keyword
https://read.qxmd.com/read/38491259/cytotoxicity-of-laser-synthesized-nanoparticles-of-elemental-bismuth
#1
JOURNAL ARTICLE
P V Shakhov, G V Tikhonowski, A A Popov, A R Iliasov, D S Petrunya, A A Lebedev, S M Klimentov, I N Zavestovskaya, A V Kabashin
High X-ray absorption combined with photothermal properties make bismuth nanoparticles (Bi NP) a promising agent for multimodal cancer theranostics. However, the synthesis of Bi NP by the "classical" chemical methods has numerous limitations, including potential toxicity of the produced nanomaterials. Here we studied in vitro toxicity of laser-synthesized Bi NP coated with Pluronic F-127 on mouse fibroblast cell line L929. The survival of L929 cells decreased linearly with increasing the concentration of Bi NP in a concentration range of 3-500 μg/ml; the LC50 value was 57 μg/ml...
March 16, 2024: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/38479563/synthesis-of-folate-targeted-theranostic-cubosomal-platform-for-co-delivery-of-bismuth-oxide-and-doxorubicin-to-melanoma-in-vitro-and-in-vivo
#2
JOURNAL ARTICLE
Mahsa Zahiri, Hosein Kamali, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Negar Nekooei, Mohammad Ramezani, Mona Alibolandi
Liquid crystalline nanoparticles (LCNPs) have gained much attention in cancer nanomedicines due to their unique features such as high surface area, storage stability, and sustained-release profile. In the current study, a novel LCNP for co-encapsulation of Bi2 O3 and hydrophilic doxorubicin (DOX) was fabricated and functionalized with folic acid (FA) to achieve efficient tumor targeting toward CT-scan imaging and chemotherapy of melanoma in vitro and in vivo. LCNPs Bi2 O3 NPs were prepared using glycerol monooleate-pluronic F-127 (GMO/PF127/water)...
March 11, 2024: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/38462835/a-snapshot-of-selenium-enclosed-nanoparticles-for-the-management-of-cancer
#3
JOURNAL ARTICLE
Rohitas Deshmukh, Rajesh Singh, Sandeep Sharma, Ashwini Kumar Mishra, Ranjit K Harwansh
Among the primary causes of mortality in today's world is cancer. Many drugs are employed to give lengthy and severe chemotherapy and radiation therapy, like nitrosoureas (Cisplatin, Oxaliplatin), Antimetabolites (5-fluorouracil, Methotrexate), Topoisomerase inhibitors (Etoposide), Mitotic inhibitors (Doxorubicin); such treatment is associated with significant adverse effects. Antitumor antibiotics have side effects similar to chemotherapy and radiotherapy. Selenium (Se) is an essential trace element for humans and animals, and additional Se supplementation is required, particularly for individuals deficient in Se...
March 7, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38425095/antimicrobial-potential-of-a-biosurfactant-gel-for-the-prevention-of-mixed-biofilms-formed-by-fluconazole-resistant-c-albicans-and-methicillin-resistant-s-aureus-in-catheters
#4
JOURNAL ARTICLE
Cecília Rocha da Silva, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Fátima Daiana Dias Barroso, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Lisandra Juvêncio da Silva, Iri Sandro Pampolha Lima, Lourdes Pérez, Anderson Ramos da Silva, Denise Ramos Moreira, Nágila Maria Pontes Silva Ricardo, Hélio Vitoriano Nobre
Dual-species biofilms formed by Candida albicans and Staphylococcus aureus have high virulence and drug resistance. In this context, biosurfactants produced by Pseudomonas aeruginosa have been widely studied, of which a new derivative (RLmix_Arg) stands out for possible application in formulations. The objective of this study was to evaluate the antibiofilm activity of RLmix_Arg, both alone and incorporated in a gel prepared with Pluronic F-127, against dual-species biofilms of fluconazole-resistant C. albicans (FRCA) and methicillin-resistant S...
