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Erectile AND Dysfunction

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https://www.readbyqxmd.com/read/30109146/nocturnal-penile-erections-a-retrospective-study-of-the-role-of-rigiscan-in-predicting-the-response-to-sildenafil-in-erectile-dysfunction-patients
#1
Samir M Elhanbly, Mamdouh M Abdel-Gawad, Ayman A Elkholy, Ahmed F State
Sildenafil enhances the nitric oxide-cGMP pathway of erection, which is claimed to have a role in nocturnal penile tumescence and rigidity (NPTR). This study aimed to find whether RigiScan can predict the response to sildenafil among erectile dysfunction (ED) patients and to find which RigiScan parameter produces the best prediction. Medical records of 172 ED patients were revised regarding their full sexual history, standard andrology examination, NPTR monitoring by the RigiScan device, and the degree of response to sildenafil...
November 2018: Journal of Advanced Research
https://www.readbyqxmd.com/read/30108337/low-intensity-shockwave-therapy-for-erectile-dysfunction-in-kidney-transplant-recipients-a-prospective-randomized-double-blinded-sham-controlled-study-with-evaluation-by-penile-doppler-ultrasonography
#2
Kleiton G R Yamaçake, Felipe Carneiro, Jose Cury, Rodolfo Lourenço, Peter C Françolin, Affonso C Piovesan, Miguel Srougi, Willian C Nahas, Ioannis M Antonopoulos
OBJECTIVES: To study the efficacy of Low intensity Extracorporeal Shockwave Therapy (Li- ESWT) for the treatment of erectile dysfunction (ED) in kidney transplanted men. METHODS: Twenty men (mean age = 53.7 years) were selected. This was a double-blinded, prospective, randomized, sham-controlled trial. The ESWT protocol was based in a 2 treatment sessions per week for 3 weeks. The sham treatment was performed using the same device replacing the effective probe for one that emits zero energy...
August 14, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/30106605/pharmacotherapy-for-erectile-dysfunction-in-diabetic-males
#3
Ahmed I El-Sakka
Numerous studies have highlighted the intimate association between erectile dysfunction (ED) and diabetes mellitus (DM). However, the true pathogenesis of ED among diabetic men has not yet been fully discovered. The treatment of ED in diabetic patients remains an interesting area of research. The last two decades have witnessed phenomenal advances in the management of ED with the efficacy of pharmacotherapy for ED in diabetic patients encouraging, especially with introduction of innovative conservative tools for treatment...
August 14, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/30105747/sex-hormones-erectile-dysfunction-and-psoriasis-a-bad-friendship
#4
Abd El Aziz I Eltaweel, Amany I Mustafa, Ola S El-Shimi, Fatma A Algaod
BACKGROUND: Sex hormones may play a major role in psoriasis pathogenesis due to their biological and immunological effects on skin. Psoriasis also has a significant impact on patients' sexual function and thus their quality of life. AIM: In the present study, we investigated serum sex hormones and erectile function in male psoriasis patients compared with healthy controls and correlated these findings with various disease parameters. METHODS: Serum total testosterone and estradiol were measured by an ELISA technique in 50 male patients with psoriasis and 30 healthy controls...
August 13, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/30104862/finasteride-nano-transferosomal-gel-formula-for-management-of-androgenetic-alopecia-ex-vivo-investigational-approach
#5
Osama Aa Ahmed, Waleed Y Rizq
Introduction: Finasteride (FIN) is known as type II 5α-reductase inhibitor, which has been approved for the treatment and prevention of androgenetic alopecia. Administration of FIN by oral route has led to undesirable systemic side effects that include mood disturbance, gynecomastia, decreased libido, erectile dysfunction, and ejaculation disorder. The aim was to improve FIN delivery through skin layers and hair follicles that could possibly reduce its major side effects resulting from long-term oral administration for the treatment and prevention of male pattern baldness...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/30104671/prevalence-and-correlates-of-erectile-dysfunction-in-type-2-diabetic-men-a-population-based-cross-sectional-study-in-chinese-men
#6
Yawei Xu, Yuanyuan Zhang, Yongjiao Yang, Li Liu, Yegang Chen, Xiaoqiang Liu
The aim of this study was to estimate the prevalence and correlates of erectile dysfunction (ED) in a sample of Chinese type 2 diabetic men. Between October 2016 and April 2017, male patients with type 2 diabetes mellitus treated in our diabetes outpatient clinic were recruited in this study. The participants were asked to complete a short version of the International Index of Erectile Function (IIEF-5), which was a validated and self-administered questionnaire for the diagnosis and grading of ED severity. All patients screened for erectile function also underwent detailed physical examination, and interviewed for demographic and medical history...
