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https://www.readbyqxmd.com/read/30553740/incidence-cost-and-risk-factors-for-readmission-after-coronary-artery-bypass-grafting
#1
Rohan M Shah, Qianzi Zhang, Subhasis Chatterjee, Faisal Cheema, Gabriel Loor, Scott A Lemaire, Matthew J Wall, Joseph S Coselli, Todd K Rosengart, Ravi K Ghanta
BACKGROUND: Readmissions adversely affect hospital reimbursement and quality measures. We aimed to evaluate the incidence, cost, and risk factors for readmission following Coronary Artery Bypass Grafting (CABG). METHODS: We queried the National Readmissions Database (NRD) and isolated patients who underwent CABG from 2013-2014. We determined the top reasons for readmission and compared demographics, comorbidities, in-hospital outcomes, and costs between readmitted and non-readmitted patients...
December 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30553739/impact-of-complications-on-resource-utilization-during-90-day-cabg-bundle-for-medicare-beneficiaries
#2
Steven D Culler, Phillip P Brown, Aaron D Kugelmass, David J Cohen, Matthew R Reynolds, Marc R Katz, Michael L Schlosser, April W Simon
BACKGROUND: The study reports the impact of adverse events during the index CABG surgery on Medicare reimbursement for the index hospitalization and a 90-day follow-up period. METHODS: This retrospective study used 2014 Medicare claims files for hospitals, skilled nursing services, rehabilitation facilities, long-term care facilities, home health services and outpatient visits. The study sample is 37,106 Medicare beneficiaries that survived an index CABG in a US hospital during the first three quarters of 2014...
December 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30552270/survival-and-new-onset-morbidity-after-critical-care-admission-for-acute-pancreatitis-in-scotland-a-national-electronic-healthcare-record-linkage-cohort-study
#3
Chiara Ventre, Sian Nowell, Catriona Graham, Doug Kidd, Christos Skouras, Damian J Mole
INTRODUCTION: Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival. OBJECTIVE: To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP. DESIGN: Cohort study. SETTING: Electronic healthcare registries in Scotland. PARTICIPANTS: The ccAP cohort included 1471 patients admitted to critical care with AP between 1 January 2008 and 31 December 2010 followed up until 31 December 2014...
December 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/30551039/decreased-risk-of-renal-impairment-in-atrial-fibrillation-patients-receiving-non-vitamin-k-antagonist-oral-anticoagulants-a-pooled-analysis-of-randomized-controlled-trials-and-real-world-studies
#4
REVIEW
Chi Zhang, Zhi-Chun Gu, Zheng Ding, Long Shen, Mang-Mang Pan, Ying-Li Zheng, Hou-Wen Lin, Jun Pu
BACKGROUND: Patients with warfarin have a potential risk of warfarin-related nephropathy, which could result in the discontinuation of anticoagulation therapy. The question of whether non-vitamin K antagonist oral anticoagulants (NOACs) use is associated with increased risk of renal impairment in atrial fibrillation (AF) patients remains unanswered. METHODS: Studies were systematically searched through Medline, Embase, Cochrane Library databases, and ClinicalTrials...
December 6, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30548094/simultaneous-liver-kidney-transplantation
#5
REVIEW
Ashwani K Singal, Song Ong, Sanjaya Satpathy, Patrick S Kamath, Russel H Wiesner
Kidney injury is frequently seen in patients with end stage liver disease from cirrhosis and liver failure. Among select patients, simultaneous liver kidney (SLK) transplantation provides improved post-transplant graft and patient outcomes compared to liver transplantation alone. We conducted review of the existing literature on SLK transplant criteria and outcomes. Since the introduction of the model for end-stage disease score in 2002, there has been an increased use of simultaneous liver kidney transplantation...
