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Injury of high strain rate

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https://www.readbyqxmd.com/read/29297365/regional-physiology-of-ards
#1
REVIEW
Luciano Gattinoni, Tommaso Tonetti, Michael Quintel
The acute respiratory distress (ARDS) lung is usually characterized by a high degree of inhomogeneity. Indeed, the same lung may show a wide spectrum of aeration alterations, ranging from completely gasless regions, up to hyperinflated areas. This inhomogeneity is normally caused by the presence of lung edema and/or anatomical variations, and is deeply influenced by the gravitational forces.For any given airway pressure generated by the ventilator, the pressure acting directly on the lung (i.e., the transpulmonary pressure or lung stress) is determined by two main factors: 1) the ratio between lung elastance and the total elastance of the respiratory system (which has been shown to vary widely in ARDS patients, between 0...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29286474/mouse-model-for-pancreas-transplantation-using-a-modified-cuff-technique
#2
Benno Cardini, Rupert Oberhuber, Sven R Hein, Rebecca Eiter, Martin Hermann, Markus Kofler, Stefan Schneeberger, Gerald Brandacher, Manuel Maglione
Mouse models have several advantages in transplantation research, including easy handling, a variety of genetically well-defined strains, and the availability of the widest range of molecular probes and reagents to perform in vivo as well as in vitro studies. Based on our experience with various murine transplantation models, we developed a heterotopic pancreas transplantation model in mice with the intent to analyze mechanisms underlying severe ischemia reperfusion injury-associated early graft damage. In contrast to previously described techniques using suture techniques, herein we describe a new procedure using a non-suture cuff technique...
December 16, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29230501/-development-of-ground-based-physician-staffed-emergency-missions-in-the-city-of-leipzig-from-2003-to-2013
#3
K Bader, M Bernhard, A Gries, M Kaul, R Schröder, A Ramshorn-Zimmer
BACKGROUND: The annual number of physician-based emergency missions reported is continuously increasing. Data from large cities concerning this development over long periods is sparse. MATERIAL AND METHODS: In this retrospective study the charts of all ground-based physician-staffed emergency missions in the city of Leipzig for the first quarters of 2003 and 2013 were analyzed. Patient characteristics, injury and illness severities, mission location, hospital admission rate, as well as emergency interventions were collated...
December 11, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29229143/myocardial-functional-changes-in-transfemoral-versus-transapical-aortic-valve-replacement
#4
Niraj Asthana, Aditya Mantha, Eric H Yang, William Suh, Olcay Aksoy, Richard J Shemin, Gabriel Vorobiof, Peyman Benharash
BACKGROUND: Transcatheter aortic valve replacement (TAVR) has greatly expanded the treatment options available for patients with severe aortic stenosis at high surgical risk. MATERIALS AND METHODS: We compared changes in myocardial function in TAVR with a transfemoral (TF) versus a transapical (TA) approach at a major tertiary hospital from 2012-2016. Traditional echocardiographic measures of cardiac structure and function were tracked, alongside the use of two-dimensional speckle tracking echocardiography to measure myocardial strain and strain rates...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29202784/sprint-and-jump-performance-in-elite-male-soccer-players-following-a-10-week-nordic-hamstring-exercise-protocol-a-randomised-pilot-study
#5
K Krommes, J Petersen, M B Nielsen, P Aagaard, P Hölmich, K Thorborg
OBJECTIVE: The preseason Nordic Hamstring Protocol (NHP) reduces hamstring strain injuries in football players. Despite persisting injury rates, elite clubs are reluctant to apply the NHP often over concerns of negative impacts on performance. This pilot study investigated if sprint or jump-performance outcomes tended to increase or decrease following implementation of the NHP in elite male soccer-players. RESULTS: Nineteen male soccer players from the Danish 1st division were randomised to perform NHP (27 sessions) during pre-season, or to control group (CG)...
