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Jaime Moreno-García, Minami Ogawa, C M Lucy Joseph, Juan C Mauricio, Juan Moreno, Teresa García-Martínez
Flor yeasts confer a wide range of organoleptic properties to Sherry-type wines during a process called "biological aging" that takes place after alcoholic fermentation. These kinds of yeasts adapt to a biological aging condition by forming a biofilm known as "flor velum" and by changing from fermentative to oxidative metabolism. It has been reported that some functions such as increase of cell surface hydrophobicity or changes to lipid metabolism are enhanced when yeasts switch to biofilm lifestyle...
December 15, 2018: World Journal of Microbiology & Biotechnology
Mauricio Baca, Mark Newberry
BACKGROUND: Cardiac amyloidosis is an underdiagnosed cause of restrictive cardiomyopathy resulting from the infiltration of the myocardium by amyloid proteins. CASE REPORT: We report the case of an 83-year-old woman who presented with increasing dyspnea and lower-extremity swelling. She reported a medical history of unspecified heart failure. Evaluation in the Emergency Department (ED) revealed evidence of heart failure on physical examination, low-voltage electrocardiogram, chest x-ray study with mild pulmonary edema, and laboratory evaluation with elevated brain natriuretic peptide and troponin...
December 12, 2018: Journal of Emergency Medicine
Mauricio Rangel-Gomez, Raul Cruz-Cano, Carly Van Wagoner, Azieb Kidanu, Craig G McDonald, Pamela I Clark
The increased consumption of tobacco products in recent years has been linked, among other factors, to the presence of added flavors. Although flavors are important in explaining consumption, their effects in the brain have until now been unexplored. In the present study, we investigated how electrophysiology can serve to dissociate the effects of nicotine and flavor. Participants attended 4 sessions (2-by-2 factorial design, with flavor and nicotine as within-subject factors), in each session an oddball task was performed before and after smokeless tobacco consumption...
November 14, 2018: Addictive Behaviors
Mauricio Morais, Michelle T Ma
Antibodies and their derivatives radiolabelled with positron- and gamma-emitting radiometals enable sensitive and quantitative molecular Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) imaging of antibody distribution in vivo. Chelators that are covalently attached to antibodies allow radiolabelling with metallic PET and SPECT radioisotopes. Conventional strategies for chelator-protein conjugation generate heterogeneous mixtures of bioconjugates that can exhibit reduced affinity for their receptor targets, and undesirable biodistribution and pharmacokinetics...
December 2018: Drug Discovery Today. Technologies
G F Variane, L M Cunha, P Pinto, P Brandao, R S Mascaretti, Mauricio Magalhães, G M Sant'Anna
OBJECTIVE:  To determine the rate of therapeutic hypothermia (TH) use, current practices, and long-term follow-up. STUDY DESIGN:  Prospective cross-sectional national survey with 19 questions related to the assessment of hypoxic-ischemic encephalopathy (HIE) and TH practices. An online questionnaire was made available to health care professionals working in neonatal care in Brazil. RESULTS:  A total of 1,092 professionals replied, of which 681 (62%) reported using TH in their units...
December 15, 2018: American Journal of Perinatology
Daniella Gregoria Bomfim Prado da Silva, Flávia Jacqueline Almeida, Mariana Volpe Arnoni, Marco Aurélio Palazzi Sáfadi, Marcelo Jenne Mimica, Daniel Jarovsky, Gabriela Pereira de Almeida Rossetti, Mauricio Magalhães, Danielle Bruna Leal de Oliveira, Luciano Matsumiya Thomazelli, Thais Cristina Colmanetti, Edison Luiz Durigon, Eitan Naaman Berezin
OBJECTIVE: Respiratory syncytial virus is a pathogen frequently involved in nosocomial outbreaks. Although several studies have reported nosocomial outbreaks in neonatal intensive care units, molecular epidemiology data are scarce. Here, the authors describe two consecutive respiratory syncytial virus outbreaks caused by genotypes ON-1 and NA-2 in a neonatal intensive care unit in São Paulo, Brazil. METHODS: A prospective search for respiratory syncytial virus was performed after diagnosing the index case and four other symptomatic newborns in the neonatal intensive care unit...
December 12, 2018: Jornal de Pediatria
Thiago M da Silva, Rosemeire L Fiaccone, Fernanda S G Kehdy, Eduardo Tarazona-Santos, Laura C Rodrigues, Gustavo N O Costa, Camila A Figueiredo, Darci N Dos Santos, Caroline A Feitosa, Gisel L Fattore, Leticia M Santos, Neuza M Alcantara-Neves, Álvaro A Cruz, Maurício L Barreto
BACKGROUND: Genetic variants underlying African ancestry have been suggested be implicated in the ethnic-racial inequalities reported for asthma and allergies. OBJECTIVES: To investigate the association between individual African ancestry and asthma symptoms, atopic and non-atopic asthma, and atopy in children. METHODS: A cross-sectional study encompassing 1190 individuals was conducted. African biogeographic ancestry was estimated using 370 539 genome-wide SNPs...
