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Vishwanatha K Rao, Gerardo Zavala, Abhijit Deb Roy, Richard E Mains, Betty A Eipper
The biosynthetic and endocytic pathways of secretory cells are characterized by progressive luminal acidification, a process which is crucial for posttranslational modifications and membrane trafficking. This progressive fall in luminal pH is mainly achieved by the vacuolar-type-H+ ATPase (V-ATPase). V-ATPases are large, evolutionarily ancient rotary proton pumps that consist of a peripheral V1 complex, which hydrolyzes ATP, and an integral membrane V0 complex, which transports protons from the cytosol into the lumen...
October 14, 2018: Journal of Cellular Physiology
Peilong Dong, Song Gu, Yiqiu Jiang, Wangxiang Yao, Kaibin Zhang, Tianqi Tao, Yang Li, Wang Li, Jianchao Gui
Lateral ankle sprains are one of the most common injuries in sports. Recently, arthroscopic lateral ligament reconstruction has been recently advocated, however no biomechanical studies and clinical application of this technique are available. In this biomechanical study, eighteen fresh-frozen cadaveric ankles were randomized into three groups: (1) intact anterior talofibular ligament (ATFL) and calcaneofibular ligament (CFL), (2) arthroscopic anatomic reconstruction of ATFL and CFL, and (3) all arthroscopic remnant-preserving reconstruction of ATFL and CFL...
October 9, 2018: Biochemical and Biophysical Research Communications
Yusuke Kawamoto, Takahisa Fujikawa, Yusuke Sakamoto, Norio Emoto, Ryo Takahashi, Yuichiro Kawamura, Akira Tanaka
BACKGROUND: The risk of developing hemorrhagic complications during or after emergency cholecystectomy in patients with antithrombic therapy (ATT) remains uncertain. In this study, we evaluate outcomes in patients with ATT undergoing emergency cholecystectomy and assess the relevance between ATT and perioperative complications including bleeding complications. STUDY DESIGN: We retrospectively evaluated 296 patients who were diagnosed as acute cholecystitis and underwent emergency cholecystectomy between 2005 and 2017...
October 12, 2018: Journal of Hepato-biliary-pancreatic Sciences
Aiste Gintaute, Nikolaos Papatriantafyllou, Meshaal Aljehani, Wael Att
PURPOSE: To compare the accuracy of implant impressions using computer-aided impression-making technology and a conventional approach in a standardized setting in vitro, and to verify the effect of implant angulation (40 to 45 degrees) on the accuracy of digital and conventional impression-making procedures. MATERIALS AND METHODS: Four different edentulous mandibular reference models (RMs) were manufactured. Two straight (RM1); four straight (RM2); two straight and two tilted (RM3); and six straight (RM4) dental implants were placed, simulating four different clinical scenarios...
2018: International Journal of Esthetic Dentistry
Sijia Liu, Feichen Shen, Ravikumar Komandur Elayavilli, Yanshan Wang, Majid Rastegar-Mojarad, Vipin Chaudhary, Hongfang Liu
Relation extraction is an important task in the field of natural language processing. In this paper, we describe our approach for the BioCreative VI Task 5: text mining chemical-protein interactions. We investigate multiple deep neural network (DNN) models, including convolutional neural networks, recurrent neural networks (RNNs) and attention-based (ATT-) RNNs (ATT-RNNs) to extract chemical-protein relations. Our experimental results indicate that ATT-RNN models outperform the same models without using attention and the ATT-gated recurrent unit (ATT-GRU) achieves the best performing micro average F1 score of 0...
January 1, 2018: Database: the Journal of Biological Databases and Curation
Mark M Knowles, Adrian Wells
The Attention Training Technique (ATT) was developed with the aim of reducing self-focused attention and increasing executive control as part of metacognitive therapy. So far there is a paucity of data on the neurophysiological effects of ATT. In the present study we tested for specific effects to determine if attention control components of ATT elicit a specific signature that is different from passive listening. Thirty-six healthy volunteers were randomized to an active (follow instructions) or control (ignore instructions) condition...
2018: Frontiers in Psychology
Fatma Ben Abid, Hussam Abdel Rahman S Al Soub
Tuberculous mastitis (TBM) is relatively rare disease with an incidence ranging between 0.1 and 4%. Most of the cases are culture negative and often mistaken with chronic benign idiopathic granulomatous mastitis (IGM). It is very crucial to distinguish culture negative TBM from other causes of mastitis as the treatment differs tremendously. We describe here in a young woman originally from India and residing in Qatar; a non endemic area of tuberculosis; for more then fifteen years. She presented with 2 months history of right breast mass, followed by low grade fever, dry cough, headache, erythema nodosum, arthritis, and arthralgia...
