Second-order Calibration

INTRODUCTION: The use of serial coronary computed tomography angiography (CCTA) allows for the early assessment of coronary plaque progression, a crucial factor in averting major adverse cardiac events (MACEs). Traditionally, serial CCTA is assessed using anatomical landmarks to match baseline and follow-up scans. Recently, a tool has been developed that allows for the automatic quantification of local plaque thickness differences in serial CCTA utilizing plaque contour delineation. The aim of this study was to determine thresholds of plaque thickness differences that define whether there is plaque progression and/or regression...

The use of mathematical models to make predictions about tumor growth and response to treatment has become increasingly prevalent in the clinical setting. The level of complexity within these models ranges broadly, and the calibration of more complex models requires detailed clinical data. This raises questions about the type and quantity of data that should be collected and when, in order to maximize the information gain about the model behavior while still minimizing the total amount of data used and the time until a model can be calibrated accurately...

Socioeconomic resources (SER) calibrate the developing brain to the current context, which can confer or attenuate risk for psychopathology across the lifespan. Recent multivariate work indicates that SER levels powerfully influence intrinsic functional connectivity patterns across the entire brain. Nevertheless, the neurobiological meaning of these widespread alterations remains poorly understood, despite its translational promise for early risk identification, targeted intervention, and policy reform. In the present study, we leverage the resources of graph theory to precisely characterize multivariate and univariate associations between household SER and the functional integration and segregation (i...

Crack disease is one of the most serious and common diseases in road detection. Traditional manual methods for measuring crack detection can no longer meet the needs of road crack detection. In previous work, the authors proposed a crack detection method for asphalt pavements based on an improved YOLOv5s model, which is a better model for detecting various types of cracks in asphalt pavements. However, most of the current research on automatic pavement crack detection is still focused on crack identification and location stages, which contributes little to practical engineering applications...

Bacillus anthracis spores can cause contagious anthrax, so it is significant for the public safety to detect its biomarker dipicolinic acid (DPA). Ratiometric fluorescent probes for DPA have attracted great interest because of the self-calibration effect, but they suffer from the complicated construction of dual-emitting materials. With combining fluorescence and second-order scattering (SOS), Eu-doped Zn-based metal-organic framework (ZIF-8) was here designed as a ratiometric probe for DPA, avoiding the completed construction of dual-emitting materials...

Sensitivity analysis of urban flood model parameters is important for efficient and accurate flood simulation. In order to explore the problems of large sampling parameters and nonlinear correlation between input and output variables, this paper proposed a new correlation analysis approach. The type, strength, and the order of sensitive parameters to the four outputs are analyzed using the proposed approach. The results show that the R values of Manning-N are biggest, its distribution is linear in heat maps, and the Manning-N has a strong linear correlation with Average Depth, Hour of Maximum Flooding, and Time to Peak...

(1) Background: Direct oral anticoagulants (DOACs) require monitoring in some critical clinical situations. The specific tests for DOAC monitoring are not yet available in all labs. The aim of this study was to evaluate if a unique, more widespread heparin-calibrated anti-Xa assay could be suitable to estimate the concentrations of apixaban and rivaroxaban in order to establish an algorithm helping our clinicians in their therapeutic decision for patients treated with DOACs in emergencies. (2) Methods: A first retrospective part allowed us to determine of a conversion factor between the measured DOAC concentration and the deducted anti-Xa heparin activity based on optic density...

BACKGROUND: In the UK, the number of new HIV diagnoses among gay and bisexual men who have sex with men (GBMSM) has decreased substantially. We aimed to understand the contribution of different interventions in reducing HIV incidence so far; to estimate future HIV incidence with continuation of current policies and with further scaling up of current interventions; and to estimate the maximum additional annual cost that should be spent towards these interventions for them to offer value for money...

This work presents the development of a cavity ring-down spectrometer (CRDS) designed for the detection of several molecules relevant for air pollution, including the second overtone of ro-vibration transitions from CO at 1.58 µm and NO at 1.79 µm. A unique feature of this CRDS is the use of custom mirrors with a reflectivity of about 99.99% from 1.52 to 1.80 µm, enabling efficient laser coupling into the cavity while ensuring a minimum detectable absorbance of 1.1 × 10-10 cm-1 within an integration time of about 1...

This work provides a description of the aggregation equilibria of ibuprofen acid in deionized water at temperatures between 20 and 40 °C in the 0.1-20.1 ppm concentration range. For this goal, we have made use of UV-Visible spectroscopy. A calculation algorithm was developed to obtain the aggregate orders and thermodynamic parameters from the experimental absorbance values. Monomeric ibuprofen acid was found to be absent in water solutions. In addition to the dimer, two aggregates formed by 32 and 128 monomeric units were found to co-exist in solution at the highest concentration tested...

