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Stiff Person

Erik H Hofmeister, Michele Barletta, Molly Shepard, Benjamin M Brainard, Cynthia M Trim, Jane Quandt
OBJECTIVE: To establish evidence for the validity and reliability of three commonly used pain scales in dogs when assessed by video by specialists in anesthesia. STUDY DESIGN: Mixed-method test-retest observational study. SUBJECTS: A group of six American College of Veterinary Anesthesia and Analgesia board-certified specialists and 31 postoperative dogs. METHODS: The evaluators scored 31 dogs using a visual analogue scale (VAS), numeric rating scale (NRS), and Glasgow pain scale (GPS)...
May 22, 2018: Veterinary Anaesthesia and Analgesia
Audrey Dillon, Zita Galvin, Alyshah A Sultan, David Harman, Indra N Guha, Stephen Stewart
BACKGROUND: Compensated cirrhosis has a variable prognosis depending on stage. There are currently no straightforward and robust tools in clinical practice to predict decompensation in Child-Pugh A cirrhosis. We set out to determine whether transient elastography (TE) could be used across liver disease aetiologies to determine risk of decompensation. PATIENTS AND METHODS: Participants were enrolled at two sites (Dublin and Nottingham) and followed up for a minimum of 2 years...
July 30, 2018: European Journal of Gastroenterology & Hepatology
Çağla Aydin, Şenay Yıldız Çelik, Sema İçöz, Canan Ulusoy, Tuncay Gündüz, Gülşen Akman Demir, Murat Kürtüncü, Erdem Tüzün
Introduction: Anti-neuronal antibodies (ANA) are found in paraneoplastic neurological syndrome and autoimmune encephalitis patients. Our aim was to analyze prognostic factors related with ANA seropositivity. Methods: Twenty-seven consecutive ANA seropositive patients were included in the study. ANA were detected by immunofluorescent staining, immunoblot and cell-based assay methods. All patients were followed with a standard treatment protocol. Clinical syndromes, tumor types, modified Rankin scores, cranial MRI and oligoclonal band (OCB) findings were recorded...
2018: Noro Psikiyatri Arsivi
Tommaso Schirinzi, Andrea Sancesario, Alberto Romano, Martina Favetta, Marina Gobbi, Massimiliano Valeriani, Enrico S Bertini, Enrico Castelli, Gessica Vasco, Maurizio Petrarca, Gessica Della Bella
Stiff person syndrome (SPS) is an autoimmune disorder with multiple clinical presentations, all characterized by generalized or focal muscular stiffness leading to abnormal postures and movements. To date, no standardized treatments are available; also, the outcome measures are mainly clinical based and unstandardized, limiting the reliability of clinical trials. In this case study, we used the eight-camera motion capture system for gait analysis (GA) to outline the gait features and track the clinical evolution of a young patient with SPS receiving a personalized multimodal therapy...
July 24, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
Jasmijn F M Holla, Marian H van Beers-Tas, Lotte A van de Stadt, Robert Landewé, Jos W R Twisk, Joost Dekker, Dirkjan van Schaardenburg
Objective: Studies on the role of psychosocial vulnerability in the development of arthritis must be performed early in the disease course to exclude the reverse explanation that arthritis leads to psychological symptoms. Therefore, the objective of this study was to investigate the longitudinal (5-year) association between depressive mood, daily stressors, avoidance coping and social support as predictors, and the development of arthritis and other clinical parameters as outcomes, in persons with seropositive arthralgia at risk of developing rheumatoid arthritis...
2018: RMD Open
Juhyun Song, So Ra Yoon, Oh Yoen Kim
Background: Low adiponectin levels are associated with increased insulin resistance (IR) and arterial stiffness in hypertensive patients, but higher adiponectin levels are also found in heart failure patients. This discrepancy has not been fully resolved, but it may be related to the adiponectin gene ( ADIPOQ ) which regulates adiponectin production. We aimed to investigate whether the relationship between adiponectin and arterial stiffness is associated with ADIPOQ rs1501299 G/T polymorphism in nondiabetic Korean men...
2018: Diabetology & Metabolic Syndrome
Kazuhiro Horiuchi, Yasunori Maruo, Satomi Matsuoka
We herein report the case of stiff-person syndrome in a 73-year-old woman. She experienced episodes of painful muscle spasms and was admitted to another hospital. She was diagnosed with Waldenström macroglobulinemia. She showed improvement in muscle spasms post-chemotherapy, which was discontinued due to pancytopenia. Six months later, she was admitted to our hospital for repeated whole-body muscle spasms, at which point she was diagnosed with stiff-person syndrome. An anti-glutamic acid decarboxylase antibody text was negative...
