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cocain toxicity treatment

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https://www.readbyqxmd.com/read/30283033/cocaine-induced-ischemia-in-prefrontal-cortex-is-associated-with-escalation-of-cocaine-intake-in-rodents
#1
Congwu Du, Nora D Volkow, Jiang You, Kicheon Park, Craig P Allen, George F Koob, Yingtian Pan
Cocaine-induced vasoconstriction reduces blood flow, which can jeopardize neuronal function and in the prefrontal cortex (PFC) it may contribute to compulsive cocaine intake. Here, we used integrated optical imaging in a rat self-administration and a mouse noncontingent model, to investigate whether changes in the cerebrovascular system in the PFC contribute to cocaine self-administration, and whether they recover with detoxification. In both animal models, cocaine induced severe vasoconstriction and marked reductions in cerebral blood flow (CBF) in the PFC, which were exacerbated with chronic exposure and with escalation of cocaine intake...
October 3, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/30255497/antineutrophil-cytoplasmic-antibodies-negative-levamisole-induced-leukocytoclastic-vasculitis-a-presumed-case-and-literature-review
#2
Daniel Kunzler, Lauren Lagrimas, Thiennga Vo, Andrew DeCrescenzo, Kyle Kaltwasser, Janice Wilson
Levamisole-contaminated cocaine toxicity is a serious emerging public health concern, and providers should be aware of its presentation and management. Most cases of levamisole-induced vasculitis/vasculopathy (LIV) are associated with high antineutrophil cytoplasmic antibodies (ANCA). We describe a unique case of a cocaine user who presented with an acute purpuric eruption and negative ANCA laboratory findings. A brief clinical overview of LIV, spanning from patient presentation to treatment, is provided. In addition, we present a summary of all cases of ANCA-negative vasculitis identified via a PubMed literature review...
September 25, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/30245987/differentiation-of-cocaine-induced-midline-destructive-lesions-from-anca-associated-vasculitis
#3
Alireza Mirzaei, Mozhdeh Zabihiyeganeh, Ala Haqiqi
Introduction: Cocaine-induced midline destructive lesions (CIMDL) are complications of regular nasal cocaine inhalation. CIMDL can mimic systemic diseases with positive anti-neutrophil cytoplasmic antibodies (ANCA), such as granulomatosis with polyangiitis (GPA). Case Report: In this article, we describe the case of a young woman who presented with nasal perforation induced by cocaine, along with positive perinuclear ANCA test (proteinase 3 antigen), misdiagnosed as limited GPA...
September 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/30180803/a-patient-full-of-surprises-a-body-packer-with-cocaine-intoxication-pneumococcal-pneumonia-and-hiv-infection
#4
Miriam Luginbühl, Timo Junker, Dagmar I Keller
BACKGROUND: Smuggling of illegal drugs by hiding them inside one's own body, also called body packing, is a worldwide phenomenon. Cocaine is the most frequently transported drug. Body packing is a potentially lethal practice. The most serious complications of body packing are gastrointestinal obstruction or perforation and drug toxicity due to packet leakage or rupture. CASE PRESENTATION: A 30-year-old confirmed body packer was brought to our emergency department from jail because of agitation and mydriasis...
September 4, 2018: BMC Emergency Medicine
https://www.readbyqxmd.com/read/30126647/cocaine-alters-the-mouse-testicular-epigenome-with-direct-impact-on-histone-acetylation-and-dna-methylation-marks
#5
Betina González, Camilo R Gambini Pantoja, Maximo H Sosa, Alfredo D Vitullo, Verónica Bisagno, Candela R González
RESEARCH QUESTION: Recent evidence suggests that cocaine administration in animal models can trigger non-genetic inheritance of addiction traits from father to offspring, affecting development and behaviour. Is chronic cocaine intake involved in alterations of epigenetic homeostasis in the testis? DESIGN: Epigenetic marks and mediators in testis and isolated germ cells of adult mice treated with cocaine (10 mg/kg) or vehicle (sterile saline solution) were evaluated in an intermittent binge protocol: three intraperitoneal injections, 1 h apart, one day on/off for 13 days, collecting tissue 24 h after the last binge administration (day 14)...
