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https://www.readbyqxmd.com/read/30110717/dose-intensified-bendamustine-and-melphalan-benmel-conditioning-before-second-autologous-transplantation-in-myeloma-patients
#1
Sarah Farag, Barbara Jeker, Ulrike Bacher, Behrouz Mansouri Taleghani, Beatrice U Mueller, Urban Novak, Thomas Pabst
Consolidation in myeloma patients with high-dose melphalan chemotherapy (Mel HDCT) and autologous transplantation (ASCT) is standard of care since more than two decades. However, definite cure remains exceptional despite intensive treatment, and improving effectiveness of HDCT remains an unmet clinical need. Combining intensified bendamustine with melphalan may represent an option. We analyzed safety and efficacy of combining dose-intensified bendamustine (200 mg/m2 on days -4/-3) with high-dose melphalan (100 mg/m2 on days -2/-1) before a 2nd (tandem) ASCT in adverse risk myeloma patients after Mel HDCT/ASCT1...
August 15, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/30110677/kidney-protection-effect-of-ginsenoside-re-and-its-underlying-mechanisms-on-cisplatin-induced-kidney-injury
#2
Zi Wang, Yan-Fei Li, Xin-Yue Han, Yin-Shi Sun, Lian-Xue Zhang, Wei Liu, Xiang-Xiang Liu, Wei Li, Ying-Ying Liu
BACKGROUND/AIMS: Cisplatin (CDDP) was the first platinum-containing anti-cancer drug. However, CDDP causes nephrotoxicity as a side effect, which limits its clinic application. The aim of this study was to investigate the renoprotective effect of ginsenoside Re (G-Re) in a murine model of CDDP-induced acute kidney injury. METHODS: Male ICR mice were divided into 4 groups. G-Re was administered to the mice by oral gavage once a day at a dose of 25 mg/kg for 10 days...
August 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30107838/cidp-myasthenia-gravis-and-membranous-glomerulonephritis-three-autoimmune-disorders-in-one-patient-a-case-report
#3
Saskia Bolz, Andreas Totzeck, Kerstin Amann, Mark Stettner, Christoph Kleinschnitz, Tim Hagenacker
BACKGROUND: We present a patient fulfilling the electrophysiological criteria for definite chronic inflammatory demyelinating polyneuropathy (CIDP), antibody-positive myasthenia gravis (MG), and membranous glomerulonephritis (MGN) confirmed by biopsy. To our knowledge, this is the first case of the concomitant appearance of these three autoimmune diseases in a single patient. CASE REPRESENTATION: A 42-year-old Caucasian male presented with rapidly progressive gait disturbance, distal weakness of the lower extremities, ascending hypoesthesia, impaired fine motor skills, and beginning cranial nerve palsy showing dysarthrophonia, facial paralysis, and eye movement abnormalities and was diagnosed as rapid onset (atypical) CIDP...
August 14, 2018: BMC Neurology
https://www.readbyqxmd.com/read/30107703/-the-application-of-intestinal-stomas-in-mesenteric-ischemia
#4
S L Sun, W W Ding, B C Liu, X X Fan, X J Wu, J S Li
Objective: To evaluate the application of intestinal stomas in mesenteric ischemia (MI) according to the concept of damage control surgery. Methods: Clinical data of 59 MI patients received intestinal stomas at Jinling Hospital, Nanjing University School of Medicine from January 2010 to June 2017 were analyzed retrospectively. There were 41 male and 18 female patients aging of (51±14) years (ranging from 20 to 86 years). All the patients were divided to two groups according to the degree of bowel ischemia: acute MI group (AMI, bowel necrosis, n =43) and chronic MI group (CMI, bowel stricture, n =16)...
August 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/30105595/slc2a9-glut9-mediates-urate-reabsorption-in-the-mouse-kidney
#5
Muriel Auberson, Sophie Stadelmann, Candice Stoudmann, Klaus Seuwen, Robert Koesters, Bernard Thorens, Olivier Bonny
Uric acid (UA) is a metabolite of purine degradation and is involved in gout flairs and kidney stones formation. GLUT9 (SLC2A9) was previously shown to be a urate transporter in vitro. In vivo, humans carrying GLUT9 loss-of-function mutations have familial renal hypouricemia type 2, a condition characterized by hypouricemia, UA renal wasting associated with kidney stones, and an increased propensity to acute renal failure during strenuous exercise. Mice carrying a deletion of GLUT9 in the whole body are hyperuricemic and display a severe nephropathy due to intratubular uric acid precipitation...
