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Hai Li, Bo Hu, Zhe Guo, Xueqing Jiang, Xinyu Su, Xiaoyi Zhang
PURPOSE: The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C to T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer (BC) patients undergoing epirubicin/cyclophosphamide-docetaxel (EC-D) adjuvant chemotherapy. MATERIALS AND METHODS: 427 BC patients who had underwent surgery were consecutively enrolled in this prospective cohort study. All patients were scheduled to receive EC-D adjuvant chemotherapy regimen, and they were divided into UGT2B7 -161 CC (n=141), UGT2B7 -161 CT (n=196), and UGT2B7 -161 TT (n=90) groups according to their genotypes...
January 2019: Yonsei Medical Journal
E M Dogan-Guner, H Mohamed, N Orbey, N Goodyear
AIMS: Hydrogen peroxide (H2 O2 ) disinfection applications are limited by its rapid inactivation. The aims of this study were to 1) microencapsulate H2 O2 in silica hydrogels to obtain controlled release up to 72 hours, 2) test hydrogel antimicrobial activity against four common pathogens, and 3) assess H2 O2 release kinetics and antimicrobial activity in 35 - 65% relative humidity and 37°C to approximate bandaged wound conditions. METHODS AND RESULTS: Hydrogels were characterized using scanning electron microscopy, nitrogen sorption porosimetry, Brunauer Emmet Teller analysis, and the Barret - Joyner - Halenda method...
December 16, 2018: Journal of Applied Microbiology
Ki-Dong Sung, Elizabeth J Pekas, Steven D Scott, Won-Mok Son, Song-Young Park
INTRODUCTION: Childhood obesity is strongly associated with cardiovascular disease (CVD) development. It is necessary to combat unfavorable outcomes of obesity at a young age by utilizing effective interventions, such as exercise. PURPOSE: We sought to examine the effects of a jump rope exercise program on CVD risk factors, including body composition, vasoactive substances, inflammation, and vascular function in prehypertensive adolescent girls. METHODS: Forty girls (age 14-16) were recruited and randomly assigned to a jump rope exercise group (EX, n = 20) or control group (CON, n = 20)...
December 15, 2018: European Journal of Applied Physiology
Bruno Senghor, Hubert Bassène, Saber Khelaifia, Catherine Robert, Pierre-Edouard Fournier, Raymond Ruimy, Cheikh Sokhna, Didier Raoult, Jean-Christophe Lagier
Oceanobacillus timonensis Marseille-P3532T (CSUR P3532, CCUG 70981) and Oceanobacillus senegalensis Marseille-P3587T (CSUR P3587, CCUG 70613), are the type strains of O. timonensis sp. nov. and O. senegalensis sp. nov., respectively. They are moderately halophilic, aerobic, motile and Gram-stain positive bacteria. The strains P3532T and P3587T were isolated from stools with 3.8% and 2.1% sodium chloride (NaCl) of healthy 10 year old female and male 7-year-old children, respectively and living respectively at Dielmo and N'diop two villages in Senegal (West Africa)...
December 15, 2018: Antonie Van Leeuwenhoek
Lyuba Miteva, Anastasiya Trenova, Georgi Slavov, Spaska Stanilova
IL-12-family cytokines play a pivotal role in neuroinflammation and neurodegeneration in relapsing-remitting multiple sclerosis (RRMS). The aim of the study was to evaluate whether two polymorphisms in IL12B gene, rs17860508 and rs3212227, are associated with RRMS, and to define their function effect on serum level of IL-12p40 and IL-23 and degree of disability in RRMS cases. In total 156 Bulgarian patients with Expanded Disability Status Scale score ranging from 1.0 to 3.5 in remission of the disease and 379 controls were genotyped by polymerase chain reaction-based methods...
December 15, 2018: Acta Neurologica Belgica
F F Laranjeira, T T C Santos, A S Moreira, I Sanches, A S Nascimento, S X B Silva, E C Andrade, D O Almeida
Diaphorina citri Kuwayama (Hemiptera: Liviidae), named as Asian citrus psyllid (ACP), is the vector of the bacterium associated with huanglongbing (HLB), the most destructive citrus disease. The use of citrus flushing and ACP monitoring tools is essential for the knowledge of the occurrence pattern of cycles of both and for the improvement of the ACP management. During 3 years, 20 branches from 20 trees were evaluated for vegetative flushing, ACP abundance, and occupation in tree and branches in a Brazilian citrus area free for HLB...
December 15, 2018: Neotropical Entomology
Bang-Liang Deng, Shu-Li Wang, Xin-Tong Xu, Hua Wang, Dong-Nan Hu, Xiao-Min Guo, Qing-Hua Shi, Evan Siemann, Ling Zhang
Greenhouse gas emissions from agricultural soils contribute substantially to global atmospheric composition. Nitrous oxide (N2 O) is one important greenhouse gas induces global warming. Nitrification inhibitors (NI) or biochar can be effective soil N2 O emission mitigation strategies for agricultural soils. However, due to differences in crop physiological traits or agricultural management, the effectiveness of mitigation strategies varies among agricultural systems. Camellia oleifera is a woody oil plant widely grown and requires intensive N input, which will potentially increase N2 O emissions...
