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https://www.readbyqxmd.com/read/30098560/impact-on-growth-oxidative-stress-and-apoptosis-related-gene-transcription-of-zebrafish-after-exposure-to-low-concentration-of-arsenite
#1
Wen-Qi Dong, Hong-Jie Sun, Yu Zhang, Hong-Jun Lin, Jian-Rong Chen, Hua-Chang Hong
Low concentrations of arsenic (As) contamination in aquatic environment is a worldwide issue, which is of great concern. To evaluate the impact of low concentrations of As on zebrafish, we measured the growth, antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), oxidative damage (malondialdehyde, MDA) and apoptosis-related genes (nrf2, p53 and c-jun) of adult zebrafish after exposing to different AsIII concentrations (0, 10, 50, 100 or 150 μg L-1 ) for 28 d. Results indicated that exposure to low AsIII concentrations decreased the zebrafish weight by 14%, increased the activities of SOD and CAT by 23-41% and 31-59%, decreased the contents of MDA by 29-54%, and modulated transcription of apoptosis related genes...
August 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/30098556/functional-and-structural-biomarkers-to-monitor-heavy-metal-pollution-of-one-of-the-most-contaminated-freshwater-sites-in-southern-europe
#2
Viviana Maresca, Lina Fusaro, Sergio Sorbo, Antonietta Siciliano, Stefano Loppi, Luca Paoli, Fabrizio Monaci, Elham Asadi Karam, Marina Piscopo, Marco Guida, Emilia Galdiero, Marilena Insolvibile, Adriana Basile
This study evaluated the biological effects of highly polluted freshwater environment (Regi Lagni channels, S Italy) on the aquatic moss Leptodictyum riparium, exposed in bags at three sites representative of different environmental conditions and characterized by different heavy metal burdens. Bioaccumulation, ultrastructural alterations, Reactive Oxygen Species (ROS) production, antioxidant enzymes activity and DNA damage were assessed. To better evaluate the biological response of the moss species to heavy metals, the same biological parameters were assessed also in L...
August 8, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30098507/leaf-shape-variation-as-a-potential-biomarker-of-soil-pollution
#3
Maria de la Paz Pollicelli, Yanina L Idaszkin, Rolando Gonzalez-José, Federico Márquez
Halophytic plants play a fundamental role in salt marshes, influencing their structure, dynamics, and cycling of nutrients and minerals. These plants have the ability to retain metals in the soil, or absorb and retain them in underground structures, or transport them to their aerial structures. Here we aim to study shape variation in the leaves of Cressa truxillensis inhabiting the salt marsh of San Antonio Oeste, according to their proximity to a source of metals in the soil. A gradient of bioavailability of metal was observed in the soil, decreasing from the site closest to the source to the most distant point, where Zn was the most abundant metal followed by Pb and Cu...
August 8, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30098444/effects-of-low-concentrations-copper-on-antioxidant-responses-dna-damage-and-genotoxicity-in-thick-shell-mussel-mytilus-coruscus
#4
Kaida Xu, Zurong Tang, Shuobo Liu, Zhi Liao, Hu Xia, Lianwei Liu, Zhongming Wang, Pengzhi Qi
For the aim to study potential detrimental effects induced by Cu exposure at low, environmentally relevant concentrations, the in vivo activities at different levels of biological organisations of thick shell mussel Mytilus coruscus exposed to two levels of copper were assessed. Cu-induced stresses were evaluated through antioxidant responses, DNA damage and genotoxicity. The results revealed significant higher SOD and CAT activities, and MDA concentration in haemocytes of M. coruscus with Cu exposure at 8 μg/L, while only significant accumulation in CAT activity with Cu exposure at 2 μg/L and no significant changes with SOD activity and MDA concentration at this level of Cu exposure...
August 8, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/30098389/8-3-phenylpropyl-1-3-7-triethylxanthine-is-a-synthetic-caffeine-substitute-with-stronger-metabolic-modulator-activity
#5
David F Carrageta, Tânia R Dias, Ivana Jarak, Marco G Alves, Pedro F Oliveira, Mietha M Van der Walt, Gisella Terre'Blanche, Mariana P Monteiro, Branca M Silva
Caffeine is one of the most worldwide consumed methylxanthines. It is well-known for its thermogenic and cell metabolism modulating effects. Based on methylxanthines' chemical structure, 8-(3-phenylpropyl)-1,3,7-triethylxanthine (PTX) is a novel adenosine antagonist with higher receptor affinity than caffeine. Therefore, we hypothesized that PTX metabolic effects could be stronger than those of caffeine. For that purpose, murine 3 T3-L1 cells were cultured in the presence of increasing doses of PTX or caffeine (0...
