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Hailong Liu, Liang Xuan, Jing Zhou, Dongmei Zhou, Yujun Wang
The study was endeavored to investigate the effects of soil properties on the acute and chronic cadmium (Cd) toxicities to Folsomia candida (Collembola F. candida). Results of the present study indicated that 10% lethal concentrations (LC10) in a period of 7 days were ranged from 68.6 to > 1000 mg/kg Cd. Soil Cd concentrations that halve F. candida reproductions (EC50, 28 days) were ranged from 41.4 to 146.8 mg/kg. Stepwise regression analysis between the thresholds of Cd toxicity and soil properties revealed that the pH and organic matter (OM) were two fundamental factors for the assessment of biological threats posed by Cd...
December 7, 2018: Bulletin of Environmental Contamination and Toxicology
Patrícia M Oba, Pamela L Utterback, Carl M Parsons, Maria R C de Godoy, Kelly S Swanson
Chicken-based ingredients are commonly used in pet food products, but vary greatly in nutrient composition and processing conditions that may affect their protein quality and digestibility. Testing the quality of protein sources undergoing different processing conditions provides important information to pet food producers. The objective of this study was to determine the chemical composition, nutrient digestibility, protein, and amino acid (AA) digestibility scores, and nitrogen-corrected true metabolizable energy (TMEn) of chicken-based ingredients that had undergone different processing conditions (i...
December 11, 2018: Journal of Animal Science
Katia Rupel, Luisa Zupin, Andrea Colliva, Anselmo Kamada, Augusto Poropat, Giulia Ottaviani, Margherita Gobbo, Lidia Fanfoni, Rossella Gratton, Massimo Santoro, Roberto Di Lenarda, Matteo Biasotto, Serena Zacchigna
Photobiomodulation (PBM) is emerging as an effective strategy for the management of multiple inflammatory conditions, including oral mucositis (OM) in cancer patients who receive chemotherapy or radiotherapy. Still, the poor understanding of the mechanisms by which the light interacts with biological tissues and the heterogeneity of light sources and protocols employed worldwide significantly limits its applicability. Reactive oxygen species (ROS) are massively generated during the early phases of OM and play a major role in the pathogenesis of inflammation in general...
2018: Oxidative Medicine and Cellular Longevity
Mi-Jeong Lee, R Taylor Pickering, Varuna Shibad, Yuanyuan Wu, Kalypso Karastergiou, Mike Jager, Matthew D Layne, Susan K Fried
Visceral obesity is associated with insulin resistance and higher risk of type 2 diabetes and metabolic diseases. A limited ability of adipose tissues to remodel through the recruitment and differentiation of adipose stem cells (ASCs) is associated with adipose tissue inflammation and fibrosis and the metabolic syndrome. We show that the lower adipogenesis of omental (Om) compared to abdominal subcutaneous (Abdsc) ASCs was associated with higher secretion of TGFβ ligands that acted in an autocrine/paracrine loop to activate SMAD2 and suppress adipogenesis...
December 7, 2018: Diabetes
Sara Bouaroudj, Ahmed Menad, Azeddine Bounamous, Hocine Ali-Khodja, Abdelfettah Gherib, Dana E Weigel, Haroun Chenchouni
Beni Haroun Dam is a vital water resource for both potable water and irrigation in eastern Algeria. This study assessed water quality at the dam and investigated the impacts of this water on some soil characteristics of irrigated lands. The physicochemical parameters of the water were measured monthly at eight sites and related to soil characteristics sampled from six irrigated areas, which were compared to non-irrigated soils. The chemical facies of the water were chloride sulfate and calcium magnesium. The water had low levels of cadmium (8...