February 29, 2024: Biofouling
https://read.qxmd.com/read/38422929/excimer-emission-from-polycyclic-arenes-bearing-triphenylmethyl-group-solid-state-fluorescence-mechanofluorochromism-aggregation-induced-emission-and-cell-imaging-application
#5
JOURNAL ARTICLE
Yongling Zheng, Panpan Chen, Zhigang Niu, Enju Wang
The excimer emission based on discrete π-stacked dimers of polycyclic π-systems has generated significant interest in the structure-luminescence relationship of excimers owing to their ultra-large Stokes shift. Herein, a series of excimer emissive luminogens were obtained by conjugating different polycyclic aromatic aldehydes (anthraldehyde, pyrenealdehyde and perylenealdehyde) with triphenylmethylamine. In crystalline states, all the molecules were arranged in the form of π-stacked arene dimers which were spatially isolated from each other by the bulky triphenylmethyl groups, and thus emitted bright excimer emission...
February 12, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38422400/digital-light-processing-4d-printing-of-poloxamer-micelles-for-facile-fabrication-of-multifunctional-biocompatible-hydrogels-as-tailored-wearable-sensors
#6
JOURNAL ARTICLE
Wen Shi, Seonmin Jang, Mitchell A Kuss, Olawale A Alimi, Bo Liu, Jayden Palik, Li Tan, Mena Asha Krishnan, Yifei Jin, Cunjiang Yu, Bin Duan
The lack of both digital light processing (DLP) compatible and biocompatible photopolymers, along with inappropriate material properties required for wearable sensor applications, substantially hinders the employment of DLP 3D printing in the fabrication of multifunctional hydrogels. Herein, we discovered and implemented a photoreactive poloxamer derivative, Pluronic F-127 diacrylate, which overcomes these limitations and is optimized to achieve DLP 3D printed micelle-based hydrogels with high structural complexity, resolution, and precision...
February 29, 2024: ACS Nano
https://read.qxmd.com/read/38417214/modulation-of-macrophages-by-a-phillyrin-loaded-thermosensitive-hydrogel-promotes-skin-wound-healing-in-mice
#7
JOURNAL ARTICLE
Chenggang Huang, Jiajia Teng, Wei Liu, Junzhe Wang, An Liu
BACKGROUND: Impaired wound healing in traumatic skin injuries remains a severe clinical challenge due to impaired re-vascularization, harmful bacteria infection, and inflammation dysregulation. Macrophages are recognized as prominent immune cells in tissue regeneration and wound healing. Consequently, the modulation of macrophages provides a promising therapeutic target for wound healing disorders. Here, we aimed to explore whether a novel constructed combination of thermosensitive hydrogel Pluronic F-127 (PF-127) and phillyrin (PH, the main active compound of forsythia suspensa) could improve skin wound healing...
February 27, 2024: Cytokine
https://read.qxmd.com/read/38413775/spray-dried-ph-sensitive-chitosan-microparticles-loaded-with-mycobacterium-bovis-bcg-intended-for-supporting-treatment-of-helicobacter-pylori-infection
#8
JOURNAL ARTICLE
Weronika Gonciarz, Marek Brzeziński, Weronika Orłowska, Paweł Wawrzyniak, Artur Lewandowski, Vedha Hari B Narayanan, Magdalena Chmiela
Gram-negative spiral-shaped Helicobacter pylori (Hp) bacteria induce the development of different gastric disorders. The growing resistance of Hp to antibiotics prompts to search for new therapeutic formulations. A promising candidate is Mycobacterium bovis BCG (BCG) with immunomodulatory properties. Biodegradable mucoadhesive chitosan is a good carrier for delivering BCG mycobacteria to the gastric mucosal environment. This study aimed to show whether BCG bacilli are able to increase the phagocytic activity of Cavia porcellus-guinea pig macrophages derived from the bone marrow towards fluorescently labeled Escherichia coli...
