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Prabha Siddarth, Alison C Burggren, David A Merrill, Linda M Ercoli, Zanjbeel Mahmood, Jorge R Barrio, Gary W Small
BACKGROUND: The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with the apolipoprotein E (APOE) gene, has been implicated in Alzheimer's disease (AD). TOMM40 influences AD pathology through mitochondrial neurotoxicity, and the medial temporal lobe (MTL) is the most likely brain region for identifying early manifestations of AD-related morphology changes. While early reports indicated that the longer length poly-T allele of TOMM40 increases risk for AD, these findings have not been consistently replicated in further studies...
2018: PloS One
Soutick Nandi, Ena Sharma, Vishal Trivedi, Shyam Biswas
In this work, we report a new hydrazine-functionalized Al(III)- based metal-organic framework having MIL-53 (MIL = Material of Institute Lavoisier) framework topology for the sensitive and selective detection of formaldehyde (FA). The phase purity of the thermally activated and as-synthesized forms of the material was examined by X-ray powder diffraction experiments, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The desolvated material (1') showed great potential for the selective sensing of FA in the existence of other potentially competitive aldehydes in both aqueous and 10 mM HEPES buffer (pH = 7...
December 5, 2018: Inorganic Chemistry
Jiaojiao Tang, Silin Chen, Lie Liu, Hongtao Liao, Xianzhang Zhan, Shulin Wu, Yuanhong Liang, Oudi Chen, Chunying Lin, Qianhuan Zhang, Huiqiang Wei, Dongli Chen
The study described here aimed to evaluate left ventricular (LV) systolic mechanical synchronization during permanent selective His bundle pacing (SHBP) using 3-D speckle-tracking echocardiography post-operatively and 6 mo after pacemaker implantation in 62 patients randomly assigned to SHBP (n = 32) or right ventricular apical pacing (RVAP, n = 30). A standard apex four-chamber view was exposed and was transformed into full-volume mode under 3-D echocardiography. Three-dimensional speckle-tracking echocardiography was analyzed offline...
November 30, 2018: Ultrasound in Medicine & Biology
Somayya M Sadek, Reda A Ahmad, Hytham Atia, Adel G Abdullah
BACKGROUND: Measurement of edge to os distance (EOD) is essential to differentiate low-lying from normal placenta, and to plan for delivery. Till now, measurement by 2D TVS is the gold standard, however, its accuracy is questioned. In this study, we introduced an innovative technique for measurement of EOD using 3D TVS. Our aim was to compare EOD measurements of the standard 2D technique, to those of our innovative 3D technique, and to correlate the difference, if any, with placental site and internal os width...
December 4, 2018: BMC Pregnancy and Childbirth
Inge C Olsen, Elisabeth Lie, Radu Vasilescu, Gene Wallenstein, Sander Strengholt, Tore K Kvien
Objective: To describe the outcomes of MTX and biologic DMARD (bDMARD) treatment in patients with RA and assess unmet needs in patients who fail treatment, using real-world data from the Norwegian DMARD (NOR-DMARD) registry. Methods: Data included RA treatment courses from January 2007 until July 2016. Patients received MTX monotherapy (in MTX-naïve patients), bDMARD monotherapy, bDMARDs + MTX, or bDMARDs + other conventional synthetic DMARDs (csDMARDs). DAS28-4(ESR) was used to measure remission (<2...
November 30, 2018: Rheumatology
José M Otero-Mato, Hadrián Montes-Campos, Oscar Cabeza, Diddo Diddens, Alina Ciach, Luis J Gallego, Luis M Varela
Mixtures of the ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate with amphiphilic cosolvents, such as methanol and ethanol, nanoconfined between graphene walls are studied by means of molecular dynamics simulations and the results are compared with those of the pure ionic liquid and its mixtures with water confined in the same conditions. We investigate the adsorption of cosolvent molecules at the graphene walls as well as their distribution across the system. The results show that, due to a higher affinity of the polar groups to be close to the anions in combination with the electrostatic and excluded volume interactions, there exists a high tendency of the OH groups to lie close to the anode, inducing small changes in the first cation layer...
November 30, 2018: Physical Chemistry Chemical Physics: PCCP
Saleheh Taghvaee, Yaser Kasesaz, Mehdi Salehi Barough
Aims: The main objective of the present research is to analyze the caregiver effective dose during I-131 therapy of thyroid in some different situations using MCNP4C Monte Carlo code. Patients and Methods: Two separate whole body Medical Internal Radiation Dosimetry (MIRD) phantoms have been defined simultaneously in a single Monte Carlo N-Particle (MCNP) input file as the patient and the caregiver. Two different groups of irradiation situations have been assumed for the caregiver related to the patient, (1) both the patient and the caregiver are standing and (2) the patient is lying in the bed while the caregiver is standing beside the patient...
