keyword
MENU ▼
Read by QxMD icon Read
search

Extraneal

keyword
https://www.readbyqxmd.com/read/28223982/mouse-model-of-neurological-complications-resulting-from-encephalitic-alphavirus-infection
#1
Shannon E Ronca, Jeanon Smith, Takaaki Koma, Magda M Miller, Nadezhda Yun, Kelly T Dineley, Slobodan Paessler
Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. In human survivors, alphavirus encephalitis can cause severe neurobehavioral changes, in the most extreme cases, a schizophrenic-like syndrome. In the present study, we aimed to adapt an animal model of alphavirus infection survival to study the development of these long-term neurological complications. Upon low-dose infection of wild-type C57B/6 mice, asymptomatic and symptomatic groups were established and compared to mock-infected mice to measure general health and baseline neurological function, including the acoustic startle response and prepulse inhibition paradigm...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28179112/glucose-6-phosphate-dehydrogenase-and-trypanothione-reductase-interaction-protects-leishmania-donovani-from-metalloid-mediated-oxidative-stress
#2
Ayan Kumar Ghosh, Savita Saini, Sushmita Das, Abhishek Mandal, Abul Hasan Sardar, Md Yousuf Ansari, Kumar Abhishek, Ajay Kumar, Ruby Singh, Sudha Verma, Asif Equbal, Vahab Ali, Pradeep Das
Exploration of metabolons as viable drug target is rare in kinetoplastid biology. Here we present a novel protein-protein interaction among Glucose-6-phosphate dehydrogenase (LdG6PDH) and Trypanothione reductase (LdTryR) of Leishmania donovani displaying interconnection between central glucose metabolism and thiol metabolism of this parasite. Digitonin fractionation patterns observed through immunoblotting indicated localisation of both LdG6PDH and LdTryR in cytosol. In-silico and in-vitro interaction observed by size exclusion chromatography, co-purification, pull-down assay and spectrofluorimetric analysis revealed LdG6PDH and LdTryR physically interact with each other in a NADPH dependent manner...
February 4, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28164420/an-exploration-of-caregiver-choice-through-the-lens-of-sartrean-existentialism
#3
Kristin L Corey, Mary K McCurry
There are innumerable social and ethical factors which affect one's decision to become an informal caregiver for someone with chronic illness. The existential philosophy of Jean-Paul Sartre provides unique insight into human motivation and choice. The purpose of this paper was to examine the social and ethical influences on the individual's decision to become a caregiver through the lens of Sartrean existentialism and discuss how this unique philosophy can advance nursing knowledge. The factors affecting one's choice to become a caregiver were considered using the Sartrean existential concepts of The Other, human freedom, choice, bad faith, shame and authenticity...
February 6, 2017: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/28152846/cancer-communication-in-the-social-media-age-could-twitter-help-clinical-trial-accrual
#4
Roger B Cohen, Raina M Merchant, Marilyn M Schapira
: 194 Background: Twitter, a social networking site, is transforming communication. Effective use of Twitter might be one way to communicate with the public about cancer clinical trials and increase awareness and perhaps enrollment. We conducted a content analysis of tweets about lung cancer, describing dialogues specific to lung cancer clinical trials and seeing where embedded-links in tweets about therapeutic trials are leading the public. METHODS: We used the Twitter search engine to identify a cohort of 26,059 tweets with the keyword "lung cancer" from January 5 - 21, 2015...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28131745/the-systems-biology-of-auxin-in-developing-embryos
#5
REVIEW
Victoria Mironova, William Teale, Mojgan Shahriari, Jonathan Dawson, Klaus Palme
Systems biology orientates signaling pathways in their biological context. This aim invariably requires models that ignore extraneous factors and focus on the most crucial pathways of any given process. The developing embryo encapsulates many important processes in plant development; understanding their interaction will be key to designing crops able to maximize yield in an ever-more challenging world. Here, we briefly summarize the role of auxin during embryo development. We highlight recent advances in our understanding of auxin signaling and discuss implications for a systems understanding of development...
January 25, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28125388/bias-analysis-for-uncontrolled-confounding-in-the-health-sciences
#6
Onyebuchi A Arah
Uncontrolled confounding due to unmeasured confounders biases causal inference in health science studies using observational and imperfect experimental designs. The adoption of methods for analysis of bias due to uncontrolled confounding has been slow, despite the increasing availability of such methods. Bias analysis for such uncontrolled confounding is most useful in big data studies and systematic reviews to gauge the extent to which extraneous preexposure variables that affect the exposure and the outcome can explain some or all of the reported exposure-outcome associations...
