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Neurological Lyme

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https://www.readbyqxmd.com/read/29744083/autonomous-dysfunction-in-lyme-neuroborreliosis-a-case-report
#1
Bent-Are Hansen, Torgeir Finjord, Øyvind Bruserud
The diagnosis of Lyme neuroborreliosis should be considered whenever a patient presents with neurological symptoms and comes from an endemic area. However, atypical clinical presentation occurs including gastrointestinal manifestations because of autonomous dysfunction.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29705691/cxcl13-concentrations-in-cerebrospinal-fluid-of-patients-with-lyme-neuroborreliosis-and-other-neurological-disorders-determined-by-luminex-and-elisa
#2
Mateusz Markowicz, Anna-Margarita Schötta, Michael Kundi, Petra Bogovič, Katarina Ogrinc, Franc Strle, Gerold Stanek
The aims of the study were to determine and compare the concentration of CXCL13 in cerebrospinal fluid (CSF) of patients with Lyme neuroborreliosis (LNB) and various other neurological disorders applying a Luminex based assay and ELISA, and to find factors associated with CXCL13 concentration. CSF samples obtained from four clinically well-defined groups of patients (proven LNB, suspected LNB, tick-borne encephalitis (TBE), and aseptic meningitis/meningoencephalitis other than TBE) - 25 samples per group - were analyzed...
April 20, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29674128/diagnostic-value-of-cerebrospinal-fluid-cxcl13-for-acute-lyme-neuroborreliosis-a-systemic-review-and-meta-analysis
#3
REVIEW
Tobias Armin Rupprecht, Kirsi Marjaana Manz, Volker Fingerle, Christian Lechner, Matthias Klein, Markus Pfirrmann, Uwe Koedel
OBJECTIVES: The utility of cerebrospinal fluid (CSF) CXCL13 for diagnosis of acute Lyme neuroborreliosis (LNB) has been debated and the test is not yet routinely performed. This study's aim was to evaluate its overall diagnostic accuracy through meta-analysis. METHODS: Electronic searches in PubMed MEDLINE and Web of Science were performed to identify relevant articles published before January 2018. A summary receiver operating characteristic curve and an optimal cut-off were estimated modeling multiple cut-offs...
April 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29613895/infectious-myelopathies
#4
Marie F Grill
PURPOSE OF REVIEW: This article reviews bacterial, viral, fungal, and parasitic pathogens associated with myelopathy. Infectious myelopathies may be due to direct infection or parainfectious autoimmune-mediated mechanisms; this article focuses primarily on the former. RECENT FINDINGS: Some microorganisms exhibit neurotropism for the spinal cord (eg, enteroviruses such as poliovirus and flaviviruses such as West Nile virus), while others are more protean in neurologic manifestations (eg, herpesviruses such as varicella-zoster virus), and others are only rarely reported to cause myelopathy (eg, certain fungal and parasitic infections)...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29610173/sternoclavicular-arthritis-as-a-clinical-presentation-for-lyme-disease
#5
Sriram Ramgopal, Margalit Rosenkranz, Andrew J Nowalk, Noel S Zuckerbraun
Lyme disease is caused by Borrelia burgdorferi and can lead to dermatologic, neurologic, cardiac, and musculoskeletal manifestations. The arthritis of Lyme disease is typically monoarticular, with the knee being most commonly involved. Lyme arthritis of small joints has not previously been well described. We report 3 children who presented with sternoclavicular joint swelling and who were found to have Lyme disease based on enzyme-linked immunosorbent assay and Western blot. This description of sternoclavicular Lyme arthritis highlights the importance of considering Lyme disease in the differential and diagnostic workup of new onset, small joint arthritis in patients presenting from or with travel to Lyme endemic regions...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29602888/pseudotumor-cerebri-as-the-presentation-of-lyme-disease-in-a-non-endemic-area
#6
Marta Ezequiel, Ana Teresa Teixeira, Maria João Brito, Catarina Luís
Intracranial hypertension is a rare entity in prepubertal children, and its differential diagnosis includes a number of systemic diseases, drugs, vitamin deficiencies and excesses, and hereditary conditions. Infectious aetiology is rare. The case of a 9-year-old boy with intracranial hypertension secondary to acute neuroborreliosis is described. He presented with daily pulsatile frontotemporal headache, pallor, photophobia and phonophobia. His neurological examination revealed papilledema with no nuchal rigidity...
