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Stiff Person

Marabelle L Heng, Priathashini Krishnasamy, Pui W Kong
BACKGROUND: While posterior tibial tendon dysfunction (PTTD) commonly presents with flat feet and has been thought to be associated with first ray mobility, many flat-footed individuals are asymptomatic and do not experience any symptoms of PTTD. Thus, there is a need to control for foot type when studying factors related to PTTD. This study aimed to clarify if first ray mobility differed between flat-footed individuals with and without symptoms of PTTD. It was hypothesized that PTTD patients would display higher mobility of the first ray than asymptomatic flat-footed controls...
August 3, 2018: Foot
Serkan Taş, Nilgün Bek
INTRODUCTION: Personal differences in morphological and mechanical properties of plantar fascia and heel fat pad may be an important parameter regarding an individual's balance performance. The purpose of this study was to investigate the effect of thickness and stiffness of heel fat pad and plantar fascia on balance performance in asymptomatic sedentary females. MATERIALS AND METHODS: This study was carried out on 37 asymptomatic sedentary females between the ages of 19 and 35 years...
March 1, 2018: Foot
Angela Gutermuth, Jessika Maassen, Emely Harnisch, Daniel Kuhlen, Alexis Sauer-Budge, Claudia Skazik-Voogt, Katrin Engelmann
PURPOSE: Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. Corneal transplantation is currently the only therapy for severe corneal disorders. However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells...
October 10, 2018: Cornea
Minke C Kortekaas, Marit H N van Velzen, Frank Grüne, Sjoerd P Niehof, Robert J Stolker, Frank J P M Huygen
BACKGROUND: Vascular transit time (VTT) is the propagation time of a pulse wave through an artery; it is a measure for arterial stiffness. Because reliable non-invasive VTT measurements are difficult, as an alternative we measure pulse transit time (PTT). PTT is defined as the time between the R-wave on electrocardiogram and arrival of the resulting pulse wave in a distal location measured with photoplethysmography (PPG). The time between electrical activation of the ventricles and the resulting pulse wave after opening of the aortic valve is called the pre-ejection period (PEP), a component of PTT...
2018: PloS One
Paulo B de Freitas, Sandra M S F Freitas, Mechelle M Lewis, Xuemei Huang, Mark L Latash
The framework of the uncontrolled manifold (UCM) hypothesis was used to explore variables related to stability of task performance in the two hands of young healthy individuals. Fourteen young adults performed four-finger accurate constant force production tasks interrupted by a voluntary quick force pulse production and by an externally imposed displacement of all fingers. Three groups of variables were used to quantify stability of steady force production: (1) indices of the inter-trial variance were computed within the UCM and orthogonal to the UCM; (2) indices of motor equivalence were computed between steady-state intervals separated by the force pulse and by the finger-lifting episode; and (3) referent coordinate and apparent stiffness were computed using the data during the ascending phase of the finger-lifting episode...
October 8, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Rafaël Brouwer, Elmar Kal, John van der Kamp, Han Houdijk
BACKGROUND: A pronounced discrepancy exists between balance assessments for stroke survivors that are used for clinical purposes and those used for research. Clinical assessments like the Berg Balance Scale generally have stronger ecological validity, whereas research-based assessments like posturography are generally more reliable and precise. We developed a stabilometer balance test (SBT) that aims to couple measurement reliability and precision to clinical meaningfulness by means of a personalized and adaptive test procedure...
September 29, 2018: Gait & Posture
Mary Ersek, Keela Herr, Michelle M Hilgeman, Moni Blazej Neradilek, Nayak Polissar, Karon F Cook, Princess Nash, A Lynn Snow, Meghan McDarby, Francis X Nelson
Objective: The goal of this study was to identify a limited set of pain indicators that were most predicive of physical pain. We began with 140 items culled from existing pain observation tools and used a modified Delphi approach followed by statistical analyses to reduce the item pool. Methods: Through the Delphi Method, we created a candidate item set of behavioral indicators. Next, trained staff observed nursing home residents and rated the items on scales of behavior intensity and frequency...
