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Esteban W Rivarola, Mauricio I Scanavacca
No abstract text is available yet for this article.
July 2018: Arquivos Brasileiros de Cardiologia
Tan Chen Wu, Denise T Hachul, Francisco Carlos da Costa Darrieux, Maurício I Scanavacca
BACKGROUND: Carotid sinus hypersensitivity (CSH) is a frequent finding in the evaluation of syncope. However, its significance in the clinical setting is still dubious. A new criterion was proposed by Solari et al. with a symptomatic systolic blood pressure (SBP) cut-off value of ≤ 85 mmHg to refine the vasodepressor (VD) response diagnosis. OBJECTIVE: To determine and compare the response to carotid sinus massage (CSM) in patients with and without syncope according to standard and proposed criteria...
July 2018: Arquivos Brasileiros de Cardiologia
Sarah C W S E Franco de Oliveira, Alexandre D Zucoloto, Carolina D R de Oliveira, Edna M M Hernandez, Ligia V G Fruchtengarten, Tiago F de Oliveira, Mauricio Yonamine
This work describes a simple approach to overcome challenges in emergency toxicological analysis, using liquid-liquid extraction and high-performance liquid chromatography coupled with a diode-array detector (HPLC-DAD). A rapid procedure has been developed, for the extraction and detection of 19 analytes from the following drug classes: analgesics, benzodiazepines, antidepressants, anticonvulsants and drugs of abuse. These substances are relevant in the context of emergency toxicology in Brazil. The method has been validated according to international guidelines by establishing parameters such as lower limit of quantification, sensitivity, linearity, accuracy and precision...
August 14, 2018: Biomedical Chromatography: BMC
Montserrat Doria, Jordi Viadé, Elisabet Palomera, Ricard Pérez, Melcior Lladó, Elisabet Costa, Teresa Huguet, Jordi Lluís Reverter, Mateu Serra-Prat, Josep Franch-Nadal, Dídac Mauricio
OBJECTIVES: To assess the clinical characteristics of patients with Charcot neuroarthropathy (CN) in Spain and to identify predictors for CN-related complications. PATIENTS AND METHODS: A retrospective study was conducted at five tertiary hospitals with diabetic foot care units in Spain. Data were collected from 83 patients, including demographic profiles, foot factors, diabetes characteristics, and presence of microvascular and macrovascular comorbidity, and a podiatric examination was also performed...
August 11, 2018: Endocrinología, Diabetes y Nutrición
Diana Costa, Camila Cardoso Diogo, Luís Maltez da Costa, José Eduardo Pereira, Vítor Filipe, Pedro Alexandre Couto, Stefano Geuna, Paulo A Armada-Da-Silva, Ana Colette Maurício, Artur S P Varejão
Functional recovery following general nerve reconstruction is often associated with poor results. Comparing to rat and mice experimental studies, there are much fewer investigations on nerve regeneration and repair in the sheep, and there are no studies on this subject using gait analysis in the sheep model as an assessment tool. Additionally, this is the first study evaluating obstacle negotiation and the compensatory strategies that take place at each joint in response to the obstacle during locomotion in the sheep model...
August 14, 2018: Neurological Research
Andrea L Axtell, Amy G Fiedler, David C Chang, Heidi Yeh, Gregory D Lewis, Mauricio A Villavicencio, David A D'Alessandro
Hearts from older donors are increasingly utilized for transplantation due to unmet demand. Conflicting evidence exists regarding the prognosis of recipients of advanced age donor hearts, especially in young recipients. A retrospective analysis was performed on 11,433 patients aged 18-45 who received a cardiac transplant from 2000-2017. Overall 10,279 patients received hearts from donors less than 45 and 1,145 from donors greater than 45. Recipients of older donors were older (37 vs 34 years, p<0.01) and had higher rates of inotropic dependence (48% vs 42%, p<0...
August 14, 2018: American Journal of Transplantation
Ediléia Bagatin, Heitor de Sá Gonçalves, Maurício Sato, Luiz Maurício Costa Almeida, Helio Amante Miot
BACKGROUND: Adapalene has been previously evaluated as a treatment for actinic keratosis (AK) and solar lentigines and shown to improve signs of photoaging. OBJECTIVES: To evaluate whether adapalene 0.3% gel is non-inferior to tretinoin 0.05% cream as treatment for photoaged skin. MATERIALS & METHODS: An investigator-blinded, parallel-group comparison study was conducted in Brazil. Subjects were randomised in a 1:1 ratio to receive, once daily, adapalene 0...
