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Pineal tumors

Akiko Miki, Masashi Fujihara, Akiko Yoshida, Makoto Nakamura, Atsushi Azumi
Purpose: To report a rare case of bilateral periphlebitis associated with a pineal germinoma. Observations: A 17-year-old male teenager presented at a local clinic complaining of blurred vision in both eyes. The treating physician identified bilateral uveitis, and prescribed the patient with a local steroid treatment. However, the inflammatory findings did not improve with the treatment, and the patient was referred to our hospital for further examination. At the first visit, his best-corrected visual acuities were 0...
September 2018: American Journal of Ophthalmology Case Reports
Jia Wei, Hufei Qian, Yu Liu, Jiangang Liu, Rui Zhao, Xiao Yang, Xiangdong Zhu, Ruoping Chen, Xingdong Zhang
This work aimed at investigating the possibility and effectiveness of osteoinductive calcium phosphate (CaP) ceramics to close the drilled skull holes and prevent the postoperative cerebrospinal fluid (CSF) leaking in children's endoscopic neurosurgery. Five children patients (four boys and one girl, 3- to 8-years old) underwent the surgery, in which the endoscopic third ventriculostomy (ETV) was operated in four cases of hydrocephalus, and biopsy and ETV were both performed in one case of pineal tumor. The drilled skull holes were filled with the commercial osteoinductive CaP ceramics...
August 2018: Regenerative Biomaterials
Harshad Patil, Nitin Garg
Teratomas are germ cell tumors commonly composed of cell types derived from all of the three germ layers. Intracerebral teratomas typically present in midline or paraxial lesions located in the pituitary stalk or the pineal region. Teratoma in posterior fossa is a rare entity. We reported a case of midline posterior fossa mature teratoma in a 3-month-old child.
April 2018: Journal of Pediatric Neurosciences
Fayçal Ben Bouallègue, Fabien Vauchot, Nicolas Menjot de Champfleur, Denis Mariano-Goulart
A 49-year-old woman presented to the emergency room with subacute paraparesis associated with bilateral cervicobrachial neuralgia. Brain and spine MRI revealed a heterogeneous hypervascular pineal tumor and a multifocal thoracolumbar intradural-extramedullary infiltrate with signs of medullary compression. C7-T2 laminectomy was performed on the same day for medullary decompression, allowing for partial lesion excision. Histological examination was in favor of a poorly differentiated anaplastic ependymoma. Two weeks later, FDG-PET showed markedly increased uptake in the pineal mass and significant hypermetabolism of the spinal metastases...
September 2018: Clinical Nuclear Medicine
Matija Snuderl, Kasthuri Kannan, Elke Pfaff, Shiyang Wang, James M Stafford, Jonathan Serrano, Adriana Heguy, Karina Ray, Arline Faustin, Olga Aminova, Igor Dolgalev, Stacie L Stapleton, David Zagzag, Luis Chiriboga, Sharon L Gardner, Jeffrey H Wisoff, John G Golfinos, David Capper, Volker Hovestadt, Marc K Rosenblum, Dimitris G Placantonakis, Sarah E LeBoeuf, Thales Y Papagiannakopoulos, Lukas Chavez, Sama Ahsan, Charles G Eberhart, Stefan M Pfister, David T W Jones, Matthias A Karajannis
Pineoblastoma is a rare and highly aggressive brain cancer of childhood, histologically belonging to the spectrum of primitive neuroectodermal tumors. Patients with germline mutations in DICER1, a ribonuclease involved in microRNA processing, have increased risk of pineoblastoma, but genetic drivers of sporadic pineoblastoma remain unknown. Here, we analyzed pediatric and adult pineoblastoma samples (n = 23) using a combination of genome-wide DNA methylation profiling and whole-exome sequencing or whole-genome sequencing...
July 20, 2018: Nature Communications
Toshiaki Bando, Yasushi Ueno, Narihide Shinoda, Yukihiro Imai, Kazuhito Ichikawa, Yoji Kuramoto, Takahiro Kuroyama, Daisuke Shimo, Kazuyuki Mikami, Shinya Hori, Masato Matsumoto, Osamu Hirai
Pineal parenchymal tumor of intermediate differentiation (PPTID) is rare. The WHO first classified PPTID in 2000 as a pineal parenchymal tumor (PPT) with an intermediate prognosis between pineocytoma (PC) and pineoblastoma (PB). It is considered an intermediate-grade tumor and divided into WHO grade II or III. The number of available reports about PPTID is presently limited, and the appropriate management for this tumor has not yet been determined. The authors report a rare case of PC in a 63-year-old woman who presented with lower-extremity weakness and gait disturbance...
