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Sexual AND Disorder

Kitty Galiger-Dobos, Ferenc Túry
Common gynecological complications of various eating disorders include infertility, unwanted pregnancy, miscarriage, sexual dysfunction and complications in the treatment of gynecological cancers. Women with eating disorders typically see their gynecologists because of menstrual and other endocrine disorders or unexplained gastrointestinal symptoms, and often report on psychological symptoms (anxiety, depression or decreased libido). In spite of anovulation, menstruation may occur and ovulation without menstruation may be possible, which may lead to an increased incidence of unwanted pregnancies in case of prior or current eating disorders...
2018: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
Leah H Rubin, Siyi Li, Li Yao, Sarah K Keedy, James L Reilly, Scot K Hill, Jeffrey R Bishop, C Sue Carter, Hossein Pournajafi-Nazarloo, Lauren L Drogos, Elliot Gershon, Godfrey D Pearlson, Carol A Tamminga, Brett A Clementz, Matcheri S Keshavan, Su Lui, John A Sweeney
BACKGROUND: Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing. Abnormalities in these hormones are observed in schizophrenia and may contribute to multiple established sex differences associated with the disorder. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients. METHODS: OT and AVP serum concentrations were assayed in 35 individuals with schizophrenia (23 men) and 60 controls (24 men) from the Chicago BSNIP study site...
December 2018: Schizophrenia Research
Patrick Henry Lim, Guang Shi, Tengfei Wang, Sophia T Jenz, Megan K Mulligan, Eva E Redei, Hao Chen
Posttraumatic Stress Disorder (PTSD) is a complex illness, frequently co-morbid with depression, caused by both genetics, and the environment. Alcohol Use Disorder (AUD), which also co-occurs with depression, is often co-morbid with PTSD. To date, very few genes have been identified for PTSD and even less for PTSD comorbidity with AUD, likely because of the phenotypic heterogeneity seen in humans, combined with each gene playing a relatively small role in disease predisposition. In the current study, we investigated whether a genetic model of depression-like behavior, further developed from the depression model Wistar Kyoto (WKY) rat, is a suitable vehicle to uncover the genetics of co-morbidity between PTSD and AUD...
2018: Frontiers in Genetics
Karin de Punder, Sonja Entringer, Christine Heim, Christian E Deuter, Christian Otte, Katja Wingenfeld, Linn K Kuehl
Background: Major depressive disorder (MDD) is a complex psychiatric condition with different subtypes and etiologies. Exposure to adverse childhood experiences (ACE) is an important risk factor for the development of MDD later in life. Evidence suggests that pro-inflammatory processes may convey this risk as both MDD and ACE have been related to increased levels of inflammation. In the present study, we aimed to disentangle the effects of MDD and ACE on inflammation levels. Methods: Markers of inflammation (plasma interleukin(IL)-6 and high sensitive C-reactive protein (hsCRP) concentrations, white blood cell (WBC) count and a composite inflammation score (CIS) combining all three) were assessed in 23 MDD patients with ACE, 23 MDD patients without ACE, 21 healthy participants with ACE, and 21 healthy participants without ACE (mean age: 35 ± 11 (SD) years)...
2018: Frontiers in Psychiatry
Ana Carolina Tahira, André Rocha Barbosa, Arthur Sant'Anna Feltrin, Vinicius Daguano Gastaldi, Victor Hugo Calegari de Toledo, José Geraldo de Carvalho Pereira, Bianca Cristina Garcia Lisboa, Viviane Neri de Souza Reis, Ana Cecília Feio Dos Santos, Mariana Maschietto, Helena Brentani
The male-biased prevalence of certain neurodevelopmental disorders and the sex-biased outcomes associated with stress exposure during gestation have been previously described. Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across therian mammals, SOX3 and SRY, could induce sexual adaptive changes that result in a differential risk for neurodevelopmental disorders. ChIP-seq/chip data showed that SOX3/SRY gene targets were expressed in different brain cell types in mice...
December 9, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Aethele Khunda, Carol McCormick, Paul Ballard
INTRODUCTION AND HYPOTHESIS: Sexual function is being increasingly recognized as an important patient-reported outcome. Sacral neuromodulation (SNM) is a treatment with an expanding list of indications. The effect of sacral neuromodulation on sexual function has been examined in a number of studies with variable results. In this review, we aim to systematically review the literature and pool the data if appropriate. METHODS: The literature search was conducted primarily on the Healthcare Databases Advanced Search (HDAS) platform using the Medline, EMBASE and CINHAL search engines...
