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https://www.readbyqxmd.com/read/30120245/cell-penetrating-artificial-mitochondria-targeting-peptide-conjugated-metallothionein-1a-alleviates-mitochondrial-damage-in-parkinson-s-disease-models
#1
Young Cheol Kang, Minuk Son, Sora Kang, Suyeol Im, Ying Piao, Kwang Suk Lim, Min-Young Song, Kang-Sik Park, Yong-Hee Kim, Youngmi Kim Pak
An excess of reactive oxygen species (ROS) relative to the antioxidant capacity causes oxidative stress, which plays a role in the development of Parkinson's disease (PD). Because mitochondria are both sites of ROS generation and targets of ROS damage, the delivery of antioxidants to mitochondria might prevent or alleviate PD. To transduce the antioxidant protein human metallothionein 1A (hMT1A) into mitochondria, we computationally designed a cell-penetrating artificial mitochondria-targeting peptide (CAMP)...
August 17, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/30120165/permanent-chemotherapy-induced-alopecia-in-patients-with-breast-cancer-a-3-year-prospective-cohort-study
#2
Danbee Kang, Im-Ryung Kim, Eun-Kyung Choi, Young Hyuck Im, Yeon Hee Park, Jin Seok Ahn, Jeong Eon Lee, Seok Jin Nam, Hae Kwang Lee, Ji-Hye Park, Dong-Youn Lee, Mario E Lacouture, Eliseo Guallar, Juhee Cho
BACKGROUND: Although chemotherapy-induced alopecia (CIA) is considered temporary, some patients report persistent alopecia several years after chemotherapy. There is, however, a paucity of long-term prospective data on the incidence and impact of permanent CIA (PCIA). The objective of our study was to estimate the long-term incidence of PCIA in a cohort of patients with breast cancer whose hair volume and density were measured prior to chemotherapy and who were followed for 3 years after chemotherapy...
August 17, 2018: Oncologist
https://www.readbyqxmd.com/read/30120085/a-mobile-app-whiteteeth-to-promote-good-oral-health-behavior-among-dutch-adolescents-with-fixed-orthodontic-appliances-intervention-mapping-approach
#3
Janneke Francisca Maria Scheerman, Pepijn van Empelen, Cor van Loveren, Berno van Meijel
BACKGROUND: The insertion of fixed orthodontic appliances increases the risk of dental caries, particularly in adolescents. Caries can be prevented through good oral health behavior. To support adolescents with fixed orthodontic appliances and for promoting oral health behavior, we developed a theory- and evidence-based mHealth program, the WhiteTeeth app. OBJECTIVE: The objective of our paper was to describe the systematic development and content of the WhiteTeeth app...
August 17, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/30119576/zadoff-chu-sequence-based-upstream-ranging-in-ofdma-pon-mobile-radio-access-networks
#4
Ahmed Galib Reza, Geun Young Kim, Myoung-Soo Lee, June-Koo Kevin Rhee
Orthogonal frequency division multiple access (OFDMA) uplink in a passive optical network (PON) requires the delay alignment for OFDMA symbols from remotely distributed optical network units (ONUs). In this paper, we experimentally demonstrate and analyze the performance of a Zadoff-Chu (ZC) sequence-based upstream ranging scheme in an intensity modulation/direct detection (IM/DD)-based OFDMA-PON. The experimental results show that the proposed scheme can achieve upstream synchronization with only marginal inter-carrier interference (ICI) and requires no additional bandwidths in a typical OFDMA transmission with cyclic prefix (CP)...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30119450/high-fidelity-distributed-fiber-optic-acoustic-sensor-with-fading-noise-suppressed-and-sub-meter-spatial-resolution
#5
Dian Chen, Qingwen Liu, Zuyuan He
In order to solve fading problem and realize sub-meter spatial resolution in DAS, this paper proposes a novel configuration of time-gated digital optical frequency domain reflectometry (TGD-OFDR) based on optical intensity modulator (IM). IM has a large modulation bandwidth and the positive and negative harmonics can be fully used to suppress fading while the spatial resolution remains unchanged. In experiments, with fading suppressed, the spatial resolution of DAS is 0.8 m and the strain resolution is about 245...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30118637/trends-in-prehospital-analgesia-administration-by-us-forces-from-2007-through-2016
#6
Steven G Schauer, Jason F Naylor, Joseph K Maddry, Carmen Hinojosa-Laborde, Michael D April
BACKGROUND: Tactical Combat Casualty Care (TCCC) guidelines regarding prehospital analgesia agents have evolved. The guidelines stopped recommending intramuscular (IM) morphine in 1996, recommending only intravenous (IV) routes. In 2006, the guidelines recommended oral transmucosal fentanyl citrate (OTFC), and in 2012 it added ketamine via all routes. It remains unclear to what extent prehospital analgesia administered on the battlefield adheres to these guidelines. We seek to describe trends in analgesia administration patterns on the battlefield during 2007-2016...