December 11, 2018: Pediatric Pulmonology
Roberto A Abreu-Mendoza, Yaira Chamorro, Mauricio A Garcia-Barrera, Esmeralda Matute
Are mathematical learning difficulties caused by impairment of the abilities that underlie mathematical talent? Or are mathematical difficulties and talent qualitatively different? The main goal of this study was to determine whether mathematical learning difficulties are explained by the same executive functions as mathematical talent. We screened a pool of 2,682 first-year high school students and selected 48 for evaluation, dividing them into three groups: those with mathematical learning difficulties (n = 16), those with typical performance (n = 16), and those with mathematical talent (n = 16)...
2018: PloS One
Jacobo Sellares, Kristen L Veraldi, Katelynn J Thiel, Nayra Cárdenes, Diana Alvarez, Frank Schneider, Joseph M Pilewski, Mauricio Rojas, Carol A Feghali-Bostwick
Idiopathic Pulmonary Fibrosis (IPF) pathogenesis has been postulated to involve a variety of mechanisms associated with the aging process, including loss of protein homeostasis (proteostasis). Heat shock proteins (Hsp) are cellular chaperones that serve a number of vital maintenance and repair functions, including the regulation of proteostasis. Previously published data have implicated Hsp70 in the development of pulmonary fibrosis in animal models. We sought to identify alterations in Hsp70 expression in IPF lung...
December 13, 2018: American Journal of Respiratory Cell and Molecular Biology
Jean-Romain Delaloye, Jozef Murar, Mauricio Gonzalez, Thiago Amaral, Vikram Kakatkar, Bertrand Sonnery-Cottet
Background: Graft rupture rate, return to sport and persistent rotational instability remain a concern postoperatively following anterior cruciate ligament (ACL) reconstruction. The anterolateral ligament (ALL) has recently been shown to act as a lateral knee stabilizer that helps improve rotational stability. To improve functional and clinical outcomes, a combined ACL reconstruction with an associated ALL reconstruction has been proposed. Purpose: The main purpose of this study was to evaluate the clinical outcomes of the combined ACL and ALL reconstruction...
December 2018: Techniques in Orthopaedics: TIO
Mauricio A Martins, Lucas Gonzalez-Nieto, Young C Shin, Aline Domingues, Martin J Gutman, Helen S Maxwell, Diogo M Magnani, Michael J Ricciardi, Núria Pedreño-Lopez, Varian K Bailey, John D Altman, Christopher L Parks, David B Allison, Keisuke Ejima, Eva G Rakasz, Saverio Capuano, Ronald C Desrosiers, Jeffrey D Lifson, David I Watkins
Approximately 50% of rhesus macaques (RMs) expressing the major histocompatibility complex class I (MHC-I) allele Mamu-B*08 spontaneously control chronic phase viremia after infection with the pathogenic simian immunodeficiency virus (SIV)mac239 clone. CD8+ T-cell responses in these animals are focused on immunodominant Mamu-B*08-restricted SIV epitopes in Vif and Nef, and prophylactic vaccination with these epitopes increases the incidence of elite control in SIVmac239-infected Mamu-B*08+ RMs. Here we evaluated if robust vaccine-elicited CD8+ T-cell responses against Vif and Nef can prevent systemic infection in Mamu-B*08+ RMs following mucosal SIV challenges...
December 12, 2018: Journal of Virology
Eduardo García Díaz, Davinia Ramírez Medina, Óscar Mauricio Morera Porras, José Luis Cabrera Mateos
OBJECTIVE: To assess the control of cLDL in diabetic patients, to measure the impact on such control of inertia with lipid-lowering agents and to explore factors that allow for predicting this inertia. METHODS: Study of historical cohorts of diabetic patients. The proportion of patients who achieved the target cLDL levels was estimated. Therapeutic inertia was considered when the dose of the lipid-lowering agents was not adjusted, or a lipid-lowering agent was not changed or added in patients with initial cLDL outside the target...
December 9, 2018: Endocrinología, Diabetes y Nutrición
Elizabeth K Brauer, George V Popescu, Dharmendra K Singh, Mauricio Calviño, Kamala Gupta, Bhaskar Gupta, Suma Chakravarthy, Sorina C Popescu
Plant protein kinases form redundant signaling pathways to perceive microbial pathogens and activate immunity. Bacterial pathogens repress cellular immune responses by secreting effectors, some of which bind and inhibit multiple host kinases. To understand how broadly bacterial effectors may bind protein kinases and the function of these kinase interactors, we first tested kinase-effector (K-E) interactions using the Pseudomonas syringae pv. tomato-tomato pathosystem. We tested interactions between five individual effectors (HopAI1, AvrPto, HopA1, HopM1, and HopAF1) and 279 tomato kinases in tomato cells...
