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Type 3 C Diabetes

Daniela Bassi, Ramona Cabiddu, Renata G Mendes, Natália Tossini, Vivian M Arakelian, Flávia C R Caruso, José C Bonjorno Júnior, Ross Arena, Audrey Borghi-Silva
BACKGROUND: Type 2 diabetes Mellitus (T2DM) is associated with cardiac autonomic dysfunction, which is an independent predictor of mortality in chronic diseases. However, whether the coexistence of systemic arterial hypertension (HTN) with DMT2 alters cardiac autonomic modulation remains unknown. OBJECTIVE: To evaluate the influence of HTN on cardiac autonomic modulation and cardiorespiratory fitness in subjects with DMT2. METHODS: 60 patients of both genders were evaluated and allocated to two groups: DMT2 patients (n = 32; 51 ± 7...
July 2018: Arquivos Brasileiros de Cardiologia
Arwen W Gao, Mark G Sterken, Jelmi Uit de Bos, Jelle van Creij, Rashmi Kamble, Basten L Snoek, Jan E Kammenga, Riekelt H Houtkooper
Metabolic homeostasis is sustained by complex biological networks that respond to nutrient availability. Genetic and environmental factors may disrupt this equilibrium, leading to metabolic disorders, including obesity and type 2 diabetes. To identify the genetic factors controlling metabolism, we performed quantitative genetic analysis using a population of 199 recombinant inbred lines (RILs) in the nematode Caenorhabditis elegans We focused on the genomic regions that control metabolite levels by measuring fatty acid (FA) and amino acid (AA) composition in the RILs using targeted metabolomics...
August 14, 2018: Genome Research
Adriana L Carvalho, Bianca Massaro, Luciana T P E Silva, Carlos E G Salmon, Sandra Y Fukada, Marcello H Nogueira-Barbosa, Jorge Elias, Maria C F Freitas, Carlos E B Couri, Maria C Oliveira, Belinda P Simões, Clifford J Rosen, Francisco J A de Paula
Anthropomorphic measures among type 1 diabetic patients are changing as the obesity epidemic continues. Excess fat mass may impact bone density and ultimately fracture risk. We studied the interaction between bone and adipose tissue in type 1 diabetes subjects submitted to two different clinical managements: (I) conventional insulin therapy or (II) autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST). The study comprised 3 groups matched by age, gender, height and weight: control (C = 24), type 1 diabetes (T1D = 23) and type 1 diabetes treated with AHST (T1D-AHST = 9)...
July 5, 2018: Journal of Clinical Densitometry
S Borys, J Hohendorff, T Koblik, P Witek, A H Ludwig-Slomczynska, C Frankfurter, B Kiec-Wilk, M T Malecki
PURPOSE: Negative pressure wound therapy (NPWT) is an adjunct method used in the treatment of diabetic foot ulceration (DFU). Real world data on its effectiveness and safety is scarce. In this prospective observational study, we assessed the short-term efficacy, safety, and long-term outcomes of NPWT in patients with type 2 diabetes (T2DM) and neuropathic, noninfected DFUs. METHODS: Based on wound characteristics, mainly area (>1 vs. ≤1 cm2 ), 75 patients with DFUs treated in an outpatient clinic were assigned to NPWT (n = 53) or standard therapy (n = 22)...
August 11, 2018: Endocrine
Katherine V Williams, Christina L Cristaldi, Rachel G Miller, Vincent C Arena, Ingrid Libman, Yihe Huang, Dorothy J Becker, Trevor J Orchard
Context: Though the long-term consequences of celiac disease (CD) in type 1 diabetes are unclear, CD has been associated with increased prevalence of end-stage renal disease (ESRD) independent of type 1 diabetes. Objective: We evaluated whether celiac autoimmunity is related to the cumulative incidence of microalbuminuria (AER 20-200µg/min), macroalbuminuria (AER>200µg/min), and ESRD. Design, Patients, and Methods: In the prospective follow-up of the Pittsburgh Epidemiology of Diabetes Complications (EDC) study of childhood onset type 1 diabetes, 618 participants were screened for tissue transglutaminase antibodies (tTG) antibodies with a clinical assay...
