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Type 3 C Diabetes

J W Varni, A M Delamater, K K Hood, J K Raymond, N T Chang, K A Driscoll, J C Wong, J P Yi-Frazier, E K Grishman, M A Faith, S D Corathers, J C Kichler, J L Miller, E M Doskey, V P Aguirre, R W Heffer, D P Wilson
AIM: To test the measurement properties of the revised and updated Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module originally developed in Type 1 diabetes in youth with Type 2 diabetes. METHODS: The PedsQL 3.2 Diabetes Module and PedsQL Generic Core Scales were administered in a field test study to 100 young people aged 9-25 years with Type 2 diabetes. Factor analysis was conducted to determine the factor structure of the items. RESULTS: The 15-item Diabetes Symptoms Summary Score and 12-item Type 2-specific Diabetes Management Summary Score were empirically derived through factor analysis...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
I C Chetter, A V Oswald, E McGinnis, N Stubbs, C Arundel, H Buckley, K Bell, J C Dumville, N A Cullum, M O Soares, P Saramago
BACKGROUND: Surgical wounds healing by secondary intention can be difficult and costly to manage and are profoundly under researched. This prospective inception, cohort study aimed to derive a better understanding of surgical wounds healing by secondary intention and to facilitate the design of future research investigating effective treatments. OBJECTIVES: To investigate the clinical characteristics of patients with surgical wounds healing by secondary intention and the surgeries that preceded their wounds; to clearly delineate the clinical outcomes of these patients, specifically focusing on time to wound healing and its determinants; to explore the types of treatments for surgical wounds healing by secondary intention; and to assess the impact surgical wounds healing by secondary intention have on patients' quality of life...
September 18, 2018: International Journal of Nursing Studies
Tsai-Chung Li, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Cheng-Chieh Lin
This study aims to develop a risk score system for hepatocellular carcinoma (HCC) in patients with type 2 diabetes using the Taiwan National Diabetes Care Management Program database. This retrospective cohort study included 31,723 Chinese patients who had type 2 diabetes, aged 30-84 years. Participants were randomly grouped into derivation and validation sets in 2:1 ratio. Cox proportional hazard regression models were used to identify the risk factors of HCC in the derivation set. Discrimination ability of the model was assessed by means of a receiver operating characteristic curve and performance was expressed as the c statistic, assessed internally on validation data sets...
October 17, 2018: Seminars in Oncology
Aruna D Pradhan, Nina P Paynter, Brendan M Everett, Robert J Glynn, Pierre Amarenco, Marshall Elam, Henry Ginsberg, William R Hiatt, Shun Ishibashi, Wolfgang Koenig, Børge G Nordestgaard, Jean-Charles Fruchart, Peter Libby, Paul M Ridker
Observational, genetic, and experimental data indicate that triglyceride rich lipoproteins (TRLs) likely participate causally in atherothrombosis. Yet, robust clinical trial evidence that triglyceride (TG) lowering therapy reduces cardiovascular events remains elusive. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARM-α), pemafibrate, will be used to target residual cardiovascular risk remaining after treatment to reduce low-density lipoprotein cholesterol (LDL-C) in individuals with the dyslipidemia of type 2 diabetes mellitus (T2)...
September 29, 2018: American Heart Journal
Deepak Bhosle, Vandana Bhosle, Jyoti Bobde, Huzaif Shaikh, Rajesh Kadam
Objectives: Patients with prediabetes are not only at increased risk of progression to type 2 diabetes, but they are also at high risk of developing cardiovascular risk compared to normoglycemic people. Further, prediabetes is also often associated with abnormal lipid levels (dyslipidemia). We therefore aimed to evaluate the effect of Saroglitazar in patients with prediabetes and dyslipidemia. Methods: This was a prospective, single centre, single arm study involving patients with pre-diabetes and dyslipidemia...
