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Jiawei Li, Alexander Begbie, Belinda J Boehm, Alexander Button, Charles Whidborne, Yannii Pouferis, David M Huang, Tara L Pukala
DNA and RNA triplexes are thought to play key roles in a range of cellular processes such as gene regulation and epigenetic remodeling and have been implicated in human disease such as Friedreich's ataxia. In this work, ion mobility-mass spectrometry (IM-MS) is used with supporting UV-visible spectroscopy to investigate DNA triplex assembly, considering stability and specificity, for GAA·TTC oligonucleotide sequences of relevance to Friedreich's ataxia. We demonstrate that, contrary to other examples, parallel triplex structures are favored for these sequences and that stability is enhanced by increasing oligonucleotide length and decreasing pH...
October 19, 2018: Journal of the American Society for Mass Spectrometry
Stanley Cohan, Kyle Smoot, Kiren Kresa-Reahl, Robert Garland, Wei-Shi Yeh, Ning Wu, Crystal Watson
INTRODUCTION: This study was designed to assess real-world outcomes of patients with multiple sclerosis (MS) who were stable on interferon (IFN) beta therapy in the year prior to switching to another IFN beta therapy versus those who continued on the initial treatment. METHODS: This study used administrative claims from MarketScan Commercial Claims and Encounters Database, from January 1, 2010, to March 31, 2015, to identify MS patients aged 18-64 years who remained relapse free for at least 1 year while continuously treated with an IFN beta therapy...
October 20, 2018: Advances in Therapy
Ravi Verma, Changhon Lee, Eun-Ji Jeun, Jaeu Yi, Kwang Soon Kim, Ambarnil Ghosh, Seohyun Byun, Choong-Gu Lee, Hye-Ji Kang, Gi-Cheon Kim, Chang-Duk Jun, Gwenaël Jan, Chang-Hee Suh, Ju-Yang Jung, Jonathan Sprent, Dipayan Rudra, Cristina De Castro, Antonio Molinaro, Charles D Surh, Sin-Hyeog Im
Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3+ T regulatory (Treg ) cells. Although mucosa-associated commensal microbiota has been implicated in Treg generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3+ Treg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B...
October 19, 2018: Science Immunology
Sangyeon Pak, Yuljae Cho, John Hong, Juwon Lee, Sanghyo Lee, Bo Hou, Geon-Hyoung An, Young-Woo Lee, Jae Eun Jang, Hyunsik Im, Stephen M Morris, Jung Inn Sohn, SeungNam Cha, Jong Min Kim
Phototransistors that are based on a hybrid vertical heterojunction structure of two-dimensional (2D)/quantum dots (QDs) have recently attracted attention as a promising device architecture for enhancing the quantum efficiency of photodetectors. However, to optimize the device structure to allow for more efficient charge separation and transfer to the electrodes, a better understanding of the photophysical mechanisms that take place in these architectures is required. Here, we employ a novel concept involving the modulation of the built-in potential within the QD layers for creating a new hybrid MoS2 /PbS QDs phototransistor with consecutive type II junctions...
October 19, 2018: ACS Applied Materials & Interfaces
Noeul Kang, Yeonseok Choi, Yunjoo Im, Junsu Choe, Jhingook Kim, Joungho Han, Tae Jeong Kim, Hojoong Kim
Thoracolithiasis is a rare benign condition with mobile free bodies in the pleural cavity. It is asymptomatic and mostly found incidentally. Up to our knowledge there is no report of symptomatic numerous thoracolithiasis. We report a very rare case of thoracolithiasis in a 36-year-old female with chest discomfort. Images from computed tomography presented a chain of small non-enhancing nodules in the left hemi-diaphragmatic pleura. Exploratory thoracoscopy was performed and twenty-five mobile pearl like thoracolithiasis were discovered...
2018: Respiratory Medicine Case Reports
Ling Li, Soo Jin Lee, Qiu Ping Yuan, Wan Taek Im, Sun Chang Kim, Nam Soo Han
Background: Ginsenoside Rg3(S) and compound K (C-K) are pharmacologically active components of ginseng that promote human health and improve quality of life. The aim of this study was to produce Rg3(S) and C-K from ginseng extract using recombinant Lactococcus lactis . Methods: L. lactis subsp. cremoris NZ9000 ( L. lactis NZ9000), which harbors β-glucosidase genes ( BglPm and BglBX10 ) from Paenibacillus mucilaginosus and Flavobacterium johnsoniae , respectively, was reacted with ginseng extract (protopanaxadiol-type ginsenoside mixture)...
