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https://www.readbyqxmd.com/read/28447562/dosimetric-advantages-of-a-clinical-daily-adaptive-plan-selection-strategy-compared-with-a-non-adaptive-strategy-in-cervical-cancer-radiation-therapy
#1
Agustinus J A J van de Schoot, Peter de Boer, Jorrit Visser, Lukas J A Stalpers, Coen R N Rasch, Arjan Bel
BACKGROUND: Radiation therapy (RT) using a daily plan selection adaptive strategy can be applied to account for interfraction organ motion while limiting organ at risk dose. The aim of this study was to quantify the dosimetric consequences of daily plan selection compared with non-adaptive RT in cervical cancer. MATERIAL AND METHODS: Ten consecutive patients who received pelvic irradiation, planning CTs (full and empty bladder), weekly post-fraction CTs and pre-fraction CBCTs were included...
May 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28445274/clinical-analysis-of-cervical-intraepithelial-neoplasia-with-vaginal-intraepithelial-neoplasia
#2
Yue He, Qun Zhao, Yu-Ning Geng, Shu-Li Yang, Cheng-Hong Yin, Yu-Mei Wu
The purpose of this prospective cohort study is to evaluate the importance of screening and its diagnostic accuracy compared with the pathological diagnosis of cervical intraepithelial neoplasia (CIN) with vaginal intraepithelial neoplasia (VAIN).The prospective study enrolled 419 patients (pts) and was conducted between February 1, 2015 and January 31, 2016 at Beijing Obstetrics and Gynecology Hospital, Capital Medical University.All enrolled pts underwent multipoint biopsy of cervix and vaginal wall directed by colposcopy...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28443070/crystal-structure-of-glyceraldehyde-3-phosphate-dehydrogenase-from-the-gram-positive-bacterial-pathogen-a-vaginae-an-immunoevasive-factor-that-interacts-with-the-human-c5a-anaphylatoxin
#3
Javier Querol-García, Francisco J Fernández, Ana V Marin, Sara Gómez, Daniel Fullà, Cecilia Melchor-Tafur, Virginia Franco-Hidalgo, Sebastián Albertí, Jordi Juanhuix, Santiago Rodríguez de Córdoba, José R Regueiro, M Cristina Vega
The Gram-positive anaerobic human pathogenic bacterium Atopobium vaginae causes most diagnosed cases of bacterial vaginosis as well as opportunistic infections in immunocompromised patients. In addition to its well-established role in carbohydrate metabolism, D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from Streptococcus pyogenes and S. pneumoniae have been reported to act as extracellular virulence factors during streptococcal infections. Here, we report the crystal structure of GAPDH from A. vaginae (AvGAPDH) at 2...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28442799/study-of-pruritus-vulvae-in-geriatric-age-group-in-tertiary-hospital
#4
Jasleen Kaur, Jyotika Kalsy
BACKGROUND: According to the World Health Organization criteria, geriatric population is people above 60 years of age. In this phase of life, a woman has already gone through menopause and its associated emotional, physical, and hormonal changes. These changes are due to gradual loss of estrogen that comes with menopause which results in dramatic changes in the appearance of vulva and vagina. With age, skin of vulva becomes thin, loses elasticity, and moisture so that the patient starts feeling burning and itchy sensation...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28441249/epidemiology-of-second-primary-tumors-in-women-with-ovarian-cancer
#5
Tomi T Kanninen, Dimitrios Nasioudis, Giovanni Sisti, Kevin Holcomb, Mariarosaria Di Tommaso, Susan Khalil, Anar Gojayev, Steven S Witkin
OBJECTIVE: The last large study of second primary tumors (SPTs) in women with ovarian cancer was published in 1996, prior to major changes in the differential diagnosis and treatment. The present study reports on the incidence of SPTs in a contemporary cohort of patients with a diagnosis of ovarian cancer. METHODS: Ovarian cancer patients with a diagnosis of an ovarian malignancy between 1992 and 2012 were identified and characterized from 13 registries of the Surveillance, Epidemiology, and End Results database...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28440666/relationship-between-delivery-modes-and-genitourinary-syndrome-among-postmenopausal-women
#6
M Yaralizadeh, P Abedi, P Salehinejad
OBJECTIVES: Many postmenopausal women suffer from genitourinary syndrome of menopause (GSM) due to the lack of estrogen. This study aimed to evaluate the relationship between mode of delivery and GSM among postmenopausal women. METHODS: We performed a case-control study of women who had had either vaginal delivery or Cesarean section. Data were collected through a sociodemographic questionnaire and a check list for assessing signs and symptoms of GSM. Subjective symptoms of vaginal atrophy (dryness, dyspareunia, itching, burning and paleness), pH of the vagina and maturation index were assessed and recorded...
