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carcinoma of bile duct

Yuhki Sakuraoka, Takashi Suzuki, Genki Tanaka, Takayuki Shimizu, Takayuki Shiraki, Park Kyongha, Shozo Mori, Yukihiro Iso, Masato Kato, Taku Aoki, Keiichi Kubota, Hidetsugu Yamagishi
INTRODUCTION: Cystic duct carcinoma is a rare disease, and only 33 cases reported worldwide have completely fulfilled the criteria first established by Farrar in 1951. Here we describe an extremely rare case of early cystic duct carcinoma that fulfilled the Farrar criteria, the papillary tumour protruding into the common bile duct, leading to obstructive jaundice. CASE PRESENTATION: A 76-year-old man visited a clinic with icteric conjunctivae, and was referred to our hospital for investigation of suspected obstructive jaundice...
October 4, 2018: International Journal of Surgery Case Reports
Malene Theilmann Thinesen, Ove B Schaffalitzky de Muckadell, Sönke Detlefsen
IgG4-related disease is characterized by lymphoplasmacytic inflammation and fibrosis, often leading to mass-forming lesions in different organs. When IgG4-related disease affects the bile ducts, it is called IgG4-related sclerosing cholangitis. A 74-year-old male complained of dysphagia and abdominal pain. Endoscopic retrograde cholangiography and magnetic resonance cholangiography revealed bile duct changes suspicious of a bile duct carcinoma or cholangitis. Liver biopsy showed storiform fibrosis, lymphoplasmacytic infiltration, obliterative phlebitis, and a portal-based inflammatory nodule with expansion of a portal tract...
2018: Case Reports in Pathology
Nao Shimada, Shiro Miwa, Takuma Arai, Noriyuki Kitagawa, Shingo Akita, Nobuyoshi Iinuma, Keiko Ishii
INTRODUCTION: Pancreatic mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor. We report herein a case of pancreatic MANEC with cystic features. PRESENTATION OF CASE: A 67-year-old woman presented with jaundice. A CT scan revealed an 18-mm mass at the pancreatic head that obstructed the common bile duct and another 35-mm cystic lesion containing a mural nodule in the pancreatic body, which was suspected to be an intraductal papillary mucinous carcinoma. A biopsy of the head mass led to the diagnosis of adenocarcinoma...
September 23, 2018: International Journal of Surgery Case Reports
Xue-Min Liu, Yu Li, Jun-Xi Xiang, Feng Ma, Qiang Lu, Yan-Guang Guo, Xiao-Peng Yan, Bo Wang, Xu-Feng Zhang, Yi Lv
BACKGROUND: Magnetic anastomosis has been attempted in biliary and intestinal reconstruction. The objective of the current study was to introduce an initial clinical use of magnetic compression anastomosis for pancreaticojejunostomy and biliojejunostomy in Whipple's procedure. METHODS: Patients with peri-ampullary carcinoma and dilated bile and pancreatic ducts were prospectively enrolled from 2016 to 2017. After pancreaticoduodenectomy, an appropriate mother magnet and drainage tube was placed in the proximal bile duct and pancreatic duct...
October 2, 2018: Journal of Gastroenterology and Hepatology
Jiansheng Wang, Qingli Li
Liver cancer has one of the highest rates of human morbidity and mortality. However, in terms of pathology, liver cancer is traditionally clinically diagnosed based on observation of microscopic images of pathological liver sections. This paper investigates in vitro samples of rat models of bile duct carcinoma and presents a quantitative analysis method based on microscopic hyperspectral imaging technology to evaluate liver cancers at different stages. The example-based feature extraction method used in this paper mainly includes two algorithms: a morphological watershed algorithm is applied to find object and segment pathological components of pathological liver sections at different stages, and a support vector machine algorithm is implemented for liver tumor classification...
