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Endometriosis surgery

Dominique de Ziegler, Paul Pirtea, Marie Carbonnel, Marine Poulain, Ettore Cicinelli, Carlo Bulletti, Konstantinos Kostaras, George Kontopoulos, David Keefe, Jean Marc Ayoubi
Endometriosis - a disease causing pain and infertility - is encountered in nearly 50% of infertile women. While medical treatment is effective on pain and recurrence of symptoms after surgical excision, it is of no help for treating infertility for which the only options considered are surgery and ART. Surgery enhances the chances of conceiving naturally during the 12-18 ensuing months irrespective of the stage of the disease. Surgery however is of no help when ART is considered, as it does not improve outcome and can only harm the ovarian response to stimulation...
November 3, 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
Javier García-Solares, Marie-Madeleine Dolmans, Jean-Luc Squifflet, Jacques Donnez, Olivier Donnez
OBJECTIVE: To study the mechanisms of invasion and innervation of deep endometriosis in women. DESIGN: Morphologic and immunohistochemical analysis of human endometriotic lesions. SETTING: Academic research unit. PATIENT(S): Seventeen biopsy samples of deep endometriotic lesions were collected from patients undergoing surgery for deep endometriosis. INTERVENTION(S): The endometriotic samples were divided into two parts: the front (the most invasive area of lesions, approaching rectal infiltration) and center (the area close to the posterior part of the cervix)...
December 2018: Fertility and Sterility
Bruce A Lessey, Stephan Gordts, Olivier Donnez, Edgardo Somigliana, Charles Chapron, Juan A Garcia-Velasco, Jacques Donnez
No abstract text is available yet for this article.
December 2018: Fertility and Sterility
D K Hapangama, J Drury, L Da Silva, H Al-Lamee, A Earp, A J Valentijn, D P Edirisinghe, P A Murray, A T Fazleabas, C E Gargett
STUDY QUESTION: Is endometriosis associated with abnormally located endometrial basalis-like (SSEA1+/SOX9+) cells in the secretory phase functionalis and could they contribute to ectopic endometriotic lesion formation? SUMMARY ANSWER: Women with endometriosis had an abnormally higher number of basalis-like SSEA1+/SOX9+ epithelial cells present in the stratum functionalis and, since these cells formed 3D structures in vitro with phenotypic similarities to ectopic endometriotic lesions, they may generate ectopic lesions following retrograde menstruation...
November 29, 2018: Human Reproduction
Leon Foster, Stephen J Robson, Anusch Yazdani, Pauline Y O'Shaughnessy
OBJECTIVE: Improvements in success rates of assisted reproduction led to predictions that infertility surgery in both women and men would become extinct in developed countries. We sought to identify the changes in reproductive surgery that occurred between 2001 and 2015 to determine whether these predictions have been accurate. DESIGN: The Australian Institute of Health and Welfare (AIHW) national procedural dataset and the Australian Medicare Benefits Scheme (MBS) claims database were searched for procedure data for male and female reproductive surgery and assisted reproduction from January 2001 to December 2015...
November 28, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Elisabeth Bean, Joel Naftalin, Davor Jurkovic
BACKGROUND: Endometriosis, fibroids and gynecological malignancy can all impact the pelvic ureters. Ureteric involvement is likely to be an important factor in determining the extent and timing of surgery in women with these conditions and assessment of the pelvic ureters is now a recommended component of the imaging work-up for women with endometriosis. The aim of this paper is to provide a step-by-step guide for the identification and assessment of the distal ureters during pelvic ultrasound...
November 26, 2018: Ultrasound in Obstetrics & Gynecology
Elodie Bonin, Valérie Bridoux, Rachid Chati, Sabrina Kermiche, Julien Coget, Jean Jacques Tuech, Horace Roman
OBJECTIVE: Deep endometriosis may simultaneously infiltrate the vagina and the rectosigmoid, which associated resection may increase the risk of postoperative complications. Among these complications, rectovaginal fistula is one of the worst. To reduce the risk of rectovaginal fistula and related complications, surgeons may employ diverting stoma. The literature is rich in data concerning the usefulness of stoma in patients managed for low rectal cancer. However, extrapolation of these data to patients managed for rectal endometriosis is disputable...