December 15, 2018: Environmental Science and Pollution Research International
Alan W Stacy, Liesl A Nydegger, Yusuke Shono
Many people enrolled in drug diversion programs are not receiving evidence-based prevention for HIV or hepatitis. This study translated basic research from cognitive science to increase screening for infection and condom use in this population. A parallel three-condition randomized trial was conducted in a drug diversion sample (N = 358), comparing a memory practice condition with two active control conditions. Outcomes were condom use frequency and testing for infection (hepatitis B/C, HIV). At 3-month follow-up, participants in the memory practice condition were at least twice as likely (OR = 2...
December 15, 2018: Journal of Behavioral Medicine
S V Flórez-Muñoz, J F Alzate, A C Mesa-Arango
BACKGROUND: Sporotrichosis is a subcutaneous mycosis that affects humans and other animals. Infection prevails in tropical and subtropical countries. Until a few years ago, it was considered that two varieties of Sporothrix schenckii caused this mycosis, but by applying molecular taxonomic markers, it has been demonstrated that there are several cryptic species within S. schenckii complex which varies in susceptibility, virulence, and geographic distribution. OBJECTIVE: This study aimed to identify the clinical isolates of Sporothrix spp...
December 15, 2018: Mycopathologia
C Couffignal, J Bertrand, S Sportiche, Marine Jarroir, S El Balkhi, N Djebrani-Oussedik, J Poupon, X Declèves, F Mentré, F Bellivier
PURPOSE: Lithium (Li), the first-line treatment of bipolar disorder, was first developed as an immediate-release form with a routine therapeutic drug monitoring 12 h after the last dose. In Europe, the most commonly prescribed form is a sustained release (srLi). Yet no pharmacokinetics (PK) study has been published of srLi, administered once a day, in adults. The present study describes srLi PK in the serum and erythrocytes of bipolar patients. METHODS: To assess srLi PK, we studied prospectively 17 French bipolar patients on a median dose of 1000 mg (600-1600) for at least 2 years...
December 15, 2018: European Journal of Clinical Pharmacology
S Yang, W D Leslie, S N Morin, L M Lix
Fracture risk scores generated from population-based administrative healthcare data showed comparable or better discrimination than the Fracture Risk Assessment Tool (FRAX) scores computed without bone mineral density for predicting incident major osteoporotic fracture. Administrative data may be useful to identify individuals at high fracture risk at the population level. PURPOSE: To evaluate the discrimination of fracture risk scores defined using inputs available from administrative data for predicting incident major osteoporotic fracture (MOF) and hip fracture (HF) alone...
December 15, 2018: Osteoporosis International
G Elia
Monokine induced by interferon (IFN)-γ (MIG) / chemokine (C-X-C motif) ligand 9 (CXCL)9 is involved in the pathogenesis of psoriatic arthritis (PsA). It was demonstrated that both blood plasma-derived dendritic cells (pDCs) and pDCs isolated from rheumatoid arthritis (RA) and PsA synovial fluid (SF), expressed CXC receptor (R) 3 and CXCR4, and that the chemotaxis of blood-derived pDCs is stimulated by MIG, (IFN)-γ-inducible protein 10 (IP-10)/CXCL10, IFN-inducible T-cell α chemoattractant (I-TAC) )/CXCL11 and stromal cell-derived factor 1 (SDF-1)/ CXCL12, present in RA and PsA SF...
November 2018: La Clinica Terapeutica
E Alagna, O E Santangelo, D D Raia, V Gianfredi, S Provenzano, A Firenze
INTRODUCTION: In Italy, as in the rest of the world, the number of homeless people is increasing considerably. Many of them suffer from chronic conditions, mental health problems and addiction to alcohol, drugs or smoking, and need complex medical care. Their health status is often exacerbated by greater difficulty in accessing primary care. The aim of the present study was to assess health conditions of homeless people living in Palermo, Southern Italy, and to find ways to limit the spread of common infectious diseases that can be prevented by vaccination...
January 2019: Annali di Igiene: Medicina Preventiva e di Comunità
Xiyan Li, Xin Wang, Michael P Snyder
Metformin elicits pleiotropic effects that are beneficial for treating diabetes, and as well as particular cancers and aging. In spite of its importance, a convincing and unifying mechanism to explain how metformin operates is lacking. Here we describe investigations into the mechanism of metformin action through heme and hemoprotein(s). Metformin suppresses heme production by 50% in yeast, and this suppression requires mitochondria function, which is necessary for heme synthesis. At high concentrations comparable to those in the clinic, metformin also suppresses heme production in human erythrocytes, erythropoietic cells and hepatocytes by 30-50%; the heme-targeting drug artemisinin operates at a greater potency...
