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https://www.readbyqxmd.com/read/29155140/pregnancy-and-parturition-negatively-impact-vaginal-angle-and-alters-expression-of-vaginal-mmp-9
#1
Sallie Oliphant, Timothy Canavan, Stacy Palcsey, Leslie Meyn, Pamela Moalli
BACKGROUND: Parity is the greatest risk factor for the development of pelvic organ prolapse. The normally supported vagina is pulled up and back over the levator ani. Loss of vaginal angulation has been associated with prolapse and may represent injury to the vaginal supportive tissues. OBJECTIVE: We propose that 1) pregnancy and delivery impact support to the vagina leading to loss of vaginal angle; 2) vaginal angulation is restored postpartum; and 3) uncomplicated vaginal delivery (VD) is associated with accelerated remodeling of the vaginal fibrillar matrix...
November 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29151321/multiplex-pcr-detection-of-problematic-pathogens-of-clinically-heterogeneous-bacterial-vaginosis-in-bulgarian-women
#2
Konstantsa Tosheva-Daskalova, Tanya Vasileva Strateva, Ivan Gergov Mitov, Raina Tzvetanova Gergova
Background/aim: This study aimed to investigate the correlation between the prevalence of problematic pathogens and the clinical status of women with bacterial vaginosis (BV). Materials and methods: Gardnerella vaginalis, Atopobium vaginae, and Mobiluncus spp. were detected using a multiplex PCR assay, and their role in the infection of Bulgarian women with clinically heterogeneous BV was evaluated. Results: The predominant BV-associated pathogen identified was G. vaginalis with an incidence of 98.39%, followed by A...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29149907/mapping-evidence-on-the-distribution-of-human-papillomavirus-related-cancers-in-sub-saharan-africa-scoping-review-protocol
#3
Bridget K M Lekoane, Tivani P Mashamba-Thompson, Themba G Ginindza
BACKGROUND: Despite the introduction of HPV vaccines, the incidence of HPV-related cancers (cervical, penile, anal, vulvar, vagina, head, and neck) in sub-Saharan Africa has been rising. The increasing incidence of these HPV-related cancers has been attributed to changes in lifestyle-related risk factors, most notably sexual behavior. The main objective of this study is to map evidence on the distribution of HIV-related cancers in sub-Saharan Africa (SSA). METHODS AND ANALYSIS: We will conduct a scoping review to explore, describe, and map literature on the distribution of HPV-related cancers in sub-Saharan Africa...
November 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29146542/development-of-a-mucoadhesive-delivery-system-for-control-release-of-doxepin-with-application-in-vaginal-pain-relief-associated-with-gynecological-surgery
#4
Roser Sanz, Beatriz Clares, Mireia Mallandrich, Joaquim Suñer-Carbó, María Jesús Montes, Ana C Calpena
The main purpose of this study was to develop a semisolid mucoadhesive formulation for the non-invasive vaginal administration of doxepin (DOX) for pain relief derived from the scarring process after surgery. An orafix(®) platform loading DOX was tested for adequate stability, rheology and vaginal mucoadhesion capacity. The formulation exhibited appropriate pH and was microbiologically stable. The rheological studies confirmed its pseudoplastic and thixotropic nature with prevalence of the elastic behavior component over the viscous one...
November 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29138104/novel-mixed-vesicles-containing-lactobacilli-biosurfactant-for-vaginal-delivery-of-an-anti-candida-agent
#5
Angela Abruzzo, Barbara Giordani, Carola Parolin, Beatrice Vitali, Michele Protti, Laura Mercolini, Martina Cappelletti, Stefano Fedi, Federica Bigucci, Teresa Cerchiara, Barbara Luppi
The purpose of this work was to prepare and characterize an innovative formulation for vaginal delivery of econazole nitrate, commonly used for the treatment of Candida infections. A novel biosurfactant isolated from a vaginal Lactobacillus strain was used to prepare phosphatidylcholine based mixed vesicles. Biosurfactant was produced by Lactobacillus gasseri BC9, isolated from the vagina of a healthy premenopausal woman, and was chemically characterized by FT-IR and ESI-MS. Mixed vesicles, obtained through film rehydration and extrusion method, were characterized in terms of size, zeta potential, encapsulation efficiency, mucoadhesion properties and econazole release...