August 8, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/30098226/effects-of-sclerotic-changes-on-stress-concentration-in-early-stage-osteonecrosis-a-patient-specific-3d-finite-element-analysis
#6
Takeshi Utsunomiya, Goro Motomura, Satoshi Ikemura, Yusuke Kubo, Kazuhiko Sonoda, Hiroyuki Hatanaka, Shoji Baba, Koichiro Kawano, Takuaki Yamamoto, Yasuharu Nakashima
Stress distribution remains unclear in early-stage osteonecrosis of the femoral head (ONFH). To clarify this issue, we generated patient-specific finite element models (FEMs) from 51 patients with ONFH. Patients' hips were classified into three groups: ONFH without a sclerotic boundary (Stage 1, n = 6), ONFH with a sclerotic boundary (Stage 2, n = 10), and ONFH with both a sclerotic boundary and <2 mm collapse (Stage 3, n = 35). Four hips without ONFH were used as controls. Stress distribution in each FEM was compared with magnetic resonance imaging (MRI) and computed tomography (CT) results...
August 11, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30098127/the-effect-of-mandelonitrile-a-recently-described-salicylic-acid-precursor-on-peach-plant-response-against-abiotic-and-biotic-stresses
#7
Agustina Bernal-Vicente, Daniel Cantabella, José Antonio Hernández, Pedro Diaz-Vivancos
In a previous work, we observed that mandelonitrile (MD), which controls cyanogenic glycoside turnover, is involved in salicylic acid (SA) biosynthesis in peach plants. In order to gain knowledge about the possible roles of this SA biosynthetic pathway, this current study looks at the effect of MD and phenylalanine (MD precursor) treatments on peach plant performance from an agronomic point of view. Abiotic (2g/L NaCl) and biotic (Plum pox virus) stresses were assayed. We recorded the following chlorophyll fluorescence parameters: quantum yield of photochemical energy conversion in PSII [Y(II)], photochemical quenching (qP) and the quantum yield of regulated non-photochemical energy loss in PSII and its coefficient [Y(NPQ) and qN]...
August 10, 2018: Plant Biology
https://www.readbyqxmd.com/read/30097599/autophagy-upregulation-as-a-possible-mechanism-of-arsenic-induced-diabetes
#8
Marzieh Zeinvand-Lorestani, Heibatullah Kalantari, Mohammad Javad Khodayar, Ali Teimoori, Najmaldin Saki, Akram Ahangarpour, Fakher Rahim, Soheila Alboghobeish
The key features of type 2 diabetes mellitus (T2DM) caused by high fat diet (HFD) in combination with arsenic (As) exposure (pronounced glucose intolerance despite a significant decrease in insulin resistance) are different from those expected for T2DM. Autophagy has been considered as a possible link between insulin resistance and obesity. Therefore in this study, we utilized autophagy gene expression profiling via real-time RT-PCR array analysis in livers of NMRI mice exposed to an environmentally relevant and minimally cytotoxic concentration of arsenite (50 ppm) in drinking water while being fed with a HFD for 20 weeks...
August 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30097496/direct-comparison-of-cardiac-troponin-t-and-i-using-a-uniform-and-a-sex-specific-approach-in-the-detection-of-functionally-relevant-coronary-artery-disease
#9
Deborah Mueller, Christian Puelacher, Ursina Honegger, Joan E Walter, Patrick Badertscher, Nicolas Schaerli, Ivo Strebel, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Christina Hollenstein, Jeanne du Fay de Lavallaz, Raban Jeger, Christoph Kaiser, Damian Wild, Katharina Rentsch, Andreas Buser, Michael Zellweger, Tobias Reichlin, Christian Mueller
BCKGROUND: We aimed to directly compare high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) in the detection of functionally relevant coronary artery disease (fCAD). METHODS: Consecutive patients referred with clinical suspicion of fCAD and no structural heart disease other than coronary artery disease were included. The presence of fCAD was based on rest/stress myocardial perfusion single-photon emission computed tomography/computed tomography and coronary angiography...
August 10, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/30097472/whole-genome-sequencing-de-novo-assembly-and-phenotypic-profiling-for-the-new-budding-yeast-species-saccharomyces-jurei
#10
Samina Naseeb, Haya Alsammar, Tim Burgis, Ian Donaldson, Norman Knyazev, Christopher Knight, Daniela Delneri
Saccharomyces sensu stricto complex consist of yeast species, which are not only important in the fermentation industry but are also model systems for genomic and ecological analysis. Here, we present the complete genome assemblies of Saccharomyces jurei , a newly discovered Saccharomyces sensu stricto species from high altitude oaks. Phylogenetic and phenotypic analysis revealed that S. jurei is more closely related to S. mikatae , than S. cerevisiae , and S. paradoxus The karyotype of S. jurei presents two reciprocal chromosomal translocations between chromosome VI/VII and I/XIII when compared to the S...