December 10, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30543420/design-and-synthesis-of-potent-long-acting-lipidated-relaxin-2-analogs
#6
Avinash Muppidi, Sang Jun Lee, Che-Hsiung Hsu, Huafei Zou, Candy Lee, Elsa Pflimlin, Madhupriya Mahankali, Pengyu Yang, Elizabeth Chao, Insha Ahmad, Andreas Crameri, Danling Wang, Ashley Woods, Weijun Shen
Peptide hormone relaxin-2, a member of the insulin family of peptides, plays a key role in hemodynamics and renal function and has shown preclinical efficacy in multiple disease models, including acute heart failure, fibrosis, preeclampsia, and corneal wound healing. Recently, serelaxin, a recombinant version of relaxin-2, has been studied in a large phase 3 clinical trial (RELAX-AHF-2) for acute decompensated heart failure patients with disappointing outcome. The poor in vivo half-life of relaxin-2 may have limited its therapeutic efficacy and long-term cardiovascular benefit...
December 13, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/30542527/immunosuppression-associated-posterior-reversible-encephalopathy-syndrome-in-an-acute-leukemia-case
#7
Umit Y Malkan, Gursel Gunes, Haluk Demiroglu, Hakan Goker
Posterior reversible encephalopathy syndrome (PRES) was described in 1996. Herein, we aimed to report an immunosuppression- related PRES case. A 34-year-old woman was diagnosed as t-cell acute lymphoblastic leukemia and allogeneic hematopoietic stem cell transplantation (HSCT) was performed. Cyclosporine was given for GVHD prophylaxis in addition to the other routine medications of HSCT. She was hospitalized for acute renal failure and due to the possible contribution of acute renal failure cyclosporine was stopped...
November 6, 2018: Hematology Reports
https://www.readbyqxmd.com/read/30540645/combination-of-st2-and-b-type-natriuretic-peptide-in-diabetic-patients-with-acute-heart-failure-relation-with-ventricular-stiffness-and-outcome
#8
Gaetano Ruocco, Isabella Evangelista, Beatrice Franci, Barbara Lucani, Simona Martini, Ranuccio Nuti, Alberto Palazzuoli
BACKGROUND: Diabetes is a common disease in heart failure and its prevalence ranges from 10 to 30%. ST-2 is a novel biomarker of myocardial fibrosis and remodelling in heart failure and may be involved in the inflammatory process of diabetes mellitus. In this study, we sought: to evaluate levels of ST-2 and B-type natriuretic peptide (BNP) in groups with acute heart failure with and without diabetes; to analyse the prognostic impact of ST-2 over a 6-month follow-up period. METHODS: We performed an echocardiographic examination and measured ST-2 and BNP within 24 h of hospital admission...
December 11, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/30538886/stereotactic-body-radiotherapy-used-as-a-bridge-to-liver-transplant-in-patients-with-hepatocellular-carcinoma-and-child-pugh-score-%C3%A2-8-cirrhosis
#9
Steven Gresswell, Rachel Tobillo, Shaakir Hasan, Tadahiro Uemura, Lorenzo Machado, Ngoc Thai, Alexander Kirichenko
Introduction: To report on SBRT as a bridge to OLT for patients with HCC and Child-Pugh ≥8 cirrhosis. Methods: Retrospective review of 15 patients, treated from 2010-2017. Three patients excluded secondary to delisting from prohibitive substance. Twelve patients (17 lesions) included for final analysis. Hepatic SPECT functional treatment planning utilized. Results: The median age of 60 years with a median CP 9 and MELD 14. The median SBRT dose was 40 Gy in 5 fractions, and median tumor size was 2...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/30538873/successfully-treated-norovirus-and-sapovirus-associated-diarrhea-in-three-renal-transplant-patients
#10
Noha Ghusson, Gustavo Vasquez
Objectives: To examine the burden of norovirus- and sapovirus-related diarrhea in renal transplant patients and to propose the use of nitazoxanide as a therapeutic option for treatment. Methods: We reviewed three renal transplant patients with viral diarrhea requiring hospitalization due to acute renal failure and signs of graft rejection. All three patients were treated with nitazoxanide. We examined their clinical courses after therapy and compared time to resolution of symptoms and viral shedding...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/30538643/preventing-peritoneal-dialysis-associated-fibrosis-by-therapeutic-blunting-of-peritoneal-toll-like-receptor-activity
#11
REVIEW
Anne-Catherine Raby, Mario O Labéta
Peritoneal dialysis (PD) is an essential daily life-saving treatment for end-stage renal failure. PD therapy is limited by peritoneal inflammation, which leads to peritoneal membrane failure as a result of progressive fibrosis. Peritoneal infections, with the concomitant acute inflammatory response and membrane fibrosis development, worsen PD patient outcomes. Patients who remain infection-free, however, also show evidence of inflammation-induced membrane damage and fibrosis, leading to PD cessation. In this case, uraemia, prolonged exposure to bio-incompatible PD solutions and surgical catheter insertion have been reported to induce sterile peritoneal inflammation and fibrosis as a result of cellular stress or tissue injury...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30537724/renal-functions-and-prognosis-stratification-in-chronic-heart-failure-patients-and-the-importance-of-neutrophil-gelatinase-associated-lipocalin
#12
Karel Lábr, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Monika Špinarová, Ondřej Ludka, Jiří Jarkovský, Klára Benešová, Monika Goldbergová-Pávková, Růžena Lábrová
BACKGROUND/AIMS: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients...
