keyword
https://read.qxmd.com/read/28277742/mir-185-p2y6-axis-inhibits-angiotensin-ii-induced-human-aortic-vascular-smooth-muscle-cell-proliferation
#21
JOURNAL ARTICLE
Shunmin Wang, Lujun Tang, Qian Zhou, Duomei Lu, Wulei Duan, Cheng Chen, Lu Huang, Yuansheng Tan
The abnormal proliferation and apoptosis of human aortic vascular smooth muscle cells (HAVSMCs) play an important role in the pathogenesis of hypertension. Recent study revealed that angiotensin II (Ang II) could elicit HAVSMC dysfunction, to induce or aggravate hypertension. Purinergic receptor P2Y6, an inflammation-inducible G protein-coupled receptor, promoted Ang II-induced hypertension. In the present study, we revealed that Ang II induced HAVSMC proliferation and upregulated P2Y6 protein levels. After knockdown of P2Y6, the promotive effect of Ang II on HAVSMC proliferation was restored...
May 2017: DNA and Cell Biology
https://read.qxmd.com/read/28090150/m1-and-m2-functional-imprinting-of-primary-microglia-role-of-p2x7-activation-and-mir-125b
#22
REVIEW
Chiara Parisi, Giulia Napoli, Pablo Pelegrin, Cinzia Volonté
Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3-5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty genes associated with familial forms of ALS have provided insights into the mechanisms leading to motor neuron death. Moreover, mutations in two RNA binding proteins, TAR DNA binding protein 43 and fused in sarcoma, have raised the intriguing possibility that perturbations of RNA metabolism, including that of the small endogenous RNA molecules that repress target genes at the posttranscriptional level, that is, microRNAs, may contribute to disease pathogenesis...
2016: Mediators of Inflammation
https://read.qxmd.com/read/27840225/a-calcium-sensitive-feed-forward-loop-regulating-the-expression-of-the-atp-gated-purinergic-p2x7-receptor-via-specificity-protein-1-and-microrna-22
#23
JOURNAL ARTICLE
Tobias Engel, Gary P Brennan, Amaya Sanz-Rodriguez, Mariana Alves, Edward Beamer, Orla Watters, David C Henshall, Eva M Jimenez-Mateos
Cells have developed complex transcriptional regulatory mechanisms to maintain intracellular homeostasis and withstand pathophysiological stressors. Feed-forward loops comprising transcription factors that drive expression of both target gene and a microRNA as negative regulator, are gaining increasing recognition as key regulatory elements of cellular homeostasis. The ATP-gated purinergic P2X7 receptor (P2X7R) is an important driver of inflammation and has been implicated in the pathogenesis of numerous brain diseases including epilepsy...
February 2017: Biochimica et Biophysica Acta. Molecular Cell Research
https://read.qxmd.com/read/27623176/micrornas-modulate-the-purinergic-signaling-network
#24
REVIEW
Davide Ferrari, Nicoletta Bianchi, Holger K Eltzschig, Roberto Gambari
MicroRNAs (miRNAs) are small non-coding RNA molecules capable of silencing mRNA targets. miRNA dysregulation has been linked to cancer development, cardiovascular and neurological diseases, lipid metabolism, and impaired immunity. Therefore, miRNAs are gaining interest as putative novel disease biomarkers and therapeutic targets. Recent studies have shown that purinergic surface receptors activated by extracellular nucleotides (ATP, ADP, UTP, UDP), and by nucleosides such as adenosine (ADO), are subject to miRNA regulation...
October 2016: Trends in Molecular Medicine
https://read.qxmd.com/read/27412702/lentiviral-delivery-of-mir-133b-improves-functional-recovery-after-spinal-cord-injury-in-mice
#25
JOURNAL ARTICLE
Thomas Theis, Myung Yoo, Christopher S Park, Jian Chen, Sebastian Kügler, Kurt M Gibbs, Melitta Schachner
Based on the observation that microRNA (miRNA) 133b enhances regeneration after spinal cord injury in the adult zebrafish, we investigated whether this miRNA would be beneficial in a mammalian system in vitro and in vivo. We found that infection of cultured neurons with miR-133b promotes neurite outgrowth in vitro on an inhibitory substrate consisting of mixed chondroitin sulfate proteoglycans, when compared to infection with green fluorescent protein (GFP) for control. In vivo, viral infection of the injured adult mouse spinal cord at the time of injury at and in the vicinity of the lesion site enhanced expression of miR-133b...
