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JOURNAL ARTICLE
Anu Anand, Rajeev Kumar, Shatrudhan Pandey, S M Mozammil Hasnain, Saurav Goel
This work explores the influence of a pre-engineered notch on the electromagnetic radiation (EMR) parameters in NiTi shape memory alloy (SMA) during tensile tests. The test data showed that the EMR signal fluctuated between oscillatory and exponential, signifying that the specimen's viscosity damping coefficient changes during strain hardening. The EMR parameters, maximum EMR amplitude, and average EMR energy release rate remained constant initially but rose sharply with the plastic zone radius with progressive loading...
April 8, 2024: Materials
#22
REVIEW
Jasper de Boer, Rebecca Barnett, Anthony Cardin, Michelle Cimoli, Lauren Davies, Clare Delany, Benjamin J Dixon, Sue M Evans, Michael W Findlay, Carly Fox, Maria Ftanou, Christopher D Hart, Megan Howard, Tim A Iseli, Andrea Jackson, Sevastjan Kranz, Brian H Le, Ernest Lekgabe, Rachel Lennox, Luke S McLean, Paul J Neeson, Sweet Ping Ng, Lorraine A O'Reilly, Anand Ramakrishnan, David Rowe, Carrie Service, Ankur Singh, Alesha A Thai, Albert Tiong, Tami Yap, David Wiesenfeld
A multidisciplinary approach to the management of tongue cancer is vital for achieving optimal patient outcomes. Nursing and allied health professionals play essential roles within the team. We developed symposia comprising a series of online lectures offering a detailed perspective on the role each discipline and consumer perspective has in the management of patients with tongue cancer. The topics, including epidemiology and prevention, diagnosis, treatment planning, surgery, adjuvant care, and the management of recurrent or metastatic disease, were thoroughly examined...
March 26, 2024: Cancers
#23
REVIEW
Suneesh Anand, Edmond M Cronin
Arrhythmias frequently complicate the course of advanced pulmonary hypertension, often leading to hemodynamic compromise, functional impairment, and mortality. Given the importance of right atrial function in this physiology, the restoration and maintenance of sinus rhythm are of critical importance. In this review, we outline the pathophysiology of arrhythmias and their impact on right heart performance; describe considerations for antiarrhythmic drug selection, anesthetic and periprocedural management; and discuss the results of catheter ablation techniques in this complex and challenging patient population...
March 24, 2024: Journal of Clinical Medicine
#24
JOURNAL ARTICLE
Nsikak Owoh, Jackie Riley, Moses Ashawa, Salaheddin Hosseinzadeh, Anand Philip, Jude Osamor
Mobile crowdsensing (MCS) systems rely on the collective contribution of sensor data from numerous mobile devices carried by participants. However, the open and participatory nature of MCS renders these systems vulnerable to adversarial attacks or data poisoning attempts where threat actors can inject malicious data into the system. There is a need for a detection system that mitigates malicious sensor data to maintain the integrity and reliability of the collected information. This paper addresses this issue by proposing an adaptive and robust model for detecting malicious data in MCS scenarios involving sensor data from mobile devices...
April 7, 2024: Sensors
#25
JOURNAL ARTICLE
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphael Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, James Mullikin, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian T Mayer, Sergio D Rosenzweig, Luigi D Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean-Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage disease. In mice, the loss of Sharpin leads to severe dermatitis due to excessive keratinocyte cell death. Here, we report two individuals with SHARPIN deficiency who manifest autoinflammatory symptoms but unexpectedly no dermatological problems. Fibroblasts and B cells from these individuals showed attenuated canonical NF-κB responses and a propensity for cell death mediated by TNF superfamily members...
