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Florentine Schreiner, Gurpreet Anand, Felix Beuschlein
Endocrine active adrenal tumors are associated with a relevant risk of complications during surgery, either due to direct hemodynamic effects of the hormone excess or due to hormone related comorbidities. Over the last decades, careful preoperative evaluation and improved peri-interventional medical management of affected patients has resulted in a significant reduction of perioperative complications. In addition, improvement in anesthesia and surgical techniques with the feasibility of laparoscopic adrenalectomy have contributed to reduce morbidity...
August 14, 2018: Experimental and Clinical Endocrinology & Diabetes
Natesan Anand Vijai, Palanisamy Senthilnathan, Vikram Annamaneni, Sandeep C Sabnis, Arvinder Singh Soin, Chinnusamy Palanivelu
Liver transplantation is a ray of hope for thousands of patients with end-stage liver disease but is currently challenged by the scarcity of donor organs worldwide. Unlike kidney transplantation where minimally invasive donor organ procurement has almost become a norm, laparoscopic procurement of hemi-liver from a living donor is still in the infancy of development, at least in the Indian sub-continent. Minimally invasive surgery has made its way into different procedures of hepatobiliary and pancreatic surgery, but only a few centres in the world are performing pure laparoscopic donor hepatectomy...
August 7, 2018: Journal of Minimal Access Surgery
Anand A Dalal, Geneviève Gauthier, Patrick Gagnon-Sanschagrin, Rebecca Burne, Annie Guérin, Polly Niravath, Tania Small
INTRODUCTION: Premenopausal women with hormone receptor positive (HR+) and human epidermal growth factor receptor-2-negative (HER2-) advanced breast cancer (aBC) often present with aggressive tumor types that lead to poor prognosis, high rates of recurrence, and mortality. Although clinical guidelines provide evidence-based recommendations for optimal treatment and monitoring, there is a dearth of information regarding treatment and monitoring patterns in clinical practice. In this study, we describe treatment and monitoring patterns among premenopausal women with HR+/HER2- aBC in real-world practice...
August 13, 2018: Advances in Therapy
T R Monisha, Mukram Ismailsab, Ramesh Masarbo, Anand S Nayak, T B Karegoudar
A bacterium Stenotrophomonas sp. TRMK2 capable of utilizing cinnamic acid was isolated from agro-industrial waste by enrichment culture technique. This strain completely utilizes 5 mM cinnamic acid within 18 h of incubation. The different metabolites formed during the degradation of cinnamic acid were characterized by GC-HRMS. The involvement of various enzymes, namely cinnamate reductase, 3-phenylpropionic acid hydroxylase, p -hydroxybenzoic acid hydroxylase and protocatechuate 3,4-dioxygenase in cinnamic acid degradation was demonstrated...
August 2018: 3 Biotech
Jeetvan G Patel, Anna D Coutinho, Orsolya E Lunacsek, Anand A Dalal
Purpose: This study aimed to measure the true burden of COPD by calculating incremental direct and indirect costs. Direct medical resource use, productivity metrics, and COPD-specific resource use and costs were also evaluated. Patients and methods: This was a retrospective, observational, matched cohort study using administrative claims data from the Truven Health MarketScan® Commercial Claims and Encounters and the Health and Productivity Management databases (2007-2010)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Sajjad Desai, Niraj Rathi, Anand Kawade, Padmasani Venkatramanan, Ritabrata Kundu, Sanjay K Lalwani, A P Dubey, J Venkateswara Rao, D Narayanappa, Radha Ghildiyal, Nithya J Gogtay, P Venugopal, Sonali Palkar, Renuka Munshi, Ashish Bavdekar, Sanjay Juvekar, Nupur Ganguly, Prabal Niyogi, Kheya Ghosh Uttam, Alpana Kondekar, Dipti Kumbhar, Smilu Mohanlal, Mukesh C Agarwal, Parvan Shetty, Kalpana Antony, Bhagwat Gunale, Abhijeet Dharmadhikari, Jagdish Deshpande, Uma Nalavade, Deepa Sharma, Anurag Bansal, Yuxiao Tang, Jorge Flores, Prasad S Kulkarni
BACKGROUND: A newly developed bovine-human reassortant pentavalent vaccine (BRV-PV, ROTASIIL®) was tested for its potential effect on the immunogenicity of concomitantly administered EPI vaccines in infants in a randomized controlled study in India. METHODS: In this Phase III, multicenter, open label, randomized, controlled study, three doses of BRV-PV or two doses of Rotarix® and one dose of placebo were given to healthy infants at 6, 10, and 14 weeks of age...
