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https://www.readbyqxmd.com/read/30514800/mutational-and-transcriptomic-profiling-of-acute-leukemia-of-ambiguous-lineage-reveals-obscure-but-clinically-important-lineage-bias
#1
Zhen-Tang Lao, Ling Wen Ding, Omer An, Norimichi Hattori, Qiao-Yang Sun, Kar-Tong Tan, Anand Mayakonda, Wong Gee Chuan, Vikas Madan, De-Chen Lin, Henry Yang, H Phillip Koeffler
Acute leukemia of ambiguous lineage (ALAL) is a rare group of blood cancers that cannot be clearly classified into either myeloid or lymphoid lineage through traditional immunophenotyping (2016 World Health Organization classification). In this study, we performed exome and transcriptome sequencing of 15 diagnosis/relapse samples to identify mutations of this disease. Remarkably, genes involved in DNA repair pathway were frequently mutated and occurred in 80% of the samples. In addition, well known mutations of hematopoietic neoplasms were found in these samples, such as DNMT3A, RUNX1, NOTCH1 and NRAS...
December 4, 2018: Haematologica
https://www.readbyqxmd.com/read/30513337/styryl-cinnamate-hybrid-inhibits-glioma-by-alleviating-translation-bioenergetics-and-other-key-cellular-responses-leading-to-apoptosis
#2
Kiran Rawat, Amit Shard, Manali Jadhav, Mayuri Gandhi, Prince Anand, Rituraj Purohit, Yogendra Padwad, Arun K Sinha
Gliomas are lethal and aggressive form of brain tumors with resistance to conventional radiation and cytotoxic chemotherapies; inviting continuous efforts for drug discovery and drug delivery. Interestingly, small molecule hybrids are one such pharmacophore that continues to capture interest owing to their pluripotent medicinal effects. Accordingly, we earlier reported synthesis of potent Styryl-cinnamate hybrids (analogues of Salvianolic acid F) along with its plausible mode of action (MOA). We explored iTRAQ-LC/MS-MS technique to deduce differentially expressed landscape of native & phospho-proteins in treated glioma cells...
December 1, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30511355/cuprizone-induced-graded-oligodendrocyte-vulnerability-is-regulated-by-the-transcription-factor-dna-damage-inducible-transcript-3
#3
Felix Fischbach, Julia Nedelcu, Patrizia Leopold, Jiangshan Zhan, Tim Clarner, Lara Nellessen, Christian Beißel, Yasemin van Heuvel, Anand Goswami, Joachim Weis, Bernd Denecke, Christoph Schmitz, Tanja Hochstrasser, Stella Nyamoya, Marion Victor, Cordian Beyer, Markus Kipp
Oligodendrocytes are integral to efficient neuronal signaling. Loss of myelinating oligodendrocytes is a central feature of many neurological diseases, including multiple sclerosis (MS). The results of neuropathological studies suggest that oligodendrocytes react with differing sensitivity to toxic insults, with some cells dying early during lesion development and some cells being resistant for weeks. This proposed graded vulnerability has never been demonstrated but provides an attractive window for therapeutic interventions...
December 3, 2018: Glia
https://www.readbyqxmd.com/read/30511301/dietary-pattern-regulates-fatty-acid-desaturase-1-gene-expression-in-indian-pregnant-women-to-spare-overall-long-chain-polyunsaturated-fatty-acids-levels
#4
Kalpana Joshi, Maithili Gadgil, Anand Pandit, Suhas Otiv, Kumar S D Kothapalli, J Thomas Brenna
The aim of this study was to determine if the dietary pattern of pregnant women has any compensatory effect on the fatty acid desaturase (FADS) gene expression, thus enhancing the conversion of precursors to long chain polyunsaturated fatty acids (LCPUFA) to spare the overall LCPUFA levels. The dietary intake of plant-based precursor polyunsaturated fatty acids (PUFA) influences circulating levels of LCPUFA. We hypothesized that low LCPUFA diets during pregnancy would compensate by higher expression of FADS genes to enhance the conversion of precursors to LCPUFA to spare the overall LCPUFA levels...