November 11, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29135136/-structural-morphological-changes-of-the-connective-tissue-of-the-vaginal-mucosa-and-perineal-skin-in-women-with-stress-urinary-incontinence
#6
V N Pavlov, A G Yashchuk, A A Kazikhinurov, I I Musin, R M Zauinullina, V A Kulavskii, A A Kazikhinurova
AIM: To investigate the morphological and structural changes in the connective tissue of the vaginal mucosa and perineal skin in women with stress urinary incontinence. MATERIALS AND METHODS: From 2010 to 2013, 71 patients of reproductive age with stress incontinence were observed. The control group comprised 80 women, who also underwent biopsy of the vaginal mucosa and perineal skin. The sections of specimens were stained by Van Gieson, Mallory and Weigert. In immunohistochemical studies, rabbit antibodies specific for collagen types I, III, and IV were placed on each section...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29134627/the-evolution-of-genital-shape-variation-in-female-cetaceans
#7
Dara N Orbach, Brandon Hedrick, Bernd Würsig, Sarah L Mesnick, Patricia Lr Brennan
Male genital diversification is likely the result of sexual selection. Female genital diversification may also result from sexual selection, although it is less well studied and understood. Female genitalia are complex among whales, dolphins, and porpoises, especially compared to other vertebrates. The evolutionary factors affecting the diversity of vaginal complexity could include ontogeny, allometry, phylogeny, sexual selection, and natural selection. We quantified shape variation in female genitalia using 2-D geometric morphometric analysis, and validated the application of this method to study soft tissues...
November 14, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29134243/-implants-for-genital-prolapse-pro-mesh-surgery
#8
REVIEW
J Neymeyer, D-E Moldovan, K Kornienko, K Miller, A Weichert
There has been an overall increase in pelvic organ prolapse due to demographic changes (increased life expectancy). Increasing sociocultural demands of women require treatments that are more effective with methods that are more successful. In the treatment of pelvic floor insufficiency and uterovaginal prolapse, pelvic floor reconstructions with mesh implants have proven to be superior to conventional methods such as the classic colporrhaphy, reconstructions with biomaterial, and native tissue repair in appropriately selected patients and when applying exact operation techniques, especially because of good long-term results and low recurrence rates...
November 13, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29134005/taxonomic-study-of-the-genus-neocarpia-tsaur-hsu-with-descriptions-of-two-new-species-from-china-hemiptera-fulgoromorpha-cixiidae
#9
Yan Zhi, Lin Yang, Pei Zhang, Xiang-Sheng Chen
The cixiid planthoppers genus Neocarpia Tsaur & Hsu, 2003 is reviewed. Two new species, N. acutata Zhi & Chen, sp. n. and N. reversa Zhi & Chen, sp. n., are described and illustrated from the southwest of China (Yunnan) to give the genus seven species in total. Female genitalia of four Chinese species are described and illustrated for the first time. A key to all known species of Neocarpia based on male genitalia, and a key to Chinese species (except for N. maai) based on female genitalia, are provided. The morphological characteristics of the posterior vagina, utilized to distinguish female species of Neocarpia, are also discussed...
2017: ZooKeys
https://www.readbyqxmd.com/read/29131032/anti-psoriasis-effects-and-mechanisms-of-%C3%AE-8-quinolinoxy-zinc-phthalocyanine-mediated-photodynamic-therapy
#10
Han-Qing Liu, Ying-Ming Wang, Wan-Fang Li, Chao Li, Zhi-Huan Jiang, Jie Bao, Jin-Feng Wei, Hong-Tao Jin, Ai-Ping Wang
BACKGROUND/AIMS: The aim of this study was to determine the anti-psoriasis effects of α-(8-quinolinoxy) zinc phthalocyanine (ZnPc-F7)-mediated photodynamic therapy (PDT) and to reveal its mechanisms. METHODS: HaCaT cells were used to observe the influence of ZnPc-F7-PDT on cell proliferation in vitro. The in vivo anti-psoriasis effects of ZnPc-F7-PDT were evaluated using a mouse vagina model, a propranolol-induced cavy psoriasis model and an imiquimod (IMQ)-induced nude mouse psoriasis model...
