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Chen Dong, Sudip Paudel, Nana Y Amoh, Margaret S Saha
Transient receptor potential (TRP) cation channel genes code for an extensive family of conserved proteins responsible for a variety of physiological processes, including sensory perception, ion homeostasis, and chemical signal transduction. The TRP superfamily consists of seven subgroups, one of which is the transient receptor potential vanilloid (trpv) channel family. While trpv channels are relatively well studied in adult vertebrate organisms given their role in functions such as nociception, thermoregulation, and osmotic regulation in mature tissues and organ systems, relatively little is known regarding their function during embryonic development...
October 13, 2018: Gene Expression Patterns: GEP
Sabuj Kanti Das, Snehasis Mishra, Krishnendu Manna, Utpal Kayal, Supratim Mahapatra, Krishna Das Saha, Sasanka Dalapati, G P Das, Amany A Mostafa, Asim Bhaumik
Correction for 'A new triazine based π-conjugated mesoporous 2D covalent organic framework: its in vitro anticancer activities' by Sabuj Kanti Das et al., Chem. Commun., 2018, 54, 11475-11478.
October 16, 2018: Chemical Communications: Chem Comm
Nicolas Veland, Yue Lu, Swanand Hardikar, Sally Gaddis, Yang Zeng, Bigang Liu, Marcos R Estecio, Yoko Takata, Kevin Lin, Mary W Tomida, Jianjun Shen, Debapriya Saha, Humaira Gowher, Hongbo Zhao, Taiping Chen
DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA methyltransferase activity but regulates de novo DNA methylation. While biochemical studies show that DNMT3L is capable of interacting with both DNMT3A and DNMT3B and stimulating their enzymatic activities, genetic evidence suggests that DNMT3L is essential for DNMT3A-mediated de novo methylation in germ cells but is dispensable for de novo methylation during embryogenesis, which is mainly mediated by DNMT3B. How DNMT3L regulates DNA methylation and what determines its functional specificity are not well understood...
October 13, 2018: Nucleic Acids Research
Sandeepta Saha, Niladri Biswas, Ashok Sasmal, Carlos J Gómez-García, Eugenio Garribba, Antonio Bauza, Antonio Frontera, Guillaume Pilet, Georgina M Rosair, Samiran Mitra, Chirantan Roy Choudhury
Two new copper(ii) polymeric complexes, {[Cu(HPymat)(H2O)](NO3)}n (1) and [Cu2(Pymat)2(H2O)3]n (2), have been synthesized using the Schiff base ligand H2Pymat [H2Pymat = (E)-2-(1-(pyridin-2-yl)-methyleneamino)terephthalic acid]. Complex 1 is a cationic 1D polymer, whereas complex 2 is a two dimensional polymer. Both complexes were crystallographically, spectroscopically and magnetically characterized. Theoretical studies were performed and the catecholase activity of the complexes was also examined. Complex 1 is a ferromagnetically coupled complex with J = 2...
October 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Sumit Kumar, Sourav Taru Saha, Liang Gu, Gabriella Palma, Shanen Perumal, Ashona Singh-Pillay, Parvesh Singh, Amit Anand, Mandeep Kaur, Vipan Kumar
1 H -1,2,3-Triazole tethered imidazole-isatin and imidazole-isatin-thiosemicarbazone conjugates were synthesized and evaluated against MCF-7 and MDA-MB-231 cell lines. Antiproliferative activities of the synthesized conjugates revealed an optimum combination of longer alkyl chain length as spacer and a halogen-substituent on the isatin ring as a pre-requisite for good activity. The compound 6g with an optimum combination of chloro-substituent at C-5 position of isatin ring and a butyl chain length proved to be most active and noncytotoxic with IC50s of 54...
September 30, 2018: ACS Omega
Mahesh Parit, Partha Saha, Virginia A Davis, Zhihua Jiang
In the context of valorization of lignin produced from the pulp and paper industries, biodegradable UV-protection films were prepared using lignin and cellulose nanocrystals (CNCs). Initially, CNC films were optimized for improving their transparency by studying the effect of various sodium hydroxide (NaOH) concentrations. Maximum (%) transmittance of CNC film was obtained for NaOH addition between 3 and 4 wt %. The optimized CNC suspensions were used for incorporating alkaline lignin (AL) and softwood kraft lignin (SKL) in various concentrations (1-10 wt %)...