August 10, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/30097282/endoplasmic-reticulum-stress-mediates-4-5-dichloro-2-n-octyl-4-isothiazolin-3-one-dcoit-induced-toxicity-and-liver-lipid-metabolism-changes-in-nile-tilapia-oreochromis-niloticus
#11
Yujie Su, Huifeng Li, Chang Xu, Xiaodan Wang, Jia Xie, Jian G Qin, Liqiao Chen, Erchao Li
DCOIT (4,5-dichloro-2-n-octyl-4-isothiazolin-3-one) is the main active ingredient in an emerging water environment antifoulant, the toxicity and environmental impacts of which need to be further investigated. Thus, this study examined the toxicity of DCOIT on Nile tilapia (Oreochromis niloticus), including its effects on behavior, respiration and energy metabolism as well as the role of endoplasmic reticulum stress (ER stress) in mediating its toxicity and metabolic changes. The changes in fish behavior, respiration, neuronal signal transmission, energy metabolism, ER stress, and liver histology were examined via acute (4 days) and chronic (28 days) exposures to 0, 3, 15, 30 μg/L DCOIT in vivo...
July 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/30097121/urtica-dioica-l-leaf-extract-modulates-blood-pressure-and-oxidative-stress-in-spontaneously-hypertensive-rats
#12
Una-Jovana Vajic, Jelica Grujic-Milanovic, Zoran Miloradovic, Djurdjica Jovovic, Milan Ivanov, Danijela Karanovic, Katarina Savikin, Branko Bugarski, Nevena Mihailovic-Stanojevic
BACKGROUND: Urtica dioica L. (Stinging nettle) has been used for centuries for the treatment of numerous health issues. PURPOSE: This study investigates the antioxidant capacity and the most abundant phenolic compounds of Urtica dioica L. leaf extract (UE), and its antihypertensive and antioxidative effects in vivo. STUDY DESIGN: Spontaneously hypertensive rats were supplemented with 10, 50, and 200 mg/kg/day of UE and 10 mg/kg/day of losartan during 4-week period...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30097046/comparison-of-mothers-and-grandmothers-physical-and-mental-health-and-functioning-within-6-months-after-child-nicu-picu-death
#13
JoAnne M Youngblut, Dorothy Brooten
BACKGROUND: Losing a child is devastating for parents and grandparents. Family and friends generally focus on comforting and supporting the bereaved parents, unintentionally ignoring the bereaved grandparents. Grandmothers and grandfathers often struggle with wanting to help their adult children (deceased child's parents) without usurping the parents' responsibilities and decisions regarding the deceased child. Research on mothers' and grandmothers' health at about the same time after the same child's death in the neonatal or pediatric intensive care unit is lacking...
August 10, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/30096688/bioaugmented-soil-aquifer-treatment-for-p-nitrophenol-removal-in-wastewater-unique-for-cold-regions
#14
Xi Zhang, Y S Yang, Ying Lu, Y J Wen, P P Li, Ge Zhang
P-nitrophenol (PNP) is a toxic and recalcitrant organic pollutant and a usual intermediate in the production of fine chemicals, which has posed a significant threat to subsurface environment safety. Soil aquifer treatment (SAT) is a promising method to remove and remediate contamination in vadose zone with low cost and high efficiency. However, there are still research gaps for the treatment of recalcitrant contaminants by SAT in cold regions, such as un-robust indigenous microbes and low temperature constraint in vadose zone...
August 4, 2018: Water Research
https://www.readbyqxmd.com/read/30096667/acesulfame-potassium-its-ecotoxicity-measured-through-oxidative-stress-biomarkers-in-common-carp-cyprinus-carpio
#15
Claudia Cruz-Rojas, Nely SanJuan-Reyes, María Paulina Aideé Gracia Fuentes-Benites, Octavio Dublan-García, Marcela Galar-Martínez, Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván
Acesulfame potassium (ACS) is a widely-used sweetener worldwide. Its presence has been demonstrated in diverse bodies of water. However, the deleterious effects this causes in aquatic organisms has not yet been identified, which generates controversy concerning the risks that ACS represents after its disposal into the bodies of water. Thus, the objective of this work was to evaluate if the exposure of ACS in environmentally-relevant concentrations was capable of producing oxidative stress in blood, liver, gill, brain and muscle of common carp (Cyprinus carpio)...
