Read by QxMD icon Read


Mariko Egawa, Yoshinori Mitamura, Masanori Niki, Hiroki Sano, Gen Miura, Akihiro Chiba, Shuichi Yamamoto, Shozo Sonoda, Taiji Sakamoto
PURPOSE: To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions. METHODS: The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length-matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured...
August 10, 2018: Retina
Gregory Costain, Michal Inbar-Feigenberg, Maha Saleh, Shimrit Yaniv-Salem, Greg Ryan, Eric Morgen, Elaine S Goh, Gen Nishimura, David Chitayat
Traditional approaches to prenatal genetic diagnosis for common presentations such as short femurs or intrauterine growth restriction are imperfect, and whole-exome sequencing is an emerging option. Mucolipidosis type II (I-cell disease) is an ultra-rare autosomal recessive lysosomal storage disorder with the potential for prenatal-onset skeletal and placental manifestations. We describe the prenatal signs in two recent unrelated patients with confirmed diagnoses soon after birth. In both cases, parents were consanguineous but there was no known family history of mucolipidosis type II...
September 2018: Journal of Pediatric Genetics
Brooks B Britt, Fabio M Dalla Vecchia, Daniel J Chure, George F Engelmann, Michael F Whiting, Rodney D Scheetz
Pterosaurs are the oldest known powered flying vertebrates. Originating in the Late Triassic, they thrived to the end of the Cretaceous. Triassic pterosaurs are extraordinarily rare and all but one specimen come from marine deposits in the Alps. A new comparatively large (wing span >150 cm) pterosaur, Caelestiventus hanseni gen. et sp. nov., from Upper Triassic desert deposits of western North America preserves delicate structural and pneumatic details not previously known in early pterosaurs, and allows a reinterpretation of crushed Triassic specimens...
August 13, 2018: Nature Ecology & Evolution
Lei Han, Ren-Fu Quan, Yun-Gen Hu, Wei-Li Fang, Bo Jin, Shi-Chao Xu
Thoracolumbar fractures are common and severe traumas. Anterior approaches can achieve adirect spinal cord decompression and reconstruct anterior column height what load bearing the major load distribution of the spine. Therefore, anterior approach is an important method in the treatment of thoracolumbar fractures. With the application of pedicle screw, most of the patients were treated with posterior approaches.Because of the unique advantages of anterior approach, the posterior approach can not be replaced it...
July 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Chang-Liang Ou, Yong-Gen Zou, Cheng Luo, Xing Zhou, Xu-Chao Luo
OBJECTIVE: To investigate clinical effect of vacuum sealing drainage(VSD) with anterolateral thigh perforator flap for repair foot soft tissue defect. METHODS: From September 2014 to September 2016, 45 patients with foot soft tissue defect repaired by VSD with anterolateral thigh perforator flap, including 31 males and 14 females aged from 17 to 55 years with an average of 36 years old. Thirty patients were dorsal soft tissue defects, and 15 patients were plantar soft tissue defects...
July 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Pan Pan Yue, Gen Que Fu, Ya Jie Hu, Jing Bian, Ming-Fei Li, Zheng-Jun Shi, Feng Peng
To study the differences in chemical composition analysis and spatial distribution of young Neosinocalamus affinis bamboo, we used the method of standard of National Renewable Energy Laboratory and confocal Raman microscopy, respectively. It was found that the acid-soluble lignin and acid-insoluble lignin content showed an inverse relationship with the increasing bamboo age. Raman analysis revealed that Raman signal intensity of lignin both in the secondary cell wall (S) and the compound middle lamella (CML) regions showed a similar increase trend with a growth of bamboo...
August 13, 2018: Journal of Agricultural and Food Chemistry
M Zhang, Q Z Ma, N P Zhai, C Xu, R Zang, Y H Gen, H Y Wu
No abstract text is available yet for this article.
August 10, 2018: Plant Disease
P Peking, J S Breitenbach, M Ablinger, W H Muss, F J Poetschke, T Kocher, U Koller, S Hainzl, S Kitzmueller, J W Bauer, J Reichelt, T Lettner, V Wally
BACKGROUND: Generalized severe epidermolysis bullosa simplex (EBS-gen sev) is a genetic blistering skin disease in which autosomal dominant mutations in either the keratin (KRT) 5 or KRT14 gene lead to impaired function of the intermediate filament cytoskeleton in the basal epidermis. Here, we present an ex vivo RNA trans-splicing-based therapeutic approach to correct the phenotype. OBJECTIVES: We aimed to correct a mutation within exon 1 of the KRT14 gene, using a 5' trans-splicing approach, where any mutation within the first 7 exons could be replaced by a single therapeutic molecule...