December 7, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30536705/living-donor-liver-transplantation-for-acute-on-chronic-liver-failure
#13
Sanjay Kumar Yadav, Neeraj Saraf, Narendra S Choudhary, Jayant Kumar Saha, Sujeet Kumar Saha, Amit Rastogi, Prashanth Bhangui, Arvinder Singh Soin
INTRODUCTION: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of previously diagnosed or undiagnosed liver disease with organ failure(s) with high short-term mortality. This study was conducted to report the outcomes of LDLT in ACLF and assess the survival benefit of liver transplantation in these patients. MATERIALS AND METHODS: It was a retrospective study of 218 ACLF patients (based on EASL-CLIF criteria) from January 2014 through November 2017...
December 8, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/30536423/perspective-into-the-regulation-of-cell-generated-forces-toward-stem-cell-migration-and-differentiation
#14
Liujing Chen, Tu Huang, Yini Qiao, Fulin Jiang, Jingxiang Lan, Yimei Zhou, Cai Yang, Shanyu Yan, Kaihui Luo, Liping Su, Juan Li
Stem cells are promising candidates for cell-based therapies in diverse conditions including regenerating damaged tissues, treating inflammation in virtue of sepsis, acute renal failure, and cardiovascular disease. Advancement of these therapies relies on the ability to guide stem cells to migrate directly and differentiate towards specific cell phenotypes. During the past decade, many researchers have demonstrated that exogenous applied forces could significantly affect the migration and lineage differentiation of stem cells...
December 9, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30535929/impact-of-hemoperfusion-with-polymyxin-b-added-to-hemofiltration-in-patients-with-endotoxic-shock-a-case-control-study
#15
Ana Navas, Ricard Ferrer, Maria Luisa Martínez, Gemma Gomà, Gisela Gili, Jordi Masip, David Suárez, Antonio Artigas
BACKGROUND: Septic shock is a leading cause of death in critical patients. In patients with gram-negative septic shock, hemoperfusion with polymyxin B aims to remove endotoxins from plasma. We analyzed the clinical and biological response to hemoperfusion in patients with septic shock and acute kidney injury. METHODS: This prospective case-control study in the medical-surgical intensive care unit of a university hospital included consecutive adults patients with septic shock and suspected gram-negative bacteria infection with elevated plasma endotoxin activity (EAA > 0...
