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https://www.readbyqxmd.com/read/30315306/grading-of-atrophic-gastritis-is-useful-for-risk-stratification-in-endoscopic-screening-for-gastric-cancer
#1
Kyosuke Kaji, Atsushi Hashiba, Chika Uotani, Yasushi Yamaguchi, Toshio Ueno, Kenji Ohno, Ichiro Takabatake, Tokio Wakabayashi, Hisashi Doyama, Itasu Ninomiya, Masato Kiriyama, Shigekazu Ohyama, Manabu Yoneshima, Nobu Koyama, Yasuo Takeda, Kenji Yasuda
OBJECTIVES: In order to screen for gastric cancer effectively, its interval should be set according to the risk. This study aimed to determine whether risk stratification is possible using the data obtained from medical examination or endoscopic findings. METHODS: First, subjects who underwent both cancer screening and medical examination from 2009 to 2015 and underwent cancer screening once more by 2016 were studied. Data such as the lipid profile and history of smoking obtained during the medical examination, and the grade of atrophy and presence of peptic ulcers were studied using multivariate analysis...
October 12, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/30281619/antibacterial-effects-of-nano-imprinted-moth-eye-film-in-practical-settings
#2
Miho Yamada, Kiyoshi Minoura, Takashi Mizoguchi, Kenichiro Nakamatsu, Tokio Taguchi, Takuya Kameda, Miho Sekiguchi, Tatsuo Suzutani, Shinichi Konno
BACKGROUND: Recent studies report that surfaces displaying micrometer- or nanometer-sized undulating structures exhibit antibacterial effects. In previous work, we described the use of an advanced nanofabrication technique to generate an artificial biomimetic Moth-eye film by coating a polyethylene terephthalate (PET) film with nanoscale moth-eye protrusions made from a hydrophilic resin. This moth-eye film exhibited enhanced antibacterial effects in in vitro experiments. The aim of the present study was to verify the antibacterial efficacy of the Moth-eye film in practical environments...
2018: PloS One
https://www.readbyqxmd.com/read/30128386/successful-eus-guided-retrograde-pancreatic-duct-stent-placement-for-refractory-pancreaticojejunostomy-stricture-after-pancreaticoduodenectomy-with-a-forward-viewing-echoendoscope
#3
Yuji Hodo, Yukihiro Shirota, Tsuyoshi Suda, Tokio Wakabayashi
No abstract text is available yet for this article.
June 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/30045302/autoimmune-hepatitis-following-influenza-virus-vaccination-two-case-reports
#4
Tokio Sasaki, Yuji Suzuki, Kazuyuki Ishida, Keisuke Kakisaka, Hiroaki Abe, Tamotsu Sugai, Yasuhiro Takikawa
RATIONALE: Although immunization could possibly cause autoimmune hepatitis (AIH), to date, no cases of AIH have been reported secondary to influenza virus vaccination. This paper describes 2 women who developed AIH after receiving influenza virus vaccination. PATIENT CONCERNS AND DIAGNOSES: Two women presented with elevation of liver enzymes after receiving influenza virus vaccination. Both patients were diagnosed with AIH using the International Autoimmune Hepatitis Group criteria...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29963746/foxo-are-required-for-intervertebral-disk-homeostasis-during-aging-and-their-deficiency-promotes-disk-degeneration
#5
Oscar Alvarez-Garcia, Tokio Matsuzaki, Merissa Olmer, Kohei Miyata, Sho Mokuda, Daisuke Sakai, Koichi Masuda, Hiroshi Asahara, Martin K Lotz
Intervertebral disk (IVD) degeneration is a prevalent age-associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis during aging are unknown. The aim of this study was to investigate the function of FOXO, a family of transcription factors linked to aging and longevity, in IVD aging and age-related degeneration. Conditional deletion of all FOXO isoforms (FOXO1, 3, and 4) in IVD using the Col2a1Cre and AcanCreER mouse resulted in spontaneous development of IVD degeneration that was driven by severe cell loss in the nucleus pulposus (NP) and cartilaginous endplates (EP)...
October 2018: Aging Cell
https://www.readbyqxmd.com/read/29778913/pneumatosis-cystoides-intestinalis
#6
Tsuyoshi Suda, Yukihiro Shirota, Tokio Wakabayashi
No abstract text is available yet for this article.
