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Om Prakash Suthar, Shyam Mathur, Vikas Gupta, Harish Agarwal, Arvind Mathur, Pradeep Singh, Sohan Lal Sharma
Introduction: Vitamin D deficiency is highly prevalent condition in western countries as well as in India. Lower level of vitamin D is associated with increased arterial stiffness by activating renin-angiotensin-aldosterone system leading to increased cardiovascular morbidity and mortality including increased risk of coronary artery disease, stroke, peripheral vascular disease, hypertension, diabetes mellitus and metabolic syndrome. Our aim was to study the correlation between serum vitamin D level, various measures of arterial stiffness and cardiovascular morbidity in elderly individuals...
March 2018: Journal of the Association of Physicians of India
Vasiliy Rosen, Yona Chen
Soil vulnerability to heavy metal pollution is low in soils exhibiting an ability to strongly adsorb heavy metals on their geochemical fractions. Organic matter (OM) is among other components of soils, one of the most effective sorbing fractions. Compost addition is often used for soil remediation thereby enriching the soil with OM. However, compost is often enriched with heavy metals and thereby may induce adverse effects on the soil and plants growing in them. Compost-derived dissolved organic matter (DOM) can mobilize heavy metals...
October 19, 2018: Environmental Science and Pollution Research International
Nida Gul, Bushra Khan, Hizbullah Khan, Muhammad Israr
From health and environmental point of views, dioxins are important due to their toxicity and persistence. Dioxins have the potential to reside in the environment for longer time if sorbed onto the clay and organic content of the soil matrix. Their transport or leaching under certain environmental conditions such as preferential flow can increase the risk of groundwater contamination. In the current study, breakthrough curves (BTCs) against time were plotted for selected dioxin transport prediction; based on measured distribution coefficient (Kd ), dispersion coefficient (D), and retardation factor (R)...
October 18, 2018: Environmental Monitoring and Assessment
H X Sui, P J Lv, Y Wang, Y C Feng
OBJECTIVE: To explore the effects of low level laser irradiation (LLLI) on the osteogenic capacity of three-dimensional (3D) structure by 3D bio-printing construct used human adipose-derived stem cells (hASCs) as seed cells. METHODS: Using hASCs as seed cells, we prepared sodium alginate/gelatin/hASCs 3D bio-printing construct, and divided them into four groups: PM (proliferative medium), PM+LLLI, OM (osteogenic medium) and OM+LLLI, and the total doses of LLLI was 4 J/cm²...
October 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Eva Bauwens, Myrthe Joosten, Joemar Taganna, Mirko Rossi, Ayla Debraekeleer, Alfred Tay, Fanny Peters, Steffen Backert, James Fox, Richard Ducatelle, Han Remaut, Freddy Haesebrouck, Annemieke Smet
Helicobacter (H.) pylori is an important risk factor for gastric malignancies worldwide. Its outer membrane proteome takes an important role in colonization of the human gastric mucosa. However, in zoonotic non-H. pylori helicobacters (NHPHs) also associated with human gastric disease, the composition of the outer membrane (OM) proteome and its relative contribution to disease remain largely unknown. By means of a comprehensive survey of the diversity and distribution of predicted outer membrane proteins (OMPs) identified in all known gastric Helicobacter species with fully annotated genome sequences, we found genus- and species-specific families known or thought to be implicated in virulence...
October 18, 2018: Scientific Reports
Xinping Zhang, Fangfang Zhang, Dexiang Wang, Junxi Fan, Youning Hu, Haibin Kang, Mingjie Chang, Yue Pang, Yang Yang, Yang Feng
Although the spatial mapping and fertility assessment of soil chemical properties (SCPs) are well studied in the Loess Plateau region of China at farmland scale, little is known about spatial mapping the SCPs and their fertility and their influence factors at urban forest scale. The objectives of this study were to (1) compare the performance of two spatial interpolation methods, Ordinary kriging (OK) and regression kriging (RK), and (2) explain the relationships of the vegetation, terrain, and soil layer depth between the eight SCPs and their fertility, and (3) find the limiting factors of soil comprehensive fertility in this study area? The Yan'an urban forest was taken as study case, used hybrid spatial interpolation methods based on OK and RK to mapping eight SCPs and the soil fertility in each soil layer (0-20 cm, 20-40 cm, and 40-60 cm) for 285 soil samples...
2018: PloS One
Luke V Blakeway, Aimee Tan, Rachael Lappan, Amir Ariff, Janessa L Pickering, Christopher S Peacock, Christopher C Blyth, Charlene M Kahler, Barbara J Chang, Deborah Lehmann, Lea-Ann S Kirkham, Timothy F Murphy, Michael P Jennings, Lauren O Bakaletz, John M Atack, Ian R A Peak, Kate L Seib
Moraxella catarrhalis is a human-adapted pathogen, and a major cause of otitis media (OM) and exacerbations of chronic obstructive pulmonary disease (COPD). The species is comprised of two main phylogenetic lineages, RB1 and RB2/3. Restriction-modification (R-M) systems are among the few lineage-associated genes identified in other bacterial genera, and have multiple functions including defence against foreign invading DNA, maintenance of speciation, and epigenetic regulation of gene expression. Here we define the repertoire of R-M systems in 51 publicly available M...
