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https://www.readbyqxmd.com/read/30546838/the-multikinase-inhibitor-regorafenib-decreases-angiogenesis-and-improves-portal-hypertension
#1
Frank Erhard Uschner, Florian Schueller, Ivelina Nikolova, Sabine Klein, Robert Schierwagen, Fernando Magdaleno, Stefanie Gröschl, Sven Loosen, Thomas Ritz, Christoph Roderburg, Michael Vucur, Glen Kristiansen, Twan Lammers, Tom Luedde, Jonel Trebicka
Background and Aims: Angiogenesis is critically involved in the development of liver fibrosis, portal hypertension (PHT) and hepatocellular carcinoma (HCC). Regorafenib is a novel second-line therapy for HCC, but might also be beneficial in fibrosis and PHT even in absence of HCC. This study investigated the effects of regorafenib in experimental models without HCC. Methods: Fibrosis ( in vivo and in vitro ), inflammation, liver damage (aminotransferases), angiogenesis (matrigel implantation) and in vivo systemic and portal hemodynamics were assessed in different mouse and rat models (bile duct ligation, CCl4 , partial portal vein ligation) after acute and chronic treatment with regorafenib...
November 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/30546416/rare-case-of-idiopathic-sclerosing-cholangitis-which-was-difficult-to-distinguish-from-cholangiocarcinoma-a-case-report
#2
Shunsuke Shichi, Takahiro Einama, Mayu Suzuki, Hiroki Matsui, Ryo Kanazawa, Kazuaki Shibuya, Takashi Suzuki, Fumihiko Matsuzawa, Kohei Nakachi, Taku Hashimoto, Nobuo Kondo, Hironori Abe, Akinobu Taketomi
It is often difficult to correctly diagnose patients who present with dilation of the bile duct. Cholangiocarcinoma, primary sclerosing cholangitis (PSC) and immunoglobulin (Ig)G4-related sclerosing cholangitis must be considered as potential diagnoses for these cases. The current study presents a 73-year-old female patient who presented with a high fever and abdominal pain. Contrast-enhanced computed tomography and magnetic resonance cholangiopancreatography revealed stenosis and dilation of the intrahepatic bile duct without solid components...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30541499/single-stranded-dna-binding-protein-2-expression-is-associated-with-patient-survival-in-hepatocellular-carcinoma
#3
Hyunsung Kim, Yeseul Kim, Yumin Chung, Rehman Abdul, Jongmin Sim, Hyein Ahn, Su-Jin Shin, Seung Sam Paik, Han Joon Kim, Kiseok Jang, Dongho Choi
BACKGROUND: SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppressive role of SSBP2, which is silenced by promoter hypermethylation in several human malignancies, such as hematologic malignancies, prostate cancer, esophageal squamous cell carcinoma, ovarian cancer, and gallbladder cancer. However, an oncogenic role of SSBP2 has been suggested in glioblastoma patients...
December 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30536097/culture-system-of-bile-duct-like-cystic-structures-derived-from-human-inducible-pluripotent-stem-cells
#4
Akihide Kamiya, Kazuya Anzai, Kota Tsuruya, Hiromi Chikada
Inducible pluripotent stem (iPS) cells are multipotent stem cells that are produced by gene transfer of reprogramming factors to somatic cells. They are thought to be an important source of regenerative medicine because of their pluripotency and self-renewal ability. Although the liver has high regeneration ability, continuous death of hepatocytes due to chronic inflammation leads to liver cirrhosis and liver carcinoma. With regard to such serious liver diseases, liver transplantation is used as a complete cure, but there is a problem of donor shortage...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30508395/application-of-real-time-contrast-enhanced-ultrasound-in-differential-diagnosis-of-liver-malignancies
#5
Hongling Li, Jin Li
OBJECTIVE: To evaluate the value of real time contrast-enhanced ultrasound in differential diagnosis of malignant liver tumors. METHODS: 60 patients pathologically diagnosed with liver cancer from May 2016 to May 2017 were selected as the objects. All patients received ultrasonic diagnosis followed by the observation on dynamic contrast enhancement of the image and the analysis on perfusion characteristics and difference in contrast-enhanced ultrasound results in patients with different types of liver cancer...
