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Quan Wu, Li Ke, Chi Wang, Pingsheng Fan, Zhiwei Wu, Xiaoling Xu
Lysine 2-hydroxyisobutyrylation is a newly discovered protein acylation and was reported to share acyltransferases and deacylases with the widely studied lysine acetylation. The well-known acetyltransferase Tip60 and histone deacetylases HDAC 2 and HDAC 3 were discovered to be "writer" and "eraser" of this new PTM on histones. However, the acyltransferases and deacylases for non-histone proteins are still unclear. In this work, lysine 2-hydroxyisobutyrylome on both histones and non-histone proteins upon SAHA treatment were intensively studied and 8,765 lysine 2-hydroxyisobutyrylation sites on 2,484 proteins were identified in A549 cells...
August 15, 2018: Journal of Proteome Research
Harshita Krishnatreyya, Hemanga Hazarika, Achintya Saha, Pronobesh Chattopadhyay
Eye irritation assessment is compulsory to anticipate health risks in military personnel exposed to riot control agents such as capsaicin, the principal constituent of oleoresin capsicum, or pepper sprays. The present work investigates certain fundamental yet unaddressed pharmacological manifestations on ocular exposure to capsaicin. Ocular pharmacology of capsaicin was studied using acute eye irritation (AEI), bovine corneal opacity and permeability (BCOP) assay, corneal fluorescein staining and indirect ophthalmoscopy studies, transcorneal permeation, Schirmer tear secretion test, nerve conduction velocity study and enzyme-linked immunosorbent assay (ELISA)...
August 14, 2018: Scientific Reports
Cameron McDonald-Hyman, James T Muller, Michael Loschi, Govindarajan Thangavelu, Asim Saha, Sudha Kumari, Dawn K Reichenbach, Michelle J Smith, Guoan Zhang, Brent H Koehn, Jiqiang Lin, Jason S Mitchell, Brian T Fife, Angela Panoskaltsis-Mortari, Colby J Feser, Andrew Kemal Kirchmeier, Mark J Osborn, Keli L Hippen, Ameeta Kelekar, Jonathan S Serody, Laurence A Turka, David H Munn, Hongbo Chi, Thomas A Neubert, Michael L Dustin, Bruce R Blazar
Regulatory T-cells (Treg) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control Treg function may allow for the augmentation of therapeutic efficacy. In contrast to activated conventional T-cells, where protein kinase C-θ (PKC-θ) localizes to the contact-point between T-cells and antigen-presenting cells, in human and mouse Treg, PKC-θ localizes to the opposite end of the cell in the distal pole complex (DPC)...
August 14, 2018: Journal of Clinical Investigation
Karamjyoti Panigrahi, Subhajit Saha, Sumanta Sain, Rituparna Chatterjee, Antika Das, Uttam Kumar Ghorai, Nirmalya Sankar Das, Kalyan Kumar Chattopadhyay
Feeble white emission with a low Colour Rendering Index (CRI) has become the principal gridlock for the extensive commercialization of phosphor converted white LEDs (pc-WLEDs). Fusion of red, green and blue emitting rare-earth (RE) ions in a suitable host can overcome these drawbacks but the energy migration between multiple RE ions at single excitation wavelength defines the key standpoint in designing such white light emitting phosphors. Apart from the abovementioned obstacles, recently traditional optical temperature sensors based on RE ions have faced difficulties due to their low relative sensitivity and large detection error...
August 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Mukta Singh, Ratan Kumar Saha, Himadri Saha, Janmejay Parhi
This study evaluated the effect of sublethal doses of antifungal drug miconazole nitrate (MCZ) on immunological responses and its role as a prophylactic drug against S. parasitica in Labeo rohita fingerlings. Fish were fed with sublethal doses of MCZ, that is, T1-6.30 mgMCZ kgBW-1 , T2-12.61 mgMCZ kgBW-1 and T3-25.22 mgMCZ kgBW-1 , and sampling was done at different time intervals for 240 hr. Immunological parameters viz. lysozyme activity, oxygen radical production and plasma antiprotease activity showed significant enhancement (p < 0...
August 13, 2018: Journal of Fish Diseases
Koel Saha, Poulami Dwibedi, Ankita Ghosh, Jaya Sikder, Sudip Chakraborty, Stefano Curcio
The primary focus of this work was to recover lignin and investigate the structural changes in sugarcane bagasse after pretreatment with ionic liquid 1-ethyl-3-methylimidazolium acetate ([EMIM]oAc). 90% lignin recovery was achieved while bagasse was treated with [EMIM]oAc at 140 °C, 120 min reaction time and 1:20 bagasse to the ionic liquid ratio (w/w). The impact of ionic liquid pretreatment on bagasse was confirmed by qualitative analysis of untreated and pretreated bagasse. Scanning electron microscopy analysis exhibited the porous and irregular structure of bagasse after pretreatment...
