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Neurological Lyme

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https://www.readbyqxmd.com/read/28714333/-borrelia-miyamotoi-a-recently-identified-human-pathogenic-tick-borne-relapsing-fever-spirochete
#1
Sándor Szekeres, András Lakos, Gábor Földvári
Borrelia miyamotoi is a recently described relapsing fever spirochete transmitted by ticks of the Ixodes ricinus complex. This pathogen is different from Borrelia burgdorferi sensu lato (the Lyme borreliosis spirochetes) in its epidemiology, ecology and also genetics. Over 50 patients have been described worldwide with Borrelia miyamotoi disease, and three immunocompromised patients were reported with neurological symptoms. Our knowledge about Borrelia miyamotoi infection in ticks and its distribution in different habitats and also the mechanism of the infection is limited...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28703098/surveillance-perspective-on-lyme-borreliosis-across-the-european-union-and-european-economic-area
#2
Cees C van den Wijngaard, Agnetha Hofhuis, Mariana Simões, Ente Rood, Wilfrid van Pelt, Herve Zeller, Wim Van Bortel
Lyme borreliosis (LB) is the most prevalent tick-borne disease in Europe. Erythema migrans (EM), an early, localised skin rash, is its most common presentation. Dissemination of the bacteria can lead to more severe manifestations including skin, neurological, cardiac, musculoskeletal and ocular manifestations. Comparison of LB incidence rates in the European Union (EU)/European Economic Area (EEA) and Balkan countries are difficult in the absence of standardised surveillance and reporting procedures. We explored six surveillance scenarios for LB surveillance in the EU/EEA, based on the following key indicators: (i) erythema migrans, (ii) neuroborreliosis, (iii) all human LB manifestations, (iv) seroprevalence, (v) tick bites, and (vi) infected ticks and reservoir hosts...
July 6, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28681315/management-of-lyme-disease-in-european-children-a-review-for-practical-purpose
#3
REVIEW
Matteo D'Alessandro, Anna Loy, Elio Castagnola
PURPOSE OF REVIEW: Lyme disease is a tick-borne zoonosis transmitted through a bite of a tick carrying a spirochete belonging to Borrelia species. In the last 20 years, the reported incidence of Lyme disease is increased by three times in Europe. Clinically, the illness develops through a primary stage with a typical skin rash (erythema marginatum), then a secondary stage with possible neurologic or cardiac involvement. The last stage (chronic Lyme disease) is mainly represented by arthritis or late neurological complications but nowadays is rarely seen due to precocious antibiotic use...
July 5, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28616477/is-there-a-lyme-like-disease-in-australia-summary-of-the-findings-to-date
#4
REVIEW
Melissa Judith Chalada, John Stenos, Richard Stewart Bradbury
Lyme Borreliosis is a common tick-borne disease of the northern hemisphere caused by the spirochaetes of the Borrelia burgdorferi sensu lato (B. burgdorferi s. l.) complex. It results in multi-organ disease with arthritic, cardiac, neurological and dermatological manifestations. In the last twenty-five years there have been over 500 reports of an Australian Lyme-like syndrome in the scientific literature. However, the diagnoses of Lyme Borreliosis made in these cases have been primarily by clinical presentation and laboratory results of tentative reliability and the true cause of these illnesses remains unknown...
December 2016: One Health
https://www.readbyqxmd.com/read/28550059/europe-wide-meta-analysis-of-borrelia-burgdorferi-sensu-lato-prevalence-in-questing-ixodes-ricinus-ticks
#5
Martin Strnad, Václav Hönig, Daniel Růžek, Libor Grubhoffer, Ryan O M Rego
Lyme borreliosis is the most common zoonotic disease transmitted by ticks in Europe and North America. Despite having multiple tick vectors, the causative agent Borrelia burgdorferi sensu lato, is vectored mainly by Ixodes ricinus in Europe. In the present study, we aimed to review and summarize the existing data published from 2010 to 2016 concerning the prevalence of B. burgdorferi s.l. spirochetes in questing I. ricinus The primary focus was to evaluate the infection rate of these bacteria in ticks, accounting for tick stage, adult tick gender, region and detection method, as well as to investigate any changes in prevalence over time...
