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Oxygen reserve index

Shih-Hao Huang, Yu-Wei Lin
Monitoring dynamic changes in oxygen consumption rates (OCR) of a living organism in real time provide an indirect method of monitoring changes in mitochondrial function during development, aging, or malfunctioning processes. In this study, we developed a microfluidic device integrated with an optical detection system to measure the OCR of a single developing Caenorhabditis elegans ( C. elegans ) from postembryonic development to aging stages in real time via phase-based phosphorescence lifetime measurement...
July 28, 2018: Sensors
Graziele Mendes, Ludmila de Matos Baltazar, Daniele da Glória de Souza, Nívea Pereira de Sá, Luiz Henrique Rosa, Carlos Augusto Rosa, Elaine Maria Souza-Fagundes, Jonas Ramos Pereira, Juliana Alves-Silva, Betania Barros Cota, Susana Johann
AIMS: To determine the effects of cytochalasin E, isolated from the extremophile fungus Aspergillus felis, on the cells of Paracoccidioides brasiliensis Pb18. METHODS AND RESULTS: Cytochalasin E showed a minimal inhibitory concentration of 3.6 μmol l-1 and minimum fungicidal concentration of 7.2 μmol l-1 on P. brasiliensis by in vitro microdilution and IC50 > 964.0 μmol l-1 on murine macrophages. Its selectivity index (> 263) indicated that this compound has selectivity for fungal cells...
July 27, 2018: Journal of Applied Microbiology
Bernd Saugel, F Javier Belda
No abstract text is available yet for this article.
July 9, 2018: Minerva Anestesiologica
Masaru Obokata, Yogesh N V Reddy, Vojtech Melenovsky, Garvan C Kane, Thomas P Olson, Petr Jarolim, Barry A Borlaug
BACKGROUND: Cardiac reserve is depressed in patients with heart failure and preserved ejection fraction (HFpEF). The mechanisms causing this are poorly understood. OBJECTIVES: The authors hypothesized that myocardial injury might contribute to the hemodynamic derangements and cardiac reserve limitations that are present in HFpEF. Markers of cardiomyocyte injury, central hemodynamics, ventricular function, and determinants of cardiac oxygen supply-demand balance were measured...
July 3, 2018: Journal of the American College of Cardiology
Eva E Buschmann, Philipp Hillmeister, Anja Bondke Persson, David S Liebeskind, Lea Schlich, Robert Kamenzky, Andreas Busjahn, Ivo R Buschmann, Peter Bramlage, Andreas Hetzel, Matthias Reinhard
BACKGROUND: External counterpulsation improves cerebral perfusion velocity in acute stroke and may stimulate collateral artery growth. However, whether (non-acute) at-risk patients with high-grade carotid artery disease may benefit from counterpulsation needs to be validated. METHODS: Twenty-eight patients (71±6.5 years, 5 women) with asymptomatic unilateral chronic severe ICA stenosis (>70%) or occlusion were randomized to receive 20 min active counterpulsation followed by sham treatment or vice versa...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Agnieszka Gunia-Krzyżak, Karolina Słoczyńska, Justyna Popiół, Paulina Koczurkiewicz, Henryk Marona, Elżbieta Pękala
Cinnamic acid derivatives are widely used in cosmetics and possess various functions. This group of compounds includes both naturally occurring as well as synthetic substances. On the basis of the Cosmetic Ingredient Database (CosIng) and available literature, this review summarizes their functions in cosmetics, including their physicochemical and biological properties as well as reported adverse effects. A perfuming function is typical of many derivatives of cinnamaldehyde, cinnamyl alcohol, dihydrocinnamyl alcohol, and cinnamic acid itself; these substances are commonly used in cosmetics all over the world...
June 5, 2018: International Journal of Cosmetic Science
M J Mebius, S A B Clur, A S Vink, E Pajkrt, W S Kalteren, E M W Kooi, A F Bos, G J du Marchie Sarvaas, C M Bilardo
OBJECTIVES: Congenital heart disease (CHD) has been associated with a reduced fetal head circumference (HC). The underlying pathophysiological background remains undetermined. We aimed to define trends in fetal growth and cerebro-placental Doppler flow, and to investigate the association between head growth and cerebro-placental flow in fetuses with CHD. METHODS: Fetuses with CHD and serial measurements of HC, abdominal circumference (AC), middle cerebral artery pulsatility index (MCA-PI), umbilical artery pulsatility index (UA-PI), and cerebro-placental ratio (CPR) were included...