December 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29172124/material-mapping-strategy-to-improve-the-predicted-response-of-the-proximal-femur-to-a-sideways-fall-impact
#6
W S Enns-Bray, H Bahaloo, I Fleps, O Ariza, S Gilchrist, R Widmer, P Guy, H Pálsson, S J Ferguson, P A Cripton, B Helgason
Sideways falls are largely responsible for the highly prevalent osteoporotic hip fractures in today's society. These injuries are dynamic events, therefore dynamic FE models validated with dynamic ex vivo experiments provide a more realistic simulation than simple quasi-static analysis. Drop tower experiments using cadaveric specimens were used to identify the material mapping strategy that provided the most realistic mechanical response under impact loading. The present study tested the addition of compression-tension asymmetry, tensile bone damage, and cortical-specific strain rate dependency to the material mapping strategy of fifteen dynamic FE models of the proximal femur, and found improved correlations and reduced error for whole bone stiffness (R2 = 0...
October 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29169199/-internet-addiction-suicidality-and-non-suicidal-self-harming-behavior-a-systematic-review
#7
Toni Andreas Steinbüchel, Stephan Herpertz, Ina Külpmann, Aram Kehyayan, Jan Dieris-Hirche, Bert Theodor Te Wildt
Background Internet addiction (IA) is associated with a high rate of co-morbid mental disorders, especially depression, anxiety disorders, ADHD and personality disorders and a considerable level of psychological strain. In terms of risk assessment, the present work investigates the current research literature on suicidal behavior and non-suicidal self-injurious behavior (NSSI). Methods We performed a systematic literature search in 14 databases on title and abstract level for the most common keywords for IA, NSSI and suicidality...
November 23, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29162240/influence-of-gap-size-screw-configuration-and-nail-materials-in-the-stability-of-anterograde-reamed-intramedullary-nail-in-femoral-transverse-fractures
#8
Sergio Gabarre, Jorge Albareda, Luis Gracia, Sergio Puértolas, Elena Ibarz, Antonio Herrera
Femoral shaft fractures are among the most severe injuries of the skeleton. They are associated with high morbidity and mortality. The most appropriate treatment depending on the type of fracture and location level should be chosen. A finite element model of the femur has been developed, analyzing various types of fractures in the subtrochanteric and diaphyseal supracondylar area, with several gap sizes, being stabilized with a single combination of screws for the intramedullary nail. The mechanical strength of the nail against bending and compression efforts was studied comparing two materials for the nail: stainless steel and titanium alloy...
November 2017: Injury
https://www.readbyqxmd.com/read/29115945/mechanical-strain-to-maxillary-incisors-during-direct-laryngoscopy
#9
Milo Engoren, Lauryn R Rochlen, Matthew V Diehl, Sarah S Sherman, Elizabeth Jewell, Mary Golinski, Paul Begeman, John M Cavanaugh
BACKGROUND: While most Direct laryngoscopy leads to dental injury in 25-39% of cases. Dental injury occurs when the forces and impacts applied to the teeth exceed the ability of the structures to dissipate energy and stress. The purpose of this study was to measure strain, (which is the change produced in the length of the tooth by a force applied to the tooth) strain rate, and strain-time integral to the maxillary incisors and determine if they varied by experience, type of blade, or use of an alcohol protective pad (APP)...
November 7, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29091888/oroxylin-a-suppresses-influenza-a-virus-replication-correlating-with-neuraminidase-inhibition-and-induction-of-ifns
#10
Jing Jin, Shuo Chen, Dechuan Wang, Yuanjin Chen, Yuxu Wang, Min Guo, Changlin Zhou, Jie Dou
Because it is highly contagious, the influenza A virus (IAV) has the potential to cause pandemics in humans. The emergence of drug-resistant strains requires the development of new chemical therapeutics. Oroxylin A (OA) is a flavonoid which has been shown to have antioxidant and antitumor effects. However, intensive studies in which OA fights against different influenza virus strains and the underlying antiviral mechanisms have not been reported. In our study, the antiviral activities in cells and in mice, the preliminary mechanisms of OA were investigated...
