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https://www.readbyqxmd.com/read/30335671/transformational-leadership-practices-and-work-engagement-among-nurse-leaders
#1
Marian K Shaughnessy, Mary T Quinn Griffin, Anand Bhattacharya, Joyce J Fitzpatrick
OBJECTIVE: The aim of this study was to develop better understanding of the leadership characteristics of clinical nurse leaders. BACKGROUND: Transformational leaders are the essential to support nursing in taking control of patient and family care coordination. One prior study of leadership and work engagement among clinical nurse leaders was identified. METHODS: This descriptive correlational study explored the relationship between transformational leadership practices and work engagement among nurse leaders in the United States...
October 17, 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/30335087/severe-clinical-toxicity-caused-by-25i-nbome-confirmed-analytically-using-lc-ms-ms-method
#2
Wojciech Waldman, Maria Kała, Wojciech Lechowicz, Dominika Gil, Jacek Sein Anand
Rhabdomyolysis is a relatively rare, but potentially serious complication of various diseases. Muscular injury and resultant release of electrolytes, myoglobin and other enzymatic proteins e.g. creatine kinase (CK) into circulation may result in multi-organ failure requiring an extensive treatment. Non-traumatic causes of rhabdomyolysis, like poisonings, appear to be much more frequent than traumatic causes. We present the case of a patient who developed exceptionally massive rhabdomyolysis, with CK up to 516 455 U/l, after ingestion of a relatively small dose of a novel psychoactive substance known as "Alice in Wonderland"...
October 18, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/30334671/aurora-kinase-b-sirna-loaded-lactoferrin-nanoparticles-potentiate-the-efficacy-of-temozolomide-in-treating-glioblastoma
#3
Sonali Kumari, Dwaipayan Bhattacharya, Nandini Rangaraj, Sumana Chakarvarty, Anand K Kondapi, Nalam M Rao
AIM: To investigate the efficacy of lactoferrin nanoparticles (LfNPs) in delivering siRNA across the blood-brain barrier to treat glioblastoma multiforme (GBM) and with an additional objective of potentiation of conventional temozolomide (TMZ) chemotherapy. METHODS: Aurora Kinase B (AKB) siRNA-loaded nanoparticles (AKB-LfNPs) were prepared with milk protein, lactoferrin, by water in oil emulsion method. AKB-LfNPs were tested in cell lines and in GBM orthotopic mouse model with and without TMZ treatment...
October 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30333483/machine-learning-and-structural-analysis-of-mycobacterium-tuberculosis-pan-genome-identifies-genetic-signatures-of-antibiotic-resistance
#4
Erol S Kavvas, Edward Catoiu, Nathan Mih, James T Yurkovich, Yara Seif, Nicholas Dillon, David Heckmann, Amitesh Anand, Laurence Yang, Victor Nizet, Jonathan M Monk, Bernhard O Palsson
Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available datasets describing its AMR characteristics demand disparate data-type analyses. Here, we develop a reference strain-agnostic computational platform that uses machine learning approaches, complemented by both genetic interaction analysis and 3D structural mutation-mapping, to identify signatures of AMR evolution to 13 antibiotics. This platform is applied to 1595 sequenced strains to yield four key results...
October 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/30333359/a-randomized-open-label-comparative-study-of-oral-tranexamic-acid-and-tranexamic-acid-microinjections-in-patients-with-melasma
#5
Vinod K Khurana, Rachita R Misri, Swati Agarwal, Akhilesh V Thole, Sachin Kumar, Tanu Anand
Background: Melasma poses a great challenge as its treatment modalities are unsatisfactory. Treatment using tranexamic acid is a novel concept. Aim: This study aimed to compare the therapeutic efficacy and safety of oral tranexamic acid and tranexamic acid microinjections in patients with melasma. Methods: This is a prospective, randomized, open-label study with a sample size of 64, 32 in each treatment arm. Thirty-two patients were administered localized microinjections (4 mg/ml) of tranexamic acid monthly in 1 arm, while in the other arm, 32 were given oral tranexamic acid 250 mg twice a day...
