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Stiff Person

Muhammad Sohaib, Ali Sarfaraz Siddiqui
We herein describe the successful anesthetic management of a patient with stiff person syndrome undergoing right total hip replacement under spinal anesthesia. We also describe the problems associated with general anesthesia. The advantage of using regional anesthesia in these patients is the avoidance of muscle relaxants. The use of general anesthesia carries the risk of hypotonia in stiff person syndrome postoperatively due to enhancement of γ aminobutyric acid (GABA) action on synaptic transmission by drugs that have a γ GABA agonistic action...
December 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Lisanne Tap, Annegreet van Opbroek, Wiro J Niessen, Marion Smits, Francesco Us Mattace-Raso
Purpose: Cerebral white matter lesions (WML) and brain atrophy are frequent in older persons and are associated with adverse outcomes. It has been suggested that aortic stiffness plays a role in the pathogenesis of WML and gray matter (GM) loss. There is, however, little evidence on the association between aortic stiffness and brain integrity in older patients. In this study, we investigated whether aortic stiffness is associated with WML and GM volume in older patients with cognitive and functional complaints...
2018: Clinical Interventions in Aging
Deepa Dash, Kavish Ihtisham, Madhavi Tripathi, Manjari Tripathi
We aimed to study the proportion of patients with movement disorders in seropositive autoimmune encephalitis of non-neoplastic aetiology and also to describe the spectrum of movement disorders in them. We prospectively screened 362 patients of age >12 years with encephalitis of unknown aetiology for a panel of antibodies for autoimmune encephalitis. Demographic and clinical characteristics with focus on the movement disorders were recorded. We also evaluated the differences in the spectrum of movement disorder based on various age groups and antibody positivity...
November 16, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Hans Scheers, Tim S Nawrot, Benoit Nemery, Lidia Casas
BACKGROUND: Short-term exposure to ambient air pollution triggers acute cardiovascular events. Here, we evaluate the association of exposure to ambient air pollution with two intermediate cardiovascular endpoints: blood pressure and carotid stiffness. METHODS: In a one-year panel study, we included 20 healthy volunteers (10 male-female couples aged 59-75 years) with air pollution and health parameters measured every two months at their region of residence (Leuven, Belgium) and twice during two ten-day periods in two locations, one with higher (Milan, Italy) and one with lower (Vindeln, Sweden) air pollution levels (220 observations)...
November 19, 2018: Environmental Health: a Global Access Science Source
Kentaro Matsuura, Nobuhiro Aizawa, Hirayuki Enomoto, Shuhei Nishiguchi, Hidenori Toyoda, Takashi Kumada, Etsuko Iio, Kyoko Ito, Shintaro Ogawa, Masanori Isogawa, Harvey J Alter, Yasuhito Tanaka
Background: Evaluating the progression of hepatic fibrosis in chronic hepatitis C (CHC) is critical, and identifying a predictive biomarker for fibrosis will be helpful for implementing personalized surveillance of hepatocellular carcinoma after the elimination of hepatitis C virus by antiviral therapy. This study aimed to investigate the association of circulating let-7a-5p levels with severity of hepatic fibrosis. Methods: We analyzed circulating let-7a-5p levels in serum and serum-derived extracellular vesicles (EVs) in 84 Japanese CHC patients who underwent a liver biopsy by quantitative real-time polymerase chain reaction, and investigated the association of its levels with histological hepatic fibrotic stage, liver stiffness, and several hepatic fibrotic markers...
November 2018: Open Forum Infectious Diseases
Toshihiro Kita, Kazuo Kitamura
BACKGROUND AND OBJECTIVE: Seasonal variation of blood pressure (BP) is well known, and a relationship between increases in BP and the incidence of cardiovascular accidents (CVAs) in the winter has been reported. Parameters of arterial stiffness may exhibit seasonal variation; however, available data are currently limited. Novel arterial stiffness indexes, namely the arterial velocity pulse index (AVI) and arterial pressure-volume index (API), can be determined through usual maneuver for BP measurement during the regular examination in the outpatient clinic...