August 12, 2018: British Journal of Dermatology
Wei Zhao, Zhao-Hong Peng, Jin-Zhou Chen, Ji-Hong Hu, Jian-Qiang Huang, Yong-Neng Jiang, Gang Luo, Gen-Fa Yi, Hui Wang, Shen Jin, Bu-Lang Gao
Purpose: To investigate effects and heat distribution of radiofrequency ablation (RFA) on vertebral tumors in vitro and in vivo swine experiments and its clinical application. Materials and methods: RFA was performed on the swine spine in vitro and in vivo for 20 min at 90 °C at the electrode tip, and the temperature at the electrode tip and surrounding tissues were recorded. Clinical application of ablation combined with vertebroplasty was subsequently performed in 4 patients with spinal tumors...
September 2018: Journal of Bone Oncology
Shohei Kobayashi, Nanamo Aokura, Ryohei Fujimoto, Keisuke Mori, Yoshinori Kumazawa, Yusuke Ando, Tsuyoshi Matsuda, Hiroshi Nitto, Katsuhiko Arai, Gen Watanabe, Tomomi Saito
Artificial manipulation of incubation temperature has been proposed as a potential strategy for mitigating the effects of climate change on sea turtles for which sex determination is temperature-dependent, but thermal manipulation may also affect hatchling survival. Here, we demonstrated that incubation and water temperatures influenced several performance traits that contribute to the survival of loggerhead sea turtles (Caretta caretta) during the post-hatchling dispersal phase. Hatchlings from warm incubation temperatures (31 °C) had significantly shorter incubation periods, higher initial swimming performance, lower sustained swimming performance, and lower growth rates during the first three weeks post-hatching, as well as higher blood glucose concentrations, than those from cool incubation temperatures (27...
August 9, 2018: Scientific Reports
Liu-Gen Jin, Si Zeng, Xue-Qian Sun, Chen Wu, Jun-Liang Chen, Meng Cui, Qing-Feng Pang
OBJECTIVE: Resident alveolar macrophages (AMs) are activated and release proinflammatory mediators and chemokines during acute lung injury. We have previous reported that caveolin-1 (Cav-1) scaffolding domain (CSD) peptide inhibited the proinflammatory cytokines expression by up-regulating heme oxygenase-1 (HO-1) activity. In this study, we aimed to investigate the effect of residue R101 in CSD peptide on the activity of HO-1 in AMs. METHODS: The binding mode between HO-1 and CSD peptides (WT CSD and Δ101 CSD truncation peptides) was analyzed and the free energy was calculated...
August 6, 2018: International Immunopharmacology
Nereida Mestre-Novoa, Takumasa Kondo
A new neotropical genus and species of soft scale insect from Cuba, Hamonicoccus Mestre and Kondo gen. nov. is described and Hamonicoccus alayoi Mestre and Kondo sp. nov. (Hemiptera: Coccomorpha: Coccidae) is described and illustrated based on the adult female. The species was collected in Cayos de las Cinco Leguas, Matanzas Province, on Capparis cynophallophora (Capparaceae), and in Surgidero de Batabanó, Mayabeque Province, on Rhizophora mangle (Rhizophoraceae). The affinities of H alayoi sp. nov. with closely related species is discussed based on published literature...
2018: International Journal of Insect Science
Yang Li, Dan-Yun Ruan, Chang-Chang Jia, Jun Zheng, Guo-Ying Wang, Hui Zhao, Qing Yang, Wei Liu, Shu-Hong Yi, Hua Li, Gen-Shu Wang, Yang Yang, Gui-Hua Chen, Qi Zhang
Hepatic ischemia-reperfusion (I/R) injury fundamentally influences the performance of aged liver grafts. The significance of mitophagy in the age dependence of sensitivity to I/R injury remains poorly understood. Here, we show that aging aggravated hepatic I/R injury with decreased mitophagy in mice. The enhancement of mitophagy resulted in significant protection against hepatic I/R injury. Parkin, an E3 ubiquitin ligase, was found depleted by I/R in aged livers. In oxygen-glucose deprivation reperfusion (OGD-Rep...