August 17, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/30118596/improved-sensitivity-and-separations-for-phosphopeptides-using-online-lc-coupled-with-structures-for-lossless-ion-manipulations-slim-im-ms
#7
Christopher D Chouinard, Gabe Nagy, Ian K Webb, Tujin Shi, Erin Shammel Baker, Spencer A Prost, Tao Liu, Yehia M Ibrahim, Richard D Smith
Phosphoproteomics greatly augments proteomics and holds tremendous potential for insights into the modulation of biological systems for various disease states, etc. However, numerous challenges hinder conventional methods in terms of measurement sensitivity, throughput, quantification, and capabilities for confident phosphopeptide and phosphosite identification. In this work, we report the first example of integrating structures for lossless ion manipulations ion mobility-mass spectrometry (SLIM IM-MS) with online reversed-phase liquid chromatography (LC) to evaluate its potential for addressing the aforementioned challenges...
August 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30118538/research-article-educational-and-psychological-aspects-diagnosis-of-gestational-diabetes-a-teachable-moment
#8
J Okely, C Mason, A Collier, N Dunnachie, V Swanson
AIMS: Research regarding the determinants of concordance with gestational diabetes mellitus (GDM) treatment is limited. Here, we test whether the psychosocial changes outlined in the teachable moments model, as proposed by McBride et al. (McBride CM, Emmons KM, Lipkus IM. Understanding the potential of teachable moments: the case of smoking cessation. Health Educ Res 2003; 18: 156-170) are associated with following GDM treatment recommendations. METHODS: Fifty-nine women completed a baseline questionnaire (1 week after GDM diagnosis) in which they reported risk perception, social support, emotional response, the importance of their maternal identity and self-efficacy...
August 17, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30117699/lebensqualit%C3%A3-t-und-behandlungsziele-bei-psoriasis-aus-patientensicht-ergebnisse-eines-%C3%A3-sterreichweiten-querschnitt-survey
#9
Peter Wolf, Wolfgang Weger, Franz Legat, Clemens Painsi, Werner Saxinger, Robert Müllegger, Paul Sator, Gudrun Ratzinger, Sylvia Selhofer, Leo Richter, Wolfgang Salmhofer, Bernhard Lange-Asschenfeldt, Franz Trautinger, Alexander Mlynek, Robert Strohal, Matthias Augustin, Franz Quehenberger
HINTERGRUND: Patienten mit Psoriasis sind mit einer krankheitsbedingten Einschränkung ihrer Lebensqualität konfrontiert, weshalb einer hochqualitativen dermatologischen Versorgung ein besonderer Stellenwert zukommt. PATIENTEN UND METHODIK: Wir führten einen bundesweiten Querschnitt-Survey in Österreich (BQSAustria Psoriasis 2014/2015) mit dem Schwerpunkt auf Lebensqualität und Therapiezufriedenheit bei Patienten mit Psoriasis in dermatologischer Behandlung vorwiegend an Zentren mit überwiegend tertiären Versorgungsaufgaben durch...
August 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/30114835/theoretical-analysis-of-the-srs-induced-mode-distortion-in-large-mode-area-fiber-amplifiers
#10
Wei Liu, Pengfei Ma, Chen Shi, Pu Zhou, Zongfu Jiang
In this paper, the spectral evolution properties of different transverse modes with the stimulated Raman scattering (SRS) effect are analyzed in large-mode-area (LMA) fiber amplifiers for the first time. Both the ratios of laser power in Raman Stokes light and high order modes (HOMs) can be calculated through the comprehensive analysis of transverse mode competition and nonlinear transverse mode coupling processes. The theoretical study reveals that SRS-induced inter-modal wave mixing (IM-WM) effect would transfer power from signal light in LP01 mode to Raman Stokes light in LP11 mode and lead to the onset of the mode distortion phenomenon in high-power LMA fiber amplifiers...
