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Shanshan Qin, Lauren Nelson, Lori McLeod, Sonya Eremenco, Stephen Joel Coons
PURPOSE: The US Food and Drug Administration (FDA) 2009 guidance for industry on patient-reported outcome (PRO) measures describes how the Agency evaluates the psychometric properties of measures intended to support medical product labeling claims. An important psychometric property is test-retest reliability. The guidance lists intraclass correlation coefficients (ICCs) and the assessment time period as key considerations for test-retest reliability evaluations. However, the guidance does not provide recommendations regarding ICC computation, nor is there consensus within the measurement literature regarding the most appropriate ICC formula for test-retest reliability assessment...
December 13, 2018: Quality of Life Research
Fenggang Ren, Jing Zhang, Zhongyang Gao, Haoyang Zhu, Xue Chen, Wenyan Liu, Zhao Xue, Weiman Gao, Rongqian Wu, Yi Lv, Liangshuo Hu
The aim of the present study was to investigate the racial disparities in the presentation, treatment and survival time of patients with hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC) between Chinese and other racial groups from the Surveillance, Epidemiology, and End Results (SEER) database between January 1st 2004, and December 31st 2013. Key covariates, including clinical presentation, treatment and survival time, were recorded and compared, demonstrating the racial differences. Kaplan-Meier analysis and Cox regression models were performed to identify these disparities in survival time...
December 2018: Oncology Letters
Laurent Degroote, Ilse De Bourdeaudhuij, Maïté Verloigne, Louise Poppe, Geert Crombez
BACKGROUND: Wearables for monitoring physical activity (PA) are increasingly popular. These devices are not only used by consumers to monitor their own levels of PA but also by researchers to track the behavior of large samples. Consequently, it is important to explore how accurately PA can be tracked via these devices. OBJECTIVES: The aim of this study was, therefore, to investigate convergent validity of 3 Android Wear smartwatches-Polar M600 (Polar Electro Oy, Kempele, Finland), Huawei Watch (Huawei Technologies Co, Ltd, Shenzhen, Guangdong, China), Asus Zenwatch3 (AsusTek Computer Inc, Taipei, Taiwan)-and Fitbit Charge with an ActiGraph accelerometer for measuring steps and moderate to vigorous physical activity (MVPA) on both a day level and 15-min level...
December 13, 2018: JMIR MHealth and UHealth
Caixia Jin, Qingjian Ou, Zongyi Li, Juan Wang, Jieping Zhang, Haibin Tian, Jing-Ying Xu, Furong Gao, Lixia Lu, Guo-Tong Xu
BACKGROUND: Millions of people are affected with retinal diseases that eventually cause blindness, and retinal progenitor cell (RPC) transplantation is a promising therapeutic avenue. However, RPC expansion and the underlying regulation mechanisms remain elusive. METHODS: Adult mouse neural RPCs (mNRPCs) were isolated and amplified with the combination of basic fibroblast growth factor (bFGF) and glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021. The progenitor characteristics were evaluated with RT-PCR, immunocytochemistry (ICC), western blot, flow cytometry, and transcriptome analysis prior to transplantation...
December 13, 2018: Stem Cell Research & Therapy
Uracha Wanich, Dhoungsiri Sayompark, Lynn Riddell, Sara Cicerale, Djin Gie Liem, Mohammadreza Mohebbi, Susie Macfarlane, Russell Keast
Food liking can be directly measured in specialised sensory testing facilities; however, this method is not feasible for large population samples. The aim of the study was to compare a Food Liking Questionnaire (FLQ) against lab-based sensory testing in two countries. The study was conducted with 70 Australian and Thai participants (35 Australian, 35 Thai, mean (SD) age 19 (3.01) years, 51% men). Participants completed a FLQ (consisting of 73 food items Australia, 89 Thai) and then, after tasting the food, rated their liking of a selection of 10 commercially available food items using a nine-point hedonic scale...
December 11, 2018: Nutrients
Andrew T Askow, Jason D Stone, Daniel J Arndts, Adam C King, Shiho Goto, Joseph P Hannon, J Craig Garrison, James M Bothwell, Phil E Esposito, Andrew R Jagim, Margaret T Jones, Will Jennings, Jonathan M Oliver
Given the relationship between explosive-type training and power adaptation, tracking movement velocity has become popular. However, unlike previous variables, tracking velocity necessitates the use of a valid and reliable tool to monitor adaptation over time. Therefore, the primary purpose of this research was to assess the validity and reliability of a commercially-available linear position transducer (LPT). Nine resistance-trained men completed four sessions consisting of a single set of barbell back squat to volitional failure at 75% or 90% one-repetition maximum...