October 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29073840/a-novel-apparatus-measuring-knee-flexor-strength-during-various-hamstring-exercises-a-reliability-and-retrospective-study
#11
Jack T Hickey, Peter F Hickey, Nirav Maniar, Ryan G Timmins, Morgan D Williams, Christian A Pitcher, David A Opar
Study Design Reliability and case-control injury study. Background Knee flexor strength is a key variable when dealing with hamstring strain injury (HSI) and methodologies of objective measurement are often limited to single exercises. Objectives To establish test re-test reliability of a novel apparatus measuring knee flexor strength during various hamstring exercises; to investigate whether these measures detect between-leg differences in males with and without history of unilateral HSI. Methods Twenty males without and ten males with previous unilateral HSI participated...
October 26, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29061984/region-and-species-dependent-mechanical-properties-of-adolescent-and-young-adult-brain-tissue
#12
David B MacManus, Baptiste Pierrat, Jeremiah G Murphy, Michael D Gilchrist
Traumatic brain injuries, the leading cause of death and disability in children and young adults, are the result of a rapid acceleration or impact of the head. In recent years, a global effort to better understand the biomechanics of TBI has been undertaken, with many laboratories creating detailed computational models of the head and brain. For these models to produce realistic results they require accurate regional constitutive data for brain tissue. However, there are large differences in the mechanical properties reported in the literature...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051332/parenchymal-strain-heterogeneity-during-oscillatory-ventilation-why-two-frequencies-are-better-than-one
#13
Jacob Herrmann, Merryn H Tawhai, David W Kaczka
High frequency oscillatory ventilation (HFOV) relies on low tidal volumes cycled at supraphysiologic rates, producing fundamentally different mechanisms for gas transport and exchange compared with conventional mechanical ventilation. Despite the appeal of using low tidal volumes to mitigate the risks of ventilator-induced lung injury (VILI), HFOV has not improved mortality for most clinical indications. This may be due to non-uniform and frequency-dependent distribution of flow throughout the lung. The goal of this study was to compare parenchymal strain heterogeneity during eucapnic HFOV when using oscillatory waveforms that consisted of either a single discrete frequency or two simultaneous frequencies...
October 19, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29048928/epidemiology-of-shoulder-and-elbow-injuries-among-united-states-high-school-baseball-players-school-years-2005-2006-through-2014-2015
#14
Michael G Saper, Lauren A Pierpoint, Wei Liu, R Dawn Comstock, John D Polousky, James R Andrews
BACKGROUND: Shoulder and elbow injuries are common in young athletes, especially high school baseball players. Understanding the risk factors associated with baseball injuries is an essential first step in the development of injury prevention strategies. PURPOSE: To provide a comprehensive understanding of the epidemiology of shoulder and elbow injuries among high school baseball players in the United States. STUDY DESIGN: Descriptive epidemiological study...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29043832/high-frequency-oscillation-for-adult-patients-with-acute-respiratory-distress-syndrome-a-systematic-review-and-meta-analysis
#15
Ewan Goligher, Laveena Munshi, Neill Kj Adhikari, Maureen O Meade, Carol Hodgson, Hannah Wunsch, Elizabeth Uleryk, Ognjen Gajic, Marcelo Amato, Niall D Ferguson, Gordon D Rubenfeld, Eddy Fan
RATIONALE: By minimizing tidal lung strain and maintaining alveolar recruitment, high frequency oscillatory ventilation (HFOV) may protect against ventilator-induced lung injury. OBJECTIVES: To summarize the current evidence in support of the use of HFOV in adult patients with ARDS. METHODS: We conducted a systematic review and meta-analysis of randomized trials comparing mortality rates with the use of HFOV vs. conventional mechanical ventilation for adult patients with acute respiratory distress syndrome...