December 3, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30511146/humanizing-an-invisible-population-in-india-voices-from-bisexual-men-concerning-identity-life-experiences-and-sexual-health
#5
Swagata Banik, Brian Dodge, Megan Schmidt-Sane, Murugesan Sivasubramanian, Jessamyn Bowling, Shruta Mengle Rawat, Alpana Dange, Vivek Anand
Research examining the sexual identities, behaviors, and experiences of bisexual men outside of Western contexts (including in India) is limited. Individuals who self-identify as bisexual due to their orientation toward partners of more than one gender face distinct psychosocial challenges relative to exclusively heterosexual, gay/lesbian, or other individuals. We conducted four focus group discussions (n = 22) and in-depth interviews (n = 50) with self-identified bisexual men (age 18 years and older) who were recruited from the metropolitan area of Mumbai, India, between June and August 2013...
December 3, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/30510277/a-dna-nanomachine-chemically-resolves-lysosomes-in-live-cells
#6
KaHo Leung, Kasturi Chakraborty, Anand Saminathan, Yamuna Krishnan
Lysosomes are multifunctional, subcellular organelles with roles in plasma membrane repair, autophagy, pathogen degradation and nutrient sensing. Dysfunctional lysosomes underlie Alzheimer's disease, Parkinson's disease and rare lysosomal storage diseases, but their contributions to these pathophysiologies are unclear. Live imaging has revealed lysosome subpopulations with different physical characteristics including dynamics, morphology or cellular localization. Here, we chemically resolve lysosome subpopulations using a DNA-based combination reporter that quantitatively images pH and chloride simultaneously in the same lysosome while retaining single-lysosome information in live cells...
December 3, 2018: Nature Nanotechnology
https://www.readbyqxmd.com/read/30508603/in-vitro-analysis-of-synthetic-peptides-in-blocking-the-entry-of-dengue-virus
#7
Asnet Mary John, Akanitt Jittmittraphap, Siriporn Chattanadee, A Alwin Prem Anand, R Shenbagarathai, Pornsawan Leaungwutiwong
Dengue fever is the most prevalent arthropod-borne viral disease, and no specific therapeutic or promising antiviral drug is available for its treatment. Peptide inhibitors are less toxic than synthetic compounds and have found proven effective against viral infections. Here, three peptides that mimic part of the E protein of the dengue virus (DENV) were synthesized and evaluated for their inhibitory activity against four serotypes of DENV in African green monkey kidney (Vero) and rhesus macaque (Macaca mulatta) monkey kidney (LLC-MK2) cell lines...
November 30, 2018: Virus Research
https://www.readbyqxmd.com/read/30506627/in-vivo-multiphoton-microscopy-imaging-of-melasma
#8
Griffin Lentsch, Mihaela Balu, Joshua Williams, Sanghoon Lee, Ronald M Harris, Karsten König, Anand Ganesan, Bruce J Tromberg, Nirmala Nair, Uma Santhanam, Manoj Misra
Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess the elastosis severity. We employed a clinical MPM tomograph to image in-vivo morphological features in melasma lesions and adjacent normal skin in 12 patients. We imaged dermal melanophages in most dermal melasma lesions and occasionally in epidermal melasma...
December 1, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/30505105/reply-management-of-vascular-anomalies-review-of-institutional-management-algorithm
#9
COMMENT
Shamendra Anand Sahu, Ankur Goyal, Shruti Marwah, Aniket Dave, Moumita De, Deepti Gupta
No abstract text is available yet for this article.
May 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/30505094/adipofascial-perforator-flaps-its-role-in-reconstruction-of-soft-tissue-defects-of-lower-leg-and-ankle
#10
Deepak Nanda, Shamendra Anand Sahu, Durga Karki, Sanjay Kumar, Amrita Mandal
Background: Despite advances in surgical skills, adipofascial flaps are still less preferred option for coverage of leg defect. We evaluate the use of perforator-based adipofascial flap in small-to-medium-sized soft-tissue defects in the lower limb. Patients and Methods: After localisation of perforators along the major axial vessels in the lower limb using handheld Doppler, adipofascial flap based on the nearest best perforator of anterior tibial artery, posterior tibial artery and peroneal artery was raised to cover soft-tissue defect in 21 patients...
