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X Q Ji, C H Zhu, H Y Song
Objective: To understand the healthy status of radiation workers on the staff in Nanjing, and to analysis the relationship between abnormal crystalline lens and its influencing factors. Methods: We described physical indicators including blood pressure (BP) 、blood sugar (BG) 、thyroid B ultrasound、crystalline lens、chromosome and so on among 3 349 radiation workers on the staff in the year 2016 from Jan 1 to Dec 31, and the abnormal results of crystalline lens were analyzed statistically. Results: The rate of abnormal BP、BG、WBC、Thyroid B ultrasound、crystalline lens was 19...
August 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
C Liang, W Wei
Objective: To provide scientific evidence for Prevention and control measures of Occupational Forest Encephalitis (OFE) by analyzing the Epidemiological and occupational characteristics, clinical manifestation of OFE cases reported in HunlunBuir city during 2008~2017. Methods: Based on the China Center for Disease Control and Prevention Information System, a database of OFE cases in HunlunBuir from 2008~2017 was established. The Epidemiological characteristics of OFE were analyzed including three distributions, the available information includes 291 cases of population, geographical, periods, occupational distribution, clinical manifestations and laboratory examinations...
August 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
Y Luo, G J Bao, R M Chen, C Mao, B F Jia, Y Q Yu, G F Yu
Objective: To explore the turnover intention of nurses in Quzhou and its influential factors. Methods: From July to August in 2017 cross-sectional study and self-filled questionnaire are used to investigate 980 nurses from 7 hospitals in Quzhou, including two third-level hospitals and five second-level ones. T-test, F-test, Pearson and linear regression are used in data with the method of statistical analysis. Results: The total score of turnover intention of nurses was (14.95±3.17) points, and the index value was 62...
August 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
S L Wu, X Qin, S C Guo
Objective: To elucidate the effect of taurine on neurotoxicity induced by Mn by investigating cell cycle and apoptosis in manganese exposed rats. Methods: 156 healthy male SD rats were randomly divided into 1 control group, 3 manganese exposure groups (10, 15, and 20 mg/kg respectively) , and 9 intervened groups based on orthogonal design, with 12 rats in each group. After 12 weeks of exposure, all rats were decapitated and striatums were removed, cell cycle was analyzed by flow cytometry, the apoptosis was detected by TUNEL, level of Mn was determined...
August 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
M H Liu, F Zhou, X B Wang, L P Chen, G Z Li, Q Zhao
Objective: To investigate the incidence rate of transjugular intrahepatic portosystemic shunt (TIPS) complications in the treatment of cirrhotic portal hypertension, and analyze the cause of complication to management methods. Methods: Data of 116 patients obtained from Zhongnan Hospital of Wuhan University were retrospectively analyzed. Portal venous pressure, routine blood test, coagulation test, liver and kidney function test, ammonia blood test, imaging and endoscopy reports were collected before and after procedure...
August 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
B F Zhang, M L Cheng, Y P Wang, Q Zhang, L Yu, X K Zhao, M Mu, Y Liu
Objective: To observe the effects of blueberry and nuclear expression of transcription factor-кb (NF-кb) p65 in an experimental rat model of liver fibrosis. Methods: Forty-five Sprague-Dawley rats were randomly divided into isotonic saline control group (A); model group (B); blueberry juice prevention group (C, 15 g/kg); dan-shao-hua-xian capsule prevention group (D, 1 g/kg); and blueberry juice + dan-shao-hua-xian capsule prevention group (E). Rat liver fibrosis model was established by covalent compound carbon tetrachloride (CCl(4))...
August 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
C Zhou, H Wu, Y Liu, C Yin, B Yang
Objective: To investigate the effects of long non-coding RNA HULC on downstream related targets regulating the migration and invasion of hepatoma cells and theirs mechanism of action. Methods: The expression of highly upregulated in liver cancer (HULC) in hepatocellular carcinoma, and adjacent normal liver tissues and different hepatocellular carcinoma cells were detected by qPCR. The correlation between clinicopathological data of HULC and liver cancer patients were analyzed. Dual-luciferase reporter gene detected the interaction between HULC and miR-186...
