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Habiba Elfandy, Joshua Armenia, Filippo Pederzoli, Eli Pullman, Nelma Pértega-Gomes, Nikolaus Schultz, Kartik Viswanathan, Aram Vosoughi, Mirjam Blattner, Konrad H Stopsack, Giorgia Zadra, Kathryn L Penney, Juan Miguel Mosquera, Svitlana Tyekucheva, Lorelei A Mucci, Christopher Barbieri, Massimo Loda
Among prostate cancers (PCa) containing Gleason pattern 4, cribriform morphology is associated with unfavorable clinico-pathologic factors, but its genetic features and association with long-term outcomes are incompletely understood. In this study, genetic, transcriptional and epigenetic features of invasive cribriform carcinoma (ICC) tumors were compared to non-cribriform Gleason 4 (NC4) in The Cancer Genome Atlas (TCGA) cohort. ICC (n=164) had distinctive molecular features when compared to NC4 (n=102). These include: 1) Increased somatic copy number variations, specifically deletions at 6q, 8p which encompassed PTEN and MAP3K7 losses and gains at 3q; 2) Increased SPOPmut and ATMmut; 3) Enrichment for mTORC1 and MYC pathways by gene expression; 4) Increased methylation of selected genes...
October 17, 2018: Molecular Cancer Research: MCR
Sara Zamani, Amir Sohrabi, Seyed Masoud Hosseini, Marjan Rahnamaye-Farzami, Abolfazl Akbari
BACKGROUND: Early diagnosis is an important factor to improve survival of invasive cervical cancer (ICC) patients. Molecular biomarkers such as micro RNA (miRNA) can be used in the early detection of ICC. The expression of miR-21 and miR-29a are deregulated in many types of human cancers. OBJECTIVE: The aim of this study was to investigate the differences in miR-21 and miR-29a expression patterns in Human Papilloma Virus (HPV) infection and various grades of cervical cancer among Iranian women...
October 17, 2018: MicroRNA
Rachael L Hardison, Alistair Harrison, Rachel M Wallace, Derek R Heimlich, Meghan E O'Bryan, Robert P Sebra, Heather W Pinkett, Sheryl S Justice, Kevin M Mason
Bacterial pathogens must sense, respond and adapt to a myriad of dynamic microenvironmental stressors to survive. Adaptation is key for colonization and long-term ability to endure fluctuations in nutrient availability and inflammatory processes. We hypothesize that strains adapted to survive nutrient deprivation are more adept for colonization and establishment of chronic infection. In this study, we detected microevolution in response to transient nutrient limitation through mutation of icc. The mutation results in decreased 3',5'-cyclic adenosine monophosphate phosphodiesterase activity in nontypeable Haemophilus influenzae (NTHI)...
October 17, 2018: PLoS Pathogens
Daniela Carvalho, Pedro Aguiar, Antero Palma-Carlos
INTRODUCTION: There is an increasing interest regarding the impact of skin diseases on quality of life. Skindex-29 is a questionnaire developed to evaluate this impact. This study aimed to validate Skindex-29 for the Portuguese population. MATERIAL AND METHODS:  From the 81 approached patients from two clinics, only 75 finished the study: 35 with skin disease and 40 without. A translation and back-translation were performed. Concerning accuracy and discrimination power, the scores were submitted to ROC curve analysis after being compared between both groups through Mann-Whitney test...
September 28, 2018: Acta Médica Portuguesa
Daniela Bassi, Aldair Darlan Santos-de-Araújo, Patrícia Faria Camargo, Almir Vieira Dibai-Filho, Moyrane Abreu da Fonseca, Renata Gonçalves Mendes, Audrey Borghi-Silva
Heart rate variability (HRV) among other methods can be used to assess diabetic cardiac autonomic neuropathy by cardiac intervals were recorded. However, the amount of error depending on this measurement methodology is unclear. To evaluate the intra- and inter-rater reliability to calculate HRV indices, comparing different times and by different trained examiners in patients with type 2 diabetes mellitus (T2DM). Thirty individuals of both genders, aged between 18 and 45 years, with T2DM. The RR interval (RRi) were recorded during a 10 min period on supine position using a portable heart rate monitor (Polar® S810i model)...
October 16, 2018: Journal of Medical Systems
Osamu Manabe, Hiroshi Ohira, Kenji Hirata, Souichiro Hayashi, Masanao Naya, Ichizo Tsujino, Tadao Aikawa, Kazuhiro Koyanagawa, Noriko Oyama-Manabe, Yuuki Tomiyama, Keiichi Magota, Keiichiro Yoshinaga, Nagara Tamaki
PURPOSE: 18 F-fluorodeoxyglocose positron emission tomography (FDG PET) plays a significant role in the diagnosis of cardiac sarcoidosis (CS). Texture analysis is a group of computational methods for evaluating the inhomogeneity among adjacent pixels or voxels. We investigated whether texture analysis applied to myocardial FDG uptake has diagnostic value in patients with CS. METHODS: Thirty-seven CS patients (CS group), and 52 patients who underwent FDG PET/CT to detect malignant tumors with any FDG cardiac uptake (non-CS group) were studied...
