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https://www.readbyqxmd.com/read/30340627/the-therapeutic-potential-of-attentional-bias-modification-training-for-insomnia-study-protocol-for-a-randomised-controlled-trial
#1
Umair Akram, Bronwyn Milkins, Antonia Ypsilanti, John Reidy, Lambros Lazuras, Jodie Stevenson, Lies Notebaert, Nicola L Barclay
BACKGROUND: The efficacy of attentional bias modification (ABM) as a treatment for anxiety and depression has been extensively studied with promising results. Despite some evidence of sleep-related attentional biases in insomnia, only a small number of studies, yielding mixed results, have examined the application of ABM in insomnia. This study specifically aims to determine whether ABM can reduce (i) the presence of an attentional bias for sleep-related threatening words; (ii) insomnia symptom severity; (iii) sleep onset latency; and (iv) pre-sleep cognitive arousal amongst individuals with insomnia compared to a non-treatment control group of individuals with insomnia...
October 19, 2018: Trials
https://www.readbyqxmd.com/read/30329199/efficacy-and-safety-of-a-triple-active-sore-throat-lozenge-in-the-treatment-of-patients-with-acute-pharyngitis-results-of-a-multi-centre-randomised-placebo-controlled-double-blind-parallel-group-trial-doripha
#2
Jürgen Palm, Katharina Fuchs, Holger Stammer, Anne Schumacher-Stimpfl, Jens Milde
OBJECTIVE: The aim of this multi-centre, randomised, double-blind, placebo-controlled trial was to compare the efficacy and safety of the fixed combination of 0.5 mg tyrothricin, 1.0 mg benzalkonium chloride, and 1.5 mg benzocaine (study drug marketed as Dorithricin® ) in repeat dosing for 3 days to match placebo lozenges in the treatment of acute pharyngitis in adults. METHODS: Patients (pts, aged ≥18 years) with acute pharyngitis, ie, non-streptococcal sore throat and moderate-to-severe pain (intensity NRS ≥ 7; VAS ≥ 50) were assigned to study drug (n = 160) or matching placebo (n = 161)...
October 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/30322470/-metabolic-control-or-reduction-of-vascular-risk-with-current-treatments-what-is-the-priority
#3
Margarita Alonso Fernández
In patients with type 2 diabetes, tight glycemic control prevents or delays the develop-ment of microvascular complications. In contrast, there is continued debate on the effect of macrovascular complications and the role of early glycaemic control on the ensuing cardiovascular disease. Although large randomised clinical trials have not shown a clearly beneficial effect of intensive control in the short term, subsequent follow-up studies of participants in these trials suggest a favourable cardiovascular effect in the long term...
June 2018: Semergen
https://www.readbyqxmd.com/read/30320251/c-3-and-c-4-substituted-bicyclic-coumarin-sulfamates-as-potent-steroid-sulfatase-inhibitors
#4
Dharshini Ganeshapillai, L W Lawrence Woo, Mark P Thomas, Atul Purohit, Barry V L Potter
Synthetic routes to potent bicyclic nonsteroidal sulfamate-based active-site-directed inhibitors of the enzyme steroid sulfatase (STS), an emerging target in the treatment of postmenopausal hormone-dependent diseases, including breast cancer, are described. Sulfamate analogs 9 - 27 and 28 - 46 of the core in vivo active two-ring coumarin template, modified at the 4- and 3-positions, respectively, were synthesized to expand structure-activity relationships. α-Alkylacetoacetates were used to synthesize coumarin sulfamate derivatives with 3-position modifications, and the bicyclic ring of other parent coumarins was primarily constructed via the Pechmann synthesis of hydroxyl coumarins...