November 8, 2018: Clinical and Experimental Hypertension: CHE
T-W Kang, J-H Lee, D-H Park, H-S Cynn
Hand osteoarthritis reduces a person's ability to perform work activities and return to their occupation. We investigated the effects of a finger exercise program on hand grip strength, pain, physical function, and stiffness in automobile manufacturing workers with hand osteoarthritis. This randomized controlled trial was conducted on 29 subjects. Fifteen experimental subjects received a finger exercise program with paraffin baths, while 14 control subjects received only paraffin baths. Hand grip strength, pain, physical function, and stiffness were assessed at baseline and 8 weeks later...
November 3, 2018: Hand Surgery and Rehabilitation
Antje S Mefferd, Abish Lai, Francesca Bagnato
BACKGROUND: Multiple sclerosis can affect the speech motor system and result in dysarthria. OBJECTIVES: This pilot study sought to identify tongue, lip, and jaw motor deficits in persons with dysarthria due to multiple sclerosis (PwDMS) to better understand the speech motor mechanisms that underlie their aberrant speech. METHODS: Tongue and jaw movements during "ai" and lower lip and jaw movements during "bob"were examined in eleven PwDMS and fourteen age- and sex-matched controls using three-dimensional electromagnetic articulography...
October 30, 2018: Multiple Sclerosis and related Disorders
Carla Alessandra Avila Gonzalez, Mark Driscoll, Robert Schleip, Scott Wearing, Eric Jacobson, Tom Findley, Werner Klingler
Basic sciences are the backbone of every clear understanding of how the body is composed and how different structures and functions are connected with each other. It is obvious that there is a huge variability in human beings - not only in terms of the outer appearance such as measurements of height, weight, muscle mass and other physical properties, but also with respect to metabolic and functional parameters. This article highlights recent developments of research activities in the field of fascia sciences with a special emphasis on assessment strategies as the basis of further studies...
October 2018: Journal of Bodywork and Movement Therapies
Bettina Balint, Hans-Michael Meinck
Background: Stiff person spectrum disorders (SPSD) are a group of rare conditions clinically characterized by stiffness, spasms, and heightened stimulus sensitivity. They also share a spectrum of antibodies. Methods: We reviewed the literature and our own experience with the aim of providing a practical approach to the treatment of SPSD. Results: Because of the rarity of SPSD, there is little evidence to guide treatment decisions. The treatment of SPSD is based on the triad of symptomatic treatment, immunotherapy, and tumor treatment where appropriate...
July 2018: Movement Disorders Clinical Practice
William Evans, Quentin Willey, Erik D Hanson, Lee Stoner
BACKGROUND: Arterial stiffness (AS) is a key measure in predicting risk for cardiovascular disease (CVD) and related events, independent of other risk factors. Resistance training (RT) has been shown to increase AS in young healthy subjects. However, the effects of RT on AS in persons with or at risk for CVD remain unclear; this uncertainty is a barrier to RT prescription in this population. Considering RT may be as effective as or superior to aerobic exercise prescription in treating some co-morbidities associated with CVD, it would be helpful to clarify whether RT does lead to clinically meaningful increases (detrimental) in AS in those with CVD or CVD risk factors...
December 2018: Sports Medicine
Majid Darraj
Infections caused by Mycobacterium tuberculosis (MTb) have a global distribution, with infections occurring most frequently in persons residing in or who have resided in developing nations. Pulmonary tuberculosis (Tb) is the most common form of infection caused by MTb. Osteoarticular Tb is a far less common condition than pulmonary Tb and is frequently overlooked in the differential diagnosis of persons with joint pathology. Osteoarticular Tb infections are far less common than pulmonary Tb and are usually not considered in the differential diagnosis...
2018: Case Reports in Infectious Diseases
Mario Manto, Hiroshi Mitoma, Christiane S Hampe
Anti-GAD65 antibodies (anti-GAD65 Abs) are associated with cerebellar ataxia (CA). The significance of anti-GAD65 Abs has been a focus of debates. Since GAD65 is intracellularly located and associated with type 1 diabetes mellitus and different clinical neurological phenotypes such as CA, stiff-person syndrome, and epilepsy, some researchers have argued that anti-GAD65 Abs have no pathogenic roles. On the other hand, recent physiological studies in vitro and in vivo have elucidated that binding of GAD65 by anti-GAD65 Abs elicits loss of GAD65 functions pertaining GABA release with an epitope dependence, leading to the development of CA...
