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Ping Song, Fa-Liang Duan, Qiang Cai, Jing-Lei Wu, Xiao-Bin Chen, Yuan Wang, Cong-Gang Huang, Ji-Qiang Li, Zhu-Qiang He, Qiao-Chun Huang, Mei Liu, Yan-Gao Zhang, Ming Luo
The efficacy and applied value of endoscopic hematoma evacuation vs. external ventricular drainage (EVD) in the treatment of severe ventricular hemorrhage (IVH) were explored and compared. From Jan. 2015 to Dec. 2016, the clinical data of 42 cases of IVH were retrospectively analyzed, including 18 patients undergoing endoscopic hematoma evacuation (group A), and 24 patients receiving EVD (group B). The hematoma clearance rate was calculated by 3D Slicer software, and complications and outcomes were compared between the two groups...
October 2018: Current medical science
D Intiso, A Fontana, M Copetti, F Di Rienzo
BACKGROUND: Vitamin D may be important for the development and function of the nervous system. Low serum vitamin D levels have been detected in several neurological diseases. OBJECTIVE: To ascertain the relationship between 25(OH)D serum level and disability in subjects with severe acquired brain injury (sABI). DESIGN: Prospective cross-sectional study Methods: Consecutive subjects with sABI admitted to neuro-rehabilitation were enrolled. A sample of subjects from the neurological ward was considered the control group...
October 19, 2018: Brain Injury: [BI]
Dandan Li, Jian Li, Bin Jia, Yue Wang, Juxin Zhang, Guangzhi Liu
PROBLEM: This study revealed miRNA regulation and functional microarray-based profiles of miRNAs in the natural killer (NK) cells of the decidual tissue obtained from patients with unexplained recurrent spontaneous abortion (URSA). METHOD OF STUDY: Patients with URSA were categorized based on the occurrence of at least two or more successive spontaneous abortions between 7th and 10th gestational week. Total RNA was isolated from the NK cells of the decidual tissue obtained from patients with induced abortion at about the 8th gestational week...
October 19, 2018: American Journal of Reproductive Immunology: AJRI
Guilherme Gozzoli Podolsky-Gondim, Luciano Lopes Furlanetti, Dinark Conceição Viana, Matheus Fernando Manzolli Ballestero, Ricardo Santos de Oliveira
INTRODUCTION: Head injury is a significant economic, social, and medical problem in developing countries and remains one of the leading causes of pediatric morbidity and mortality. The association of traumatic brain injury and coagulopathy in children is linked with an increase in mortality and poor functional outcomes. However, its impact on long-term outcome has not been discussed in the literature so far. OBJECTIVES: The aim of this paper was to investigate the effect of coagulopathy diagnosed by routine laboratory tests on neurological outcome following traumatic brain injury in children...
October 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Jason W Arnold, Joshua B Simpson, Jeffery Roach, Jose M Bruno-Barcena, M Andrea Azcarate-Peril
Lactose intolerance, characterized by a decrease in host lactase expression, affects approximately 75% of the world population. Galacto-oligosaccharides (GOS) are prebiotics that have been shown to alleviate symptoms of lactose intolerance and to modulate the intestinal microbiota, promoting the growth of beneficial microorganisms. We hypothesized that mechanisms of GOS utilization by intestinal bacteria are variable, impacting efficacy and response, with differences occurring at the strain level. This study aimed to determine the mechanisms by which human-derived Lactobacillus rhamnosus strains metabolize GOS...
October 16, 2018: Nutrients
Yan Yan, Jian Song, Shun Yao, Yusong Gao, Guibao Peng, Chenglong Cao, Wei Liao, Wan Yang, Zhixian Lan, Haiyang Xie, He Huang, Hao Du, Guozheng Xu
BACKGROUND: To develop and validate a refined traumatic brain injury (TBI) classification system to supplement the existing systems which have limited accuracy for predicting long-term consciousness recovery. METHODS: The refined classification system was developed using medical records of 527 patients according to clinical presentations within 12-24 hrs after injury. Multiple linear regression was applied to identify protective and risk factors for Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) score at 12-month follow-up...
October 16, 2018: Brain Injury: [BI]
Sander Bus, Dagmar Verbaan, Bertjan J Kerklaan, Marieke E S Sprengers, William P Vandertop, Jan Stam, Gerrit J Bouma, Pepijn van den Munckhof
PURPOSE: According to the international guidelines, acute subdural hematomas (aSDH) with a thickness of >10 mm, or causing a midline shift of >5 mm, should be surgically evacuated. However, high mortality rates in older patients resulted in ongoing controversy whether elderly patients benefit from surgery. We identified predictors of outcome in a single-centre cohort of elderly patients undergoing surgical evacuation of aSDH or subacute subdural hematoma (saSDH). MATERIALS AND METHODS: This retrospective study included all patients aged ≥65 years undergoing surgical evacuation of aSDH/saSDH from 2000 to 2015...