July 6, 2018: Internal Medicine
Hooman Khorshidi, Pardis Haddadi, Saeed Raoofi, Parisa Badiee, Ali Dehghani Nazhvani
Objectives: Leucocyte- and platelet-rich fibrin (L-PRF) membrane can be used in various regenerative treatments. In the case of classical heterologous membrane exposure, microorganisms can be colonized on it and jeopardize the success of treatment. The aim of this study was to compare the antibacterial, mechanical, and histologic characteristics of the L-PRF membrane before and after the addition of silver nanoparticles (SNP). Materials and Method: This study was performed on 10 volunteer men aged 25-35 years...
2018: BioMed Research International
Zameer Mohamed, John Rwegasha, Jin U Kim, Yusuke Shimakawa, Lila Poiteau, Stéphane Chevaliez, Sanjay Bhagani, Simon D Taylor-Robinson, Mark R Thursz, Jessie Mbwambo, Maud Lemoine
The World Health Organisation has recently called for hepatitis C virus (HCV) elimination and has identified people who inject drugs (PWID) as a key population to scale-up screening and linkage to care. This study reports the cascade of care for HCV in PWID attending the largest opioid substitution treatment (OST) clinic in Dar-es-Salaam, Tanzania. Between February 2011 and March 2016, HCV serology for all PWID registered at the Muhimbili National Hospital OST clinic, Dar-es-Salaam were obtained from records...
July 3, 2018: Journal of Viral Hepatitis
Ruoli Wang, Johan Gäverth, Pawel A Herman
Quantifying neural and non-neural contributions to the joint resistance in spasticity is essential for a better evaluation of different intervention strategies such as botulinum toxin A (BoTN-A). However, direct measurement of muscle mechanical properties and spasticity-related parameters in humans is extremely challenging. The aim of this study was to use a previously developed musculoskeletal model and optimization scheme to evaluate the changes of neural and non-neural related properties of the spastic wrist flexors during passive wrist extension after BoTN-A injection...
2018: Frontiers in Bioengineering and Biotechnology
Shao-Hsien Liu, Catherine E Dubé, Charles B Eaton, Jeffrey B Driban, Timothy E McAlindon, Kate L Lapane
OBJECTIVE: We examined the longterm effectiveness of corticosteroid or hyaluronic acid injections in relieving symptoms among persons with knee osteoarthritis (OA). METHODS: Using Osteoarthritis Initiative data, a new-user design was applied to identify participants initiating corticosteroid or hyaluronic acid injections (n = 412). Knee symptoms (pain, stiffness, function) were measured using The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)...
June 15, 2018: Journal of Rheumatology
Pingqiang Cai, Benhui Hu, Wan Ru Leow, Xiaoyuan Wang, Xian Jun Loh, Yun-Long Wu, Xiaodong Chen
The reciprocal mechanical interaction of engineered materials with biointerfaces have long been observed and exploited in biomedical applications. It contributes to the rise of biomechano-responsive materials and biomechano-stimulatory materials, constituting the biomechano-interactive interfaces. Here, endogenous and exogenous biomechanical stimuli available for mechanoresponsive interfaces are briefed and their mechanistic responses, including deformation and volume change, mechanomanipulation of physical and chemical bonds, dissociation of assemblies, and coupling with thermoresponsiveness are summarized...
June 7, 2018: Advanced Materials
Eun Sun Yoon, Kevin S Heffernan, Sae Young Jae, Hyun Jeong Kim, Kanokwan Bunsawat, Bo Fernhall
OBJECTIVE: Despite preserved metabolic function, metabolically healthy obesity may increase the risk of subclinical atherosclerosis. Given the high prevalence of cardiometabolic diseases in individuals with spinal cord injury, the aim of this study was to investigate the association of insulin resistance, systemic low-grade inflammation, and markers of subclinical atherosclerosis with metabolically healthy obesity in individuals with spinal cord injury. METHODS: Insulin resistance index (HOMA-IR), high-sensitivity C-reactive protein, carotid artery intima-media thickness and carotid-femoral pulse wave velocity were measured in individuals with spinal cord injury classified with metabolically healthy obesity (n = 12), metabolically unhealthy obesity (n = 8), or metabolically healthy normal-weight (n = 18)...
July 17, 2018: Journal of Rehabilitation Medicine
Marian H van Beers-Tas, Marieke M Ter Wee, Lilian H van Tuyl, Bertha Maat, Wijnanda Hoogland, Aase H Hensvold, Anca I Catrina, Erika Mosor, Tanja A Stamm, Axel Finckh, Delphine S Courvoisier, Andrew Filer, Ilfita Sahbudin, Rebecca J Stack, Karim Raza, Dirkjan van Schaardenburg
Objectives: To describe the development and assess the psychometric properties of the novel 'Symptoms in Persons At Risk of Rheumatoid Arthritis' (SPARRA) questionnaire in individuals at risk of rheumatoid arthritis (RA) and to quantify their symptoms. Methods: The questionnaire items were derived from a qualitative study in patients with seropositive arthralgia. The questionnaire was administered to 219 individuals at risk of RA on the basis of symptoms or autoantibody positivity: 74% rheumatoid factor and/or anticitrullinated protein antibodies positive, 26% seronegative...