July 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Y Ren, Y Z Kan, L F Kong
Objective: To explicit, the expression of chemokine receptor 3 in HCC tissues and its relationship with overall survival of patients, and to explore the effect of targeted silencing CXCR3 gene on proliferation of hepatocellular carcinoma cells and its mechanism of action. Methods: The expression of CXCR3 in 60 cases of hepatocellular carcinoma and its adjacent tissues were detected by immunohistochemistry. The clinicopathological correlations between the expression levels of CXCR3 in hepatoma tissues of liver cancer patients were analyzed and univariate Kaplan-Meier survival analysis was performed in combination with follow-up data...
July 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
A Liu, W Xu, H Xu, Y Wang, H L Zhao, J C Sha, Y M Gu
Objective: To explore the clinical value of 3D-DSA technology in the diagnosis and treatment guidance of hepatic artery chemoembolization. Methods: Liver cancer patients in the treatment groups were collected to receive 3D-DSA imaging guidance at the Affiliated Hospital of Xuzhou Medical University between March and May 2017. In addition, routine 2D-DSA imaging was selected for treatment-received group. Intra-operative blood vessels and tumor-like lesions were observed. The total exposure dose (CAK, unit mGy), cumulative irradiation intensity per unit area (DAP, unit mGy...
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Y L Li, Q F Zhang, W W Yin, D Z Zhang
Objective: To explore the relationship between sialic-acid-binding immunoglobulin-like lectin 7 (Siglec-7) expressed on NK cells and hepatitis B virus-related cirrhosis. Methods: Peripheral venous blood samples were collected from 23 healthy controls and 31 patients with hepatitis B virus-related cirrhosis (Child-Pugh A, n = 7; Child-Pugh B, n = 12; Child-Pugh C, n = 12). Peripheral blood mononuclear cells (PBMCs) were obtained by using Ficoll-Hypaque density gradient centrifugation and the expression of Siglec-7 and NK cells phenotype and their subpopulations were detected by flow cytometry...
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
M Ren, Y Y Kong, X X Shen, X Cai, J C Kong
Objective: To study the clinicopathologic features, differential diagnosis and prognosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM). Methods: Histopathologic evaluation and immunohistochemical study by HRP multimer method were carried out in 24 cases of LM and LMM from 2012 to 2017 at Fudan University Shanghai Cancer Center. The clinical information and follow-up data were analyzed. Results: Of total 24 cases, there were 7 cases of LM and 17 cases of LMM; 10 males and 14 females. The age of patients ranged from 32 to 88 years (mean 67 years)...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Ricardo G Pastorello, Camila Destefani, Pedro H Pinto, Caroline H Credidio, Rafael X Reis, Thiago de A Rodrigues, Maryane C de Toledo, Louise De Brot, Felipe de A Costa, Antonio G do Nascimento, Clóvis A L Pinto, Mauro A Saieg
BACKGROUND: The impact of rapid on-site evaluation (ROSE) on thyroid aspirates has been a matter of extensive debate. In the current study, the authors reviewed all thyroid fine-needle aspiration biopsies (FNABs) performed in their service in recent years to evaluate the impact of ROSE on final adequacy and diagnostic rates. METHODS: All ultrasound-guided FNABs of the thyroid performed between July 2015 and July 2017 were included retrospectively. ROSE was performed by experienced cytopathologists, with production of Romanowsky-stained slides for immediate evaluation...
October 14, 2018: Cancer Cytopathology
Raymond C Rosen, Claus G Roehrborn, Michael J Manyak, Juan Manuel Palacios-Moreno, Timothy H Wilson, Zrinka Lulic, Francois Giuliano
AIMS: Five-α reductase inhibitor (5ARI) therapy has been associated with sexual dysfunction in some patients. This study assessed the impact of a fixed-dose combination of the 5ARI dutasteride 0.5 mg and the α1 -adrenoceptor antagonist tamsulosin 0.4 mg (DUT-TAM FDC) on Men's Sexual Health Questionnaire (MSHQ) domain scores in patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH). METHODS: This was a post hoc analysis of a double-blind, randomized, placebo-controlled, parallel-group, multicenter study in sexually active patients, aged ≥50 years, with a confirmed clinical diagnosis of BPH...
October 13, 2018: International Journal of Clinical Practice
A Nast, M Gaskins, L Eisert, R N Werner, L Borradori, B Marinovic, C Paul, C Dressler
BACKGROUND: Most clinical guidelines in dermatology are encyclopaedic, covering a disease and its aetiology, diagnosis, treatment and prevention in their entirety. The usability and uptake of guideline recommendations might be improved by guidelines that are more concise and address specific questions ranked by users according to their perceived importance. OBJECTIVE: To survey the largest association of dermatologists in Europe, identify which questions in their everyday practice they felt would benefit from short, evidence-based guidance, and rank these systematically...