July 20, 2018: Journal of Neurosurgery
Jianping Song, Wei Hua, Zhiguang Pan, Wei Zhu
Pineal tumor that extends into the posterior portion of the third ventricle is extremely deep-seated and surgically challenging. Various microscopic approaches have been introduced to acquire access to the posterior third ventricle, but still the exposure and visualization are relatively unfavorable. However, recently the application of high-definition endoscope gave neurosurgeons a much more magnified and clearer view of anatomy around the pineal region and third ventricle. The widely used supracerebellar infratentorial approach has been proven to offer a sufficient surgical corridor for fully endoscopic surgery for pineal tumor...
July 13, 2018: Operative Neurosurgery (Hagerstown, Md.)
Jaime Gerardo Torres-Corzo, Mario Alberto Islas-Aguilar, Christian Daniel Cerecedo-López
BACKGROUND: Ventricular tumors represent approximately 10% of intracranial lesions and are associated with hydrocephalus in 73.9%-100% of patients. We present our experience using flexible neuroendoscopy as a diagnostic and hydrocephalus related treatment strategy for paraventricular and intraventricular tumors. METHODS: Twenty-seven pediatric and twenty-one adult patients with paraventricular or intraventricular tumors, treated with flexible neuroendoscopy were included in this retrospective cohort...
July 12, 2018: World Neurosurgery
Chloé Bost, Eve Chanson, Géraldine Picard, David Meyronet, Marie-Eve Mayeur, François Ducray, Veronique Rogemond, Dimitri Psimaras, Jean-Christophe Antoine, Jean-Yves Delattre, Virginie Desestret, Jerome Honnorat
OBJECTIVE: The aim of this study was to describe specificities of patients with NMDA receptor antibody (NMDAR-Ab) encephalitis associated with a malignant tumor. METHODS: Retrospective observational study of 252 patients with NMDAR-Ab encephalitis of the French Paraneoplastic Neurological Syndrome Reference Center. Patients were classified in three groups: (1) non-malignant ovarian teratomas, (2) malignant ovarian teratomas (immature), and (3) other malignant tumors...
July 12, 2018: Journal of Neurology
Randy S D'Amico, George Zanazzi, Peter Wu, Peter Canoll, Jeffrey N Bruce
INTRODUCTION: Pineal region glioblastomas (GBM) are very rare, with approximately 46 cases described in the literature. The epidemiology, pathogenesis, and treatment of these lesions are poorly characterized. METHODS: We identified all cases of pineal region GBM treated surgically at our institution between 1990 and 2017. Demographic and clinical follow-up data were extracted from the medical records for all cases. Pathology was reviewed and classified according to 2016 World Health Organization (WHO) criteria...
July 10, 2018: Journal of Neuro-oncology
Bruno Niemeyer de Freitas Ribeiro, Bernardo Carvalho Muniz, Nina Ventura, Emerson Leandro Gasparetto, Edson Marchiori
No abstract text is available yet for this article.
May 2018: Radiologia Brasileira
Jéssica H M Marques, André L Mota, Jessica G Oliveira, Jéssica Z Lacerda, Júlia P Stefani, Lívia C Ferreira, Tialfi B Castro, Andrés F Aristizábal-Pachón, Debora A P C Zuccari
AIMS: Breast cancer represents the second most prevalent tumor-related cause of death among women. Although studies have already been published regarding the association between breast tumors and miRNAs, this field remains unclear. MicroRNAs (miRNAs) are defined as non-coding RNA molecules, and are known to be involved in cell pathways through the regulation of gene expression. Melatonin can regulate miRNAs and genes related with angiogenesis. This hormone is produced naturally by the pineal gland and presents several antitumor effects...
July 7, 2018: Life Sciences
N K Serova, E I Butenko, A N Konovalov, N N Grigor'eva, D I Pitskhelauri, I T Abramov, G V Danilov
The most common clinical manifestations of space-occupying lesions of the midbrain and pineal region are oculomotor and pupil disorders and ophthalmoscopic signs of intracranial hypertension. PURPOSE: To identify patterns of neuro-ophthalmic symptoms before and after surgical treatment in patients with space-occupying lesions of the midbrain and pineal region. MATERIAL AND METHODS: We analyzed neurological symptoms in 231 patients with space-occupying lesions of the midbrain and pineal region before and after surgical treatment...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Lourdes M DelRosso, Kenneth Martin, Oliviero Bruni, Raffaele Ferri
INTRODUCTION: For several years, pineal cysts have been considered an incidental finding on brain MRI's even though research and case reports have shown a possible association of pineal cysts with headaches and sleep disturbances. This pilot study aims to evaluate sleep disorders in school-age children with an incidental pineal cyst in an otherwise normal brain MRI. METHOD: Children aged 6-12 years, who were referred for evaluation of headaches, tics, or syncope, and had an incidental pineal cyst on an otherwise normal brain MRI were included and compared to a control group of children with the same referral reasons but with a normal MRI and to a cohort of normal controls...