May 28, 2018: Ultrasound in Obstetrics & Gynecology
D J Ramos-Campo, I Martínez-Guardado, G Olcina, C Marín-Pagán, F J Martínez-Noguera, J Carlos-Vivas, P E Alcaraz, J Á Rubio
Recent acute studies have shown that high-intensity resistance circuit-based (HRC) training in hypoxia increases metabolic stress. However, no intervention studies have yet proven their effectiveness. This study aimed to analyze the effect of 8 weeks of HRC in hypoxia on aerobic performance, resting energy expenditure (REE), repeat sprint ability (RSA) and hematological variables. Twenty-eight subjects were assigned to hypoxia (FiO2  = 15%; HRChyp : n = 15; age: 24.6 ± 6.8 years; height: 177.4 ± 5...
May 23, 2018: Scandinavian Journal of Medicine & Science in Sports
Wakana Koishi, Motoi Kumagai, Shohei Ogawa, Shuhei Hongo, Kenji Suzuki
BACKGROUND: Hypoxemia can occur during one-lung ventilation (OLV), but monitoring blood oxygenation using percutaneous oxygen saturation (SpO2) can be limited by detection latency, and SpO2 sometimes does not change during OLV. The Oxygen Reserve Index (ORiTM) is a novel index reported to detect impending desaturation before this is observed with SpO2 monitoring. This study assessed whether the ORi decreased earlier than SpO2 during OLV and evaluated its correlation with the partial pressure of arterial oxygen (PaO2) during OLV...
May 14, 2018: Minerva Anestesiologica
Emma Williams, Theodore Dassios, Paul Clarke, Olie Chowdhury, Anne Greenough
AIM: To determine how oxygenation, ventilation efficiency and tidal volume requirements changed with the development of pulmonary interstitial emphysema (PIE) and whether in affected patients a composite gas exchange index predicted death or bronchopulmonary dysplasia (BPD). METHODS: Infants who developed PIE from 2010 to 2016 were identified. The oxygenation index (OI), ventilation efficiency index (VEI), ventilation to perfusion ratio and inspiratory tidal volume were calculated before radiological evidence of PIE (pre-PIE) and at the worst PIE radiographic appearance (PIE-worst)...
May 13, 2018: Acta Paediatrica
Barbara J Morgan, Mihaela Teodorescu, David F Pegelow, Emily R Jackson, Devin L Schneider, David T Plante, James P Gapinski, Scott J Hetzel, John M Dopp
NEW FINDINGS: What is the central question of this study? In sleep apnoea, a putative link between intermittent hypoxia and hypertension is the generation of oxygen radicals by angiotensin II and xanthine oxidase within the chemoreflex arc and vasculature. We tested whether chemoreflex control of sympathetic outflow, hypoxic vasodilatation and blood pressure are altered by angiotensin blockade (losartan) and/or xanthine oxidase inhibition (allopurinol). What is the main finding and its importance? Both drugs lowered blood pressure without altering sympathetic outflow, reducing chemoreflex sensitivity or enhancing hypoxic vasodilatation...
July 2018: Experimental Physiology
Marjan Khazan PhD, Mehdi Hedayati PhD, Reza M Robati Md, Seyed Mohammad Riahi PhD, Soheila Nasiri
Oxidative stress, caused by an imbalance between reactive oxygen species and antioxidants, is related to many dermatologic diseases. Increased reactive oxygen species is also associated with various decreased T-cell immune responses. The incidence and severity of herpes zoster (HZ), which is caused by the reactivation of varicella-zoster virus, increase with age because of declining cell-mediated immunity. The main purpose of this study was to assess the levels of oxidative stress biomarkers in patients with HZ compared with control subjects...
April 28, 2018: Journal of Medical Virology
Gregory D Arnone, Ziad A Hage, Fady T Charbel
In this 3-dimensional video, we perform a side-to-side and end-to-side double anastomosis using the parietal-branch of the superficial temporal artery (STA) to provide flow augmentation in a symptomatic 59-yr-old male with bilateral internal carotid artery occlusion at the origin, and left M1 segment occlusion. The patient suffered multiple left hemispheric strokes despite maximal medical therapy and was found to have poor hemodynamic reserve in the left hemisphere during evaluation with regional and global blood oxygenation level-dependent functional magnetic resonance imaging with CO2-challenge as well as quantitative magnetic resonance angiography and noninvasive optimal vessel analysis pre- and post-acetazolamide challenge...
April 12, 2018: Operative Neurosurgery (Hagerstown, Md.)