October 2018: Journal of Ginseng Research
Yoo Jin Hong, Jin Hur, Kyunghwa Han, Dong Jin Im, Young Joo Suh, Hye-Jeong Lee, Young Jin Kim, Byoung Wook Choi
It is critical to distinguish between cardiac tumors and thrombi because they require different treatment strategies. Although accurate differentiation of these cardiac masses can be challenging, computed tomography (CT) and magnetic resonance imaging (MRI) are promising tools to improve their diagnosis. This study aimed to assess the diagnostic value of a volume-based quantification strategy using dual-energy CT to differentiate between cardiac tumors and thrombi. We prospectively enrolled 41 patients who had a cardiac mass...
October 18, 2018: Scientific Reports
Gilda Varricchi, Antonio Pecoraro, Ludovica Crescenzi, Giancarlo Marone, Antonio Travaglino, Francesco Paolo D'Armiento, Arturo Genovese, Giuseppe Spadaro
BACKGROUND: Common variable immunodeficiency (CVID) encompasses a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infections, autoimmunity and malignancies. Gastrointestinal manifestations are frequently associated with CVID. OBJECTIVE: In this cross-sectional study, we evaluated gastric and duodenal involvement in a cohort of adult patients with CVID. METHODS: Upper gastrointestinal endoscopy was performed in 58 patients (26 males, mean age 47...
October 10, 2018: Current Pharmaceutical Biotechnology
Mi-Jeong Yoon, Youngkook Kim, Geun Young Park, YoungJun Jang, Sun Im
No abstract text is available yet for this article.
October 16, 2018: American Journal of Physical Medicine & Rehabilitation
Clara E Hill, Sarah Knox, Kristen G Pinto-Coelho
We review definitions and provide case examples of therapist self-disclosure (TSD) and immediacy (Im). We then present a qualitative meta-analysis of 21 studies that examined the subsequent process following TSD and Im in psychotherapy (excluding analogue and correlational studies). Across the 21 studies, the most frequent subsequent processes were enhanced therapy relationship, improved client mental health functioning, gains in insight, and overall helpfulness, suggesting that most often TSD and Im were followed by positive and beneficial therapeutic processes...
December 2018: Psychotherapy
Lena Pinzur, Levent Akyuez, Lilia Levdansky, Michal Blumenfeld, Evgenia Volinsky, Zami Aberman, Petra Reinke, Racheli Ofir, Hans-Dieter Volk, Raphael Gorodetsky
BACKGROUND: Most current cell-based regenerative therapies are based on the indirect induction of the affected tissues repair. Xenogeneic cell-based treatment with expanded human placenta stromal cells, predominantly from fetal origin (PLX-RAD cells), were shown to mitigate significantly acute radiation syndrome (ARS) following high dose irradiation in mice, with expedited regain of weight loss and haematopoietic function. The current mechanistic study explores the indirect effect of the secretome of PLX-RAD cells in the rescue of the irradiated mice...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
Beverley Burrell, Jennifer Jordan, Marie Crowe, Amanda Wilkinson, Virginia Jones, Shirley Harris, Deborah Gillon
Self-management programmes provide strategies to optimise health while educating and providing resources for living with enduring illnesses. The current paper describes the development of a community-based programme that combines a transdiagnostic approach to self-management with mindfulness to enhance psychological coping for older people with long-term multimorbidity. The six steps of intervention mapping (IM) were used to develop the programme. From a needs assessment, the objectives of the programme were formulated; the theoretical underpinnings then aligned to the objectives, which informed programme design, decisions on implementation, programme adoption and evaluation steps...
October 17, 2018: Nursing Inquiry
Se Pyeong Im, Jaesung Kim, Jung Seok Lee, Si Won Kim, Jae Wook Jung, Jassy Mary S Lazarte, Jong Yong Kim, Young Rim Kim, Jeong Ho Lee, Roger S M Chong, Tae Sung Jung
The variable lymphocyte receptor (VLR) B of jawless vertebrates functions as a secreted Ab of jawed vertebrates and has emerged as an alternative Ab with a single polypeptide chain. After observing an upregulated VLRB response in hagfish immunized with avian influenza virus (AIV) subtype H9N2, we screened AIV H9N2-specific VLRB using a mammalian expression system. To improve the binding avidity of the Ag-specific VLRB to the Ag, we enabled multimerization of the VLRB by conjugating it with C-terminal domain of human C4b-binding protein...
October 17, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Jae Hyoung Im, JiHyeon Baek, Areum Durey, Hea Yoon Kwon, Moon-Hyun Chung, Jin-Soo Lee
BACKGROUND: Bites with tick-borne pathogens can cause various bacterial, viral, or parasitic diseases in humans. Tick-transmitted diseases are known as contributing factors to the increasing incidence and burden of diseases. The present article investigated the epidemiology of tick-borne diseases in South Korea. METHODS: The incidence and distribution of common tick-borne diseases in Korea (Lyme disease, Q fever, and severe fever with thrombocytopenia syndrome [SFTS]) were investigated and analyzed, using data from the Korea Centers for Disease Control and Prevention (KCDC) infectious disease reporting system...