December 3, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30505587/brain-metastasis-and-herniation-in-a-patient-with-ampullary-adenocarcinoma-presenting-with-jaundice-and-memory-loss-case-report
#6
Abdullah Saleh ALQattan, Omar Ali Al-Ghamdi, Mumtaz Sarang, Mohammed Saad Al-Qahtani
Periampullary carcinoma includes neoplasms arising from head of pancreas, distal common bile duct, duodenum and ampulla of Vater. We report a case of a 41-year-old male, medically free who presented to our hospital as a case of obstructive jaundice, weight loss, headache and blurred vision. Clinical evaluation revealed memory loss and ataxia. Endoscopic retrograde cholangiopancreatography (ERCP) was carried out and showed a mass in the ampullary area, histopathology showed ampullary adenocarcinoma. Metastatic work up was carried out which revealed two brain metastatic lesions and multiple intra-abdominal metastasis...
October 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30466038/a-case-report-feasibility-of-a-near-infrared-ray-vision-system-photo-dynamic-eye%C3%A2-for-the-postoperative-ischemic-complication-of-gallbladder-carcinoma
#7
Koichiro Sakata, Daiki Kijima, Takashi Furuhashi, Katsuhiko Morita, Toshihiko Abe
INTRODUCTION: Radical resection with or without preserving extra-hepatic bile duct has shown similar prognoses for gallbladder carcinoma (GB ca), although aggressive resection is essential. In preserving bile duct, ischemic complications are serious, life-threatening serious problems. Correct evaluation of the blood flow to the biliary tract is crucial. CASE PRESENTATION: A case of gallbladder ca in a 62-year-old man was reported. The patient was diagnosed with stage Ⅱ GB ca (T2, N0, M0) by ultrasonography, computed tomography, magnetic resonance imaging, and endoscopic ultrasonography...
November 13, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30431594/ct-diagnosis-for-metastasis-of-clear-cell-renal-cell-carcinoma-to-the-pancreas-three-case-reports
#8
Qian Yu, Fanggong Kan, Zhoupeng Ma, Tianke Wang, Guansheng Lin, Bingye Chen, Wenliang Zhao
RATIONALE: Clear cell renal cell carcinoma (CCRCC) metastasis to pancreas is clinically rare. Misdiagnosis for these cases is frequently due to the low incidence, lack of specific clinical symptoms, and laboratory results. PATIENT CONCERNS: Three female patients aged 47 years, 69 years, and 76 years, respectively, were admitted to hospital for routine examination after resection of clear cell carcinoma of kidney for 69 months, 57 months, and 123 months, respectively...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30430195/-radiologic-diagnosis-of-the-gallbladder-and-bile-ducts-part-2-acute-and-chronic-cholecystitis-primary-sclerosing-cholangitis-psc-benign-and-malignant-masses-of-the-biliary-system
#9
H Helmberger, B Kammer
Upper abdominal pain, icterus and cholestasis are the symptoms leading to evaluation of the biliary tract. Together with its complications biliary stone disease is the main reason for inflammation of the biliary system. A distinction is made between acute and chronic variants. In chronic bile duct inflammation primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC) and more recently IgG4-associated sclerosing cholangitis are of particular importance. Besides benign and tumor-like-lesions, malignant entities as gallbladder carcinoma and cholangiocarcinoma (CCC) in its three locations have to be mentioned...
November 14, 2018: Der Radiologe
https://www.readbyqxmd.com/read/30409114/pancreatic-acinar-cell-carcinoma-case-report-and-literature-review
#10
Zhang Xing-Mao, Zhang Hong-Juan, Li Qing, He Qiang
BACKGROUND: Pancreatic acinar cell carcinoma (ACC) is a rare tumor that constitutes 1% of all pancreatic neoplasms. Pancreatic ACC has unique characteristics in terms of biological behavior, imaging and prognosis. CASE PRESENTATION: The present study reported two cases of pancreatic ACC confirmed by postoperative pathology and both cases exhibited several different imaging features and laboratory test results. Both cases had approximately 4 cm mass located in uncinate process of pancreas...