October 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28952868/comparison-of-thigh-muscle-strain-occurrence-and-injury-patterns-between-male-and-female-high-school-soccer-athletes
#16
Kevin M Cross, Kelly K Gurka, Susan Saliba, Mark Conaway, Jay Hertel
CONTEXT: Thigh muscles strains are among the most common injuries in high school soccer for both males and females. Similar results have been reported among collegiate soccer players, specifically for hamstring strains. In collegiate soccer, males have a higher injury rate than women although they share common injury characteristics. Currently, no studies exist comparing the injury rate or injury characteristics of thigh muscle strains between sexes playing high school soccer. OBJECTIVE: To compare thigh muscle strain injury rates and injury event characteristics among sexes participating in high school soccer...
September 27, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28888435/resuscitation-and-growth-kinetics-of-sub-lethally-injured-listeria-monocytogenes-strains-following-fluorescence-activated-cell-sorting-facs
#17
Thulani Sibanda, Elna M Buys
This study investigated the effect of acid (pH4.2), osmotic (10% NaCl) and heat (55°C for 30min) stress induced injury on Listeria monocytogenes strains ATCC19115, 69, 159/10 and 243 using differential plating and flow cytometry coupled with membrane integrity indicators, thiazole orange (TO) and propidium iodide (PI) staining. Growth kinetics of injured cells sorted by fluorescence activated cell sorting (FACS) were studied at 4, 25 and 37°C. The percentage of cell injury detectable by both flow cytometry and differential plating varied significantly among strains and stress treatments (p<0...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28884476/probiotics-for-preventing-urinary-tract-infection-in-people-with-neuropathic-bladder
#18
REVIEW
Swee-Ling Toh, Claire L Boswell-Ruys, Bon San B Lee, Judy M Simpson, Kate R Clezy
BACKGROUND: Neuropathic or neurogenic bladder describes a process of dysfunctional voiding as the result of injury in the brain, spinal cord or nerves innervating the bladder. People with neuropathic bladder, such as from spinal cord injury (SCI), are at significant risk of morbidity from urinary tract infections (UTI). Effective methods to prevent UTI in people with SCI have been sought for many years. Probiotics (micro-organisms that exert beneficial health effects in the host) have been recommended for bacterial interference of the urological tract to reduce colonisation by uropathogen and to manage the dual problems of infection and antibiotic resistance...
September 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28878888/cardiovascular-and-thermal-strain-during-3-4%C3%A2-days-of-a-metabolically-demanding-cold-weather-military-operation
#19
John W Castellani, Marissa G Spitz, Anthony J Karis, Svein Martini, Andrew J Young, Lee M Margolis, J Phillip Karl, Nancy E Murphy, Xiaojiang Xu, Scott J Montain, Jamie A Bohn, Hilde K Teien, Pål H Stenberg, Yngvar Gundersen, Stefan M Pasiakos
BACKGROUND: Cardiovascular (CV) and thermal responses to metabolically demanding multi-day military operations in extreme cold-weather environments are not well described. Characterization of these operations will provide greater insights into possible performance capabilities and cold injury risk. METHODS: Soldiers from two cold-weather field training exercises (FTX) were studied during 3-day (study 1, n = 18, age: 20 ± 1 year, height: 182 ± 7 cm, mass: 82 ± 9 kg) and 4-day (study 2, n = 10, age: 20 ± 1 year, height: 182 ± 6 cm, mass: 80...
2017: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/28859497/first-report-of-coexistence-of-ampc-beta-lactamase-genes-in-klebsiella-pneumoniae-strains-isolated-from-burn-patients
#20
Roya Ghanavati, Davood Darban-Sarokhalil, Fateme Navab-Moghadam, Hossein Kazemian, Gholamreza Irajian, Shabnam Razavi
Klebsiella spp. are among the most frequently isolated bacteria from burn wounds. These organisms are among the most important opportunistic pathogens, causing hospital-acquired and healthcare-associated infections worldwide. Limited information is available about prevalence of AmpC-producing Klebsiella pneumoniae from burn patients. Therefore, the aim of this study was to determine the characterization of AmpC beta-lactamase among K. pneumoniae isolated from burn patients. Samples were collected from wound specimens of patients with burn injury from a burn hospital in Tehran during 18 months (March 2015 to August 2016)...
September 1, 2017: Acta Microbiologica et Immunologica Hungarica
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