorbent was characterized by TEM, TGA, FTIR, and DLS analysis methods. All the parameters that influence the extraction efficiency are optimized with the aid of response surface methodology (RSM)...
October 8, 2018: Analytical and Bioanalytical Chemistry
Margarita Kapsi, Charoula Tsoutsi, Anastasia Paschalidou, Triantafyllos Albanis
Estuarine environments are being constantly stressed by new sources of pollution (e.g. pesticides) derived from activities of industry and intensive agriculture. The present study aims at quantify pesticides of three different categories (fungicides, herbicides and insecticides) in the Louros River (Epirus region, North-Western Greece). A monitoring study of 34 compounds was carried out in surface river waters from June 2011 until May 2012. Seven water sampling stations were established and 35 water samples were collected...
September 15, 2018: Science of the Total Environment
Ester López-García, Nicola Mastroianni, Cristina Postigo, Damià Barceló, Miren López de Alda
This work presents a multi-residue method for the simultaneous determination of 37 legal and illicit psychoactive substances in wastewater, including the most common illicit drugs (cocaine-related compounds, amphetamine-type stimulants, hallucinogens, opiates/opioids, and cannabinoids), new psychoactive substances (two synthetic cathinones, the synthetic opioid AH-7921, and the arylcyclohexylamine methoxetamine), and legal but controlled psychoactive substances (stimulants, benzodiazepines, antidepressants, sedatives, antipsychotics, and hypnotics)...
September 18, 2018: Journal of Chromatography. A
Ju-Yeon Moon, Hye Suk Lee, Jun Ho Kim, Jin Hyup Lee, Man Ho Choi
Although, steroid profiling is being applied in clinical and biochemical studies, improvement of the technique is still needed for accurate quantification of steroids in case of limited biological sample volumes. To improve analytical sensitivity and selectivity in comparison to that of conventional methods, a method that comprises supported liquid extraction (SLE) and gas chromatography-mass spectrometry with a combination of selected-reaction and selected-ion monitoring modes (GC-SRM/SIM-MS) was developed...
December 11, 2018: Analytica Chimica Acta
Adam Wutkowski, Matthias Krajewski, Navratan Bagwan, Mathias Schäfer, Bhesh R Paudyal, Ulrich E Schaible, Dominik Schwudke
We characterized the performance of a micro-flow LC-ESI-MS2 approach to analyze lipid mediators (LMs) and polyunsaturated fatty acids (PUFA) that was optimized for SPE free lipid extraction. Tandem mass spectrometry was exclusively performed in parallel reaction monitoring (PRM) mode using TOF and Orbitrap analyzers. This acquisition strategy allowed in addition to quantitation by specific quantifier ions to perform spectrum comparisons using full MS2 spectra information of the analyte. Consequently, we developed a dedicated software SpeCS that allows to 1) process raw peak lists, 2) generate customized spectral libraries, 3) test specificity of quantifier ions and 4) perform spectrum comparisons...
December 11, 2018: Analytica Chimica Acta
Patrick Heinrich, Thomas Braunbeck
Microplastic particles (MPs) are emerging contaminants in aquatic environments, which are assumed to play a role as vectors for lipophilic pollutants, as the particles bear a potential for the accumulation of lipophilic contaminants from the water phase on the MPs' surface and subsequent release in contact with organisms. In an attempt to allow the bioanalytical detection and quantitatively estimate bioavailability of MP-bound pollutants under realistic conditions in vitro, a protocol was developed for water-based loading of lipophilic substances to MPs using a solid-phase extraction (SPE) approach and subsequent detection of the substances in a sensitivity-enhanced 7-ethoxyresorufin-O-deethylase (EROD) assay with RTL-W1 cells...