August 13, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/30104298/burden-of-urological-complications-in-men-and-women-with-long-standing-type-1-diabetes-in-the-diabetes-control-and-complication-trial-epidemiology-of-diabetes-interventions-and-complications-cohort
#7
Hunter Wessells, Barbara H Braffett, Sarah K Holt, Alan M Jacobson, John W Kusek, Catherine Cowie, Rodney L Dunn, Aruna V Sarma
OBJECTIVE: Type 1 diabetes has been associated with high rates of urinary and sexual problems, but the cumulative burden and overlap of these complications are unknown. We sought to determine prevalence of urological complications in persons with type 1 diabetes, associations with clinical and diabetes-related factors, and rates of emergence, persistence, and remission. RESEARCH DESIGN AND METHODS: This ancillary longitudinal study among participants in the Diabetes Control and Complications Trial and observational follow-up study Epidemiology of Diabetes Interventions and Complications (652 women and 713 men) was conducted in 2003 and 2010/2011...
August 13, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30101547/comprehensive-insight-into-functional-interaction-between-gnb3-c825t-and-enos-t-786c-g894t-gene-polymorphisms-and-association-with-susceptibility-to-diabetic-erectile-dysfunction
#8
M R Ben Khedher, M Abid, K Jamoussi, M Hammami
BACKGROUND: No study has assessed the possible involvement of endothelial nitric oxide synthase (eNOS) T-786C and G894T and G-protein β3 subunit (GNB3) C825T polymorphisms with susceptibility to diabetic vasculogenic erectile dysfunction (VED) in North African subjects. OBJECTIVES: Our aim was to evaluate the interaction and association between these gene polymorphisms and this disorder. MATERIALS AND METHODS: A total of 164 type 2 diabetes patients with VED diagnosed with penile color Doppler ultrasonography and 148 age-matched healthy volunteers were genotyped for the rs1799983 (G894T) and rs2070744 (T-786C) of the eNOS gene and the rs5443 (C825T) of the GNB3 gene using the PCR-RFLP method...
August 12, 2018: Andrology
https://www.readbyqxmd.com/read/30097885/prostate-cancer-in-primary-care
#9
REVIEW
Samuel W D Merriel, Garth Funston, Willie Hamilton
Prostate cancer is a common malignancy seen worldwide. The incidence has risen in recent decades, mainly fuelled by more widespread use of prostate-specific antigen (PSA) testing, although prostate cancer mortality rates have remained relatively static over that time period. A man's risk of prostate cancer is affected by his age and family history of the disease. Men with prostate cancer generally present symptomatically in primary care settings, although some diagnoses are made in asymptomatic men undergoing opportunistic PSA screening...
August 10, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/30097137/the-sleep-and-sex-survey-relationships-between-sexual-function-and-sleep
#10
Martin Seehuus, Wilfred Pigeon
OBJECTIVE: Distress and dysfunction in sleep and sex are both very common, and have been found to be separately related to anxiety, depression, and stress. Even so, and despite evidence linking obstructive sleep apnea and erectile disfunction, the connections between sleep and sex are largely understudied. METHOD: A large (N = 703) survey of people in the United States between 18 and 65 years old was conducted using Mechanical Turk, an on-line crowd-sourcing platform...