November 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29117923/genital-injuries-acute-evaluation-and-management
#11
REVIEW
Heather N Lopez, Mariel A Focseneanu, Diane F Merritt
Genital trauma may result in external injuries to the labia, vulva or vagina, urethra and anus and internal injuries to the bony pelvis, bladder, bowels and reproductive organs. Worldwide, the most common cause of genital trauma in reproductive age women is injury sustained during childbirth, but in this chapter we will focus on accidental genital injuries as well as those arising from sexual violence, and female genital mutilation. While genital injuries alone rarely result in death; if not properly managed, chronic discomfort, dyspareunia, infertility, or fistula formation may result...
September 28, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29117653/effect-of-delivery-and-episiotomy-on-the-emergence-of-urinary-incontinence-in-women-review-of-literature
#12
Krešimir Živković, Nikica Živković, Tomislav Župić, Damir Hodžić, Vjekoslav Mandić, Slavko Orešković
Episiotomy is obstetric procedure during which the incision extends the vestibule of the vagina during the second stage of labor. Episiotomy was extensively spread with gradual increase of rates in the first half of the 20th century and was performed medio-laterally in all nulliparous women with the idea to protect fetal head from trauma and pelvic floor from injuries. However, reports claiming that episiotomy had no such benefits were published. It was shown that routine medio-lateral episiotomy did not protect against the appearance of urinary incontinence after vaginal delivery, while the risk of anal incontinence could be increased...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29114268/vaginal-fluid-urea-and-creatinine-in-the-diagnosis-of-premature-rupture-of-membranes-in-resource-limited-community-settings
#13
Jasmina Begum, Sunil Kumar Samal, Seetesh Ghose, Gopal Niranjan
Objective: Diagnosis of premature rupture of membranes (PROM) is difficult in equivocal cases with traditional methods. This study aimed to evaluate the reliability of vaginal washing fluid urea and creatinine for diagnosis of PROM and to determine the cut off value. Materials and methods: The current study was a prospective case control. Women having gestational age of 28 to 42 weeks were divided into two equal groups: Fifty with history of leaking per vagina (study group) and an equal number with gestation matched none leaking (control group) were recruited...
March 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/29113647/super-radical-hysterectomy-for-recurrent-cervical-cancer
#14
Hee Seung Kim, Ranah Kim, Maria Lee
BACKGROUND: Recurrent cervical cancer with the pelvic side wall invasion has a deleterious effect on prognosis if there is no alternative method to achieve local tumor control [1, 2]. For the surgical treatment, super-radical hysterectomy has been introduced by Ryukichi Mibayashi in 1941 [3, 4]. However, its feasibility and safety is still on debate because of a lack of reproducibility and high level of surgical techniques. Thus, we showed the surgical procedure of super-radical hysterectomy for recurrent cervical cancer...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29109863/pattern-of-gynaecological-malignancies-in-south-western-region-of-pakistan-an-overview-of-12-years
#15
Hina Manzoor, Hamida Naheed, Khushnaseeb Ahmad, Shehla Iftikhar, Muhammad Asif, Jamila Shuja, Neelam Sultan, Irfan Ali, Syed Inayatullah, Yasir Hayat Khan
Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and morbidity. The aim of this retrospective study was to determine the pattern of gynaecological malignancies identified between January, 2000 and December, 2011, at the Centre for Nuclear Medicine and Radiotherapy (CENAR). At CENAR 5,072 female patients were registered with different malignancies, of which 632 cases were gynaecological malignancies. Ovarian cancer (47%) was the most common gynaecological malignancy, followed by cervical cancer (29%), uterine cancer (14%), vulvar and vaginal cancer (6%), and gestational trophoblastic neoplasm (4%)...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29108861/a-slippery-slope-on-the-origin-role-and-physiology-of-mucus
#16
Farhan Taherali, Felipe Varum, Abdul W Basit
The mucosa of the gastrointestinal tract, eyes, nose, lungs, cervix and vagina is lined by epithelium interspersed with mucus-secreting goblet cells, all of which contribute to their unique functions. This mucus provides an integral defence to the epithelium against noxious agents and pathogens. However, it can equally act as a barrier to drugs and delivery systems targeting epithelial passive and active transport mechanisms. This review highlights the various mucins expressed at different mucosal surfaces on the human body, and their role in creating a mucoid architecture to protect epithelia with specialized functions...