August 2018: Sleep Medicine
Joham Choque-Velasquez, Roberto Colasanti, Julio Resendiz-Nieves, Behnam Rezai Jahromi, Olli Tynninen, Juhani Collan, Mika Niemelä, Juha Hernesniemi
The papillary tumor of the pineal region (PTPR) is a rare grade II-III pineal lesion with peculiar histologic and immunohistochemical features. These tumors mostly occur in adults, rarely in children (19 cases reported up to now). We present a 3-year-old boy who was re-operated for a recurrent PTPR (grade II). The gross total resection of the lesion, through an occipital interhemispheric approach in sitting position, was followed by adjuvant radiochemotherapy. Histological examination revealed tumor progression (grade III), and the MIB-1 proliferation index was higher than 25%...
June 12, 2018: World Neurosurgery
Mohammad Kaif, Azfar Neyaz, Saumya Shukla, Nuzhat Husain
A malignant component in an epidermoid cyst is rare. We report an exceptionally rare case of a malignant melanoma arising in an epidermoid cyst located in the cerebellopontine (CP) angle. A 26-year-old woman presented with headache, vomiting, ataxia and difficulty in swallowing over the previous 3 months. The radiological finding suggested an epidermoid cyst and the lesion was excised. The histopathology confirmed a CP angle epidermoid cyst. Within 1 month of discharge, she developed hydrocephalus for which a ventriculo-peritoneal shunt was performed...
June 6, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Robert T Dauchy, Melissa A Wren-Dail, Lynell M Dupepe, Steven M Hill, Shulin Xiang, Muralidharan Anbalagan, Victoria P Belancio, Erin M Dauchy, David E Blask
Liver cancer is the second leading cause of cancer death worldwide. Metabolic pathways within the liver and liver cancersare highly regulated by the central circadian clock in the suprachiasmatic nuclei (SCN). Daily light and dark cycles regulate the SCN-driven pineal production of the circadian anticancer hormone melatonin and temporally coordinate circadianrhythms of metabolism and physiology in mammals. In previous studies, we demonstrated that melatonin suppresses linoleicacid metabolism and the Warburg effect (aerobic glycolysis)in human breast cancer xenografts and that blue-enriched light(465-485 nm) from light-emitting diode lighting at daytime (bLAD) amplifies nighttime circadian melatonin levels in ratsby 7-fold over cool white fluorescent (CWF) lighting...
June 6, 2018: Comparative Medicine
Aldo Giudice, Anna Crispo, Maria Grimaldi, Andrea Polo, Sabrina Bimonte, Mario Capunzo, Alfonso Amore, Giovanni D'Arena, Pellegrino Cerino, Alfredo Budillon, Gerardo Botti, Susan Costantini, Maurizio Montella
In mammals, a master clock is located within the suprachiasmatic nucleus (SCN) of the hypothalamus, a region that receives input from the retina that is transmitted by the retinohypothalamic tract. The SCN controls the nocturnal synthesis of melatonin by the pineal gland that can influence the activity of the clock's genes and be involved in the inhibition of cancer development. On the other hand, in the literature, some papers highlight that artificial light exposure at night (LAN)-induced circadian disruptions promote cancer...
May 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mahmoud Abbassy, Khaled Aref, Ahmed Farhoud, Anwar Hekal
BACKGROUND: Tumors within the pineal region represent 1.5 to 8.5% of the pediatric brain tumors and 1.2% of all brain tumors. A management algorithm has been proposed in several publications. The algorithm includes endoscopic third ventriculostomy (ETV) and biopsy in cases presenting with hydrocephalus. In this series, we are presenting the efficacy of a single-trajectory approach for both ETV and biopsy. METHODS: Eleven cases were admitted to Alexandria main university hospital from 2013 to 2016 presenting with pineal region tumors and hydrocephalus...
July 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Tialfi Bergamin de Castro, Newton Antônio Bordin-Junior, Eduardo Alves de Almeida, Debora Aparecida Pires de Campos Zuccari
PURPOSE: Changes in the circadian rhythm may contribute to the development of cancer and are correlated with the high risk of breast cancer (BC) in night workers. Melatonin is a hormone synthesized by the pineal gland at night in the absence of light. Levels of melatonin and the metabolite of oxidative metabolism AFMK (acetyl-N-formyl-5-methoxykynurenamine), are suggested as potential biomarkers of BC risk. The aims of this study were to evaluate levels of melatonin and AFMK in women recently diagnosed with BC, women under adjuvant chemotherapy, and night-shift nurses, and compare them with healthy women to evaluate the relation of these compounds with BC risk...
May 24, 2018: Endocrine
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