keyword
https://read.qxmd.com/read/38536612/filarial-nematodes-in-dogs-from-the-northeast-region-of-brazil
#1
JOURNAL ARTICLE
Daniely Oliveira do Nascimento Rocha, Lucia Oliveira Macedo, Jéssica Cardoso Pessoa de Oliveira, Samuel Souza Silva, Herbert Patric Kellermann Cleveland, Carlos Alberto do Nascimento Ramos, Alex Santos Marques, Leucio Câmara Alves, Gílcia Aparecida de Carvalho, Rafael Antonio Nascimento Ramos
PURPOSE: Medical and veterinary filarial nematodes are transmitted by blood-feeding vectors. In dogs, these parasites are mainly represented by nematodes in which microfilariae dwell in the blood (Dirofilaria spp. and Acanthocheilonema spp.) or skin (Cercopithifilaria spp. and Onchocerca lupi). The aim of this study was to determine the prevalence of these filarial infections in dogs residing in a touristic, heavily populated location in the northeastern region of Brazil. METHODS: Blood samples (n = 245) were assessed by a modified Knott test, followed by a qualitative ELISA test (SNAP® 4Dx® Plus, IDEXX Laboratory, Westbrook, Maine, USA) for the detection of antibodies against Anaplasma spp...
March 27, 2024: Acta Parasitologica
https://read.qxmd.com/read/38535826/exploration-of-cytochrome-p450-related-interactions-between-aflatoxin-b1-and-tiamulin-in-broiler-chickens
#2
JOURNAL ARTICLE
Pan Sun, Orphélie Lootens, Tadele Kabeta, Diethard Reckelbus, Natalia Furman, Xingyuan Cao, Suxia Zhang, Gunther Antonissen, Siska Croubels, Marthe De Boevre, Sarah De Saeger
Poultry may face simultaneous exposure to aflatoxin B1 (AFB1) and tiamulin (TIA), given mycotoxin contamination and antibiotic use. As both mycotoxins and antibiotics can affect cytochrome P450 enzymes (CYP450), our study aimed to explore their interaction. We developed UHPLC-MS/MS methods for the first-time determination of the interaction between TIA and AFB1 in vitro and in vivo in broiler chickens. The inhibition assay showed the half maximal inhibitory concentration (IC50 ) values of AFB1 and TIA in chicken liver microsomes are more than 7...
March 20, 2024: Toxins
https://read.qxmd.com/read/38535684/rational-design-of-a-portable-chemometric-assisted-voltammetric-sensor-based-on-ion-imprinted-polymeric-film-for-co-ii-determination-in-water
#3
JOURNAL ARTICLE
Sabrina Di Masi, Nelson Arturo Manrique Rodriguez, Marco Costa, Giuseppe Egidio De Benedetto, Cosimino Malitesta
Herein, chemometric-assisted synthesis of electrochemical sensors based on electropolymerised ion-imprinted polymeric (e-IIP) films was explored. Co(II)-IIPs sensors were prepared by performing electropolymerisation procedures of polymerisation mixtures comprising varying concentrations of an electroactive o-aminophenol (o-AP) monomer and Co(II) ions, respectively, according to the Taguchi L9 experimental design, exploiting the simultaneous evaluation of other controlled parameters during electrosynthesis. Each e-IIP developed from Taguchi runs was compared with the respective non-imprinted polymer (NIP) films and fitted according to Langmuir-Freudlich isotherms...
March 18, 2024: Nanomaterials
https://read.qxmd.com/read/38535354/self-recognition-and-allorecognition-mechanisms-exert-a-significant-influence-on-the-sex-allocation-patterns-of-the-pea-aphid
#4
JOURNAL ARTICLE
Yang Li, Shin-Ichi Akimoto, Shi-Yi Jing
The mechanism controlling sex allocation in the pea aphid, Acyrthosiphon pisum (Harris), remains a crucial yet unresolved issue in the field of evolutionary ecology. This study aims to assess the influence of the presence of both self and non-self clones, along with juvenile hormone III (JH III) titer, on the sex allocation of aphid offspring. To this end, red and green clones were utilized as experimental subjects, and the agar method was employed. Initially, three distinct experimental treatments were established using sexuparae, and the daily offspring count and sex allocation in each treatment zone were recorded...