January 6, 2017: Annual Review of Public Health
https://www.readbyqxmd.com/read/28110694/tourette-syndrome-in-the-context-of-evolution-and-behavioral-ecology
#7
Jared Edward Reser
Tourette syndrome, and the closely related spectrum of tic disorders, are inherited neuropsychiatric conditions characterized by the presence of repetitive and stereotyped movements. Tics are elicited by either environmental experiences or internal signals that instruct the basal ganglia to initiate automatic or procedural movements. In most vertebrates the basal ganglia encode instructions for habitually used sequences of motor movements that are essential to survival. Tic disorders may represent evolved phenotypes with a lower threshold for basal ganglia-directed actions...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28095861/challenges-in-conducting-natural-experiments-in-parks-lessons-from-the-revamp-study
#8
Jenny Veitch, Jo Salmon, Billie Giles-Corti, David Crawford, Kate Dullaghan, Alison Carver, Anna Timperio
: Experimental evidence on the role of the built environment for promoting physical activity is important for informing how to create cities that promote active living. Parks provide opportunities for physical activity; however, there is little robust evidence on the impact of park refurbishment. Government agencies often modify parks, providing opportunities for natural experiment studies of these interventions. Such an opportunity was provided by the modification of a large park in Victoria, Australia in 2013 when the Recording and EValuating Activity in a Modified Park (REVAMP) study was established...
January 17, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28095683/colorimetric-detection-of-staphylococcus-aureus-contaminated-solutions-without-purification
#9
Pamela Tiet, Karen C Clark, James O McNamara, Jacob M Berlin
Current water quality monitoring methods rely on growth-based measurements to detect fecal indicator bacteria, such as Escherichia coli and enterococci, and Staphylococcus aureus (S. aureus). These growth-based measurements, however, can take days to complete. This is a significant limitation in the evaluation of contaminated food and water sources. Various methods for selective in vitro detection of S. aureus have also been reported; however, these strategies, such as ELISA, agar-diffusion, PCR, or liquid chromatography-tandem mass spectrometry, all require overnight culturing or sophisticated instrumentation...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28067671/a-fatal-case-of-coin-battery-ingestion-in-an-18-month-old-child-case-report-and-literature-review
#10
Francesco Ventura, Sara Candosin, Rosario Barranco, Alessandro Bonsignore, Luisa Andrello, Luca Tajana, Antonio Osculati
The ingestion of extraneous substances is quite common in clinical practice; it usually befalls in the pediatric age, mostly between 6 months and 6 years. In most cases, complications do not emerge, and the prognosis is considered favorable. However, when a case of battery ingestion occurs, serious adverse events may develop. The ingestion of these components is a potential life-threatening event for children.In this article, we report the case of an 18-month-old child who died from hemorrhagic shock due to an aortoesophageal fistula caused by a 20 mm lithium button battery lodged in the esophagus...
March 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28063585/extraneous-fibre-traces-brought-by-river-water-a-case-study
#11
L Lepot, T Vanden Driessche, K Lunstroot, A Barret, F Gason, K De Wael
The fibre traces on a young victim found underwater were mostly single fibre traces besides small amounts of fibre collectives indistinguishable from his parents clothes (mainly wool). Most of those single fibre traces were blue-grey polyester fibres showing tiny differences among each other. They were unexpected according to known population fibre studies. One year after the victim's discovery experiments were conducted to evaluate the possible contamination with fibres from river water. A small amount of extraneous fibres were collected among which blue and grey-black cotton and man-made (mainly polyester) fibres...
January 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28058411/spontaneous-formation-of-nanometer-scale-tubular-vesicles-in-aqueous-mixtures-of-lipid-and-block-copolymer-amphiphiles
#12
Seng Koon Lim, Andrew S W Wong, Hans-Peter M de Hoog, Padmini Rangamani, Atul N Parikh, Madhavan Nallani, Sara Sandin, Bo Liedberg
Many common amphiphiles self-assemble in water to produce heterogeneous populations of discrete and symmetric but polydisperse and multilamellar vesicles isolating the encapsulated aqueous core from the surrounding bulk. But when mixtures of amphiphiles of vastly different elastic properties co-assemble, their non-uniform molecular organization can stabilize lower symmetries and produce novel shapes. Here, using high resolution electron cryomicroscopy and tomography, we identify the spontaneous formation of a membrane morphology consisting of unilamellar tubular vesicles in dilute aqueous solutions of binary mixtures of two different amphiphiles of vastly different origins...
January 6, 2017: Soft Matter
https://www.readbyqxmd.com/read/28055425/igf1-regulates-runx1-expression-via-irs1-2-implications-for-antler-chondrocyte-differentiation
#13
Zhan-Qing Yang, Hong-Liang Zhang, Cui-Cui Duan, Shuang Geng, Kai Wang, Hai-Fan Yu, Zhan-Peng Yue, Bin Guo
Although IGF1 is important for the proliferation and differentiation of chondrocytes, its underlying molecular mechanism is still unknown. Here we addressed the physiological function of IGF1 in antler cartilage and explored the interplay of IGF1, IRS1/2 and RUNX1 in chondrocyte differentiation. The results showed that IGF1 was highly expressed in antler chondrocytes. Exogenous rIGF1 could increase the proliferation of chondrocytes and cell proportion in the S phase, whereas IGF1R inhibitor PQ401 abrogated the induction by rIGF1...