October 18, 2018: Genome Biology and Evolution
Om Prakash Sanjeev, Soumya Sankar Nath, Deepak Malviya, Subhas Singh Rajput
We are presenting a case of the right atrial myxoma found in a case of rheumatic heart disease. During transthoracic echocardiography for the evaluation of a suspected rheumatic valvular heart disease, a diagnosis of severe mitral stenosis with severe mitral regurgitation with the right atrial thrombus was made. On transesophageal echocardiography, a pedunculated mass in the right atrium was confirmed. In the course of surgery, it was found that there is a tumor originating from the right atrial appendage (RAA) which was confused with clot on echocardiography...
October 2018: Annals of Cardiac Anaesthesia
Elio Mazzone, Marco Bandini, Felix Preisser, Sebastiano Nazzani, Zhe Tian, Firas Abdollah, Denis Soulieres, Markus Graefen, Francesco Montorsi, Shahrokh Shariat, Fred Saad, Alberto Briganti, Pierre Karakiewicz
INTRODUCTION: Local therapy (LT) may offer a survival advantage in highly select newly diagnosed metastatic prostate cancer (mPCa) patients. However, it is unknown whether the benefits vary according to Caucasian vs. African American (AA) patients. METHODS: Within the Surveillance Epidemiology and End Results database (2004-2014), we focused on Caucasians and AA patients with newly diagnosed mPCa treated with LT: radical prostatectomy (RP) and brachytherapy (RT)...
October 15, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Rachael L Hardison, Alistair Harrison, Rachel M Wallace, Derek R Heimlich, Meghan E O'Bryan, Robert P Sebra, Heather W Pinkett, Sheryl S Justice, Kevin M Mason
Bacterial pathogens must sense, respond and adapt to a myriad of dynamic microenvironmental stressors to survive. Adaptation is key for colonization and long-term ability to endure fluctuations in nutrient availability and inflammatory processes. We hypothesize that strains adapted to survive nutrient deprivation are more adept for colonization and establishment of chronic infection. In this study, we detected microevolution in response to transient nutrient limitation through mutation of icc. The mutation results in decreased 3',5'-cyclic adenosine monophosphate phosphodiesterase activity in nontypeable Haemophilus influenzae (NTHI)...
October 17, 2018: PLoS Pathogens
Anquan Peng, Xinming Yang, Weijing Wu, Zian Xiao, Dinghua Xie, Shenglei Ge
BACKGROUND AND OBJECTIVE: It has been recognized that anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides may lead to hypertrophic pachymeningitis (HP) or intractable otitis media (OM). To our knowledge, few cases of coexistent ANCA-related HP and OM have been described previously. To increase awareness of this disease, we reviewed the literature describing patients with HP and intractable OM in a population with AAV to guide clinical decision making for otolaryngologists...
October 17, 2018: European Archives of Oto-rhino-laryngology
Nicholas J Short, Elias Jabbour, Kiran Naqvi, Ami Patel, Jing Ning, Koji Sasaki, Graciela M Nogueras-Gonzalez, Prithviraj Bose, Steven M Kornblau, Koichi Takahashi, Michael Andreeff, Gabriela Sanchez-Petitto, Zeev Estrov, Courtney D Dinardo, Guillermo Montalban-Bravo, Marina Konopleva, Yesid Alvarado, Kapil N Bhalla, Warren Fiskus, Maria Khouri, Rubiul Islam, Hagop Kantarjian, Guillermo Garcia-Manero
The outcome of patients with myelodysplastic syndromes (MDS) after failure of hypomethylating agents (HMAs) failure is poor with a median overall survival (OS) of only 4-6 months. Omacetaxine mepesuccinate (OM) is safe and effective in myeloid malignancies but has not been studied in MDS with HMA failure. We conducted a phase II study of OM in patients with MDS or chronic myelomonocytic leukemia (CMML) who had previously failed or been intolerant to HMAs. Patients received OM at a dose of 1.25 mg/m2 subcutaneously every 12 hours for 3 consecutive days on a 4-7 week schedule...
October 17, 2018: American Journal of Hematology
A Brzozowska, R Mlak, P Gołębiowski, T Małecka-Massalska
BACKGROUND: Apart from surgery, the methods of treatment of HNC are radiotherapy (RTH) and/or chemotherapy (CRTH/CHT). One of the most frequent and serious complications of RTH is oral mucositis (OM). There is a strict correlation between the inflammation and the status of hydration. The aim of the study was to evaluate the changes in hydration, occurring in the course of RTH, measured by means of bioelectrical impedance analysis (BIA) and to analyze them in correlation with the intensification of OM in HNC patients...