May 17, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29775826/atypical-virulence-in-a-type-iii-toxoplasma-gondii-strain-isolated-in-japan
#7
Yuji Taniguchi, Cornelia Appiah-Kwarteng, Mami Murakami, Junpei Fukumoto, Kisaburo Nagamune, Tomohide Matsuo, Tatsunori Masatani, Hirotaka Kanuka, Tokio Hoshina, Katsuya Kitoh, Yasuhiro Takashima
The virulence of a type III Toxoplasma gondii strain isolated in Japan and designated here as TgCatJpGi1/TaJ was examined in mice and micro minipigs in this study. Despite its type III genotype, oral or intraperitoneal inoculation of cysts from it resulted in severe virulence in C57BL/6J and BALB/c mice. In contrast, mice inoculated with a high dose of TgCatJpGi1/TaJ tachyzoites showed no obvious clinical signs of infection, and all of them survived for >21 days post-inoculation. Furthermore, no clinical signs of infection were seen when micro minipigs were inoculated with 900 cysts...
May 22, 2018: Parasitology International
https://www.readbyqxmd.com/read/29553105/arterial-infusion-of-cisplatin-plus-s-1-against-unresectable-intrahepatic-cholangiocarcinoma
#8
Tokio Higaki, Osamu Aramaki, Masamichi Moriguchi, Hisashi Nakayama, Yutaka Midorikawa, Tadatoshi Takayama
Conventional regimens for unresectable intrahepatic cholangiocarcinoma are considered of limited effectiveness. To evaluate the efficacy and toxicity of combination chemotherapy with hepatic arterial infusion of IA-call (a fine-powder formulation of cisplatin) plus oral S-1 in patients with unresectable intrahepatic cholangiocarcinoma. The clinicopathological data and long-term outcome of 12 patients who were received with IA-call plus S-1 were compared with those of 16 patients who were received other treatments, such as radiation therapy, trans-arterial chemoembolization, and systemic chemotherapy...
2018: Bioscience Trends
https://www.readbyqxmd.com/read/29553104/neither-ischemic-parenchymal-volume-nor-severe-grade-complication-correlate-transient-high-transaminase-elevation-after-liver-resection
#9
Tokio Higaki, Shintaro Yamazaki, Yusuke Mitsuka, Masaru Aoki, Nao Yoshida, Yutaka Midorikawa, Hisashi Nakayama, Tadatoshi Takayama
To clarify whether high transient elevation of serum transaminase predicts severe complications and is related to the ischemic area on CT. Postoperative laboratory data and ischemia area on CT were analyzed on the basis of the presence of high transaminase elevation (aspartate aminotransferase (AST) > 1,000 IU/L within postoperative day (POD) 2 after liver resection. In the high elevation group, volume of ischemic areas was assessed by CT on POD2. The 538 patients were divided into a high transaminase group (n = 51) and a control group (n = 487)...
2018: Bioscience Trends
https://www.readbyqxmd.com/read/29499989/clinical-pathologic-and-genetic-features-of-neonatal-dubin-johnson-syndrome-a-multicenter-study-in-japan
#10
Takao Togawa, Tatsuki Mizuochi, Tokio Sugiura, Hironori Kusano, Ken Tanikawa, Takato Sasaki, Fumio Ichinose, Seiichi Kagimoto, Takahisa Tainaka, Hiroo Uchida, Shinji Saitoh
OBJECTIVE: To clarify the clinical, pathologic, and genetic features of neonatal Dubin-Johnson syndrome. STUDY DESIGN: Ten patients with neonatal Dubin-Johnson syndrome were recruited from 6 pediatric centers in Japan between September 2013 and October 2016. Clinical and laboratory course, macroscopic and microscopic liver findings, and molecular genetic findings concerning ATP-binding cassette subfamily C member 2 (ABCC2) were retrospectively and prospectively examined...
May 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29475614/ventral-approach-for-resecting-hepatocellular-carcinoma-in-the-caval-portion-of-the-caudate-lobe
#11
Tokio Higaki, Tadatoshi Takayama, Yutaka Midorikawa
BACKGROUND: Resection of hepatocellular carcinoma located in the caudate lobe is challenging because this anatomical location is difficult to approach, especially the caval portion. METHODS: We performed resection of the caval portion of the caudate lobe using a ventral approach combined with the resection of segment IV, VII, or VIII for hepatocellular carcinoma in 41 patients (extended segmentectomy group). As a control group, 138 patients with hepatocellular carcinoma who underwent segmentectomy for IV, VII, or VIII (segmentectomy group) were studied...