August 2017: Molecular Neurobiology
https://read.qxmd.com/read/27391069/p2x7-targeting-inhibits-growth-of-human-mesothelioma
#26
JOURNAL ARTICLE
Francesca Amoroso, Erica Salaro, Simonetta Falzoni, Paola Chiozzi, Anna Lisa Giuliani, Giorgio Cavallesco, Pio Maniscalco, Andrea Puozzo, Ilaria Bononi, Fernanda Martini, Mauro Tognon, Francesco Di Virgilio
Malignant pleural mesothelioma (MPM) is an aggressive tumor refractory to anti-blastic therapy. MPM cells show several genetic and biochemical defects, e.g. overexpression of oncogenes, downregulation of onco-suppressor genes, dysregulation of microRNA, or alteration of intracellular Ca2+ homeostasis and of apoptosis. No information is as yet available on purinergic signalling in this tumor. Signalling via the P2X7 (P2RX7 or P2X7R) purinergic receptor is attracting increasing attention as a pathway involved in cancer cell death or proliferation...
August 2, 2016: Oncotarget
https://read.qxmd.com/read/26794445/microrna-125b-regulates-microglia-activation-and-motor-neuron-death-in-als
#27
JOURNAL ARTICLE
C Parisi, G Napoli, S Amadio, A Spalloni, S Apolloni, P Longone, C Volonté
Understanding the means by which microglia self-regulate the neuroinflammatory response helps modulating their reaction during neurodegeneration. In amyotrophic lateral sclerosis (ALS), classical NF-κB pathway is related to persistent microglia activation and motor neuron injury; however, mechanisms of negative control of NF-κB activity remain unexplored. One of the major players in the termination of classical NF-κB pathway is the ubiquitin-editing enzyme A20, which has recognized anti-inflammatory functions...
March 2016: Cell Death and Differentiation
https://read.qxmd.com/read/26221610/the-emerging-role-of-mir-223-in-platelet-reactivity-implications-in-antiplatelet-therapy
#28
REVIEW
Rui Shi, Xin Zhou, Wen-Jie Ji, Ying-Ying Zhang, Yong-Qiang Ma, Jian-Qi Zhang, Yu-Ming Li
Platelets are anuclear cells and are devoid of genomic DNA, but they are capable of de novo protein synthesis from mRNA derived from their progenitor cells, megakaryocytes. There is mounting evidence that microRNA (miRNA) plays an important role in regulating gene expression in platelets. miR-223 is the most abundant miRNAs in megakaryocytes and platelets. One of the miR-223-regulated genes is ADP P2Y12, a key target for current antiplatelet drug therapy. Recent studies showed that a blunted response to P2Y12 antagonist, that is, high on-treatment platelet reactivity (HTPR), is a strong predictor of major cardiovascular events (MACEs) in coronary heart disease (CHD) patients receiving antiplatelet treatment...
2015: BioMed Research International
https://read.qxmd.com/read/26088024/extracellular-uridine-triphosphate-and-adenosine-triphosphate-attenuate-endothelial-inflammation-through-mir-22-mediated-icam-1-inhibition
#29
JOURNAL ARTICLE
Olof Gidlöf, Ramasri Sathanoori, Marco Magistri, Mohammad Ali Faghihi, Claes Wahlestedt, Björn Olde, David Erlinge
Adenosine and uridine triphosphate (ATP and UTP) can act as extracellular signalling molecules, playing important roles in vascular biology and disease. ATP and UTP acting via the P2Y2-receptor have, for example, been shown to regulate endothelial dilatation, inflammation and angiogenesis. MicroRNAs (miRNAs), a class of regulatory, short, non-coding RNAs, have been shown to be important regulators of these biological processes. In this study, we used RNA deep-sequencing to explore changes in miRNA expression in the human microvascular endothelial cell line HMEC-1 upon UTP treatment...
2015: Journal of Vascular Research
https://read.qxmd.com/read/26072940/microrna-155-microtuning-the-allergic-concert
#30
EDITORIAL
F Cortinas-Elizondo, S von Gunten
No abstract text is available yet for this article.