August 6, 2018: Journal of Clinical Endocrinology and Metabolism
D Vázquez-Justes, J Sanahuja, J Diez, E Rubinat, R Begué, C Salas, C Vicandi, M I Gil, F Purroy, D Mauricio
OBJECTIVE: To study the frequency and management of incidental findings in nonenhanced brain MRI of a middle-aged population of type 2 diabetic patients. METHODS: We retrospectively analyzed the results of 289 brain MRI obtained from subjects between 40-75 years recruited from a previous study. Incidental findings were classified into three categories: 1) Vascular findings; 2) neoplastic findings; and 3) others. On the other side, we made a classification of referral findings...
August 8, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
Jing Han, Yue Huang, Xinyu Chen, Feng Zhou, Yingying Fei, Junjie Fu
Dimerization is viewed as an effective means to enhance the binding affinity and therapeutic potency of peptides. Both dimerization and lipidation effectively prolong the half-life of peptides in vivo by increasing hydrodynamic size and facilitating physical interactions with serum albumin. Here, we report a novel method to discover long-acting glucagon-like peptide 1 (GLP-1) analogues by rational design based on Xenopus GLP-1 through a combined dimerization and lipidization strategy. On the basis of our previous structure analysis of Xenopus GLP-1, palmitic acid and a C-terminal Cys were firstly introduced into two Xenopus GLP-1 analogues (1 and 2), and the afforded 3 and 4 were further reacted with bis-maleimide amine to afford two dimeric lipidated Xenopus GLP-1 analogues (5 and 6)...
August 3, 2018: European Journal of Medicinal Chemistry
Vivian K Lee, Brett M Hosking, Joanna Holeniewska, Ewa C Kubala, Peter Lundh von Leithner, Peter J Gardner, Richard H Foxton, David T Shima
AIMS/HYPOTHESIS: Diabetic retinopathy is increasing in prevalence worldwide and is fast becoming a global epidemic and a leading cause of visual loss. Current therapies are limited, and the development of effective treatments for diabetic retinopathy requires a greater in-depth knowledge of disease progression and suitable modelling of diabetic retinopathy in animals. The aim of this study was to assess the early pathological changes in retinal morphology and neuronal, inflammatory and vascular features consistent with diabetic retinopathy in the ob/ob mouse model of type 2 diabetes, to investigate whether features similar to those in human diabetic retinopathy were present...
August 9, 2018: Diabetologia
Cheng Cheng, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Ming Zhang, Dongdong Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dechen Liu, Junmei Zhou, Xuejiao Liu, Leilei Liu, Xu Chen, Feiyan Liu, Qionggui Zhou, Dongsheng Hu
BACKGROUND: Evidence shows that high triglycerides (TG) level and low high-density lipoprotein cholesterol (HDL-C) level are traditional risk factors for type 2 diabetes mellitus (T2DM). The present study evaluated the dose-response relation between TG/HDL ratio and risk of T2DM. METHODS: We included 11946 adults without baseline diabetes from the Rural Chinese Cohort Study. Cox proportional-hazards regression was used to investigate the association of TG/HDL ratio and T2DM...
August 9, 2018: Journal of Diabetes
Carmella Evans-Molina, Emily K Sims, Linda A DiMeglio, Heba M Ismail, Andrea K Steck, Jerry P Palmer, Jeffrey P Krischer, Susan Geyer, Ping Xu, Jay M Sosenko
BACKGROUND: The duration and patterns of β cell dysfunction during type 1 diabetes (T1D) development have not been fully defined. METHODS: Metabolic measures derived from oral glucose tolerance tests (OGTTs) were compared between autoantibody-positive (aAb+) individuals followed in the TrialNet Pathway to Prevention study who developed diabetes after 5 or more years or less than 5 years of longitudinal follow-up (Progressors≥5, n = 75; Progressors<5, n = 474) and 144 aAb-negative (aAb-) relatives...