August 13, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30104322/induced-pluripotent-stem-cell-derived-podocyte-like-cells-as-models-for-assessing-mechanisms-underlying-heritable-disease-phenotype-initial-studies-using-two-alport-syndrome-patient-lines-indicate-impaired-potassium-channel-activity
#6
John M Haynes, James N Selby, Isaiah Pl Abad, Teresa Vandekolk, Joan K Ho, Wai-Ling Lieuw, Katie Leach, Judith Savige, Sheetal Saini, Craig Fisher, Sharon Ricardo
Renal podocyte survival depends upon the dynamic regulation of a complex cell architecture that links glomerular basement membrane to integrins, ion channels and receptors. Alport syndrome is a heritable chronic kidney disease where mutations in α3, α4 or α5 collagen genes promote podocyte death. In rodent models of renal failure, activation of the calcium sensing receptor (CaSR) can protect podocytes from stress related death. In this study we assess CaSR function in podocyte-like cells from induced-pluripotent stem cells derived from two patients with Alport Syndrome (AS1 & AS2), a renal disease free individual (NHMC) and an immortalized podocyte-like (HIP) cell line...
August 13, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/30104297/new-onset-diabetes-after-acute-kidney-injury-requiring-dialysis
#7
Yu-Feng Lin, Shuei-Liong Lin, Tao-Min Huang, Shao-Yu Yang, Tai-Shuan Lai, Likwang Chen, Vin-Cent Wu, Tzong-Shinn Chu, Kwan-Dun Wu
OBJECTIVE: Acute kidney injury (AKI) is related to a high prevalence of insulin resistance. However, information is lacking on the sequelae of further metabolic change among AKI requiring dialysis in patients who could be weaned off dialysis (acute kidney disease [AKD]). RESEARCH DESIGN AND METHODS: Using the National Health Insurance Research Database from 2000 to 2010, with the exclusion of those with diabetes at the start, we identified 3,307 subjects with AKD and 9,921 matched control subjects from 963,037 hospitalized patients for the comparison of the outcomes, including new-onset diabetes and all-cause mortality...
August 13, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30104042/72-year-old-woman-with-fatigue-confusion-and-severe-acute-renal-failure
#8
Xin Zhang, Aditya S Pawar, Eddie L Greene
No abstract text is available yet for this article.
August 10, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/30102484/hemolytic-uremic-syndrome-and-iga-nephropathy-in-a-child-coincidence-or-not
#9
Serra Sürmeli-Döven, Ali Delibaş, İclal Gürses, Uğur Raşit Kayacan, Banu Coşkun-Yılmaz, Kaan Esen, Emine Korkmaz, Fatih Özaltın
Sürmeli-Döven S, Delibaş A, Gürses İ, Kayacan UR, Coşkun-Yılmaz B, Esen K, Korkmaz E, Özaltın F. Hemolytic uremic syndrome and IgA nephropathy in a child: Coincidence or not? Turk J Pediatr 2018; 60: 81-85. A previously healthy 18-month old boy, presenting with diarrhea, anemia, thrombocytopenia and acute renal failure was admitted to our hospital. Hemolytic uremic syndrome (HUS) was diagnosed with his clinical and laboratory findings. His stool was negative for Shiga toxin producing E. coli (STEC)...
2018: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/30100769/epidemiology-prognostic-factors-and-outcome-of-trauma-patients-admitted-in-a-brazilian-intensive-care-unit
#10
Gabriella F Pogorzelski, Taline Aal Silva, Thamara Piazza, Tomás M Lacerda, Fernando Ac Spencer Netto, Amaury Cesar Jorge, Péricles Ad Duarte
Background: Trauma is a major cause of hospital admissions and is associated with manifold complications and high mortality rates. However, data on intensive care unit (ICU) admissions are scarce in developing and low-income countries, where its incidence has been increasing. Objectives: To analyze epidemiological and clinical factors and outcomes in adult trauma patients admitted to the ICU of a public teaching hospital in a developing country as well as to identify risk factors for complications in the ICU...