September 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/30096166/multiple-pde5is-use-as-a-marker-of-decreased-overall-men-s-health-a-real-life-study
#11
Davide Oreggia, Eugenio Ventimiglia, Paolo Capogrosso, Luca Boeri, Walter Cazzaniga, Filippo Pederzoli, Francesco Chierigo, Federico Dehò, Francesco Montorsi, Andrea Salonia
Erectile dysfunction (ED) is considered a sentinel marker for poor general men's health status. Severe ED has been associated with poor response to phosphodiesterase type 5 inhibitors (PDE5Is) therapy. We sought to assess the association of multiple PDE5Is prescription with the overall patients' health status. Socio-demographic and clinical variables from 939 consecutive white-European, heterosexual, sexually-active men seeking medical help for ED at same tertiary-referral academic outpatient clinic were analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/30089290/the-effect-of-hyperbaric-oxygen-therapy-on-erectile-functions-a-prospective-clinical-study
#12
Mehmet Oguz Sahin, Volkan Sen, Erhan Eser, Evin Koc, Umit Gumus, Cengiz Karakuzu, Oktay Ucer
INTRODUCTION: We aimed to evaluate the effects of hyperbaric oxygen therapy (HBOT) on erectile function in patients who had no cavernosal or urethral injury by using International Index of Erectile Function (IIEF) questionnaire. MATERIALS AND METHODS: The male patients who were treated by HBOT for several diseases between July 2017 and September 2017 were examined. All patients filled the IIEF questionnaire form before the first day and after the last day of HBOT and a questionnaire including demographic characteristics and medical history...
August 8, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/30089160/erectile-dysfunction-in-obstructive-sleep-apnea-patients-a-randomized-trial-on-the-effects-of-continuous-positive-airway-pressure-cpap
#13
Mercè Pascual, Jordi de Batlle, Ferran Barbé, Anabel L Castro-Grattoni, Josep M Auguet, Lydia Pascual, Manel Vilà, Anunciación Cortijo, Manuel Sánchez-de-la-Torre
OBJECTIVES: Obstructive sleep apnea (OSA) is among the least studied risk factors for erectile dysfunction (ED). We aimed to determine ED prevalence in newly-diagnosed OSA patients, describe their main characteristics and assess continuous positive airway pressure (CPAP) effects on ED. METHODS: Cross-sectional study assessing ED prevalence in OSA patients and open-label, parallel, prospective randomized controlled trial evaluating 3-month CPAP treatment effects on sexual function, satisfaction, and psychological, hormonal and biochemical profiles...
2018: PloS One
https://www.readbyqxmd.com/read/30086590/-pharmacological-treatment-of-bps
#14
Thilo Westhofen, Giuseppe Magistro, Christian Stief, Christian Gratzke
Pharmacological treatment of BPS is often considered the first therapeutic approach for patients who experience progression in lower urinary tract symptoms (LUTS).α1-adrenoceptor antagonists are often chosen as the first line pharmacological treatment, due to their rapid onset of action, as well as their significant impact on LUTS and Qmax and post-void residual. Adverse effects appear to be low.With larger prostate volume and LUTS, long term treatment with 5α-reductase inhibitors (5ARIs) significantly improves LUTS and post-void residual...
August 2018: Aktuelle Urologie
https://www.readbyqxmd.com/read/30083842/erectile-and-ejaculatory-functions-changes-following-bipolar-versus-monopolar-transurethral-resection-of-the-prostate-a-prospective-randomized-study
#15
Ahmed El-Assmy, Ahmed M ElShal, Ramy Mekkawy, Hamdy El-Kappany, El Housseiny I Ibrahiem
OBJECTIVES: To compare monopolar and bipolar transurethral resection of the prostate (M-TURP and B-TURP, respectively) focusing on erectile and ejaculatory functions in a randomized trial. METHODS: Between January 2013 and December 2014, all consecutive TURP candidates with benign prostatic hyperplasia (BPH) were prospectively randomized 1:1 into M-TURP/B-TURP arms and followed up at 2, and 4 weeks, 6 and 12 months after surgery. All patients were assessed using IIEF-15 (International index of erectile function-15) and Ej-MSHQ (ejaculatory domain-male sexual-health inventory)...