March 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29543607/ce-lyme-disease-diagnosis-treatment-and-prevention
#7
Susan Kane Patton, Bailey Phillips
: Lyme disease is recognized as the most common vector-borne disease in the United States. Surveillance data indicate both increasing numbers of Lyme disease cases and geographic expansion of areas where the causative spirochete, Borrelia burgdorferi, can be found. With prompt diagnosis and appropriate treatment in the acute stage, most patients will recover fully. Without treatment, however, the infecting pathogen remains within the body, often producing long-term complications, including musculoskeletal, neurologic, and cardiovascular effects...
April 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29477274/is-the-risk-of-early-neurologic-lyme-borreliosis-reduced-by-preferentially-treating-patients-with-erythema-migrans-with-doxycycline
#8
Franc Strle, Daša Stupica, Petra Bogovič, Paul Visintainer, Gary P Wormser
Doxycycline is highly effective treatment for early neurologic Lyme borreliosis (NLB). Nineteen studies were reviewed to determine if treatment of patients with erythema migrans with other oral antibiotics would increase the risk for developing NLB. In the eight studies that directly compared doxycycline to another antibiotic, the pooled difference indicated a 0.2% greater risk of developing NLB in doxycycline-treated patients (95% CI: -1.0%, +1.4%; P = 0.77), with an estimated heterogeneity of 0.0%, P = 0...
February 2, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29460492/cerebrospinal-fluid-lyme-multiplex-assay-results-are-not-diagnostic-in-horses-with-neuroborreliosis
#9
Amy L Johnson, Laura K Johnstone, Darko Stefanovski
BACKGROUND: The accuracy of the Lyme multiplex assay for the diagnosis of neuroborreliosis in horses is unknown. HYPOTHESIS/OBJECTIVES: To describe Lyme multiplex results in horses with a postmortem diagnosis of neuroborreliosis. The hypothesis was that paired serum and cerebrospinal fluid (CSF) results and a CSF : serum ratio would allow differentiation of horses with neuroborreliosis from those with other neurologic diseases. ANIMALS: Ninety horses that had neurologic examinations, serum and CSF Lyme multiplex analyses, and postmortem examination of the nervous system performed...
March 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29416466/exacerbation-of-chronic-pain-after-dental-extractions-in-a-patient-with-post-treatment-lyme-disease-syndrome
#10
Stephanie Lim, Sakura Kinjo
A subset of patients who had Lyme disease experience postinfectious signs or symptoms called post-treatment Lyme disease syndrome (PTLDS). PTLDS is a chronic condition including pain in joints and muscles, neurological symptoms including demyelinating diseases, peripheral neuropathy, headaches, sleep disturbances, fatigue, and cardiac conditions. We report a case of difficult acute pain management in a patient with PTLDS who underwent dental extractions and required admission to an intensive care unit for pain control...
January 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29402399/tick-borne-illness-lyme-disease
#11
REVIEW
Larry M Bush, Maria T Vazquez-Pertejo
Lyme disease is the most commonly reported tick-borneillness in the United States. Thecausative spirochete, Borrelia burgdorferi is transmitted by 4 species of Ixodes tick species. Over 90% of US cases occur in northeasternstates from Maine to Virginia, and in Wisconsin, Minnesota, and Michigan. Infection also takes place in northern California and Oregon. Lyme borreliosis is also diagnosed in parts of Europe, China, and Japan. The white-footed mouse is the primary animal reservoir for B. burgdorferi in the U...