February 27, 2024: Insects
https://read.qxmd.com/read/38534503/determination-of-micromovements-in-removable-prosthesis-during-mastication-a-pilot-study-with-3d-electromagnetic-articulography
#5
JOURNAL ARTICLE
Franco Marinelli, Camila Venegas, Joaquin Victorio Ruiz, Nicole Farfán-Beltrán, Erwin Staub, Pablo Navarro, Josefa Alarcón-Apablaza, Ramón Fuentes
Edentulism can generate negative impacts on self-esteem, interpersonal relationships, and oral functions. Removable prostheses are commonly used for tooth replacement, but they may cause discomfort due to micromovements during mastication. Objective and quantifiable methods are needed to evaluate these micromovements. A pilot study was conducted to determine the micromovements in removable prostheses during mastication using a 3D electromagnetic articulography (EMA-3D) system. One elderly participant wearing lower removable prostheses and an upper total well-fitting removable prosthesis was studied...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38534068/characterization-of-the-in%C3%A2-vivo-transient-responses-of-the-femoral-cartilage-by-means-of-quantitative-ultrasound-imaging-techniques
#6
JOURNAL ARTICLE
Andrea Monte, Martino V Franchi, Paola Zamparo
BACKGROUND: Quantitative ultrasound (QUS) techniques are new diagnostic tools able to identify changes in structural and material properties of the investigated tissue. For the first time, we evaluated the capability of QUS techniques in determining the in vivo transient changes in knee joint cartilage after a stressful task. METHODS: An ultrasound scanner collecting B-mode and radiofrequency data simultaneously was used to collect data from the femoral cartilage of the right knee in 15 participants...
April 2024: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/38532960/-shigella-detection-and-molecular-serotyping-with-a-customized-taqman-array-card-in-the-enterics-for-global-health-efgh-shigella-surveillance-study
#7
JOURNAL ARTICLE
Jie Liu, Paul F Garcia Bardales, Kamrul Islam, Sheikh Jarju, Jane Juma, Chimwemwe Mhango, Queen Naumanga, Sonia Qureshi, Catherine Sonye, Naveed Ahmed, Fatima Aziz, Md Taufiqur Rahman Bhuiyan, Mary Charles, Nigel A Cunliffe, Mahamadou Abdou, Sean R Galagan, Ensa Gitteh, Ibrehima Guindo, M Jahangir Hossain, Abdoulie M J Jabang, Khuzwayo C Jere, Flywell Kawonga, Mariama Keita, Noumou Yakhouba Keita, Karen L Kotloff, Wagner V Shapiama Lopez, Stephen Munga, Maribel Paredes Olortegui, Richard Omore, Patricia B Pavlinac, Firdausi Qadri, Farah Naz Qamar, S M Azadul Alam Raz, Laura Riziki, Francesca Schiaffino, Suzanne Stroup, Sarata Nassoun Traore, Tackeshy Pinedo Vasquez, Mohammad Tahir Yousafzai, Martin Antonio, Jennifer E Cornick, Furqan Kabir, Farhana Khanam, Margaret N Kosek, John Benjamin Ochieng, James A Platts-Mills, Sharon M Tennant, Eric R Houpt
BACKGROUND: Quantitative polymerase chain reaction (qPCR) targeting ipaH has been proven to be highly efficient in detecting Shigella in clinical samples compared to culture-based methods, which underestimate Shigella burden by 2- to 3-fold. qPCR assays have also been developed for Shigella speciation and serotyping, which is critical for both vaccine development and evaluation. METHODS: The Enterics for Global Health (EFGH) Shigella surveillance study will utilize a customized real-time PCR-based TaqMan Array Card (TAC) interrogating 82 targets, for the detection and differentiation of Shigella spp, Shigella sonnei , Shigella flexneri serotypes, other diarrhea-associated enteropathogens, and antimicrobial resistance (AMR) genes...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532920/the-effect-of-iron-supplementation-on-menstrual-bleeding-volume-and-hemoglobin-level-during-menstrual-bleeding-a-randomized-clinical-trial
#8
JOURNAL ARTICLE
Elnaz MokhtarKalimi, Marzeyeh Loripoor, Mohsen Rezaeian, MohammadReza Gholamrezapour