February 27, 2024: Scientific Reports
https://read.qxmd.com/read/38395289/an-injectable-thermosensitive-hyaluronic-acid-pluronic-f-127-hydrogel-for-deep-penetration-and-combination-therapy-of-frozen-shoulder
#9
JOURNAL ARTICLE
Jucong Zhang, Yanling Song, Luwen Zhu, Yuchan You, Jiahao Hu, Xinyi Xu, Chen Wang, Jingyi Lu, Qiying Shen, Xiaoling Xu, Chong Teng, Yongzhong Du
Frozen shoulder (FS) is a common and progressive shoulder disorder that causes glenohumeral joint stiffness, characterized by inflammation and fibrosis. The treatment options are quite limited, and the therapeutic response is hindered by the fibrous membrane formed by excessive collagen and the rapid removal by synovial fluid. To address these challenges, we designed a hyaluronic acid/Pluronic F-127 (HP)-based injectable thermosensitive hydrogel as a drug carrier loaded with dexamethasone and collagenase (HPDC)...
February 21, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38346857/modulation-of-heterotypic-and-homotypic-interactions-to-visualize-the-evolution-of-organic-aggregates-in-a-fluorescence-turn-on-manner
#10
JOURNAL ARTICLE
Changhuo Xu, Xinwen Ou, Bingzhe Wang, Hanchen Shen, Junkai Liu, Xueqin Yang, Qingqing Zhou, Joe H C Chau, Herman H Y Sung, Guichuan Xing, Jacky W Y Lam, Ben Zhong Tang
The abnormal evolution of membrane-less organelles into amyloid fibrils is a causative factor in many neurodegenerative diseases. Fundamental research on evolving organic aggregates is thus instructive for understanding the root causes of these diseases. In-situ monitoring of evolving molecular aggregates with built-in fluorescence properties is a reliable approach to reflect their subtle structural variation. To increase the sensitivity of real-time monitoring, we presented organic aggregates assembled by TPAN-2MeO, which is a triphenyl acrylonitrile derivative...
February 12, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38332511/temperature-sensitive-hydrogel-releasing-pectolinarin-facilitate-scarless-wound-healing
#11
JOURNAL ARTICLE
Xiaohang Chen, Haoyue Song, Kun Song, Yuan Zhang, Jia Wang, Jinjia Hong, Qingpeng Xie, Jing Zhao, Meixian Liu, Xing Wang
The dressing that promotes scarless healing is essential for both normal function and aesthetics after a wound. With a deeper understanding of the mechanisms involved in scar formation during the wound healing process, the ideal dressing becomes clearer and more promising. For instance, the yes-associated transcriptional regulator (YAP) has been extensively studied as a key gene involved in regulating scar formation. However, there has been limited attention given to pectolinarin, a natural flavonoid that may exhibit strong binding affinity to YAP, in the context of scarless healing...
February 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38306853/effect-of-anti-adhesive-supplement-doses-on-sperm-motility-characteristics-in-the-european-whitefish-coregonus-lavaretus
#12
JOURNAL ARTICLE
Beata Irena Cejko, Dorota Fopp-Bayat, Roman Kujawa
Sperm adhering to glass slides is one of the main problems during fish sperm motility analyses with CASA systems. To mitigate this, albumin is the supplement added most frequently to activating solutions. However, there is no data on the use of supplements other than albumin (in various concentrations) in analyses of European whitefish (Coregonus lavaretus) sperm motility. This issue was investigated in the presented research using three anti-adhesive supplements (albumin, casein, Pluronic F-127) that were added to Billard solution (BS: 20 mM Tris, 1 mM CaCl2 , 154 mM NaCl, 30 mM glycine at pH 9...