October 16, 2018: Clinical & Translational Oncology
Om Ganda
PURPOSE OF REVIEW: Statins are the most evidence-based therapy to target LDL-C to reduce atherosclerotic events. Yet, many people are unable to achieve adequate reduction in this key atherogenic factor. Moreover, residual risk of cardiovascular events may persist even after "optimal" LDL-C due to elevations in triglyceride-rich lipoproteins. Therefore, additional therapies beyond statins are needed, particularly in patients with diabetes. RECENT FINDINGS: Clinical trials with ezetimibe and PCSK9 inhibitors have reported further reductions in cardiovascular events, beyond statins...
October 15, 2018: Current Diabetes Reports
Sai Gong, Chen Chen, Jingxian Zhu, Guangyao Qi, Shuxia Jiang
Background: Cultivating the wine-cap mushroom ( Stropharia rugosoannulata ) on forestland has become popular in China. However, the effects of wine-cap Stropharia cultivation on soil nutrients and bacterial communities are poorly understood. Methods: We employed chemical analyses and high-throughput sequencing to determine the impact of cultivating the wine-cap Stropharia on soil nutrients and bacterial communities of forestland. Results: Cultivation regimes of Stropharia on forestland resulted in consistent increases of soil organic matter (OM) and available phosphorus (AP) content...
2018: PeerJ
Kelly M Storek, Rajesh Vij, Dawei Sun, Peter A Smith, James T Koerber, Steven T Rutherford
Integral β-barrel membrane proteins are folded and inserted into the Gram-negative bacterial outer membrane by the β-barrel assembly machine (BAM). This essential complex, comprised of a β-barrel protein, BamA, and four lipoproteins, BamB, BamC, BamD, and BamE, resides in the outer membrane, a unique asymmetrical lipid bilayer that is difficult to recapitulate in vitro Thus, probing BAM function in living cells is critical to fully understand the mechanism of β-barrel folding. We recently identified an α-BamA monoclonal antibody, MAB1, that is a specific and potent inhibitor of BamA function...
October 15, 2018: Journal of Bacteriology
Amit Om, Anjali Om
The objectives of this review are to demonstrate that portraits, in their visual reflections of subjects faces and expressions, offer significant representations relevant to the field of dermatology and bring attention to an underappreciated aesthetic of dermatological conditions. The review comprises paintings that purposefully or inadvertently depict dermatological conditions. The findings were substantiated by searching PubMed using the keywords art , painting , and dermatology , as well as combinations of these terms...
September 2018: Journal of Clinical and Aesthetic Dermatology
Oguzhan Sunamak, Turgut Donmez, Dogan Yildirim, Adnan Hut, Vuslat Muslu Erdem, Duygu Ayfer Erdem, Ibrahim Halil Ozata, Mikail Cakir, Sinan Uzman
Introduction: Mesh placement is the main standard in repair of inguinal hernia, and laparoscopic repair is the standard of care via spinal, epidural, or combined anesthesia. Here, we compared open and laparoscopic total extraperitoneal (TEP) repairs under general (GA) and spinal anesthesia (SA). Methods: Inguinal hernia patients (n=440) were analyzed retrospectively. There were four groups: Group 1 was TEP under GA (TEP-GA) (n=111); Group 2 was open mesh repair (OM) under SA (n=116) (OM-SA); Group 3 was open mesh repair under GA (n=117) (OM-GA); Group four was TEP under SA (n=96) (TEP-SA)...
2018: Therapeutics and Clinical Risk Management
Caterina Magnani, Diana Giannarelli, Alice Calvieri, Ana Dardeli, Giovanni Eusepi, Maria Rosa Restuccia, Chiara Mastroianni, Giuseppe Casale
BACKGROUND: Various options for the pharmacological treatment of breakthrough cancer pain (BTcP) are available. International guidelines on BTcP treatment are not univocal. A tailored treatment should be based on the assessment of different variables such as BTcP characteristics, oral mucositis, chronic rhinitis and a patient's ability to take medication. OBJECTIVE: The goal of this study is to assess the relationship between these variables and the medication treatment for BTcP in a sample of patients with terminal cancer...
October 13, 2018: Postgraduate Medical Journal
Nadia Prays, Peter Dominik, Anja Sänger, Uwe Franko
A variety of biogas residues (BGRs) have been used as organic fertilizer in agriculture. The use of these residues affects the storage of soil organic matter (SOM). In most cases, SOM changes can only be determined in long-term observations. Therefore, predictive modeling can be an efficient alternative, provided that the parameters required by the model are known for the considered BGRs. This study was conducted as a first approach to estimating the organic matter (OM) turnover parameters of BGRs for process modeling...
2018: PloS One
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