August 2018: 3 Biotech
Bithika Saha, Rocco Longo, Peter Torley, Anthony Saliba, Leigh Schmidtke
The important sampling parameters of a headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) procedure such as the extraction temperature, extraction time, and sample volume were optimized to quantify 23 important impact odorants in reduced alcohol red and white wines. A three-factor design of Box-Behnken experiments was used to determine the optimized sampling conditions for each analyte, and a global optimized condition at every ethanol concentration of interest determined using a desirability function that accounts for a low signal response for compounds...
August 10, 2018: Foods (Basel, Switzerland)
Chang You, Bertha J Vandegrift, Huaibo Zhang, Amy W Lasek, Subhash C Pandey, Mark S Brodie
BACKGROUND: The ventral tegmental area (VTA) is important for alcohol-related reward and reinforcement. Mouse VTA neurons are hyposensitive to γ-aminobutyric acid (GABA) during ethanol withdrawal, and GABA responsiveness is normalized by in vitro treatment with histone deacetylase inhibitors (HDACi). The present study examined the effect of a systemically-administered HDACi, suberanilohydroxamic acid (SAHA) on GABA sensitivity and related molecular changes in VTA neurons during withdrawal after chronic ethanol intake in rats...
August 13, 2018: Alcoholism, Clinical and Experimental Research
Niladri Biswas, Sandeepta Saha, Sumit Khanra, Arnab Sarkar, Deba Prasad Mandal, Shamee Bhattacharjee, Ankur Chaudhuri, Sibani Chakraborty, Chirantan Roy Choudhury
Two novel copper (II) substituted thiosemicarbazone Schiff base complexes [Cu(L1 )(µ-SCN)]n (NO3 )2 (1) and [Cu2 (µ-SCN)(SCN)(L2 )2 ](NO3 ) (2) have been synthesized by condensing substituted thiosemicarbazides like 4-methyl-3-thiosemicarbazide or 4-ethyl-3-thiosemicarbazide with 2-acetylpyridine. Both the metal complexes 1 and 2 are characterized by different spectroscopic techniques like IR, UV-Vis, ESR spectroscopy followed by elemental analysis, cyclic voltammetric measurement and single crystal X-ray structure analysis...
August 13, 2018: Journal of Biomolecular Structure & Dynamics
Puja Kumari, Neha Singh, Lekha Saha
OBJECTIVES: Dimethyl sulfoxide (DMSO) is commonly used as a vehicle for many hydrophobic drugs. This study aimed at evaluating the effect of low dose of DMSO (0.1%) on Pentylenetetrazole(PTZ) induced neuronal damage in rats. MATERIALS AND METHODS: Young male Wistar rats (n = 32) were divided into four groups as follows: saline control group, DMSO control group, PTZ group (35 mg/kg), and combination group (DMSO + PTZ). Animals were observed for seizure score, latency to develop kindling, percentage of animals kindled, and histopathological score of hippocampus...
March 2018: Indian Journal of Pharmacology
Bobbity Deepthi, Samridhi Goyal, Rachita Singh Dhull, Preeti Rai, Abhijeet Saha
A seven-year-old boy with nephrotic syndrome presented with a frequent rash along with relapse of nephrotic syndrome. Clinical and histological features were suggestive of pityriasis lichenoides et varioliformis acuta (PLEVA). Treatment of the condition with doxycycline led to the cure of the lesions as well as the relapses.
August 12, 2018: Tropical Doctor
Samir K Saha, Anatoli Kiotsekoglou, Aasha S Gopal
This viewpoint with two illustrated case summaries of biventricular and biatrial mechanical function/dysfunction emphasizes the importance of continued research in deformation imaging beyond the left ventricle, as there are no Cinderellas in the heart and we just cannot afford to be nonchalant toward the atria, particularly the right atrium.
August 12, 2018: Echocardiography
Md Tarikul Islam, Suprovath Kumar Sarker, Shezote Talukder, Golam Sarower Bhuyan, Asifuzzaman Rahat, Nafisa Nawal Islam, Hasan Mahmud, Mohammad Amir Hossain, A K M Muraduzzaman, Jakia Rahman, Syeda Kashfi Qadri, Mohammod Shahidullah, Mohammad Abdul Mannan, Sarabon Tahura, Manzoor Hussain, Narayan Saha, Shahida Akhter, Nazmun Nahar, Firoza Begum, Tahmina Shirin, Sharif Akhteruzzaman, Syed Saleheen Qadri, Firdausi Qadri, Kaiissar Mannoor
BACKGROUND: Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon exposure to oxidative stress induced by certain foods such as fava beans, drugs or infections. Although hemizygous males and homozygous females are easily detected by conventional G6PD enzyme assay method, the heterozygous state could be missed by the conventional methods as the mosaic population of both normal and deficient RBCs circulates in the blood...