December 12, 2018: PLoS Biology
Fabián A García Daza, Mauricio R Bonilla, Anna Llordes, Javier Carrasco, Elena Akhmatskaya
Garnet-structured Li7 La3 Zr2 O12 is a promising solid electrolyte for next-generation solid-state Li batteries. However, sufficiently fast Li-ion mobility required for battery applications only emerges at high temperatures, upon a phase transition to cubic structure. A well-known strategy to stabilize the cubic phase at room temperature relies on aliovalent substitution; in particular, the substitution of Li+ by Al3+ and Ga3+ ions. Yet, despite having the same formal charge, Ga3+ substitution yields higher conductivities (10-3 S/cm) than Al3+ (10-4 S/cm)...
December 12, 2018: ACS Applied Materials & Interfaces
Alexandre Cavalcante, Públio Cesar C Viana, Giuliano B Guglielmetti, José Pontes Junior, Henrique Nonemacher, Mauricio D Cordeiro, Regis Otaviano F Bezerra, Rafael F Coelho, William Carlos Nahas
No abstract text is available yet for this article.
December 10, 2018: Clinics
Pedro Henrique Magalhães Cardoso, Simone de Carvalho Balian, Herbert Sousa Soares, Karen Roberta Tancredo, Maurício Laterça Martins
The capsalid monogenean Neobenedenia melleni is known as a lethal pathogen for captured marine teleost ornamental fish, if left untreated. This study reports the occurrence of N. melleni parasitizing four species of ornamental reef fish imported into Brazil and maintained in quarantine: Arabian angelfish (Pomacanthus asfur ), yellowbar angelfish (Pomacanthus maculosus), regal angelfish (Pygoplites diacanthus), and bluecheek butterflyfish (Chaetodon semilarvatus). Ten days after the beginning of quarantine, some fish showed behavioral alterations, such as irritability, and corneal opacity, which were rapidly diagnosed to be caused by monogenean parasites by body surface scraping...
December 10, 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
Roberto de Queiroz Padilha, Romeu Gomes, Valéria Vernaschi Lima, Everton Soeiro, José Maurício de Oliveira, Laura Maria Cesar Schiesari, Silvio Fernandes da Silva, Marilda Siriani de Oliveira
This paper aims at proposing validated principles to underpin clinical management as a means to transform healthcare for integrated healthcare systems. The starting point was the conception of clinical management based on structuring elements that do not separate management, care and education. The authors' proposal was submitted to specialists so that a consensus could be reached. At the end of the process, the following principles of clinical management were presented: (1) Focus on health needs and comprehensive care, (2) Quality and safety in healthcare, (3) Articulation and legitimation of different health practices and types of knowledge to face health problems, (4) Power sharing and co-accountability among managers, health professionals and citizens in healthcare production; (5) Education of people and organizations; (6) Focus on outcomes that add value to health and life; (7) Transparency and accountability regarding collective interests...
December 2018: Ciência & Saúde Coletiva
Antonio Matos Rocha, Maurício Mendes de Albuquerque, Eduardo Miguel Schmidt, Cristiano Denoni Freitas, João Paulo Farias, Fernanda Bedin
BACKGROUND: Deep infiltrating colorectal endometriosis may severely affect the quality of life and fertility of patients. Although segmental resection is a therapeutic option that provides positive outcomes in the management of symptoms, its functional effects are still unproven. AIM: Assess the late impact of the laparoscopic approach in treating deep infiltrating endometriosis with segmental colorectal resection. METHODS: Prospective case series of 46 patients submitted to laparoscopic treatment of deep infiltrating endometriosis with segmental colorectal resection between 2013 and 2016...
December 6, 2018: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Christiano Marlo Paggi Claus, Flavio Malcher, Leandro Totti Cavazzola, Marcelo Furtado, Alexander Morrell, Mauricio Azevedo, Luciana Guimarães Meirelles, Heitor Santos, Rodrigo Garcia
BACKGROUND: Diastasis of the rectus abdominis muscles (DMRA) is frequent and may be associated with abdominal wall hernias. For patients with redudant skin, dermolipectomy and plication of the diastasis is the most commonly used procedure. However, there is a significant group of patients who do not require skin resection or do not want large incisions. AIM: To describe a "new" technique (subcutaneous onlay laparoscopic approach - SCOLA) for the correction of ventral hernias combined with the DMRA plication and to report the initial results of a case series...
December 6, 2018: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Louise Correia Lima, Gerson de Almeida Queiroz, Ryan Dos Santos Costa, Neuza Maria Alcantara-Neves, Cíntia Rodrigues Marques, Gustavo Nunes de Oliveira Costa, Mauricio Lima Barreto, Camila Alexandrina Viana Figueiredo, Valdirene Leão Carneiro
Asthma and allergy affect hundreds of millions of people from childhood to old age. In most of them, the inflammatory process of respiratory allergies involves the participation of type 2 cytokines, derived from T helper-2 (Th2)-cell, and Group 2 Innate Lymphoid (ILC2) Cells. An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells are derived from common lymphoid progenitors and their growing depends on the transcription factor RORA...
January 2019: Cytokine
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