BACKGROUND: Many women around the world avoid taking iron supplements during their menstrual bleeding, thinking that menstrual bleeding will increase after taking these supplements. Due to the lack of relevant scientific evidence in this regard, this study was performed to determine the effect of iron supplementation on menstrual blood volume and hemoglobin level during menstrual bleeding. MATERIALS AND METHODS: In this three-blind randomized clinical trial, 160 non-anemic female students of Rafsanjan University of Medical Sciences were selected through a public call and then they were randomly assigned to two intervention and control groups...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38532368/screening-and-staging-of-chronic-obstructive-pulmonary-disease-with-deep-learning-based-on-chest-x-ray-images-and-clinical-parameters
#9
MULTICENTER STUDY
XiaoLing Zou, Yong Ren, HaiLing Yang, ManMan Zou, Ping Meng, LiYi Zhang, MingJuan Gong, WenWen Ding, LanQing Han, TianTuo Zhang
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is underdiagnosed with the current gold standard measure pulmonary function test (PFT). A more sensitive and simple option for early detection and severity evaluation of COPD could benefit practitioners and patients. METHODS: In this multicenter retrospective study, frontal chest X-ray (CXR) images and related clinical information of 1055 participants were collected and processed. Different deep learning algorithms and transfer learning models were trained to classify COPD based on clinical data and CXR images from 666 subjects, and validated in internal test set based on 284 participants...
March 26, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38532328/tools-to-measure-barriers-to-medication-management-capacity-in-older-adults-a-scoping-review
#10
JOURNAL ARTICLE
Bincy Baby, Annette McKinnon, Kirk Patterson, Hawa Patel, Rishabh Sharma, Caitlin Carter, Ryan Griffin, Catherine Burns, Feng Chang, Sara Jt Guilcher, Linda Lee, Sara Abu Fadaleh, Tejal Patel
BACKGROUND: Medication management capacity is a crucial component of medication adherence, particularly among older adults. Various factors, including physical abilities, cognitive functions, sensory capabilities, motivational, and environmental factors, influence older adults' ability to manage medications. It is, therefore, crucial to identify appropriate tools that allow clinicians to determine which factors may impact medication management capacity and, consequently, nonadherence to medications...
March 27, 2024: BMC Geriatrics
https://read.qxmd.com/read/38531916/simultaneous-impregnation-and-microencapsulation-of-cacl-2-using-silica-gel-and-methyl-cellulose-for-thermal-energy-storage-applications
#11
JOURNAL ARTICLE
Suboohi Shervani, Curtis Strong, F Handan Tezel
Thermal energy storage utilizing the adsorption of moisture from air is a promising energy storage technology due to its high energy density and minimum heat losses. Salt hydrates and salt hydrate composites, such as calcium chloride (CaCl2 ) and CaCl2 -based composites, have shown favourable energy storage properties in this area of research. However, these materials have shown issues with stability due to swelling and deliquescence. In this work, CaCl2 was stabilized using three methods: impregnation into silica gel, encapsulation in methyl cellulose, and both impregnation and encapsulation stabilization techniques used simultaneously...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531816/simultaneous-determination-of-ibrutinib-dihydroxydiol-ibrutinib-and-zanubrutinib-in-human-plasma-by-liquid-chromatography-mass-spectrometry-mass-spectrometry
#12
JOURNAL ARTICLE
Yu-Jiao Guo, Tian-Tian Du, Yan-Ling Yang, Yang Zhao, Xiang-Long Chen, Hong Ma, Lu-Ning Sun, Yong-Qing Wang
BACKGROUND: Ibrutinib and zanubrutinib are Bruton tyrosine kinase inhibitors used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Dihydroxydiol ibrutinib (DHI) is an active metabolite of the drug. A liquid chromatography-tandem mass spectrometry method was developed to detect ibrutinib, DHI, and zanubrutinib in human plasma. METHODS: The method involved a protein precipitation step, followed by chromatographic separation using a gradient of 10 mM ammonium acetate (containing 0...