April 12, 2024: Nature Immunology
#26
JOURNAL ARTICLE
Anand Subramoney, Guillaume Bellec, Franz Scherr, Robert Legenstein, Wolfgang Maass
Spiking neural networks are of high current interest, both from the perspective of modelling neural networks of the brain and for porting their fast learning capability and energy efficiency into neuromorphic hardware. But so far we have not been able to reproduce fast learning capabilities of the brain in spiking neural networks. Biological data suggest that a synergy of synaptic plasticity on a slow time scale with network dynamics on a faster time scale is responsible for fast learning capabilities of the brain...
April 12, 2024: Scientific Reports
#27
REVIEW
Luke J Weisbrod, Anand Thiraviyam, Raghupathy Vengoji, Nicole Shonka, Maneesh Jain, Winson Ho, Surinder K Batra, Afshin Salehi
Diffuse intrinsic pontine glioma (DIPG) is a childhood malignancy of the brainstem with a dismal prognosis. Despite recent advances in its understanding at the molecular level, the prognosis of DIPG has remained unchanged. This article aims to review the current understanding of the genetic pathophysiology of DIPG and to highlight promising therapeutic targets. Various DIPG treatment strategies have been investigated in pre-clinical studies, several of which have shown promise and have been subsequently translated into ongoing clinical trials...
April 10, 2024: Cancer Letters
#28
JOURNAL ARTICLE
Luís M Ribeiro, Nayan Bhindi, Carly Fox, Anand Ramakrishnan
BACKGROUND: Treatment of scalp malignancies may include the need for craniectomy. The decision to perform cranioplasty is not straightforward and is frequently subjective. The purpose of this study was to assess the clinical outcomes after reconstruction of complex scalp and calvarial defects by comparing patients with and without cranioplasty. METHODS: Retrospective review of the clinical records of a consecutive series of patients who underwent scalp soft tissue reconstruction after craniectomy for malignancy or osteoradionecrosis between 2014 and 2022 at Royal Melbourne Hospital was conducted...
March 26, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
#29
JOURNAL ARTICLE
Pooja Joshi, Deepak Borde, Pramod Apsingekar, Swati Pande, Mangesh Tandale, Anand Deodhar, Sachin Jangle
Sternal wound complications following sternotomy need a multidisciplinary approach in high-risk postoperative cardiac surgical patients. Poorly controlled pain during surgical management of such wounds increases cardiovascular stress and respiratory complications. Multimodal analgesia including intravenous opioids, non-opioid analgesics, and regional anesthesia techniques, like central neuraxial blocks and fascial plane blocks, have been described. Pecto-intercostal fascial plane block (PIFB), a novel technique, has been effectively used in patients undergoing cardiac surgery...
April 1, 2024: Annals of Cardiac Anaesthesia
#30
JOURNAL ARTICLE
Winston Dunn, Yanming Li, Ashwani K Singal, Douglas A Simonetto, Luis A Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, María Ayala-Valverde, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes-López, Carolina Ramirez-Cadiz, Dalia Morales-Arraez, Wei Zhang, Steve Qian, Joseph C Ahn, Seth Buryska, Heer Mehta, Nicholas Dunn, Muhammad Waleed, Horia Stefanescu, Andreea Bumbu, Adelina Horhat, Bashar Attar, Rohit Agrawal, Joaquín Cabezas, Victor Echavaría, Berta Cuyàs, Maria Poca, German Soriano, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, Fátima Higuera-de-la-Tijera, Anand V Kulkarni, P Nagaraja Rao, Patricia Guerra-Salazar, Lubomir Skladaný, Natália Kubánek, Veronica Prado, Ana Clemente-Sanchez, Diego Rincon, Tehseen Haider, Kristina R Chacko, Gustavo A Romero, Florencia D Pollarsky, Juan C Restrepo, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria L Garrido, Sebastián Marciano, Melisa Dirchwolf, Victor Vargas, César Jiménez, David Hudson, Guadalupe García-Tsao, Guillermo Ortiz, Juan G Abraldes, Patrick S Kamath, Marco Arrese, Vijay H Shah, Ramon Bataller, Juan P Arab
BACKGROUND AIMS: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day mortality. Utilizing artificial intelligence (AI) in a global cohort, we sought to derive and validate an enhanced prognostic model. APPROACH AND RESULTS: The Global AlcHep initiative, a retrospective study across 23 centers in 12 countries, enrolled AH patients per NIAAA criteria. Centers were partitioned into derivation (11 centers, 860 patients) and validation cohorts (12 centers, 859 patients)...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#31
Blessymole K Alex, Uttpal Anand, Eapen P Koshy, Abhijit Dey, George Thomas
No abstract text is available yet for this article.