October 6, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Lavina Desai, Ira Shah, Manohar Shaan
Paradoxical reactions (PRs) are exaggerated inflammatory responses owing to recovery of cellular immunity following initiation of anti-tuberculous therapy (ATT). The presentation is worsening of pre-existing symptoms or development of new lesions. A 14-year-old girl with multi-drug-resistant tuberculosis developed a recurrent asymptomatic retropharyngeal abscess while on ATT. She required multiple aspirations of the abscess. Xpert MTB/RIF detected Mycobacterium tuberculosis from the aspirate which was resistant to rifampicin; culture was negative...
October 4, 2018: Paediatrics and International Child Health
Chandravali Madan, Kamal Kishore Chopra, Srinath Satyanarayana, Diya Surie, Vineet Chadha, Kuldeep Singh Sachdeva, Ashwani Khanna, Rajesh Deshmukh, Lopamudra Dutta, Amit Namdeo, Ajay Shukla, Karuna Sagili, Lakhbir Singh Chauhan
BACKGROUND: Tuberculosis (TB) patients with human immunodeficiency virus (HIV) co-infection have worse TB treatment outcomes compared to patients with TB alone. The distribution of unfavourable treatment outcomes differs by socio-demographic and clinical characteristics, allowing for early identification of patients at risk. OBJECTIVE: To develop a statistical model that can provide individual probabilities of unfavourable outcomes based on demographic and clinical characteristics of TB-HIV co-infected patients...
2018: PloS One
Leen Att De Wispelaere, Sabine Ouwehand, Marielle Olsthoorn, Paul Govaert, Liesbeth S Smit, Rogier Cj de Jonge, Maarten H Lequin, Irwin K Reiss, Jeroen Dudink
OBJECTIVE: The aim was to establish any differences in the predictive value of EEG and MRI for outcome in infants treated and not-treated with therapeutic hypothermia (HT) for perinatal asphyxia. We hypothesize that they are equally predictive and that combining both has the highest predictive value. STUDY DESIGN: We retrospectively compared data of infants with hypoxic-ischemic encephalopathy (HIE) who received HT (n = 45) between September 2009 and December 2013 with those of infants with HIE born between January 2004 and August 2009, before HT was available (NT, n = 37)...
September 12, 2018: European Journal of Paediatric Neurology: EJPN
Zhaowei Wu, Limin Zhang, Dandan Qiao, Huping Xue, Xin Zhao
Worldwide occurrence of Methicillin-Resistant Staphylococcus aureus (MRSA) poses enormous challenges for both communities and healthcare settings. Cassette chromosome recombinases (Ccr) specifically exert excision and acquisition of a staphylococcal cassette chromosome mec (SCCmec) in staphylococci and are responsible for the spread of methicillin resistance. This study explored the roles of CcrC2, a recently discovered Ccr, in the horizontal transfer of SCCmec and developed a potential mean to control the spread of methicillin resistance...
October 2, 2018: ACS Synthetic Biology
Martin Bruckbauer, Oliver Prexl, Wolfgang Voelckel, Bernhard Ziegler, Oliver Grottke, Marc Maegele, Herbert Schöchl
OBJECTIVE: To assess the impact of direct oral anticoagulant (DOAC) intake compared to Coumadin (COU) in patients suffering hip fractures (HF). DESIGN: Retrospective cohort analysis SETTING:: Level 1 Trauma Center INTERVENTION:: Timing of surgical hip fixation. PATIENTS: Three-hundred twenty patients ≥ 65 years of age with isolated HF were enrolled into the study: 207 (64.7%) without any antithrombotic therapy (no-ATT), 59 (18.4%) on COU and 54 (16...
September 10, 2018: Journal of Orthopaedic Trauma
Mariko Harada-Shiba, Junya Ako, Hidenori Arai, Atsushi Hirayama, Yoshitaka Murakami, Atsushi Nohara, Asuka Ozaki, Kiyoko Uno, Masato Nakamura
BACKGROUND AND AIMS: Prevalence of familial hypercholesterolemia (FH), a common genetic disorder with a high risk for coronary artery disease (CAD), is high among CAD patients; however, data on FH prevalence among acute coronary syndrome (ACS) patients are limited. EXPLORE-J is the largest registry to diagnose FH among Japanese ACS patients using the 2012 Japan Atherosclerosis Society guidelines. METHODS: This prospective study consecutively recruited patients between April 2015 and August 2016 at 59 sites...
October 2018: Atherosclerosis
David Dejour, Marco Pungitore, Jeremy Valluy, Luca Nover, Mo Saffarini, Guillaume Demey
PURPOSE: The aim of this study was to determine patient and anatomic factors that influence anteroposterior and rotational laxity in knees with ACL tears. Based on the findings of biomechanical studies, we hypothesized that static and dynamic anterior tibial translation (ATT) as well as positive pivot shift would increase with female gender, tibial slope, and meniscal tears. METHODS: The authors prospectively collected preoperative data and intraoperative findings of 417 patients that underwent ACL reconstruction...