December 15, 2018: G3: Genes—Genomes—Genetics
Yannie Soo, Jill M Abrigo, Kam Tat Leung, Suk Fung Tsang, Hing Lung Ip, Sze Ho Ma, Karen Ma, Wing Chi Fong, Siu Hung Li, Richard Li, Ping Wing Ng, Kwok Kui Wong, Wenyan Liu, Bonnie Y K Lam, Ka Sing Lawrence Wong, Vincent Mok, Winnie Chiu Wing Chu, Thomas W Leung
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMBs), which predict future intracerebral haemorrhage (ICH), may guide anticoagulant decisions for atrial fibrillation (AF). We aimed to evaluate the risk of warfarin-associated ICH in Chinese patients with AF with CMBs. METHODS: In this prospective, observational, multicentre study, we recruited Chinese patients with AF who were on or intended to start anticoagulation with warfarin from six hospitals in Hong Kong. CMBs were evaluated with 3T MRI brain at baseline...
December 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Zhuangzhuang Li, Ran Wen, Yiqing Du, Shaozhe Zhao, Pan Zhao, Haiqiang Jiang, Rong Rong, Qingtao Lv
A simple, sensitive and selective high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed and validated for simultaneous determination and pharmacokinetic study of 15 active compounds (Saikosaponin A, Baicalin, Wogonin, Glycyrrhizic acid, Glycyrrhetinic acid, Albiflorin, Paeoniflorin, Liquiritin, Isoliquiritin, Liquiritigenin, Isoliquiritigenin, Cinnamic acid, Gallic acid, Wogonoside and Oroxylin A) in rat plasma. After a feasible protein precipitation using methanol for sample preparation, chromatographic separation was carried out with a Halo® C18 column (2...
December 8, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Mitsukuni Suenaga, Sebastian Stintzing, Shu Cao, Wu Zhang, Dongyun Yang, Yan Ning, Satoshi Okazaki, Martin D Berger, Yuji Miyamoto, Marta Schirripa, Shivani Soni, Afsaneh Barzi, Volker Heinemann, Heinz-Josef Lenz
BACKGROUND: Epidermal growth factor receptor signalling blockade increases CCL5 expression that regulates either the anti-tumour immune response or tumour progression. We investigated the potential role of CCL5/CCR5 axis in cetuximab-based treatment in metastatic colorectal cancer (mCRC) patients. PATIENTS AND METHODS: Genomic DNA was extracted from 491 samples of two different cohorts with KRAS wild-type mCRC from the FIRE-3 trial: an evaluation cohort of 244 patients receiving cetuximab plus FOLFIRI and a control cohort of 247 patients receiving bevacizumab plus FOLFIRI...
December 13, 2018: European Journal of Cancer
Indu Kumari, Navjot Kaur, Shuchi Gupta, Neetu Goel
Binding of four DNA nucleotide units with (ZnO)3 cluster in an aqueous phase has been investigated using density functional theory (DFT) and time dependent-density functional theory (TDDFT) method and the stability order for (ZnO)3 -nucleobases/sugar/phosphate systems is predicted as phosphate > C > A > S > T ∼ G. The order of binding energy for (ZnO)3 -nucleotide hybrid systems is observed to be (ZnO)3  + nuc-C ˃ (ZnO)3  + nuc-A ˃ (ZnO)3  + nuc-G ˃ (ZnO)3  + nuc-T...
December 7, 2018: Journal of Molecular Graphics & Modelling
Saraschandra Vallabhajosyula, Jeffrey B Geske, Mukesh Kumar, Rahul Kashyap, Kianoush Kashani, Jacob C Jentzer
BACKGROUND: The association of pulmonary hypertension (PH) in patients with sepsis is lesser understood. METHODS: This was a retrospective study of adult patients admitted to the intensive care unit during 2007-2014 for sepsis and septic shock, with echocardiography performed <72 h. PH was defined as tricuspid regurgitation peak velocity (TRV) > 3 m/s on Doppler echocardiography. Patients with prior PH, pulmonary stenosis, or without measurable TRV were excluded...
December 8, 2018: Journal of Critical Care
Brian A Bernet, Erin T Peskura, Samuel T Meyer, Patrick C Bauch, Megan B Donaldson
PURPOSE: To investigate the effects of physical therapy interventions of the hip on outcomes of pain and disability in patients with low back pain. DATA SOURCES: PubMed, CINAHL, Scopus, Web of Science, and SPORTDiscus were searched from inception to 18 April 2018. STUDY SELECTION/ELIGIBILITY CRITERIA: The following inclusion criteria were required to be met: (1) randomized controlled trials; (2) populations with diagnosed low back pain; and (3) interventions that target the hip joint...
December 1, 2018: Musculoskeletal Science & Practice
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