October 13, 2018: British Journal of Neurosurgery
Sophie Fehlbaum, Kevin Prudence, Jasper Kieboom, Margreet Heerikhuisen, Tim van den Broek, Frank H J Schuren, Robert E Steinert, Daniel Raederstorff
Recently, the concept of prebiotics has been revisited to expand beyond non-digestible oligosaccharides, and the requirements for selective stimulation were extended to include microbial groups other than, and additional to, bifidobacteria and lactobacilli. Here, the gut microbiota-modulating effects of well-known and novel prebiotics were studied. An in vitro fermentation screening platform (i-screen) was inoculated with adult fecal microbiota, exposed to different dietary fibers that had a range of concentrations (inulin, alpha-linked galacto-oligosaccharides (alpha-GOS), beta-linked GOS, xylo-oligosaccharides (XOS) from corn cobs and high-fiber sugar cane, and beta-glucan from oats), and compared to a positive fructo-oligosaccharide (FOS) control and a negative control (no fiber addition)...
October 10, 2018: International Journal of Molecular Sciences
Lais Pardini, Mariana Bernstein, Liliana A Carral, Federico J Kaufer, Andrea Dellarupe, María L Gos, Lucía M Campero, Gastón Moré, Matías Tomás Messina, María Vanessa Schneider, Cristina B Freuler, Ricardo A Durlach, Juan M Unzaga, María C Venturini
Toxoplasmosis, a worldwide distributed zoonosis, can be transmitted congenitally affecting fetuses and developing variable clinical signs. Different Toxoplasma gondii genotypes and infective dose are related factors with different clinical manifestations. Several studies indicate that atypical strains could produce more severe clinical manifestations compared to typical strains. Umbilical cord blood (n = 37) and placenta (n = 19) were collected at birth from women with acute T. gondii infection and processed for isolation by mice bioassay...
October 7, 2018: Parasitology International
Chii-Rong Yang, Shih-Feng Tseng, Yu-Ting Chen
The chemical oxidation method can be used to mass-produce graphene oxides (GOs) from highly oriented pyrolytic graphite. However, numerous oxygen-containing functional groups (hydroxyl, epoxy, carbonyl, etc.) exist in typical GO surfaces, resulting in serious electrical losses. Hence, GO must be processed into reduced graphene oxide (rGO) by the removal of most of the oxygen-containing functional groups. This research concentrates on the reduction efficiency of GO films that are manufactured using atmospheric-pressure and continuous plasma irradiation...
October 8, 2018: Nanomaterials
Carlos Sabater, Agustina Fara, Jorge Palacios, Nieves Corzo, Teresa Requena, Antonia Montilla, Gabriela Zárate
The potential of probiotic bacteria to produce prebiotic oligosaccharides by transgalactosylation has been minimally studied. In this work, we screened the β-galactosidase (β-gal) activity of dairy propionibacteria (PAB) isolated from Argentinean foods to select strains for the synthesis of oligosaccharides from lactose (GOS) and lactulose (OsLu). PAB, when grown in a medium with lactose as a carbon source, were disrupted, and the cell-free extracts were assayed for β-gal activity. Nine strains grew on lactose and showed β-gal activities from 0...
February 2019: Food Microbiology
Jun-Ho Ahn, Sung-Hee Hwang, Hyun-Soo Cho, Michael Lee
Melanoma cells have been shown to respond to BRAF inhibitors; however, intrinsic and acquired resistance limits their clinical application. In this study, we performed RNA-Seq analysis with BRAF inhibitor-sensitive (A375P) and -resistant (A375P/Mdr with acquired resistance and SK-MEL-2 with intrinsic resistance) melanoma cell lines, to reveal the genes and pathways potentially involved in intrinsic and acquired resistance to BRAF inhibitors. A total of 546 differentially expressed genes (DEGs), including 239 up-regulated and 307 down-regulated genes, were identified in both intrinsic and acquired resistant cells...
October 4, 2018: Biomolecules & Therapeutics
Hong Guo, Raynald Liu, Zhaosheng Sun, Bing Liu, Yi Xiang, Jianhui Mao, Guangjie Li, Mingzhe Zhang
BACKGROUND: Our study is aimed to investigate the change of the default-mode network (DMN) by using Amplitude of Low-Frequency Fluctuation (ALFF) and functional connectivity (FC) methods in acute phase patients after severe traumatic brain injury (sTBI) and to correlate these changes with its prognosis. METHODS: Twenty one patients with severe traumatic brain injury were included in this study. Gender, age and education matched controls were participated in this study...