May 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/30503779/engineering-an-osmosensor-by-pivotal-histidine-positioning-within-disordered-helices
#11
Madhubrata Ghosh, Loo Chien Wang, Roland Huber, Yunfeng Gao, Leslie K Morgan, Nikhil Kumar Tulsian, Peter Bond, Linda J Kenney, Ganesh S Anand
Histidine kinases (HKs) funnel diverse environmental stimuli into a single autophosphorylation event at a conserved histidine residue. The HK EnvZ is a global sensor of osmolality and cellular acid pH. In previous studies, we discovered that osmosensing in EnvZ was mediated through osmolyte-induced stabilization of the partially disordered helical backbone spanning the conserved histidine autophosphorylation site (His243 ). Here, we describe how backbone stabilization leads to changes in the microenvironment of His243 , resulting in enhanced autophosphorylation through relief of inhibition and repositioning of critical side chains and imidazole rotamerization...
November 1, 2018: Structure
https://www.readbyqxmd.com/read/30501583/a-survey-of-vascular-specialists-practice-patterns-of-inferior-vena-cava-filter-placement-and-retrieval
#12
Anand Brahmandam, Laura Skrip, Bauer Sumpio, Jeffrey Indes, Alan Dardik, Timur Sarac, John Rectenwald, Cassius Iyad Ochoa Chaar
OBJECTIVES: The placement of inferior vena cava filters (IVCF) continues to rise. Vascular specialists adopt different practices based on local expertise. This study was performed to assess the attitudes of vascular specialists towards the placement and retrieval of IVCF. METHODS: An online survey of 28 questions related to practice patterns regarding IVCF was administered to 1429 vascular specialists. Vascular specialists were categorized as low volume if they place less than three IVCF per month and high volume if they place at least three IVCF per month...
December 1, 2018: Vascular
https://www.readbyqxmd.com/read/30501110/design-of-a-novel-and-selective-irak4-inhibitor-using-topological-water-network-analysis-and-molecular-modeling-approaches
#13
Myeong Hwi Lee, Anand Balupuri, Ye-Rim Jung, Sungwook Choi, Areum Lee, Young Sik Cho, Nam Sook Kang
Protein kinases are deeply involved in immune-related diseases and various cancers. They are a potential target for structure-based drug discovery, since the general structure and characteristics of kinase domains are relatively well-known. However, the ATP binding sites in protein kinases, which serve as target sites, are highly conserved, and thus it is difficult to develop selective kinase inhibitors. To resolve this problem, we performed molecular dynamics simulations on 26 kinases in the aqueous solution, and analyzed topological water networks (TWNs) in their ATP binding sites...
November 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30500822/jmjd5-links-cry1-function-and-proteasomal-degradation
#14
Anand R Saran, Diana Kalinowska, Sangphil Oh, Ralf Janknecht, Luciano DiTacchio
The circadian oscillator is a molecular feedback circuit whose orchestration involves posttranslational control of the activity and protein levels of its components. Although controlled proteolysis of circadian proteins is critical for oscillator function, our understanding of the underlying mechanisms remains incomplete. Here, we report that JmjC domain-containing protein 5 (JMJD5) interacts with CRYPTOCHROME 1 (CRY1) in an F-box/leucine-rich repeat protein 3 (FBXL3)-dependent manner and facilitates targeting of CRY1 to the proteasome...
November 30, 2018: PLoS Biology
https://www.readbyqxmd.com/read/30499198/atherectomy-in-below-the-knee-endovascular-interventions-one-year-outcomes-from-the-xlpad-registry
#15
Houman Khalili, Haekyung Jeon-Slaughter, Ehrin J Armstrong, Amutharani Baskar, Ishita Tejani, Nicolas W Shammas, Anand Prasad, Mazen Abu-Fadel, Emmanouil S Brilakis, Subhash Banerjee
BACKGROUND: Use of atherectomy for the treatment of peripheral arterial disease (PAD) is increasing as an adjunctive treatment to either conventional or drug-coated balloon angioplasty. There is limited data on atherectomy outcomes in below-the-knee (BTK) endovascular interventions. METHODS: Data from the multicenter Excellence in Peripheral Artery Disease (XLPAD) registry (NCT01904851) were analyzed to examine predictors of atherectomy use and its associated 1-year patency rate...