September 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/30320056/recent-progress-in-fused-ring-based-nonfullerene-acceptors-for-polymer-solar-cells
#5
REVIEW
Chaohua Cui
The progress of bulk-heterojunction (BHJ) polymer solar cells (PSCs) is closely related to the innovation of photoactive materials (donor and acceptor materials), interface engineering, and device optimization. Especially, the development of the photoactive materials dominates the research filed in the past decades. Photoactive materials are basically classified as p-type organic semiconductor donor (D) and an n-type organic semiconductor acceptor (A). In the past two decades, fullerene derivatives are the dominant acceptors for high efficiency PSCs...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/30319820/heart-rate-variability-and-cardiovascular-reflex-tests-for-assessment-of-autonomic-functions-in-preeclampsia
#6
Meenakshi Chaswal, Raj Kapoor, Achla Batra, Savita Verma, Bhupendra S Yadav
Alterations in the autonomic cardiovascular control have been implicated to play an important etiologic role in preeclampsia. The present study was designed to evaluate autonomic functions in preeclamptic pregnant women and compare the values with normotensive pregnant and healthy nonpregnant controls. Assessment of autonomic functions was done by cardiovascular reflex tests and by analysis of heart rate variability (HRV). Cardiovascular reflex tests included deep breathing test (DBT) and lying to standing test (LST)...
2018: International Journal of Hypertension
https://www.readbyqxmd.com/read/30319806/different-classical-hydrogen-bonding-patterns-in-three-salicylaldoxime-derivatives-2-ho-4-x-c-6-h-3-c-noh-x-me-oh-and-meo
#7
Ligia R Gomes, Marcus V N de Souza, Cristiane F Da Costa, James L Wardell, John Nicolson Low
The crystal structures of three salicyaldoxime compounds, namely 2-hy-droxy-4-methyl-benzaldehyde oxime, C8 H9 NO2 , 1 , 2,4-di-hydroxy-benzaldehyde oxime, C7 H7 NO3 , 2 , and 2-hy-droxy-4-meth-oxy-benzaldehyde oxime, C8 H9 NO3 , 3 , are discussed. In each compound, the hydroxyl groups are essentially coplanar with their attached phenyl group. The inter-planar angles between the C=N-O moieties of the oxime unit and their attached phenyl rings are 0.08 (9), 1.08 (15) and 6.65 (15)° in 1 , 2 and 3 , respectively...
October 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/30315718/the-p-orbital-delocalization-of-main-group-metal-boosting-co2-electroreduction
#8
Sisi He, Fenglou Ni, Yujin Ji, Lie Wang, Yunzhou Wen, Haipeng Bai, Gejun Liu, Ye Zhang, Youyong Li, Bo Zhang, Huisheng Peng
Electrochemical reduction of CO2 to valuable chemical products is a promising strategy to store intermittent renewable energy and mitigate net greenhouse gas emissions. Among CO2 reduction products, formate has a high product value per electron, and can potentially be used in fuel cells, hydrogen storage, and pharmaceuticals synthesis. However, electrocatalysts for formate production have yet to exhibit the combination of high current density and high power conversion efficiency required for practical applications...
October 13, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30314281/fatty-fish-intake-and-the-effect-on-mental-health-and-sleep-in-preschool-children-in-fins-kids-a-randomized-controlled-trial
#9
Mari Hysing, Ingrid Kvestad, Marian Kjellevold, Lisa Kolden Midtbø, Ingvild Eide Graff, Øyvind Lie, Hallvard Hurum, Kjell Morten Stormark, Jannike Øyen
Mental health and sleep problems are prevalent in children during preschool years. The aim of the current study was to investigate if increased intake of fatty fish compared with meat improves mental health and sleep in four- to six-year-old children. The children ( n = 232) in the two-armed randomized controlled trial, Fish Intervention Studies-KIDS (FINS-KIDS), were randomly assigned to lunch meals with fatty fish (herring/mackerel) or meat (chicken/lamb/beef) three times a week for 16 weeks. The fish and meat were weighed before and after the meals to record the exact consumption in grams (dietary compliance)...
October 11, 2018: Nutrients
https://www.readbyqxmd.com/read/30313820/a-new-distinctive-species-of-barydesmus-diplopoda-polydesmida-platyrhacidae-from-ecuador-with-an-annotated-bibliographical-checklist-of-the-american-platyrhacidae
#10
Ernesto Recuero, Alberto SÁnchez-Vialas
Currently with 85 named species, the family Platyrhacidae in America is still poorly studied, particularly regarding Barydesmus Cook, 1896, the most diversified among the American genera. The center of diversification of Barydesmus lies in the northern third of the Andes Mountains, a megadiverse region where surely more species of these large, conspicuous diplopods await description. Here we present a new species, Barydesmus nangaritza sp. nov., easily diagnosable by the shape of the paranota, unique among the American Platyrhacidae...