October 17, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/30332967/docking-studies-of-curcumin-and-analogues-with-various-phosphodiesterase-4-subtypes
#6
Yau Xin Yi, Anand Gaurav
INTRODUCTION: The primary aim of this study is to understand the binding of curcumin and its analogues to different PDE4 subtypes and identification of the role of PDE4 subtype inhibition in the anti-inflammatory property of curcumin. Docking analysis has been used to acquire the above mentioned structural information and this has been further used for designing of curcumin derivatives with better anti-inflammatory activity. MATERIALS AND METHOD: Curcumin and its analogues were subjected to docking using PDE4A, PDE4B, PDE4C and PDE4D as the target...
October 16, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/30332642/a-cep290-c-terminal-domain-complements-the-mutant-cep290-of-rd16-mice-in-trans-and-rescues-retinal-degeneration
#7
Suddhasil Mookherjee, Holly Yu Chen, Kevin Isgrig, Wenhan Yu, Suja Hiriyanna, Rivka Levron, Tiansen Li, Peter Colosi, Wade Chien, Anand Swaroop, Zhijian Wu
Mutations in CEP290 cause ciliogenesis defects, leading to diverse clinical phenotypes, including Leber congenital amaurosis (LCA). Gene therapy for CEP290-associated diseases is hindered by the 7.4 kb CEP290 coding sequence, which is difficult to deliver in vivo. The multi-domain structure of the CEP290 protein suggests that a specific CEP290 domain may complement disease phenotypes. Thus, we constructed AAV vectors with overlapping CEP290 regions and evaluated their impact on photoreceptor degeneration in Cep290rd16/rd16 and Cep290rd16/rd16 ;Nrl-/- mice, two models of CEP290-LCA...
October 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/30332388/the-biological-variation-of-plasma-proenkephalin-data-from-a-stable-heart-failure-cohort
#8
Alan H B Wu, Inder Anand
No abstract text is available yet for this article.
October 17, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30326310/oligometastatic-disease-state-is-associated-with-improved-local-control-in-patients-undergoing-3-or-5-fraction-spine-stereotactic-body-radiotherapy
#9
Scott R Silva, Adam Gliniewicz, Brendan Martin, Vikram C Prabhu, Anand V Germanwala, Edward Melian, G Alex Jones, Abhishek A Solanki
BACKGROUND: The objective of our study was to describe the local control (LC) outcomes with 3 or 5 fraction stereotactic body radiotherapy (SBRT) to the spine in patients with oligometastatic (≤ 5 systemic metastases) versus polymetastatic disease (> 5 metastases). METHODS: We retrospectively reviewed outcomes of patients treated with SBRT for spinal metastases. No patients had prior surgical intervention or spinal cord compression. All patients were treated with 3 (median dose 27 Gy; range 24-30 Gy) or 5 fraction (median dose 35 Gy, range 25-40 Gy) SBRT...
October 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30326068/neural-plasticity-following-surgical-correction-of-strabismus-in-monkeys
#10
Mythri Pullela, Mehmet N Agaoglu, Anand C Joshi, Sevda Agaoglu, David K Coats, Vallabh E Das
Purpose: Although widely practiced, surgical treatment of strabismus has varying levels of success and permanence. In this study we investigated adaptive responses within the brain and the extraocular muscles (EOM) that occur following surgery and therefore determine long-term success of the treatment. Methods: Single cell responses were collected from cells in the oculomotor and abducens nuclei before and after two monkeys (M1, M2) with exotropia (divergent strabismus) underwent a strabismus correction surgery that involved weakening of the lateral rectus (LR) and strengthening of the medial rectus (MR) muscle of one eye...