October 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Hans Leung, Christopher Latella, Séverine Lamon, Ashlee M Hendy
The integrity of the corticomotor pathway is paramount in the optimal functioning of skeletal muscle. However, variability of neurophysiological assessment via peripheral nerve and transcranial magnetic stimulation can render interpretation difficult. Seldom evidence exists regarding the reliability of such measurements in the leg extensors, which have important locomotive and functional roles. This study aimed to assess the test-retest reliability of peripheral, corticospinal and intracortical responses in the vastus medialis...
2018: Frontiers in Psychology
Nicholas A Pickersgill, Joel M Vetter, Gerald L Andriole, Anup S Shetty, Kathryn J Fowler, Aaron J Mintz, Cary L Siegel, Eric H Kim
BACKGROUND: Multiparametric (mp) magnetic resonance imaging (MRI) has become an important tool for the detection of clinically significant prostate cancer. However, diagnostic accuracy is affected by variability between radiologists. OBJECTIVE: To determine the accuracy and variability in prostate mpMRI interpretation among radiologists, both individually and in teams, in a blinded fashion. DESIGN, SETTING, AND PARTICIPANTS: A study cohort (n=32) was created from our prospective registry of patients who received prostate mpMRI with subsequent biopsy...
October 13, 2018: European Urology Focus
R J Fredericksen, F M Yang, L E Gibbons, T C Edwards, S Brown, E Fitzsimmons, K Alperovitz-Bichell, M Godfrey, A Wang, A Church, C Gutierrez, E Paez, L Dant, S Loo, M Walcott, M J Mugavero, K H Mayer, W C Mathews, D L Patrick, P K Crane, H M Crane
BACKGROUND: Providers are often unaware of poor adherence to prescribed medications for their patients with chronic diseases. OBJECTIVE: To develop brief, computer-administered patient-reported measures in English and Spanish assessing adherence behaviors and barriers. Design, Participants, and Main Measures: Item pools were constructed from existing measures of medication adherence behaviors and barriers, which informed development of a patient concept elicitation interview guide to identify medication adherence behavior and barrier-related concepts...
October 5, 2018: Research in Social & Administrative Pharmacy: RSAP
Eric Chung, Dongwon Kang, Hye Sun Lee, Eun-Suk Cho, Joo Hee Kim, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
INTRODUCTION: In measuring tumor height for rectal cancer, rigid sigmoidoscopy (RS) is a standard modality, and the accuracy of magnetic resonance imaging(MRI) in patients with/without preoperative chemoradiotherapy (CRT) has not been fully investigated. The aim of this study was to investigate the accuracy of MRI for measuring tumor height. MATERIALS AND METHODS: Among rectal cancer patients seen between July 2006 and May 2012, the initial group (RS and MRI available at initial diagnosis) and the post-CRT group (RS and MRI available after the completion of preoperative CRT) were selected...
October 9, 2018: European Journal of Surgical Oncology
Angela Schlager, Kerstin Ahlqvist, Eva Rasmussen-Barr, Elisabeth Krefting Bjelland, Ronnie Pingel, Christina Olsson, Lena Nilsson-Wikmar, Per Kristiansson
BACKGROUND: Comparisons across studies of generalized joint hypermobility are often difficult since there are several classification methods and methodological differences in the performance exist. The Beighton score is most commonly used and has been tested for inter- and intra-rater reliability. The Contompasis score and the Hospital del Mar criteria have not yet been evaluated for reliability. The aim of this study was to investigate the inter- and intra-rater reliability for measurements of range of motion in joints included in these three hypermobility assessment methods using a structured protocol...
October 17, 2018: BMC Musculoskeletal Disorders
Gunnar Hägglund, Mikael Goldring, Maria Hermanson, Elisabet Rodby-Bousquet
Background and purpose - Pelvic obliquity, common in individuals with cerebral palsy (CP), changes the muscle force vector on the hip joint and probably affects the risk of hip dislocation. We evaluated a new method for measurement of hip displacement in CP that takes the pelvic obliquity into account: the pelvic adjusted migration percentage (PAMP). Children and methods - From the Swedish surveillance program for cerebral palsy (CPUP), the first pelvic radiograph of 268 children <18 years in southern Sweden during a 3-year period were evaluated...
October 17, 2018: Acta Orthopaedica
Kristamarie A Pratt, Susan M Sigward
Difficulty quantifying knee loading deficits clinically in individuals following anterior cruciate ligament reconstruction (ACLr) may underlie their persistence. Expense associated with quantifying knee moments (KMom) and power (KPow) with gold standard techniques precludes their use in the clinic. As segment and joint kinematics are used to calculate moments and power, it is possible that more accessible inertial sensor technology can be used to identify knee loading deficits. However, it is unknown if angular velocities measured with inertial sensors provide meaningful information regarding KMom/KPow during dynamic tasks post-ACLr...