April 25, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28438170/immunolocalization-of-steroidogenic-enzymes-in-the-vaginal-mucous-of-galea-spixii-during-the-estrous-cycle
#7
Amilton Cesar Dos Santos, Alan James Conley, Moacir Franco de Oliveira, Gleidson Benevides Oliveira, Diego Carvalho Viana, Antônio Chaves de Assis Neto
BACKGROUND: The synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex with the redox partner NADPH-cytochrome P450 oxidoreductase (CPR) for activity. Previous studies have identified expression of steroidogenic enzymes in vaginal tissue, suggesting local sex steroid synthesis. The current studies investigate P450c17, P450aromatase and CPR expression in vaginal mucosa of Galea spixii (Spix cavy) by immuno-histochemical and western immunoblot analyses...
April 24, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28437239/tprevalence-of-hpv-in-adults-aged-18-69-united-states-2011-2014
#8
Geraldine McQuillan, Deanna Kruszon-Moran, Lauri E Markowitz, Elizabeth R Unger, Ryne Paulose-Ram
Data from the National Health and Nutrition Examination Survey ● During 2011-2014, prevalence of any oral human papillomavirus (HPV) for adults aged 18-69 was 7.3%; high-risk HPV was 4.0%. ● Overall, prevalence of any and high-risk oral HPV was lowest among non-Hispanic Asian adults; any oral HPV was highest among non-Hispanic black adults. ● Prevalence of any and high-risk oral HPV was higher in men than women except for high-risk HPV among Asian adults. ● During 2013-2014, prevalence of any and high-risk genital HPV for adults aged 18-59 was 45...
April 2017: NCHS Data Brief
https://www.readbyqxmd.com/read/28435139/the-role-of-lactic-acid-production-by-probiotic-lactobacillus-species-in-vaginal-health
#9
Gilda Tachedjian, Muriel Aldunate, Catronia S Bradshaw, Richard A Cone
Vaginal eubiosis is characterised by beneficial lactobacillus-dominated microbiota. In contrast, vaginal dysbiosis (e.g. bacterial vaginosis, BV), characterised by an overgrowth of multiple anaerobes, is associated with an increased risk of adverse urogenital and reproductive health outcomes. A major distinguishing feature between the vaginal environment in states of eubiosis and dysbiosis is a high concentration of lactic acid, produced by lactobacilli, that acidifies the vagina in eubiosis versus a sharp drop in lactic acid and an increase in pH in dysbiosis...