June 2018: Surgery
https://www.readbyqxmd.com/read/29452700/liver-resection-for-recurrent-hepatocellular-carcinoma-to-improve-survivability-a-proposal-of-indication-criteria
#12
Rempei Yagi, Yutaka Midorikawa, Masamichi Moriguchi, Hisashi Nakayama, Osamu Aramaki, Shintaro Yamazaki, Tokio Higaki, Tadatoshi Takayama
BACKGROUND: Despite curative resection of hepatocellular carcinoma, patients have a high probability of recurrence. We examined indications for liver resection in cases of recurrent hepatocellular carcinoma. METHODS: Patients undergoing a second liver resection (n=210) or treatment by transcatheter arterial chemoembolization (n=184) for recurrent hepatocellular carcinoma of up to 3 lesions were included. We developed a prediction score based on prognostic factors and compared survival according to this prediction score...
June 2018: Surgery
https://www.readbyqxmd.com/read/29444976/foxo-transcription-factors-modulate-autophagy-and-proteoglycan-4-in-cartilage-homeostasis-and-osteoarthritis
#13
Tokio Matsuzaki, Oscar Alvarez-Garcia, Sho Mokuda, Keita Nagira, Merissa Olmer, Ramya Gamini, Kohei Miyata, Yukio Akasaki, Andrew I Su, Hiroshi Asahara, Martin K Lotz
Aging is a main risk factor for osteoarthritis (OA). FoxO transcription factors protect against cellular and organismal aging, and FoxO expression in cartilage is reduced with aging and in OA. To investigate the role of FoxO in cartilage, Col2Cre-FoxO1, 3, and 4 single knockout (KO) and triple KO mice (Col2Cre-TKO) were analyzed. Articular cartilage in Col2Cre-TKO and Col2Cre-FoxO1 KO mice was thicker than in control mice at 1 or 2 months of age. This was associated with increased proliferation of chondrocytes of Col2Cre-TKO mice in vivo and in vitro...
February 14, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29423605/an-international-clinical-study-of-ability-and-disability-in-autism-spectrum-disorder-using-the-who-icf-framework
#14
Soheil Mahdi, Katja Albertowski, Omar Almodayfer, Vaia Arsenopoulou, Sara Carucci, José Carlos Dias, Mohammad Khalil, Ane Knüppel, Anika Langmann, Marlene Briciet Lauritsen, Graccielle Rodrigues da Cunha, Tokio Uchiyama, Nicole Wolff, Melissa Selb, Mats Granlund, Petrus J de Vries, Lonnie Zwaigenbaum, Sven Bölte
This is the fourth international preparatory study designed to develop International Classification of Functioning, Disability and Health (ICF, and Children and Youth version, ICF-CY) Core Sets for Autism Spectrum Disorder (ASD). Examine functioning of individuals diagnosed with ASD as documented by the ICF-CY in a variety of clinical settings. A cross-sectional study was conducted, involving 11 units from 10 countries. Clinical investigators assessed functioning of 122 individuals with ASD using the ICF-CY checklist...
June 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29383807/rbmx-is-a-component-of-the-centromere-noncoding-rnp-complex-involved-in-cohesion-regulation
#15
Yukiko Cho, Takashi Ideue, Megumi Nagayama, Norie Araki, Tokio Tani
Satellite I RNA, a noncoding (nc)RNA transcribed from repetitive regions in human centromeres, binds to Aurora kinase B and forms a ncRNP complex required for chromosome segregation. To examine its function in this process, we purified satellite I ncRNP complex from nuclear extracts prepared from asynchronized or mitotic (M) phase-arrested HeLa cells and then carried out LC/MS to identify proteins bound to satellite I RNA. RBMX (RNA-binding motif protein, X-linked), which was isolated from M phase-arrested cells, was selected for further characterization...