February 2, 2018: Disease-a-month: DM
https://www.readbyqxmd.com/read/29386499/-a-case-of-lyme-neuroborreliosis-without-erythema-migrans
#12
Katsuki Eguchi, Kazuhumi Tsuzaka, Ichiro Yabe, Hidenao Sasaki
A 56-year-old man was sustained ticks at the left axilla and flank. He did not have a rash. About 3 months after the tick bites, he developed back pain, right leg weakness, right abducens nerve palsy, and left facial palsy. Western blot analysis for serum IgM and IgG antibodies against Borrelia were positive. We diagnosed Lyme borreliosis. The patient was treated with antibiotics and steroids, and the symptoms improved. Our findings demonstrate that, even if erythema migrans is not obvious, neuroborreliosis should be considered when neurological signs, such as multiple cranial nerve palsies, are present...
February 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29359181/development-and-validation-of-a-serologic-test-panel-for-detection-of-powassan-virus-infection-in-u-s-patients-residing-in-regions-where-lyme-disease-is-endemic
#13
Angela M Thomm, Anna M Schotthoefer, Alan P Dupuis, Laura D Kramer, Holly M Frost, Thomas R Fritsche, Yvette A Harrington, Konstance K Knox, Sue C Kehl
Powassan virus (POWV) is an emerging tick-borne arbovirus presenting a public health threat in North America. POWV lineage II, also known as deer tick virus, is the strain of the virus most frequently found in Ixodes scapularis ticks and is implicated in most cases of POWV encephalitis in the United States. Currently, no commercial tests are available to detect POWV exposure in tick-borne disease (TBD) patients. We describe here the development and analytical validation of a serologic test panel to detect POWV infections...
January 2018: MSphere
https://www.readbyqxmd.com/read/29277293/challenging-diagnosis-and-inpatient-rehabilitation-of-acute-bilateral-neuralgic-amyotrophy-possibly-attributed-to-lyme-disease-a-case-report
#14
Shangming Zhang, Lucy Q Zhang, Megan Wright, David R Gater
Neuralgic amyotrophy (NA) is a neurologic syndrome of unknown etiology primarily affecting the brachial plexus. We are reporting an unusual case of acute bilateral NA that was possibly secondary to Lyme disease. The patient demonstrated significant functional gains and was discharged home after 2 weeks of inpatient rehabilitation, supporting the role of inpatient rehabilitation in acute NA. In this report, we discuss the diagnosis, electrodiagnostic progression, pain management, goals for inpatient rehabilitation, and overall prognosis of NA...
December 20, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29231910/-clinical-pictures-of-borreliosis
#15
EDITORIAL
Tadeusz Płusa
Lyme disease occurs in a variety of clinical manifestations, ranging from skin lesions, through musculoskeletal, neurological, and cardiac syndrome, to severe irreversible lesions. Borrelia burgdorferi's organotropy has an impact on the development of the disease. In initial management, it is important to implement effective treatment to prevent further progression of infection. Dominant skin lesions should be differentiated in detail. In the form of disseminated disease complex of clinical syndromes is observed but it requires of confirmation in immunoassays...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29208342/pediatric-stroke-related-to-lyme-neuroborreliosis-data-from-the-swiss-neuropaediatric-stroke-registry-and-literature-review
#16
O Monteventi, M Steinlin, M Regényi, E Roulet-Perez, P Weber, J Fluss
BACKGROUND: Cerebrovascular complications of Lyme neuroborreliosis (LNB) are poorly documented in the paediatric population. METHODS: We performed a retrospective analysis from prospectively registered cases of acute ischemic stroke (AIS) from the Swiss NeuroPaediatric Stroke Registry (SNPSR) from 2000 to 2015. Only cases with serologically confirmed LNB were included. In addition, a literature review on paediatric stroke cases secondary to Lyme neuroborreliosis in the same time frame was performed...