October 15, 2018: Sensors
Angela Blasimann, Patric Eichelberger, Nicole Lutz, Lorenz Radlinger, Heiner Baur
BACKGROUND: The lack of reliable parameters to evaluate dynamic foot function, emphasizes the need for a deeper insight in foot biomechanics. The aims were to investigate the reliability of a new parameter (dynamic navicular rise dNR), and its relationship with the dynamic navicular drop (dND). METHODS: Twenty healthy participants (mean age 30.2±8.1years) had to walk on even ground and downstairs. Data of ten trials per task on two measurement days were recorded...
August 22, 2018: Foot
Florian Dubost, Pinar Yilmaz, Hieab Adams, Gerda Bortsova, M Arfan Ikram, Wiro Niessen, Meike Vernooij, Marleen de Bruijne
Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, are common in aging, and are considered a reflection of cerebral small vessel disease. As such, assessing the burden of PVS has promise as a brain imaging marker. Visual and manual scoring of PVS is a tedious and observer-dependent task. Automated methods would advance research into the etiology of PVS, could aid to assess what a "normal" burden is in aging, and could evaluate the potential of PVS as a biomarker of cerebral small vessel disease...
October 13, 2018: NeuroImage
Natalie M Plana, William J Rifkin, Rami S Kantar, Joshua A David, Samantha G Maliha, Scott J Farber, David A Staffenberg, Barry H Grayson, J Rodrigo Diaz-Siso, Roberto L Flores
BACKGROUND: Simulation is progressively being integrated into surgical training, yet its utility in plastic surgery has not been well described. We present a prospective, randomized, blinded trial comparing digital simulation to a surgical textbook for conceptualization of cleft-lip repair. METHODS: Thirty-five medical students were randomized to learning cleft repair using a simulator or textbook. Participants outlined markings for a standard cleft-lip repair before (pre-intervention) and after (post-intervention) 20 minutes of studying their respective resource...
October 12, 2018: Plastic and Reconstructive Surgery
Fazel Rezaei Motlagh, Hamid Pejam, Taher Babaee, Hassan Saeedi, Zahra Hedayati, Mohammad Kamali
PURPOSE: To examine the validity and reliability of the Persian versions of the Bad Sobernheim Stress Questionnaire-Deformity/Brace in adolescent idiopathic scoliosis. MATERIALS/METHODS: Persian forward/backward translation of the Bad Sobernheim Stress Questionnaire-Deformity/Brace was produced, and all stages for a cross-cultural adaptation process were carried out based on the International Quality of Life Assessment guidelines. The measurements of internal consistency and test-retest reliability were assessed by Cronbach's α and intraclass correlation coefficient (ICC), respectively...
October 16, 2018: Disability and Rehabilitation
Rafael F Coelho, Mauricio D Cordeiro, Guilherme P Padovani, Rafael Localli, Limirio Fonseca, José Pontes, Giuliano B Guglielmetti, Miguel Srougi, William Carlos Nahas
OBJECTIVE: To evaluate the length hospital stay and predictors of prolonged hospitalization after RRP performed in a high-surgical volume teaching institution, and analyze the rate of unplanned visits to the office, emergency care, hospital readmissions and perioperative complications rates. MATERIALS AND METHODS: Retrospective analysis of prospectively collected data in a standardized database for patients with localized prostate cancer undergoing RRP in our institution between January/2010 - January/2012...
September 10, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Matthew M Schubert, Rebekah F Seay, Katie K Spain, Holly E Clarke, James K Taylor
Accurate measures of body composition (BC) are essential for performance and health. In addition to accuracy, BC measures should be practical and be minimally invasive to maximize their utility. The purpose of the present study was to compare the day-to-day variability and validity of four common laboratory-based body composition assessments to a criterion four-compartment model. Dual x-ray absorptiometry (DXA), air displacement plethysmography (BP), multi-frequency bioelectrical impedance (MF-BIA) and underwater weighing (UWW) were performed twice in a sample of 32 young men and women...
October 16, 2018: Clinical Physiology and Functional Imaging
Mojgan Firouzbakht, Aram Tirgar, Abbas Ebadi, Hamid Sharif Nia, Tuula Oksanen, Anne Kouvnen, Mohammad Esmaeil Riahi
BACKGROUND: The workplace social capital is one of the important features of clinical work environment that improves the productivity and quality of services and safety through trust and social participation. Evaluation of workplace social capital requires a valid and reliable scale. The short-form workplace social capital questionnaire developed by Kouvonen has long been used to evaluate the workplace social capital. OBJECTIVE: To evaluate the psychometric properties of the Persian version of the questionnaire among a group of female Iranian health care workers...
October 2018: International Journal of Occupational and Environmental Medicine
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