December 3, 2018: Chemosphere
Elio Mazzone, Sophie Knipper, Francesco A Mistretta, Zhe Tian, Felix Preisser, Andrea Gallina, Denis Soulieres, Derya Tilki, Francesco Montorsi, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Juan Wisnivesky, Pierre I Karakiewicz
BACKGROUND: Patients with organ confined muscle-invasive bladder cancer (MIBC) who are candidates for radical cystectomy (RC) should receive neoadjuvant chemotherapy (CHT). However, the most contemporary CHT use rates indicate low adherence to these guidelines. We tested contemporary neoadjuvant CHT rates and associated cancer-specific mortality (CSM) and overall mortality (OM) in pT2N0 MIBC patients treated with RC. MATERIALS AND METHODS: Within the SEER database (2004-2015), we identified patients with pT2N0 MIBC patients who underwent RC...
December 5, 2018: Cancer Epidemiology
Sang Yong Om, Euihong Ko, Jung-Min Ahn, Do-Yoon Kang, Kyusup Lee, Osung Kwon, Pil Hyung Lee, Seung-Whan Lee, Ho Jin Kim, Joon Bum Kim, Suk Jung Choo, Duk-Woo Park, Seung-Jung Park
Obesity and overweight have been associated with better clinical outcomes in different populations with a diverse spectrum of cardiovascular disease (obesity paradox). However, conflicting data exist about the relation between body mass index (BMI) and outcomes after transcatheter aortic valve implantation (TAVI). The aim of this study is to evaluate the association of body mass index with clinical outcomes in patients with severe aortic stenosis (AS) who underwent TAVI. The study cohort included 379 consecutive patients with symptomatic severe AS who underwent TAVI between March 2010 and February 2017 in 3 centers in East Asia...
November 24, 2018: American Journal of Cardiology
Jishao Jiang, Kang Kang, Chenjing Wang, Xingju Sun, Sen Dang, Nian Wang, Yang Wang, Chunyan Zhang, Guangxuan Yan, Yunbei Li
The aim of this work was to compare the impact of different adding forms of dicyandiamide (DCD) on NH3 and greenhouse gas (GHG) emissions during sewage sludge (SS) composting. Four treatments were set up using SS mixed with sawdust, to which DCD was then added by mixing (M), surface broadcasting (B), and a combination of the two (M+B). The treatment without DCD applied was used as the control. The results indicate that the addition of DCD slightly inhibited the organic matter (OM) degradation, but that it had no significant effect on CO2 emission...
November 2018: Waste Management
Toshitsugu Sugimoto, Daisuke Inoue, Masayuki Maehara, Ichiro Oikawa, Takashi Shigematsu, Yoshiki Nishizawa
Limited data are available on the safety and efficacy of anti-resorptive agents, particularly once-monthly bisphosphonates, for use in osteoporotic patients with chronic kidney disease (CKD). We conducted a post hoc analysis of data from a 12-month, randomized, double-blind, phase III study to evaluate the safety and efficacy of once-monthly risedronate (RIS-OM) 75 mg tablets in Japanese osteoporosis patients with mild-to-moderate CKD. Patients who received RIS-OM 75 mg were stratified by baseline estimated glomerular filtration rate (eGFR; ≥ 90, ≥ 60 to < 90, or ≥ 30 to < 60 mL/min/1...
December 6, 2018: Journal of Bone and Mineral Metabolism
Caroline A Bulstra, Epke A Le Rutte, Paritosh Malaviya, Epco C Hasker, Luc E Coffeng, Albert Picado, Om Prakash Singh, Marleen C Boelaert, Sake J de Vlas, Shyam Sundar
BACKGROUND: Despite the overall decrease in visceral leishmaniasis (VL) incidence on the Indian subcontinent, there remain spatiotemporal clusters or 'hotspots' of new cases. The characteristics of these hotspots, underlying transmission dynamics, and their importance for shaping control strategies are not yet fully understood and are investigated in this study for a VL endemic area of ~100,000 inhabitants in Bihar, India between 2007-2015. METHODOLOGY/PRINCIPAL FINDINGS: VL incidence (cases/10,000/year) dropped from 12...