August 9, 2018: JCI Insight
Pia Christensen, Thomas Meinert Larsen, Margriet Westerterp-Plantenga, Ian Macdonald, J Alfredo Martinez, Svetoslav Handjiev, Sally Poppitt, Sylvia Hansen, Christian Ritz, Arne Astrup, Laura Pastor-Sanz, Finn Sandø-Pedersen, Kirsi H Pietiläinen, Jouko Sundvall, Mathijs Drummen, Moira A Taylor, Santiago Navas-Carretero, Teodora Handjieva-Darlenska, Shannon Brodie, Marta P Silvestre, Maija Huttunen-Lenz, Jennie Brand-Miller, Mikael Fogelholm, Anne Raben
AIMS: The PREVIEW lifestyle intervention study ( Identifier: NCT01777893) is, to date, the largest, multinational study concerning prevention of type-2 diabetes. We hypothesized that the initial, fixed low-energy diet (LED) would induce different metabolic outcomes in men vs women. MATERIALS AND METHODS: All participants followed a LED (3.4 MJ/810 kcal/daily) for 8 weeks (Cambridge Weight Plan). Participants were recruited from 8 sites in Europe, Australia and New Zealand...
August 7, 2018: Diabetes, Obesity & Metabolism
Katia M Perez, Kathleen L Curley, James C Slaughter, Ashley H Shoemaker
Context: Pseudohypoparathyroidism (PHP) is a rare, genetic disorder characterized by early-onset obesity and multi-hormone resistance. To treat abnormal weight gain and prevent complication such as diabetes, we must understand energy balance and glucose homeostasis in PHP, type 1A and 1B. Objective: The aim of this study was to evaluate food intake, energy expenditure and glucose homeostasis in children with PHP. Design: Assessments included resting energy expenditure (REE), physical activity, food intake, sucrose preference, questionnaires, endocrine and auxological status...
August 3, 2018: Journal of Clinical Endocrinology and Metabolism
B Parsons, C Li, B Emir, A I Vinik
OBJECTIVE: The objective of this manuscript is to compare pregabalin's efficacy and safety for painful diabetic peripheral neuropathy (pDPN) in subjects with type 1 (T1DM) or 2 diabetes mellitus (T2DM). METHODS: Pooled data from 10 randomized clinical trials (pregabalin-treated T1DM and T2DM subjects with pDPN) were analyzed for change from baseline (CFB) scores (pain and sleep disturbance) using mixed model repeated measures (MMRM) through Week 12 and last observation carried forward (LOCF)...
August 7, 2018: Current Medical Research and Opinion
Ji Cheol Bae, Kyung Wan Min, Yong Hyun Kim, Kyoung-Ah Kim, Eun-Gyoung Hong, Cheol-Young Park, Song Han, Bong-Soo Cha
OBJECTIVE: To evaluate the efficacy and safety of a fixed-dose combination (FDC) of gemigliptin/rosuvastatin in patients with type 2 diabetes and dyslipidaemia. RESEARCH DESIGN AND METHODS: Thirty-three hospitals in Korea participated in this randomized, double-blind trial of diabetic patients with dyslipidaemia. Two hundred ninety participants were randomly assigned at a 1:1:1 ratio to receive a FDC of gemigliptin (50 mg)/rosuvastatin (20 mg) (GEMI/ROSU FDC group), gemigliptin (50 mg) (GEMI group), or rosuvastatin (20 mg) (ROSU group)...
August 6, 2018: Diabetes, Obesity & Metabolism
Miao Wang, Xuejiao Tang, Ling Li, Dongfang Liu, Hua Liu, Hongting Zheng, Wuquan Deng, Xili Zhao, Gangyi Yang
AIMS: C1q/tumor necrosis factor-related protein-6 (CTRP6) is a novel adipokine and has emerged as an important mediator for lipid and glucose metabolism. However, to date, the relationship between CTRP6 and T2DM in humans has not been demonstrated. Our objective is to investigate the association of circulating CTRP6 with T2DM in a cross-sectional study. METHODS: 118 patients with newly diagnosed T2DM, 98 subjects with impaired glucose tolerant (IGT) and 132 healthy subjects were recruited for this study...
