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Pineal tumors

Nadir Koçak, Hüseyin Dönmez, İbrahim Halil Yildirim
Melatonin is a hormone of the pineal gland that has a wide range of biological effects such as antioxidant, anti-inflammatory, and anti-tumor activity. Previous studies have shown that melatonin also affects survival, proliferation, and apoptosis of the cells. In this study, we investigated the effect of melatonin on apoptosis, self-renewal, and differentiation. For this purpose, MCF-7 and HEK293 cells were subjected to melatonin treatment. Expression of genes related to apoptosis (Bax and Bcl2) and self-renewal and differentiation (Oct4, Sox2, and Nanog) analyzed after the sorting of cancer stem cells from MCF-7 cells...
September 30, 2018: Cellular and Molecular Biology
Mattias Belting, Anna Bång-Rudenstam, Elisabet Englund, Torsten Pietsch
No abstract text is available yet for this article.
October 5, 2018: Neuro-oncology
Joham Choque-Velasquez, Juha Hernesniemi
Background: In this video abstract, we present a one burr-hole craniotomy for the posterior interhemispheric approach developed in Helsinki Neurosurgery to access posteriorly the medial surface of cerebral hemispheres, falx cerebri, and deep midline cerebrovascular structures. Therefore, preoperative imaging is essential to achieve an optimal operative corridor for a safest and more effcient approach. Case Description: The patient with a papillary tumor of the pineal region is placed in sitting position...
2018: Surgical Neurology International
Reza Akhavan-Sigari, Hesam Abdolhoseinpour, Werner Meyer, Veit Rohde, Walter Schulz-Schaeffer
Carcinosarcomas are tumors comprising part adenocarcinoma and part sarcoma; the presence of carcinosarcoma in the head-and-neck region is very rare. These tumors are typically highly aggressive (G3) and arise most frequently from the salivary gland. Here, we present a case report on a brain metastasis as the primary manifestation of a carcinosarcoma. Magnetic resonance imaging showed a tumor of the pineal region with infiltration of the brainstem and the corpus. The staging following the histopathological diagnosis revealed the origin of the tumor in the left parotid gland...
July 2018: Asian Journal of Neurosurgery
Kaleigh Fetcko, Mahua Dey
Importance: Primary central nervous system (CNS) germ cell tumors (GCT) are a heterogeneous group of tumors that are still poorly understood. In North America, GCTs comprise approximately 1% of primary brain tumors in pediatric and young adult patients. GCTs can occur as pure or mixed subtypes; they are divided into germinomas, which are the most common subtype, and non-germinomatous germ cell tumors (NGGCTs), which consist of approximately one-third of GCTs and include teratomas, embryonal carcinomas, choriocarcinomas, and yolk sac tumors...
March 2018: Medical Research Archives
Yasuo Aihara, Sinichiro Watanabe, Kosaku Amano, Kana Komatsu, Kentaro Chiba, Kosuke Imanaka, Tomokatsu Hori, Takashi Ohba, Hitoshi Dairoku, Yoshikazu Okada, Osami Kubo, Takakazu Kawamata
OBJECTIVE: Placental alkaline phosphatase (PLAP) in CSF can provide a very high diagnostic value in cases of intracranial germ cell tumors (GCTs), especially in pure germinomas, to the level of not requiring histological confirmation. Unlike other tumor markers, reliable data analysis with respect to the diagnostic value of PLAP serum or CSF levels has not been available until now. This is the first systematic and comprehensive study examining the diagnostic value of CSF PLAP in patients with intracranial GCTs...
September 28, 2018: Journal of Neurosurgery
Olga Krestinina, Roman Fadeev, Alexey Lomovsky, Yulia Baburina, Margarita Kobyakova, Vladimir Akatov
Melatonin is produced by the pineal gland. It can be regarded as an anticancer agent and used for combined therapy, owing to its oncostatic, antioxidant, and immunoregulatory activities. Retinoic acid is widely used for the treatment of acute promyelocytic leukemia; however, it has adverse effects on the human organism. We investigated the effect of melatonin and reduced concentrations of retinoic acid on the activation of proliferation in acute promyelocytic leukemiaon a cell model HL-60. The combined effect of these compounds leads to a reduction in the number of cells by 70% and the index of mitotic activity by 64%...
September 21, 2018: International Journal of Molecular Sciences
Érica Lui Reinhardt, Pedro Augusto Carlos Magno Fernandes, Regina P Markus, Frida Marina Fischer
Shift work is unavoidable in modern societies, but at the same time disrupts biological rhythms and contributes to social distress and disturbance of sleep, health and well-being of shift workers. Shift work has been associated with some chronic diseases in which a chronic inflammatory condition may play a role. However, few studies investigating the association of cytokine and other inflammation markers with shift workers have been published in recent years. In this study we evaluated the effects of permanent night work on the production of tumor necrosis factor (TNF), interleukin-1β (IL-1β), IL-6 and melatonin in saliva...