2018: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/30098967/a-bayesian-model-to-predict-survival-after-left-ventricular-assist-device-implantation
#11
Manreet K Kanwar, Lisa C Lohmueller, Robert L Kormos, Jeffrey J Teuteberg, Joseph G Rogers, JoAnn Lindenfeld, Stephen H Bailey, Colleen K McIlvennan, Raymond Benza, Srinivas Murali, James Antaki
OBJECTIVES: This study investigates the use of a Bayesian statistical models to predict survival at various time points in patients undergoing left ventricular assist device (LVAD) implantation. BACKGROUND: LVADs are being increasingly used in patients with end-stage heart failure. Appropriate patient selection continues to be key in optimizing post-LVAD outcomes. METHODS: Data used for this study were derived from 10,277 adult patients from the INTERMACS (Inter-Agency Registry for Mechanically Assisted Circulatory Support) who had a primary LVAD implanted between January 2012 and December 2015...
August 7, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/30098962/randomized-evaluation-of-heart-failure-with-preserved-ejection-fraction-patients-with-acute-heart-failure-and-dopamine-the-ropa-dop-trial
#12
Kavita Sharma, Joban Vaishnav, Rohan Kalathiya, Jiun-Ruey Hu, John Miller, Nishant Shah, Terence Hill, Michelle Sharp, Allison Tsao, Kevin M Alexander, Richa Gupta, Kristina Montemayor, Lara Kovell, Jessica E Chasler, Yizhen J Lee, Derek M Fine, David A Kass, Robert G Weiss, David R Thiemann, Chiadi E Ndumele, Steven P Schulman, Stuart D Russell
OBJECTIVES: This study sought to compare a continuous infusion diuretic strategy versus an intermittent bolus diuretic strategy, with the addition of low-dose dopamine (3 μg/kg/min) in the treatment of hospitalized patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND: HFpEF patients are susceptible to development of worsening renal function (WRF) when hospitalized with acute heart failure; however, inpatient treatment strategies to achieve safe and effective diuresis in HFpEF patients have not been studied to date...
August 7, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/30098762/the-short-term-prognostic-value-of-c-reactive-protein-in-elderly-patients-with-acute-heart-failure
#13
D Chivite, J Franco, F Formiga, P Salamanca-Bautista, L Manzano, A Conde-Martel, J C Arévalo-Lorido, I Suárez-Pedreira, J Casado-Cerrada, M Montero-Pérez-Barquero
INTRODUCTION AND OBJECTIVES: Plasma c-reactive protein (crp) has been tested as a prognostic marker in acute heart failure (ahf). Whether its measurement really provides significant prognostic information when applied to elderly patients with ahf episodes remains unclear. METHODS: We measured the plasma crp values of patients admitted because of any type of ahf to internal medicine services. We evaluated the association of these values with the patients' baseline clinical characteristics and their 3-month posdischarge all-cause mortality or readmission rates...
August 8, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/30098285/the-diagnostic-challenge-of-ovarian-carcinoma-in-normal-sized-ovaries-a-report-of-two-cases
#14
Soon Leong Yong, Safilah Dahian, Aznim Hani Ramlan, Marcus Kang
Normal-sized ovarian carcinoma syndrome (NOCS) is a rare condition characterised by malignancy identified in ovaries of normal size with abdominal metastasis. We report two cases of advanced ovarian carcinoma with ovaries of normal size. The first case was a 13-year-old adolescent with malignant ascites and bilateral normal sized multicystic ovaries detected on ultrasound. Serum cancer antigen 125 (CA 125) and lactate dehydrogenase were markedly raised. A computed tomography (CT) scan showed the presence of thick omental cake but no ovarian tumour...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30096767/mechanisms-of-lps-induced-acute-kidney-injury-in-neonatal-and-adult-rats
#15
Egor Y Plotnikov, Anna A Brezgunova, Irina B Pevzner, Ljubava D Zorova, Vasily N Manskikh, Vasily A Popkov, Denis N Silachev, Dmitry B Zorov
Neonatal sepsis is one of the major causes of mortality and morbidity in newborns, greatly associated with severe acute kidney injury (AKI) and failure. Handling of newborns with kidney damage can be significantly different compared to adults, and it is necessary to consider the individuality of an organism's response to systemic inflammation. In this study, we used lipopolysaccharide (LPS)-mediated acute kidney injury model to study mechanisms of kidney cells damage in neonatal and adult rats. We found LPS-associated oxidative stress was more severe in adults compared to neonates, as judged by levels of carbonylated proteins and products of lipids peroxidation...