September 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/30066173/alterations-in-the-gut-microbiota-of-rats-chronically-exposed-to-volatilized-cocaine-and-its-active-adulterants-caffeine-and-phenacetin
#6
Cecilia Scorza, Claudia Piccini, Marcela Martínez Busi, Juan Andrés Abin Carriquiry, Pablo Zunino
A role of the gut microbiota in influencing brain function and emotional disorders has been suggested. However, only a few studies have investigated the gut microbiota in the context of drug addiction.Cocaine can be smoked (i.e., crack or coca paste) and its consumption is associated with a very high abuse liability and toxicity. We have recently reported that cocaine base seized samples contained caffeine and phenacetin as main active adulterants, which may potentiate its motivational, reinforcing, and toxic effects...
July 31, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29846769/ethanol-addictively-enhances-the-in-vitro-cardiotoxicity-of-cocaine-through-oxidative-damage-energetic-deregulation-and-apoptosis
#7
Maria João Martins, Rita Roque Bravo, Maria Enea, Helena Carmo, Félix Carvalho, Maria de Lourdes Bastos, Ricardo Jorge Dinis-Oliveira, Diana Dias da Silva
Cocaine (COC) is frequently consumed in polydrug abuse settings, and ethanol (EtOH) is the most prominent co-abused substance. Clinical data and experimental evidence suggest that the co-administration of COC with EtOH can be more cardiotoxic than EtOH or COC alone, but information on the molecular pathways involved is scarce. Since these data are crucial to potentiate the identification of therapeutic targets to treat intoxications, we sought to (i) elucidate the type of interaction that occurs between both substances, and (ii) assess the mechanisms implicated in the cardiotoxic effects elicited by COC combined with EtOH...
July 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29807217/tv-1380-attenuates-cocaine-induced-changes-in-cardiodynamic-parameters-in-monkeys-and-reduces-the-formation-of-cocaethylene
#8
Liron Shemesh-Darvish, Doron Shinar, Hussein Hallak, Aviva Gross, Moti Rosenstock
BACKGROUND: TV-1380 is a rationally mutated, human BChE fused to human serum albumin that has high hydrolytic enzymatic activity against cocaine and as well as an extended elimination half-life. OBJECTIVE: The present studies examined the safety of TV-1380 and its protective effect when given to monkeys alone or concomitantly with cocaine and ethanol. METHODS: A set of studies was conducted in monkeys with TV-1380. The parameters tested included telemetric assessment of cardiovascular parameters, clinical pathology, plasma analysis of cardiac troponin I, ex-vivo analyses of cocaethylene and PK analysis of serum concentrations of TV-1380, cocaine and its metabolites, and histopathological examinations...
July 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29582960/-acute-kidney-injury-and-rhabdomyolysis-after-cocaine-overdose-case-report-and-literature-review
#9
REVIEW
Anna Mudoni, Francesco Caccetta, Maurizio Caroppo, Fernando Musio, Antonella Accogli, Maria Dolores Zacheo, Maria Domenica Burzo, Vitale Nuzzo
Cocaine, a natural alkaloid derived from the coca plant, is one of the most commonly used illicit drugs. Cocaine abuse causes systemic adverse effects like stroke, myocardic infarction, arterial dissection, vascular thrombosis and rhabdomyolysis. Cocaine use is, also, associated with renal complications such as acute kidney injury, vasculitis, acute interstitial nephritis, chronic kidney disease, malignant hypertension with thrombotic microangiopathy. Acute kidney injury may or may be not associated to rhabdomyolysis...