The use of retention function and relative conductivity function is essential for the calculation of flow in a variably saturated media using the Richards equation. A widely used mathematical model for this is the Mualem-van Genuchten model which requires the shape parameters α and n. These, however, are difficult to obtain. When data is scarce, α and n are often taken from literature and may deviate largely from actual values. The current study presents a novel mathematical model for the approximation of α and n and for the further estimation of realistic value ranges, which may be used as parameter space e...

Recently, it was found that paracetamol can extend the therapeutic window of l-DOPA treatment for Parkinson's disease [Golding (2019) BJPharm, 4(2), Article 619]. It has been posited that the effect could be due to paracetamol and its metabolite, NAPQI, inhibiting pain signals in the spinal column. In this work, we examine the possibility that the therapeutic effect of the paracetamol for the Parkinson's disease patient may be due to an inhibition of the enzymes that metabolize dopamine and/or l-DOPA, thus effectively extending the lifetime of the l-DOPA treatment...

Online X-ray Fluorescence (XRF) setup was constructed and optimized for analysing the P2 O5 content in phosphate slurry (PS). Serval samples were analysed using two configurations of the setup, one with low and vertical flow and another with high and horizontal flow. The mean absolute error achieved through the first configuration was 0.87% and 0.38% using the second configuration. Reference samples were analyzed using the two configurations to construct the calibration curves. The curves cover a concentration range of P2 O5 from 13...

Herein, we demonstrate the preparation and application of NiCo2 O4 decorated over a g-C3 N4 -based novel nanocomposite (NiCo2 O4 @g-C3 N4 ). The prepared material was well characterized through several physicochemical techniques, including FT-IR, XRD, SEM, and TEM. The electrochemical characterizations via electrochemical impedance spectroscopy show the low electron transfer resistance of NiCo2 O4 @g-C3 N4 owing to the successful incorporation of NiCo2 O4 nanoparticles on the sheets of g-C3 N4 . NiCo2 O4 @g-C3 N4 nanocomposite was employed in the fabrication of a screen-printed carbon electrode-based innovative electrochemical sensing platform and the adsorptive removal of a food dye, i...

Polycyclic aromatic hydrocarbons (PAHs), as a class of organic pollutants that have attracted much attention, are likely to be formed with the production and processing of plastic products, and they may migrate from contaminated plastic products to food, causing the risk of poisoning or cancer. In this study, migration tests were carried out on disposable plastic products for food contact, and a novel strategy that combines excitation-emission matrix (EEM) fluorescence spectroscopy with the advanced second-order calibration method based on the three-direction resection alternating trilinear decomposition (TDR-ATLD) algorithm was used to monitor the migration of three PAHs anthracene (ANT), pyrene (PYR), and phenanthrene (PHE) from the plastic products to food simulants in real-time...


Currently, steady-state visual evoked potentials (SSVEPs)-based brain-computer interfaces (BCIs) have achieved the highest interaction accuracy and speed among all BCI paradigms. However, its decoding efficacy deeply depends on the number of training samples, and the system performance would have a dramatical drop when the training dataset decreased to a small size. To date, no study has been reported to incorporate the unsupervised learning information from testing trails into the construction of supervised classification model, which is a potential way to mitigate the overfitting effect of limited samples...

PURPOSE: An accurate estimation of range uncertainties is essential to exploit the potential of proton therapy. According to Paganetti's study, a value of 2.4% (1.5 standard deviation) is currently recommended for planning robust treatments with Monte Carlo dose engines. This number is based on a dominant contribution from the mean excitation energy of tissues. However, it was recently shown that expressing tissues as a mixture of water and "dry" material in the CT calibration process allowed for a significant reduction of this uncertainty...

As a fruit with high economic value, strawberry has a short ripeness period, and harvesting at an incorrect time will seriously affect the quality of strawberries, thereby reducing economic benefits. Therefore, the timing of its harvesting is very demanding. A fine ripeness recognition can provide more accurate crop information, and guide strawberry harvest management more timely and effectively. This study proposes a fine recognition method for field strawberry ripeness that combines deep learning and image processing...

A simple and low-cost green preparation method was used for BSA capped silver nanoclusters (BSA-Ag NCs) as turn on fluorescent probe for glucose. Non-enzymatic fast glucose detection assay with a widest concentration range was proposed which requires neither nanoclusters (NCs) modification nor complicated enzyme immobilization. The DLS analysis, HRTEM patterns, fluorescence and UV-visible measurement well supported the synthesis product. The advantages of the fabricated glucose sensor based on fluorescence increasing of probe compared to other established optical techniques was inspected and summarized as well...

Surrogate models are frequently used to replace costly engineering simulations. A single surrogate is frequently chosen based on previous experience or by fitting multiple surrogates and selecting one based on mean cross-validation errors. A novel stacking strategy will be presented in this paper. This new strategy results from reinterpreting the model selection process based on the generalization error. For the first time, this problem is proposed to be translated into a well-studied financial problem: portfolio management and optimization...