August 8, 2018: Aging
Annette Klein, Elke Zimmermann, Ute Radespiel, Frank Schaarschmidt, Andrea Springer, Christina Strube
BACKGROUND: Ectoparasitic infections are of particular interest for endangered wildlife, as ectoparasites are potential vectors for inter- and intraspecific pathogen transmission and may be indicators to assess the health status of endangered populations. Here, ectoparasite dynamics in sympatric populations of two Malagasy mouse lemur species, Microcebus murinus and M. ravelobensis, were investigated over an 11-month period. Furthermore, the animals' body mass was determined as an indicator of body condition, reflecting seasonal and environmental challenges...
August 8, 2018: Parasites & Vectors
Hirohisa Watanabe, Yuichi Riku, Kazuhiro Hara, Kazuya Kawabata, Tomohiko Nakamura, Mizuki Ito, Masaaki Hirayama, Mari Yoshida, Masahisa Katsuno, Gen Sobue
Multiple system atrophy (MSA) is an adult-onset, progressive neurodegenerative disorder. Patients with MSA show various phenotypes during the course of their illness, including parkinsonism, cerebellar ataxia, autonomic failure, and pyramidal signs. Patients with MSA sometimes present with isolated autonomic failure or motor symptoms/ signs. The median duration from onset to the concomitant appearance of motor and autonomic symptoms is approximately 2 years but can range up to 14 years. As the presence of both motor and autonomic symptoms is essential for the current diagnostic criteria, early diagnosis is difficult when patients present with isolated autonomic failure or motor symptoms/signs...
August 9, 2018: Journal of Movement Disorders
Elizabeth G Moore, Myra Roche, Christine Rini, Edward W Corty, Zahra Girnary, Julianne M O'Daniel, Feng-Chang Lin, Giselle Corbie-Smith, James P Evans, Gail E Henderson, Jonathan S Berg
BACKGROUND/AIMS: Recent genomic medicine initiatives underscore the importance of including diverse participants in research. Considerable literature has identified barriers to and facilitators of increasing diversity, yet disparities in recruiting and retaining adequate numbers of participants from diverse groups continue to limit the generalizability of clinical genomic research. METHODS: The North Carolina Clinical Genomic Evaluation by Next-gen Exome Sequencing study employed evidence-based strategies to enhance the participation of under-represented minority patients...
August 7, 2018: Public Health Genomics
Terry A Gates, Khishigjav Tsogtbaatar, Lindsay E Zanno, Tsogtbaatar Chinzorig, Mahito Watabe
We describe a new iguanodontian ornithopod, Choyrodon barsboldi gen. et sp. nov. from the Albian-aged Khuren Dukh Formation of Mongolia based on several partial skeletons interpreted to represent a subadult growth stage based on osteohistological features. This new taxon is diagnosed by many autapomorphies of the maxilla, nasal, lacrimal, opisthotic, predentary, and surangular. Choyrodon displays an unusual combination of traits, possessing an open antorbital fenestra (a primitive ornithopod trait) together with derived features such as a downturned dentary and enlarged narial fenestra...
2018: PeerJ
Yanmao Wang, Gen Wen, Runhua Zhou, Wanrun Zhong, Shengdi Lu, Chengfang Hu, Yimin Chai
Objective: Nonalcoholic fatty liver disease (NAFLD) is related to several inflammatory or metabolic diseases. However, findings of previous studies investigating the association between NAFLD and BMD are inconsistent. Only one study reported a potential association between NAFLD and osteoporotic fracture. This study investigated whether NAFLD in older participants (>55 years) was associated with osteoporotic fracture risk. Materials and Methods: This cross-sectional, observational study included 2,695 participants (35...
2018: Frontiers in Endocrinology
Mami Fukuma, Masaki Takagi, Tomoyuki Shimazu, Hoseki Imamura, Hiroko Yagi, Gen Nishimura, Tomonobu Hasegawa
No abstract text is available yet for this article.
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
Gen Suzuki, Hideya Yamazaki, Norihiro Aibe, Koji Masui, Daisuke Shimizu, Takuya Kimoto, Takeshi Nishimura, Akihiro Nakashima, Tadashi Takenaka, Osamu Dohi, Takeshi Ishikawa, Kei Yamada
Several therapeutic options are available for clinical T1N0M0 thoracic esophageal squamous cell carcinoma (stage I ESCC); however, the studies on the treatment results are limited. This study assessed the outcomes of stage I ESCC treated with radiotherapy (RT), determined predictive factors, and evaluated the benefits of endoscopic submucosal dissection (ESD) combined with RT. We retrospectively analyzed the data of 50 patients (41 men, 9 women; median age, 66 years) with stage I ESCC treated with RT. The median total irradiation dose was 50 Gy...
August 3, 2018: Cancers
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"