September 19, 2018: Chronobiology International
Joham Choque-Velasquez, Rahul Raj, Juha Hernesniemi
Background: In this video abstract, we present a one burr-hole craniotomy for the standard supracerebellar infratentorial (SCIT) paramedian approach developed in Helsinki Neurosurgery for the microsurgical management of pineal region lesions, tentorial meningiomas, as well as arteriovenous malformations, aneurysms, and intrinsic tumors of the superior surface of the cerebellum. In this regard, the use of praying sitting position in Helsinki Neurosurgery, which is a more ergonomic variant of the classic sitting position, offers several advantages such as lower intracranial pressure, good venous outflow, gravitational retraction, and straight anatomical orientation...
2018: Surgical Neurology International
Marcin Braun, Bartłomiej Tomasik, Michał Bieńkowski, Karol Wiśniewski, Dorota-Jesionek Kupnicka, Dariusz Jaskólski, Wielisław Papierz, Jacek Fijuth, Radzislaw Kordek
BACKGROUND: Papillary tumors of the pineal region (PTPRs) are malignant WHO grade II/III tumors, however they may perfectly mimic benign tumors, e.g. pineocytomas (WHO grade I). CASE DESCRIPTION: We present a case of a 28-year-old male with a 35mm tumor of the pineal region. Considering the typical radiological and pathological presentation, the tumor was firstly diagnosed as pineocytoma. However, despite first total resection the tumor recurred after 7 years. The recurrent neoplasm was composed mainly of papillary structures with low-grade atypical cells positive for CKAE1/AE3 and CK18...
August 27, 2018: World Neurosurgery
Amanda R Clark, David Calligaris, Michael S Regan, Daniel Pomeranz Krummel, Jeffrey N Agar, Laura Kallay, Tobey MacDonald, Matthew Schniederjan, Sandro Santagata, Scott L Pomeroy, Nathalie Y R Agar, Soma Sengupta
PURPOSE: Medulloblastoma, the most common primary pediatric malignant brain tumor, originates in the posterior fossa of the brain. Pineoblastoma, which originates within the pineal gland, is a rarer malignancy that also presents in the pediatric population. Medulloblastoma and pineoblastoma exhibit overlapping clinical features and have similar histopathological characteristics. Histopathological similarities confound rapid diagnoses of these two tumor types. We have conducted a pilot feasibility study analyzing the molecular profile of archived frozen human tumor specimens using mass spectrometry imaging (MSI) to identify potential biomarkers capable of classifying and distinguishing between medulloblastoma and pineoblastoma...
August 20, 2018: Journal of Neuro-oncology
Kannika Permpoonputtana, Patlada Tangweerasing, Sujira Mukda, Parichart Boontem, Chutikorn Nopparat, Piyarat Govitrapong
Aging is often accompanied by a decline in cognitive function in conjunction with a variety of neurobiological changes, including neuroinflammation. Melatonin is a key endogenous indoleamine secreted by the pineal gland that plays a crucial role in the regulation of circadian rhythms, is a potent free radical scavenger, has anti-inflammatory activity and serves numerous other functions. However, the role of melatonin in sterile inflammation in the brain has not been fully investigated. In the present study, we investigated the neuroinflammation status in aged mouse brains...
2018: EXCLI journal
Akiko Miki, Masashi Fujihara, Akiko Yoshida, Makoto Nakamura, Atsushi Azumi
Purpose: To report a rare case of bilateral periphlebitis associated with a pineal germinoma. Observations: A 17-year-old male teenager presented at a local clinic complaining of blurred vision in both eyes. The treating physician identified bilateral uveitis, and prescribed the patient with a local steroid treatment. However, the inflammatory findings did not improve with the treatment, and the patient was referred to our hospital for further examination. At the first visit, his best-corrected visual acuities were 0...
September 2018: American Journal of Ophthalmology Case Reports
Jia Wei, Hufei Qian, Yu Liu, Jiangang Liu, Rui Zhao, Xiao Yang, Xiangdong Zhu, Ruoping Chen, Xingdong Zhang
This work aimed at investigating the possibility and effectiveness of osteoinductive calcium phosphate (CaP) ceramics to close the drilled skull holes and prevent the postoperative cerebrospinal fluid (CSF) leaking in children's endoscopic neurosurgery. Five children patients (four boys and one girl, 3- to 8-years old) underwent the surgery, in which the endoscopic third ventriculostomy (ETV) was operated in four cases of hydrocephalus, and biopsy and ETV were both performed in one case of pineal tumor. The drilled skull holes were filled with the commercial osteoinductive CaP ceramics...