January 28, 2024: Animal Reproduction Science
https://read.qxmd.com/read/38305576/injectable-and-self-healable-nano-architectured-hydrogel-for-nir-light-responsive-chemo-and-photothermal-bacterial-eradication
#13
JOURNAL ARTICLE
Daniel Rybak, Chiara Rinoldi, Paweł Nakielski, Jingtao Du, Mohammad Ali Haghighat Bayan, Seyed Shahrooz Zargarian, Michał Pruchniewski, Xiaoran Li, Barbara Strojny-Cieślak, Bin Ding, Filippo Pierini
Hydrogels with multifunctional properties activated at specific times have gained significant attention in the biomedical field. As bacterial infections can cause severe complications that negatively impact wound repair, herein, we present the development of a stimuli-responsive, injectable, and in situ -forming hydrogel with antibacterial, self-healing, and drug-delivery properties. In this study, we prepared a Pluronic F-127 (PF127) and sodium alginate (SA)-based hydrogel that can be targeted to a specific tissue via injection...
February 2, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38253516/additive-manufacturing-of-iron-carbide-incorporated-bioactive-glass-scaffolds-for-bone-tissue-engineering-and-drug-delivery-applications
#14
JOURNAL ARTICLE
Ashok Vishwakarma, Niraj Sinha
In this study, we have synthesized a bioactive glass with composition 45SiO2 -20Na2 O-23CaO-6P2 O5 -2.5B2 O3 -1ZnO-2MgO-0.5CaF2 (wt %). Further, it has been incorporated with 0.4 wt % iron carbide nanoparticles to prepare magnetic bioactive glass (MBG) with good heat generation capability for potential applications in magnetic field-assisted hyperthermia. The MBG scaffolds have been fabricated using extrusion-based additive manufacturing by mixing MBG powder with 25% Pluronic F-127 solution as the binder. The saturation magnetization of iron carbide nanoparticles in the bioactive glass matrix has been found to be 80 emu/g...
January 22, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38247759/-acanthus-mollis-formulations-for-transdermal-delivery-from-hydrogels-to-emulsions
#15
JOURNAL ARTICLE
Patrícia Matos, Maria Teresa Batista, Francisco Veiga, Artur Figueirinha, Ana Figueiras
Topical formulations of Acanthus mollis L. leaf and the optimization of the release of their active compounds and their topical bioavailability were investigated for the first time. In vitro, the release of active compounds from three formulations-an oil-in-water cream and two hydrogels (Carbopol 940 and Pluronic F-127)-was determined using Franz diffusion cells. Detection and quantification of the compounds was performed via high-performance liquid chromatography with a photodiode array (HPLC-PDA). DIBOA, a bioactive compound of this medicinal plant, exhibited release kinetics of the Weibull model for the Carbopol and Pluronic F-127 formulation, identifying it as a potential active agent to optimize the topical distribution of the formulations...
December 31, 2023: Gels
https://read.qxmd.com/read/38193246/preparation-and-in%C3%A2-vitro-evaluation-of-protective-effects-of-silibinin-loaded-polymeric-micelles-on-human-hair-against-uv-b-radiation
#16
JOURNAL ARTICLE
Behzad Sharif Makhmal Zadeh, Hamed Akbari, Anayatollah Salimi
BACKGROUND: The purpose of this study was to investigate the protective effect of Silibinin-loaded polymeric micelles from human hair against UV-B radiation. METHODS: Eight formulations with different concentrations of Silibinin, Pluronic F-127, and Labrasol-Labrafil were made by a solvent evaporation method, and the selected formulation was chosen by examining their properties like particle size and loading efficiency. Six groups of human hair, including a group that received the selected formulation, were exposed to UV-B radiation and by calculating its factors such as peak-to-valley roughness, RMS roughness, FTIR, and the amount of protein loss, the protective effect of the selected formulation was judged...