October 2018: Journal of Biomedical Optics
Katsuya Yamada
Glucose, one of the most fundamental sugar elements, has either D- or L-conformation. Of these, most cells preferentially take up D-glucose as an essential energy/carbon source. Such stereoselective uptake of glucose has been explored by fluorophore-bearing D- and L-glucose analogues. 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG), the most widely used fluorescent D-glucose analogue, was abundantly taken up into living Escherichia coli cells, whereas no detectable uptake was obtained for 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-L-glucose (2-NBDLG), the antipode of 2-NBDG developed as a fluorescent L-glucose analogue (fLG)...
2018: Biological & Pharmaceutical Bulletin
Myunghee Kang, Na Rae Kim, Dong Hae Chung, Hyun Yee Cho, Yeon Ho Park
We report a rare case of hilar squamous cell carcinoma. A 62-year-old Korean woman complaining of nausea was referred to our hospital. Her biliary CT revealed a 28-mm-sized protruding solid mass in the proximal common bile duct. The patient underwent left hemihepatectomy with S1 segmentectomy and segmental excision of the common bile duct. Microscopically, the tumor was a moderately differentiated squamous cell carcinoma of the extrahepatic bile duct, without any component of adenocarcinoma or metaplastic portion in the biliary epithelium...
October 1, 2018: Journal of Pathology and Translational Medicine
Byung-Kwan Jeong, You Na Sung, Sung Joo Kim, Soyeon An, Hosub Park, Hee Sang Hwang, Hyo Jeong Kang, Jae Hoon Lee, Ki-Byung Song, Kyu-Pyo Kim, Dae Wook Hwang, Sang Soo Lee, Song Cheol Kim, Seung-Mo Hong
Identifying the accurate origin of periampullary cancers is important, because different origins may trigger different clinicopathologic behaviors. The presence of intraepithelial precursor lesions, including high-grade pancreatic intraepithelial neoplasias (PanINs) and/or high-grade biliary intraepithelial neoplasias (BilINs), may be suggestive of the origin of the periampullary carcinoma in challenging cases. To prove the usefulness of high-grade intraepithelial precursor lesions to identify the origin of ambiguous periampullary cancers, the status and grades of PanINs and BilINs were evaluated in 256 periampullary carcinomas with a well-defined cancer origin as a test set, including 114 pancreatic cancers, 82 distal bile duct cancers, 54 ampullary cancers, and 6 duodenal cancers, and 112 periampullary carcinomas with clinically equivocal epicenter either by radiologic imaging used as a validation set...
September 24, 2018: Human Pathology
David Fernández-Ramos, Pablo Fernández-Tussy, Fernando Lopitz-Otsoa, Virginia Gutiérrez-de-Juan, Nicolás Navasa, Lucía Barbier-Torres, Imanol Zubiete-Franco, Jorge Simón, Agustín F Fernández, Ander Arbelaiz, Ana M Aransay, José Luis Lavín, Naiara Beraza, María J Perugorria, Jesus M Banales, Erica Villa, Mario F Fraga, Juan Anguita, Matias A Avila, Carmen Berasain, Paula Iruzibieta, Javier Crespo, Shelly C Lu, Marta Varela-Rey, José M Mato, Teresa C Delgado, María L Martínez-Chantar
Glycine N-methyltransferase (GNMT) is the most abundant methyltransferase in the liver and a master regulator of the transmethylation flux. GNMT downregulation leads to loss of liver function progressing to fibrosis, cirrhosis, and hepatocellular carcinoma. Moreover, GNMT deficiency aggravates cholestasis-induced fibrogenesis. To date, little is known about the mechanisms underlying downregulation of GNMT levels in hepatic fibrosis and cirrhosis. On this basis, microRNAs are epigenetic regulatory elements that play important roles in liver pathology...