September 18, 2018: Zootaxa
https://www.readbyqxmd.com/read/30313696/comparative-studies-on-reproductive-traits-of-natural-populations-of-eisenia-andrei-bouch%C3%A3-1972-from-zagros-mountain-iran-annelida-oligochaeta
#11
Robabeh Latif, Masoumeh Malek, Atabak Roohi Aminjan, Nasim Nadimoghadam, Omid Mirshamsi, Hassan Mirmonsef, Elham Hosseini
Comparative studies were carried out on growth and reproduction patterns of eight populations of Eisenia andrei (Bouché, 1972) from different parts of western Iran along the Zagros Mountains, considered to lie within the natural range of this species. Parameters were gain in body weight, number of cocoon production, hatching success, number of hatchlings, hatchlings growth and survival. There were significant differences in mean numbers of viable cocoons, incubation time, reproductive rate, growth rate and final weight between different populations...
October 4, 2018: Zootaxa
https://www.readbyqxmd.com/read/30308396/theoretical-investigation-on-the-low-lying-electronic-states-of-beryllium-antimonide
#12
Ning Wang, Ming-Jie Wan, Chuan-Zhao Zhang, Yuan-Yuan Jin, Wei-Bin Zhang, Shan-Jun Chen, Song Li
The Λ-S electronic states with respect to the lowest four dissociation limits of BeSb are investigated theoretically on the icMRCI + Q level employing basis set of quintuple-ζ quality. The geometrical parameters, potential energy curves, vibrational energy levels, spectroscopic constants for the twelve Λ - S states are obtained, analyzed and compared with those of the Beryllium-VA group diatomic family species where data are available. The permanent dipole moments, transition dipole moments, Einstein emission coefficients, radiative lifetimes and Franck-Condon factors for interested Λ - S states are also derived...
October 3, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30306356/electron-microscopic-study-of-golgi-impregnated-and-gold-toned-neurons-and-fibers-in-the-claustrum-of-the-cat
#13
Dimka Hinova-Palova, Alexandar Iliev, Lawrence Edelstein, Boycho Landzhov, Georgi Kotov, Adrian Paloff
The claustrum is a subcortical nucleus found in the telencephalon of all placental mammals. It is a symmetrical, thin and irregular sheet of grey matter which lies between the inner surface of the insular cortex and the outer surface of the putamen. The claustrum has extensive connections with the visual, auditory, somatosensory and motor regions of the cortex, as well as with subcortical and allocortical regions. The aim of this study was to provide a detailed description of the morphology of different types of Golgi-impregnated and gold-toned neurons and fibers in the dorsal claustrum of the cat employing the combined Golgi-electron microscope Fairén method...
October 10, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/30305669/lying-down-frequency-as-a-discomfort-index-in-heat-stressed-holstein-bull-calves
#14
Levente Kovács, Fruzsina L Kézér, Mikolt Bakony, Viktor Jurkovich, Ottó Szenci
Changes in lying behaviour in response to extreme ambient temperatures have not been examined in dairy calves so far. In this study, lying time, and frequency of lying down were investigated in shaded (n = 8) and non-shaded (n = 8) Holstein bull calves during a 5-d period [temperature, average/max (°C); Day 1 (control, all calves shaded): 22.9/29.4, Day 2 (heat stress day): 28.3/38.8, Day 3: 26.2/33.5, Day 4: 23.7/28.7, and Day 5: 21.2/24.7]. The thermal environment around the calves was characterized by the temperature-humidity index (THI)...