October 2018: Journal of Cancer Research and Therapeutics
Rosalind McCollum, Miriam Taegtmeyer, Lilian Otiso, Nelly Muturi, Edwine Barasa, Sassy Molyneux, Tim Martineau, Sally Theobald
BACKGROUND: Practices of power lie at the heart of policy processes. In both devolution and priority-setting, actors seek to exert power through influence and control over material, human, intellectual and financial resources. Priority-setting arises as a consequence of the needs and demand exceeding the resources available, requiring some means of choosing between competing demands. This paper examines the use of power within priority-setting processes for healthcare resources at sub-national level, following devolution in Kenya...
November 29, 2018: BMC Health Services Research
N Rajbongshi, D C Nath, L B Mahanta
Background: Awareness is the primary means to control breast cancer occurrence. The purpose of the present work is to study the risk of breast cancer occurrence in different age group, for the study area, Assam, India, by means of survival analysis techniques. Methods: Survival and hazard functions are key concepts in survival analysis for describing the distribution of event times. In the present research a new individialized model has been proposed for cumulative hazard function, taking gamma probability distribution as probability distribution of breast cancer occurrences...
November 28, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Eli Feiring, Astrid Eidesvik Lie
BACKGROUND: New approaches to control healthcare expenditures and increase access to quality care are required by decision-makers in high-income countries. One strategy is to reallocate tasks from doctors to nurses. Evidence suggests that quality, effectiveness and efficiency of task shifting are context sensitive and affected by implementation. However, little is known about implementability of task shifting in specialised healthcare. We aimed to identify factors perceived to influence implementation of doctor-to-nurse task shifting in a hospital setting and improve understanding of task shifting implementability by using theory-based frameworks for analysing behaviour...
November 27, 2018: BMC Health Services Research
Xiang Zhu, Chengcheng Tian, Haihong Wu, Yanyan He, Lin He, Hai Wang, Xiaodong Zhuang, Honglai Liu, Chungu Xia, Sheng Dai
The first study of rational synthesis of triazine-based nanoporous frameworks as electrocatalysts for CO2 reduction reaction (CO2RR) was presented. The resulting optimized framework with rich pyridinic nitrogen-containing sites can selectively reduce CO2 to CO in water with a high Faradaic efficiency of ca. 82% under a moderate overpotential of 560 mV. The key of our success lies in the use of pyridine-based backbones as sacrificial groups inside the triazine framework for in situ generation of CO2RR-active pyridinic N-doped sites during the high-temperature ZnCl2-promoted polymerization process...
November 28, 2018: ACS Applied Materials & Interfaces
Stanislao Grazioso, Giuseppe Di Gironimo, Bruno Siciliano
Mathematical modeling of soft robots is complicated by the description of the continuously deformable three-dimensional shape that they assume when subjected to external loads. In this article we present the deformation space formulation for soft robots dynamics, developed using a finite element approach. Starting from the Cosserat rod theory formulated on a Lie group, we derive a discrete model using a helicoidal shape function for the spatial discretization and a geometric scheme for the time integration of the robot shape configuration...
November 28, 2018: Soft Robotics
Karen D Ethans, Alan Casey, Mohamed Tarhoni, Mayur Nankar, Stella Entcheva
Study design: Double-blind, randomized cross-over placebo-controlled pilot study. Objectives: To determine the effects of tadalafil on systolic blood pressure (SBP), heart rate (HR), and dizziness of men with American Spinal Injury Association Impairment Scale-A (AIS-A) spinal cord injury (SCI) between cervical-4 (C4) and thoracic-5 (T5) levels. Setting: Outpatient rehabilitation clinic. Design: Double-blind, randomized cross-over placebo-controlled pilot study...
2018: Spinal Cord Series and Cases
M M Narayanan, Anish Kumar, S Thirunavukkarasu, C K Mukhopadhyay
An ultrasonic guided wave based methodology is developed for inspection of steam generator tubes of the prototype fast breeder reactor. To this aim, axisymmetric longitudinal mode (L(0,2)) at the frequency of 250 kHz is optimized using 3D-finite element simulation and experiments. The group velocity of mode L(0,2) at 250 kHz is found to be 5387 m/s. First, the long range propagation of the L(0,2) mode at 250 kHz is examined and the mode is found to propagate over a distance of 45.6 m with a sufficiently good SNR...