November 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30401359/cost-analysis-and-determinants-of-living-donor-liver-transplantation-in-taiwan
#11
L-M Lin, S-C Kuo, Y-C Chiu, H-F Lin, M-L Kuo, A M Elsarawy, C-L Chen, C-C Lin
BACKGROUND: Liver transplantation (LT) has become established therapy for end-stage liver disease and small-cell hepatocellular carcinoma (HCC), relying mainly on living donor LT (LDLT) in Taiwan. The cost of LDLT varies in different countries depending on the insurance system, the costs of the facility, and staff. In this study we aimed to investigate cost outcomes and determinants of LDLT in Taiwan. METHODS: From January 2014 to December 2015, 184 LDLT patients were enrolled in a study performed at the Kaohsiung Chang Gung Memorial Hospital...
November 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30397857/synchronous-adeno-squamous-carcinoma-of-gallbladder-and-adenocarcinoma-of-common-bile-duct-twin-trouble
#12
Vaibhav Kumar Varshney, Meenakshi Rao, Subhash Chandra Soni, Binit Sureka
No abstract text is available yet for this article.
November 6, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/30390490/a-resected-case-of-hepato-pancreaticoduodenectomy-for-widely-extended-cholangiocarcinoma-undergoing-previous-intra-abdominal-poly-surgery
#13
Atsushi Nanashima, Naoya Imamura, Masahide Hiyoshi, Koichi Yano, Takeomi Hamada, Teru Chiyotanda, Kenzo Nagatomo, Rouko Hamada, Hiroshi Ito
INTRODUCTION: This case report describes a successful radical operation for a patient with extensive advanced cholangiocarcinoma who had previously undergone intra-abdominal poly-surgery for advanced gall bladder carcinoma. Careful diagnosis to define the adequate division of the right hepatic duct was performed, and the operation was completed without postoperative complications. CASE PRESENTATION: A 61-year-old woman was admitted to a hospital for obstructive jaundice, and extra-hepatic cholangiocarcinoma was found...
October 26, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30389302/outcomes-of-surgery-for-2010-who-classification-based-intraductal-papillary-neoplasm-of-the-bile-duct-case-control-study-of-a-single-japanese-institution-s-experience-with-special-attention-to-mucin-expression-patterns
#14
Fumi Harada, Ryusei Matsuyama, Ryutaro Mori, Takafumi Kumamoto, Daisuke Morioka, Masataka Taguri, Shoji Yamanaka, Itaru Endo
INTRODUCTION: The World Health Organization (WHO) proposed an integrated classification for intraductal papillary neoplasm of the bile duct (IPNB) in 2010. However, IPNB reportedly shows considerable geographic variation. This Japanese single-institution study examined outcomes of surgery for IPNB and the prognostic impact of immunohistochemical mucin expression patterns. MATERIALS AND METHODS: Patients with IPNB were identified from 413 patients who underwent curative-intent surgery for biliary tract (excluding gallbladder) neoplasms from 1992 to 2016 by retrospective macro- and microscopic reevaluation of resected specimens...
October 24, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30384995/regulation-of-periostin-expression-by-notch-signaling-in-hepatocytes-and-liver-cancer-cell-lines
#15
Pornrat Kongkavitoon, Patcharavadee Butta, Anapat Sanpavat, Pattarasinee Bhattarakosol, Pattarin Tangtanatakul, Benjawan Wongprom, Pisit Tangkijvanich, Nattiya Hirankarn, Tanapat Palaga
Notch signaling is involved in both differentiation of hepatocyte progenitors and hepatocellular carcinoma (HCC). The mechanism whereby Notch signaling regulates cellular transformation in hepatocytes is still controversial. This study investigated the impact of overexpressing truncated intracellular Notch1 (NICD1) on transcriptomic profiles of immortalized human hepatocytes. RNA sequencing and gene ontology enrichment analysis revealed that extracellular matrix organization and hyaluronan biosynthesis process gene sets are among those affected by Notch hyperactivation...