December 10, 2018: Sports
Li-Ye Wang, Shuai Gong, Li-Ping Gao, Li-Xia Hou, Wei He
RATIONALE: Intrahepatic cholangiocarcinoma (ICC) originates from the secondary branch of the bile duct and the intrahepatic bile duct epithelial cells, and is a rare pathological type of primary liver cancer. Recently, apatinib has been successfully used for a variety of malignancies. PATIENT CONCERNS: A 23-year-old female was noted with intermittent right upper abdominal distension, abdominal pain, and vomiting after eating for more than 1 month. The enhanced CT scan revealed multiple intrahepatic lesions, portal vein and right branch tumor emboli were present...
December 2018: Medicine (Baltimore)
Changhong Liu, Desong Ming, Ting-Ting Lei
This report evaluates the performance and species specificity of an immuno-latex chromatography card (ICC) for rapid detection of Candida spp. Double-manipulator single-blind Gram staining smear examination (GSSE) and ICC were used to analyze 354 vaginal discharge specimens (VDS) (including 98 tested as positive by GSSE) from women with suspected candidal vaginitis, simulated specimens with a concentration gradient, and vaginitis causing organism suspensions (0.9% NaCl) of 22 species from nine genera. Limit of detection, semi-quantitative detection performance, total detection performance and species specificity were determined for ICC, and the results were compared with those of the GSSE method...
December 10, 2018: Journal of Microbiological Methods
Gerson M Struik, Frank W de Jongh, Erwin Birnie, Jean-Philippe Pignol, Taco M Klem
PURPOSE: To create a Dutch translated short version of the Breast Cancer Treatment Outcome Scale (BCTOS) and validate it in patients who have completed both breast conserving surgery and adjuvant radiotherapy. METHODS: The BCTOS consists of items comparing the treated with the untreated breast. After forward and backward translation, we tested the BCTOS-12 plus 5 additional items. Two-hundred breast cancer patients treated with breast conserving therapy (BCT) between January 2016 and December 2017, were asked to complete the BCTOS items twice with a 2 week interval...
December 3, 2018: Journal of patient-reported outcomes
Valentin Rausch, Sebastian Wegmann, Michael Hackl, Tim Leschinger, Wolfram F Neiss, Martin Scaal, Lars P Müller, Kilian Wegmann
PURPOSE: Radial head fractures are regularly treated with radial head arthroplasty. To prevent limited motion or pain, the implant's size should match its normal anatomy. Preoperative estimation of the radial head size helps in finding the correct head component. The aim of this study was to measure bony landmarks in proximity to the radial head to estimate the required size of a prosthesis preoperatively. METHODS: Anatomical landmarks on 82 elbows from 41 embalmed specimens (19 male, 22 female) were measured using a digital caliper after removal of the specimens' tissue: the largest and smallest radial head diameter, length of the radius (styloid tip to radial head articular surface), and the length of the ulna (styloid tip to coronoid base)...
December 12, 2018: Surgical and Radiologic Anatomy: SRA
Francis Houde, Sarah Laroche, Veronique Thivierge, Marylie Martel, Marie-Philippe Harvey, Frederique Daigle, Ailin Olivares-Marchant, Louis-David Beaulieu, Guillaume Leonard
Background: Transcranial magnetic stimulation (TMS) is a non-invasive technique that can be used to evaluate cortical function and corticospinal pathway in normal and pathological aging. Yet, the metrologic properties of TMS-related measurements is still limited in the aging population. Objectives: The aim of this cross-sectional study was to document the reliability and smallest detectable change of TMS measurements among community-dwelling seniors. A secondary objective was to test if TMS measurements differ between elders based on lifestyle, medical and socio-demographic factors...
2018: Frontiers in Aging Neuroscience
B Li, J L Song, Y Aierken, Y Chen, J L Zheng, J Y Yang
Whether anatomic resection (AR) achieves better outcomes than nonanatomic resection (NAR) in patients with primary intrahepatic cholangiocarcinoma (ICC) is unclear. Data were retrieved for all consecutive patients who underwent liver resection for primary ICC from January 2007 to July 2017. The prognoses of the patients without direct invasion to contiguous organs or extrahepatic metastasis who underwent AR or NAR were compared. 85 patients underwent AR, and 65 patients underwent NAR. operation time were slightly decreased in the NAR group...
December 12, 2018: Scientific Reports
Yaşar Murat Taş, Gözde Derviş Hakim, Pembe Keskinoğlu, Gökçe Kenar, Handan Yarkan, Berrin Zengin, Gerçek Can, Fatoş Önen, Nurullah Akkoç, Merih Birlik, Mesut Akarsu
BACKGROUND/AIMS: To translate the University of California, Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract (UCLA SCTC GIT) 2.0 questionnaire from English to Turkish and to validate it. MATERIALS AND METHODS: UCLA SCTC GIT 2.0 was translated into Turkish using the translation-retranslation method. The available Turkish GIT 2.0 and the Short Form 36 (SF-36) were administered to 97 Turkish-speaking patients with systemic sclerosis (Ssc). Internal consistency reliability and structural validity were assessed by analyzing the correlations between the UCLA SCTC GIT 2...