January 5, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28048625/tu-h-206-02-novel-linearly-filled-derenzo-pet-phantom-design
#14
S Graves, B Cox, M Farhoud, H Valdovinos, J Jeffery, K Eliceiri, T Barnhart, R Nickles
PURPOSE: To design a linearly-filled Derenzo positron emission tomography (PET) phantom, eliminating the extraneous radioisotope volumes in a conventional reservoir-type design. This activity reduction combined with the elimination of bubbles in smaller phantom channels would significantly reduce personnel dose, radioisotope cost, and would improve image quality by reducing out-of-slice activity scatter. METHODS: A computer-aided design (CAD) was created of a modular Derenzo phantom consisting of three phantom layers with gaskets between the layers...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046718/mo-fg-campus-tep1-03-pre-treatment-surface-imaging-based-collision-detection
#15
D Wiant, J Maurer, H Liu, T Hayes, Q Shang, B Sintay
PURPOSE: Modern radiotherapy increasingly employs large immobilization devices, gantry attachments, and couch rotations for treatments. All of which raise the risk of collisions between the patient and the gantry / couch. Collision detection is often achieved by manually checking each couch position in the treatment room and sometimes results in extraneous imaging if collisions are detected after image based setup has begun. In the interest of improving efficiency and avoiding extra imaging, we explore the use of a surface imaging based collision detection model...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035655/automated-target-tracking-in-kilovoltage-images-using-dynamic-templates-of-fiducial-marker-clusters
#16
Warren G Campbell, Moyed Miften, Bernard L Jones
PURPOSE: Implanted fiducial markers are often used in radiotherapy to facilitate accurate visualization and localization of tumors. Typically, such markers are used to aid daily patient positioning and to verify the target's position during treatment. These markers can also provide a wealth of information regarding tumor motion, yet determining their accurate position in thousands of images is often prohibitive. This work introduces a novel, automated method for identifying fiducial markers in planar x-ray imaging...
December 30, 2016: Medical Physics
https://www.readbyqxmd.com/read/28030470/dorsal-root-ganglion-stimulation-yielded-higher-treatment-success-rate-for-crps-and-causalgia-at-3-and-12-months-randomized-comparative-trial
#17
Timothy R Deer, Robert M Levy, Jeffrey Kramer, Lawrence Poree, Kasra Amirdelfan, Eric Grigsby, Peter Staats, Allen W Burton, Abram H Burgher, Jon Obray, James Scowcroft, Stan Golovac, Leonardo Kapural, Richard Paicius, Christopher Kim, Jason Pope, Thomas Yearwood, Sam Samuel, W Porter McRoberts, Hazmer Cassim, Mark Netherton, Nathan Miller, Michael Schaufele, Edward Tavel, Timothy Davis, Kristina Davis, Linda Johnson, Nagy Mekhail
Animal and human studies indicate that electrical stimulation of DRG neurons may modulate neuropathic pain signals.ACCURATE, a pivotal, prospective, multi-center, randomized-comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome (CRPS) or causalgia in the lower extremities. Subjects received neurostimulation of the DRG or dorsal column (SCS). The primary endpoint was a composite of safety and efficacy at 3 months and subjects were assessed through 12 months for long term outcomes and adverse events...
December 23, 2016: Pain
https://www.readbyqxmd.com/read/28018018/mutual-influences-between-parental-psychological-distress-and-alcohol-use-and-child-problem-behavior-in-a-cohort-of-urban-african-americans
#18
Katarzyna A Zebrak, Kerry M Green
Parental psychological distress, parental alcohol involvement, and child/adolescent behavior problems frequently occur together with deleterious effects on individuals and families. Extant evidence suggests that parental and child problems are related; however, less is known about the patterns and directions of their relationships over time, particularly among African Americans. This study examined mutual influences between parental psychological distress and alcohol use, and child/adolescent problem behavior over a 10-year period (N = 459), using data from a prospective cohort study of urban African Americans...
October 2016: Journal of Family Issues
https://www.readbyqxmd.com/read/28001420/modifying-the-interface-edge-to-control-the-electrical-transport-properties-of-nanocontacts-to-nanowires
#19
Alex M Lord, Quentin M Ramasse, Despoina M Kepaptsoglou, Jonathan E Evans, Philip R Davies, Michael B Ward, Steve P Wilks
Selecting the electrical properties of nanomaterials is essential if their potential as manufacturable devices is to be reached. Here, we show that the addition or removal of native semiconductor material at the edge of a nanocontact can be used to determine the electrical transport properties of metal-nanowire interfaces. While the transport properties of as-grown Au nanocatalyst contacts to semiconductor nanowires are well-studied, there are few techniques that have been explored to modify the electrical behavior...
January 3, 2017: Nano Letters
https://www.readbyqxmd.com/read/27924730/congenital-malformations-attributed-to-prenatal-exposure-to-cyclophosphamide
#20
Padmanabhan Rengasamy
Cyclophosphamide (CPA) remains one of the most widely prescribed anticancer drugs. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and systemic lupus erythematosus. It is a potent immunosuppressive agent. It is commonly used in blood and bone marrow transplantation. With the growing trend among women postponing childbearing, the number of women who are diagnosed with breast cancer is also increasing thus escalating the chances of exposure of the unborn child to antineoplastic drugs...
December 6, 2016: Anti-cancer Agents in Medicinal Chemistry
keyword
keyword
15972
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"