August 6, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30082069/rock-inhibitors-3-design-synthesis-and-structure-activity-relationships-of-7-azaindole-based-rho-kinase-rock-inhibitors
#16
Upul K Bandarage, Jingrong Cao, Jon H Come, John J Court, Huai Gao, Marc D Jacobs, Craig Marhefka, Suganthi Nanthakumar, Jeremy Green
Rho kinase (ROCK) inhibitors are potential therapeutic agents for the treatment of a variety of disorders including hypertension, glaucoma and erectile dysfunction. Here we disclose a series of potent and selective ROCK inhibitors based on a substituted 7-azaindole scaffold. Substitution of the 3-position of 7-azaindole led to compounds such as 37, which possess excellent ROCK inhibitory potency and high selectivity against the closely related kinase PKA.
August 15, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/30079903/assessment-of-knowledge-concerning-urology-among-medical-students-in-poland
#17
Oksana Skomarovska, Tomasz Stefura, Karolina Kainka, Łukasz Radziszewski, Anna Katarzyna Czech, Katarzyna Gronostaj, Tadeusz Hessel, Łukasz Curyło, Piotr L Chłosta
BACKGROUND AND OBJECTIVE: Urological diseases represent a significant health issue worldwide. Presented study aimed at assessing current urological knowledge and confidence in performing urological diagnostic and therapeutic procedures among medical students at Jagiellonian University Medical College in Poland and compare it on different stages of the undergraduate medical education. MATERIAL AND METHODS: We designed an anonymous survey distributed among Polish students from 1st to 6th year of medical studies, before and after clinical urology course...
2018: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/30079640/obesity-and-erectile-dysfunction-from-bench-to-clinical-implication
#18
REVIEW
Ki Hak Moon, So Young Park, Yong Woon Kim
Obesity is a major public health issue worldwide and is frequently associated with erectile dysfunction (ED). Both conditions may share an internal pathologic environment, also known as common soil. Their main pathophysiologic processes are oxidative stress, inflammation, and resultant insulin and leptin resistance. Moreover, the severity of ED is correlated with comorbid medical conditions, including obesity. Therefore, amelioration of these comorbidities may increase the efficacy of ED treatment with phosphodiesterase 5 inhibitors, the first-line medication for patients with ED...
July 25, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/30078733/practice-patterns-among-korean-urologists-for-glans-penis-augmentation-using-hyaluronic-acid-filler-in-the-management-of-premature-ejaculation
#19
Hyeong Guk Jeong, Sun Tae Ahn, Jong Wook Kim, Kyung Keun Seo, Dong Soo Lee, Hong Sun Uh, Je Jong Kim, Du Geon Moon
INTRODUCTION: Glans penis augmentation (GPA) using hyaluronic acid (HA) gel has been developed for treating premature ejaculation (PE) with penile hypersensitivity. The injected HA filler creates a barrier that reduces the tactile stimuli to the hypersensitive dorsal nerve. Although the HA filler is biodegradable and is believed to not cause permanent loss of sexual function, the current International Society for Sexual Medicine guideline for PE does not recommend this procedure owing to concerns regarding sexual dysfunction...
August 2, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/30078732/successful-use-of-an-inflatable-penile-prosthesis-for-the-treatment-of-distal-deficiency-of-the-tunica-albuginea-and-cavernous-tissue
#20
Nahid Punjani, Patrick McGarry, Gerald Brock
INTRODUCTION: Congenital hypoplasia of the distal half of the tunica albuginea has not been previously described. AIM: To review a patient presenting with erectile dysfunction secondary to congenital penile hypoplasia. METHODS: History, physical exam and penile Doppler ultrasound of the patient, followed by a discussed of treatment options and definitive management. RESULTS: Successful operative treatment of our patient with insertion of an inflatable penile prosthesis...
August 2, 2018: Sexual Medicine
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