November 3, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29106748/solitary-fibrous-tumor-of-the-female-genital-tract-a-clinicopathologic-analysis-of-25-cases
#17
Eric J Yang, Brooke E Howitt, Christopher Dm Fletcher, Marisa R Nucci
AIMS: Solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm of fibroblastic origin, first described as a tumor of the pleura and now well established at extrapleural sites. However, SFT in the female genital tract is rare and therefore not fully characterized. MATERIAL AND RESULTS: We describe a series of 25 SFTs arising throughout the gynecologic tract, including vulva (14 cases), vagina (1), cervix (1), uterus (6), ovary (2) and fallopian tube (1)...
November 6, 2017: Histopathology
https://www.readbyqxmd.com/read/29098108/vaginal-cuff-dehiscence-presenting-with-free-air-60-days-after-robotic-assisted-hysterectomy
#18
D Munger, M Iannamorelli, C Galvez, C Service
Introduction: The vast majority of patients presenting with pneumoperitoneum have visceral organ perforation and require urgent diagnostic laparoscopy. Nonsurgical causes are relatively rare and may be attributed to multiple etiologies. Case Presentation: Here we describe the case of a 38-year-old Caucasian female who presented to the emergency department with three days of cramping, epigastric abdominal pain. Her physical exam was notable for tenderness to palpation in the epigastric area and abdominal and chest X-rays showed free air under the diaphragm...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29095775/vaginal-foreign-bodies-the-potential-role-of-point-of-care-ultrasound-in-the-pediatric-emergency-department
#19
Isabel Theresia Gross, Antonio Riera
Transabdominal point-of-care ultrasound may be a helpful tool during the evaluation of children with suspected vaginal foreign bodies. We discuss the case of an 11-year-old girl presenting after having placed a pen into her vagina. The patient attempted to remove the pen, but there was concern the cap may have been retained in the vagina. Point-of-care ultrasound findings confirmed a retained pen cap that was subsequently removed by pediatric surgery. We discuss the role of transabdominal point-of-care ultrasound for the detection of vaginal foreign bodies in pediatric patients...
November 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29077897/in-vivo-oxygen-temperature-and-ph-dynamics-in-the-female-reproductive-tract-and-their-importance-in-human-conception-a-systematic-review
#20
Ka Ying Bonnie Ng, Roel Mingels, Hywel Morgan, Nick Macklon, Ying Cheong
BACKGROUND: Despite advances in ART, implantation and pregnancy rates per embryo transfer still remain low. IVF laboratories strive to ensure that the process of handling gametes in vitro closely mimics the in vivo environment. However, there remains a lack of knowledge regarding the in vivo regulation and dynamic variation in biophysical parameters such as oxygen concentration, pH and temperature within the reproductive tract. OBJECTIVE AND RATIONALE: To undertake a systematic review of the current understanding of the physico-chemical parameters of oxygen tension (pO2), pH and temperature within the female reproductive tract, and their potential implications in clinical and pathological processes related to fertility and those pertaining to limited reproductive capacity...
October 25, 2017: Human Reproduction Update
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