November 10, 2018: Ultrasonics
Yoko Satoh, Utaroh Motosugi, Yoshie Omiya, Hiroshi Onishi
OBJECTIVE: The purposes of this study were to evaluate the diagnostic performance of dedicated breast PET (dbPET) in cases of unexpected uptake and to define parameters associated with malignancy. MATERIALS AND METHODS: There are two types of high-resolution dbPET systems. One has two platelike detectors that compress the breast. This study was conducted with the other type, on which the patient lies prone and the breast hangs through a ring without compression...
November 26, 2018: AJR. American Journal of Roentgenology
F F Yan, A A Mohammed, G R Murugesan, H W Cheng
The objective of this study was to determine the effects of a dietary synbiotic inclusion on broiler bone health under daily cyclic heat stress. A total of 360 Ross 708 broilers were randomly assigned to 1 of 3 dietary treatments (8 replicates per treatment): a regular diet (control) and the regular diet mixed with a commercial synbiotic product at 0.5 (0.5X) or 1.0 (1.0X) g/kg. The synbiotic contains a prebiotic (fructooligosaccharides) and a probiotic mixture of 4 microbial strains (Enterococcus faecium, Pediococcus acidilactici, Bifidobacterium animalis, and Lactobacillus reuteri)...
November 24, 2018: Poultry Science
Nupur Kapoor Nerurkar, Arundhatee Sapre, Rahul Gosavi
BACKGROUND: Mucosal bridges (MBs) are rare laryngeal lesions that may cause dysphonia of varying degrees. We propose the existence of a third variant of MB besides thin and thick MBs, and have termed this as an incomplete mucosal bridge (IMB). The concept of an IMB has not been previously discussed in literature. Thin and thick MBs are attached anteriorly and posteriorly on the membranous vocal fold and may cause dysphonia because of their separate vibratory characteristics from the main vocal fold...
November 26, 2018: European Archives of Oto-rhino-laryngology
John F Jarrell, George A Vilos, Catherine Allaire, Susan Burgess, Claude Fortin, Robert Gerwin, Louise Lapensée, Robert H Lea, Nicholas A Leyland, Paul Martyn, Hassan Shenassa, Paul Taenzer
OBJECTIF: Améliorer La compréhension de la douleur pelvienne chronique (DPC) et fournir des directives cliniques factuelles qui bénéficieront aux fournisseurs de soins de santé primaires, aux obstétriciens-gynécologues et aux spécialistes de la douleur chronique. FARDEAU DE LA SOUFFRANCE: La DPC est une pathologie débilitante courante qui affecte les femmes. Elle est à l'origine d'importantes souffrances personnelles et de dépenses de santé considérables associées aux interventions, dont de multiples consultations et un grand nombre de traitements médicaux et chirurgicaux...
November 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Ji Chen, Ya Yan, Fengjuan Yuan, Jianbo Cao, Shanhua Li, Simon B Eickhoff, Jiaxing Zhang
While there have been multiple fMRI studies into the brain functional changes after acutely stimulated peripheral infection, knowledge for the effect of chronic peripheral infection on whole brain morphology is still quite limited. The present study was designed to investigate the brain structural and emotional changes after peripheral local infection initiated chronic systemic inflammation and the relationship between circulating inflammatory markers and brain grey matter. Specifically, in-vivo T2-weighted MRI was performed on rats with lipopolysaccharide (LPS)-induced chronic pulmonary inflammation (CPI) for 4 months and those without...
November 22, 2018: Brain, Behavior, and Immunity
Shanker Kalakotla, Naradala Jayarambabu, G Krishna Mohan, Rabiatul Basria S M N Mydin, V Ramamohan Gupta
Diabetes mellitus is one of the threatening, non-communicable and chronic ailments worldwide since ancient times to the current stage of human existence. The utilization of nanoparticles as a medicine in the treatment of diabetes is an attractive proposition. In the present study, herbal mediated cerium oxide nanoparticles (HMCeO2 NPs), herbal mediated silver nanoparticles (HMAg NPs) and Lawsonia intermix extract (LIE) was evaluated for them for in-vivo hypoglycemic effect and compared the potency. The resulting HMCeO2 NPs, HMAg NPs and Lawsonia inermis have been characterized by different analytical equipments such as X-ray Diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Particle size analyzer (PSA), Field emission scanning electron microscope (FESEM) and High resolution transmission electron microscope (HRTEM)...
November 13, 2018: Colloids and Surfaces. B, Biointerfaces
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