December 12, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Sarah Eskreis-Winkler, Giuseppe Corrias, Serena Monti, Junting Zheng, Marinela Capanu, Simone Krebs, Maggie Fung, Scott Reeder, Lorenzo Mannelli
BACKGROUND: Cancer patients often have a history of chemotherapy, putting them at increased risk of liver toxicity and pancytopenia, leading to elevated liver fat and elevated liver iron respectively. T1-in-and-out-of-phase, the conventional MR technique for liver fat assessment, fails to detect elevated liver fat in the presence of concomitantly elevated liver iron. IDEAL-IQ is a more recently introduced MR fat quantification method that corrects for multiple confounding factors, including elevated liver iron...
December 12, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Amador García-Ramos, Alejandro Pérez-Castilla, Slobodan Jaric
This study aimed to compare the reliability and validity of the force-velocity (F-V) relationship parameters obtained from two-point methods differing in the distance between experimental points, and to evaluate the acute change in unloaded jump height after a vertical jump testing procedure based on multiple loads. Totally, 18 men randomly performed two sessions of the squat jump (SJ) and two sessions of the countermovement jump (CMJ) exercises against five external loads (17, 30, 45, 60 and 75 kg). The unloaded jump height was evaluated before and after each testing procedure...
December 12, 2018: Sports Biomechanics
Eliza M Keaney, Machar Reid
The non-invasive measurement of movement through sensor technologies is common in elite sport, yet only recently become possible in tennis. This study validated two commercial tennis racquet sensors compared to gold standards in VICON and expert notational analysis. One national-level male tennis player hit 24 shots (9 forehands and 9 backhands, hit with heavy topspin, flat and slice; 6 serves) using a Babolat Play racket with a Zepp sensor. Measures of shot type, impact location and racket speed were compared against those captured by a 500-Hz 12 camera VICON system...
December 12, 2018: Sports Biomechanics
Carl A J Puylaert, Charlotte J Tutein Nolthenius, Jeroen A W Tielbeek, Jesica C Makanyanga, Manuel Rodriguez-Justo, Lodewijk A A Brosens, C Yung Nio, Douglas A Pendsé, Cyriel Y Ponsioen, Frans M Vos, Stuart A Taylor, Jaap Stoker
OBJECTIVE: The purpose of this study was to evaluate four previously validated MRI activity scoring systems for diagnosis and grading of Crohn disease (CD) in the terminal ileum against an endoscopic and histopathologic reference standard. SUBJECTS AND METHODS: Ethics approval and written informed consent were obtained. Subjects with known or suspected CD were prospectively recruited between December 2011 and August 2014. Each patient underwent MRI and ileocolonoscopy with terminal ileum biopsies...
December 12, 2018: AJR. American Journal of Roentgenology
Alberto Pena-Gayo, Víctor Manuel González-Chordá, Águeda Cervera-Gasch, Desirée Mena-Tudela
OBJECTIVES: the current study aimed to adapt the Self-Transcendence Scale (STS) to the Spanish context and analyse its psychometric properties. METHOD: the STS was administered to a general Spanish population of adults (i.e., older than 20 years; n = 116) through an online platform. The Psychological Well-Being (PWB) and the Functional Assessment of Chronic Illness Therapy - Spiritual Well-being - modified version for healthy people (FACIT-Sp-Non-Illness) scales were also applied in two moments separated by an interval of 15 days...
December 10, 2018: Revista Latino-americana de Enfermagem
Francisco Victor Costa Parente, Eder Alencar Moura, José Alexandre de Macêdo Dos Santos, Marcos Venício Alves Lima
BACKGROUND: Though strongly suggestive of metastasis, focal lesions on liver scans of oncological patients require histological confirmation for the prescription of adequate treatment. OBJECTIVE: To evaluate the safety and efficacy of US-guided percutaneous core liver biopsy. METHODS: Descriptive, cross-sectional study based on secondary data from 171 patients submitted to US-guided percutaneous core liver biopsy at the diagnostic radiology service of the Ceará Cancer Institute (ICC, Brazil) between February 2010 and March 2015...
July 2018: Arquivos de Gastroenterologia
Vasiliki Koretsi, Constanze Kirschbauer, Peter Proff, Christian Kirschneck
OBJECTIVE: To investigate if orthodontic model analysis with a digital caliper can be interchangeably performed between plaster and printed dental models. MATERIALS AND METHODS: Forty-eight plaster models were digitized with orthoX®scan (DENTAURUM) and 48 counterparts were printed with Objet30 Dental Prime (Stratasys). One examiner performed five repeated orthodontic model analyses (41 outcomes) with a digital caliper in each plaster and the corresponding printed model and was externally validated by a second examiner...
December 11, 2018: Clinical Oral Investigations
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