October 17, 2018: Vector Borne and Zoonotic Diseases
Qi Lai, Qing Liu, Ying He, Kai Zhao, Chiyu Wei, Lukasz Wojtas, Xiaodong Shi, Zhiguang Song
1,2,3-Triazole-imidazole derivatives (TA-IM) were prepared as fluorescent probes for silver ion detection. The design principle is the incorporation of an intramolecular H-bond between the imidazole and triazole moiety that enables a co-planar conformation to achieve fluorescence emission in the UV-blue range. Screening of different metal ions revealed excellent binding affinity of this new class of compounds toward silver ions in aqueous solution. The novel probe provided ultrafast detection (<30 s) even for a very low concentration of silver ions (in the nM range) with good linear correlation, making it a practical sensor for detection of silver ions...
October 17, 2018: Organic & Biomolecular Chemistry
Hun Lee, David Sung Yong Kang, Byoung Jin Ha, Jin Young Choi, Eung Kweon Kim, Kyoung Yul Seo, Tae Im Kim
PURPOSE: To investigate biomechanical properties of the cornea using a dynamic Scheimpflug analyzer according to age. MATERIALS AND METHODS: In this prospective, cross-sectional, observational study, participants underwent ophthalmic investigations including corneal biomechanical properties, keratometric values, intraocular pressure (IOP), and manifest refraction spherical equivalent (MRSE). We determined the relationship of biomechanical parameters and ocular/systemic variables (participant's age, MRSE, IOP, and mean keratometric values) by piecewise regression analysis, association of biomechanical parameters with variables by Spearman's correlation and stepwise multiple regression analyses, and reference intervals (RI) by the bootstrap method...
November 2018: Yonsei Medical Journal
Darpan Bhargava, Rajkumar Ahirwal, Ganesh Koneru, Balaji R Srikanth, Sivakumar Beena
PURPOSE: To determine the quantity of dexamethasone plasma concentration achieved following intrapterygomandibular space injection of dexamethasone when co-administered with inferior alveolar nerve block correlating with the clinical effects in the postoperative phase. OBJECTIVE: A preliminary prospective study to evaluate the dexamethasone plasma concentration achieved following intrapterygomandibular space injection of dexamethasone with 2% lignocaine inferior alveolar nerve block to achieve hemi-mandibular anesthesia for minor oral surgical procedures and derive clinical correlations...
October 16, 2018: Oral and Maxillofacial Surgery
E Troja, G Ryan, L Piro, H van Eerten, S B Cenko, Y Yoon, S-K Lee, M Im, T Sakamoto, P Gatkine, A Kutyrev, S Veilleux
The recent discovery of a gamma-ray burst (GRB) coincident with the gravitational-wave (GW) event GW170817 revealed the existence of a population of low-luminosity short duration gamma-ray transients produced by neutron star mergers in the nearby Universe. These events could be routinely detected by existing gamma-ray monitors, yet previous observations failed to identify them without the aid of GW triggers. Here we show that GRB150101B is an analogue of GRB170817A located at a cosmological distance. GRB150101B is a faint short burst characterized by a bright optical counterpart and a long-lived X-ray afterglow...
October 16, 2018: Nature Communications
Emily Camilleri, Amel Dudakovic, Scott M Riester, Catalina Galeano-Garces, Christopher R Paradise, Elizabeth W Bradley, Meghan E McGee-Lawrence, Hee-Jeong Im, Marcel Karperien, Aaron J Krych, Jennifer J Westendorf, A Noelle Larson, Andre J van Wijnen
Ezh2 is a histone methyltransferase that suppresses osteoblast maturation and skeletal development. We evaluated the role of Ezh2 in chondrocyte lineage differentiation and endochondral ossification.Ezh2 was genetically inactivated in the mesenchymal, osteoblastic, and chondrocytic lineages in mice using the Prrx1-Cre, Osx1-Cre, and Col2a1-Cre drivers, respectively. Wild-type and conditional knockout mice were phenotypically assessed by gross morphology, histology, and micro-CT imaging. Ezh2-deficient chondrocytes in micromass culture models were evaluated using RNA-sequencing, histologic evaluation, and western blotting...
October 16, 2018: Journal of Biological Chemistry
Soyoung Im, Uiju Cho, Hyun Joo Choi, Sang Won Lee, Changyoung Yoo
No abstract text is available yet for this article.
October 16, 2018: International Journal of Surgical Pathology
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