May 26, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28512589/a-case-of-early-disseminated-neurological-lyme-disease-followed-by-atypical-cutaneous-manifestations
#6
Vamsi Kantamaneni, Vikas Sunder, Mohammad Bilal, Scott Vargo
Lyme disease (LD) is a tick-borne illness caused by Borrelia burgdorferi sensu stricto. An 80-year-old female from Pennsylvania, USA, presented to an outside hospital with fever, confusion, lower extremity weakness, and stool incontinence. CT head and MRI spine were unremarkable. An infectious work-up including lumbar puncture was negative. She was transferred to our tertiary care hospital. Patient was noted to have mild unilateral right-sided facial droop and a diffuse macular rash throughout the body. She denied any outdoor activities, tick bites, or previous rash...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28457619/borrelia-burgdorferi-specific-iga-in-lyme-disease
#7
Christina D'Arco, Raymond J Dattwyler, Paul M Arnaboldi
The laboratory diagnosis of Lyme disease is currently dependent on the detection of IgM and IgG antibodies against Borrelia burgdorferi, the causative agent of the disease. The significance of serum IgA against B. burgdorferi remains unclear. The production of intrathecal IgA has been noted in patients with the late Lyme disease manifestation, neuroborreliosis, but production of antigen-specific IgA during early disease has not been evaluated. In the current study, we assessed serum IgA binding to the B. burgdorferi peptide antigens, C6, the target of the FDA-cleared C6 EIA, and FlaB(211-223)-modVlsE(275-291), a peptide containing a Borrelia flagellin epitope linked to a modified VlsE sequence, in patients with early and late Lyme disease...
May 2017: EBioMedicine
https://www.readbyqxmd.com/read/28416425/-bilateral-facial-nerve-palsy-associated-with-epstein-barr-virus-infection-in-a-3-year-old-boy
#8
M Grassin, A Rolland, N Leboucq, A Roubertie, F Rivier, P Meyer
Bilateral facial nerve palsy is a rare and sometimes difficult diagnosis. We describe a case of bilateral simultaneous facial nerve palsy associated with Epstein-Barr virus (EBV) infection in a 3-year-old boy. Several symptoms led to the diagnosis of EBV infection: the clinical situation (fever, stomachache, and throat infection), white blood cell count (5300/mm(3) with 70% lymphocyte count), seroconversion with EBV-specific antibodies, lymphocytic meningitis, and a positive blood EBV polymerase chain reaction (9...
April 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28414663/not-another-acs-rule-out
#9
S Preston, R Nelson, M Watts, D Smith, T Dewenter, D Spruill
CASE: A 50 year old African-American woman with diabetes, hypertension, and hyperlipidemia presented with progressively worsening retro-sternal chest pain, exacerbated by activity and relieved by rest. She also endorsed a thirty-pound unintentional weight loss, and dysphagia. She was dysarthric with left-sided Bell's Palsy and a palpable left axillary lymph node. She had been evaluated at several hospitals in the previous months for similar typical chest pain. Her troponin values were normal, and an EKG showed T-wave inversions in leads I and aVL...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28369369/was-it-authentic-lyme-disease-or-some-other-disorder
#10
LETTER
Charles S Pavia, Maria M Plummer
We compared the evidence presented recently that challenges the long-standing belief that, in 1922, two French physicians reported the first case of neurological Lyme disease with a further analysis of the original findings that were translated and re-published in 1993. Alternative possibilities are offered that could explain these discrepant interpretations on what was considered to be a landmark clinical case of historical significance.
April 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28270812/borrelia-burgdorferi-keeps-moving-and-carries-on-a-review-of-borrelial-dissemination-and-invasion
#11
REVIEW
Jenny A Hyde
Borrelia burgdorferi is the etiological agent of Lyme disease, a multisystemic, multistage, inflammatory infection resulting in patients experiencing cardiac, neurological, and arthritic complications when not treated with antibiotics shortly after exposure. The spirochetal bacterium transmits through the Ixodes vector colonizing the dermis of a mammalian host prior to hematogenous dissemination and invasion of distal tissues all the while combating the immune response as it traverses through its pathogenic lifecycle...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28175945/-neuroborreliosis-diagnostics-treatment-and-course
#12
R Dersch, S Rauer
Lyme neuroborreliosis is a tick-borne infectious disease caused by the spirochete bacterium Borrelia burgdorferi sensu lato. Clinical manifestations are classified as early and late Lyme neuroborreliosis. Early manifestations are much more common than late manifestations. Serological testing should only be performed when typical neurological symptoms are present because false positive results are common due to a high seroprevalence in the population. Cerebrospinal fluid (CSF) analysis should be performed if Lyme neuroborreliosis is suspected...
February 7, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28135303/microrna-and-mrna-transcriptome-profiling-in-primary-human-astrocytes-infected-with-borrelia-burgdorferi
#13
Timothy Casselli, Humaira Qureshi, Elizabeth Peterson, Danielle Perley, Emily Blake, Bradley Jokinen, Ata Abbas, Sergei Nechaev, John A Watt, Archana Dhasarathy, Catherine A Brissette
Lyme disease is caused by infection with the bacterium Borrelia burgdorferi (Bb), which is transmitted to humans by deer ticks. The infection manifests usually as a rash and minor systemic symptoms; however, the bacteria can spread to other tissues, causing joint pain, carditis, and neurological symptoms. Lyme neuroborreliosis presents itself in several ways, such as Bell's palsy, meningitis, and encephalitis. The molecular basis for neuroborreliosis is poorly understood. Analysis of the changes in the expression levels of messenger RNAs and non-coding RNAs, including microRNAs, following Bb infection could therefore provide vital information on the pathogenesis and clinical symptoms of neuroborreliosis...