June 11, 2018: Optics Express
https://www.readbyqxmd.com/read/30114808/experimental-study-of-performance-enhanced-im-dd-transmissions-based-on-constellation-switching
#11
Meng Xiang, Qunbi Zhuge, Zhenpin Xing, Kuo Zhang, Thang M Hoang, Fangyuan Zhang, David V Plant
In this work, we experimentally investigate the performance improvement in IM/DD systems using constellation switching (CS), which is simple to implement with a reasonably low complexity. By encoding extra bits on the selection of a PAM constellation pattern from a set of constellations, a lower symbol rate can be used to achieve the same system bit rate compared with standard PAM systems based on a single constellation pattern. In our experiments with bandwidth limited components, including a 14 GHz bandwidth digital-to-analog converter (DAC), we demonstrate that the CS signals can improve the receiver sensitivity...
June 11, 2018: Optics Express
https://www.readbyqxmd.com/read/30114801/inline-fiber-optic-power-sensor-featuring-a-variable-tap-ratio-based-on-a-tightly-focused-femtosecond-laser-inscription
#12
Peng Ji, Seon-U Baek, Chang-Hyun Park, Sang-Shin Lee, Young-Eun Im, Younghee Choi
We propose and demonstrate an inline fiber optic power sensor (IFPS) resorting to an embedded waveguide tap, which is formed to traverse across the cladding and core of a standard single-mode fiber. The tap was produced via a single-step inscription based on the femtosecond laser direct-writing method. A tightly focused pulsed laser beam has been particularly exploited to suppress the elongation along the laser propagation direction, thereby improving the cross-sectional symmetry of the created tap waveguide...
June 11, 2018: Optics Express
https://www.readbyqxmd.com/read/30114463/clinical-responses-in-cows-vaccinated-with-a-developed-prototype-killed-staphylococcus-aureus-mastitis-vaccine
#13
I U Hambali, K R Bhutto, F F A Jesse, A Lawan, M N Odhah, A H Wahid, M L Mohd Azmi, Z Zakaria, M Arsalan, N A Muhammad, M N Jefri
Mastitis is an inflammatory condition of the udder that occurs as a result of the release of leucocytes into the udder in a response to bacterial invasion. The major causes of mastitis are an array of gram positive and negative bacteria, however, algae, virus, fungi, mechanical or thermal injury to the gland have also been identified as possible causes. Mastitis vaccines are yet to be developed using Malaysian local isolate of bacteria. The objective of the present experimental trial was to develop a monovalent vaccine against mastitis using S...
August 13, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30114143/real-time-20-37-gb-s-optical-ofdm-receiver-for-pon-im-dd-systems
#14
Julián S Bruno, Vicenç Almenar, Javier Valls, Juan L Corral
This paper presents the hardware architecture of an OFDM receiver suitable for optical communications. The receiver has been implemented in an FPGA device and used to demonstrate experimentally an optical OFDM transmission in a passive optical link with a directly modulated DFB laser and DAC/ADC at 5 GS/s. A bit rate of 20.37 Gb/s is achieved using an OFDM signal with subcarrier modulation format up to 512-QAM, it has been successfully transmitted over 10 km SSMF with a spectral efficiency of 8.38 bit/s/Hz.
July 23, 2018: Optics Express
https://www.readbyqxmd.com/read/30113824/computational-optics-enables-breast-cancer-profiling-in-point-of-care-settings
#15
Jouha Min, Hyungsoon Im, Matthew Allen, Phillip J McFarland, Ismail Degani, Hojeong Yu, Erica Normandin, Divya Pathania, Jaymin Patel, Cesar M Castro, Ralph Weissleder, Hakho Lee
The global burden of cancer, severe diagnostic bottlenecks in underserved regions, and underfunded health care systems are fueling the need for inexpensive, rapid and treatment-informative diagnostics. Based on advances in computational optics and deep learning, we have developed a low-cost digital system, termed AIDA (artificial intelligence diffraction analysis), for breast cancer diagnosis of fine needle aspirates. Here, we show high accuracy (>90%) in (i) recognizing cells directly from diffraction patterns and (ii) classifying breast cancer types using deep-learning based analysis of sample aspirates...