August 7, 2018: Acta Diabetologica
Y S Zhang, W Y Weng, B C Xie, Y Meng, Y H Hao, Y M Liang, Z K Zhou
Our network meta-analysis analyzed the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on fracture risk. By combining data from randomized controlled trials, we found that GLP-1 RAs were associated with a decreased bone fracture risk, and exenatide is the best option agent with regard to the risk of fracture. This study is registered with PROSPERO (CRD42018094433). INTRODUCTION: Data on the effects of GLP-1 RAs on fracture risk are conflicted. This study aimed to analyze the available evidence on the effects of GLP-1 RAs on fracture risk in type 2 diabetes mellitus patients...
August 6, 2018: Osteoporosis International
Jin J Zhou, Dawn C Schwenke, Gideon Bahn, Peter Reaven
OBJECTIVE: There is uncertainty about the importance of glycemic variability in cardiovascular complications in patients with type 2 diabetes. Using the Veteran Affairs Diabetes Trial (VADT), we investigated the association between variation in fasting glucose and glycated hemoglobin (HbA1c ) over time with the incidence of cardiovascular disease (CVD) and assessed whether this is influenced by intensive or standard glycemic control. RESEARCH DESIGN AND METHODS: During the VADT, fasting glucose and HbA1c were measured every 3 months for up to 84 months in 1,791 individuals...
August 6, 2018: Diabetes Care
Dan Rujescu, Annette M Hartmann, Ina Giegling, Bettina Konte, Marko Herrling, Susanne Himmelein, Michael Strupp
Objective: In order to identify genetic variants associated with vestibular neuritis, a common cause of peripheral vertigo with a potential causative link to the reactivation of herpes simplex type 1 (HSV-1), we conducted a genome-wide association study. Methods: Association was assessed using approximately 8 million variants. 131 patients with vestibular neuritis and 2,609 controls of European ancestry were included. Results: Genome-wide associations with vestibular neuritis were detected in 4 regions containing protein coding genes assignable to two functional groups: virus hypothesis and insulin metabolism...
2018: Frontiers in Neurology
Ravi Gupta, Munish Sood, Anubhav Malhotra, Gladson David Masih, Mukta Raghav, Tanu Khanna
Background: Infection after anterior cruciate ligament reconstruction surgery (ACLRS) is a rare complication. Although there are number of studies from various Caucasian population but only few studies are available from Asian population. The aim of the study is to assess the incidence, risk factors and, clinical outcome using our treatment protocol. Materials and Methods: Out of 1468 arthroscopic ACLRS, 26 patients with clinical suspicion of infection were critically analysed in terms of laboratory reports of arthrocentesis, erythrocyte sedimentation rate, C-reactive protein and risk factors such as the type of graft, gender, diabetes mellitus, smoking, intraarticular steroid injection, and obesity...
July 2018: Indian Journal of Orthopaedics
Roy Taylor, Ahmad Al-Mrabeh, Sviatlana Zhyzhneuskaya, Carl Peters, Alison C Barnes, Benjamin S Aribisala, Kieren G Hollingsworth, John C Mathers, Naveed Sattar, Michael E J Lean
The Diabetes Remission Clinical Trial reported return and persistence of non-diabetic blood glucose control in 46% of people with type 2 diabetes of up to 6 years duration. Detailed metabolic studies were performed on a subgroup (intervention, n = 64; control, n = 26). In the intervention group, liver fat content decreased (16.0% ± 1.3% to 3.1% ± 0.5%, p < 0.0001) immediately after weight loss. Similarly, plasma triglyceride and pancreas fat content decreased whether or not glucose control normalized...
August 2, 2018: Cell Metabolism
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