April 20, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28434752/effects-of-intrauterine-infusion-of-escherichia-coli-lipopolysaccharide-on-uterine-health-resolution-of-purulent-vaginal-discharge-and-reproductive-performance-of-lactating-dairy-cows
#10
João G N Moraes, Paula R B Silva, Luís G D Mendonça, Alexandre A Scanavez, Joseane C C Silva, Ricardo C Chebel
The objectives of the current experiment were to evaluate the effects of intrauterine infusion of Escherichia coli lipopolysaccharide (LPS) in cows diagnosed with purulent vaginal discharge (PVD) on intrauterine cell population, resolution of PVD, uterine health, and reproductive performance. Jersey cows (n = 3,084) were examined using the Metricheck device to diagnose PVD at 35 ± 6 d postpartum. Purulent vaginal discharge was defined as the presence of purulent (≥50% pus) discharge detectable in the vagina...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28434104/mullerian-dysgenesis-a-critical-review-of-the-literature
#11
REVIEW
Souzana Choussein, Dimitrios Nasioudis, Dimitrios Schizas, Konstantinos P Economopoulos
PURPOSE: To present an update of the genetic, clinical, diagnostic, and therapeutic aspects of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. METHODS: Studies were considered eligible if they have evaluated patients with MRKH syndrome. Eligible articles were identified by a search of MEDLINE bibliographical database from 1950 to August 2016. A purely descriptive approach was adopted concerning all outcomes examined by the individual studies. RESULTS: MRKH syndrome is defined as congenital aplasia of the upper vagina and impairment of uterine development in normal 46XX females...
April 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28427752/spontaneously-arising-tumours-and-tumour-like-lesions-of-the-cervix-and-uterus-in-83-pet-guinea-pigs-cavia-porcellus
#12
C Laik-Schandelmaier, R Klopfleisch, S Schöniger, G Weiffenbach, M Staudacher, H Aupperle
Tumours and tumour-like lesions are rare findings in the genital system of guinea pigs. The aim of the present study was to characterize nodular lesions in the cervix and uterus of guinea pigs submitted for histopathological diagnosis. Samples from 83 pet animals were investigated. Cases included 64 surgically excised masses including complete uteri (n = 37), parts from uteri containing masses (n = 8), complete masses (n = 12) or samples from masses (n = 7) and 19 complete necropsy examinations. In 55 of the cases, only solitary changes were observed; in 28 cases two or more lesions were diagnosed...
April 17, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28426717/adjusting-cryodiluent-composition-for-improved-post-thaw-quality-of-rabbit-spermatozoa
#13
Sally E Hall, Cameron Negus, Danielle Johinke, Roslyn Bathgate
Improved fertility following artificial insemination with frozen-thawed spermatozoa would offer rabbit producers faster genetic improvement. Previous work investigating cryoprotectants for rabbit spermatozoa have reported inconsistent results. Semen was collected from three rabbit bucks by artificial vagina and frozen using a standard procedure with varied cryodiluent components. Post-thaw analysis encompassed motility, sperm kinematic parameters and acrosome and membrane integrity. Spermatozoa were evaluated at 0, 2 and 4 h after thawing...
2017: PloS One
https://www.readbyqxmd.com/read/28422418/factors-associated-with-mucosal-dryness-in-multiple-regions-and-skin-a-web-based-study-in-women
#14
Kayoko Ito, Kiyoshi Takamatsu, Kaname Nohno, Aki Sugano, Saori Funayama, Kouji Katsura, Noboru Kaneko, Mariko Ogawa, Jukka H Meurman, Makoto Inoue
AIM: We hypothesized that feeling mucosal dryness in one body region and the skin may be associated with dryness in other regions and that there are common background factors for dryness. In an earlier web-based survey, we reported prevalence figures of dry eyes, nose, mouth, skin, and vagina. In the present study, additional analyses were made to investigate the factors associated with dryness in each region, and simultaneous dryness in multiple regions. METHODS: A web-based questionnaire was completed by 310 Japanese women...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28422385/genital-bleeding-hemostasis-in-gynecologic-neoplasm-with-balloon-tamponade-new-treatment-option
#15
Noriko Karakida, Shintaro Yanazume, Marie Mori, Natsuko Uchida, Akio Tokudome, Hiroaki Kobayashi