September 20, 2018: Cell Death & Disease
Jae Hyuck Jun, Sung Koo Lee, So Yeon Kim, Dong Hui Cho, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Dong-Wan Seo, Myung-Hwan Kim
BACKGROUND/OBJECTIVES: The pancreatoduodenal groove (anatomical groove) is a potential space bordered by the head of the pancreas, duodenum, and common bile duct. Discerning between groove carcinoma (GC) and groove pancreatitis (GP) is often difficult, but clinically important. We retrospectively analyzed and compared the findings of computed tomography (CT), laboratory tests, and endoscopic ultrasound-fine needle aspiration (EUS-FNA) for GC and GP. METHODS: GC (n = 36) and GP (n = 44) patients at Asan Medical Center from January 1, 2000, to May 31, 2017 were retrospectively reviewed...
October 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Daria Maccora, Daniela Di Giuda, Francesca Romana Ponziani, Maurizio Pompili, Venanzio Valenza
A 47-year-old man, with a history of anabolic steroid abuse, developed hepatic adenomatosis and multifocal hepatocellular carcinoma. He underwent ultrasound and CT follow-up, showing multiple solid and fluid hepatic lesions. Consequently, hospitalization was required because of high fever (up to 39°C), weakness, and anorexia. An abdominal CT scan revealed an enlargement of one of the intrahepatic fluid collections. Biochemical and microbiological analyses of a fluid sample showed bilirubin and bile acids as well as Streptococcus cristatus and Enterobacter cloacae...
November 2018: Clinical Nuclear Medicine
Yingjun Xie, Yien Xiang, Dan Zhang, Xiaoxiao Yao, Jiyao Sheng, Yongsheng Yang, Xuewen Zhang
Sarcomatoid carcinoma (SC) is an extremely rare and complicated malignant neoplasm that consists of both malignant epithelial components and atypical spindle cells that express an epithelial phenotype. The presents study reported a case of SC of the pancreas (SCP), along with a brief review of the literature. A 63‑year‑old man was admitted to The Second Hospital of Jilin University hospital with complaints of epigastralgia and jaundice of one month in duration. Based on preoperative laboratory blood tests and radiography, a mass at the distal common bile duct was suspected...
September 14, 2018: Molecular Medicine Reports
Dong-Sik Kim, Bong-Wan Kim, Etsuro Hatano, Shin Hwang, Kiyoshi Hasegawa, Atsushi Kudo, Shunichi Ariizumi, Masaki Kaibori, Takumi Fukumoto, Hideo Baba, Seong Hoon Kim, Shoji Kubo, Jong Man Kim, Keun Soo Ahn, Sae Byeol Choi, Chi-Young Jeong, Yasuo Shima, Hiroaki Nagano, Osamu Yamasaki, Hee Chul Yu, Dai Hoon Han, Hyung-Il Seo, Il-Young Park, Kyung-Sook Yang, Masakazu Yamamoto, Hee-Jung Wang
OBJECTIVE: To identify optimal surgical methods and the risk factors for long-term survival in patients with hepatocellular carcinoma accompanied by macroscopic bile duct tumor thrombus (BDTT). SUMMARY BACKGROUND DATA: Prognoses of patients with hepatocellular carcinoma accompanied by BDTT have been known to be poor. There have been significant controversies regarding optimal surgical approaches and risk factors because of the low incidence and small number of cases in previous reports...
September 13, 2018: Annals of Surgery
Toshikatsu Nitta, Jun Kataoka, Masato Ohta, Kensuke Fujii, Yuko Takashima, Yoshihiro Inoue, Takashi Ishibashi
Purpose: This paper presents an overview of the surgical strategy for patients with suspected gallbladder carcinoma (GBC), including incidental GBC cases, preoperatively or intraoperatively, as well as their outcomes. Methods: Between April 2009 and December 2017, 529 patients underwent cholecystectomy for gallbladder disease at our hospital. Both intraoperative and postoperative histological examinations of the excised gallbladder facilitated the diagnosis of GBC...