December 2018: PLoS Neglected Tropical Diseases
Balasubramani Ravindran, Dinh Duc Nguyen, Dhiraj Kumar Chaudhary, Soon Woong Chang, Jaisoo Kim, Sang Ryong Lee, JoungDu Shin, Byong-Hun Jeon, SeokJoo Chung, JaeJoung Lee
Excessive nutrients and toxic gas emissions from animal manure management are of great global concern, with negative environmental and economic consequences worldwide. Due to biochar recalcitrance and sorption properties, this study investigated the effect of the biochar(BC) derived from bamboo, amendment on swine manure(SM) composting efficiency through physical, physio-chemical, gaseous emissions, microbiological, and phytotoxic analysis during the 56 day process of in-vessel composting. The treatments were set-up from different ratios of biochar to swine manure mixed with sawdust(SD)(i...
December 2, 2018: Journal of Environmental Management
Alexandre R Carvalho, Solange Guizilini, Gustavo M Murai, Isis Begot, Isadora S Rocco, Nelson A Hossne, Eduardo G Chamlian, João Manoel T Santos, Ricardo A Macedo, Gustavo C O Lisboa, Alberto C Nasciutti, Carlos Eduardo R Santos, João Paulo M Figueiredo, Walter J Gomes
OBJECTIVE: To evaluate the sequential changes of hemodynamic and metabolic parameters in patients who underwent aorta no-touch off-pump coronary artery bypass surgery (OPCAB). METHODS: Prospective study involving twenty-seven consecutive patients who underwent aorta no-touch OPCAB. The FloTrac/PreSep/Vigileo™ system (Edwards Lifesciences) was used to continuously record heart rate (HR), mean arterial blood pressure (MABP), central venous pressure (CVP), continuous cardiac index (FCI), stroke volume (SV), stroke volume variation (SVV), and central venous oxygen saturation (ScvO2)...
September 2018: Brazilian Journal of Cardiovascular Surgery
Alexsandra F DE Queiroz, Alessandra M Salviano, Tony J F DA Cunha, Nelci Olszevski, Valdomiro S DE Souza Júnior, Manoel B DE Oliveira Neto
The objective of this study was to evaluate the potentialities and limitations of the agricultural use of representative classes of semi-arid regions of the state of Bahia, based on the pedological and evaluation of their soil characteristics. Five areas were selected where trenches were opened to collect samples for the analyses: Eutric Haplustept which presents vulnerability to physical and chemical degradation due to poor drainage with risks of erosion, waterlogging, salinization and compaction but having good natural fertility; Abrupt Kandiustalf with high vulnerability to physical degradation due to the presence of gravel and pebbles which may limit the development of deep rooting plants and mechanization but also with good natural fertility; Typic quartzipsaments and Typic Eutrustalf with no limitations related to drainage as low risk of compaction but featuring limitation of low moisture-holding capacity and nutrients; and Arenic Haplustulf wose characteristics are high vulnerability to degradation due to the drainage limitation related to the Btx horizon cementing in addition to low natural fertility and therefore is not recommended to agricultural use...
October 2018: Anais da Academia Brasileira de Ciências
Ameerah Alsaqobi, Nabeel Al-Brahim
Background: The transformation of nonosseous soft tissue into bone is known as osseous metaplasia (OM). This condition most commonly affects the musculoskeletal and central nervous systems and it is a well-known phenomenon in different soft tissue organs. Rarely, OM can affect the uterus, which can extend into the cervix. OM affecting the cervix alone is a more rare condition that has multiple different clinical presentations. The presentation can be similar to that of a tumor in extremely rare cases...
2018: Case Reports in Pathology
Aanchal Kashyap, Pankaj Kumar Singh, Om Silakari
Tuberculosis (TB) is contagious in nature and immunocompromised patients have a higher probability of developing TB. The occurrence of drug resistance, has led to serious health concerns in the management of TB. In order to combat resistant tuberculosis there is an urgent need of identifying new drug targets and new drug combinations for the effective management and reduction in the duration of TB treatment. Targeting DNA gyrase that is involved in bacterial replication cycle, provides one rationale approach...