September 2015: Allergy
https://read.qxmd.com/read/25972159/microrna-155-deficient-dendritic-cells-cause-less-severe-gvhd-through-reduced-migration-and-defective-inflammasome-activation
#31
JOURNAL ARTICLE
Sophia Chen, Benjamin A H Smith, Joseena Iype, Alessandro Prestipino, Dietmar Pfeifer, Sebastian Grundmann, Annette Schmitt-Graeff, Marco Idzko, Yvonne Beck, Gabriele Prinz, Jürgen Finke, Justus Duyster, Robert Zeiser
The successful treatment of acute leukemias with allogeneic hematopoietic cell transplantation (allo-HCT) is limited by acute graft-versus-host disease (GVHD). Because microRNA-155 (miR-155) regulates activation of the innate immune system, we aimed to determine its function in dendritic cells (DCs) during GVHD in an experimental model. We observed that miR-155 deficiency of the recipient led to improved survival, reduced serum levels of proinflammatory cytokines, and lower GVHD histopathology scores. In addition, miR-155(-/-) bone marrow chimeric mice receiving allo-HCT and miR-155(-/-) DCs showed that miR-155 deficiency in the DC compartment was responsible for protection from GVHD...
July 2, 2015: Blood
https://read.qxmd.com/read/25944053/microrna-155-modulates-p2r-signaling-and-th2-priming-of-dendritic-cells-during-allergic-airway-inflammation-in-mice
#32
JOURNAL ARTICLE
A Zech, C K Ayata, F Pankratz, A Meyer, K Baudiß, S Cicko, G G Yegutkin, S Grundmann, M Idzko
BACKGROUND: Dendritic cells (DCs) are the professional antigen-presenting cells (APCs) in the lung. They are known to be key players in the induction and maintenance of allergic asthma by cross-linking innate and adaptive immune responses. MicroRNAs (miRNAs) are known to influence cell fate and function by translational suppression or induction of messenger RNA (mRNA) degradation. miR-155 has been shown to be a crucial regulator of the immune system. However, its function in the pathogenesis of allergic airway inflammation (AAI) is not completely elucidated yet...
September 2015: Allergy
https://read.qxmd.com/read/25824147/microrna-150-protects-the-mouse-heart-from-ischaemic-injury-by-regulating-cell-death
#33
JOURNAL ARTICLE
Yaoping Tang, Yongchao Wang, Kyoung-Mi Park, Qiuping Hu, Jian-Peng Teoh, Zuzana Broskova, Punithavathi Ranganathan, Calpurnia Jayakumar, Jie Li, Huabo Su, Yaoliang Tang, Ganesan Ramesh, Il-Man Kim
AIMS: Cardiac injury is accompanied by dynamic changes in the expression of microRNAs (miRs). For example, miR-150 is down-regulated in patients with acute myocardial infarction, atrial fibrillation, dilated and ischaemic cardiomyopathy as well as in various mouse heart failure (HF) models. Circulating miR-150 has been recently proposed as a better biomarker of HF than traditional clinical markers such as brain natriuretic peptide. We recently showed using the β-arrestin-biased β-blocker, carvedilol that β-arrestin1-biased β1-adrenergic receptor cardioprotective signalling stimulates the processing of miR-150 in the heart...
June 1, 2015: Cardiovascular Research
https://read.qxmd.com/read/25668431/sick-sinus-syndrome-and-atrial-fibrillation-in-older-persons-a-view-from-the-sinoatrial-nodal-myocyte
#34
REVIEW
O Monfredi, M R Boyett
Sick sinus syndrome remains a highly relevant clinical entity, being responsible for the implantation of the majority of electronic pacemakers worldwide. It is an infinitely more complex disease than it was believed when first described in the mid part of the 20th century. It not only involves the innate leading pacemaker region of the heart, the sinoatrial node, but also the atrial myocardium, predisposing to atrial tachydysrhythmias. It remains controversial as to whether the dysfunction of the sinoatrial node directly causes the dysfunction of the atrial myocardium, or vice versa, or indeed whether these two aspects of the condition arise through some related underlying pathological mechanism, such as extracellular matrix remodeling, i...
June 2015: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/25078617/regulation-of-the-p2x7r-by-microrna-216b-in-human-breast-cancer
#35
JOURNAL ARTICLE
Luming Zheng, Xukui Zhang, Feng Yang, Jian Zhu, Peng Zhou, Fang Yu, Lei Hou, Lei Xiao, Qingqing He, Baocheng Wang
Breast cancer is the most common cancer in women around the world. However, the molecular mechanisms underlying breast cancer pathogenesis are only partially understood. Here, in this study, we found that P2X7R was up-regulated and miR-216b was down-regulated in breast cancer cell lines and tissues. Using bioinformatic analysis and 3'UTR luciferase reporter assay, we determined P2X7R can be directly targeted by miR-216b, which can down-regulate endogenous P2X7R mRNA and protein levels. Ectopic expression of miR-216b mimics leads to inhibited cell growth and apoptosis, while blocking expression of the miR-216b results in increased cell proliferation...
