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Simultaneous Determination

Niraj K Sharma, Carlos Pedreira, Umair J Chaudhary, Maria Centeno, David W Carmichael, Tinonkorn Yadee, Teresa Murta, Beate Diehl, Louis Lemieux
OBJECTIVES: Simultaneous intracranial EEG and functional MRI (icEEG-fMRI) can be used to map the haemodynamic (BOLD) changes associated with the generation of IEDs. Unlike scalp EEG-fMRI, in most patients who undergo icEEG-fMRI, IEDs recorded intracranially are numerous and show variability in terms of field amplitude and morphology. Therefore, visual marking can be highly subjective and time consuming. In this study, we applied an automated spike classification algorithm, Wave_clus (WC), to IEDs marked visually on icEEG data acquired during simultaneous fMRI acquisition...
October 10, 2018: NeuroImage
Zachary D Guss, Qinyu Chen, Chen Hu, Lark G Guss, Theodore L DeWeese, Stephanie A Terezakis
PURPOSE/OBJECTIVES: A gender pay gap has been identified in many medical specialties. However, radiation oncology has been excluded from most analyses. This study sought to determine whether such a disparity exists among physicians in United States (US) public academic radiation oncology departments. MATERIALS/METHODS: Radiation oncology physician faculty at US public academic medical schools were identified in states that report public university radiation oncology faculty salary...
October 10, 2018: International Journal of Radiation Oncology, Biology, Physics
Nabil N Al-Hashimi, Rand O Shahin, Aqeel N Al-Hashimi, Ajeal M Al Ajeal, Lubna H Tahtamouni, Chanbasha Basheer
A new cetyl-alcohol-reinforced hollow fiber solid/liquid phase microextraction (CA-HF-SLPME) followed by HPLC-DAD method was developed for simultaneous determination of ezetimibe and simvastatin in human plasma and urine samples. To prepare the CA-HF-SLPME device, the cetyl-alcohol was immobilized into the pores of 2.5 cm hollow fiber micro-tube and the lumen of the micro-tube was filled with 1-octanol with the two ends sealed. Afterward, the prepared device was introduced into 10 mL of the sample solution containing the analytes with agitation...
October 13, 2018: Biomedical Chromatography: BMC
Huimin Hu, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Kexin Liu, Xiaoyu Liu, Huijun Sun
Hyperhomocysteinemia (HHCY) has been recognized as an independent risk factor for atherosclerosis and plays a vital role in the development of atherosclerosis. Catalpol, an iridoid glucoside extracted from the root of Rehmannia glutinosa, can produce anti-inflammatory, anti-oxidant, anti-tumor, and dopaminergic neurons protecting effects. This study aimed to determine the protecting effects of catalpol against homocysteine (HCY)-induced injuries in human aortic endothelial cells (HAECs) and uncover the underlying mechanisms: 1...
October 12, 2018: Inflammation
Jincheng Lin, Mei Huang, Weiqi Yang, Lili Xing
The continuous Ti-Cu compound layer produced in brazing of graphite to copper with Ti foil is found to be seriously detrimental to joint properties due to its brittleness. In this work, a transient liquid phase (TLP) bonding method with a diffusion process below melting point is developed to realize a Ti-Cu compound layer free joint. The degradation of Ti-Cu compound layer depends on two simultaneously occurring processes, namely flow of titanium atoms to copper substrate and that to TiC layer on graphite. The latter is determined by growth kinetics of TiC layer based on carbon diffusion process...
October 12, 2018: Scientific Reports
Linlin Liu, Yingying Li, Guangbiao She, Xianchen Zhang, Brian Jordan, Qi Chen, Jian Zhao, Xiaochun Wan
BACKGROUND: Tea is the most popular nonalcoholic beverage worldwide for its pleasant characteristics and healthful properties. Catechins, theanine and caffeine are the major natural products in tea buds and leaves that determine tea qualities such as infusion colors, tastes and fragrances, as well as their health benefits. Shading is a traditional and effective practice to modify natural product accumulation and to enhance the tea quality in tea plantation. However, the mechanism underlying the shading effects is not fully understood...
October 12, 2018: BMC Plant Biology
Chun-Shuang Guan, Xue-Mei Wang, Zhi-Bin Lv, Shuo Yan, Lei Sun, Ru-Ming Xie
RATIONALE: Kaposi's sarcoma (KS) is the most common malignant tumor in HIV-infected people and occurs mainly in the skin, mucous membranes, and lymph nodes. Approximately 33% of the initial skin manifestations of AIDS and approximately 35% to 79% of KS occur during disease progression. Otherwise, AIDS-related facial KS that was simultaneously examined by magnetic resonance imaging (MRI) is rare. PATIENT CONCERNS: This case was a 30-year-old male homosexual, with left facial nodule for 14 months, and HIV infection was diagnosed 1 month previously...