December 7, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/30535516/early-extubation-followed-by-immediate-noninvasive-ventilation-vs-standard-extubation-in-hypoxemic-patients-a-randomized-clinical-trial
#16
Rosanna Vaschetto, Federico Longhini, Paolo Persona, Carlo Ori, Giulia Stefani, Songqiao Liu, Yang Yi, Weihua Lu, Tao Yu, Xiaoming Luo, Rui Tang, Maoqin Li, Jiaqiong Li, Gianmaria Cammarota, Andrea Bruni, Eugenio Garofalo, Zhaochen Jin, Jun Yan, Ruiqiang Zheng, Jingjing Yin, Stefania Guido, Francesco Della Corte, Tiziano Fontana, Cesare Gregoretti, Andrea Cortegiani, Antonino Giarratano, Claudia Montagnini, Silvio Cavuto, Haibo Qiu, Paolo Navalesi
PURPOSE: Noninvasive ventilation (NIV) may facilitate withdrawal of invasive mechanical ventilation (i-MV) and shorten intensive care unit (ICU) length of stay (LOS) in hypercapnic patients, while data are lacking on hypoxemic patients. We aim to determine whether NIV after early extubation reduces the duration of i-MV and ICU LOS in patients recovering from hypoxemic acute respiratory failure. METHODS: Highly selected non-hypercapnic hypoxemic patients were randomly assigned to receive NIV after early or standard extubation...
December 10, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/30534896/-acute-pulmonary-fibrosis-associated-with-paraquat-poisoning-report-of-one-case
#17
Sebastián Cartagena, Israel Díaz, Constanza Gutiérrez, Jorge Dreyse, Matías Florenzano, Marcela Palavecino, Tomás Regueira
Paraquat, a non-selective bipyridyl pesticide, is one of the leading causes of death from intoxication in many parts of Asia and America. It is the second most sold herbicide worldwide, being widely used in Chile. Its ingestion generates toxicity due to the release of superoxide radicals, mainly affecting kidneys, lungs and liver. There is no antidote available. We report a 31 years old male who ingested Paraquat for suicidal purposes. He developed an acute renal and hepatic failure and a rapidly progressive severe respiratory failure with images compatible with acute pulmonary fibrosis...
July 2018: Revista Médica de Chile
https://www.readbyqxmd.com/read/30531780/-results-of-a-single-centre-study-of-open-and-endovascular-operations-of-prosthetic-repair-of-abdominal-aortic-aneurysms
#18
E D Zvereva, B B Komakha, D A Zverev, M A Chernyavsky, M L Gordeev
OBJECTIVE: The purpose of the study was to assess surgical outcomes in patients suffering from an infrarenal abdominal aortic aneurysm and treated at the Department of Cardiovascular Surgery #2 of the National Medical Research Centre named after V.A. Almazov. PATIENTS AND METHODS: We carried out a non-randomized retrospective study including a total of 209 patients presenting with an infrarenal abdominal aortic aneurysm. Of these, 160 (76%) patients were subjected to open surgical interventions (Group One) and 49 (24%) patients underwent endovascular isolation of the abdominal aortic aneurysm (Group Two)...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/30531211/a-fatal-case-of-acute-renal-failure-from-envenoming-syndrome-after-massive-bee-attack-a-case-report-and-literature-review
#19
Rhome L Hughes
Envenoming syndrome is a systemic toxic reaction to the inoculation of large volume of insect venom, typically after a swarm attack from bees. Africanized honey bees are notorious for their aggressive nature, and human deaths resulting from Africanized honey bee attacks are consistently reported. Whereas anaphylaxis is the most common lethal mechanism of injury, delayed deaths can also occur as a consequence of severe venom toxicity with resultant end organ damage. Acute renal failure complicating massive envenomation is a rare but potentially fatal outcome after Africanized honey bee attack and may be heralded by laboratory evidence of rhabdomyolysis...
December 6, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/30531208/symptomatic-hiv-infected-patients-have-poorer-outcomes-following-emergency-general-surgery-a-study-of-the-nationwide-inpatient-sample
#20
Britt J Sandler, Kimberly A Davis, Kevin M Schuster
BACKGROUND: The impact of HIV infection on outcomes following common emergency general surgery procedures has not been evaluated since the widespread introduction of highly-active antiretroviral therapy (HAART). METHODS: A retrospective cohort study was conducted using the Nationwide Inpatient Sample. Records of patients who underwent laparoscopic or open appendectomy, cholecystectomy, or colon resection after emergency admission from 2004-2011 were obtained. Outcomes analyzed included in-hospital mortality, length of stay, total charges, and selected postoperative complications...
December 5, 2018: Journal of Trauma and Acute Care Surgery
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