April 12, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
#32
JOURNAL ARTICLE
Renato Salvador, John E Pandolfino, Mario Costantini, C Prakash Gyawali, Jutta Keller, Sumeet Mittal, Sabine Roman, Edoardo Vincenzo Savarino, Roger Tatum, Salvatore Tolone, Frank Zerbib, Giovanni Capovilla, Anand Jain, Priya Kathpalia, Luca Provenzano, Rena Yadlapati
BACKGROUND: In the last two decades the development of high-resolution manometry (HRM) has changed and revolutionized the diagnostic assessment of patients complain foregut symptoms. The role of HRM before and after antireflux procedure remains unclear, especially in surgical practice, where a clear understanding of esophageal physiology and hiatus anatomy is essential for optimal outcome of antireflux surgery (ARS). Surgeons and gastroenterologists (GIs) agree that assessing patients following antireflux procedures can be challenging...
April 12, 2024: Annals of Surgery
#33
JOURNAL ARTICLE
Darius Chapman, Campbell Strong, Kathryn D Tiver, Dhani Dharmaprani, Even Jenkins, Anand N Ganesan
OBJECTIVE: This study addressed the problem of objectively detecting leaks in P2 respirators at point of use, an essential component for healthcare workers' protection. To achieve this, we explored the use of infra-red (IR) imaging combined with machine learning algorithms on the thermal gradient across the respirator during inhalation. RESULTS: The study achieved high accuracy in predicting pass or fail outcomes of quantitative fit tests for flat-fold P2 FFRs. The IR imaging methods surpassed the limitations of self fit-checking...
2024: IEEE open journal of engineering in medicine and biology
#34
JOURNAL ARTICLE
Rumi S Bhattacharjee, Riya J Shah, Nitin S Raithatha, Mamta R Patel
BACKGROUND: Despite recent advances in medicine, the incidence of pre-term birth is increasing globally. Approximately 70% of neonatal deaths, 36% of infant deaths, and 25-50% of cases of neurological impairment in children can be attributed to pre-term births. Identification of risk factors in women, supervised obstetric care during pregnancy, female empowerment, and patient education are strategies to minimize the burden of preterm deliveries. MATERIALS AND METHODS: A prospective cross-sectional study was conducted over a 1-year period among 658 women in the Department of Obstetrics and Gynecology, Pramukhswami Medical College, Anand, Gujarat...
February 2024: Journal of Family Medicine and Primary Care
#35
JOURNAL ARTICLE
Bhavneet Bharti, Monika Garg, Anuradha Nadda, Abha Anand, Neha Kapoor, Nidhi Malhotra
INTRODUCTION: Malnutrition is very common in India and black wheat might be an acceptable solution to this problem. The aim of the study was to assess acceptability of black wheat flour products and factors affecting it among Anganwadi beneficiaries and workers. MATERIALS AND METHODS: This was a mixed-method prospective observational study. All the family members enrolled for supplementary nutrition and Anganwadi workers/helpers of three randomly selected Anganwadi centers were taken in the study...