October 2018: Medicine (Baltimore)
Bahia Abbas Moussa, Marianne Alphonse Mahrouse, Michael Gamal Fawzy
Combination therapy has a pivotal role in type II diabetes mellitus management in patients unable to maintain normal glycemic level using metformin alone. Addition of linagliptin, dipeptidyl peptidase-IV inhibitor, to metformin improves glycemic control. This study is concerned with the development of an HPLC-MS/MS method for simultaneous quantification of linagliptin and metformin in spiked human plasma. The method was applied to evaluate the potential pharmacokinetic interactions between the cited drugs in healthy volunteers...
October 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
Tie Liu, Xiao-Na An, De-Long Liu, Yong-Ju Wei
This work presents a greener approach for simultaneous determination of neomangiferin and mangiferin, the major bioactive constituents with severe spectral overlapping in Anemarrhenae Rhizoma, combining the sensitivity of molecular fluorescence and the selectivity of chemometric multivariate calibration algorithms. In this study, we compared the analytical performance of two group chemometric algorithms including trilinear algorithms such as parallel factor analysis (PARAFAC), alternating trilinear decomposition (ATLD), self-weighted alternating trilinear decomposition (SWATLD) and alternating penalized trilinear decomposition (APTLD), and PLS-based methods such as unfolded partial least-squares or the multi-dimensional partial least-squares, both combined with residual bilinearization (U-PLS/RBL, N-PLS/RBL)...
October 2, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Thomas M Tauris
The prime candidate sources for the upcoming space-borne gravitational wave (GW) observatory LISA are the numerous Galactic tight binaries of white dwarfs (WDs) and neutron stars (NSs), many of which will coalesce and undergo mass transfer, leading to simultaneous emission of x rays and GWs. Here, detailed and coherent numerical stellar models are explored for the formation and evolution of these systems, including finite-temperature effects and complete calculations of mass transfer from a WD to a NS accretor...
September 28, 2018: Physical Review Letters
Mohammad Behbahani, Saman Bagheri, Fariborz Omidi, Mostafa Mohammadpour Amini
The authors described a new application of amino-functionalized KIT-6 for dispersive ultrasonication-assisted micro solid phase extraction of hippuric acid (HA) and methyl hippuric acid (MHA) from human urine and water samples. In the first step, an amino-functionalized mesoporous silica of type KIT-6 was synthesized. It was characterized by field emission scanning electron microscopy, Fourier transform infrared spectrometry, nitrogen adsorption-desorption analysis, thermogravimetry and X-ray diffraction. Following sorption and desorption with 1...
October 11, 2018: Mikrochimica Acta
Chaoqiang Jiang, Dianjun Lu, Chaolong Zu, Jianmin Zhou, Huoyan Wang
It is urgently to minimize nitrogen (N) loss while simultaneously ensuring high yield for maize in China. A two-year field experiment was conducted to determine the effects of root-zone fertilization (RZF) and split-surface broadcasting (SSB) on grain yield, N use efficiency (NUE), and urea-15 N fate under different N rates (135, 180 and 225 kg ha-1 ). Results showed that RZF increased grain yield by 11.5%, and the N derived from fertilizer (Ndff%) by 13.1-19.6%, compared with SSB. The percentage of residual 15 N in the 0-80 cm soil was 37...
October 11, 2018: Scientific Reports
Maurizio Camagna, Alexander Grundmann, Cornelia Bär, Julian Koschmieder, Peter Beyer, Ralf Welsch
Geranylgeranyl diphosphate (GGPP), a prenyl diphosphate synthesized by GGPP synthase (GGPS), represents a metabolic hub for the synthesis of key isoprenoids, such as chlorophylls, tocopherols, phylloquinone, gibberellins, and carotenoids. Protein-protein interactions and the amphipathic nature of GGPP suggest metabolite channeling and/or competition for GGPP among enzymes that function in independent branches of the isoprenoid pathway. To investigate substrate conversion efficiency between the plastid-localized GGPS isoform GGPS11 and phytoene synthase (PSY), the first enzyme of the carotenoid pathway, we used recombinant enzymes and determined their in vitro properties...