August 10, 2018: Vaccine
Tiew-Hwa K Teng, Jasper Tromp, Wan Ting Tay, Inder Anand, Wouter Ouwerkerk, Vijay Chopra, Gurpreet S Wander, Jonathan Jl Yap, Michael R MacDonald, Chang Fen Xu, Yvonne Mf Chia, Wataru Shimizu, A Mark Richards, Adriaan Voors, Carolyn Sp Lam
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs), β blockers, and mineralocorticoid receptor antagonists (MRAs) are of proven benefit and are recommended by guidelines for management of patients with heart failure and reduced ejection fraction (HFrEF). We aimed to examine the first prospective multinational data from Asia on prescribing patterns of guideline-directed medical therapies and analyse its effect on outcomes. METHODS: In the prospective multinational ASIAN-HF registry (with enrolment from 46 centres in 11 countries in Asia), we enrolled patients aged 18 years or older, with symptomatic heart failure (stage C, with at least one episode of decompensated heart failure in the past 6 months that resulted in admission to hospital or was treated in an outpatient clinic) and left ventricular systolic dysfunction (ejection fraction ≤40% on baseline echocardiography, consistent with 2016 European Society of Cardiology guidelines)...
September 2018: Lancet Global Health
N Ekin Akalan, Shavkat Kuchimov, Adnan Apti, Yener Temelli, Merve Ören, Anand Nene
Muscle strength is usually measured using isometric hand-held dynamometers (HHDs) in the clinic. However, during functional activities, the muscle acts more dynamically. The aim of this study was to investigate the relation between clinically measured plantar flexor (PF) muscle strength (PFMS) and laboratory measurements of peak ankle plantar flexion power generation (APFPG), peak ankle moment (PAM), peak plantar flexion velocity (PFV) and mean gait velocity in healthy participants. METHODS: The maximum PFMS on non-dominant sides in 18 able-bodied persons 23...
July 27, 2018: Journal of Back and Musculoskeletal Rehabilitation
Alireza Abdolrasouli, Andrew Scourfield, Johanna Rhodes, Anand Shah, J Stuart Elborn, Matthew C Fisher, Silke Schelenz, Darius Armstrong-James
OBJECTIVES: To evaluate the prevalence of triazole-resistant Aspergillus fumigatus and common molecular cyp51A polymorphisms amongst clinical isolates in a specialised cardio-thoracic centre in London, United Kingdom. METHODS: All A. fumigatus isolates were prospectively analysed from April 2014 to March 2016. Isolates were screened with a 4-well VIPcheck™ plate to assess triazole susceptibility. Resistance was confirmed with standard microbroth dilution method according to EUCAST guidelines...
August 10, 2018: International Journal of Antimicrobial Agents
Anand Kumthekar, Philipp W Raess, Daniela Ghetie
No abstract text is available yet for this article.
August 10, 2018: American Journal of Medicine
P Shillo, D Selvarajah, M Greig, R Gandhi, G Rao, I D Wilkinson, P Anand, S Tesfaye
AIM: Recent studies have reported an association between low vitamin D levels and diabetic peripheral neuropathy. However, many of these did not differentiate between people with painful diabetic peripheral neuropathy and those with painless diabetic peripheral neuropathy, or assess major confounding factors including sunlight exposure and daily activity. Our study addressed these limitations and evaluated vitamin D levels in people with carefully phenotyped diabetic peripheral neuropathy and controls...
August 13, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Parashar Koirala, Amit Anand
Major depression often presents in patients with a history of both depression and mania, although patients may not have the insight to report manic symptoms as problematic. Distinguishing pure (unipolar) depression from bipolar depression is important for prognostic and treatment reasons. Once identified, bipolar depression can be adequately and safely treated.
August 2018: Cleveland Clinic Journal of Medicine
Ishaq Lat, Mitchell J Daley, Anand Shewale, Mark H Pangrazzi, Drayton Hammond, Keith M Olsen
OBJECTIVE: This study was conducted to describe the prevalence, epidemiology, and clinical outcomes of multidrug resistant (MDR) organism (MDRO) pneumonia in critically ill patients. METHODS: A multicenter, prospective, observational study of patients admitted to 60 intensive care units (ICUs), from 34 hospitals, in the United States from November-December 2016. Adults (>18 years) receiving antimicrobial therapy at least 5 days for pneumonia were included. Patients were classified into 2 categories, with or without MDRO, and subcategorized by pneumonia type...
August 12, 2018: Pharmacotherapy
Brian J Yun, Robert M Rodriguez, Anand M Prabhakar, David A Peak, DaMarcus E Baymon, Ali S Raja
INTRODUCTION: Increased use of computed tomography (CT) during injury-related Emergency Department (ED) visits has been reported, despite increased awareness of CT radiation exposure risks. We investigated national trends in the use of chest CT during injury-related ED visits between 2012 and 2015. METHODS: Analyzing injury-related ED visits from the 2012-2015 United States (U.S.) National Hospital Ambulatory Medical Care Survey (NHAMCS), we determined the percentage of visits that had a chest CT and the diagnostic yield of these chest CTs for clinically-significant findings...