March 2018: Journal of the Association of Physicians of India
Junkui Wang, Zhiguo Tang, Yong Zhang, Chuan Qiu, Ling Zhu, Na Zhao, Zhongwei Liu
Featured by heart dysfunction, the diabetic cardiomyopathy is causing mortality and morbidity in type 2 diabetes mellitus patients. Matrine was considered as a cardioprotective agent. This study was aimed to investigate the therapeutic effects and molecular mechanisms of matrine on advanced glycation end products (AGEs)- induced cardiac dysfunctions. Rats and isolated primary myocytes were exposed to AGEs. Left ventricular hemodynamic parameters were used to assess the cardiac function. Cell apoptosis was detected with TUNEL assay...
October 16, 2018: European Journal of Pharmacology
C W le Roux, B Chubb, E Nørtoft, A Borglykke
Background/Objectives: The economic burden of obesity and type 2 diabetes (T2D) rises with increasing prevalence. This study estimates the association between obesity, healthcare resource utilization (HCRU) and associated costs in individuals with/without T2D. Subjects/Methods: This observational cohort study used the United Kingdom Clinical Practice Research Datalink data. Between 1 January 2011 and 31 December 2015, total HCRU costs and individual component costs (hospitalizations, general practitioner contacts, prescriptions) were calculated for individuals linked to the Hospital Episodes Statistics database with/without T2D with normal weight, overweight, class I, II, III obesity...
October 2018: Obesity Science & Practice
Pedrum Mohammadi-Shemirani, Jennifer Sjaarda, Hertzel C Gerstein, Darin J Treleaven, Michael Walsh, Johannes F Mann, Matthew J McQueen, Sibylle Hess, Guillaume Paré
BACKGROUND: Identifying markers of chronic kidney disease (CKD) that occur early in the disease process and are specific to loss of kidney function rather than other underlying causes of disease may allow earlier, more accurate identification of patients who will develop CKD. We therefore sought to identify diagnostic blood markers of early CKD that are caused by loss of kidney function by using an innovative "reverse Mendelian randomization" (MR) approach. METHODS: We applied this technique to genetic and biomarker data from 4147 participants in the Outcome Reduction with Initial Glargine Intervention (ORIGIN) trial, all with known type 2 diabetes, impaired fasting glucose, or impaired glucose tolerance...
October 18, 2018: Clinical Chemistry
Eduardo Sánchez-Lara, Samuel Treviño, Brenda L Sánchez-Gaytán, Enrique Sánchez-Mora, María Eugenia Castro, Francisco J Meléndez-Bustamante, Miguel A Méndez-Rojas, Enrique González-Vergara
Cytosine, a DNA and RNA building-block, and Metformin, the most widely prescribed drug for the treatment of Type 2 Diabetes mellitus were made to react separately with ammonium or sodium metavanadates in acidic aqueous solutions to obtain two polyoxovanadate salts with a 6:1 ratio of cation-anion. Thus, compounds [HCyt]6 [V10 O28 ]·4H2 O, 1 and [HMetf]6 [V10 O28 ]·6H2 O, 2 (where HCyt = Cytosinium cation, [C4 H6 N3 O]+ and HMetf = Metforminium cation, [C4 H12 N5 ]+ ) were obtained and characterized by elemental analysis, single crystal X-ray diffraction, vibrational spectroscopy (IR and Raman), solution 51 V-NMR, thermogravimetric analysis (TGA-DTGA), as well as, theoretical methods...
2018: Frontiers in Chemistry
Sandro Gentile, Felice Strollo, Francesca Viazzi, Giuseppina Russo, Pamela Piscitelli, Antonio Ceriello, Carlo Giorda, Piero Guida, Paola Fioretto, Roberto Pontremoli, Salvatore De Cosmo, The Amd-Annals Study Group
We performed a real-life analysis of clinical and laboratory parameters, in orally treated T2DM patients aiming at identifying predictors of insulin treatment initiation. Overall, 366955 patients (55.8% males, age 65 ± 11 years, diabetes duration 7 ± 8 years) were followed up between 2004 and 2011. Each patient was analyzed step-by-step until either eventually starting insulin treatment or getting to the end of the follow-up period. Patients switching to insulin showed a worse global risk profile, longer disease duration (10 ± 9 years vs...