March 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29577963/dopamine-d1-and-d3-receptor-polypharmacology-as-a-potential-treatment-approach-for-substance-use-disorder
#10
REVIEW
Ewa Galaj, Scott Ewing, Robert Ranaldi
In the search for efficacious pharmacotherapies to treat cocaine addiction much attention has been given to agents targeting dopamine D1 or D3 receptors because of the involvement of these receptors in drug-related behaviors. D1-like and D3 receptor partial agonists and antagonists have been shown to reduce drug reward, reinstatement of drug seeking and conditioned place preference in rodents and non-human primates. However, translation of these encouraging results to clinical settings has been limited due to a number of factors including toxicity, poor pharmacokinetic properties and extrapyramidal and sedative side effects...
June 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29475069/in-vitro-model-to-study-cocaine-and-its-contaminants
#11
Aline Steinmetz, Luiza Steffens, Ana Moira Morás, Flávia Prezzi, Elizandra Braganhol, Jenifer Saffi, Rafael Scorsatto Ortiz, Helena M T Barros, Dinara Jaqueline Moura
Cocaine is one of the most popular illicit drug worldwide. Due its great addictive potential, which leads to euphoria and hyperactivity, it is considered a public health concern. At the central nervous system, the drug acts inhibiting catecholamine re-uptake. It is now known that in addition to the toxicity of the drug itself, the contaminants present in the street drug have raised concern about the harmful effects on health. Toxicological in vivo and in vitro studies have demonstrated the toxic effects of cocaine correlated with the generation of reactive oxygen species (ROS), which in turn lead to oxidative damage to the cells...
April 1, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29427992/apple-condom-and-cocaine-body-stuffing-in-prison-a-case-report
#12
Benedicte Jalbert, Nguyen Toan Tran, Stephan von Düring, Pierre-Alexandre Poletti, Ian Fournier, Catherine Hafner, Celestine Dubost, Laurent Gétaz, Hans Wolff
BACKGROUND: Drug dealers and drug users resort to body stuffing to hastily conceal illicit drugs by ingesting their drug packets. This practice represents a medical challenge because rupture of the often insecure packaging can be toxic and even lethal. In an emergency setting, official guidelines are needed to help the medical team decide on the proper treatment. A preliminary observation period is generally accepted but its duration varies from hours to eventual packet expulsion. CASE PRESENTATION: This case involves a 20-year-old white man in detention who claimed to have ingested one cocaine packet wrapped in plastic food-wrap and a condom in anticipation of an impending cell search...
February 11, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29426863/identification-of-biochemical-and-cytotoxic-markers-in-cocaine-treated-pc12-cells
#13
Ramesh B Badisa, Chyree S Batton, Elizabeth Mazzio, Samuel C Grant, Carl B Goodman
Cocaine is one of the powerful addictive drugs, widely abused in most Western countries. Because of high lipophilic nature, cocaine easily reaches various domains of the central nervous system (CNS) and triggers different levels of cellular toxicity. The aim of this investigation was to reproduce cocaine toxicity in differentiated PC12 cells through quantitative knowledge on biochemical and cytotoxicity markers. We differentiated the cells with 0.1 μg/ml nerve growth factor (NGF) for 5 days, followed by treatment with cocaine for 48 h at in vivo and in vitro concentrations...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29381909/metoprolol-treatment-of-dual-cocaine-and-bupropion-cardiovascular-and-central-nervous-system-toxicity
#14
John R Richards, Jessica B Gould, Erik G Laurin, Timothy E Albertson
Cardiovascular and central nervous system (CNS) toxicity, including tachydysrhythmia, agitation, and seizures, may arise from cocaine or bupropion use. We report acute toxicity from the concomitant use of cocaine and bupropion in a 25-year-old female. She arrived agitated and uncooperative, with a history of possible antecedent cocaine use. Her electrocardiogram demonstrated tachycardia at 130 beats/min, with a corrected QT interval of 579 ms. Two doses of 5 mg intravenous metoprolol were administered, which resolved the agitation, tachydysrhythmia, and corrected QT interval prolongation...
