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Mir-124 and cardiomyocytes

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https://www.readbyqxmd.com/read/28849090/overexpressed-microrna-506-and-microrna-124-alleviate-h2o2-induced-human-cardiomyocyte-dysfunction-by-targeting-kr%C3%A3-ppel-like-factor-4-5
#1
Xiuzhou Zhang, Fuyan Liu, Qingqing Wang, Yuxue Geng
Krüppel-like factors (KLFs) regulate a wide variety of cellular functions and modulate pathological processes. In the present study, a post‑translational mechanism of microRNAs (miRs) was investigated in H2O2-induced human cardiomyocyte (HCM) injury. In H2O2‑cultured HCM cells, reactive oxygen species and apoptotic cells were measured via flow cytometry. miR‑506/‑124 mimics and inhibitors were transfected to induce gain or loss of miR‑506/‑124 function. Cell proliferation was analyzed by an MTT assay...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28478799/role-of-microrna-124-in-cardiomyocyte-hypertrophy-inducedby-angiotensin-ii
#2
Q Bao, L Chen, J Li, M Zhao, S Wu, W Wu, X Liu
Cardiac hypertrophy is a crucial predictor of heart failure and is regulated by microRNAs. MicroRNA-124 (miR-124) is regarded as a prognostic indicator for outcomes after cardiac arrest. However, whether miR-124 participates in cardiac hypertrophy remains unclear. Therefore, our study aimed to determine the role of miR-124 in angiotensin II(AngII)-induced myocardial hypertrophy and the possible mechanism. Primary cultured rat neonatal cardiomyocytes(NCMs) were transfected with miR-124 mimics or inhibitor, followed by AngII stimulation...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/22696253/microrna-124-regulates-cardiomyocyte-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-via-targeting-stat3-signaling
#3
Benzhi Cai, Jianping Li, Jinghao Wang, Xiaobin Luo, Jing Ai, Yanju Liu, Ning Wang, Haihai Liang, Mingyu Zhang, Nan Chen, Gang Wang, Shu Xing, Xin Zhou, Baofeng Yang, Xinyue Wang, Yanjie Lu
Accumulating evidence demonstrated that bone marrow-derived mesenchymal stem cells (BMSCs) may transdifferentiate into cardiomyocytes and replace apoptotic myocardium so as to improve functions of damaged hearts. However, little information is known about molecular mechanisms underlying myogenic conversion of BMSCs. microRNAs as endogenous noncoding small molecules function to inhibit protein translation post-transcriptionally by binding to complementary sequences of targeted mRNAs. Here, we reported that miR-124 was remarkably downregulated during cardiomyocyte differentiation of BMSCs induced by coculture with cardiomyocytes...
August 2012: Stem Cells
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