February 2024: Journal of Family Medicine and Primary Care
#36
JOURNAL ARTICLE
Andrew Fleming, Miranda Galey, Lizi Briggs, Matthew Edwards, Claire Hogg, Shibu John, Sam Wilkinson, Ellie Quinn, Ranjit Rai, Tom Burgoyne, Andy Rogers, Mitali P Patel, Paul Griffin, Steven Muller, Siobhan B Carr, Michael R Loebinger, Jane S Lucas, Anand Shah, Ricardo Jose, Hannah M Mitchison, Amelia Shoemark, Danny E Miller, Deborah J Morris-Rosendahl
Primary ciliary dyskinesia (PCD), a disorder of the motile cilia, is now recognised as an underdiagnosed cause of bronchiectasis. Accurate PCD diagnosis comprises clinical assessment, analysis of cilia and the identification of biallelic variants in one of 50 known PCD-related genes, including HYDIN. HYDIN-related PCD is underdiagnosed due to the presence of a pseudogene, HYDIN2, with 98% sequence homology to HYDIN. This presents a significant challenge for Short-Read Next Generation Sequencing (SR-NGS) and analysis, and many diagnostic PCD gene panels do not include HYDIN...
April 11, 2024: European Journal of Human Genetics: EJHG
#37
JOURNAL ARTICLE
Bhavya Kansal, Aakanksha Anand, Divyani Garg, Anshika Gupta, Ashna Kumar, Suvasini Sharma
OBJECTIVE: Recently, the ILAE Nosology and Definitions Task Force defined diagnostic criteria for epilepsy syndromes. There is paucity of data on the use of these new diagnostic criteria in children with epilepsy, and how these criteria may lead to changes from previous practice. METHODS: This was a retrospective chart review of data of children attending the epilepsy clinic in a tertiary care children's hospital from January 2011 to January 2023. The clinical details such as age at onset, types of seizures, co-morbidities, and results of EEG, MRI and genetic testing were reviewed...
March 27, 2024: Seizure: the Journal of the British Epilepsy Association
#38
JOURNAL ARTICLE
Pablo Hernandez-Lopez, Tushara Vijaykumar, Praveen Anand, Daniel Auclair, Julia Frede, Birgit Knoechel, Jens G Lohr
Although most patients with multiple myeloma respond to treatment initially, therapy resistance develops almost invariably and only a subset of patients show durable responses to immunomodulatory (IMiD) therapies. While the immune microenvironment has been extensively studied in myeloma patients, its composition is currently not used as prognostic markers in clinical routine. We hypothesized that the outcome of immune signaling pathway engagement can be highly variable, depending on which two cellular populations participate in this interaction...
April 11, 2024: Blood Advances
#39
JOURNAL ARTICLE
Rashi Vasisth, Ankita Gurao, Meenakshi Chitkara, Gautam Kumar, Karpenahalli Ranganatha Sriranga, Manishi Mukesh, Mahesh Shivanand Dige, Pawan Singh, Rajeev Anand Kumar Aggarwal, Ranjit Singh Kataria
Selection of the most stably expressed reference genes is key to monitoring accurate target gene expression across any tissue or cell type. The mRNA in spermatozoa stores valuable information related to changes in spermatogenesis due to variations in environmental conditions, especially during heat stress, which affects various sperm functions. Semen quality in buffalo bulls is significantly influenced by the seasons. In the study, a panel of nine genes was evaluated to identify the most stably expressed internal control gene (ICG) for the normalization of real-time gene expression data generated across various seasons for Murrah buffalo bulls' spermatozoa...
April 11, 2024: International Journal of Biometeorology
#40
REVIEW
Madhumita Premkumar, Anil C Anand
Non-cirrhotic portal hypertension (NCPH) is a well-recognized clinico-pathological entity, which is associated with clinical signs and symptoms, imaging, and endoscopic features of portal hypertension (PHT), in absence of cirrhosis. In patients with NCPH without known risk factors of PHT or extrahepatic portal vein thrombosis, the condition is called idiopathic non-cirrhotic portal hypertension (INCPH). There are multiple infectious, immune related causes, systemic diseases, drug and toxin exposures, haematological disorders, and metabolic risk factors that have been associated with this INCPH...
2024: Journal of Clinical and Experimental Hepatology
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