September 30, 2018: ACS Omega
Ashirbani Saha, Xiaozhi Yu, Dushyant Sahoo, Maciej A Mazurowski
Purpose: To assess the impact of varying magnetic resonance imaging (MRI) scanner parameters on the extraction of algorithmic features in breast MRI radiomics studies. Methods: In this retrospective study, breast imaging data for 272 patients were analyzed with magnetic resonance (MR) images. From the MR images, we assembled and implemented 529 algorithmic features of breast tumors and fibrograndular tissue (FGT). We divided the features into 10 groups based on the type of data used for the feature extraction and the nature of the extracted information...
November 30, 2017: Expert Systems with Applications
Romi Dasgupta, Indraneel Saha, Prajna Paramita Ray, Aniruddha Maity, Debajoyti Pradhan, Hari Prasad Sarkar, B R Maiti
Arecoline has biomedical importance, but it has untoward side effects on endocrine functions. The aim is to investigate its role on adrenal activity under thermal stress by ultrastructural and hormonal parameters in mice. Cold (4 °C) or heat (37 °C) stress, or arecoline (10 mg/kg body wt), each for 7 days in cold or heat stress stimulated adrenocortical activity ultrastructurally with an elevation of corticosterone level. Adrenomedullary activity was suppressed in cold stress with depletion of catecholamine levels...
October 13, 2018: Archives of Physiology and Biochemistry
Mrityunjay Tyagi, Biswanath Maity, Bhaskar Saha, Ajay Kumar Bauri, Mahesh Subramanian, Subrata Chattopadhyay, Birija Sankar Patro
The spice-derived phenolic, malabaricone B (mal B) showed selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, mal B showed maximum cytotoxicity to the A549 cells (IC50 = 8.1 ± 1.0 μM), which was significantly better than that of curcumin (IC50 = 26.7 ± 3.1 μM). Further morphological studies by phase contrast microscopy and a clonogenic assay of the A549 cells revealed that mal B treatment increased the number of shrinking cells and also abolished the clonal proliferation of the cells...
October 15, 2018: Food & Function
Sunil Kumar Dubey, Gautam Singhvi, Kowthavarapu Venkata Krishna, Tejas Agnihotri, Ranendra Narayan Saha, Gaurav Gupta
Neurodegenerative disorders are one of the most debilitating, chronic, and often irreversible disorders of the brain and have gained a widespread attention of researchers. Since current therapeutics seem to be inadequate treatment of these disorders, scientists are exploring their options with herbal drugs. This review discusses herbal constituents with the potential to treat neurological disorders. These herbal drugs, when combined with a novel delivery system, provide added advantages to nanocarrier systems...
2018: Journal of Environmental Pathology, Toxicology and Oncology
Rathin Maity, Santanu Majumder, Amit Roychowdhury, Subrata Saha
The goal of this finite element study is to reduce the stress shielding effect in tibial fracture fixation. Five different plates with modified geometry have been modeled. The fracture gap is assumed to be filled with callus, which is new born healing tissue. The effect of different plate modifications in four different healing stages has been compared to the nonmodified plate. It has been observed that all the modified models have higher callus stress than the nonmodified model, and the best modified plate has reduced the stress shielding effect by 117% for the first healing stage...
2018: Journal of Long-term Effects of Medical Implants
Jayanta Kr Biswas, Sandipan Roy, Santanu Majumder, Santanu Kr Karmakar, Subrata Saha, Amit Roychowdhury
Currently, intervertebral disc prostheses that are designed to restore mobility to a vertebral segment are possible for the lumbar spine. The ball-and-socket joint is a constrained design, wherein the rotational axis of the intervertebral joint is forced to pass through the center of the spherical surfaces that form the joint. One advantage of ball-and-socket joints versus unconstrained designs includes better shear stability, which results in sufficient flexibility. In this study, finite element analyses were performed in preimplanted and implanted (intervertebral disc replacement [IDR]) lumbar spine (L1-S) models to examine range of motion (ROM) and the resulting mechanical responses in the implant and the adjacent bones...
2018: Journal of Long-term Effects of Medical Implants
Freddy Caldera, Elizabeth Ann Misch, Sumona Saha, Arnold Wald, Youqi Zhang, Jeffrey Hubers, Bryant Megna, Dana Ley, Mark Reichelderfer, Mary S Hayney
BACKGROUND: The Advisory Committee on Immunization Practices (ACIP) recommends using the immunization record and not serologic testing to determine immunity against measles and rubella in the general population, due to potential false negatives. However, it is unknown whether the immune response is less durable among patients who are immunosuppressed. AIMS: The primary aim of this study was to evaluate sustained vaccine-induced measles, mumps, and rubella (MMR) antibody concentrations in immunosuppressed patients with inflammatory bowel disease (IBD)...