December 7, 2018: International Urogynecology Journal
Ozan Dogan, Murat Yassa
Background: Influencing factors to decide for labiaplasty are evolving and show diversity among different settings and countries. Updated underlying motivators may assist in the clinical decision-making and assessing outcomes from the patients' perspective. Objective: Herein, the main motivators of women undergoing labiaplasty and sociodemographic features are discussed. Methods: Seventy-one patients who were scheduled for labiaplasty were assessed with an open-ended, well-detailed questionnaire to determine the main motivational factors from the patients' perspective...
December 8, 2018: Aesthetic Surgery Journal
André de Macêdo Medeiros, Regina Helena Silva
Alzheimer's disease (AD) is a neurodegenerative disorder that drastically compromises patients' and relatives' quality of life, besides being a significant economic burden to global public health. Its pathophysiology is not completely elucidated yet, hence, the current therapies are restricted to treating the symptoms. Over the years, several epidemiological studies have shown disproportionalities in AD when sex is considered, which has encouraged researchers to investigate the potentiality of sex as a risk factor...
December 1, 2018: Journal of Alzheimer's Disease: JAD
Maciej Juryńczyk, Anu Jacob, Kazuo Fujihara, Jacqueline Palace
The field of central nervous system (CNS) inflammatory diseases has recently broadened to include a new condition associated with pathogenic serum antibodies against myelin oligodendrocyte glycoprotein (MOG). This is distinct from multiple sclerosis (MS) and aquaporin-4 (AQP4) antibody neuromyelitis optica spectrum disorders (NMOSD). MOG antibody-associated disease phenotypes are varied and range from classical neuromyelitis optica to acute demyelinating encephalomyelitis and cortical encephalitis. The diagnosis depends on using a reliable, specific and sensitive assay of the antibody...
December 8, 2018: Practical Neurology
S Paige Hertweck, David H Rothstein
The transition from adolescence to young adulthood in patients with reproductive health care needs such as disorders of sexual development (DSDs) and congenital anomalies is a complex process occurring over several years. The transition process for these patients has is still poorly understood. The patients with DSDs and reproductive issues have specific and unique issues regarding timing of disclosure of diagnosis, genital examinations, gonadectomy, vaginal treatments, surgical procedures hormone replacement therapy, use of long term medication and potential cancer screening...
December 5, 2018: Journal of Pediatric and Adolescent Gynecology
Johanna A M du Mortier, Henny A D Visser, Anton J L M van Balkom, Harold J G M van Megen, Adriaan W Hoogendoorn, Gerrit Glas, Patricia van Oppen
Obsessive-compulsive symptom dimensions are important in studies about the pathogenesis and treatment of obsessive-compulsive disorder. More than 30 factor analytic studies using the Yale-Brown Obsessive Compulsive Scale Symptom Checklist (Y-BOCS-SC) interview version have been published. However, a drawback of the Y-BOCS-SC interview is that it is time-consuming for the clinician. Baer's self-report version of the Y-BOCS-SC could be a less time-consuming alternative. The purpose of this study was to examine the factor structure of Baer's self-report Y-BOCS-SC...
November 19, 2018: Psychiatry Research
Kylie-Ann Mallitt, David P Wilson, James Jansson, Ann McDonald, Handan Wand, Jeffrey J Post
BACKGROUND: Treatment as prevention approaches for HIV require optimal HIV testing strategies to reduce undiagnosed HIV infections. In most settings, HIV testing strategies still result in unacceptably high rates of missed and late diagnoses. This study aimed to identify clinical opportunities for targeted HIV testing in persons at risk to facilitate earlier HIV diagnosis in New South Wales, Australia; and to assess the duration between the diagnosis of specific conditions and HIV diagnosis...
2018: PloS One
Nick Wilson, Anne Tucker, Deborah Heath, Peter Scarborough
OBJECTIVES: To describe the patterns of alcohol use in James Bond movies over six decades. DESIGN: Film content analysis. SETTING: Wide range of international locations in 24 James Bond movies (Eon Productions series, 1962-2015). MAIN OUTCOME MEASURES: Drinking episodes for Bond and major female characters; alcohol product placement in films; peak estimated blood alcohol concentrations; features relevant to DSM-5 criteria for alcohol use disorder...