Genital bleeding is the most common and serious complication in gynecologic malignancy. Different techniques are available for the control of severe bleeding, but standard treatment strategies have not been determined. Herein we report on the successful use of the balloon technique in two cases of genital bleeding in uterine neoplasm. The first case was of advanced cervical cancer with massive genital bleeding during radiotherapy. A metreurynter (mini-metro) was inserted into the vagina and hemostasis was indirectly achieved in the vaginal hematoma...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28422365/successful-vaginal-delivery-at-term-after-vaginal-reconstruction-with-labium-minus-flaps-in-a-patient-with-vaginal-atresia-a-rare-case-report
#16
Yu Liu, Yi-Feng Wang
We report a case of successful vaginal delivery after vaginal reconstruction with labium minus flaps in a 23-year-old patient with congenital vaginal atresia. The patient primarily presented with amenorrhea and cyclic abdominal pain; transabdominal ultrasonography revealed an enlarged uterus due to hematometra and absence of the lower segment of the vagina. Eight years ago, she had undergone an unsuccessful attempt at canalization at a local hospital. Upon referral to our hospital, she underwent vaginal reconstruction with labium minus flaps...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28421058/antimicrobial-compounds-produced-by-vaginal-lactobacillus-crispatus-are-able-to-strongly-inhibit-candida-albicans-growth-hyphal-formation-and-regulate-virulence-related-gene-expressions
#17
Shuai Wang, Qiangyi Wang, Ence Yang, Ling Yan, Tong Li, Hui Zhuang
The female vaginal environment contains diverse microorganisms, and their interactions play significant roles in health and disease. Lactobacillus species are the predominant vaginal microorganisms in healthy women and relevant as a barrier to defense against pathogens, including Candida albicans. The yeast-to-hyphae transition is believed to be a determinant of C. albicans pathogenesis. In this study, we investigated the effects of vaginal isolates of L. crispatus (seven strains), L. gasseri (six strains), and L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28420276/the-influence-of-maternal-vaginal-flora-on-the-intestinal-colonization-in-newborns-and-3-month-old-infants
#18
Iwona Gabriel, Anita Olejek, Krystyna Stencel-Gabriel, Miroslaw Wielgoś
The role of maternal vaginal bacteria on the colonization of neonatal gut is still matter of discussion. Our aim was estimate the role of maternal vaginal flora on the development of intestinal flora in neonates and 3- months-old infants. 79 maternal-neonatal pairs were included in the study. Vaginal swabs were taken before the rupture of membranes after admission to the delivery ward. First neonatal stool (meconium) and stool at 3-months-old infants were collected and cultured. All samples were subject to a microbiological analysis for Streptococcus, Staphylococcus, Bifidobacterium, Clostridium (including Cl...
April 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28420227/efficacy-and-tolerability-of-a-plant-based-multi-component-cream-ginetrox%C3%A2-in-vulvovaginal-disorders-of-the-genitourinary-syndrome-during-menopause
#19
Roberto Marrai, Giovanni Lissi, Stefano Togni, Giada Maramaldi, Marco Barbara, Luca Giacomelli
BACKGROUND: Genitourinary syndrome of menopause (GSM) is a symptomatic condition including vaginal dryness, irritation, dyspareunia and recurrent urinary tract infections which affects 40-54% of post-menopausal women. Although several estrogen-based therapies are available, it is generally preferable to avoid hormonal therapy, particularly in women with mild symptoms or at risk for estrogen-responsive neoplasia. Therefore, the most common treatment options are over-the-counter vaginal creams for symptomatic relief...
June 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28419509/automatic-diagnosis-of-vulvovaginal-candidiasis-from-pap-smear-images
#20
M Momenzadeh, M Sehhati, A Mehri Dehnavi, A Talebi, H Rabbani
Vulvovaginal candidiasis (VVC) is the most common genital infections that are seen every day in clinics. This infection is due to excessive growth of Candida that are normally present in the vagina in small numbers. Diagnosis of VVC is routinely done by direct microscopy of Pap smear samples and searching for the Candida in the Pap smear glass slides. This manual method is subjective, time consuming, labour-intensive and tedious. This study presents a computer-aided diagnostic (CAD) method to improve human diagnosis of VVC...
April 17, 2017: Journal of Microscopy
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