October 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30305149/adjuvant-transcatheter-arterial-chemoembolization-after-curative-resection-for-hepatocellular-carcinoma-patients-with-solitary-tumor-and-microvascular-invasion-a-randomized-clinical-trial-of-efficacy-and-safety
#15
Wei Wei, Pei-En Jian, Shao-Hua Li, Zhi-Xing Guo, Yong-Fa Zhang, Yi-Hong Ling, Xiao-Jun Lin, Li Xu, Ming Shi, Lie Zheng, Min-Shan Chen, Rong-Ping Guo
BACKGROUND: The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma (HCC) patients with solitary tumor and microvascular invasion (MVI) is controversial. This trial evaluated the efficacy and safety of adjuvant transcatheter arterial chemoembolization (TACE) after hepatectomy versus hepatectomy alone in HCC patients with a solitary tumor ≥ 5 cm and MVI. METHODS: In this randomized, open-labeled, phase III trial, HCC patients with a solitary tumor ≥ 5 cm and MVI were randomly assigned (1:1) to receive either 1-2 cycles of adjuvant TACE after hepatectomy (Hepatectomy-TACE) or hepatectomy alone (Hepatectomy Alone)...
October 10, 2018: Cancer communications
https://www.readbyqxmd.com/read/30305051/the-effect-of-body-position-on-pulmonary-function-a-systematic-review
#16
Shikma Katz, Nissim Arish, Ariel Rokach, Yacov Zaltzman, Esther-Lee Marcus
BACKGROUND: Pulmonary function tests (PFTs) are routinely performed in the upright position due to measurement devices and patient comfort. This systematic review investigated the influence of body position on lung function in healthy persons and specific patient groups. METHODS: A search to identify English-language papers published from 1/1998-12/2017 was conducted using MEDLINE and Google Scholar with key words: body position, lung function, lung mechanics, lung volume, position change, positioning, posture, pulmonary function testing, sitting, standing, supine, ventilation, and ventilatory change...
October 11, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/30301555/intralesional-macular-atrophy-in-anti-vascular-endothelial-growth-factor-therapy-for-age-related-macular-degeneration-in-the-ivan-trial
#17
Clare Bailey, Lauren J Scott, Chris A Rogers, Barnaby C Reeves, Barbra Hamill, Tunde Peto, Usha Chakravarthy, Simon P Harding
PURPOSE: To report on the development and progression of macular atrophy (MA) and its relationship with morphologic and functional measures in study and fellow eyes in the Inhibition of vascular endothelial growth factor (VEGF) in Age-related Choroidal Neovascularisation trial. DESIGN: Reading center analysis of data from a randomized controlled trial. PARTICIPANTS: Participants with previously untreated neovascular age-related macular degeneration (nAMD) in the study eye...
October 6, 2018: Ophthalmology
https://www.readbyqxmd.com/read/30296541/temporary-removal-future-considerations-for-clinical-dermatology-in-the-setting-of-21-st-century-american-policy-reform-corporatization-and-the-rise-of-private-equity-in-dermatology
#18
Sailesh Konda, Joseph Francis, Kiran Motaparthi, Jane M Grant-Kels
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
October 5, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/30295685/mmp%C3%A2-3-deficiency-does-not-influence-the-length-and-number-of-ca1-dendrites-of-hippocampus-of-adult-mice
#19
Daria Nowak, Lies De Groef, Lieve Moons, Jerzy W Mozrzymas
Over the past two decades, metalloproteinases (MMPs), including MMP‑2, MMP‑3, and MMP‑9, have been implicated as important players in mechanisms underlying various forms of neuroplasticity. In particular, MMP‑3 was found to be involved in both cognitive functions and in plasticity phenomena, but the underlying molecular mechanisms remain largely elusive. In general, it is believed that functional plasticity of neurons is associated with morphological alterations. Interestingly, MMP‑9, in addition to playing a key role in synaptic plasticity, was found to affect plasticity‑related spine morphology changes...
2018: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/30294568/an-observational-prospective-study-to-evaluate-the-preoperative-risk-factors-of-new-onset-diabetes-mellitus-after-renal-transplantation-in-a-tertiary-care-centre-in-eastern-india
#20
Santosh Kumar, Debmalya Sanyal, Pratik Das, Kingshuk Bhattacharjee, Rohit Rungta
Objectives: This study aimed to determine the pre-transplant risk factors as independent predictors on the new-onset of diabetes mellitus after renal transplants (NODATs). Materials and Methods: A single-centred prospective real-world observational study of 100 subjects who underwent renal transplantation over a period of 2 years. All known patients with diabetes were excluded from the study. NODAT was defined according to the American Diabetes Association definition...
September 2018: Indian Journal of Endocrinology and Metabolism
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