August 4, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30096572/the-metabolism-distribution-and-effect-of-dinotefuran-in-chinese-lizards-eremias-argus
#16
Yinghuan Wang, Yongtao Han, Yun Xie, Peng Xu, Wei Li
The Chinese lizards (Eremias argus) were used to evaluate the metabolism, distribution and effect of dinotefuran following oral exposed. The HPLC equipped with Q Exactive focus was used for metabolite identification and concentration analysis. After single oral administration, the time-concentration curves of dinotefuran and its metabolites were tissue-dependent. The liver and kidney were the major metabolic organs. Percutaneous and urinary excretions were the main ways for lizards to eliminate dinotefuran, and the urine output was the limiting factor...
August 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/30096478/effects-of-copper-on-hemocyte-parameters-in-the-estuarine-oyster-crassostrea-rivularis-under-low-ph-conditions
#17
Xizhi Huang, Xiaoyu Jiang, Meng Sun, Sam Dupont, Wei Huang, Menghong Hu, Qiongzhen Li, Youji Wang
With the development of industry and agriculture, the metal pollutants (e.g., Cu) are inevitably released into the aquatic environment. In addition, ocean acidification (OA) as a major environmental stress is affecting marine organisms. In this study, we investigated the hemocyte responses of the estuarine oyster Crassostrea rivularis exposed to six combinations of two pH levels (8.1 and 7.7) and three Cu concentrations (0, 10 and 50 μg/l) using flow cytometry in vitro and in vivo. In both experiments, Cu and low pH jointly affected the hemocyte parameters of oyster...
August 2, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/30096457/comparative-transcriptome-analysis-of-genes-involved-in-na-transport-in-the-leaves-of-halophyte-halogeton-glomeratus
#18
Juncheng Wang, Baochun Li, Lirong Yao, Yaxiong Meng, Xiaole Ma, Yong Lai, Erjing Si, Panrong Ren, Ke Yang, Xunwu Shang, Huajun Wang
Compartmentalization of Na+ into vacuoles is considered to be the most critical aspect of salt tolerance in H. glomeratus, an annual, succulent halophyte. Previous analysis of transcriptome involved in the H. glomeratus salt stress response relied on next-generation sequencing technologies that limit the capture of accurately spliced, full-length isoforms. To gain deeper insights into its salt stress response, we used the H. glomeratus Iso-Seq transcriptome database as a reference, and subsequent next-generation sequencing was subjected to various NaCl concentrations of leaves from plants revealed 115 upregulated and 87 downregulated differentially expressed isoforms (core DEIs)...
August 7, 2018: Gene
https://www.readbyqxmd.com/read/30096432/the-autophagic-response-to-oxidative-stress-in-osteoarthritic-chondrocytes-is-deregulated
#19
Andreas Goutas, Christina Syrrou, Ioanna Papathanasiou, Aspasia Tsezou, Varvara Trachana
It has been reported that oxidative stress (OS) is involved in the pathogenesis of osteoarthritis (OA) and that defective autophagy is accompanying this age-related disease. Moreover, it has been proposed that induction of autophagy could serve as therapeutic mean, as it was shown to alleviate several symptoms in OA animal models. On the contrary, it is also known that autophagic death, which results from over-activation of autophagy, is also a contributor in the development of this disease. Given this discrepancy, in this study we aimed at analysing the autophagic response against acute exogenous oxidative insult of chondrocytes from healthy individuals (control) and OA patients (OA)...
August 7, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30096396/pioglitazone-inhibits-advanced-glycation-induced-protein-modifications-and-down-regulates-expression-of-rage-and-nf-%C3%AE%C2%BAb-in-renal-cells
#20
Krishna A Adeshara, Sanskruthi B Agrawal, Sushama M Gaikwad, Rashmi S Tupe
The present work aims to determine the effect of pioglitazone on in-vitro albumin glycation and AGE-RAGE induced oxidative stress and inflammation. Bovine serum albumin was glycated by methylglyoxal in absence or presence of pioglitazone. Glycation markers (fructosamine, carbonyl groups, β-amyloid aggregation, thiol groups, bilirubin binding capacity and AOPP); protein conformational changes (native-PAGE and HPLC analysis) were determined. Cellular study was done by estimating antioxidants, ROS levels, expression profile of membrane RAGE, NF-κB and levels of inflammatory cytokines (IL-6, TNF-α) using HEK-293 cell line...
August 7, 2018: International Journal of Biological Macromolecules
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