2017: PloS One
https://www.readbyqxmd.com/read/28127071/lyme-neuroborreliosis-in-cases-of-non-specific-neurological-symptoms
#14
Erlend Roaldsnes, Randi Eikeland, Dag Berild
No abstract text is available yet for this article.
January 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28074347/pattern-and-motion-related-visual-evoked-potentials-in-hiv-infected-adults
#15
Jana Szanyi, Jan Kremlacek, Zuzana Kubova, Miroslav Kuba, Pavel Gebousky, Jaroslav Kapla, Juraj Szanyi, Frantisek Vit, Jana Langrova
PURPOSE: The goal of the current study was to explore visual function in virally suppressed HIV patients undergoing combined antiretroviral therapy (cART) by using pattern-reversal and motion-onset visual evoked potentials (VEPs). METHODS: The pattern-reversal and motion-onset VEPs were recorded in 20 adult HIV+ patients with a mean age of 38 years and CD4 cell counts ≥230 × 10(6) cells/L of blood. RESULTS: Nine out of 20 patients displayed VEP abnormalities...
February 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28060695/-extensive-myelitis-as-a-manifestation-of-neuroborreliosis
#16
Ana Brás, Nuno Marques, Beatriz Santiago, Anabela Matos, Fradique Moreira
Neurological manifestations of Lyme disease are reported in 3% - 12% of patients, with the most common form of presentation being meningoradiculitis. Other symptoms involving the central nervous system, such as myelitis or encephalitis, are rare (< 5 %). We report a case of a 66-year-old male, with a subacute extensive transverse myelitis, secondary to Borrelia burgdorferi infection. The patient underwent antibiotic therapy filed for neuroborreliosis with a good clinical outcome. The rareness in clinical symptoms and imaging presentation, based on a treatable infectious disease, highlights the importance of the inclusion of neuroborreliosis in the differential diagnosis of longitudinally extensive transverse myelitis...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28049398/infectious-agents-and-neurodegenerative-diseases-exploring-the-links
#17
REVIEW
Mohammad Zubair Alam, Qamre Alam, Mohammad Amjad Kamal, Asif Ahmad Jiman-Fatani, Esam I Azhar, Mohammad Azhar Khan, Absarul Haque
Recent studies have shown that bacterial and viral infections are risk factors for various neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD), and Lyme disease (LD). However, it is still controversial how the infections play a role in neurological diseases progression. Infections in central nervous system may lead multiple damages in infected and neighboring cells. The infection leads to the activation of inflammatory processes and host immune responses, which acts as defense mechanism and also causes damage to the host neuronal functions and viability...
2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27976670/lyme-borreliosis
#18
REVIEW
Allen C Steere, Franc Strle, Gary P Wormser, Linden T Hu, John A Branda, Joppe W R Hovius, Xin Li, Paul S Mead
Lyme borreliosis is a tick-borne disease that predominantly occurs in temperate regions of the northern hemisphere and is primarily caused by the bacterium Borrelia burgdorferi in North America and Borrelia afzelii or Borrelia garinii in Europe and Asia. Infection usually begins with an expanding skin lesion, known as erythema migrans (referred to as stage 1), which, if untreated, can be followed by early disseminated infection, particularly neurological abnormalities (stage 2), and by late infection, especially arthritis in North America or acrodermatitis chronica atrophicans in Europe (stage 3)...
December 15, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27956736/transplantation-of-human-embryonic-stem-cells-in-patients-with-multiple-sclerosis-and-lyme-disease
#19
Geeta Shroff
BACKGROUND Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease in which the myelin sheath of nerve cells is damaged. It can cause delayed neurologic symptoms similar to those seen in Lyme disease (LD) patients. Thymus derived T-cells (myelin reactive) migrate to the blood brain barrier and stimulate an inflammatory cascade in the central nervous system. Cell based therapies play an important role in treating neurological diseases such as MS and LD. CASE REPORT Human embryonic stem cell (hESC) therapy was used to treat two patients with both MS and LD...
December 13, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27931077/antibiotics-for-the-neurological-complications-of-lyme-disease
#20
REVIEW
Diego Cadavid, Paul G Auwaerter, Jeffrey Rumbaugh, Harald Gelderblom
BACKGROUND: Various central nervous system-penetrant antibiotics are bactericidal in vitro and in vivo against the causative agent of Lyme neuroborreliosis (LNB), Borrelia burgdorferi. These antibiotics are routinely used clinically to treat LNB, but their relative efficacy is not clear. OBJECTIVES: To assess the effects of antibiotics for the treatment of LNB. SEARCH METHODS: On 25 October 2016 we searched the Cochrane Neuromuscular Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase...
December 8, 2016: Cochrane Database of Systematic Reviews
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