November 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Raphael Ouede, Blaise Demine Alexandre, Ayegnon Kouakou Gregoire, Landry Kohou-Kone, Edouard N'guessan, Maurice Gabin Kouacou, Jean-Marcel Ahui Brou, Flavien Kouassi Kendja, Yves Tanauh
This study aims to propose a therapeutic approach for catamenial pneumothorax based on outcomes reported in 18 cases. We conducted a retrospective study of 18 female elderly patients with an average age of 32.2 years who had undergone surgery for right (16 cases) and bilateral catamenial pneumothorax (2 cases) from January 1994 to December 2016. The patients were divided into 3 groups on the basis of the evolution of our surgical capability over time: group 1(G1) from January 1994 to June 2006, group 2 (G2) from July 2006 to February 2008, group 3(G3) from March 2008 to December 2016, these groups were composed of 5, 2 and 11 patients respectively...
2018: Pan African Medical Journal
Amilcar Barreta, Luís Otávio Sarian, Amanda Canato Ferracini, Larissa Bastos Eloy Costa, Priscila Gava Mazzola, Liliana de Angelo Andrade, Sophie Derchain
Ovarian clear cell and endometrioid carcinomas (Type I) are thought to develop from endometriosis. ARID1A loss of expression is known to be related to the promotion of the endometriosis carcinogenesis. Despite the diverse origins and prognosis of Type I and Type II carcinomas, surgery followed by platinum-based chemotherapy is the mainstay of treatment for both. Limited knowledge about the expression of targeted therapies' biomarkers prevents the use of such markers as potential guides for tailored treatment...
November 14, 2018: Human Pathology
Luciana Ferella, Juan Ignacio Bastón, Mariela Andrea Bilotas, José Javier Singla, Alejandro Martín González, Carla Noemí Olivares, Gabriela Fabiana Meresman
RESEARCH QUESTION: Can carnosic acid, (CA) rosmarinic acid (RA) and wogonin (WG) inhibit the growth of cultured human endometrial stromal cells and endometriotic-like lesions induced in a BALB/c model of endometriosis? DESIGN: Primary stromal cell cultures were established from endometrial biopsies from women with endometriosis and controls. The human endometrial stromal cell line T-HESC was also used for in-vitro experiments. Endometriosis was surgically induced in BALB/c mice, which were randomly assigned to CA 2 mg/kg/day (n = 11); CA 20 mg/kg/day (n = 10); RA 1 mg/kg/day (n = 11); RA 3 mg/kg/day (n = 10); WG 20 mg/kg/day (n = 12); intraperitoneal vehicle control (n = 8) or oral vehicle control (n = 11)...
October 26, 2018: Reproductive Biomedicine Online
Annelyn Torres-Reverón, Leslie L Rivera-Lopez, Idhaliz Flores, Caroline B Appleyard
Endometriosis is a disorder in which endometrial tissue is found outside the uterus causing pain, infertility and stress. Finding effective, non-hormonal and long-term treatments for endometriosis still remains one of the most significant challenges in the field. Corticotropin releasing hormone (CRH) is one of the main signaling peptides within the hypothalamic pituitary adrenal (HPA) axis released in response to stress. CRH can affect nervous and visceral tissues such as the uterus and gut via activation of two types of CRH receptors: CRHR1 and CRHR2...
2018: PloS One
Stefano Guerriero, M Angela Pascual, Silvia Ajossa, Ignacio Rodriguez, Michal Zajicek, Martino Rolla, Noelia Llop Rams, Vered Yulzari, Ron Bardin, Francesca Buonomo, Ornella Comparetto, Maura Perniciano, Luca Saba, Valerio Mais, Juan Luis Alcazar
OBJECTIVE: The aim of the present study was to assess the learning curves of trainees during a structured off-line/hands-on training program on the diagnosis of deep infiltrating endometriosis (DIE). METHODS: A two-week training program was conducted. One day was devoted to theoretical issues and guided off-line analysis of 10 volumes of three-dimensional (3D) ultrasound. During the following days, five sessions of real-time sonographic examinations were performed in a DIE referral center Ultrasound unit...
November 13, 2018: Ultrasound in Obstetrics & Gynecology
Leszek Teresiński, Olimpia Sipak, Aleksandra Rył, Marek Masiuk, Iwona Rotter, Weronika Ratajczak, Malwina Łazowska, Maria Słomczyńska, Mariola Marchlewicz, Beata Karakiewicz, Maria Laszczyńska
INTRODUCTION: The morphology of the endometrium constantly changes in the reproductive period, depending on the levels of ovarian steroid hormones, and undergoes atrophic changes during menopause as a result of their insufficiency. The purpose of this study was to analyze morphological and morphometric changes in the mucous and muscle layers of the uterine wall in postmenopausal women, and to assess localization and number of cells showing the expression of steroid hormone receptors, namely estrogen receptor α (ER-α), progesterone receptor (PR), and androgen receptor (AR) in glandular epithelial cells and smooth muscle cells in particular groups of women...