October 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30325993/association-between-surgical-trainee-daytime-sleepiness-and-intraoperative-technical-skill-when-performing-septoplasty
#11
Ya Wei Tseng, S Swaroop Vedula, Anand Malpani, Narges Ahmidi, Kofi D O Boahene, Ira D Papel, Theda C Kontis, Jessica Maxwell, John R Wanamaker, Patrick J Byrne, Sonya Malekzadeh, Gregory D Hager, Lisa E Ishii, Masaru Ishii
Importance: Daytime sleepiness in surgical trainees can impair intraoperative technical skill and thus affect their learning and pose a risk to patient safety. Objective: To determine the association between daytime sleepiness of surgeons in residency and fellowship training and their intraoperative technical skill during septoplasty. Design, Setting, and Participants: This prospective cohort study included 19 surgical trainees in otolaryngology-head and neck surgery programs at 2 academic institutions (Johns Hopkins University School of Medicine and MedStar Georgetown University Hospital)...
October 11, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/30324588/coupling-of-blood-pressure-and-subarachnoid-space-oscillations-at-cardiac-frequency-evoked-by-handgrip-and-cold-tests-a-bispectral-analysis
#12
Marcin Gruszecki, Yurii Tkachenko, Jacek Kot, Marek Radkowski, Agnieszka Gruszecka, Krzysztof Basiński, Monika Waskow, Wojciech Guminski, Jacek Sein Anand, Jerzy Wtorek, Andrzej F Frydrychowski, Urszula Demkow, Pawel J Winklewski
The aim of the study was to assess blood pressure-subarachnoid space (BP-SAS) width coupling properties using time-frequency bispectral analysis based on wavelet transforms during handgrip and cold tests. The experiments were performed on a group of 16 healthy subjects (F/M; 7/9) of the mean age 27.2 ± 6.8 years and body mass index of 23.8 ± 4.1 kg/m2 . The sequence of challenges was first handgrip and then cold test. The handgrip challenge consisted of a 2-min strain, indicated by oral communication from the investigator, at 30% of maximum strength...
October 16, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30324498/leptin-and-the-intervertebral-disc-a-biochemical-link-exists-between-obesity-intervertebral-disc-degeneration-and-low-back-pain-an-in-vitro-study-in-a-bovine-model
#13
Anand H Segar, Jeremy C T Fairbank, Jill Urban
PURPOSE: The aim of this study was to identify the effects of leptin upon the intervertebral disc (IVD) and to determine whether these responses are potentiated within an environment of existing degeneration. Obesity is a significant risk factor for low back pain (LBP) and IVD degeneration. Adipokines, such as leptin, are novel cytokines produced primarily by adipose tissue and have been implicated in degradative and inflammatory processes. Obese individuals are known to have higher concentrations of serum leptin, and IVD cells express leptin receptors...
October 15, 2018: European Spine Journal
https://www.readbyqxmd.com/read/30323917/distraction-osteogenesis-for-brachymetatarsia-using-initial-circular-fixator-and-early-trans-fixation-metatarsal-k-wires-a-series-of-three-cases-%C3%A2
#14
Pradeep Kumar, Anand Pillai, Jo-Ann Bate, Joshua Henry
Brachymetatarsia is a rare forefoot deformity predominantly affecting the fourth metatarsal. Current treatment include gradual lengthening by distraction osteogenesis using an external fixator or single-stage lengthening with bone grafting or a combination of the above two procedures. Our aim was to assess outcomes and complications of a novel technique for gradual metatarsal lengthening using a circular fixator. The procedure was performed on three female patients with unilateral congenital shortening of the fourth ray...