October 13, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Sanaz Naghizadeh, Behzad Mansoori, Ali Mohammadi, Hossein Samadi Kafil, Zohreh Mousavi, Ebrahim Sakhinia, Behzad Baradaran
BACKGROUND: Although there are multiple treatments for lung cancer, the death rate of this cancer remains high because of metastasis in earlier stages. So a novel treatment for overcoming metastasis is urgently needed. Overexpression of high-mobility group AT-hook 2 (HMGA2), a nonhistone chromosomal protein has been observed in metastatic cancers. So, we suggested that HMGA2 upregulation may play a critical role in treating lung cancer. METHODS: The A549 cells were transfected with specific HMGA2 small interfering RNA (siRNA) using transfection reagent...
October 14, 2018: Journal of Cellular Biochemistry
Aaron M Secrest, Dena M Elkeeb, Bryn Petron, Ashley Elsensohn, LaVar D Edwards, Gerald G Krueger, Kristina C Duffin
Treatment of psoriasis with systemic corticosteroids is controversial. Concerns arise from cases of generalized pustular psoriasis flares, erythroderma or worsening psoriasis upon tapering or discontinuing systemic corticosteroids.1,2 Despite the lack of relevant treatment guidelines, recent studies report that systemic corticosteroids are prescribed commonly for psoriasis.3,4 Estimates from the U.S. This article is protected by copyright. All rights reserved.
October 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
C Bombonato, R Pampena, C Franceschini, S Piana, F Perino, A Di Stefani, M Ardigò, M C Fargnoli, P Frascione, S Borsari, G Pellacani, K Peris, C Longo
BACKGROUND: Sclerosing nevus with pseudomelanomatous features (SNPF) is a clinical and pathologic entity that mimics melanoma both clinically and histologically. The lesion is a melanocytic nevus, histologically characterized by fibrosis and a pseudo-melanomatous proliferation. It is typically seen in young to middle-aged individuals, mainly on the back, where microtrauma or inflammatory changes are more frequent. Dermoscopic description of SNPF has been reported so far in one case series...
October 13, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Nian-Kang Sun, Abhidha Kohli, Shang-Lang Huang, Ting-Chang Chang, Chuck C-K Chao
We report here that the androgen receptor (AR) and ABCB1 are upregulated in a model of acquired taxol resistance (txr) in ovarian carcinoma cells. AR silencing sensitizes txr cells to taxol threefold, whereas ectopic AR expression in AR-null HEK293 cells induces resistance to taxol by 1.7-fold. AR activation using the agonist dihydrotestosterone (DHT) or sublethal taxol treatment upregulates ABCB1 expression in both txr cells and AR-expressing HEK293 cells. In contrast, AR inactivation using the antagonist bicalutamide downregulates ABCB1 expression and enhances cytotoxicity to taxol...
October 14, 2018: Journal of Cellular Physiology
Ching-Han Yu, Shu-Chen Chu, Shun-Fa Yang, Yih-Shou Hsieh, Chih-Yi Lee, Pei-Ni Chen
Cinnamomum cassia has been widely studied in different fields to reveal its antidiabetic, antidepressive, antiviral, anti-inflammatory, antiosteoporotic, and anticancer effects. Its antimalignant activities have been explored in lung cancer, breast cancer, colorectal cancer, and even oral cancer, but the detailed signaling mechanism and effects of this plant on animal models need to be clarified. In the current study, C. cassia extract (CCE) was used to investigate the antitumorigenesis mechanism in vitro and in vivo...
October 14, 2018: Journal of Cellular Physiology
Jaesung Seo, Garam Guk, Seung-Ho Park, Mi-Hyeon Jeong, Ji-Hoon Jeong, Ho-Geun Yoon, Kyung-Chul Choi
The role of histone deacetylase 3 (HDAC3) is to repress the expression of various genes by eliminating acetyl group from histone. Thus, the regulation of HDAC3 activity is essential to maintain cellular homeostasis. In this study, we found that HDAC3 interacts with c-Src kinase. However, the interaction between HDAC3 and c-Src was previously reported, it has still been ambiguous whether c-Src phosphorylates HDAC3 and affects the function of HDAC3. First, we confirmed that HDAC3 directly binds to c-Src, and c-Src identified to interact with C-terminal domain (277-428 a...
October 14, 2018: Journal of Cellular Physiology
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