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Isavuconazole in childrens

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https://www.readbyqxmd.com/read/30039238/isavuconazole-in-a-successful-combination-treatment-of-disseminated-mucormycosis-in-a-child-with-acute-lymphoblastic-leukaemia-and-generalized-haemochromatosis-a-case-report-and-review-of-the-literature
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Anna Pomorska, Anna Malecka, Radoslaw Jaworski, Julia Radon-Proskura, Rasmus Kr√łger Hare, Henrik Vedel Nielsen, Lee O'Brian Andersen, Henrik Elvang Jensen, Maiken Cavling Arendrup, Ninela Irga-Jaworska
Invasive mucormycosis in immunocompromised children is a life-threatening fungal infection. We report a case of a 7-year-old girl treated for acute lymphoblastic leukaemia complicated by disseminated mucormycosis during induction therapy. Microscopic examination of surgically removed lung tissue revealed wide, pauci-septate hyphae suggesting a Mucorales infection. This diagnosis was confirmed immunohistochemically and by PCR analysis followed by a final identification of Cunninghamella sp. The patient was treated successfully with surgical debridement and antifungal combination therapy with amphotericin B, caspofungin and isavuconazole...
July 23, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29932282/successful-treatment-of-invasive-mucormycosis-with-isavuconazole-in-pediatric-patients
#2
Assaf A Barg, Sarah Malkiel, Maya Bartuv, Gahl Greenberg, Amos Toren, Nathan Keller
BACKGROUND: Invasive mold infections (IMIs) are a leading cause of mortality among immunocompromised patients. Isavuconazole is a new drug that shows promise in the adult population for the treatment of IMIs. No data regarding the use of isavuconazole in pediatric patients have been published. METHODS: Patients with a diagnosis of IMI from our pediatric hemato-oncology division, treated with isavuconazole between 2010 and 2016, were identified using the hospital's computerized database...
June 22, 2018: Pediatric Blood & Cancer
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