October 3, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
C S Hampe, J R Radtke, A Wester, A Carlsson, E Cedervall, B Jönsson, S A Ivarsson, H Elding Larsson, K Larsson, B Lindberg, J Neiderud, O Rolandsson, Å Lernmark
AIMS: To investigate whether the N-terminal truncated glutamic acid decarboxylase 65 (GAD65) isoform is as well recognized by people with stiff person syndrome as it is by people with Type 1 diabetes, and whether conformational GAD65 antibody epitopes are displayed properly by the isoform. METHODS: GAD65 antibody-positive healthy individuals (n=13), people with stiff-person syndrome (n=15) and children with new-onset Type 1 diabetes (n=654) were analysed to determine binding to full-length GAD65 and the N-terminal truncated GAD65 isoform in each of these settings...
September 27, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
M Lehnertová, L Siudová, M Janura, Z Svoboda, J Gallo, P Kamínek
PURPOSE OF THE STUDY Knee joint is the most common place where osteoarthritis may occur. A specific therapy is indicated to patients depending on the degree of disability and other signs. The available methods and their clinical value are regularly assessed in systematic reviews and meta-analysis of clinical studies. The evidence of working mechanism of the specific therapeutic intervention is another important part of evaluating its therapy effect. One of the possibilities of knee osteoarthritis conservative treatment is a functional prophylactic knee brace...
2018: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
Mark A Supiano, Laura Lovato, Walter T Ambrosius, Jeffrey Bates, Srinivasan Beddhu, Paul Drawz, Jamie P Dwyer, Naomi M Hamburg, Dalane Kitzman, James Lash, Eva Lustigova, Cynthia M Miracle, Suzanne Oparil, Dominic S Raj, Daniel E Weiner, Addison Taylor, Joseph A Vita, Reem Yunis, Glenn M Chertow, Michel Chonchol
Arterial stiffness, typically assessed as the aortic pulse wave velocity (PWV), and central blood pressure levels may be indicators of cardiovascular disease (CVD) risk. This ancillary study to the Systolic Blood Pressure Intervention Trial (SPRINT) obtained baseline assessments (at randomization) of PWV and central systolic blood pressure (C-SBP) to: 1) characterize these vascular measurements in the SPRINT cohort, and 2) test the hypotheses that PWV and C-SBP are associated with glucose homeostasis and markers of chronic kidney disease (CKD)...
2018: PloS One
Vincent Marot, Jérôme Murgier, Alessandro Carrozzo, Nicolas Reina, Edoardo Monaco, Philippe Chiron, Emilie Berard, Etienne Cavaignac
PURPOSE: The KOOS questionnaire is used to assess the symptoms and function of patients with traumatic or degenerative knee pathology. The WOMAC score has been validated mainly in the context of knee osteoarthritis. The distribution of these scores in a non-diseased population is not known. The hypothesis was that KOOS and WOMAC scores were influenced by patients' age, sex, and BMI. The primary objective of this study was to describe, for the first time, the distribution of KOOS and WOMAC scores in a healthy population based on age, sex, and BMI...
September 24, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Michał T Kuszewski, Rafał Gnat, Grzegorz Szlachta, Magdalena Kaczyńska, Andrzej Knapik
OBJECTIVES: The aim of the article is to investigate the passive stiffness (PS) of rectus femoris and hamstring muscles working for the knee joint in persons after anterior cruciate ligament (ACL) reconstruction surgery. METHODS: Thirty subjects (8 women and 22 men) aged 19-46 (x = 28.2 ± 7) participated in the investigation; an experimental group comprised 15 persons (4 women and 11 men) who underwent ACL reconstruction surgery. The other persons had no knee injury and described themselves as healthy...
September 24, 2018: Physician and Sportsmedicine
Linxiao Wu, Jatinder Virdee, Elizabeth Maughan, Arnold Darbyshire, Gavin Jell, Marilena Loizidou, Mark Emberton, Peter Butler, Ashley Howkins, Alan Reynolds, Ian W Boyd, Martin Birchall, Wenhui Song
Cell and tissue stiffness is an important biomechanical signalling parameter for dynamic biological processes; responsive polymeric materials conferring responsive functionality are therefore appealing for in vivo implants. We have developed thermoresponsive poly(urea-urethane) nanohybrid scaffolds with 'stiffness memory' through a versatile 3D printing-guided thermally induced phase separation (3D-TIPS) technique. 3D-TIPS, a combination of 3D printing with phase separation, allows uniform phase-separation and phase transition of the polymer solution at a large interface of network within the printed sacrificial preform, leading to the creation of full-scale scaffolds with bespoke anatomical complex geometry...