October 4, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Sandro Navickiene, Luis Fabrício Santana Santos, Alexandre Dos Reis Silva
Background: Pesticides are applied for pest control during the production of cereal grains used in beer production. Given the risks for consumers, it is important to analyze the pesticide residues. Objective: Quick, easy, cheap, effective, rugged, and safe (QuEChERS)-based methods are very effective, and improvement in the clean-up step is an important approach. Methods: Primary secondary amine (PSA) and magnesium silicate were evaluated for dispersive-solid-phase extraction (d-SPE) clean-up step in extracts provided by the QuEChERS method in combination with GC-tandem MS for the determination of acetamiprid, terburfos, alachlor, ametryn, atrazine, azoxystrobin, carbofuran, carbosulfan, cypermethrin, deltamethrin, difenoconazole, esfenvalerate, flutriafol, thiamethoxam, and parathion-methyl in lager beer...
October 5, 2018: Journal of AOAC International
Nahla A Abdelshafi, Jérémy Bell, Knut Rurack, Rudolf J Schneider
Quick but accurate testing and on the spot monitoring of cocaine in oral fluids and urine continues to be an important toxicological issue. In terms of drug testing, a number of devices were introduced into the market within the last decades, notably for workplace inspection or roadside testing. However, these systems did not always fulfill the requirements in terms of reliability, especially when low cut-off levels are required. With respect to surface water, the presence of anthropogenic small organic molecules such as prescription and over-the-counter pharmaceuticals as well as illicit drugs like cannabinoids, heroin or cocaine have become a challenge for scientists to develop new analytical tools for screening and on-site analysis because many of them serve as markers for anthropogenic input and consumer behaviour...
October 4, 2018: Drug Testing and Analysis
Li Zhang, Zhusheng Guo, Shujin Xie, Jing Zhou, Guiling Chen, Jianbo Feng, Ya Huang
Galactomannan (GM), 1,3-β-D-glucan (BDG) and aspergillus-lateral flow device (LFD) are recognized as diagnostic tools for invasive aspergillosis (IA). The combined performance of these assays, however, is inconsistent in various studies. We undertook a meta-analysis of 13 studies involving 1513 patients to evaluate the utility of GM in combination with BDG or LFD for diagnosing IA. The pooled SEN, SPE, PLR, NLR and diagnostic odds ratio (DOR) were calculated and constructed to summarize the overall combined performance...
August 18, 2018: Diagnostic Microbiology and Infectious Disease
Dieter Schemeth, Nikoline Juul Nielsen, Jan H Christensen
In this study, we focus on isolation and fractionation strategies by solid phase extraction (SPE) for a broad range of environmentally related organic acids. These emerging potential contaminants are primary degradation products of spilled petrogenic compounds but little attention has been given to their environmental analysis and risk assessment. Three mixed-mode anion exchange sorbents possessing various backbone polarities were compared with respect to the extraction and fractionation efficiency. Quantitative analysis was obtained using an optimized and validated LC-MS method...
December 14, 2018: Analytica Chimica Acta
Sajjad Molavipordanjani, Vladimir Tolmachev, Seyed Jalal Hosseinimehr
The presence of radiochemical impurities in a radiopharmaceutical contributes to an unnecessary radiation burden for the patients or to an undesirable high radioactivity background, which reduces the imaging contrast or therapeutic efficacy. Therefore, if the radiolabeling process results in unsatisfactory radiochemical purity, a purification step is unavoidable. A successful purification process requires a profound knowledge about the radiopharmaceuticals of interest ranging from structural features to susceptibility to different conditions...
September 29, 2018: Drug Discovery Today
Keiichi Fujiwara, Ryuzo Abe, Shin Yasui, Osamu Yokosuka, Naoya Kato, Shigeto Oda
AIM: Artificial liver support (ALS) system sustaining patients with acute liver failure (ALF) in good condition until recovery of the native liver or performance of liver transplantation (LT), is essential for the improvement of the poor prognosis of ALF despite the lack of survival benefit. We aimed to investigate the efficacy of various ALS systems for fulminant hepatitis (FH) performed in our liver unit so far, focusing on the restoration of consciousness from hepatic encephalopathy...
October 2, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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