2018: RMD Open
Łukasz Paluch, Bartłomiej Noszczyk, Żaneta Nitek, Jerzy Walecki, Katarzyna Osiak, Piotr Pietruski
OBJECTIVES: The primary aim of this study was to verify if shear-wave elastography (SWE) can be used to diagnose ulnar neuropathy at the elbow (UNE). The secondary objective was to compare the cross-sectional areas (CSA) of the ulnar nerve in the cubital tunnel and to determine a cut-off value for this parameter accurately identifying persons with UNE. METHODS: The study included 34 patients with UNE (mean age, 59.35 years) and 38 healthy controls (mean age, 57...
June 1, 2018: European Radiology
Juntaro Kaneko, Naomi Kanazawa, Naomi Tominaga, Atsushi Kaneko, Hiroki Suga, Ryo Usui, Daisuke Ishima, Eiji Kitamura, Tsugio Akutsu, Koji Yoshida, Kazutoshi Nishiyama, Takahiro Iizuka
OBJECTIVES: To address practical issues in measuring autoantibodies to neuronal cell-surface antigens (NSAs) in various autoimmune neurological disorders (ANDs). METHODS: We retrospectively reviewed the clinical information of 221 patients with clinically suspected ANDs who underwent antibody testing for NSAs between January 2007 and September 2017. 31 were excluded. In 190 patients, antibody-detection rate (ADR) and antibody-phenotype association were assessed...
July 15, 2018: Journal of the Neurological Sciences
Chieri Takahashi, Tadashi Suga, Hiromasa Ueno, Yuto Miyake, Mitsuo Otsuka, Masafumi Terada, Akinori Nagano, Tadao Isaka
OBJECTIVE: To investigate the relationship between passive planter flexor stiffness and sprint performance in sprinters. DESIGN: Cross-sectional study. PARTICIPANTS: Fifty well-trained male sprinters (age: 20.7 ± 1.9 years, height: 175.6 ± 4.9 cm, weight: 66.7 ± 5.1 kg) were participated in this study. Their best personal times in a 100-m sprint ranged from 10.22 to 11.86 s (mean, 11.12 ± 0.43 s). METHODS: Passive stiffness of the plantar flexors measured using a dynamometer system...
July 2018: Physical Therapy in Sport
Mohammad Hadi Gharedaghi, Arjang Khorasani, Nebojsa Nick Knezevic, Farzad Ebrahimi
Stiff-person syndrome (SPS) and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis are rare paraneoplastic syndromes caused by antibodies that target the central nervous system. Here, we describe a 26-year-old woman who presented with psychosis, amnesia, rigidity and fever. After extensive diagnostic and laboratory workup, she was diagnosed with an ovarian teratoma which was causing the symptoms of anti-NMDAR encephalitis and SPS. The patient was successfully treated with laparoscopic removal of the ovarian tumour under general anaesthesia...
May 7, 2018: BMJ Case Reports
Hiroshi Kumagai, Toru Yoshikawa, Kanae Myoenzono, Keisei Kosaki, Nobuhiko Akazawa, Zempo-Miyaki Asako, Takehiko Tsujimoto, Tetsuhiro Kidokoro, Kiyoji Tanaka, Seiji Maeda
BACKGROUND: As arterial stiffness increases in the absence of subjective symptoms, a personal indicator that reflects increased risk of cardiovascular disease is necessary. Penile erection is regulated by vascular function, and atherosclerosis affects the penile artery earlier than it affects the coronary and carotid arteries. Therefore, we hypothesized that deterioration of erectile function could be a marker of increased risk for cardiovascular disease. To test our hypothesis, we assessed erectile function and arterial stiffness in a cross-sectional study...
May 5, 2018: Journal of the American Heart Association
Taina Rantanen, Milla Saajanaho, Laura Karavirta, Sini Siltanen, Merja Rantakokko, Anne Viljanen, Timo Rantalainen, Katja Pynnönen, Anu Karvonen, Inna Lisko, Lotta Palmberg, Johanna Eronen, Eeva-Maija Palonen, Timo Hinrichs, Markku Kauppinen, Katja Kokko, Erja Portegijs
BACKGROUND: Population aging increases the need for knowledge on positive aspects of aging, and contributions of older people to their own wellbeing and that of others. We defined active aging as an individual's striving for elements of wellbeing with activities as per their goals, abilities and opportunities. This study examines associations of health, health behaviors, health literacy and functional abilities, environmental and social support with active aging and wellbeing. We will develop and validate assessment methods for physical activity and physical resilience suitable for research on older people, and examine their associations with active aging and wellbeing...
May 2, 2018: BMC Public Health
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