June 1, 2018: European Journal of Dermatology: EJD
Harvy Mauricio Velasco Parra, Silvia Juliana Maradei Anaya, Johanna Carolina Acosta Guio, Clara Eugenia Arteaga Diaz, Juan Carlos Prieto Rivera
Case Presentation: Pelizaeus Merzbacher Disease (PMD) is an X-linked developmental defect of myelination that causes childhood chronic spastic encephalopathy. Its genetic etiology can be either a duplication (or other gene dosage alterations) or a punctual mutation at the PLP1 locus. Clinically, it presents with developmental delay, nystagmus and, spasticity, supported by neuroimaging in which the defect of myelination is evident. We present a series of seven Colombian patients diagnosed with this leucodystrophy, describing their genotypic and phenotypic characteristics and heterogeneity...
June 30, 2018: Colombia Médica: CM
Gloria Lucía Lema-Zuluaga, Mauricio Fernandez-Laverde, Ana Marverin Correa-Varela, John J Zuleta-Tobón
Objective: To compare two endotracheal suctioning protocols according to morbidity, days of mechanical ventilation, length of stay in the Pediatric Intensive Care Unit (PICU), incidence of Ventilator-Associated Pneumonia (VAP) and mortality. Methods: A Pragmatic randomized controlled trial performed at University Hospital Pablo Tobón Uribe, Medellin-Colombia. Forty-five children underwent an as-needed endotracheal suctioning protocol and forty five underwent a routine endotracheal suctioning protocol...
June 30, 2018: Colombia Médica: CM
Carlos A Loncoman, Carol A Hartley, Mauricio J C Coppo, Glenn F Browning, José A Quinteros, Andrés Diaz-Méndez, Dulari Thilakarathne, Omid Fakhri, Paola K Vaz, Joanne M Devlin
Recombination is closely linked with virus replication and is an important mechanism that contributes to genome diversification and evolution in alphaherpesviruses. Infectious laryngotracheitis (ILTV; Gallid alphaherpesvirus 1) is an alphaherpesvirus that causes respiratory disease in poultry. In the past, natural (field) recombination events between different strains of ILTV generated virulent recombinant viruses that have caused severe disease and economic loss in poultry industries. In this study, chickens were vaccinated with attenuated ILTV vaccines to examine the effect of vaccination on viral recombination and diversity following subsequent co-inoculation with two field strains of ILTV...
August 10, 2018: Vaccine
Tiago José Marques Fraga, Marilda Nascimento Carvalho, Daysianne Mikaella Dos Santos Marques Fraga, Maria do Carmo Lourenço da Silva, Joelma Morais Ferreira, Maurício Alves da Motta Sobrinho
The residue generated in the aluminium cold lamination (TTR) was submitted to a direct burning and then it was calcined at 500°C. BET, FTIR, SEM with EDX and TGA techniques were performed to characterize the adsorbent before and after the adsorption. BET analysis showed that TTR specific surface area was 55.37 m2 ·g-1 and there were no significant changes after the adsorptive process. Afterwards the TTR was applied as adsorbent of the reactive Drimaren Blue (DB), Drimaren Red (DR) and Drimaren Gold (DG). Its employment consists in a sustainable alternative for the treatment of textile wastewater, once the TTR was used as low cost adsorbent of textile dyes...
August 13, 2018: Environmental Technology
Rômulo Ribeiro do Vale, Nathalia da Silva Conci, Alexandre Pinheiro Santana, Mauricio Baptista Pereira, Natália Yume Hissayasu Menezes, Vilma Takayasu, Lorena Silva Laborda, Aloísio Souza Felipe da Silva
Celiac disease (CD)-also known as gluten-sensitive enteropathy-is a chronic, genetically predisposing and autoimmune entity with a wide range of clinical manifestations triggered by gluten ingestion, which affects 1% of the general population. Currently, up to 60% of the diagnosis of CD is in adults due to the atypical course of the disease. The severe acute onset of CD-also called celiac crisis-is very uncommon and is still not well documented in adults. We report the case of a 58-year-old man who presented a 45-day history of subtle-onset diarrhea followed by malabsorption syndrome with progressive weight loss, anasarca, and electrolyte disturbances...
July 2018: Autopsy & Case Reports
Tomás Merino, Teresa Ip, Francisco Domínguez, Francisco Acevedo, Lidia Medina, Alejandra Villaroel, Mauricio Camus, Eugenio Vinés, César Sánchez
Background: Although fairly uncommon, loco-regional recurrence in breast cancer (BC) has major consequences for the patient. Several predictors for locoregional have been previously reported from large randomized clinical trials mainly from Europe & North America; data from other geographical areas are somewhat scarce. Here we performed a retrospective review of medical records in a single academic center in Chile, searching for predictors of breast tumor recurrence. Results: Median patient follow up was 61 months, 5 year overall survival (OS) rate was 94...