November 30, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30498744/mini-and-customized-low-cost-bioreactors-for-optimized-high-throughput-generation-of-tissue-organoids
#16
EDITORIAL
Michael A Phelan, Peter I Lelkes, Anand Swaroop
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/30498662/antibiotic-susceptibility-profile-of-pediococcus-spp-from-diverse-sources
#17
Varsha Singla, Surajit Mandal, Poonam Sharma, Santosh Anand, Sudhir Kumar Tomar
The aim of the present study was to assess the antibiotic susceptibility profile of Pediococcus strains from diverse sources. From a total of 115 dairy and non-dairy samples, 40 Pediococcus strains were isolated. Their biochemical and molecular characterization confirmed them as P. pentosaceus and P. acidilactici . All the 40 identified isolates were evaluated for antibiotic susceptibility using disc diffusion assay against a total of 20 antibiotics. The isolates exhibited varied range of responses towards the antibiotics depending on the strain type, source and location of isolation...
December 2018: 3 Biotech
https://www.readbyqxmd.com/read/30497991/novel-approach-to-cluster-patient-generated-data-into-actionable-topics-case-study-of-a-web-based-breast-cancer-forum
#18
Josette Jones, Meeta Pradhan, Masoud Hosseini, Anand Kulanthaivel, Mahmood Hosseini
BACKGROUND: The increasing use of social media and mHealth apps has generated new opportunities for health care consumers to share information about their health and well-being. Information shared through social media contains not only medical information but also valuable information about how the survivors manage disease and recovery in the context of daily life. OBJECTIVE: The objective of this study was to determine the feasibility of acquiring and modeling the topics of a major online breast cancer support forum...
November 29, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/30496486/super-enhancer-associated-meis1-promotes-transcriptional-dysregulation-in-ewing-sarcoma-in-co-operation-with-ews-fli1
#19
Lehang Lin, Moli Huang, Xianping Shi, Anand Mayakonda, Kaishun Hu, Yan-Yi Jiang, Xiao Guo, Li Chen, Brendan Pang, Ngan Doan, Jonathan W Said, Jianjun Xie, Sigal Gery, Xu Cheng, Zhaoyu Lin, Jinsong Li, Benjamin P Berman, Dong Yin, De-Chen Lin, H Phillip Koeffler
As the second most common malignant bone tumor in children and adolescents, Ewing sarcoma is initiated and exacerbated by a chimeric oncoprotein, most commonly, EWS-FLI1. In this study, we apply epigenomic analysis to characterize the transcription dysregulation in this cancer, focusing on the investigation of super-enhancer and its associated transcriptional regulatory mechanisms. We demonstrate that super-enhancer-associated transcripts are significantly enriched in EWS-FLI1 target genes, contribute to the aberrant transcriptional network of the disease, and mediate the exceptional sensitivity of Ewing sarcoma to transcriptional inhibition...
November 28, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30496172/integrating-evidence-models-and-maps-to-enhance-chagas-disease-vector-surveillance
#20
Alexander Gutfraind, Jennifer K Peterson, Erica Billig Rose, Claudia Arevalo-Nieto, Justin Sheen, Gian Franco Condori-Luna, Narender Tankasala, Ricardo Castillo-Neyra, Carlos Condori-Pino, Priyanka Anand, Cesar Naquira-Velarde, Michael Z Levy
BACKGROUND: Until recently, the Chagas disease vector, Triatoma infestans, was widespread in Arequipa, Perú, but as a result of a decades-long campaign in which over 70,000 houses were treated with insecticides, infestation prevalence is now greatly reduced. To monitor for T. infestans resurgence, the city is currently in a surveillance phase in which a sample of houses is selected for inspection each year. Despite extensive data from the control campaign that could be used to inform surveillance, the selection of houses to inspect is often carried out haphazardly or by convenience...
November 29, 2018: PLoS Neglected Tropical Diseases
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