March 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29277961/liver-resection-of-hepatocellular-carcinoma-in-patients-with-portal-hypertension-and-multiple-tumors
#16
Takao Ohkubo, Yutaka Midorikawa, Hisashi Nakayama, Masamichi Moriguchi, Osamu Aramaki, Shintaro Yamazaki, Tokio Higaki, Tadatoshi Takayama
AIM: Liver resection for hepatocellular carcinoma (HCC) has been recommended only for patients with a single tumor without portal hypertension. We aimed to validate this treatment strategy that is based on by the Barcelona Clinic Liver Cancer staging system. METHODS: Patients undergoing liver resection were divided into two groups: patients with single HCC without portal hypertension (Group 1) and those with at least one factors of portal hypertension and multiple tumors, up to three lesions each ≤3 cm (Group 2)...
May 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29227001/antiviral-therapy-for-hepatitis-b-virus-during-second-pregnancies
#17
Yasuhiro Wakano, Tokio Sugiura, Takeshi Endo, Koichi Ito, Mitsuyoshi Suzuki, Hitoshi Tajiri, Yasuhito Tanaka, Shinji Saitoh
Mother-to-child transmission of the hepatitis B virus (HBV) is a major concern for infected mothers, especially after their first child has become an HBV carrier despite immunoprophylaxis. Eight mothers whose first child had become an HBV carrier despite immunoprophylaxis were referred for antiviral therapy during the subsequent pregnancy. All pregnant women were seropositive for both the hepatitis B surface antigen and hepatitis B e antigen. In the treatment group (three receiving lamivudine and two receiving tenofovir), mother-to-child transmission of the HBV was successfully prevented in all infants (5/5)...
March 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29157042/head-out-immersion-in-hot-water-increases-serum-bdnf-in-healthy-males
#18
Daisuke Kojima, Takeshi Nakamura, Motohiko Banno, Yasunori Umemoto, Tokio Kinoshita, Yuko Ishida, Fumihiro Tajima
PURPOSE: Brain-derived neurotrophic factor (BDNF) is an important neurotrophin. The present study investigated the effects of head-out water immersion (HOI) on serum BDNF concentrations. METHODS: Eight healthy men performed 20 min head-out water immersion at 42 °C (hot-HOI) and 35 °C (neutral-HOI). These experimental trials were administered in a randomised order separated by at least 7 days. Venous blood samples were withdrawn at rest, immediately after the 20-min HOI, as well as at 15 and 30 min after the end of the HOI...
September 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29115414/anti-oncogenic-activities-of-cyclin-d1b-sirna-on-human-bladder-cancer-cells-via-induction-of-apoptosis-and-suppression-of-cancer-cell-stemness-and-invasiveness
#19
Chul Jang Kim, Tokio Terado, Yukihiro Tambe, Ken-Ichi Mukaisho, Hiroyuki Sugihara, Akihiro Kawauchi, Hirokazu Inoue
The human cyclin D1 gene generates two major isoforms, cyclin D1a and cyclin D1b, by alternative splicing. Although cyclin D1b mRNA is hardly expressed in normal human tissues, it is detected in approximately 60% of human bladder cancer tissues and cell lines. In the present study, to assess the therapeutic ability of cyclin D1b siRNA, we investigated the anti-oncogenic effects of cyclin D1b siRNA on human bladder cancer cell lines, SBT31A and T24, which express cyclin D1b mRNA. Knockdown of cyclin D1b by specific siRNA significantly suppressed cell proliferation, in vitro cell invasiveness and three-dimensional (3D) spheroid formation in these cell lines...
January 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29073250/effects-of-physiatrist-and-registered-therapist-operating-acute-rehabilitation-pror-in-patients-with-stroke
#20
Tokio Kinoshita, Yukihide Nishimura, Takeshi Nakamura, Takamasa Hashizaki, Daisuke Kojima, Makoto Kawanishi, Hiroyasu Uenishi, Hideki Arakawa, Takahiro Ogawa, Yoshi-Ichiro Kamijo, Takashi Kawasaki, Fumihiro Tajima
OBJECTIVE: Clinical evidence suggests that early mobilization of patients with acute stroke improves activity of daily living (ADL). The purpose of this study was to compare the utility of the physiatrist and registered therapist operating acute rehabilitation (PROr) applied early or late after acute stroke. SUBJECTS AND METHODS: This study was prospective cohort study, assessment design. Patients with acute stroke (n = 227) admitted between June 2014 and April 2015 were divided into three groups based on the time of start of PROr: within 24 hours (VEM, n = 47), 24-48 hours (EM, n = 77), and more than 48 hours (OM, n = 103) from stroke onset...
2017: PloS One
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