March 21, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38530236/fast-discrimination-and-quantification-analysis-of-atractylodis-rhizoma-using-nir-spectroscopy-coupled-with-chemometrics-tools
#13
JOURNAL ARTICLE
Le Peng, Mulan He, Xi Wang, Shubo Guo, Yazhong Zhang, Wenlong Li
In this study, near-infrared (NIR) spectroscopy and high-performance liquid chromatography (HPLC) combined with chemometrics tools were applied for quick discrimination and quantitative analysis of different varieties and origins of Atractylodis rhizoma samples. Based on NIR data, orthogonal partial least squares discriminant analysis (OPLS-DA) and K-nearest neighbor (KNN) models achieved greater than 90% discriminant accuracy of the three species and two origins of Atractylodis rhizoma . Moreover, the contents of three active ingredients (atractyloxin, atractylone, and β-eudesmol) in Atractylodis rhizoma were simultaneously determined by HPLC...
March 26, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38530220/pharmacokinetics-and-apparent-michaelis-constant-for-metabolite-conversion-of-sorafenib-in-healthy-and-hepatocellular-carcinoma-bearing-rats
#14
JOURNAL ARTICLE
Hongxin Cai, Xiaoyue Du, Yufeng Deng, Dejian Cao, Lele Wang, Zhiguo Wu, Xianchao Zhang, Jinbiao Xu, Baogang Xie
Aim: Investigation of the pharmacokinetics of sorafenib (SRF) in rats with hepatocellular carcinoma (HCC). Methods: A reproducible ultra-HPLC-MS method for simultaneous determination of serum SRF, N -hydroxymethyl sorafenib and N -demethylation sorafenib. Results: Both the maximum serum concentrations (2.5-times) and the area under the serum concentration-time curve from 0 h to infinity (4.5-times) of SRF were observed to be significantly higher, with a greater than 3.0-fold decrease in the clearance rate in the HCC-bearing rats compared with these values in healthy animals...
March 26, 2024: Bioanalysis
https://read.qxmd.com/read/38529859/-possibilities-of-%C3%A2-therapeutic-retargeting%C3%A2-of-3-hydroxypyridine-and-succinic-acid-derivatives-due-to-their-dopaminergic-action
#15
JOURNAL ARTICLE
I A Volchegorskii, L M Rassokhina, I U Miroshnichenko
The review is devoted to a comparative analysis of the clinical efficacy of the original domestic derivatives of 3-hydroxypyridine and succinic acid (emoxipine, reamberin and mexidol) in comparison with the results of an experimental study of their dopaminergic action. The position that the dopaminomimetic activity of emoxipin, reamberin and mexidol largely determines their anti-ischemic, antihypoxic, insulin-potentiating neuroprotective, nootropic and antidepressant potential has been substantiated. A comparative analysis of the safety profile of emoxipine, reamberin and mexidol was carried out, taking into account potential and real side-effects caused by iatrogenic deviations from the eudopaminergic state...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38529586/characterization-of-nanoparticles-in-mixtures-by-taylor-dispersion-analysis-hyphenated-to-inductively-coupled-plasma-mass-spectrometry
#16
JOURNAL ARTICLE
Daniel Baron, Tomáš Pluháček, Jan Petr
A novel methodology for investigating the behavior of nanoparticles in their mixtures in aqueous high-ionic strength conditions is presented in this work. Our approach utilizes Taylor dispersion analysis in capillaries connected to inductively coupled plasma mass spectrometry (ICP-MS) to probe metal-derived nanoparticles. This methodology simultaneously distinguishes between different kinds of nanoparticles and accurately determines their essential parameters, such as hydrodynamic size, diffusion coefficient, and elemental composition...