2018: Journal of Diabetes Research
Marnix J M van Agtmaal, Alfons J H M Houben, Vera de Wit, Ronald M A Henry, Nicolaas C Schaper, Pieter C Dagnelie, Carla J van der Kallen, Annemarie Koster, Simone J Sep, Abraham A Kroon, Jacobus F A Jansen, Paul A Hofman, Walter H Backes, Miranda T Schram, Coen D A Stehouwer
OBJECTIVE: Structural brain abnormalities are key risk factors for brain diseases, such as dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain abnormalities already occur in prediabetes. Therefore, we investigated whether both prediabetes and type 2 diabetes are associated with lacunar infarcts (LIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and brain atrophy. RESEARCH DESIGN AND METHODS: We used data from 2,228 participants (1,373 with normal glucose metabolism [NGM], 347 prediabetes, and 508 type 2 diabetes (oversampled); mean age 59...
October 16, 2018: Diabetes Care
Anirban Maitra, Ayush Sharma, Randall E Brand, Stephen K Van Den Eeden, William E Fisher, Phil A Hart, Steven J Hughes, Kieren J Mather, Stephen J Pandol, Walter G Park, Ziding Feng, Jose Serrano, Jo Ann S Rinaudo, Sudhir Srivastava, Suresh T Chari
The National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases initiated the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) in 2015 (the CPDPC's origin, structure, governance, and research objectives are described in another article in this journal). One of the key objectives of CPDPC is to assemble a cohort of 10,000 subjects 50 years or older with new-onset diabetes, called the NOD cohort. Using a define, enrich, and find early detection approach, the aims of the NOD study are to (a) estimate the 3-year probability of pancreatic ductal adenocarcinoma (PDAC) in NOD (define), (b) establish a biobank of clinically annotated biospecimens from presymptomatic PDAC and control new-onset type 2 diabetes mellitus subjects, (c) conduct phase 3 validation studies of promising biomarkers for identification of incident PDAC in NOD patients (enrich), and (d) provide a platform for development of a future interventional screening protocol for early detection of PDAC in patients with NOD that incorporates imaging studies and/or clinical algorithms (find)...
November 2018: Pancreas
Katarzyna Piechowiak, Agnieszka Szypowska
AIMS: The aim of this study was to identify the physiological factors influencing diabetes control in children with type 1 diabetes (T1D) using continuous subcutaneous insulin infusion (CSII) from diabetes diagnosis. MATERIALS AND METHODS: This study focused on 163 children (81 boys) initiated with CSII within 2 weeks after T1D recognition and treated for at least 3 years. We analysed: fasting C-peptide, GADA, ICA, IA2A, BMI z-score, total daily dose, and basal insulin...
October 16, 2018: Diabetes/metabolism Research and Reviews
Charlene C Quinn, Krystal K Swasey, Jamila M Torain, Michelle D Shardell, Michael L Terrin, Erik A Barr, Ann L Gruber-Baldini
BACKGROUND: Type 2 diabetes (T2D) is a major chronic condition requiring management through lifestyle changes and recommended health service visits. Mobile health (mHealth) is a promising tool to encourage self-management, but few studies have investigated the impact of mHealth on health care utilization. OBJECTIVE: The objective of this analysis was to determine the change in 2-year health service utilization and whether utilization explained a 1.9% absolute decrease in glycated hemoglobin (HbA1c ) over 1-year in the Mobile Diabetes Intervention Study (MDIS)...
October 15, 2018: JMIR MHealth and UHealth
Eliane C Jorge, Edson N Jorge, Mayra Botelho, Joyce G Farat, Gianni Virgili, Regina El Dib
BACKGROUND: Diabetic macular oedema (DMO) is a complication of diabetic retinopathy and one of the most common causes of visual impairment in people with diabetes. Clinically significant macular oedema (CSMO) is the most severe form of DMO. Intravitreal antiangiogenic therapy is now the standard treatment for DMO involving the centre of the macula, but laser photocoagulation is still used in milder or non-central DMO. OBJECTIVES: To access the efficacy and safety of laser photocoagulation as monotherapy in the treatment of diabetic macular oedema...