October 3, 2018: World Neurosurgery
Zhigang Lan, Seidu A Richard, Lu Ma, Chaohua Yang
Background: Nonmissile anterior skull-base penetrating brain injuries (NASBPBIs) have specific characteristic features that are different from missile injuries. Our study presents our experiences on the characteristic features as well as management of NASBPBI. Materials and Methods: We retrospectively reviewed 22 consecutive patients with NASBPBI managed at our institute during a 13-year period. The mechanism of injury, clinical investigations, and complications were analyzed, with more emphasis on diagnostic and treatment regimen...
July 2018: Asian Journal of Neurosurgery
Prajakta Suresh Ghate, Ashok Bhanage, Hrishikesh Sarkar, Anand Katkar
Background: Severe traumatic brain injury (TBI) is associated with disabling cognitive impairment. Currently available options to improve the cognitive function have been futile. However, recently, commonly used medicine for Parkinson's disease, amantadine, has been shown to assist in the improvement of cognitive function. Methodology: We conducted a single institution-based observational study in adult Indian population. Fifty consecutive patients with documented static or declining cognitive function at 2 months of severe TBI fulfilling the inclusion/exclusion criteria received amantadine 200 mg/day (100 mg twice a day) orally or through enteral feeding tube for the duration of 4 weeks...
July 2018: Asian Journal of Neurosurgery
Hamed Zaer, Baskaran Ketharanathan, Jakob G Carlsen, Shima Shahbazi, Jens C Hedemann Sørensen
AIM AND CLINICAL RATIONALE FOR THE STUDY: Spontaneous intracerebral haemorrhage (sICH) is an acute life-threatening injury and constitutes 10-15% of first-ever stroke cases. The Surgical Trials in Intracerebral Haematoma studies (STICH and STICH II) represent the two foremost studies in the field, however, with arguable shortcomings. To find more accurate criteria, we aimed to correlate the preoperative neurological and neuroimaging findings with the clinical outcome of operated patients...
September 24, 2018: Neurologia i Neurochirurgia Polska
Roberto Brusati, Maria Costanza Meazzini, Angela Rezzonico, Federico Biglioli, Giovanna Garattini, Valeria Marinella Augusta Battista, Luca Autelitano
The aim of this paper was to assess growth, speech, and aesthetic results at the completion of growth in patients with unilateral cleft lip and palate treated with the 2 stages Milan surgical protocol.Craniofacial growth was evaluated with cephalometric analysis and a theoretical need for orthognathic surgery.Nasolabial appearance was qualitatively assessed using the Asher McDade Aesthetic Index.Speech was assessed using the Gos.Sp.Ass '98 modified for Italian language scoring system.Burden of care was recorded in terms of number of secondary surgical procedures...
October 1, 2018: Journal of Craniofacial Surgery
Jesús Quetzalcoatl Beltrán, Julian Eduardo Soto-Abraham, Jorge Vidaurreta-Serrano, Laura Graciela Chavez Macias, Erick Gómez Apo, Elizabeth Ogando-Rivas
Objective: The authors aimed to analyze the current epidemiology of high- and low-grade gliomas, follow-up strategies, and prognosis in a national reference center of a developing country. Materials and Methods: Medical records of patients diagnosed with intracranial gliomas from January 2012 to January 2016 were reviewed. Data were classified by age, symptoms, Karnofsky functional scale (KFS), tumor location, extent of resection (EOR), histopathology, hospital stay, Glasgow outcome scale (GOS), adjuvant treatments, overall survival (OS), and mortality...
October 2018: Journal of Neurosciences in Rural Practice
Jung Il Kwon, Yooheon Park, Dong Ouk Noh, Hyung Joo Suh, Sung Hee Han
The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats...
June 2018: Food Science and Biotechnology
Abbas Mohammadi, Amir Hossein Doctorsafaei, Khalid Mahmood Zia
The present study reports the preparation of novel alginate/calix[4]arenes modified graphene oxide nanocomposite beads (alginate/C4As-GOs) based on p-tert-butyl calix[4]arene and sodium p-sulfonatocalix[4]arene modified GO nanosheets (CGO and SGO). Different properties of alginate/GO and alginate/C4As-GOs nanocomposite beads were investigated by FTIR, XRD, TGA, SEM, and swelling ratio analysis. The alginate beads containing SGO nanosheets (ABSGO) showed a thin layered structure, high porosity, and high swelling ratio compared to other samples...
September 24, 2018: International Journal of Biological Macromolecules
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