August 8, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/30095800/can-elective-spine-surgery-be-performed-safely-among-nonagenarians-analysis-of-a-national-inpatient-database-in-japan
#16
Takeshi Oichi, Yasushi Oshima, Hiroki Matsui, Kiyohide Fushimi, Sakae Tanaka, Hideo Yasunaga
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To compare morbidity and mortality between nonagenarians and other older adult patients who underwent elective spine surgery. SUMMARY OF BACKGROUND DATA: There is a lack of information of the perioperative risks of nonagenarians undergoing spine surgery. METHODS: Data of patients aged ≥65 years who underwent elective spine surgery from July 2010 to March 2013 were extracted from the Diagnosis Procedure Combination database, a nationwide administrative inpatient database in Japan...
August 7, 2018: Spine
https://www.readbyqxmd.com/read/30094785/successful-treatment-of-diabetic-ketoacidosis-and-hyperglycemic-hyperosmolar-status-in-an-infant-with-kcnj11-related-neonatal-diabetes-mellitus-via-continuous-renal-replacement-therapy
#17
Ting Chen, Dandan Zhang, Zhenjiang Bai, Shuiyan Wu, Haiying Wu, Rongrong Xie, Ying Li, Fengyun Wang, Xiuli Chen, Hui Sun, Xiaoyan Wang, Linqi Chen
Neonatal diabetes mellitus (NDM) is a rare monogenic disorder presenting as uncontrolled hyperglycemia during the first 6 months of life. Hyperglycemic hyperosmolar state (HHS) is quite rare in NDM patients, and reported experience with this condition is limited. Continuous renal replacement therapy (CRRT) is frequently used as a mode of dialytic treatment in critically ill patients with acute renal failure, but has seldom been used in patients with diabetic ketoacidosis (DKA) and HHS. We report the case of a 2-month-old infant admitted to our hospital presenting with dyspnea and lethargy...
August 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30094023/hyponatremia-in-kidney-transplant-patients-its-pathophysiologic-mechanisms
#18
Carlos G Musso, Alejandrina Castañeda, María Giordani, Cesar Mombelli, Silvia Groppa, Nora Imperiali, Guillermo Rosa Diez
Kidney transplant patients (KTPs), and particularly those with advanced chronic kidney rejection, may be affected by opportunistic infections, metabolic alterations and vascular and oncologic diseases that promote clinical conditions that require a variety of treatments, the combinations of which may predispose them to hyponatremia. Salt and water imbalance can induce abnormalities in volemia and/or serum sodium depending on the nature of this alteration (increase or decrease), its absolute magnitude (mild or severe) and its relative magnitude (body sodium:water ratio)...
August 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/30093137/effect-of-sacubitril-valsartan-on-cardiac-filling-pressures-in-patients-with-left-ventricular-systolic-dysfunction
#19
Zubair Khan, Gunjan Gholkar, Sunit Tolia, Herman Kado, Marcel Zughaib
BACKGROUND: Sacubitril/valsartan is the newest neurohormonal agent approved for therapy in patients with heart failure with reduced ejection fraction (HFrEF). Little is known about its acute and incremental hemodynamic effects. We aimed to evaluate the change in hemodynamic profiles measured using an implanted monitoring device in HFrEF patients initiated on sacubitril/valsartan therapy. METHODS: We prospectively enrolled 13 subjects with HFrEF and pre-implanted CardioMEMS™ device on maximally tolerated guideline-directed medical therapy and no contraindications to sacubitril/valsartan therapy...
August 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30092952/left-main-revascularization-with-pci-or-cabg-in-patients-with-chronic-kidney-disease-excel-trial
#20
Gennaro Giustino, Roxana Mehran, Patrick W Serruys, Joseph F Sabik, Milan Milojevic, Charles A Simonton, John D Puskas, David E Kandzari, Marie-Claude Morice, David P Taggart, Anthony H Gershlick, Philippe Généreux, Zixuan Zhang, Thomas McAndrew, Björn Redfors, Michael Ragosta, Irving L Kron, Ovidiu Dressler, Martin B Leon, Stuart J Pocock, Ori Ben-Yehuda, Arie Pieter Kappetein, Gregg W Stone
BACKGROUND: The optimal revascularization strategy for patients with left main coronary artery disease (LMCAD) and chronic kidney disease (CKD) remains unclear. OBJECTIVES: This study investigated the comparative effectiveness of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery in patients with LMCAD and low or intermediate anatomical complexity according to baseline renal function from the multicenter randomized EXCEL (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial...
August 14, 2018: Journal of the American College of Cardiology
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