October 13, 2018: Digestive Diseases and Sciences
Jay Prakash, Sunita Yadav, Gundappa Saha, Adarsh Kumar Chiranjivi, Suresh Kumar, Santanu Sasidharan, Prakash Saudagar, Vikash Kumar Dubey
Trypanothione based redox metabolism is unique to the Trypanosomatida family. Despite extensive studies on redox metabolism of Leishmania parasites, a prominent question of why Leishmania adopt this unique redox pathway remains elusive. We have episomally expressed human glutathione reductase (HuGR) in Leishmania donovani (LdGR+) and investigated its effect. LdGR+ strain has slower growth compared to the wild type (Ld) indicating decreased survival ability of the strain. Further, LdGR+ strain showed enhanced accumulation of intracellular reactive oxygen species (ROS) and more sensitivity to the anti-leishmanial drug, Miltefosine, inferring increased stress level...
October 11, 2018: International Journal of Biological Macromolecules
Areen Sen, Ratul Saha, Kuppuswamy Sivakumar, Punyasloke Bhadury
Modern benthic foraminiferal assemblages are instrumental in providing information regarding changes in relative sea level as well as prevailing environmental conditions in marine environments. Marginal marine environments are coastal environments that are in most cases characterized by high influx of terrestrially originated nutrients. Inventorizing of modern benthic foraminiferal assemblages from such habitats can act as biotic indicators of water quality variations along with any changes in relative sea level...
June 27, 2018: Zootaxa
Kumar K Vineeth, U K Radhakrishna, R D Godwin, Saha Anwesha, K Patil Rajashekhar, N A Aravind
A new species of microhylid frog Microhyla kodial sp. nov. from the west coast of India is described in this paper. It is distinct from all described species of Microhyla occurring in South and Southeast Asia as revealed by a combination of morphological, molecular and acoustic characters. The new species is characterized by absence of lateral body stripe, tuberculated dorsal skin surface, absence of webbing between fingers, presence of basal webbing between toes and absence of dorsal marginal groove on finger and toe disc...
May 16, 2018: Zootaxa
Sandra E Ghayad, Ghina Rammal, Omar Sarkis, Hussein Basma, Farah Ghamloush, Assil Fahs, Mia Karam, Mohamad Harajli, Wissam Rabeh, Joe E Mouawad, Hassan Zalzali, Raya Saab
Rhabdomyosarcoma (RMS) is an aggressive childhood sarcoma with two distinct subtypes, embryonal (ERMS) and alveolar (ARMS) histologies. More effective treatment is needed to improve outcomes, beyond conventional cytotoxic chemotherapy. The pan-histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), has shown promising efficacy in limited preclinical studies. We used a panel of human ERMS and ARMS cell lines and xenografts to evaluate the effects of SAHA as a therapeutic agent in both RMS subtypes...
October 11, 2018: Cancer Biology & Therapy
Caitlin Barkume, Kashmira Date, Samir K Saha, Farah Naz Qamar, Dipika Sur, Jason R Andrews, Stephen P Luby, M Imran Khan, Alex Freeman, Mohammad Tahir Yousafzai, Denise Garrett
Objective: The objective of Phase I of the Surveillance for Enteric Fever in Asia Project (SEAP), a multiphase surveillance study characterizing the burden of disease in South Asia, was to inform data collection for prospective surveillance and to capture clinical aspects of disease. Methods: Through a retrospective record review conducted at hospitals in Bangladesh, India, Nepal, and Pakistan, we examined laboratory and clinical records to assess the culture positivity rate for Salmonella Typhi and Salmonella Paratyphi, age and sex distribution, and antimicrobial susceptability in each country...
October 10, 2018: Journal of Infectious Diseases
Issan Zhang, Maja Beus, Ursula Stochaj, Phuong Uyen Le, Branka Zorc, Zrinka Rajić, Kevin Petrecca, Dusica Maysinger
Glioblastoma multiforme is one of the most aggressive brain tumors and current therapies with temozolomide or suberoylanilide hydroxamic acid (SAHA, vorinostat) show considerable limitations. SAHA is a histone deacetylase (HDAC) inhibitor that can cause undesirable side effects due to the lack of selectivity. We show here properties of a novel hybrid molecule, sahaquine, which selectively inhibits cytoplasmic HDAC6 at nanomolar concentrations without markedly suppressing class I HDACs. Inhibition of HDAC6 leads to significant α-tubulin acetylation, thereby impairing cytoskeletal organization in glioblastoma cells...
2018: Cell Death Discovery
T Hanley, S Papa, M Saha
Immunotherapy is now being routinely used in the management of many cancers. It is therefore vital that all clinicians are aware of the diverse array of cutaneous manifestations that can result from their use, which can vary from mild to life threatening.
October 2018: JRSM Open
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