September 2018: Annals of Medicine and Surgery
Siyuan Yao, Kojiro Taura, Yukihiro Okuda, Yuzo Kodama, Norimitsu Uza, Naoki Gouda, Sachiko Minamiguchi, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
BACKGROUND: The effect of endoscopic transpapillary mapping biopsy (MB) on decision-making of surgical indications, selecting surgical procedures, or operative outcomes remains unclear. METHODS: Two-hundred and thirty-four patients with cholangiocarcinoma who were evaluated for surgical resection from 2007 to 2017 were reviewed. MB was performed in 80 patients who underwent tumor resection. We examined how MB affected operative indications or modified surgical procedures...
September 9, 2018: Journal of Surgical Oncology
Da Hye Kim, Byeong Nam Im, Hee Sook Hwang, Kun Na
To improve the therapeutic efficacy of gemcitabine (GEM) as an anticancer drug for bile duct cancer, GEM-loaded liposomes (GDPPL) prepared from a photosensitizer-conjugated lipid were investigated regarding the drug release kinetics, photodynamic therapy (PDT) efficacy, and immunomodulatory effects. The release rate of GEM from the liposomes was improved approximately 2-fold compared to non-laser irradiation groups due to lipid disruption by reactive oxygen species produced from the activated photosensitizer upon laser irradiation...
August 23, 2018: Biomaterials
Meng-Shin Shiao, Khajeelak Chiablaem, Varodom Charoensawan, Nuttapong Ngamphaiboon, Natini Jinawath
Intrahepatic cholangiocarcinoma (ICC) is the cancer of the intrahepatic bile ducts, and together with hepatocellular carcinoma (HCC), constitute the majority of primary liver cancers. ICC is a rare disorder as its overall incidence is < 1/100,000 in the United States and Europe. However, it shows much higher incidence in particular geographical regions, such as northeastern Thailand, where liver fluke infection is the most common risk factor of ICC. Since the early stages of ICC are often asymptomatic, the patients are usually diagnosed at advanced stages with no effective treatments available, leading to the high mortality rate...
2018: Frontiers in Genetics
Hai-Jie Hu, Zhen-Ru Wu, Yan-Wen Jin, Wen-Jie Ma, Qin Yang, Jun-Ke Wang, Fei Liu, Fu-Yu Li
BACKGROUND: Hilar cholangiocarcinoma (HCCA) occurs in the core section of the biliary system and has a strong tendency to broadly invade the surrounding vascular system, perineural tissue and major liver parenchyma. Thus, minimally invasive resection can only be achieved in limited cases. This article reviews the current laparoscopic and robotic surgery techniques for HCCA and analyses the difficulties and limitations of the current minimally invasive surgical techniques for HCCA. METHODS: A systematic literature search was conducted using multiple electronic databases...
August 22, 2018: ANZ Journal of Surgery
Xinwei Yang, Zhiquan Qiu, Rongzhen Ran, Longjiu Cui, Xiangji Luo, Mengchao Wu, Wei-Feng Tan, Xiaoqing Jiang
There is not yet a consensus regarding a difference in prognosis for patients with hepatocellular carcinoma (HCC) with and without bile duct invasion (BDI). The present study aimed to clarify the prognostic importance of BDI on the short and long-term outcome of patients with HCC who underwent surgical resection. The present study evaluated HCC with BDI, including peripheral microscopic biliary invasion and revealed that the prognosis of patients with BDI was poorer compared with those without BDI. It should be noted that peripheral BDI also had a negative impact on the prognosis of patients with HCC...
September 2018: Oncology Letters
Heshu Sulaiman Rahman
Background: The mastic gum resin has been used in traditional Kurdish medicine for treating various disorders such as topical wound and gastric ulcer. The study designed to evaluate the total polyphenol and flavonoid content, free radical scavenging activity, and anticancer effects of mastic gum resin derived from Pistacia atlantica subspecies kurdica. Materials and methods: Folin -Ciocalteau and the aluminum chloride colorimetric assays were used to determine the total phenol and flavonoid contents in the mastic gum resin respectively...
2018: OncoTargets and Therapy
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