September 15, 2018: Acta Biomaterialia
Jonathan R Galli, Sharon D Austin, John E Greenlee, Stacey L Clardy
INTRODUCTION: Stiff Person Syndrome (SPS) is a neurological disorder characterized by muscle rigidity primarily in the truncal muscles, commonly associated with autoantibodies to the glutamic acid-decarboxylase 65 kD receptor (GAD65). There is limited epidemiological information on patients with SPS. METHODS: We performed a retrospective case review utilizing the National United States Veterans Affairs Health Administration electronic medical record system. We analyzed prevalence, demographics, disease characteristics, and treatment outcomes in anti-GAD65 antibody positive SPS patients...
September 7, 2018: Muscle & Nerve
Natascha Schaefer, Vera Roemer, Dieter Janzen, Carmen Villmann
Ionotropic glycine receptors (GlyRs) enable fast synaptic neurotransmission in the adult spinal cord and brainstem. The inhibitory GlyR is a transmembrane glycine-gated chloride channel. The immature GlyR protein undergoes various processing steps, e.g., folding, assembly, and maturation while traveling from the endoplasmic reticulum to and through the Golgi apparatus, where post-translational modifications, e.g., glycosylation occur. The mature receptors are forward transported via microtubules to the cellular surface and inserted into neuronal membranes followed by synaptic clustering...
2018: Frontiers in Molecular Neuroscience
Li-Ya Tang, Sheng-Yuan Yu, Yong-Hua Huang
We reported a Stiff person syndrome (SPS) patient with elevated autoantibodies against cardiolipin and β2 glycoprotein 1 but without glutamic acid decarboxylase (GAD) antibodies. A 40-year male was admitted due to limited mouth opening for 1 week. His blood routine, biochemical, infectious diseases, tumor markers, radiographic examinations were all normal. At day 3 (D3) after admission, he developed paroxysmal systemic muscle rigidity. At D6, the on-duty physician occasionally gave oral clonazepam, which effectively relieved the symptom...
September 1, 2018: Journal of Musculoskeletal & Neuronal Interactions
Ahmet Ozyigit, Costas Michaelides, Konstantinos Natsiopoulos
Spontaneous intracranial hypotension (SIH) is a rare and often underdiagnosed condition, which commonly results from a cerebrospinal fluid leak. The classic clinical presentation of SIH is a postural headache and dizziness. Less frequent complications include nausea, neck stiffness, and even coma. This case report describes a 70-year-old woman with an initial complaint of postural headaches and sleep attacks, who developed a 22-month progressive history of personality and behavioral changes, cognitive decline, urinary incontinence, chorea, and dysarthria...
2018: Frontiers in Neurology
Asier de Albóniga-Chindurza, Elena Riva, Adolfo Jiménez-Huete, Francesc Graus, Oriol Franch
The stiff person syndrome is a rare neurological disorder, difficult to diagnose and to treat. Paraneoplastic patients usually present amphiphysin antibodies but the association with anti-Ri antibodies is less known. We present a case report of paraneoplastic SPS, small cell carcinoma of the bladder and anti-Ri antibodies.
October 2018: Clinical Neurology and Neurosurgery
Daniel Feldman, Jorge Otero-Millan, Aasef G Shaikh
An autoimmune disorder of the central nervous system, stiff person syndrome, frequently presents with increased titers of 65KD anti-glutamic acid decarboxylase (anti-GAD) antibodies. The clinical phenomenology of this syndrome includes stiffness, ataxia, vertigo due to horizontal gaze-evoked and downbeat vertical nystagmus, and dysmetria of saccades and reaching movements. Here, we describe a novel phenomenology of syndrome of anti-GAD antibody, non-position-dependent upbeat nystagmus and superimposed horizontal gaze-evoked nystagmus...
August 22, 2018: Cerebellum
James A G Crispo, Dylan P Thibault, Yannick Fortin, Allison W Willis
Background: Stiff person syndrome (SPS) is a progressive neurological disorder characterized by axial muscle rigidity and involuntary spasms. Autoimmune and neoplastic diseases are associated with SPS. Our study objectives were to describe inpatient care for SPS in the United States and characterize 30-day readmissions. Methods: We queried the 2014 Nationwide Readmission Database for hospitalizations where a diagnosis of SPS was recorded. For readmission analyses, we excluded encounters with missing length of stay, hospitalization deaths, and out-of-state and December discharges...
2018: Journal of Clinical Movement Disorders
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