July 13, 2018: Oncotarget
José Miguel Rodríguez-Santos, Javier García-Orza, Marina Calleja, Jesús Damas, Mauricio Iza
It is commonly found that deaf and hard of hearing (DHH) students experience delayed mathematical achievement. The present study used two nonsymbolic comparison tasks to explore the basic numerical skills of DHH students. Nine prelocutive DHH students with cochlear implants and nine hearing students, matched on nonverbal IQ, visual short-term memory, and verbal comprehension, were recruited. The participants performed two different collection comparison tasks with different ratios and under different perceptual conditions...
2018: American Annals of the Deaf
Mauricio Acelas, Vladimir V Kouznetsov, Arnold R Romero Bohórquez
A novel and highly efficient synthetic approach for the expedite construction of new octahydroacridine-isoxazole- and octahydroacridine-1,2,3-triazole-based molecular hybrids is first reported. Rapid access to the octahydroacridine core was achieved in a highly diastereoselective fashion via cationic Povarov reaction of N-propargyl anilines and citronella essential oil (Cymbopogon nardus). The subsequent 1,3-dipolar and Cu (I) catalyzed alkyne-azide cycloaddition reaction of the terminal alkyne fragment with the corresponding oxime or azide affords the desired 3,5-isoxazoles and 1,2,3-triazoles, respectively, as interesting molecular hybrid models for pharmacological studies...
August 11, 2018: Molecular Diversity
Alysson V F Sako, Daniel A Spudeit, Maurício Dupim, Waldemar P O Filho, Tatiana D Saint'Pierre, Marcone A L de Oliveira, Gustavo A Micke
A novel method for the sequential determination of sodium, potassium, calcium, and magnesium and free and total glycerol in biodiesel by capillary zone electrophoresis is proposed herein. The inorganic cations were separated along an effective length of 43.5 cm. The samples to quantify the free and total glycerol were injected into the opposite capillary end, close to the detection window, with an effective length of 8.5 cm. It was possible to achieve the separation of six analytes within 3 min. The quantification limits for the cations and glycerol ranged from 0...
July 29, 2018: Journal of Chromatography. A
D Vázquez-Justes, J Sanahuja, J Diez, E Rubinat, R Begué, C Salas, C Vicandi, M I Gil, F Purroy, D Mauricio
OBJECTIVE: To study the frequency and management of incidental findings in nonenhanced brain MRI of a middle-aged population of type 2 diabetic patients. METHODS: We retrospectively analyzed the results of 289 brain MRI obtained from subjects between 40-75 years recruited from a previous study. Incidental findings were classified into three categories: 1) Vascular findings; 2) neoplastic findings; and 3) others. On the other side, we made a classification of referral findings...
August 8, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
Eric Wakshull, Robert Avery, Mauricio Maia
No abstract text is available yet for this article.
August 1, 2018: Investigative Ophthalmology & Visual Science
Hari-Mandir K Khalsa, Ross J Baldessarini, Mauricio Tohen, Paola Salvatore
BACKGROUND: Aggression by patients with bipolar I disorder (BD-I) is not uncommon. Identifying potential risk factors early in the illness-course should inform clinical management and reduce risk. METHODS: In a study sample of 216 initially hospitalized, first-psychotic episode subjects diagnosed with DSM-IV-TR BD-I, we identified recent (within 1 month before hospitalization) aggression by ratings on the Brief Psychiatric Rating Scale-Expanded and review of detailed clinical research records...
August 11, 2018: International Journal of Bipolar Disorders
Renata Rocha de Oliveira, Raphael Morales-Neto, Silvana Aparecida Rocco, Maurício Luis Sforça, Carla Cristina Polo, Celisa Caldana Costa Tonoli, Gustavo Fernando Mercaldi, Artur Torres Cordeiro, Mário Tyago Murakami, Kleber Gomes Franchini
Adenosine Kinase (ADK) regulates the cellular levels of adenosine (ADO) by fine-tuning its metabolic clearance. The transfer of γ-phosphate from ATP to ADO by ADK involves regulation by the substrates and products, as well as by Mg2+ and inorganic phosphate. Here we present new crystal structures of mouse ADK (mADK) binary (mADK:ADO; 1.2 Å) and ternary (mADK:ADO:ADP; 1.8 Å) complexes. In accordance with the structural demonstration of ADO occupancy of the ATP binding site, kinetic studies confirmed a competitive model of auto-inhibition of ADK by ADO...
August 10, 2018: Scientific Reports
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