October 20, 2018: Cerebellum
Marabelle L Heng, Priathashini Krishnasamy, Pui W Kong
BACKGROUND: While posterior tibial tendon dysfunction (PTTD) commonly presents with flat feet and has been thought to be associated with first ray mobility, many flat-footed individuals are asymptomatic and do not experience any symptoms of PTTD. Thus, there is a need to control for foot type when studying factors related to PTTD. This study aimed to clarify if first ray mobility differed between flat-footed individuals with and without symptoms of PTTD. It was hypothesized that PTTD patients would display higher mobility of the first ray than asymptomatic flat-footed controls...
August 3, 2018: Foot
Serkan Taş, Nilgün Bek
INTRODUCTION: Personal differences in morphological and mechanical properties of plantar fascia and heel fat pad may be an important parameter regarding an individual's balance performance. The purpose of this study was to investigate the effect of thickness and stiffness of heel fat pad and plantar fascia on balance performance in asymptomatic sedentary females. MATERIALS AND METHODS: This study was carried out on 37 asymptomatic sedentary females between the ages of 19 and 35 years...
March 1, 2018: Foot
Angela Gutermuth, Jessika Maassen, Emely Harnisch, Daniel Kuhlen, Alexis Sauer-Budge, Claudia Skazik-Voogt, Katrin Engelmann
PURPOSE: Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. Corneal transplantation is currently the only therapy for severe corneal disorders. However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells...
January 2019: Cornea
Minke C Kortekaas, Marit H N van Velzen, Frank Grüne, Sjoerd P Niehof, Robert J Stolker, Frank J P M Huygen
BACKGROUND: Vascular transit time (VTT) is the propagation time of a pulse wave through an artery; it is a measure for arterial stiffness. Because reliable non-invasive VTT measurements are difficult, as an alternative we measure pulse transit time (PTT). PTT is defined as the time between the R-wave on electrocardiogram and arrival of the resulting pulse wave in a distal location measured with photoplethysmography (PPG). The time between electrical activation of the ventricles and the resulting pulse wave after opening of the aortic valve is called the pre-ejection period (PEP), a component of PTT...
2018: PloS One
Paulo B de Freitas, Sandra M S F Freitas, Mechelle M Lewis, Xuemei Huang, Mark L Latash
The framework of the uncontrolled manifold (UCM) hypothesis was used to explore variables related to stability of task performance in the two hands of young healthy individuals. Fourteen young adults performed four-finger accurate constant force production tasks interrupted by a voluntary quick force pulse production and by an externally imposed displacement of all fingers. Three groups of variables were used to quantify stability of steady force production: (1) indices of the inter-trial variance were computed within the UCM and orthogonal to the UCM; (2) indices of motor equivalence were computed between steady-state intervals separated by the force pulse and by the finger-lifting episode; and (3) referent coordinate and apparent stiffness were computed using the data during the ascending phase of the finger-lifting episode...
October 8, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Rafaël Brouwer, Elmar Kal, John van der Kamp, Han Houdijk
BACKGROUND: A pronounced discrepancy exists between balance assessments for stroke survivors that are used for clinical purposes and those used for research. Clinical assessments like the Berg Balance Scale generally have stronger ecological validity, whereas research-based assessments like posturography are generally more reliable and precise. We developed a stabilometer balance test (SBT) that aims to couple measurement reliability and precision to clinical meaningfulness by means of a personalized and adaptive test procedure...
January 2019: Gait & Posture
Mary Ersek, Keela Herr, Michelle M Hilgeman, Moni Blazej Neradilek, Nayak Polissar, Karon F Cook, Princess Nash, A Lynn Snow, Meghan McDarby, Francis X Nelson
Objective: The goal of this study was to identify a limited set of pain indicators that were most predicive of physical pain. We began with 140 items culled from existing pain observation tools and used a modified Delphi approach followed by statistical analyses to reduce the item pool. Methods: Through the Delphi Method, we created a candidate item set of behavioral indicators. Next, trained staff observed nursing home residents and rated the items on scales of behavior intensity and frequency...
October 3, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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