October 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30323626/pembrolizumab-for-the-treatment-of-patients-with-recurrent-locally-advanced-or-metastatic-gastric-or-gastroesophageal-junction-cancer-an-evidence-based-review-of-place-in-therapy
#15
REVIEW
Rutika Mehta, Anand Shah, Khaldoun Almhanna
Gastric and esopahgeal cancers account for the six most common causes of cancer death worldwide. Locally advanced resectable cancers have a 5-year life expectancy of 30%. Despite use of chemotherapy, median overall survival for stage IV cancer rarely exceeds 1 year. A subset of gastric cancers such as microsatellite-instable tumor and Epstein-Barr virus-positive tumors have a rich immune infiltrate that makes them more responsive to immune-directed therapies. Tumors can evade T-cell-mediated "immune surveillance" by activating the programmed cell death receptor 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30323294/using-drosophila-behavioral-assays-to-characterize-terebrid-venom-peptide-bioactivity
#16
Anders Eriksson, Prachi Anand, Juliette Gorson, Corina Grijuc, Elina Hadelia, James C Stewart, Mandë Holford, Adam Claridge-Chang
The number of newly discovered peptides from the transcriptomes and proteomes of animal venom arsenals is rapidly increasing, resulting in an abundance of uncharacterized peptides. There is a pressing need for a systematic, cost effective, and scalable approach to identify physiological effects of venom peptides. To address this discovery-to-function gap, we developed a sequence driven:activity-based hybrid approach for screening venom peptides that is amenable to large-venom peptide libraries with minimal amounts of peptide...
October 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30323158/use-of-needle-based-confocal-laser-endomicroscopy-in-the-diagnosis-and-management-of-pancreatic-cyst-lesions
#17
Kapil Anand, Michel Kahaleh, Amy Tyberg
No abstract text is available yet for this article.
September 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/30322268/examining-adherence-to-activity-monitoring-devices-to-improve-physical-activity-in-adults-with-cardiovascular-disease-a-systematic-review
#18
Tania S Marin, Constance Kourbelis, Jonathon Foote, Peter Newman, Alex Brown, Mark Daniel, Neil T Coffee, Stephen J Nicholls, Anand Ganesan, Vincent L Versace, Hannah Beks, Christine A Haedtke, Robyn A Clark
Background Activity monitoring devices are currently being used to facilitate and monitor physical activity. No prior review has examined adherence to the use of activity monitoring devices amongst adults with cardiovascular disease. Methods Literature from June 2012 to October 2017 was evaluated to examine the extent of adherence to any activity monitoring device used to collect objective physical activity data. Randomized control trials comparing usual care against the use of an activity monitoring device, in a community intervention for adults from any cardiovascular diagnostic group, were included...
October 15, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/30321309/inhibition-of-gsk-3-to-induce-cardiomyocyte-proliferation-a-recipe-for-in-situ-cardiac-regeneration
#19
Anand Prakash Singh, Prachi Umbarkar, Yuanjun Guo, Thomas Force, Manisha Gupte, Hind Lal
With an estimated 38 million current patients, heart failure (HF) is a leading cause of morbidity and mortality worldwide. Although the etiology differs, HF is largely a disease of cardiomyocyte (CM) death or dysfunction. Due to the famously limited amount of regenerative capacity of the myocardium, the only viable option for advanced HF patients is cardiac transplantation; however, donor's hearts are in very short supply. Thus, novel regenerative strategies are urgently needed to reconstitute the injured hearts...
October 15, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/30320289/1-h-1-2-3-triazole-tethered-nitroimidazole-isatin-conjugates-synthesis-docking-and-anti-proliferative-evaluation-against-breast-cancer
#20
Sumit Kumar, Sourav Taru Saha, Liang Gu, Gabriella Palma, Shanen Perumal, Ashona Singh-Pillay, Parvesh Singh, Amit Anand, Mandeep Kaur, Vipan Kumar
1 H -1,2,3-Triazole tethered imidazole-isatin and imidazole-isatin-thiosemicarbazone conjugates were synthesized and evaluated against MCF-7 and MDA-MB-231 cell lines. Antiproliferative activities of the synthesized conjugates revealed an optimum combination of longer alkyl chain length as spacer and a halogen-substituent on the isatin ring as a pre-requisite for good activity. The compound 6g with an optimum combination of chloro-substituent at C-5 position of isatin ring and a butyl chain length proved to be most active and noncytotoxic with IC50s of 54...
September 30, 2018: ACS Omega
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