October 15, 2018: Cochrane Database of Systematic Reviews
A Mantovani, E Sani, A Fassio, A Colecchia, O Viapiana, D Gatti, L Idolazzi, M Rossini, G Salvagno, G Lippi, G Zoppini, C D Byrne, E Bonora, Giovanni Targher
AIM: Information is lacking on the association between non-alcoholic fatty liver disease (NAFLD) and bone mineral density (BMD) or circulating bone turnover biomarkers in post-menopausal women with type 2 diabetes (T2DM). METHODS: We recruited 77 white post-menopausal women with T2DM, who consecutively attended our diabetes outpatient service during a 3-month period. Ultrasonography and transient elastography (Fibroscan® ) were used for diagnosing and staging NAFLD...
October 10, 2018: Diabetes & Metabolism
Daniela Guarino, Diego Moriconi, Andrea Mari, Eleni Rebelos, Daria Colligiani, Simona Baldi, Marco Anselmino, Ele Ferrannini, Monica Nannipieri
AIMS/HYPOTHESIS: Postprandial hypoglycaemia (PPHG) is a complication of Roux-en-Y gastric bypass (RYGB) surgery in normoglycaemic individuals. In type 2 diabetes, RYGB improves glucose metabolism, but whether this improvement is related to the later development of PPHG is not known. We investigated the presence and mechanisms of PPHG in individuals with type 2 diabetes undergoing RYGB. METHODS: A total of 35 obese individuals with type 2 diabetes underwent an OGTT before and 24 months after surgery...
October 12, 2018: Diabetologia
Radoslaw Slopien, Ewa Wender-Ozegowska, Anita Rogowicz-Frontczak, Blazej Meczekalski, Dorota Zozulinska-Ziolkiewicz, Jesse D Jaremek, Antonio Cano, Peter Chedraui, Dimitrios G Goulis, Patrice Lopes, Gita Mishra, Alfred Mueck, Margaret Rees, Levent M Senturk, Tommaso Simoncini, John C Stevenson, Petra Stute, Pauliina Tuomikoski, Stavroula A Paschou, Panagiotis Anagnostis, Irene Lambrinoudaki
INTRODUCTION: Whether menopause increases the risk of type 2 diabetes mellitus (T2DM) independently of ageing has been a matter of debate. Controversy also exists about the benefits and risks of menopausal hormone therapy (MHT) in women with T2DM. AIMS: To summarise the evidence on 1) the effect of menopause on metabolic parameters and the risk of T2DM, 2) the effect of T2DM on age at menopause, 3) the effect of MHT on the risk of T2DM, and 4) the management of postmenopausal women with T2DM...
November 2018: Maturitas
Miguel Moyses-Neto, Bruno Rafael Santos Brito, Dyego José de Araújo Brito, Noelia Dias Carneiro Barros, Márcio Dantas, Natalino Salgado-Filho, Roberto Silva Costa, Gyl Eanes Barros Silva
BACKGROUND: Ingestion of vitamin C is generally regarded as harmless. Oxalate nephropathy is an infrequent condition and is characterized by oxalate deposition in the renal tubules, in some cases resulting in acute kidney injury. It can be caused by overproduction of oxalate in genetic disorders and, more frequently, as a secondary phenomenon provoked by ingestion of oxalate or substances that can be transformed into oxalate in the patient. CASE PRESENTATION: We present a case of acute oxalate nephropathy in a 59-year-old black male with type 2 diabetes mellitus, who received a kidney transplant 11 years prior...
October 12, 2018: BMC Nephrology
Ahmed Al-Qaissi, Maria Papageorgiou, Zeeshan Javed, Tim Heise, Alan S Rigby, Andrew T Garrett, David Hepburn, Eric S Kilpatrick, Stephen L Atkin, Thozhukat Sathyapalan
OBJECTIVE: This study aimed to explore the effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes. RESEARCH DESIGN: A 3-way, cross-over, randomised study was performed in adults with type 1 diabetes mellitus (n=10). The pharmacodynamics profile of a single dose of short-acting insulin (insulin lispro) was investigated under three environmental conditions: i) temperature: 15°C and humidity: 10%, ii) temperature: 30°C and humidity: 10%, and iii) temperature: 30°C and humidity: 60%, controlled in an environmental chamber...
October 12, 2018: Diabetes, Obesity & Metabolism
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