August 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/30112754/unilateral-autologous-breast-reconstruction-with-bi-pedicled-conjoined-deep-inferior-epigastric-perforator-flaps
#16
Akhil K Seth, Pieter G L Koolen, Steven M Sultan, Bernard T Lee, Heather A Erhard, David T Greenspun
BACKGROUND:  The abdomen remains the most popular and reliable donor site for autologous breast reconstruction. Some patients, however, lack sufficient tissue to recreate an aesthetic breast mound using a single-pedicle, deep inferior epigastric perforator (DIEP) flap, particularly when matching a contralateral native breast. The amount of abdominal skin and/or soft tissue reliably supplied by one vascular pedicle is frequently insufficient to adequately restore the breast skin envelope and "footprint...
August 15, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/30112351/purification-and-characterization-of-monoclonal-igg-antibodies-recognizing-ebola-virus-glycoprotein
#17
Baek-Sang Han, Ho-Young Jang, Trina Racine, Xiangguo Qiu, Jeong-Im Sin
Purpose: The goal of this study was to purify and characterize Ebola virus glycoprotein (GP)-specific IgG antibodies from hybridoma clones. Materials and Methods: For hybridoma production, mice were injected by intramuscular-electroporation with GP DNA vaccines, and boosted with GP vaccines. The spleen cells were used for producing GP-specific hybridoma. Enzyme-linked immunosorbent assay, Western blot assay, flow cytometry, and virus-neutralizing assay were used to test the ability of monoclonal IgG antibodies to recognize GP and neutralize Ebola virus...
July 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/30111432/-diagnostic-value-of-combined-detection-of-hla-g-and-il-6-in-children-with-infectious-mononucleosis
#18
Shi-Yong Deng, Ming Chen, Xu-Dong Wang, Xia Guo, Kun Wu, Xia Zhang
OBJECTIVE: To investigate the diagnostic value of combined detection of HLA-G and IL-6 in children with infectious mononucleosis (IM). METHODS: Eighty-three children suffered from infectious mononucleosis hospitalized in Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital) from January 2014 to June 2017 were selected as the IM group, 83 healthy children in the same period were selected as the as control group. Enzyme-linked in munosorbent assay (ELISA) was used to detect and compare the changes of HLA-G and IL-6 levels between 2 groups...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30111314/malaria-control-and-chemoprophylaxis-policy-in-the-republic-of-korea-armed-forces-for-the-previous-20-years-1997-2016
#19
Jae Hyoung Im, Kyungmin Huh, Chang-Gyo Yoon, Hyeongtaek Woo, Jin-Soo Lee, Moon-Hyun Chung, Terry A Klein, Jaehun Jung
BACKGROUND: Vivax malaria reemerged along the Demilitarized Zone (DMZ), Republic of Korea (ROK), in 1993. While it was hypothesized that vivax malaria would spread throughout the peninsula, nearly all cases were due to exposure near the DMZ. To reduce spillover of vivax malaria to the civilian community, the ROK Ministry of National Defense (MND) initiated malaria prevention policies including a large-scale chemoprophylaxis programme in malaria high-risk areas in 1997. The present study investigated the overall changes in the incidence of malaria among ROK soldiers and the mass chemoprophylaxis program from 1997 to 2016...
August 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30111210/characteristics-prehospital-management-and-outcomes-in-patients-assessed-for-hypoglycemia-repeat-access-to-prehospital-or-emergency-care
#20
Julie E Sinclair, Mike Austin, Mark Froats, Shannon Leduc, Justin Maloney, Richard Dionne, Andy Reed, Christian Vaillancourt
BACKGROUND: In Ontario, Canada, there currently are no prehospital treat-and-release protocols and the safety of this practice remains unclear. We sought to describe the characteristics, management, and outcomes of patients with hypoglycemia treated by paramedics, and to determine the predictors of repeat access to prehospital or emergency department (ED) care within 72 hours of initial paramedic assessment. METHODS: We performed a health record review of paramedic call reports and ED records over a 12-month period...
August 15, 2018: Prehospital Emergency Care
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