August 2018: Regenerative Biomaterials
Harshad Patil, Nitin Garg
Teratomas are germ cell tumors commonly composed of cell types derived from all of the three germ layers. Intracerebral teratomas typically present in midline or paraxial lesions located in the pituitary stalk or the pineal region. Teratoma in posterior fossa is a rare entity. We reported a case of midline posterior fossa mature teratoma in a 3-month-old child.
April 2018: Journal of Pediatric Neurosciences
Fayçal Ben Bouallègue, Fabien Vauchot, Nicolas Menjot de Champfleur, Denis Mariano-Goulart
A 49-year-old woman presented to the emergency room with subacute paraparesis associated with bilateral cervicobrachial neuralgia. Brain and spine MRI revealed a heterogeneous hypervascular pineal tumor and a multifocal thoracolumbar intradural-extramedullary infiltrate with signs of medullary compression. C7-T2 laminectomy was performed on the same day for medullary decompression, allowing for partial lesion excision. Histological examination was in favor of a poorly differentiated anaplastic ependymoma. Two weeks later, FDG-PET showed markedly increased uptake in the pineal mass and significant hypermetabolism of the spinal metastases...
September 2018: Clinical Nuclear Medicine
Matija Snuderl, Kasthuri Kannan, Elke Pfaff, Shiyang Wang, James M Stafford, Jonathan Serrano, Adriana Heguy, Karina Ray, Arline Faustin, Olga Aminova, Igor Dolgalev, Stacie L Stapleton, David Zagzag, Luis Chiriboga, Sharon L Gardner, Jeffrey H Wisoff, John G Golfinos, David Capper, Volker Hovestadt, Marc K Rosenblum, Dimitris G Placantonakis, Sarah E LeBoeuf, Thales Y Papagiannakopoulos, Lukas Chavez, Sama Ahsan, Charles G Eberhart, Stefan M Pfister, David T W Jones, Matthias A Karajannis
Pineoblastoma is a rare and highly aggressive brain cancer of childhood, histologically belonging to the spectrum of primitive neuroectodermal tumors. Patients with germline mutations in DICER1, a ribonuclease involved in microRNA processing, have increased risk of pineoblastoma, but genetic drivers of sporadic pineoblastoma remain unknown. Here, we analyzed pediatric and adult pineoblastoma samples (n = 23) using a combination of genome-wide DNA methylation profiling and whole-exome sequencing or whole-genome sequencing...
July 20, 2018: Nature Communications
Toshiaki Bando, Yasushi Ueno, Narihide Shinoda, Yukihiro Imai, Kazuhito Ichikawa, Yoji Kuramoto, Takahiro Kuroyama, Daisuke Shimo, Kazuyuki Mikami, Shinya Hori, Masato Matsumoto, Osamu Hirai
Pineal parenchymal tumor of intermediate differentiation (PPTID) is rare. The WHO first classified PPTID in 2000 as a pineal parenchymal tumor (PPT) with an intermediate prognosis between pineocytoma (PC) and pineoblastoma (PB). It is considered an intermediate-grade tumor and divided into WHO grade II or III. The number of available reports about PPTID is presently limited, and the appropriate management for this tumor has not yet been determined. The authors report a rare case of PC in a 63-year-old woman who presented with lower-extremity weakness and gait disturbance...
July 20, 2018: Journal of Neurosurgery
Jianping Song, Wei Hua, Zhiguang Pan, Wei Zhu
Pineal tumor that extends into the posterior portion of the third ventricle is extremely deep-seated and surgically challenging. Various microscopic approaches have been introduced to acquire access to the posterior third ventricle, but still the exposure and visualization are relatively unfavorable. However, recently the application of high-definition endoscope gave neurosurgeons a much more magnified and clearer view of anatomy around the pineal region and third ventricle. The widely used supracerebellar infratentorial approach has been proven to offer a sufficient surgical corridor for fully endoscopic surgery for pineal tumor...
July 13, 2018: Operative Neurosurgery (Hagerstown, Md.)
Jaime Gerardo Torres-Corzo, Mario Alberto Islas-Aguilar, Christian Daniel Cerecedo-López
BACKGROUND: Ventricular tumors (VTs) represent approximately 10% of intracranial lesions and are associated with hydrocephalus in 73.9%-100% of patients. We present our experience using flexible neuroendoscopy as a diagnostic and hydrocephalus-related treatment strategy for paraventricular and intraventricular tumors. METHODS: This retrospective cohort included 27 pediatric and 21 adult patients with paraventricular or intraventricular tumors treated with flexible neuroendoscopy...
October 2018: World Neurosurgery
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