January 31, 2018: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29350320/ethical-implications-in-vaccine-pharmacotherapy-for-treatment-and-prevention-of-drug-of-abuse-dependence
#15
Anna Carfora, Paola Cassandro, Alessandro Feola, Francesco La Sala, Raffaella Petrella, Renata Borriello
Different immunotherapeutic approaches are in the pipeline for the treatment of drug dependence. "Drug vaccines" aim to induce the immune system to produce antibodies that bind to drugs and prevent them from inducing rewarding effects in the brain. Drugs of abuse currently being tested using these new approaches are opioids, nicotine, cocaine, and methamphetamine. In human clinical trials, "cocaine and nicotine vaccines" have been shown to induce sufficient antibody levels while producing few side effects...
March 2018: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/29315692/comprehensive-review-of-cardiovascular-toxicity-of-drugs-and-related-agents
#16
REVIEW
Přemysl Mladěnka, Lenka Applová, Jiří Patočka, Vera Marisa Costa, Fernando Remiao, Jana Pourová, Aleš Mladěnka, Jana Karlíčková, Luděk Jahodář, Marie Vopršalová, Kurt J Varner, Martin Štěrba
Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases...
July 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29185916/drug-drug-interactions-in-cocaine-users-and-their-clinical-implications
#17
REVIEW
Luca Gallelli, Santo Gratteri, Antonio Siniscalchi, Erika Cione, Sabrina Sirico, Paolo Seminara, Maria Cristina Caroleo, Giovambattista De Sarro
BACKGROUND: Drug-Drug Interactions (DDIs) represent a common problem in clinical practice during drug treatments. DDIs can both induce the development of adverse drug reactions or reduce the clinical efficacy of each drug. OBJECTIVES: The main objective of this review was to analyze the pharmacokinetic and pharmacodynamic DDIs in cocaine consumers, focusing the interest on their clinical implications. METHODS: The PubMed, Embase and Cochrane library databases were searched for articles published until January 10, 2017...
2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/29181644/effectiveness-of-a-cocaine-hydrolase-for-cocaine-toxicity-treatment-in-male-and-female-rats
#18
Xirong Zheng, Ziyuan Zhou, Ting Zhang, Zhenyu Jin, Xiabin Chen, Jing Deng, Chang-Guo Zhan, Fang Zheng
Development of a truly effective medication for treatment of cocaine abuse has been a grand challenge. There is no FDA-approved therapeutic agent specific for cocaine addiction or overdose. An enzyme therapy using an efficient cocaine-metabolizing enzyme could be a promising treatment strategy for cocaine overdose and addiction. One of our previously designed cocaine hydrolases (CocHs), known as CocH1, was fused with human serum albumin (HSA) to prolong the biological half-life. The fusion protein CocH1-HSA is an investigational new drug (IND) approved by the FDA for clinical trials in cocaine addiction treatment, but not in cocaine overdose/toxicity treatment...
November 27, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29127295/clinical-potential-of-an-enzyme-based-novel-therapy-for-cocaine-overdose
#19
Ting Zhang, Xirong Zheng, Ziyuan Zhou, Xiabin Chen, Zhenyu Jin, Jing Deng, Chang-Guo Zhan, Fang Zheng
It is a grand challenge to develop a truly effective medication for treatment of cocaine overdose. The current available, practical emergence treatment for cocaine overdose includes administration of a benzodiazepine anticonvulsant agent (e.g. diazepam) and/or physical cooling with an aim to relieve the symptoms. The inherent difficulties of antagonizing physiological effects of drugs in the central nervous system have led to exploring protein-based pharmacokinetic approaches using biologics like vaccines, monoclonal antibodies, and enzymes...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29123854/local-anesthetic-toxicity-acute-and-chronic-management
#20
REVIEW
Kenichi Sekimoto, Masaru Tobe, Shigeru Saito
Local anesthetics are commonly used medicines in clinical settings. They are used for pain management during minor interventional treatments, and for postoperative care after major surgeries. Cocaine is the well-known origin of local anesthetics, and the drug and related derivatives have long history of clinical usage for more than several centuries. Although illegal use of cocaine and its abuse are social problem in some countries, other local anesthetics are safely and effectively used in clinics and hospitals all over the world...
April 2017: Acute Medicine & Surgery
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