December 2018: Tuberculosis
Cristiano de Queiroz Mendonca, Marcelle Vieira Freire, Simone Santana Viana, Mayo Kayann Guerra Silva Tavares, Wallace Marcelo Almeida Silva, Rosana Cipolotti
OBJECTIVE: To characterize ocular manifestations (OM) of pediatric patients treating for acute lymphoblastic leukemia (ALL) and to evaluate whether they are associated with well-described predictive risk factors for relapse, protocol (1999 or 2009), gender and cerebrospinal fluid infiltration. METHODS: A prospective cohort study was conducted in children and adolescents with ALL from January 2013 to December 2017. The patients underwent ophthalmologic evaluations before starting treatment (D0), on the eighth day (D8), at the 28th day (D28), and at six months (D6 months)...
November 29, 2018: Leukemia Research
Moritz Balkenhohl, Benjamin Heinz, Thomas Abegg, Paul Knochel
The amination of various phosphorodiamidate-substituted pyridines, quinolines, and quinoxaline with magnesium amides R2 NMgCl·LiCl proceeds at room temperature within 8 h. Several pharmaceutically active amines were suitable substrates for this amination procedure, and also the antihistaminic tripelennamine was prepared. Additionally, several heterocyclic phosphorodiamidates underwent directed ortho-metalation (D oM) using TMPMgCl·LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) or TMP2 Mg·2LiCl, followed by electrophilic functionalization prior to the amination step, which led to ortho-functionalized aminated N-heterocycles...
December 4, 2018: Organic Letters
Vahid Zadmajid, Ian Anthony Ernest Butts
As global aquaculture continues to expand, increasing efforts are focusing on assisted reproductive technologies. This study sought to test whether salmon GnRH [D-Arg6, Pro9NEt]) analogue (sGnRHa) + domperidone injection at 0.25 mL/body weight (BW; 5-μg sGnRHa + 2.5-mg domperidone), 0.5 mL/kg BW (10-μg sGnRHa + 5-mg domperidone), or 1.0 mL/kg BW (20-μg sGnRHa + 10-mg domperidone) affects spawning performance and gamete quality in wild-caught Levantine scraper, Capoeta damascina. The ability of these treatments to elicit a response was further examined by in vivo stimulation of estradiol (E2) and 17α,20β-dihydroxy-4-pregnen-3-one (DHP) and by its in vivo potency to induce oocyte maturation (OM)...
December 3, 2018: Journal of Animal Science
M E Garcia-Ascolani, T M Schulmeister, M Ruiz-Moreno, D D Henry, F M Ciriaco, G M Silva, E Block, J C B Dubeux, G C Lamb, N DiLorenzo
In Phase 1 (d 0 to 56) of a two-phase experiment, 81 steers (initial body weight = 189 ± 22 kg) were arranged in a generalized randomized block design, allocated to 9 pens (9 steers/pen) and assigned to 1 of 3 dietary treatments. Treatments consisted of different inclusion rates of Fermenten (FER) in a backgrounding diet fed ad libitum, and were as follow: 0 (CON), 2, or 4% FER in the diet dry matter (DM). Steer was considered the experimental unit, and individual DM intake was measured using the GrowSafe system...
December 2, 2018: Journal of Animal Science
Dan Wang, Ning-Xin Zhu, Man Qin, Yuan-Yuan Wang
OBJECTIVE: This study aimed to investigate the anti-inflammatory effect of betamethasone on LPS-stimulated human dental pulp stem cells (DPSCs) and its associated mechanism. The osteo-/odontogenic differentiation and osteoclast effect of betamethasone on DPSCs and stem cells from human exfoliated deciduous teeth (SHED) were evaluated. DESIGN: The proliferative effect of betamethasone on DPSCs was analyzed using a cholecystokinin octapeptide assay. The anti-inflammatory effect of betamethasone was investigated using quantitative polymerase chain reaction (qPCR) and ELISA...
November 20, 2018: Archives of Oral Biology
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