December 10, 2018: Medical Journal of Australia
George A Stamatiades, Rona S Carroll, Ursula B Kaiser
The hypothalamic decapeptide, GnRH, is the gatekeeper of mammalian reproductive development and function. Activation of specific, high affinity cell surface receptors (GnRHR) on gonadotropes by GnRH triggers signal transduction cascades to stimulate the coordinated synthesis and secretion of the pituitary gonadotropins, FSH and LH. These hormones direct gonadal steroidogenesis and gametogenesis, making their tightly regulated production and secretion essential for normal sexual maturation and reproductive health...
December 4, 2018: Endocrinology
Ariane Gomes Dos Santos, Claudete Ferreira de Souza Monteiro
OBJECTIVE: to verify associations between the types of intimate partner violence and the domains of common mental disorders in women. METHOD: cross-sectional study with 369 women. The information was obtained through the instruments Self-Reporting Questionnaire and Conflict Tactic Scales. To analyze the data, Pearson's Chi-Square test, Fisher's exact test and Odds Ratio were used. RESULTS: women who reported physical abuse with and without sequela were respectively 2...
November 29, 2018: Revista Latino-americana de Enfermagem
Renata Prado Vasconcelos, Milena Simões Peixoto, Keciany Alves de Oliveira, Andrea C F Ferreira, Andrelina Souza, Denise P Carvalho, Ariclecio Cunha de Oliveira, Rodrigo Soares Fortunato
The development of obesity related-metabolic disorders is more evident in male in comparison to female subjects, but the mechanisms are unknown. Several studies have shown that oxidative stress is involved in the pathophysiology of obesity, but the majority of them were performed in male animals. The aim of this study was to evaluate the sex-related differences in the subcutaneous adipose tissue redox homeostasis and inflammation of rats chronically fed a high fat diet. NADPH oxidase (NOX), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase activities were evaluated in the subcutaneous adipose tissue (SC) of adult male and female rats fed either a standard chow (SCD) or a high-fat diet (HFD) for 11 weeks...
December 5, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Mojdeh Banaei, Azam Moridi, Sareh Dashti
Introduction: Considering physical and emotional changes affecting women's sexual function in postpartum period. Aim: This study was conducted to determine the sexual dysfunction and postpartum-related factors in Bandar Abbas women in 2016. Material and Methods: This analytical cross-sectional study used systematic random sampling on 432 postpartum women referred to Bandar Abbas Healthcare Centers. Data were collected by Demographic and Obstetrics Questionnaire and Female Sexual Function Index (FSFI) Questionnaire through interview and were analyzed by using SPSS ver...
October 2018: Materia Socio-medica
Sheng-Chiang Wang, Chen-Cheng Lin, Chun-Chuan Chen, Nian-Sheng Tzeng, Yia-Ping Liu
Posttraumatic stress disorder (PTSD) is a trauma-induced mental disorder characterized by fear extinction abnormalities, which involve biological dysfunctions among fear circuit areas in the brain. Oxytocin (OXT) is a neuropeptide that regulates sexual reproduction and social interaction and has recently earned specific attention due to its role in adjusting neurobiological and behavioral correlates of PTSD; however, the mechanism by which this is achieved remains unclear. The present study aimed to examine whether the effects of OXT on traumatic stress-induced abnormalities of fear extinction (specifically induced by single prolonged stress (SPS), an animal model of PTSD) are associated with pro-inflammatory cytokines...
December 3, 2018: International Journal of Molecular Sciences
Kelly A Curran
BACKGROUND: After several visits with unrelated complaints, a 16-year-old female disclosed symptoms of unwanted genital arousal and was diagnosed with persistent genital arousal disorder (PGAD). CASE: A 16-year-old female with history of depression, sexual abuse, and dysmenorrhea insistently requested etonogestrel rod removal. At two visits following implant removal, the patient disclosed the reason for her insistence: PGAD symptoms developed after implant insertion, though they worsened with removal...
December 1, 2018: Journal of Pediatric and Adolescent Gynecology
Abulizi Keremu, Aziguli Yaoliwasi, Mayire Tuerhong, Nafeisha Kadeer, Heyi, Adilijiang Yiming, Xiamixinuer Yilike
The purposes of this study were to establish and to explore the biological basis of the chronic stress induced premature ovarian failure (POF) model, also to explore the therapeutic effects of the traditional Chinese medicine Munziq. Sexually matured female SD rats were fed with spinach and cilantro in cold and wet conditions for about 20 weeks, until a chronic stress (CS) model was established. CS rats were divided into POF stress model group and stress model group according to weekly biological characteristics and hormone level detection (LH, FSF and E2)...
December 4, 2018: Molecular Reproduction and Development
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