March 26, 2024: Analytical Chemistry
https://read.qxmd.com/read/38529487/allele-level-visualization-of-transcription-and-chromatin-by-high-throughput-imaging
#17
Faisal Almansour, Adib Keikhosravi, Gianluca Pegoraro, Tom Misteli
The spatial arrangement of the genome within the nucleus is a pivotal aspect of cellular organization and function with implications for gene expression and regulation. While all genome organization features, such as loops, domains, and radial positioning, are non-random, they are characterized by a high degree of single-cell variability. Imaging approaches are ideally suited to visualize, measure, and study single-cell heterogeneity in genome organization. Here, we describe two methods for the detection of DNA and RNA of individual gene alleles by fluorescence in situ hybridization (FISH) in a high-throughput format...
February 19, 2024: bioRxiv
https://read.qxmd.com/read/38529103/optimizing-androgen-receptor-prioritization-using-high-throughput-assay-based-activity-models
#18
JOURNAL ARTICLE
Ronnie Joe Bever, Stephen W Edwards, Todor Antonijevic, Mark D Nelms, Caroline Ring, Danni Harris, Scott G Lynn, David Williams, Grace Chappell, Rebecca Boyles, Susan Borghoff, Kristan J Markey
Introduction: Computational models using data from high-throughput screening assays have promise for prioritizing and screening chemicals for testing under the U.S. Environmental Protection Agency's Endocrine Disruptor Screening Program (EDSP). The purpose of this work was to demonstrate a data processing method for the determination of optimal minimal assay batteries from a larger comprehensive model, to provide a uniform method of evaluating the performance of future minimal assay batteries compared with the androgen receptor (AR) pathway model, and to incorporate chemical cluster analysis into this evaluation...
2024: Frontiers in toxicology
https://read.qxmd.com/read/38528236/the-effect-of-dose-escalation-radiotherapy-with-simultaneous-integrated-boost-on-the-use-of-short-term-androgen-deprivation-therapy-in-patients-with-intermediate-risk-prostate-cancer
#19
JOURNAL ARTICLE
Cem Onal, Ozan Cem Guler, Gurcan Erbay, Aysenur Elmali
PURPOSE: To compare the biochemical failure (FFBF) and prostate cancer specific survival (PCSS) rates of patients with intermediate-risk prostate cancer (IR-PC) who were treated with 6 months of androgen deprivation therapy (ADT) with 78 Gy to the prostate, those treated with ADT and focal boost (FB) of 86 Gy to intraprostatic lesion (IPL) using the simultaneous-integrated boost (SIB) technique, and those treated with SIB alone. MATERIALS AND METHODS: A retrospective analysis of 320 IR-PC patients treated between January 2012 and April 2021 was performed...
March 25, 2024: Prostate
https://read.qxmd.com/read/38527383/matrix-gla-protein-and-the-long-term-incidence-and-progression-of-coronary-artery-and-aortic-calcification-in-the-multi-ethnic-study-of-atherosclerosis
#20
JOURNAL ARTICLE
Ashley A Berlot, Xueyan Fu, M Kyla Shea, Russell Tracy, Matthew Budoff, Ryung S Kim, Mahim Naveed, Sarah L Booth, Jorge R Kizer, Anna E Bortnick
BACKGROUND AND AIMS: Matrix Gla protein (MGP) is an inhibitor of calcification that requires carboxylation by vitamin K for activity. The inactive form of MGP, dephosphorylated-uncarboxylated matrix Gla protein (dp-ucMGP), has been associated with increased calcification. However, it is not known whether there is a longitudinal relationship between dephosphorylated-uncarboxylated matrix Gla protein levels and coronary and aortic calcification in large population cohorts. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) followed participants with serial cardiac computed tomography (CT) measures of vascular calcification...
March 5, 2024: Atherosclerosis
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