January 9, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38189962/lysosome-targeted-ruthenium-ii-complex-encapsulated-with-pluronic-%C3%A2-f-127-induces-oncosis-in-a549-cells
#17
JOURNAL ARTICLE
Nanlian Pan, Yuqing Zhang, Minying Huang, Zhijun Liang, Yao Gong, Xide Chen, Yuling Li, Ciling Wu, Zunnan Huang, Jing Sun
Transition metal complexes with characteristics of unique packaging in nanoparticles and remarkable cancer cell cytotoxicity have emerged as potential alternatives to platinum-based antitumor drugs. Here we report the synthesis, characterization, and antitumor activities of three new Ruthenium complexes that introduce 5-fluorouracil-derived ligands. Notably, encapsulation of one such metal complex, Ru3, within pluronic® F-127 micelles (Ru3-M) significantly enhanced Ru3 cytotoxicity toward A549 cells by a factor of four...
January 8, 2024: Journal of Biological Inorganic Chemistry: JBIC
https://read.qxmd.com/read/38175336/flash-nanoprecipitation-allows-easy-fabrication-of-ph-responsive-acetalated-dextran-nanoparticles-for-intracellular-release-of-payloads
#18
JOURNAL ARTICLE
Krystal A Hughes, Bishal Misra, Maryam Maghareh, Parinya Samart, Ethan Nguyen, Salik Hussain, Werner J Geldenhuys, Sharan Bobbala
Acetalated dextran (Ac-Dex) nanoparticles are currently of immense interest due to their sharp pH-responsive nature and high biodegradability. Ac-Dex nanoparticles are often formulated through single- or double-emulsion methods utilizing polyvinyl alcohol as the stabilizer. The emulsion methods utilize toxic organic solvents such as dichloromethane or chloroform and require multi-step processing to form stable Ac-Dex nanoparticles. Here, we introduce a simple flash nanoprecipitation (FNP) approach that utilizes a confined impinging jet mixer and a non-toxic solvent, ethanol, to form Ac-Dex nanoparticles rapidly...
January 4, 2024: Discov Nano
https://read.qxmd.com/read/38162046/lignin-derived-mesoporous-carbon-for-sodium-ion-batteries-block-copolymer-soft-templating-and-carbon-microstructure-analysis
#19
JOURNAL ARTICLE
Chantal Glatthaar, Mengnan Wang, Lysander Q Wagner, Frederik Breckwoldt, Zhenyu Guo, Kaitian Zheng, Manfred Kriechbaum, Heinz Amenitsch, Maria-Magdalena Titirici, Bernd M Smarsly
The demand for versatile and sustainable energy materials is on the rise, given the importance of developing novel clean technologies for transition to a net zero economy. Here, we present the synthesis, characterization, and application of lignin-derived ordered mesoporous carbons with various pore sizes (from 5 to approximately 50 nm) as anodes in sodium-ion batteries. We have varied the pore size using self-synthesized PEO n - b -PHA m block copolymers with different PEO and PHA chain lengths, applying the "soft templating" approach to introduce isolated spherical pores of 20 to 50 nm in diameters...
December 26, 2023: Chemistry of Materials: a Publication of the American Chemical Society
https://read.qxmd.com/read/38142949/formulation-optimization-and-evaluation-of-oromucosal-in-situ-gel-loaded-with-silver-nanoparticles-prepared-by-green-biosynthesis
#20
JOURNAL ARTICLE
Simona Rohaľová, Tomáš Wolaschka, Ľudmila Balážová, Katarína Paulovičová, Jana Tóthová, Sylvie Pavloková, Martin Stahorský, Jan Gajdziok
Treating oral diseases remains challenging as API is quickly washed out of the application site by saliva turnover and mouth movements. In situ gels are a class of application forms that present sol-gel transition's ability as a response to stimuli. Their tunable properties are provided using smart polymers responsible for stimuli sensitivity, often providing mucoadhesivity. In this study, antimicrobial in situ gels of thermosensitive and pH-sensitive polymers loaded with silver nanoparticles were prepared and evaluated...
December 22, 2023: European Journal of Pharmaceutical Sciences
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