Qixuan Shi, Shenghe Zeng, Ruiqi Yu, Mo Li, Cong Shen, Xuan Zhang, Chanjing Zhao, Jianming Zeng, Bin Huang, Jieying Pu, Cha Chen
Pseudomonas aeruginosa is an opportunistic pathogen that causes acute and chronic infections in immunocompromised individuals. Small regulatory RNAs (sRNAs) regulate multiple bacterial adaptations to environmental changes, especially virulence. Our previous study showed that sRNA PrrH negatively regulates the expression of a number of virulence factors, such as pyocyanin, rhamnolipid, biofilm, and elastase in the P. aeruginosa strain PAO1. However, previous studies have shown that the prrH -deficient mutant attenuates virulence in an acute murine lung infection model...
January 30, 2024: Microbiology Spectrum