August 8, 2018: American Journal of Emergency Medicine
Shu Fen Tan, Geeta Bisht, Utkarsh Anand, Michel Bosman, Xin Ee Yong, Utkur Mirsaidov
One-pot wet-chemical synthesis is a simple way to obtain nanoparticles (NPs) with a well-defined shape and composition. However, achieving good control over NP synthesis would require a comprehensive understanding of the mechanisms of NP formation, something that is hard to achieve experimentally. Here, we study the formation of gold (Au) core - palladium (Pd) shell NPs under kinetically and thermodynamically controlled reaction conditions using in situ liquid cell transmission electron microscopy (TEM). By controlling the reaction temperature, we demonstrate that it is possible to tune the shape of Au nanorods (NR) to Au-Pd arrow-headed structures or to cuboidal core-shell NPs...
August 12, 2018: Journal of the American Chemical Society
Ignacio Jusue-Torres, Alicia Hulbert, Arpita A Germanwala, Chirag R Patel, Anand V Germanwala
OBJECTIVE: The authors' objective was to identify the 100 most-cited research articles on craniopharyngiomas. METHODS: The Thomson Reuters Web of Science service was queried for the years 1900-2017 without language restrictions. Articles were sorted in descending order of the number of times they were cited by other studies, and all titles and abstracts were screened to identify the research areas of the top 100 articles. The number of citations per year was calculated...
August 9, 2018: World Neurosurgery
Vidya Sagar Reddy, Brijesh Yadav, Chhote Lal Yadav, Mukul Anand, Dilip Kumar Swain, Devendra Kumar, Deepika Kritania, Arun Kumar Madan, Jitender Kumar, Sarvajeet Yadav
Cryopreservation results in substantial deterioration of heat shock protein 70 (HSP70) and ultra-structural changes in sperm organelles, resulting in a marked reduction in post-thaw semen quality. The present study was aimed to explicate the effect of sericin supplementation on expression profile of HSP70, redox status and post-thaw semen quality in Barbari goat. Five Barbari bucks were used to collect thirty semen ejaculates by using artificial vagina and each ejaculate was divided into three aliquots to which sericin was supplemented at 0% (Control), 0...
August 9, 2018: Cryobiology
Durga Chougule, Milind Nadkar, Krishnamurthy Venkataraman, Anjali Rajadhyaksha, Niwrutti Hase, Tukaram Jamale, Seema Kini, Prasad Khadilkar, Vidya Anand, Manisha Madkaikar, Vandana Pradhan
BACKGROUND: Adipokines are chemical mediators released from adipose tissue involved in regulation of appetite, insulin sensitivity, immune system and inflammatory responses. Adipokines contributes to low grade inflammatory response in autoimmune disease like Systemic Lupus Erythematosus (SLE) but the pathophysiology is yet not clear. The aim of this study is to understand role of adipokine interactions in SLE disease pathogenesis. METHODS: Sixty newly diagnosed treatment naïve SLE patients fulfilling the ACR criteria and forty age-sex matched healthy subjects were enrolled in thiscase-control study...
August 8, 2018: Cytokine
Andrew J Chappell, Daniel M Allwood, Rebecca Johns, Samantha Brown, Kiran Sultana, Annie Anand, Trevor Simper
BACKGROUND: Use of supplements to aid performance is common practice amongst recreationally active individuals, including those without a sufficient evidence base. This investigation sought to assess whether acute supplementation with 8 g of citrulline malate (CM) (1.11: 1 ratio) would improve anaerobic performance. METHODS: A randomised double blind placebo control trial was employed, using a counterbalanced design. We recruited recreationally active men and women to take part in an isokinetic chair protocol, based on German Volume Training (GVT) whereby participants attempted to perform 10 sets of 10 repetitions against a force representing 70% of their peak concentric force...
August 10, 2018: Journal of the International Society of Sports Nutrition
Anchu Ashok, Anand Kumar, Faris Tarlochan
Herein, we report the synthesis of silver-cobalt nanopowders using three different modes of solution combustion synthesis, and we present the effects of the synthesis conditions on particle morphology. The synthesized nanoparticles were characterized using X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), UV-Visible spectrophotometer (UV-vis), Transmission electron microscopy (TEM), and X-Ray Photoelectron Spectroscopy (XPS) to understand the structural and elemental properties...
August 9, 2018: Nanomaterials
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