November 30, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30371587/use-of-18f-fdg-pet-ct-for-the-evaluation-of-carcinoma-arising-from-choledochal-cysts
#16
Qiao He, Linqi Zhang, Bing Zhang, Xiangsong Zhang
Choledochal cysts are rare congenital anomalies of the biliary tree, which are more prevalent in female Asian population. Malignant transformation occurs in 10% to 30% of adults with choledochal cysts. A 39-year-old man presented with abdominal pain for 2 months, with irregular thickening of bile duct wall on ultrasound and enhanced CT. Staging with F-FDG PET/CT demonstrated lymph node and liver metastasis. F-FDG PET/CT may become a valuable imaging procedure in diagnosing and staging of carcinoma arising from choledochal cysts...
January 2019: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30369925/extracellular-vesicles-in-hepatobiliary-malignancies
#17
REVIEW
Ainhoa Lapitz, Ander Arbelaiz, Paula Olaizola, Aitziber Aranburu, Luis Bujanda, Maria J Perugorria, Jesus M Banales
Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly arise from the malignant transformation of hepatocytes, cholangiocytes (bile duct epithelial cells) or hepatoblasts (embryonic liver progenitor cells), respectively. Early diagnosis, prognosis prediction and effective therapies are still a utopia for these diseases. Extracellular vesicles (EVs) are small membrane-enclosed spheres secreted by cells and present in biological fluids...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30363713/resection-for-intrahepatic-cholangiocellular-cancer-new-advances
#18
REVIEW
Daniel R Waisberg, Rafael S Pinheiro, Lucas S Nacif, Vinicius Rocha-Santos, Rodrigo B Martino, Rubens M Arantes, Liliana Ducatti, Quirino Lai, Wellington Andraus, Luiz C D'Albuquerque
Intrahepatic cholangiocarcinoma (ICC) is the second most prevalent primary liver neoplasm after hepatocellular carcinoma (HCC), corresponding to 10% to 15% of cases. Pathologies that cause chronic biliary inflammation and bile stasis are known predisposing factors for development of ICC. The incidence and cancer-related mortality of ICC is increasing worldwide. Most patients remain asymptomatic until advance stage, commonly presenting with a liver mass incidentally diagnosed. The only potentially curative treatment available for ICC is surgical resection...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30356299/increased-trimethylation-of-histone-h3k36-associates-with-biliary-differentiation-and-predicts-poor-prognosis-in-resectable-hepatocellular-carcinoma
#19
Huang-Chun Lien, Yung-Ming Jeng, Yu-Ling Jhuang, Ray-Hwang Yuan
INTRODUCTION: Trimethylation of histone H3K36 (H3K36me3), an epigenetic marker of transcription-associated histone modification and stem cell regulation, is expressed in a variety of human cancers. This study elucidated the prognostic significance of H3K36me3 in patients with resectable hepatocellular carcinoma (HCC). METHODS: Expression of H3K36me3 was retrospectively evaluated through immunohistochemistry in 152 surgically resected primary HCCs. RESULTS: In nontumorous liver parenchyma, H3K36Me3 was detected in bile ducts but not in hepatocytes...
2018: PloS One
https://www.readbyqxmd.com/read/30347417/-stage-1-laparoscopy-partial-pve-alpps-followed-by-step-2-hand-assisted-laparoscopic-extended-right-hepatectomy-in-a-patient-with-gallbladder-cancer
#20
Moritz Schmelzle, Robert Öllinger, Bernhard Gebauer, Petr Podrabsky, Johann Pratschke
OBJECTIVE: After recent evaluations of the ALPPS registry, with perioperative results sobering in particular for central bile duct carcinomas, the initial euphoria for this procedure disappeared. It is thus desirable to modify the concept of reducing the invasiveness and high complication rate of the procedure. INDICATIONS: Below we report a 72-year-old female patient with a gallbladder carcinoma locally infiltrating and metastatic to segments 4 b and 5. Due to a too small future liver remnant volume of segments 1 - 3 before planned extended right hemihepatectomy, we planned a laparoscopic partial PVE-ALPPS for hypertrophy induction...
October 22, 2018: Zentralblatt Für Chirurgie
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