August 10, 2018: BMC Genetics
Alex S Huang, Rafaella C Penteado, Sajib K Saha, Jian L Do, Phillip Ngai, Zhihong Hu, Robert N Weinreb
PURPOSE: To evaluate aqueous humor outflow (AHO) in intact eyes of live human subjects during cataract surgery using fluorescein aqueous angiography. METHODS: Aqueous angiography was performed in 8 live human subjects (56 - 86▒y old; 2 men and 6 women). After anesthesia, fluorescein (2%) was introduced into the eye (either alone or after indocyanine green [ICG; 0.4%]) from a sterile, gravity-driven constant-pressure reservoir. Aqueous angiographic images were obtained with a Spectralis HRA+OCT and FLEX module (Heidelberg Engineering)...
August 7, 2018: Journal of Glaucoma
Zareen Sultana, Biswabandhu Bankura, Arup Kumar Pattanayak, Debmalya Sengupta, Mainak Sengupta, Makhan Lal Saha, Chinmay Kumar Panda, Madhusudan Das
Interleukin 1 beta (IL-1β) and Tumor necrosis factor alpha (TNF-α) are key inflammatory cytokines whose polymorphisms have been correlated with increased susceptibility to gastric cancer (GC). Since geographical and racial differences exist in cancer rates, our study was aimed to evaluate the first possible association of polymorphisms in these genes with GC risk in West Bengal, India. Polymorphisms in IL-1β and TNF-α genes were genotyped in 120 GC patients and 135 healthy individuals. Combined effect of the SNPs in both genes with GC risk was determined through allele dosage analysis (ADA) and the survival data were analyzed by Log Rank Test...
August 9, 2018: Environmental and Molecular Mutagenesis
Ji-Cheng Wu, Hua-Mao Jiang, Xiang-Hong Yang, Hua-Chuan Zheng
Neuroblastoma is the most common extracranial solid neuroendocrine cancer and is one of the leading causes of death in children. To improve clinical outcomes and prognosis, discovering new promising drugs and targeted medicine is essential. We found that applying Suberoylanilide hydroxamic acid (SAHA; Vorinostat, a histone deacetylase inhibitor) and MG132 (a proteasome inhibitor) to SH-SY5Y cells synergistically suppressed proliferation, glucose metabolism, migration, and invasion and induced apoptosis and cell cycle arrest...
August 9, 2018: Cancer Medicine
Debiprasad Roy, Koushik Majhi, Maloy Kr Mondal, Swadhin Kr Saha, Subrata Sinha, Pranesh Chowdhury
Allylamine-functionalized silicon quantum dots (ASQDs) of high photostability are synthesized by a robust inverse micelle method to use the material as a fluorescent probe for selective recognition of thiocyanate (a biomarker of a smoker and a nonsmoker). The synthesized ASQDs were characterized by absorption, emission, and Fourier transform infrared spectroscopy. Surface morphology is studied by transmission electron microscopy and dynamic light scattering. The synthesized material exhibits desirable fluorescence behavior with a high quantum yield...
July 31, 2018: ACS Omega
Jayeeta Sarkar, Debraj Saha, Bhaswati Bandyopadhyay, Bibhuti Saha, Runu Chakravarty, Subhasish Kamal Guha
Background: Combination of tenofovir disoproxil fumarate (TDF), lamivudine (3TC) and efavirenz (EFV) is preferred in the treatment of HIV/hepatitis B virus (HBV) coinfection. We postulated that a HBV active nucleoside reverse transcriptase (RT) inhibitor/nucleotide RT inhibitor backbone of adefovir dipivoxil (ADV) +3TC would be as effective as TDF +3TC for the Indian population. Objective: ADV + 3TC could be an alternative option for these HIV/HBV coinfected individuals, preserving the dually active TDF + 3TC as second-line nucleoside backbone following failure of the first-line ART...
April 2018: Indian Journal of Medical Microbiology
Indranil Saha, Kamirul Islam, Bobby Paul, Tapas Kumar Som
Tobacco use causes many diseases irrespective of age and sex. More the addiction, more is the occurrence of morbidity in terms of frequency and severity. This community-based study was conducted to find out any relationship between the morbidity associated with tobacco use and nicotine dependence. In an urban slum - Alamganj, district Burdwan, West Bengal, India, from January to October 2012 among 128 current adult tobacco users using Fagerström test for nicotine dependence (FTND) questionnaire. Tobacco users were maximally suffering from chronic obstructive pulmonary disease (COPD) (27...
2018: Journal of Education and Health Promotion
Indrashis Podder, Abanti Saha, Debabrata Bandyopadhyay
No abstract text is available yet for this article.
July 2018: Indian Journal of Dermatology
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