Magdalena Więcek, Jadwiga Szymura, Marcin Maciejczyk, Zbigniew Szyguła, Jerzy Cempla, Mateusz Borkowski
OBJECTIVES: The aim of the study is to evaluate the intensity of the effort and energy expenditure in the course of performing selected classical massage techniques and to assess the workload of a massage therapist during a work shift. MATERIAL AND METHODS: Thirteen massage therapists (age: 21.9±1.9 years old, body mass index: 24.5±2.8 kg×m<sup>-2</sup>, maximal oxygen consumption × body mass<sup>-1</sup> (VO<sub>2 max</sub>×BM<sup>-1</sup>): 42...
April 11, 2018: International Journal of Occupational Medicine and Environmental Health
Swarup Ray, Ketan Sakharam Kulkarni, Nandini Malay Dave, Indrani Chincholi
No abstract text is available yet for this article.
March 2018: Indian Journal of Anaesthesia
Y P Wang, S H Yao, D Liu, T Shen, W Zhao, W Gao, S L Xu
Objective: To determine the relative percentage of skeletal muscle mass (SMM) in elderly patients with coronary heart disease, analyse the relationship between percentage of SMM and cardiorespiratory fitness (CRF), predict exercise capacity and cardiac reserve. Methods: Patients aged 65 years and over after PCI, receiving cardiopulmonary exercise testing (CPET) during February 2014 to December 2016 in Department of Cardiology at Peking University Third Hospital were enrolled.All patients' basic data, percentage of SMM and CPET related parameters, including peak oxygen uptake (VO(2)peak), oxygen pulse (VO(2)/HR), oxygen uptake efficiency slope (OUES) and other cardiorespiratory endurance indicators were collected, to do correlation analysis...
March 20, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Corey R Hart, Gwenael Layec, Joel D Trinity, Oh Sung Kwon, Jia Zhao, Van R Reese, Jayson R Gifford, Russell S Richardson
NEW FINDINGS: What is the central question of this study? What is the degree to which skeletal muscle mitochondria-derived reactive oxygen species (ROS) production is linked to impaired skeletal muscle function in patients with early-stage peripheral arterial disease (PAD) and what is the impact on mitochondrial respiratory capacity? What is the main finding and its importance? This is the first study to document increased mitochondria-derived reactive oxygen species production associated with elevated intramuscular oxidative stress, despite preserved mitochondrial respiratory function, in patients with PAD...
June 2018: Experimental Physiology
E H Van Iterson, J R Smith, T P Olson
AIM: In contrast to knowledge that heart failure (HF) patients demonstrate peak exercise uncoupling across ventilation, gas exchange and cardiac haemodynamics, whether this dyssynchrony follows that at the exercise on-transition is unclear. This study tested whether exercise on-transition temporal lag for ventilation relative to gas exchange and oxygen pulse (O2 pulse) couples with effects from abnormal pulmonary gaseous oxygen store (O2store ) contributions to V˙O2 to interdependently precipitate persistently elevated ventilatory demand and low oxidative metabolic capacity in HF...
August 2018: Acta Physiologica
He Zhao, Jiaywei Tsauo, Xiaowu Zhang, Huaiyuan Ma, Ningna Weng, Luhua Wang, Xiao Li
BACKGROUND & AIMS: Pulmonary transit time (PTT) is the transit time of blood from the right side of the heart to the left side of the heart. The aim of the present study was to evaluate the role of the PTT derived from pulmonary angiography in the diagnosis of hepatopulmonary syndrome (HPS). METHODS: From December 2014 to September 2015, all patients with chronic liver disease and/or portal hypertension undergoing a venous interventional radiologic procedure at our institution were eligible for inclusion in this prospective study...
March 24, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Timothy J Roberts, Andrew T Burns, Richard J MacIsaac, Andrew I MacIsaac, David L Prior, André La Gerche
BACKGROUND: The reasons for reduced exercise capacity in diabetes mellitus (DM) remains incompletely understood, although diastolic dysfunction and diabetic cardiomyopathy are often favored explanations. However, there is a paucity of literature detailing cardiac function and reserve during incremental exercise to evaluate its significance and contribution. We sought to determine associations between comprehensive measures of cardiac function during exercise and maximal oxygen consumption ([Formula: see text]peak), with the hypothesis that the reduction in exercise capacity and cardiac function would be associated with co-morbidities and sedentary behavior rather than diabetes itself...
March 23, 2018: Cardiovascular Diabetology
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