September 12, 2014: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/24909125/editorial-overview-musculoskeletal-are-we-on-the-road-to-personalised-medicine-in-musculoskeletal-diseases
#36
EDITORIAL
Alison Gartland, Lynne J Hocking
No abstract text is available yet for this article.
June 2014: Current Opinion in Pharmacology
https://read.qxmd.com/read/24780820/mir-34a-expands-myeloid-derived-suppressor-cells-via-apoptosis-inhibition
#37
JOURNAL ARTICLE
Anfei Huang, Haitao Zhang, Si Chen, Fei Xia, Yi Yang, Fulu Dong, Di Sun, Sidong Xiong, Jinping Zhang
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population and show significant expansion under pathological conditions. microRNA plays important roles in many biological processes, whether microRNAs have a function in the expansion of MDSCs is still not very clear. In this study, miR-34a overexpression can induce the expansion of MDSCs in bone marrow chimera and transgenic mice model. The experimental results suggest that miR-34a inhibited the apoptosis of MDSCs but did not affect the proliferation of MDSCs...
August 15, 2014: Experimental Cell Research
https://read.qxmd.com/read/24336079/dysregulated-micrornas-in-amyotrophic-lateral-sclerosis-microglia-modulate-genes-linked-to-neuroinflammation
#38
JOURNAL ARTICLE
C Parisi, I Arisi, N D'Ambrosi, A E Storti, R Brandi, M D'Onofrio, C Volonté
MicroRNAs (miRNAs) regulate gene expression at post-transcriptional level and are key modulators of immune system, whose dysfunction contributes to the progression of neuroinflammatory diseaseas such as amyotrophic lateral sclerosis (ALS), the most widespread motor neuron disorder. ALS is a non-cell-autonomous disease targeting motor neurons and neighboring glia, with microgliosis directly contributing to neurodegeneration. As limited information exists on miRNAs dysregulations in ALS, we examined this topic in primary microglia from superoxide dismutase 1-G93A mouse model...
December 12, 2013: Cell Death & Disease
https://read.qxmd.com/read/24316888/identification-of-a-unique-tgf-%C3%AE-dependent-molecular-and-functional-signature-in-microglia
#39
JOURNAL ARTICLE
Oleg Butovsky, Mark P Jedrychowski, Craig S Moore, Ron Cialic, Amanda J Lanser, Galina Gabriely, Thomas Koeglsperger, Ben Dake, Pauline M Wu, Camille E Doykan, Zain Fanek, Liping Liu, Zhuoxun Chen, Jeffrey D Rothstein, Richard M Ransohoff, Steven P Gygi, Jack P Antel, Howard L Weiner
Microglia are myeloid cells of the CNS that participate both in normal CNS function and in disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that were uniquely or highly expressed in microglia versus myeloid and other immune cells. Of the 239 genes, 106 were enriched in microglia as compared with astrocytes, oligodendrocytes and neurons. This microglia signature was not observed in microglial lines or in monocytes recruited to the CNS, and was also observed in human microglia...
January 2014: Nature Neuroscience
https://read.qxmd.com/read/24312495/mir-150-promotes-human-breast-cancer-growth-and-malignant-behavior-by-targeting-the-pro-apoptotic-purinergic-p2x7-receptor
#40
JOURNAL ARTICLE
Songyin Huang, Yongsong Chen, Wei Wu, Nengyong Ouyang, Jianing Chen, Hongyu Li, Xiaoqiang Liu, Fengxi Su, Ling Lin, Yandan Yao
The P2X7 receptor regulates cell growth through mediation of apoptosis. Low level expression of P2X7 has been linked to cancer development because tumor cells harboring a defective P2X7 mechanism can escape P2X7 pro-apoptotic control. microRNAs (miRNAs) function as negative regulators of post-transcriptional gene expression, playing major roles in cellular differentiation, proliferation, and metastasis. In this study, we found that miR-150 was over-expressed in breast cancer cell lines and tissues. In these breast cancer cell lines, blocking the action of miR-150 with inhibitors leads to cell death, while ectopic expression of the miR-150 results in increased cell proliferation...
2013: PloS One
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