October 11, 2018: Plant Physiology
Subrata Biswas, Rahul Mondal, Ayan Mukherjee, Mitali Sarkar, Ramen Kumar Kole
A sensitive gas chromatographic method using a modified QuEChERS technique is reported for simultaneous determination, dissipation and risk assessment of fipronil and its metabolites in sugarcane and soil. Recoveries were 80.7-98.5% with precision within 1.4-16.5% estimated at the limits of detection (LOD) 0.0015-0.002 µg g-1 and limits of quantification (LOQ) 0.005 µg g-1 . Fipronil dissipated with half-life (T1/2 ) of 2.8-4.3 days while for total fipronil it was 3.7-6.0 days following application of fipronil (5% SC) in sugarcane fields at recommended (100 g a...
January 30, 2019: Food Chemistry
Ana Maria de Souza Santos Cheibub, Eduardo Silva Bahiense de Lyra, Annibal Duarte Pereira Netto
A highly sensitive analytical method was developed and validated, following international guidelines, for the determination of the residues of five macrocyclic lactones (MLs) (abamectin, doramectin, eprinomectin, ivermectin and moxidectin) in cheese. The extracts were concentrated by rotary-evaporation and derivatized; no clean-up was necessary. Despite matrix complexity, no significant matrix-effect was verified, and standards were prepared in solvents. Linear working ranges varied from 0.25 to 5.0 μg L-1 ...
January 30, 2019: Food Chemistry
Rita Velez, Tatiana Spitzova, Ester Domenech, Laura Willen, Jordi Cairó, Petr Volf, Montserrat Gállego
BACKGROUND: Canine leishmaniosis (CanL) is an important zoonotic parasitic disease, endemic in the Mediterranean basin. In this region, transmission of Leishmania infantum, the etiological agent of CanL, is through the bite of phlebotomine sand flies. Therefore, monitoring host-vector contact represents an important epidemiological tool, and could be used to assess the effectiveness of vector-control programmes in endemic areas. Previous studies have shown that canine antibodies against the saliva of phlebotomine sand flies are specific markers of exposure to Leishmania vectors...
October 11, 2018: Parasites & Vectors
Christina Bickley, Judith Linton, Elroy Sullivan, Katy Mitchell, Greg Slota, Douglas Barnes
BACKGROUND: Balance testing is an important component in treatment planning and outcome assessment for children with Cerebral Palsy (CP). Objective measurement for static standing balance is typically conducted in motion labs utilizing force plates; however, a plantar pressure mat may prove to be a viable alternative for this type of balance assessment. METHODS: This study examined static standing balance simultaneously on a force plate and a plantar pressure mat in 30 typically developing (TD) and 30 children with CP to determine if valid measures of static standing balance could be obtained in children with CP using a pressure mat...
August 16, 2018: Gait & Posture
Lisa Binder, Johannes Jatschka, Eva Maria Kulovits, Simone Seeböck, Hanspeter Kählig, Claudia Valenta
In the field of dermal drug delivery, determining the penetration depth of actives is a standard procedure for the development of novel formulations. Regarding the vehicle components, respective penetration studies are rather scarce due to their often challenging analytics. However, an understanding of the interactions between drugs and additives during skin penetrating could help to develop promising drug delivery systems. Thus, the objective of the present study was to simultaneously monitor the skin penetration of the incorporated model drug diclofenac sodium and the semifluorinated oil perfluorohexyloctane (F6H8) from newly developed nanoemulsions...
October 8, 2018: International Journal of Pharmaceutics
Jooyong Shim, Changha Hwang
Spatiotemporal nonstationarity and autocorrelation are two crucial points in modeling geographical data. Previous studies have demonstrated that geographically and temporally weighted autoregressive (GTWAR) model accounts for both spatiotemporal nonstationarity and autocorrelation simultaneously to estimate house prices. Therefore, this paper proposes a kernel-based GTWAR (KBGTWAR) model by incorporating the basic principle of support vector machine regression into spatially and temporally varying coefficients model...
2018: PloS One
Suraj Chawla, Anagha Pund, Vibishan B, Shubhankar Kulkarni, Manawa Diwekar-Joshi, Milind Watve
Cross-sectional correlations between two variables have limited implications for causality. We examine here whether it is possible to make causal inferences from steady-state data in a homeostatic system with three or more inter-correlated variables. Every putative pathway between three variables makes a set of differential predictions that can be tested with steady state data. For example, among 3 variables, A, B and C, the coefficient of determination, [Formula: see text] is predicted by the product of [Formula: see text] and [Formula: see text] for some pathways, but not for others...
2018: PloS One
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