November 14, 2018: Histology and Histopathology
J I Ikechebelu, G U Eleje, N N Joe-Ikechebelu, C D Okafor, A O Akintobi
Objective: The aim of this study is to determine the prevalence and patterns of adhesions in infertile women with prior open myomectomy compared with women without prior pelvic-abdominal surgery. Methods: A nested case-control study of infertile women who had diagnostic laparoscopy after open myomectomy between January 2008 and June 2015 in Life Institute for Endoscopy Limited, Nnewi Nigeria, was conducted. At diagnostic laparoscopy, the presence, site, and quality (density) of adhesions was noted and recorded...
November 2018: Nigerian Journal of Clinical Practice
Elaine Denny, Annalise Weckesser, Georgina Jones, Stavroula Bibila, Jane Daniels, Siladitya Bhattacharya
Background: Endometriosis is a common cause of chronic pelvic pain which can relapse after surgery, yet little research has been conducted on women's experience of medical treatments for prevention of recurrence and the influence of this on participation in clinical trials. Methods: This study explored women's past experiences with medical treatments for endometriosis symptoms and the impact this has on their motivation to enter the pilot phase of a post-conservative surgery clinical trial, PRE-EMPT: Preventing Recurrence of Endometriosis by Means of long acting Progestogen Therapy...
2018: Pilot and Feasibility Studies
Weilin Zheng, Lixing Cao, Zheng Xu, Yuanyuan Ma, Xuefang Liang
Endometriosis is caused by the growth or infiltration of endometrial tissues outside of the endometrium and myometrium. Symptoms include pain and infertility. Surgery and hormonal therapy are widely used in Western medicine for the treatment of endometriosis; however, the side effects associated with this practice include disease recurrence and menopause, which can severely influence quality of life. Angiogenesis is the main biological mechanism underlying the development of endometriosis. Numerous natural products and Chinese medicines with potent anti-angiogenic effects have been investigated, and the molecular basis underlying their therapeutic effects in endometriosis has been explored...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
A Guenego, S Mesrine, L Dartois, L Leenhardt, F Clavel-Chapelon, M Kvaskoff, M C Boutron-Ruault, F Bonnet
BACKGROUND: Thyroid cancers are threefold more frequent in women than in men. A role of reproductive or hormonal factors has been suggested but with contradictory results. We investigated potential associations between history of hysterectomy, with or without oophorectomy, and history of benign gynecological disease (uterine fibroids, endometriosis) and the incidence of differentiated thyroid cancer, in a large French prospective cohort. METHODS: 89,340 women from the E3N cohort were followed up between 1990 and 2012...
November 3, 2018: Clinical Endocrinology
O Biobaku, B M Afolabi, V Ajayi, I Oyetunji, A Ajayi
Endometriosis is a common progressive gynecological disorder which often poses a mystery to women affected and to health care provider alike. It is a condition in which tissue that normally grows inside the uterus (endometrium) grows outside it. It is estimated that about 6-10% of women in the reproductive age group worldwide have endometriosis. This report is likely to be an underestimated figure because many are misdiagnosed, misinterpreted or mislabeled. Many women with endometriosis experience few or no symptoms but those symptomatic typically present with pelvic pain, infertility, or an adnexal mass, and may require surgery...
September 2018: West African Journal of Medicine
Achmad Kemal Harzif, Melisa Silvia, Ana Mariana, Lydia Olivia, Bara Tracy Lovita, Budi Wiweko
INTRODUCTION: Endometriosis is a frequent gynecological disorder. Its findings on the abdominal wall are rare cases, usually reported with a history of former surgery. The activation of PPARy expression could be one of alternative non-hormonal treatment for endometriosis. PRESENTATION OF CASE: A patient, 34 years old, suspected of endometriosis since 5 years ago because of pain during menstruation. Since the last 4 months, she had worsening of dysmenorrhea and palpable lumps during menses...
October 24, 2018: International Journal of Surgery Case Reports
Nadejda Cojocari, Laura Ciutacu, Ioana Lupescu, Vlad Herlea, Mihaela Elena Vasilescu, Mirela Patricia Sîrbu
Background: Parietal endometriosis (PE) is a rare pathology, which usually develops in fertile women, after surgical or gynecological procedures. Its quasi-pathognomonic symptomatology consists in catamenial pain with or without palpable mass. The diagnosis can be challenging because it may be confused with stitch granuloma, hematoma, hernia or even cancer. Patients and methods: Between January 2007 and December 2017, 10 female patients with PE were referred for diagnosis and surgery to our clinic. Results: The mean age of the patients was 35...
2018: Chirurgia
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