Yi Wang, Tengda Chu, Ting Jin, Shengming Xu, Cheng Zheng, Jianmin Huang, Sisi Li, Lixia Wu, Jianliang Shen, Xiaojun Cai, Hui Deng
The treatment of diabetic periodontitis poses a significant challenge due to the presence of local inflammation characterized by excessive glucose concentration, bacterial infection, and high oxidative stress. Herein, mesoporous silica nanoparticles (MSN) are embellished with gold nanoparticles (Au NPs) and loaded with manganese carbonyl to prepare a carbon monoxide (CO) enhanced multienzyme cooperative hybrid nanoplatform (MSN-Au@CO). The Glucose-like oxidase activity of Au NPs catalyzes the oxidation of glucose to hydrogen peroxide (H2 O2 ) and gluconic acid,and then converts H2 O2 to hydroxyl radicals (•OH) by peroxidase-like activity to destroy bacteria...
April 22, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)