January 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29048514/characteristics-and-clinical-outcome-of-lyme-neuroborreliosis-in-a-high-endemic-area-1995-2014-a-retrospective-cohort-study-in-denmark
#17
Fredrikke Christie Knudtzen, Nanna Skaarup Andersen, Thøger Gorm Jensen, Sigurdur Skarphédinsson
Background: Despite a well-described symptomatology, treatment delay and sequelae are common in patients with Lyme neuroborreliosis (LNB). The aim of this study was to contribute to the knowledge about the symptomatology and epidemiology of LNB. Methods: We conducted a retrospective study of all LNB cases verified by a positive Borrelia intrathecal antibody index test performed at the Department of Microbiology, Odense University Hospital, Denmark, from 1995 through 2014...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29026617/cerebral-vasculitis-and-intracranial-multiple-aneurysms-in-a-child-with-lyme-neuroborreliosis
#18
Elisa Kortela, Jukka Hytönen, Jussi Numminen, Margit Overmyer, Harri Saxen, Jarmo Oksi
Introduction. Lyme borreliosis is a multisystem tick-borne disease caused by Borrelia burgdo rferi . Neurological manifestations are reported in up to 15 % of adult patients with Lyme disease, while the frequency among children is higher. The most common manifestations are painful radiculopathy, facial nerve paresis and lymphocytic meningitis. Epileptic seizures and cerebral vasculitis with stroke or aneurysms are very rare complications. Case presentation. We describe a paediatric patient with sensorineural auditory dysfunction, headache, fatigue and epileptic seizures as sequelae of meningoencephalitis/Lyme neuroborreliosis (LNB) caused by B...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/28988602/a-new-hot-spot-for-tick-borne-encephalitis-tbe-a-marked-increase-of-tbe-cases-in-france-in-2016
#19
Aurélie Velay, Morgane Solis, Wallys Kack-Kack, Pierre Gantner, Marianne Maquart, Martin Martinot, Olivier Augereau, Dominique De Briel, Pierre Kieffer, Caroline Lohmann, Jean Dominique Poveda, Emmanuelle Cart-Tanneur, Xavier Argemi, Isabelle Leparc-Goffart, Sylvie de Martino, Benoit Jaulhac, Sophie Raguet, Marie-Josée Wendling, Yves Hansmann, Samira Fafi-Kremer
OBJECTIVES: Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis. In 2016, in Northeastern France, we faced a TBEV infection increase, leading to a warning from the Regional Health Agency. Here, we report the confirmed TBE cases diagnosed between January 2013 and December 2016, with particular emphasis on the year 2016. METHODS: A total of 1643 blood and cerebrospinal fluid (CSF) samples from everywhere in France, corresponding to 1460 patients, were prospectively tested for anti-TBEV-specific IgM and IgG antibodies by ELISA...
September 28, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28972436/chemokine-cxc-ligand-13-in-cerebrospinal-fluid-can-be-used-as-an-early-diagnostic-biomarker-for-lyme-neuroborreliosis-a-meta-analysis
#20
Jiaru Yang, Xinlin Han, Aihua Liu, Fukai Bao, Yun Peng, Lüyan Tao, Mingbiao Ma, Ruolan Bai, Xiting Dai
Lyme neuroborreliosis (LNB), which is the most common neurological manifestation of Lyme disease (LD), seriously impairs both the central and peripheral nervous systems. Current LNB diagnostic methods and criteria are not very effective. Recently, several studies have indicated that a high concentration of the chemokine CXC ligand 13 (CXCL13) in cerebrospinal fluid (CSF) could be used as a new biomarker for the diagnosis of LNB. Thus, we carried out a meta-analysis to systematically analyze the data from these studies to evaluate the value of CXCL13 as an LNB biomarker...
October 2017: Journal of Interferon & Cytokine Research
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