September 29, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Mohammad Mahbubur Rahman, Saseendran Pallikadavath
Janani Suraksha Yojana (safe motherhood scheme, or JSY) provides cash incentives to marginal pregnant women in India conditional on having mainly institutional delivery. Using the fourth round of district level household survey (DLHS-4), we have estimated its effects on both intended and unintended outcomes. Our estimates of average treatment effect on the treated (ATT) from propensity score matching are remarkably higher than those found in previous prominent studies using the second and third rounds of the survey (DLHS-2 and DLHS-3)...
September 14, 2018: Economics and Human Biology
David Hajage, Guillaume Chauvet, Lisa Belin, Alexandre Lafourcade, Florence Tubach, Yann De Rycke
Propensity score (PS) methods are widely used in observational studies for evaluating marginal treatment effects. PS-weighting is a popular PS-based method that allows for estimating both the average treatment effect on the overall population (ATE) and the average treatment effect on the treated population (ATT). Previous research has shown that the variance of the treatment effect is accurately estimated only if the variance estimator takes into account the fact that the propensity score is itself estimated from the available data in a first step of the analysis...
September 26, 2018: Biometrical Journal. Biometrische Zeitschrift
Georgios Tsivgoulis, Duncan Wilson, Aristeidis H Katsanos, João Sargento-Freitas, Cláudia Marques-Matos, Elsa Azevedo, Tomohide Adachi, Christian von der Brelie, Yoshifusa Aizawa, Hiroshi Abe, Hirofumi Tomita, Ken Okumura, Joji Hagii, David J Seiffge, Vasileios-Arsenios Lioutas, Christopher Traenka, Panayiotis Varelas, Ghazala Basir, Christos Krogias, Jan C Purrucker, Vijay K Sharma, Timolaos Rizos, Robert Mikulik, Oluwaseun A Sobowale, Kristian Barlinn, Hanne Sallinen, Nitin Goyal, Shin-Joe Yeh, Theodore Karapanayiotides, Teddy Y Wu, Konstantinos Vadikolias, Marc Ferrigno, Georgios Hadjigeorgiou, Rik Houben, Sotirios Giannopoulos, Floris H B M Schreuder, Jason J Chang, Luke A Perry, Maximilian Mehdorn, João-Pedro Marto, João Pinho, Jun Tanaka, Marion Boulanger, Rustam Al-Shahi Salman, Hans R Jäger, Clare Shakeshaft, Yusuke Yakushiji, Philip M C Choi, Julie Staals, Charlotte Cordonnier, Jiann-Shing Jeng, Roland Veltkamp, Dar Dowlatshahi, Stefan T Engelter, Adrian R Parry-Jones, Atte Meretoja, Panayiotis Mitsias, Andrei V Alexandrov, Gareth Ambler, David J Werring
OBJECTIVE: Whether intracerebral haemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin-K antagonists (VKA-ICH) is uncertain. METHODS: We performed a systematic review and individual patient data meta-analysis of cohort studies comparing clinical and radiological outcomes between NOAC-ICH and VKA-ICH patients. The primary outcome measure was 30-day all-cause mortality...
September 26, 2018: Annals of Neurology
Kevin Staats, Torben Wannmacher, Valerie Weihs, Ulrich Koller, Bernd Kubista, Reinhard Windhager
PURPOSE: To prevent early failure it is necessary to evaluate modern TKA system for possible shortcomings during implantation. The aim of this study was to evaluate the radiographic outcome and short-term survival of a modern cemented primary TKA system compared to its predecessor. METHODS: The authors reviewed 529 primary cemented TKAs [276 Attune (ATT) and 253 PFC Sigma (PFC)], which were implanted between 2014 and 2017 concerning the radiographic outcome and short-term survival...
September 22, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Lindsay J May, Angela Lorts, Christina VanderPluym, Jennifer Conway, M Patricia Massicotte, Morgan M Millar, Marie E Steiner, David N Rosenthal
Management of antithrombotic therapy (ATT) for pediatric ventricular assist devices is challenging, and the Berlin EXCOR remains the only FDA-approved option. Among those on the EXCOR, 28% have neurologic complications and major bleeding occurs in 50%. The Edmonton Protocol was developed to guide ATT, but the adverse event rate remains high, leading most centers to make modifications. The objective of this study is to characterize antithrombotic practice variation among North American pediatric ventricular assist device programs, in order to guide future research...
September 12, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Manuel Taso, Arnaud Guidon, Li Zhao, Koenraad J Mortele, David C Alsop
PURPOSE: To demonstrate the feasibility of noninvasively measuring pancreatic perfusion using pseudocontinuous arterial spin labeling (ASL) and to derive quantitative blood-flow and transit-time measurements in healthy volunteers. METHODS: A pseudocontinuous ASL sequence with background suppression and a single-slice single-shot fast-spin-echo readout was acquired at 3 T in 10 subjects with a single standard postlabeling delay (PLD) of 1.5 s and in 4 additional subjects with 4 PLD from 0...
September 5, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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